Detailed information for compound 410076

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 412.527 | Formula: C19H36N6O4
  • H donors: 6 H acceptors: 4 LogP: 0.67 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@H](C(=O)O)CCCNC(=N)N)CCCCCNC(=O)NC1CCCCC1
  • InChi: 1S/C19H36N6O4/c20-18(21)22-13-7-10-15(17(27)28)25-16(26)11-5-2-6-12-23-19(29)24-14-8-3-1-4-9-14/h14-15H,1-13H2,(H,25,26)(H,27,28)(H4,20,21,22)(H2,23,24,29)/t15-/m0/s1
  • InChiKey: OYLWOZUPLOPKMO-HNNXBMFYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus epoxide hydrolase 2, cytoplasmic Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) Get druggable targets OG5_129061 All targets in OG5_129061
Mycobacterium ulcerans epoxide hydrolase EphA Get druggable targets OG5_129061 All targets in OG5_129061
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Putative nachr subunit 0.0319 0.4715 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.01 0.1417 0.4917
Leishmania major trypanothione reductase 0.004 0.0497 0.725
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Brugia malayi major facilitator superfamily protein 0.0017 0.0152 0.0202
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.003 0.0051
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0301 0.4383
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0106 0.1547
Mycobacterium tuberculosis Probable reductase 0.009 0.1264 0.4388
Echinococcus granulosus nAChR subunit 0.0172 0.2493 0.4182
Plasmodium vivax glutathione reductase, putative 0.004 0.0497 0.0659
Loa Loa (eye worm) hypothetical protein 0.0053 0.0704 0.0704
Loa Loa (eye worm) hypothetical protein 0.0017 0.0152 0.0152
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0106 0.1547
Plasmodium falciparum glutathione reductase 0.004 0.0497 0.0659
Entamoeba histolytica hypothetical protein 0.0037 0.0453 0.1817
Toxoplasma gondii cytochrome p450 superfamily protein 0.0007 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0029 0.0338 0.0338
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0528 0.7705
Loa Loa (eye worm) hypothetical protein 0.0172 0.2493 0.2493
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0606 0.0606
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Schistosoma mansoni flap endonuclease-1 0.0024 0.0261 0.0438
Plasmodium vivax sugar transporter, putative 0.0017 0.0152 0.0201
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0453 0.076
Echinococcus granulosus tar DNA binding protein 0.0066 0.0889 0.1492
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0457 0.6665
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0007 0.0009 0.0033
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0152 0.0202
Loa Loa (eye worm) CYP4Cod1 0.0007 0.0009 0.0009
Brugia malayi Cytochrome P450 family protein 0.0007 0.0009 0.0012
Schistosoma mansoni glucose transport protein 0.0119 0.1699 0.2851
Loa Loa (eye worm) hypothetical protein 0.0319 0.4715 0.4715
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0172 0.2493 0.4182
Trypanosoma brucei glucose transporter, putative 0.0037 0.0457 0.6665
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0319 0.4715 0.4715
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0106 0.1547
Echinococcus multilocularis solute carrier family 22 0.0017 0.0152 0.0255
Loa Loa (eye worm) hypothetical protein 0.0147 0.212 0.212
Loa Loa (eye worm) hypothetical protein 0.0147 0.212 0.212
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0889 0.0889
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0106 0.1547
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0301 0.04
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0007 0.0009 0.0033
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0319 0.4715 0.7909
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0301 0.0504
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0147 0.212 0.3557
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0184 0.2685 0.4504
Schistosoma mansoni hypothetical protein 0.0285 0.4197 0.704
Loa Loa (eye worm) hypothetical protein 0.0147 0.212 0.212
Brugia malayi Sugar transporter family protein 0.0017 0.0152 0.0202
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0147 0.212 0.3557
Loa Loa (eye worm) hypothetical protein 0.0172 0.2493 0.2493
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.03 0.4372
Brugia malayi hypothetical protein 0.0017 0.0152 0.0202
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0037 0.045 0.0903
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0106 0.6987
Schistosoma mansoni hypothetical protein 0.0023 0.0252 0.0422
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0152 0.0894
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0027 0.0301 0.0301
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0007 0.0009 0.0033
Loa Loa (eye worm) hypothetical protein 0.0017 0.0152 0.0152
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0007 0.0009 0.0033
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0319 0.4715 0.4715
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.03 0.1765
Plasmodium falciparum calcium-dependent protein kinase 3 0.0037 0.045 0.0597
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.0106 0.0213
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.0106 0.0624
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.0106 0.1547
