TDR Targets

Basic information

Technical information

TDR Targets ID: 417730
Name: 5-ethyl-3-(4-methylphenyl)sulfonyl-5-phenylim idazolidine-2,4-dione
MW: 358.412 | Formula: C18H18N2O4S
H donors: 1 H acceptors: 4 LogP: 3.04 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCC1(NC(=O)N(C1=O)S(=O)(=O)c1ccc(cc1)C)c1ccccc1
InChi: 1S/C18H18N2O4S/c1-3-18(14-7-5-4-6-8-14)16(21)20(17(22)19-18)25(23,24)15-11-9-13(2)10-12-15/h4-12H,3H2,1-2H3,(H,19,22)
InChiKey: UBOYWZGGYJNWIT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-ethyl-5-phenyl-3-(p-tolylsulfonyl)imidazolidine-2,4-dione
5-ethyl-3-(4-methylphenyl)sulfonyl-5-phenyl-imidazolidine-2,4-dione
5-ethyl-5-phenyl-3-tosyl-hydantoin
5-ethyl-3-(4-methylphenyl)sulfonyl-5-phenyl-hydantoin

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0032	0.0163	0.0165
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0032	0.0163	0.0165
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0032	0.0163	0.0163
Entamoeba histolytica	protein kinase, putative	0.0039	0.0295	0.0298
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0131	0.1955	0.2981
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0059	0.0664	0.0783
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0032	0.0163	0.0163
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0664	0.067
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0032	0.0163	0.0165
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0086	0.115	0.115
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0039	0.0295	0.0206
Schistosoma mansoni	serine/threonine-protein kinase	0.0385	0.6558	1
Echinococcus granulosus	calcium dependent secretion activator 1	0.0032	0.0163	0.0163
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0059	0.0664	0.067
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0032	0.0163	0.0165
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0192	0.307	0.307
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0326	0.0329
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.0664	0.1013
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0163	0.0165
Trypanosoma brucei	protein kinase, putative	0.0039	0.0295	0.0298
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0039	0.0295	0.0298
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0163	0.0165
Echinococcus multilocularis	RNA directed DNA polymerase	0.0041	0.0326	0.0497
Giardia lamblia	Kinase, CMGC GSK	0.0106	0.1501	0.1573
Echinococcus multilocularis	oxysterol binding protein 3	0.0032	0.0163	0.0249
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0158	0.2442	0.2464
Brugia malayi	Hr1 repeat family protein	0.0192	0.307	0.3099
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0192	0.307	0.307
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0106	0.1501	0.2509
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0032	0.0163	0.0165
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0248	0.4087	0.6232
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0032	0.0163	0.0175
Brugia malayi	Protein kinase c protein 2	0.0063	0.0735	0.0742
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0192	0.307	0.3099
Trypanosoma brucei	PH domain containing protein, putative	0.0032	0.0163	0.0165
Echinococcus granulosus	epidermal growth factor receptor	0.0158	0.2442	0.2442
Entamoeba histolytica	protein kinase, putative	0.0192	0.307	0.3099
Trichomonas vaginalis	AGC family protein kinase	0.057	0.9909	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0385	0.6558	0.6618
Schistosoma mansoni	protein kinase	0.0137	0.2067	0.3152
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0032	0.0163	0.0163
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0059	0.0664	0.0783
Entamoeba histolytica	PH domain containing protein	0.0032	0.0163	0.0165
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0049	0.0481	0.0485
Trichomonas vaginalis	centaurin/arf, putative	0.0032	0.0163	0.0165
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0032	0.0163	0.0249
Echinococcus granulosus	Glutaredoxin protein 5	0.0346	0.5851	0.5851
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0032	0.0163	0.0163
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0131	0.1955	0.1955
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0385	0.6558	1
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0032	0.0163	0.0249
Toxoplasma gondii	hypothetical protein	0.0032	0.0163	0.0175
Brugia malayi	Uncoordinated protein 104	0.0032	0.0163	0.0165
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.0123	0.1824	0.1824
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0039	0.0295	0.0206
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0032	0.0163	0.0249
