Detailed information for compound 402460

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1172.3 | Formula: C57H61N3O18S3
  • H donors: 7 H acceptors: 14 LogP: 6.38 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 4
  • SMILES: Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)N(S(=O)(=O)C)S(=O)(=O)C.OCC(=O)[C@]1(O)C[C@@H](OC2CC(N)C(C(O2)C)O)c2c(C1)c(O)c1c(c2O)C(=O)c2c(C1=O)cccc2OC
  • InChi: 1S/C30H32N2O7S3.C27H29NO11/c1-41(35,36)32(42(2,37)38)23-10-6-22(7-11-23)30-28(26-15-12-24(33)20-27(26)40-30)29(34)21-8-13-25(14-9-21)39-19-18-31-16-4-3-5-17-31;1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h6-15,20,33H,3-5,16-19H2,1-2H3;3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t;10?,13?,15-,17?,22?,27-/m.0/s1
  • InChiKey: LBVXLYKKAVPSBB-BFLMDSDJSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0058 0.033 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.0175 0.1198 0.2094
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0557 0.4031 0.7192
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0884 0.1529
Brugia malayi Cytochrome P450 family protein 0.0019 0.0036 0.0062
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0282 0.1991 0.3547
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.1602 0.2084
Echinococcus granulosus tumor protein p63 0.0329 0.2334 0.2334
Leishmania major hypothetical protein, conserved 0.052 0.3758 1
Entamoeba histolytica hypothetical protein 0.0035 0.0156 0.0218
Echinococcus granulosus geminin 0.0166 0.1132 0.1131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.1554 0.2733
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0145 0.0974 0.169
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0034 0.0039
Loa Loa (eye worm) hypothetical protein 0.0067 0.0396 0.0515
Toxoplasma gondii ck2 beta subunit 0.0036 0.016 0.0916
Brugia malayi serine/threonine-protein kinase plk-2 0.0186 0.1279 0.2286
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0058 0.033 0.0378
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0031 0.0127 0.0146
Entamoeba histolytica hypothetical protein 0.063 0.4574 0.8169
Echinococcus granulosus single minded 2 0.0035 0.0156 0.0155
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Brugia malayi Protein kinase domain containing protein 0.013 0.0861 0.1538
Trypanosoma brucei polo-like protein kinase 0.0186 0.1279 0.633
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0052 0.0051
Onchocerca volvulus 0.0058 0.033 0.1117
Echinococcus multilocularis high voltage activated calcium channel beta 0.0084 0.0522 0.0521
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0044
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0059 0.0336 0.0336
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0058 0.033 0.0378
Loa Loa (eye worm) hypothetical protein 0.0091 0.0573 0.0745
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0282 0.1991 0.3521
Brugia malayi Peptidase family M13 containing protein 0.0091 0.0573 0.1023
Onchocerca volvulus 0.0035 0.0156 0.0298
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.068 0.0885
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0282 0.1991 0.3559
Trichomonas vaginalis PIKK family atypical protein kinase 0.023 0.1604 0.2824
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0022 0.0061 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0207 0.1432 0.2515
Giardia lamblia Kinase, CMGC CK2 0.0133 0.0884 0.2672
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Loa Loa (eye worm) hypothetical protein 0.0091 0.0573 0.0745
Echinococcus multilocularis endothelin converting enzyme 1 0.0091 0.0573 0.0573
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0145 0.0974 0.5559
Leishmania major phosphatidylinositol kinase, putative 0.0058 0.033 0.0849
Loa Loa (eye worm) hypothetical protein 0.0078 0.0473 0.0615
Echinococcus multilocularis 0.0058 0.033 0.0329
Echinococcus granulosus lamin 0.0026 0.0093 0.0092
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1186 0.87 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0257 0.1801 0.318
Echinococcus granulosus lamin dm0 0.0026 0.0093 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.2 0.3537
Trichomonas vaginalis PIKK family atypical protein kinase 0.0257 0.1801 0.318
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0058 0.033 0.3378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0801 0.138
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0114 0.0113
Loa Loa (eye worm) phosphatidylinositol 3 0.0283 0.2 0.2603
Brugia malayi 6-phosphofructokinase 0.0106 0.068 0.1215
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0025
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.068 0.1162
Schistosoma mansoni kinase 0.0096 0.0609 0.0699
Entamoeba histolytica protein kinase domain containing protein 0.0133 0.0884 0.1529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.1355 0.2376
Schistosoma mansoni hypothetical protein 0.0158 0.107 0.1229
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0031 0.0127 0.0127
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0058 0.033 0.0587
Loa Loa (eye worm) peptidase family M13 containing protein 0.0067 0.0396 0.0515
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0282 0.1991 0.3521
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0034 0.0039
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0355 0.2534 0.4498
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0058 0.033 0.1882
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0245 0.1718 0.1717
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0058 0.033 0.0587
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.1279 0.224
Schistosoma mansoni voltage-gated cation channel 0.0031 0.0127 0.0146
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0108 0.0799
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0114 0.0113
Echinococcus multilocularis tumor protein p63 0.0329 0.2334 0.2334
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0145 0.0974 0.169
Echinococcus granulosus cyclin dependent kinase 19 0.013 0.0861 0.0861