Loa Loa (eye worm) hypothetical protein 0.0017 0.0152 0.0152
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0686 0.1376
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0319 0.4715 0.7909
Schistosoma mansoni glucose transport protein 0.0119 0.1699 0.2851
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0017 0.0152 0.0527
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.024 0.1695
Loa Loa (eye worm) hypothetical protein 0.0147 0.212 0.212
Loa Loa (eye worm) hypothetical protein 0.0147 0.212 0.212
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0705 0.1414
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0453 0.076
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0319 0.4715 0.7909
Brugia malayi hypothetical protein 0.0034 0.0407 0.0542
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0319 0.4715 0.4715
Mycobacterium ulcerans integral membrane transport protein 0.0017 0.0152 0.0527
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0106 0.1547
Brugia malayi Thioredoxin reductase 0.004 0.0497 0.0662
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0704 0.118
Trypanosoma brucei sugar transporter, putative 0.0017 0.0152 0.2214
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.1699 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0017 0.0152 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0007 0.0009 0.0033
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0528 0.7705
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0036 0.0439 0.0736
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0106 0.1547
Brugia malayi Cation transporter family protein 0.0319 0.4715 0.6276
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0301 0.0504
Onchocerca volvulus 0.0047 0.0606 0.0995
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0017 0.0152 0.0255
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0036 0.045 0.0599
Loa Loa (eye worm) hypothetical protein 0.0017 0.0152 0.0152
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.009 0.1264 0.4388
Toxoplasma gondii protein kinase, putative 0.0337 0.4987 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0319 0.4715 0.6276
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0457 0.6665
Echinococcus granulosus glycine receptor subunit alpha 1 0.0319 0.4715 0.7909
Brugia malayi excitatory GABA receptor EXP-1A 0.0319 0.4715 0.6276
Schistosoma mansoni sugar transporter 0.0017 0.0152 0.0255
Leishmania major glucose transporter/membrane transporter D2, putative 0.0037 0.0457 0.6665
Loa Loa (eye worm) hypothetical protein 0.0036 0.0439 0.0439
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0686 0.0909
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0172 0.2493 0.2493
Plasmodium falciparum calcium-dependent protein kinase 2 0.0037 0.045 0.0597
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.03 0.0601
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0147 0.212 0.212
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0014 0.0106 0.0141
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0014 0.0106 0.0368
Trypanosoma brucei glucose transporter, putative 0.0037 0.0457 0.6665
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0319 0.4715 0.7909
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0319 0.4715 0.6276
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0047 0.0606 0.0606
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.03 0.0398
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.0106 0.1547
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0301 0.1769
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0319 0.4715 0.7909
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0152 0.0894
Schistosoma mansoni nAChR subunit 0.0319 0.4715 0.7909
Brugia malayi Flap endonuclease-1 0.0027 0.03 0.0399
Brugia malayi Cation transporter family protein 0.0319 0.4715 0.6276
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0147 0.212 0.3557
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0036 0.045 0.045
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0324 0.0324
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0007 0.0009 0.0033
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0301 0.0603
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0193 0.2809 0.5632
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0014 0.0106 0.353
Loa Loa (eye worm) hypothetical protein 0.0172 0.2493 0.2493
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0319 0.4715 0.6276
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0319 0.4715 0.7909
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0457 0.269
Plasmodium falciparum proline--tRNA ligase 0.0042 0.0528 0.0701
Schistosoma mansoni nAChR subunit 0.0319 0.4715 0.7909
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.0106 0.1547
Brugia malayi cytochrome P450 0.0007 0.0009 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0457 0.269
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0251 0.1477
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0147 0.212 0.2822
Onchocerca volvulus 0.0319 0.4715 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0319 0.4715 0.6276
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Leishmania major cytochrome p450-like protein 0.0007 0.0009 0.0137