Leishmania major	protein kinase, putative	0.0039	0.0295	0.1508
Echinococcus multilocularis	Glutaredoxin protein 5	0.0346	0.5851	0.8922
Loa Loa (eye worm)	syntrophin-1	0.0032	0.0163	0.0165
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0059	0.0664	0.3398
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0163	0.0165
Giardia lamblia	Kinase, AGC PKA	0.0131	0.1955	0.2427
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0059	0.0664	0.0712
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0059	0.0664	0.0783
Entamoeba histolytica	protein kinase, putative	0.0039	0.0295	0.0298
Echinococcus granulosus	cytohesin 1	0.0032	0.0163	0.0163
Schistosoma mansoni	serine/threonine protein kinase	0.0233	0.3815	0.5817
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0032	0.0163	0.0165
Schistosoma mansoni	serine/threonine protein kinase	0.0192	0.307	0.4682
Echinococcus granulosus	twitchin	0.0023	0.0009	0.0009
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0163	0.0165
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0131	0.1955	1
Brugia malayi	Oxysterol-binding protein	0.0032	0.0163	0.0165
Echinococcus granulosus	mitogen activated protein kinase	0.0059	0.0664	0.0664
Echinococcus multilocularis	insulin receptor	0.0053	0.0542	0.0826
Leishmania major	protein kinase A catalytic subunit	0.0131	0.1955	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0233	0.3815	0.3815
Brugia malayi	PH domain containing protein	0.0032	0.0163	0.0165
Trichomonas vaginalis	AGC family protein kinase	0.057	0.9909	1
Brugia malayi	intracellular kinase	0.0106	0.1501	0.1515
Entamoeba histolytica	p21-activated kinase	0.0039	0.0295	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0163	0.0165
Brugia malayi	Pleckstrin Homology Domain	0.0046	0.0418	0.0422
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0106	0.1501	0.1515
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0039	0.0295	0.0298
Brugia malayi	Dynamin	0.0032	0.0163	0.0165
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0039	0.0295	0.1508
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Brugia malayi	PH domain containing protein	0.0032	0.0163	0.0165
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase subunit type II alpha	0.0114	0.1655	0.167
Schistosoma mansoni	serine/threonine protein kinase	0.0131	0.1955	0.2981
Echinococcus multilocularis	rac serine:threonine kinase	0.0385	0.6558	1
Toxoplasma gondii	AGC kinase	0.0131	0.1955	0.2095
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0039	0.0295	0.0298
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0039	0.0295	0.0493
Trichomonas vaginalis	alpha chimerin, putative	0.0032	0.0163	0.0165
Toxoplasma gondii	AGC kinase	0.0131	0.1955	0.2095
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0131	0.1955	0.2981
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0032	0.0163	0.0249
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0053	0.0542	0.0542
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0163	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0163	0.0165
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0039	0.0295	0.0206
Schistosoma mansoni	tyrosine kinase	0.0053	0.0542	0.0826
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0039	0.0295	0.0316
Schistosoma mansoni	growth factor receptor-bound protein	0.0032	0.0163	0.0249
Echinococcus granulosus	oxysterol binding protein 1	0.0032	0.0163	0.0163
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0131	0.1955	0.2095
Echinococcus multilocularis	Oxysterol binding protein 11	0.0032	0.0163	0.0249
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.0123	0.1824	0.2781
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0353	0.5982	0.9122
Echinococcus multilocularis	Pleckstrin y	0.0032	0.0163	0.0249
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0039	0.0295	0.0298
Echinococcus granulosus	Pleckstrin y	0.0032	0.0163	0.0163
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Schistosoma mansoni	serine/threonine protein kinase	0.0248	0.4087	0.6232
Trichomonas vaginalis	AGC family protein kinase	0.057	0.9909	1
Brugia malayi	Protein kinase domain containing protein	0.0192	0.307	0.3099
Leishmania major	protein kinase, putative	0.0039	0.0295	0.1508
Loa Loa (eye worm)	PH domain-containing protein	0.0032	0.0163	0.0165
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0039	0.0295	0.0298
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0032	0.0163	0.0273
Loa Loa (eye worm)	oxysterol binding protein	0.0032	0.0163	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0418	0.0422
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Brugia malayi	Plekhf2 protein	0.0032	0.0163	0.0165