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0207 0.1432 0.3792
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0122 0.0801 0.1415
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.025 0.1751 0.3089
Loa Loa (eye worm) phosphatidylinositol 3 0.0224 0.1558 0.2027
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0336 0.0543
Leishmania major phosphatidylinositol kinase related protein, putative 0.0073 0.0435 0.1131
Brugia malayi 6-phosphofructokinase 0.0106 0.068 0.1215
Plasmodium vivax unspecified product 0.0133 0.0884 0.9082
Brugia malayi SH2 domain containing protein 0.0659 0.4787 0.856
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0145 0.0974 0.1724
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0197 0.0226
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.005 0.0264 0.0673
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.068 0.1785
Entamoeba histolytica hypothetical protein 0.0136 0.0907 0.157
Brugia malayi Protein kinase domain containing protein 0.0017 0.0024 0.0041
Schistosoma mansoni lamin 0.0026 0.0093 0.0106
Loa Loa (eye worm) phosphofructokinase 0.0106 0.068 0.0885
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.068 0.068
Schistosoma mansoni hypothetical protein 0.0035 0.0156 0.0178
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0034 0.0059
Onchocerca volvulus 0.005 0.0264 0.0807
Loa Loa (eye worm) hypothetical protein 0.0462 0.3327 0.433
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0044
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.068 0.1162
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0046 0.0238 0.0272
Onchocerca volvulus 0.0045 0.0232 0.0654
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.004 0.0196 0.0291
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0156 0.0178
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0767 0.5592 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0058 0.033 0.057
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0133 0.0884 0.9082
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Loa Loa (eye worm) hypothetical protein 0.0069 0.0408 0.0531
Entamoeba histolytica hypothetical protein 0.0035 0.0156 0.0218
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0046 0.024 0.0312
Schistosoma mansoni hypothetical protein 0.0058 0.033 0.0378
Loa Loa (eye worm) hypothetical protein 0.0067 0.0396 0.0515
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.068 1
Giardia lamblia Hypothetical protein 0.0058 0.033 0.0763
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0059 0.0336 0.153
Trichomonas vaginalis set domain proteins, putative 0.0233 0.1623 0.2859
Loa Loa (eye worm) hypothetical protein 0.0275 0.1936 0.252
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0036 0.0007
Loa Loa (eye worm) hypothetical protein 0.0031 0.0127 0.0165
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0019 0.0021
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0312 0.2214 0.2881
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.1279 0.147
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0034 0.0034
Plasmodium vivax SET domain protein, putative 0.0029 0.0114 0.1157
Echinococcus multilocularis expressed protein 0.0363 0.259 0.2589
Schistosoma mansoni serine/threonine protein kinase 0.0312 0.2214 0.2544
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Loa Loa (eye worm) hypothetical protein 0.0027 0.0094 0.0121
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Loa Loa (eye worm) hypothetical protein 0.0058 0.033 0.0428
Brugia malayi peptidase family M13 containing protein 0.0022 0.0061 0.0107
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.016 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0282 0.0446
Onchocerca volvulus 0.0233 0.1624 0.722
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0283 0.2 0.2298
Schistosoma mansoni hypothetical protein 0.0024 0.0073 0.0083
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0767 0.5592 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0186 0.1279 0.1279
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0186 0.1279 0.1664
Echinococcus multilocularis protein kinase shaggy 0.005 0.0264 0.0263
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.0036 0.0007
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0312 0.2214 0.2214
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.068 0.1162
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0767 0.5592 1
Onchocerca volvulus 0.0041 0.0197 0.0491
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0091 0.0573 0.8335
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.0983 0.1278
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0058 0.033 0.057
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0108 0.0132
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0058 0.033 0.0329
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0427 0.0427
Toxoplasma gondii hypothetical protein 0.0019 0.0036 0.0207
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0156 0.0276
Entamoeba histolytica hypothetical protein 0.0058 0.033 0.0531
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0133 0.0883 0.5043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0368 0.06
Schistosoma mansoni casein kinase II beta subunit 0.0036 0.016 0.0184
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0046
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.005 0.0264 0.0263
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0108 0.0616
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.033 0.0428
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0088 0.0551 0.0633
Loa Loa (eye worm) hypothetical protein 0.0133 0.0883 0.1149
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0034 0.0034
Echinococcus multilocularis serine protein kinase ATM 0.0136 0.0907 0.0906
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0059 0.0336 0.0543
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0034 0.0039
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0108 0.0132