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0007 0.0009 0.0033
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0193 0.2809 0.3724
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0301 0.1044
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0106 0.0141
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0252 0.0422
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0319 0.4715 0.7909
Echinococcus granulosus calcium dependent protein kinase 0.0034 0.0416 0.0698
Brugia malayi Cytochrome P450 family protein 0.0007 0.0009 0.0012
Entamoeba histolytica Flap nuclease, putative 0.0027 0.03 0.1203
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0119 0.1699 0.2851
Loa Loa (eye worm) hypothetical protein 0.0036 0.045 0.045
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0889 0.1184
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0457 0.269
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0457 0.269
Echinococcus multilocularis tumor protein p63 0.0332 0.4908 0.8231
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.024 0.0833
Leishmania major hypothetical protein, conserved 0.0052 0.0686 1
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0301 0.0399
Loa Loa (eye worm) hypothetical protein 0.0017 0.0152 0.0152
Plasmodium falciparum protein kinase 6 0.0506 0.7542 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.212 0.212
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0007 0.0009 0.0033
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0319 0.4715 0.6276
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.009 0.1264 0.4388
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.045 0.0755
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0528 0.7705
Echinococcus multilocularis solute carrier family 22 0.0017 0.0152 0.0255
Schistosoma mansoni protein kinase 0.0036 0.045 0.0755
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0606 0.1016
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0007 0.0009 0.0033
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0606 0.1016
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0007 0.0009 0.0033
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0172 0.2493 0.3319
Echinococcus multilocularis solute carrier family 22 0.0017 0.0152 0.0255
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0704 0.118
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.045 0.0755
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0889 0.1492
Schistosoma mansoni neurotransmitter gated ion channel 0.0147 0.212 0.3557
Leishmania major glucose transporter, lmgt2 0.0037 0.0457 0.6665
Giardia lamblia Sugar-proton symporter 0.0017 0.0152 0.346
Echinococcus granulosus solute carrier family 22 0.0017 0.0152 0.0255
Brugia malayi hypothetical protein 0.0147 0.212 0.2822
Schistosoma mansoni glucose transporter 0.0017 0.0152 0.0255
Onchocerca volvulus 0.0319 0.4715 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.045 0.0755
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0457 0.269
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0119 0.1699 0.2851
Plasmodium falciparum calcium-dependent protein kinase 5 0.0037 0.045 0.0597
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0007 0.0009 0.0033
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0319 0.4715 0.4715
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0686 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Brugia malayi RNA binding protein 0.0066 0.0889 0.1184
Echinococcus granulosus glycine receptor subunit beta 0.0319 0.4715 0.7909
Echinococcus granulosus cytochrome P450 2K1 0.0007 0.0009 0.0016
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.003 0.0051
Loa Loa (eye worm) hypothetical protein 0.0319 0.4715 0.4715
Entamoeba histolytica hypothetical protein 0.0037 0.0453 0.1817
Toxoplasma gondii facilitative glucose transporter GT1 0.0119 0.1699 0.3408
Plasmodium falciparum thioredoxin reductase 0.0014 0.0106 0.0141
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0147 0.212 0.3557
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0007 0.0009 0.0033
Schistosoma mansoni glucose transport protein 0.0119 0.1699 0.2851
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0505 0.0848
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0007 0.0009 0.0137
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0004 0.0007
Loa Loa (eye worm) RNA binding protein 0.0066 0.0889 0.0889
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0036 0.045 0.0755
Trypanosoma cruzi hexose transporter, putative 0.002 0.0204 0.2974
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0007 0.0009 0.0033
Brugia malayi hypothetical protein 0.0017 0.0152 0.0202
Loa Loa (eye worm) hypothetical protein 0.0017 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0319 0.4715 0.4715
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0007 0.0009 0.0033
Loa Loa (eye worm) hypothetical protein 0.0147 0.212 0.212
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0119 0.1699 0.2851
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0147 0.212 0.2822
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0007 0.0009 0.0033
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0301 0.4383
Echinococcus granulosus General substrate transporter 0.0102 0.1446 0.2426
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0037 0.045 0.0903
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0686 0.0909
Schistosoma mansoni neurotransmitter gated ion channel 0.0147 0.212 0.3557
Leishmania major hypothetical protein, conserved 0.0017 0.0152 0.2214
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0301 0.6849
Schistosoma mansoni cytochrome P450 0.0007 0.0009 0.0016
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0319 0.4715 0.7909
Loa Loa (eye worm) hypothetical protein 0.0147 0.212 0.212
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0017 0.0152 0.0255
Loa Loa (eye worm) MBCTL1 0.0053 0.0704 0.0704
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0457 0.6665
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.03 0.4372
Mycobacterium tuberculosis Probable dehydrogenase 0.009 0.1264 0.4388
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0172 0.2493 0.3319
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0014 0.0106 0.0368
Schistosoma mansoni hypothetical protein 0.0037 0.0453 0.076
Echinococcus granulosus flap endonuclease 1 0.0027 0.03 0.0503
Schistosoma mansoni cpg binding protein 0.0028 0.0324 0.0544
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Schistosoma mansoni cpg binding protein 0.003 0.0349 0.0585
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.009 0.1264 0.8924
Schistosoma mansoni cpg binding protein 0.003 0.0349 0.0585
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0106 0.1547
Plasmodium falciparum hexose transporter 0.0119 0.1699 0.2253
Leishmania major glucose transporter, lmgt3 0.0037 0.0457 0.6665
Schistosoma mansoni hypothetical protein 0.0401 0.5962 1
Schistosoma mansoni nAChR subunit 0.0319 0.4715 0.7909
Plasmodium falciparum protein kinase 7 0.0337 0.4987 0.6612
Schistosoma mansoni acetylcholine receptor-related 0.0147 0.212 0.3557
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0004 0.0007
Loa Loa (eye worm) acetylcholine receptor protein 0.0147 0.212 0.212
Loa Loa (eye worm) hypothetical protein 0.0017 0.0152 0.0152
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.0106 0.0213
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0152 0.2214
Echinococcus multilocularis solute carrier family 22 0.0017 0.0152 0.0255
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0007 0.0009 0.0033
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0036 0.0439 0.176
Echinococcus multilocularis glycine receptor subunit beta 0.0319 0.4715 0.7909
Giardia lamblia Prolyl-tRNA synthetase 0.0036 0.0439 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0152 0.0152
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0029 0.0038
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0036 0.045 0.045
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0017 0.0152 0.0527
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0319 0.4715 0.7909
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.03 0.4372
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0007 0.0009 0.0033
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0301 1
Onchocerca volvulus 0.0319 0.4715 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0152 0.0894
Schistosoma mansoni acetylcholine receptor subunit beta 0.0147 0.212 0.3557
Loa Loa (eye worm) hypothetical protein 0.0147 0.212 0.212
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0007 0.0009 0.0033
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0106 0.1547
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0606 0.1016
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0014 0.0106 0.0368
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0889 0.0889
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0319 0.4715 0.6276
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0504 0.7513 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0036 0.045 0.6562
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0014 0.0106 0.0141
Leishmania major protein kinase, putative 0.0036 0.045 0.6562
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0.0009 0.0137
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0007 0.0009 0.0033
Schistosoma mansoni nAChR subunit 0.0319 0.4715 0.7909
Brugia malayi glutathione reductase 0.004 0.0497 0.0662
Loa Loa (eye worm) hypothetical protein 0.0017 0.0152 0.0152
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0457 0.269
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Trypanosoma cruzi glucose transporter, putative 0.0017 0.0152 0.2214
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0172 0.2493 0.4182
Loa Loa (eye worm) hypothetical protein 0.0319 0.4715 0.4715
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.009 0.0311
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0319 0.4715 0.7909
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0147 0.212 0.2822
Loa Loa (eye worm) hypothetical protein 0.0017 0.0152 0.0152
Onchocerca volvulus 0.0147 0.212 0.4314
Onchocerca volvulus 0.0028 0.0324 0.0378
Trypanosoma brucei trypanothione reductase 0.004 0.0497 0.725
Loa Loa (eye worm) hypothetical protein 0.0319 0.4715 0.4715
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0007 0.0009 0.0033
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.045 0.0755
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0106 0.1547
Onchocerca volvulus 0.0319 0.4715 1
Onchocerca volvulus 0.0172 0.2493 0.5131