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0283 0.2 0.3563
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0091 0.0573 0.1023
Giardia lamblia Kinase, PLK 0.0186 0.1279 0.4031
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0108 0.1097
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0145 0.0974 0.0973
Plasmodium vivax glycogen synthase kinase 3, putative 0.005 0.0264 0.2701
Loa Loa (eye worm) phosphatidylinositol 3 0.1049 0.7683 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0186 0.1279 0.2272
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0539 0.3896 0.6967
Plasmodium vivax hypothetical protein 0.0058 0.033 0.3378
Entamoeba histolytica hypothetical protein 0.0035 0.0156 0.0218
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.068 0.1198
Brugia malayi Pre-SET motif family protein 0.0204 0.1414 0.2526
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0034 0.0039
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.016 0.0266
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.004 0.0196 0.0291
Onchocerca volvulus 0.0058 0.033 0.1117
Echinococcus granulosus bloom syndrome protein 0.0021 0.0052 0.0051
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0034 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0059 0.0067
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0058 0.033 0.1882
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0058 0.033 0.3378
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.068 0.1162
Echinococcus granulosus casein kinase ii subunit beta 0.0036 0.016 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.1355 0.2376
Onchocerca volvulus 0.0048 0.0253 0.0755
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0767 0.5592 1
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.068 0.1162
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0168 0.1142 0.1141
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0884 0.1529
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0114 0.013
Loa Loa (eye worm) hypothetical protein 0.0075 0.045 0.0584
Schistosoma mansoni endothelin-converting enzyme-related 0.0022 0.0061 0.0069
Schistosoma mansoni single-minded 0.0047 0.0247 0.0283
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0059 0.0076
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.016 0.1637
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0058 0.033 0.0329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0175 0.1198 0.2094
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0034 0.0039
Leishmania major casein kinase II, putative 0.0133 0.0884 0.2329
Schistosoma mansoni hypothetical protein 0.0024 0.0073 0.0083
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.068 0.1162
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0122 0.0801 0.1431
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0058 0.033 0.0329
Schistosoma mansoni hypothetical protein 0.0094 0.0596 0.0684
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0108 0.0132
Schistosoma mansoni hypothetical protein 0.0166 0.1132 0.13
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0034 0.0034
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0034 0.0039
Echinococcus granulosus expressed protein 0.0363 0.259 0.2589
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0034 0.0059
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0059 0.0067
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Trypanosoma brucei protein kinase, putative 0.005 0.0264 0.1161
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0336 0.0543
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0108 0.0132
Loa Loa (eye worm) hypothetical protein 0.0659 0.4787 0.623
Plasmodium falciparum GAF domain-related protein, putative 0.0019 0.0036 0.0038
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0207 0.1432 0.7109
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0075 0.045 0.0449
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0058 0.033 0.3156
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0034 0.0039
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.005 0.0264 0.0303
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0031 0.0127 0.0127
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0034 0.0059
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0112 0.0726 0.3514
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.045 0.0747
Echinococcus granulosus casein kinase ii subunit alpha 0.0133 0.0884 0.0884
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1361 1 1
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.068 0.068
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0884 0.1529
Entamoeba histolytica protein kinase domain containing protein 0.005 0.0264 0.0413
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0031 0.0127 0.0225
Schistosoma mansoni hypothetical protein 0.0075 0.045 0.0516
Echinococcus multilocularis lamin 0.0026 0.0093 0.0092
Schistosoma mansoni lamin 0.0026 0.0093 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0209 0.1447 0.2541
Brugia malayi Cytochrome P450 family protein 0.0029 0.011 0.0195
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0145 0.0974 0.1724
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0557 0.4031 0.7192
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0145 0.0974 0.2568
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0245 0.1718 0.307
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0045 0.0057
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0058 0.033 0.0378
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0034 0.0034
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0059 0.0336 0.0543
Mycobacterium tuberculosis Conserved hypothetical protein 0.0058 0.033 0.4554
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0108 0.0616
Toxoplasma gondii FATC domain-containing protein 0.0136 0.0907 0.5179
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0046 0.0238 0.0272
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.016 0.1637