Brugia malayi hypothetical protein 0.0052 0.0686 0.0913
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0606 0.1016
Trypanosoma brucei glucose transporter, putative 0.0037 0.0457 0.6665
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0119 0.1699 0.2851
Loa Loa (eye worm) hypothetical protein 0.0319 0.4715 0.4715
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0007 0.0009 0.0033
Loa Loa (eye worm) hypothetical protein 0.0319 0.4715 0.4715
Loa Loa (eye worm) hypothetical protein 0.0172 0.2493 0.2493
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0036 0.0439 0.2583
Schistosoma mansoni sugar transporter 0.0017 0.0152 0.0255
Leishmania major glucose transporter, lmgt1 0.0037 0.0457 0.6665
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Loa Loa (eye worm) hypothetical protein 0.0172 0.2493 0.2493
Loa Loa (eye worm) hypothetical protein 0.0319 0.4715 0.4715
Brugia malayi mbt repeat family protein 0.0047 0.0606 0.0806
Brugia malayi hypothetical protein 0.0017 0.0152 0.0202
Plasmodium falciparum glutathione reductase 0.0014 0.0106 0.0141
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0007 0.0009 0.0137
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0119 0.1699 0.2851
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0497 0.0497
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0152 0.0152
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0505 0.0848
Toxoplasma gondii sugar transporter ST3 0.0017 0.0152 0.0305
Schistosoma mansoni nAChR subunit 0.0147 0.212 0.3557
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0686 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0319 0.4715 0.4715
Schistosoma mansoni sugar transporter 0.0017 0.0152 0.0255
Loa Loa (eye worm) hypothetical protein 0.0319 0.4715 0.4715
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0319 0.4715 0.7909
Mycobacterium leprae putative cytochrome p450 0.0007 0.0009 0.0066
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.045 0.0755
Plasmodium vivax proline--tRNA ligase, putative 0.0042 0.0528 0.0701
Loa Loa (eye worm) hypothetical protein 0.0147 0.212 0.212
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0147 0.212 0.2822
Loa Loa (eye worm) hypothetical protein 0.0036 0.0439 0.0439
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0704 0.118
Echinococcus multilocularis glycine receptor subunit beta 0.0319 0.4715 0.7909
Echinococcus granulosus Sugar transporter ERD6 protein 0.0017 0.0152 0.0255
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0197 0.2881 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.0017 0.0152 0.0255
Entamoeba histolytica hypothetical protein 0.0037 0.0453 0.1817
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Schistosoma mansoni hypothetical protein 0.0119 0.1699 0.2851
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0301 0.0504
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0007 0.0009 0.0033
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0606 0.0995
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0704 0.118
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.045 0.0597
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0007 0.0009 0.0033
Trypanosoma cruzi sugar transporter, putative 0.0017 0.0152 0.2214
Plasmodium vivax calcium-dependent protein kinase, putative 0.0037 0.045 0.0597
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0007 0.0009 0.0033
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0106 0.0178
Echinococcus multilocularis cpg binding protein 0.003 0.0349 0.0585
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0007 0.0009 0.0033
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0007 0.0009 0.0033
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0319 0.4715 0.7909
Plasmodium falciparum thioredoxin reductase 0.004 0.0497 0.0659
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0889 0.1492
Toxoplasma gondii transporter, major facilitator family protein 0.0017 0.0152 0.0305
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0007 0.0009 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0152 0.0894
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.01 0.1417 1
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0606 0.1016
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0147 0.212 0.2822
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0319 0.4715 0.7909
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0528 0.7705
Loa Loa (eye worm) hypothetical protein 0.0147 0.212 0.212
Plasmodium falciparum calcium-dependent protein kinase 1 0.0037 0.045 0.0597
Trypanosoma cruzi hexose transporter 0.0037 0.0457 0.6665
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0301 0.0504
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0147 0.212 0.212
Loa Loa (eye worm) histone methyltransferase 0.0009 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0319 0.4715 0.4715
Schistosoma mansoni nAChR subunit 0.0319 0.4715 0.7909
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0152 0.0894
Mycobacterium tuberculosis Probable oxidoreductase 0.01 0.1417 0.4917
Trichomonas vaginalis sugar transport protein, putative 0.0017 0.0152 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Brugia malayi hypothetical protein 0.0147 0.212 0.2822
Trypanosoma brucei cytochrome P450, putative 0.0007 0.0009 0.0137
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0152 0.0202
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0106 0.0178
Trypanosoma brucei glucose transporter 1E 0.0037 0.0457 0.6665
Schistosoma mansoni nAChR subunit 0.0319 0.4715 0.7909
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Plasmodium falciparum mitogen-activated protein kinase 2 0.0193 0.2809 0.3724
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0007 0.0009 0.0033
Loa Loa (eye worm) ACC-1 protein 0.0319 0.4715 0.4715
Plasmodium vivax CDK-related protein kinase 6, putative 0.0506 0.7542 1
Loa Loa (eye worm) hypothetical protein 0.0357 0.5291 0.5291
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0319 0.4715 0.6276
Loa Loa (eye worm) hypothetical protein 0.0017 0.0152 0.0152
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0319 0.4715 0.6276
Brugia malayi Cam kinase protein 1 0.0036 0.045 0.0599
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.009 0.1264 0.4388
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0042 0.0528 0.106
Loa Loa (eye worm) sugar transporter 0.0119 0.1699 0.1699
Brugia malayi Cation transporter family protein 0.0319 0.4715 0.6276
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.045 0.0755
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0528 0.7705
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0686 1
Schistosoma mansoni nAChR subunit 0.0147 0.212 0.3557
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Echinococcus granulosus glycine receptor subunit beta 0.0319 0.4715 0.7909
Trichomonas vaginalis glucose transporter, putative 0.0017 0.0152 0.0894
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0889 0.1492
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0017 0.0152 0.2214
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.024 0.0833
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0106 0.1547
Onchocerca volvulus 0.0319 0.4715 1
Brugia malayi hypothetical protein 0.0147 0.212 0.2822
Brugia malayi Sugar transporter family protein 0.0017 0.0152 0.0202
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0686 0.0909
Echinococcus granulosus glycine receptor subunit alpha 1 0.0319 0.4715 0.7909
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0119 0.1699 0.2851
Schistosoma mansoni neurotransmitter gated ion channel 0.0172 0.2493 0.4182
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0106 0.1547
Echinococcus granulosus solute carrier family 22 0.0017 0.0152 0.0255
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0152 0.0202
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0119 0.1699 0.2851
Loa Loa (eye worm) glutathione reductase 0.004 0.0497 0.0497
Onchocerca volvulus 0.0049 0.0632 0.1052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0152 0.0152
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0457 0.6665
Loa Loa (eye worm) GABA receptor subunit 0.0172 0.2493 0.2493
Loa Loa (eye worm) hypothetical protein 0.0319 0.4715 0.4715
Onchocerca volvulus 0.0147 0.212 0.4314
Trypanosoma brucei glucose transporter, putative 0.0037 0.0457 0.6665
Giardia lamblia NADH oxidase lateral transfer candidate 0.0014 0.0106 0.2418
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0457 0.6665
Loa Loa (eye worm) cytochrome P450 0.0007 0.0009 0.0009
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0037 0.045 0.0597
Loa Loa (eye worm) hypothetical protein 0.0017 0.0152 0.0152
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0319 0.4715 0.6276
Schistosoma mansoni hypothetical protein 0.0007 0.0009 0.0016
Echinococcus granulosus dnaJ subfamily B 0.0401 0.5962 1
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0007 0.0009 0.0033
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0439 0.0736
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0036 0.0439 0.0736
Loa Loa (eye worm) hypothetical protein 0.0017 0.0152 0.0152
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0007 0.0009 0.0033
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0606 0.1016
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0037 0.045 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0009 0.0009
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0017 0.0152 0.0527
Loa Loa (eye worm) hypothetical protein 0.0172 0.2493 0.2493
Loa Loa (eye worm) hypothetical protein 0.0319 0.4715 0.4715
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0319 0.4715 0.7909
Trypanosoma cruzi cytochrome P450, putative 0.0007 0.0009 0.0137
Onchocerca volvulus 0.0319 0.4715 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0106 0.1547
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0004 0.0007
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0301 0.1044
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0319 0.4715 0.7909
Loa Loa (eye worm) hypothetical protein 0.0319 0.4715 0.4715
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0051 0.0068
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0036 0.0439 0.3099
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0319 0.4715 0.6276
Echinococcus granulosus glycine receptor subunit alpha 1 0.0319 0.4715 0.7909
Trypanosoma brucei glucose transporter, putative 0.0037 0.0457 0.6665
Giardia lamblia Hexose transporter 0.0017 0.0152 0.346
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0147 0.212 0.2822