Entamoeba histolytica hypothetical protein 0.0035 0.0156 0.0218
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0336 0.0543
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0108 0.0132
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0108 0.5
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0059 0.0336 0.0543
Echinococcus multilocularis cyclin dependent kinase 19 0.013 0.0861 0.0861
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0058 0.033 0.0531
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0044
Loa Loa (eye worm) hypothetical protein 0.0045 0.0232 0.0301
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0136 0.0907 0.162
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0145 0.0974 0.0973
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0034 0.0039
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0036 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0767 0.5592 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0058 0.033 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.1553 0.2732
Entamoeba histolytica protein kinase, putative 0.005 0.0264 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.1553 0.2732
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0034 0.0034
Schistosoma mansoni fkbp-rapamycin associated protein 0.0122 0.0801 0.092
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0059 0.0336 0.0543
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0136 0.0907 0.4435
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0031 0.0127 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0527 0.0887
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0036 0.016 0.0916
Brugia malayi Pre-SET motif family protein 0.0029 0.0114 0.0201
Echinococcus multilocularis voltage dependent calcium channel 0.0031 0.0127 0.0127
Echinococcus multilocularis survival motor neuron protein 1 0.0462 0.3327 0.3326
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.016 0.0227
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0091 0.0573 0.0658
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0088 0.0551 0.0551
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0059 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0861 0.0989
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0059 0.0336 0.0582
Schistosoma mansoni neprilysin-2 (M13 family) 0.0046 0.0238 0.0272
Loa Loa (eye worm) RecQ helicase 0.0021 0.0052 0.0066
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0061 0.0069
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.068 1
Brugia malayi hypothetical protein 0.0159 0.1074 0.1918
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0059 0.0058
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.016 0.0227
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0093 0.012
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0058 0.033 0.0531
Loa Loa (eye worm) gastrulation defective protein 1 0.0127 0.0837 0.1089
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0036 0.0043
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0282 0.1991 0.9955
Plasmodium vivax hypothetical protein, conserved 0.0058 0.033 0.3378
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0034 0.0039
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0312 0.2214 0.2214
Toxoplasma gondii CMGC kinase, CK2 family 0.0133 0.0884 0.5049
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0145 0.0974 1
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0312 0.2214 0.3958
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0075 0.045 0.0449
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0026 0.009 0.0159
Loa Loa (eye worm) peptidase family M13 containing protein 0.0067 0.0396 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.025 0.1751 0.3089
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0283 0.2 0.5308
Echinococcus granulosus survival motor neuron protein 1 0.0462 0.3327 0.3326
Schistosoma mansoni hypothetical protein 0.0024 0.0073 0.0083
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0224 0.1558 0.277
Brugia malayi intracellular kinase 0.005 0.0264 0.047
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0247 0.0283
Entamoeba histolytica hypothetical protein 0.0058 0.033 0.0531
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0034 0.0034
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0108 0.1097
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0059 0.0336 0.153
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0059 0.0336 0.0386
Trichomonas vaginalis PIKK family atypical protein kinase 0.025 0.1751 0.3089
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0058 0.033 0.1882
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0052 0.0031
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0427 0.0427
Loa Loa (eye worm) zinc metallopeptidase 4 0.0022 0.0061 0.0079
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.005 0.0264 0.1507
Toxoplasma gondii GAF domain-containing protein 0.0019 0.0036 0.0207
Toxoplasma gondii hypothetical protein 0.0052 0.0282 0.1611
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0114 0.0113
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.5748 0.5747
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0034 0.0034
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0283 0.2 1
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.1279 0.224
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0034 0.0039
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0058 0.033 0.3156
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0044
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0145 0.0974 0.4774
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0168 0.1142 0.1141
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0059 0.0336 0.0543
Echinococcus granulosus protein kinase shaggy 0.005 0.0264 0.0263
Brugia malayi PXA domain containing protein 0.002 0.0045 0.0077
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0186 0.1279 0.1279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.033 0.0531