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.045 0.0755
Loa Loa (eye worm) hypothetical protein 0.0052 0.0686 0.0686
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0319 0.4715 0.6276
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0632 0.106
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0889 0.1492
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0889 0.1492
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0319 0.4715 0.7909
Mycobacterium leprae Conserved hypothetical protein 0.0007 0.0009 0.0066
Echinococcus granulosus solute carrier family 22 0.0017 0.0152 0.0255
Loa Loa (eye worm) hypothetical protein 0.0319 0.4715 0.4715
Echinococcus multilocularis flap endonuclease 1 0.0027 0.03 0.0503
Brugia malayi CXXC zinc finger family protein 0.0028 0.0324 0.0432
Echinococcus granulosus tumor protein p63 0.0332 0.4908 0.8231
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0497 0.1726
Brugia malayi TAR-binding protein 0.0066 0.0889 0.1184
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0106 0.6987
Leishmania major myo-inositol/proton symporter (MIT) 0.0017 0.0152 0.2214
Trypanosoma cruzi cytochrome P450, putative 0.0007 0.0009 0.0137
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0301 0.4383
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Mycobacterium ulcerans epoxide hydrolase EphA 0.0197 0.2881 1
Treponema pallidum NADH oxidase 0.0014 0.0106 1
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.03 0.6832
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0439 0.0736
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0036 0.0439 0.0584
Loa Loa (eye worm) hypothetical protein 0.0147 0.212 0.212
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0009 0.0009
Mycobacterium tuberculosis Putative ferredoxin reductase 0.009 0.1264 0.4388
Schistosoma mansoni protein kinase 0.0036 0.045 0.0755
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0017 0.0152 0.0201
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0704 0.118
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.5962 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Loa Loa (eye worm) hypothetical protein 0.0147 0.212 0.212
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0457 0.6665
Trypanosoma brucei glucose transporter, putative 0.0037 0.0457 0.6665
Schistosoma mansoni nAChR subunit 0.0319 0.4715 0.7909
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0007 0.0009 0.0033
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0319 0.4715 0.7909
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0301 0.0399
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0319 0.4715 0.7909
Plasmodium falciparum flap endonuclease 1 0.0027 0.03 0.0398
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0014 0.0106 0.0141
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0606 0.1016
Plasmodium falciparum calcium-dependent protein kinase 4 0.0037 0.045 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0007 0.0009 0.0137
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0007 0.0009 0.0033
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0007 0.0009 0.0033
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0184 0.2685 0.4504
Loa Loa (eye worm) LGC-31 protein 0.0319 0.4715 0.4715
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0051 0.0068
Entamoeba histolytica hypothetical protein 0.0027 0.0301 0.1206
Echinococcus granulosus synaptic vesicle 2 protein 0.0017 0.0152 0.0255
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0319 0.4715 0.7909
Loa Loa (eye worm) hypothetical protein 0.0049 0.0632 0.0632
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0453 0.076
Brugia malayi Cytochrome P450 family protein 0.0007 0.0009 0.0012
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0319 0.4715 0.6276
Loa Loa (eye worm) ACC-1 protein 0.0319 0.4715 0.4715
Brugia malayi Sugar transporter family protein 0.0119 0.1699 0.2262
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0319 0.4715 0.7909
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0147 0.212 0.3557
Trypanosoma brucei glucose transporter, putative 0.0037 0.0457 0.6665
Leishmania major cytochrome p450-like protein 0.0007 0.0009 0.0137
Loa Loa (eye worm) hypothetical protein 0.0319 0.4715 0.4715
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0319 0.4715 0.7909
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0014 0.0106 0.0141
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0457 0.269
Entamoeba histolytica protein kinase, putative 0.0036 0.045 0.1805
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.01 0.1417 0.4917
Onchocerca volvulus 0.0172 0.2493 0.5131
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0007 0.0009 0.0033
Schistosoma mansoni protein kinase 0.0036 0.045 0.0755
Echinococcus granulosus cpg binding protein 0.003 0.0349 0.0585
Echinococcus granulosus solute carrier family 22 0.0017 0.0152 0.0255
Brugia malayi Cytochrome P450 family protein 0.0027 0.0308 0.041
Trypanosoma brucei glucose transporter, putative 0.0037 0.0457 0.6665
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0172 0.2493 0.3319
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0319 0.4715 0.7909
Loa Loa (eye worm) sugar transporter 0.0017 0.0152 0.0152
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Loa Loa (eye worm) hypothetical protein 0.0172 0.2493 0.2493