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0036 0.0043
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.005 0.0264 0.0452
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0238 0.0272
Plasmodium falciparum casein kinase II beta chain 0.0036 0.016 0.1357
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0036 0.0046
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0245 0.1718 0.1974
Schistosoma mansoni protein kinase 0.0133 0.0884 0.1016
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0088 0.0551 0.0633
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0088 0.0551 0.0551
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0283 0.2 0.3537
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0058 0.033 0.0329
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0114 0.013
Echinococcus granulosus intermediate filament protein 0.0026 0.0093 0.0092
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0329 0.2336 0.2684
Leishmania major hypothetical protein, unknown function 0.0058 0.033 0.0849
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0044
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0059 0.0336 0.0543
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0034 0.0044
Echinococcus multilocularis voltage dependent calcium channel 0.0031 0.0127 0.0127
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0034 0.0034
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0245 0.1718 0.1717
Brugia malayi hypothetical protein 0.0019 0.0034 0.0059
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0058 0.033 0.0531
Giardia lamblia Casein kinase II beta chain 0.0036 0.016 0.018
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0122 0.0801 0.0801
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0034 0.0034
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Leishmania major phosphatidylinositol 3-kinase, putative 0.0145 0.0974 0.2568
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0034 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0368 0.06
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0026 0.009 0.0101
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0283 0.2 0.3563
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0026 0.009 0.009
Brugia malayi phosphofructokinase 0.0106 0.068 0.1215
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0257 0.1802 0.8993
Brugia malayi intermediate filament protein 0.0026 0.0093 0.0163
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0099 0.0635 0.0825
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0245 0.1718 0.3057
Schistosoma mansoni hypothetical protein 0.0166 0.1132 0.13
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.033 0.0428
Echinococcus granulosus high voltage activated calcium channel beta 0.0084 0.0522 0.0521
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.1554 0.2733
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0034 0.0034
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0031 0.0127 0.0127
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0312 0.2214 0.2881
Trypanosoma cruzi casein kinase II, putative 0.0133 0.0884 0.1564
Trichomonas vaginalis PIKK family atypical protein kinase 0.023 0.1604 0.2824
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0326 0.2319 0.4111
Trypanosoma cruzi hypothetical protein, conserved 0.0462 0.3324 0.5936
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Toxoplasma gondii hypothetical protein 0.0019 0.0036 0.0207
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0196 0.1347 0.4265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.1553 0.2732
Loa Loa (eye worm) hypothetical protein 0.01 0.0635 0.0826
Loa Loa (eye worm) CMGC/GSK protein kinase 0.005 0.0264 0.0343
Brugia malayi Casein kinase II, alpha chain 0.0133 0.0884 0.1579
Entamoeba histolytica protein kinase rad3, putative 0.0122 0.0801 0.138
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0132 0.0879 0.1519
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.063 0.4574 0.8169
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0034 0.0034
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0336 0.0543
Schistosoma mansoni hypothetical protein 0.0051 0.0273 0.0313
Echinococcus multilocularis musashi 0.0026 0.0093 0.0092
Loa Loa (eye worm) CMGC/GSK protein kinase 0.005 0.0264 0.0343
Trichomonas vaginalis PIKK family atypical protein kinase 0.025 0.1751 0.3089
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.033 0.0428
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0884 0.1529
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0059 0.0336 0.0336
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0145 0.0974 0.0973
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.1355 0.2376
Echinococcus multilocularis geminin 0.0166 0.1132 0.1131
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0059 0.0336 0.0582
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1414 0.1839
Mycobacterium ulcerans zinc metalloprotease 0.0091 0.0573 0.8336
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0052 0.009
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0767 0.5592 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0396 0.0515
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0026 0.009 0.0103
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0114 0.0649
Schistosoma mansoni neprilysin 0.0024 0.0073 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0132 0.0879 0.1519
Brugia malayi Angiotensin-converting enzyme family protein 0.0599 0.4342 0.7764
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0145 0.0974 0.5559
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.016 0.0319
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Entamoeba histolytica protein kinase domain containing protein 0.005 0.0264 0.0413
Brugia malayi Cytochrome P450 family protein 0.0019 0.0036 0.0062
Loa Loa (eye worm) hypothetical protein 0.0069 0.0408 0.0531
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0709 0.5158 0.922
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0145 0.0974 0.1118
Loa Loa (eye worm) calcium channel 0.0031 0.0127 0.0165
Trypanosoma cruzi polo-like protein kinase, putative 0.0186 0.1279 0.2272
Loa Loa (eye worm) hypothetical protein 0.0069 0.0408 0.0531
Trichomonas vaginalis PIKK family atypical protein kinase 0.025 0.1751 0.3089
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0093 0.0163
Echinococcus granulosus expressed conserved protein 0.0158 0.107 0.1069
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Mycobacterium leprae conserved hypothetical protein 0.0058 0.033 0.4554
Brugia malayi FAT domain containing protein 0.0075 0.045 0.0802
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0078 0.0473 0.0827
Echinococcus multilocularis casein kinase ii subunit beta 0.0036 0.016 0.016
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0122 0.0801 0.0801
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0145 0.0974 0.169
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0264 0.0413
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0059 0.0336 0.0582
Giardia lamblia Phosphatidylinositol 4-kinase 0.0058 0.033 0.0763
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0084 0.0522 0.0599
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.068 0.0781
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0058 0.033 0.0329
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.012
Echinococcus granulosus endothelin converting enzyme 1 0.0091 0.0573 0.0573
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1186 0.87 0.87
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0174 0.1186 0.2119
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0591 0.1001
Brugia malayi PXA domain containing protein 0.002 0.0045 0.0077
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0052 0.0031
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0145 0.0974 0.1118
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0283 0.2 0.5308
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0156 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.1248 0.2184
Schistosoma mansoni intermediate filament proteins 0.0026 0.0093 0.0106
Brugia malayi follicle stimulating hormone receptor 0.023 0.1602 0.2863
Mycobacterium leprae probable zinc metalloprotease 0.0091 0.0573 0.8335
Echinococcus multilocularis Zinc finger, PHD finger 0.0145 0.0974 0.0973
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.2 0.3537
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0253 0.029
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0136 0.0907 0.1042
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0257 0.1802 0.478
Echinococcus granulosus serine protein kinase ATM 0.0136 0.0907 0.0906
Loa Loa (eye worm) hypothetical protein 0.0026 0.0089 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0175 0.1198 0.2094
Toxoplasma gondii peptidase family M13 protein 0.0091 0.0573 0.3273
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0034 0.0034
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.016 0.0319
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0061 0.0069
Loa Loa (eye worm) hypothetical protein 0.0029 0.0114 0.0147
Loa Loa (eye worm) phosphatidylinositol kinase 0.0058 0.033 0.0428
Plasmodium falciparum glycogen synthase kinase 3 0.005 0.0264 0.2457
Loa Loa (eye worm) Csnk2b protein 0.0036 0.016 0.0208
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0884 0.1529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.1554 0.2733
Brugia malayi M-phase phosphoprotein, mpp8 0.0099 0.0635 0.1133
Trypanosoma cruzi target of rapamycin kinase 3 0.0257 0.1802 0.3209
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0136 0.0907 0.1604
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0312 0.2214 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.016 0.1082 0.5325
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0108 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0257 0.1801 0.318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0336 0.0543
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.1279 0.224
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.1279 0.224
Echinococcus multilocularis expressed conserved protein 0.0158 0.107 0.1069
Brugia malayi Protein kinase domain containing protein 0.0312 0.2214 0.3958
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.068 0.0885
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0034 0.0034
Onchocerca volvulus 0.0094 0.0596 0.2372
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0059 0.0103
Giardia lamblia Kinase, CMGC GSK 0.005 0.0264 0.0537
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1186 0.87 0.87
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Schistosoma mansoni hypothetical protein 0.0024 0.0073 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0282 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.033 0.0531
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0036 0.0046
Brugia malayi Csnk2b protein 0.0036 0.016 0.0284
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0283 0.2 0.2
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.068 1
Schistosoma mansoni survival motor neuron protein 0.0094 0.0596 0.0684
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0026 0.009 0.009
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0145 0.0974 0.1266
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0419 0.3004 0.5372
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0283 0.2 0.2
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0156 0.0155
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0591 0.1001
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0156 0.0155
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0031 0.0127 0.0127
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0186 0.1279 0.3384
Leishmania major phosphatidylinositol 3-kinase, putative 0.0197 0.1355 0.3586
Giardia lamblia GTOR 0.0283 0.2 0.6512