Toxoplasma gondii sugar transporter ST2 0.0017 0.0152 0.0305
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0252 0.0422
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0106 0.0178
Echinococcus multilocularis General substrate transporter 0.0102 0.1446 0.2426
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.009 0.8435
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0007 0.0009 0.0033
Brugia malayi major facilitator superfamily protein 0.0017 0.0152 0.0202
Entamoeba histolytica hypothetical protein 0.0172 0.2493 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0017 0.0152 0.0527
Onchocerca volvulus 0.0147 0.212 0.4314
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0007 0.0009 0.0033
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0301 0.2122
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0802 0.1345
Brugia malayi hypothetical protein 0.0147 0.212 0.2822
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0319 0.4715 0.4715
Toxoplasma gondii thioredoxin reductase 0.004 0.0497 0.0997
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0319 0.4715 0.6276
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0319 0.4715 0.7909
Plasmodium vivax hexose transporter 0.0119 0.1699 0.2253
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.0106 0.1547
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0037 0.045 0.0903
Brugia malayi hypothetical protein 0.0147 0.212 0.2822
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Loa Loa (eye worm) hypothetical protein 0.0319 0.4715 0.4715
Chlamydia trachomatis proline--tRNA ligase 0.0013 0.009 0.2978
Brugia malayi mbt repeat family protein 0.0047 0.0606 0.0806
Toxoplasma gondii sugar transporter ST1 0.0017 0.0152 0.0305
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0119 0.1699 0.2851
Loa Loa (eye worm) hypothetical protein 0.0017 0.0152 0.0152
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0319 0.4715 0.6276
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0014 0.0106 0.0368
Schistosoma mansoni sugar transporter 0.0017 0.0152 0.0255
Loa Loa (eye worm) hypothetical protein 0.0504 0.7513 0.7513
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.045 0.0755
Brugia malayi hypothetical protein 0.0037 0.0453 0.0603
Trichomonas vaginalis myo-inositol transporter, putative 0.0017 0.0152 0.0894
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0004 0.0007
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0007 0.0009 0.0033
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Leishmania major cytochrome p450-like protein 0.0007 0.0009 0.0137
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.0106 0.0624
Echinococcus multilocularis 0.0007 0.0009 0.0016
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0497 0.0659
Loa Loa (eye worm) hypothetical protein 0.0147 0.212 0.212
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0007 0.0009 0.0033
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0106 0.1547
Echinococcus granulosus nAChR subunit 0.0319 0.4715 0.7909
Loa Loa (eye worm) hypothetical protein 0.0319 0.4715 0.4715
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.045 0.2648
Loa Loa (eye worm) hypothetical protein 0.0147 0.212 0.212
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0319 0.4715 0.7909
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0497 0.725
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0007 0.0009 0.0033
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0.0009 0.0137
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0704 0.0937
Mycobacterium ulcerans sugar transporter 0.0017 0.0152 0.0527
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0007 0.0009 0.0033
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0036 0.0439 0.0584
Entamoeba histolytica protein kinase, putative 0.0036 0.045 0.1805
Echinococcus multilocularis calcium dependent protein kinase 0.0034 0.0416 0.0698
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0172 0.2493 0.3319
Entamoeba histolytica hypothetical protein 0.0037 0.0453 0.1817
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Echinococcus multilocularis nAChR subunit 0.0172 0.2493 0.4182
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0319 0.4715 0.6276
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0152 0.0894
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0889 0.1492
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0015 0.012 0.012
Trypanosoma brucei glucose transporter 2A 0.0037 0.0457 0.6665
Echinococcus multilocularis nAChR subunit 0.0319 0.4715 0.7909
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0308 0.0308
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0007 0.0009 0.0033

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.23 uM Inhibition of mouse recombinant soluble Epoxide hydrolase ChEMBL. 16908134
IC50 (binding) = 0.23 uM Inhibition of mouse recombinant soluble Epoxide hydrolase ChEMBL. 16908134
IC50 (binding) > 100 uM Inhibition of human recombinant soluble Epoxide hydrolase ChEMBL. 16908134
IC50 (binding) > 100 uM Inhibition of human recombinant soluble Epoxide hydrolase ChEMBL. 16908134
Solubility > 500 uM Solubility in sodium phosphate buffer at pH 7.4 ChEMBL. 16908134

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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