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0061 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.2 0.3537
Plasmodium falciparum casein kinase II beta chain 0.0036 0.016 0.1357
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0283 0.2 0.3575
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0026 0.009 0.0159
Brugia malayi hypothetical protein 0.0035 0.0156 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0036 0.0004
Echinococcus multilocularis lamin dm0 0.0026 0.0093 0.0092
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0537 0.3879 0.3879
Echinococcus multilocularis casein kinase ii subunit alpha 0.0133 0.0884 0.0884
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0031 0.0127 0.0127
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0283 0.2 1
Schistosoma mansoni hypothetical protein 0.0024 0.0073 0.0083
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0193 0.133 0.2331
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0034 0.0039
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0238 0.0272
Entamoeba histolytica hypothetical protein 0.0058 0.033 0.0531
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0036 0.0046
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.1279 0.224
Onchocerca volvulus 0.0099 0.0635 0.2554
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0282 0.0446
Entamoeba histolytica serine/threonine protein kinase, putative 0.0186 0.1279 0.224
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0336 0.0543
Leishmania major cytochrome p450-like protein 0.0019 0.0036 0.0065
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0031 0.0127 0.0127
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0599 0.4342 0.5651
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0596 0.1063
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0106 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0136 0.0907 0.157
Onchocerca volvulus 0.0099 0.0635 0.2554
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0884 0.1529
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0108 0.0132
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.1279 0.224
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.013 0.0861 0.1121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0257 0.1801 0.318
Toxoplasma gondii target of rapamycin (TOR), putative 0.025 0.1751 1
Brugia malayi Serotonin receptor 0.0453 0.3262 0.5832
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0133 0.0884 0.115
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.042 0.3014 1
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0884 0.1529
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0264 0.0413
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.009 0.0101
Brugia malayi PAS domain containing protein 0.0047 0.0247 0.0439
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0034 0.0034
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0767 0.5592 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0282 0.1991 0.3521
Loa Loa (eye worm) hypothetical protein 0.0069 0.0408 0.0531
Loa Loa (eye worm) hypothetical protein 0.0091 0.0573 0.0745
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0114 0.013
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0031 0.0127 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.025 0.1751 0.3089
Echinococcus granulosus voltage dependent calcium channel 0.0031 0.0127 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.1554 0.2733
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0145 0.0974 0.169
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0282 0.1991 0.3521
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0034 0.0059
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0058 0.033 0.1496
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0058 0.033 0.3378
Loa Loa (eye worm) hypothetical protein 0.0122 0.0801 0.1042
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.0073 0.0083
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0156 0.1861
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0283 0.2 0.3537
Loa Loa (eye worm) hypothetical protein 0.0067 0.0396 0.0515
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.016 0.0227
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.068 0.1162
Trypanosoma brucei Casein kinase II 0.0133 0.0884 0.4319
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.068 1
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.0883 0.1527
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0174 0.1186 0.1543
Onchocerca volvulus Serine\/threonine kinase homolog 0.0186 0.1279 0.5594
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0058 0.033 0.1496
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0059 0.0076
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.004 0.0196 0.033
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0537 0.3879 0.3879
Loa Loa (eye worm) hypothetical protein 0.0159 0.1074 0.1397
Brugia malayi hypothetical protein 0.0462 0.3327 0.5948
Plasmodium falciparum casein kinase 2, alpha subunit 0.0133 0.0884 0.9051
Brugia malayi hypothetical protein 0.01 0.0635 0.1134
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0145 0.0974 0.1739
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0108 0.0799
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0034 0.0034
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0108 0.0616
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0108 0.0132
Echinococcus granulosus glycogen synthase kinase 3 beta 0.005 0.0264 0.0263
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0036 0.016 0.0634
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0108 0.0132
Brugia malayi hypoxia-induced factor 1 0.0146 0.0983 0.1755
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0093 0.012
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0036 0.0361
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0073 0.0435 0.0759
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.011 0.0143
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.068 0.0781
Brugia malayi hypothetical protein 0.0019 0.0034 0.0059
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.033 0.0428
Loa Loa (eye worm) hypothetical protein 0.0048 0.0253 0.0328
Loa Loa (eye worm) phosphatidylinositol 3 0.0207 0.1432 0.1864
Leishmania major phosphatidylinositol 4-kinase, putative 0.0058 0.033 0.0849
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0245 0.1718 0.3057
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0058 0.033 0.057
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0022 0.0061 0.0069
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.009 0.0101
Giardia lamblia Kinase, CMGC GSK 0.005 0.0264 0.0537
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0145 0.0974 0.169
Loa Loa (eye worm) hypothetical protein 0.0069 0.0408 0.0531
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0036 0.016 0.0397
Schistosoma mansoni hypothetical protein 0.0024 0.0073 0.0083
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0034 0.0034
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0145 0.0974 1
Loa Loa (eye worm) hypothetical protein 0.0537 0.3879 0.5049
Loa Loa (eye worm) hypothetical protein 0.0069 0.0408 0.0531
Trichomonas vaginalis PIKK family atypical protein kinase 0.025 0.1751 0.3089
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0034 0.0034
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.1279 0.224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0257 0.1801 0.318
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.1355 0.2376
Entamoeba histolytica casein kinase, putative 0.0133 0.0884 0.1529
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0197 0.1355 0.6715
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0117
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.068 0.3281

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.011 ug ml-1 Cytotoxicity of the compound tested against drug sensitive HL60/S cell line at 5 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 0.018 ug ml-1 Cytotoxicity of the compound tested against drug sensitive HL60/S cell line at 1 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 0.023 ug ml-1 Cytotoxicity of the compound against drug sensitive HL60/S cell line at 0.5 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 0.027 ug ml-1 Cytotoxicity of the compound tested against HL60/Vinc cell line at 5 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 0.213 ug ml-1 Cytotoxicity of the compound tested against Hela C1 cells at 2.5 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 0.224 ug ml-1 Cytotoxicity of the compound tested against drug resistant HL60/ADR cell line at 5 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 0.241 ug ml-1 Cytotoxicity of the compound tested against Hela T5 cells at 2.5 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 0.315 ug ml-1 Cytotoxicity of the compound tested against Hela C1 cells at 1 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 0.444 ug ml-1 Cytotoxicity of the compound tested against HL60/Vinc cell line at 1 microM dose of LY329146 at 1 uM ChEMBL. 10612603
IC50 (functional) = 1.063 ug ml-1 Cytotoxicity of the compound tested against Hela T5 cells at 1 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 1.107 ug ml-1 Cytotoxicity of the compound against drug resistant HL60/ADR cell line at 1 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 1.44 ug ml-1 Cytotoxicity of the compound against HL60/Vinc cell line at 0.5 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 1.715 ug ml-1 Cytotoxicity of the compound tested against drug resistant HL60/ADR cell line at 0.5 microM dose of LY329146 ChEMBL. 10612603
RF (functional) = 1 Ability to enhance the cytotoxicity of doxorubicin againstdrug sensitive Hela T5 cells line expressed as reversal factor (RF) at 1 uM ChEMBL. 10612603
RF (functional) = 1.1 Ability to enhance the cytotoxicity of doxorubicin againstdrug sensitive Hela C1 cells line expressed as reversal factor (RF) at 1 uM ChEMBL. 10612603
RF (functional) = 1.2 Ability to enhance the cytotoxicity of doxorubicin againstdrug sensitive HL60/S cell line expressed as reversal factor (RF) at 0.5 uM ChEMBL. 10612603
RF (functional) = 1.3 Ability to enhance the cytotoxicity of doxorubicin againstdrug sensitive HL60/Vinc cell line expressed as reversal factor (RF) at 0.5 uM ChEMBL. 10612603
RF (functional) = 1.5 Ability to enhance the cytotoxicity of doxorubicin againstdrug sensitive HL60/S cell line expressed as reversal factor (RF) at 1 uM ChEMBL. 10612603
RF (functional) = 1.6 Ability to enhance the cytotoxicity of doxorubicin againstdrug sensitive HL60/S cell line expressed as reversal factor (RF) at 2.5 uM ChEMBL. 10612603
RF (functional) = 1.7 Ability to enhance the cytotoxicity of doxorubicin againstdrug sensitive HL60/ADR cell line expressed as reversal factor (RF) at 0.5 uM ChEMBL. 10612603
RF (functional) = 2.4 Ability to enhance the cytotoxicity of doxorubicin against drug sensitive HL60/S cell line expressed as reversal factor (RF) at 5 uM ChEMBL. 10612603
RF (functional) = 2.7 Ability to enhance the cytotoxicity of doxorubicin againstdrug sensitive HL60/ADR cell line expressed as reversal factor (RF) at 1 uM ChEMBL. 10612603
RF (functional) = 2.9 Ability to enhance the cytotoxicity of doxorubicin againstdrug sensitive Hela T5 cells line expressed as reversal factor (RF) at 2.5 uM ChEMBL. 10612603
RF (functional) = 4.2 Ability to enhance the cytotoxicity of doxorubicin againstdrug sensitive HL60/Vinc cell line expressed as reversal factor (RF) at 1 uM ChEMBL. 10612603
RF (functional) = 13.3 Ability to enhance the cytotoxicity of doxorubicinagainst drug resistant HL60/ADR cell line expressed as reversal factor (RF) at 5 uM ChEMBL. 10612603
RF (functional) = 69 Ability to enhance the cytotoxicity of doxorubicin againstdrug sensitive HL60/Vinc cell line expressed as reversal factor (RF) at 5 uM ChEMBL. 10612603

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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