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0185	0.2939	0.2966
Echinococcus multilocularis	oxysterol binding protein 1	0.0032	0.0163	0.0249
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0163	0.0165
Echinococcus multilocularis	epidermal growth factor receptor	0.0158	0.2442	0.3723
Entamoeba histolytica	PH domain containing protein	0.0032	0.0163	0.0165
Entamoeba histolytica	hypothetical protein	0.0032	0.0163	0.0165
Plasmodium vivax	hypothetical protein, conserved	0.0032	0.0163	0.0273
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0032	0.0163	0.0165
Echinococcus granulosus	myotubularin protein 13	0.0046	0.0418	0.0418
Trichomonas vaginalis	AGC family protein kinase	0.057	0.9909	1
Echinococcus granulosus	Pleckstrin y	0.0032	0.0163	0.0163
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0346	0.5851	0.5851
Echinococcus multilocularis	protein kinase c iota type	0.0206	0.3325	0.507
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0163	0.0165
Trichomonas vaginalis	hypothetical protein	0.0032	0.0163	0.0165
Brugia malayi	hypothetical protein	0.0032	0.0163	0.0165
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Echinococcus multilocularis	nervana 2	0.0346	0.5851	0.8922
Brugia malayi	probable spectrin beta chain	0.0032	0.0163	0.0165
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0032	0.0163	0.0165
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0233	0.3815	0.5817
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0039	0.0295	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0163	0.0165
Leishmania major	hypothetical protein, conserved	0.0032	0.0163	0.0836
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0192	0.307	0.4682
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0039	0.0295	0.0298
Entamoeba histolytica	hypothetical protein	0.0032	0.0163	0.0165
Trichomonas vaginalis	AGC family protein kinase	0.057	0.9909	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0353	0.5982	0.5982
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0032	0.0163	0.0249
Entamoeba histolytica	hypothetical protein, conserved	0.0032	0.0163	0.0165
Schistosoma mansoni	serine/threonine protein kinase	0.0248	0.4087	0.6232
Echinococcus multilocularis	Pleckstrin y	0.0032	0.0163	0.0249
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0192	0.307	0.4682
Trichomonas vaginalis	CMGC family protein kinase	0.0106	0.1501	0.1515
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0162	0.2531	0.2554
Schistosoma mansoni	serine/threonine protein kinase	0.0131	0.1955	0.2981
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0131	0.1955	0.1973
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0192	0.307	0.4682
Entamoeba histolytica	hypothetical protein	0.0032	0.0163	0.0165
Echinococcus granulosus	pleckstrin y domain containing family A	0.0032	0.0163	0.0163
Entamoeba histolytica	PH domain containing protein	0.0032	0.0163	0.0165
Brugia malayi	Oxysterol binding protein	0.0032	0.0163	0.0165
Brugia malayi	TBC domain containing protein	0.0032	0.0163	0.0165
Echinococcus multilocularis	Pleckstrin y	0.0032	0.0163	0.0249
Brugia malayi	PH domain containing protein	0.0032	0.0163	0.0165
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0032	0.0163	0.0165
Brugia malayi	Cadps2 protein	0.0032	0.0163	0.0165
Schistosoma mansoni	hypothetical protein	0.0032	0.0163	0.0249
Schistosoma mansoni	tyrosine kinase	0.0158	0.2442	0.3723
Echinococcus multilocularis	myotubularin protein 13	0.0046	0.0418	0.0637
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0192	0.307	0.307
Echinococcus multilocularis	mitogen activated protein kinase	0.0059	0.0664	0.1013
Echinococcus multilocularis		0.0048	0.0452	0.0689
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0032	0.0163	0.0165
Loa Loa (eye worm)	raf kinase	0.0229	0.3737	0.3771
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0032	0.0163	0.0249
Trichomonas vaginalis	AGC family protein kinase	0.057	0.9909	1
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0032	0.0163	0.0249
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0163	0.0165
Schistosoma mansoni	serine/threonine kinase	0.0192	0.307	0.4682
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0032	0.0163	0.0165
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0032	0.0163	0.0249
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0059	0.0664	0.1013
Entamoeba histolytica	hypothetical protein	0.0039	0.0295	0.0298
Plasmodium vivax	PH domain containing protein	0.0032	0.0163	0.0273
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0163	0.0165
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0664	0.067
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0538	0.9333	0.9419
Schistosoma mansoni	myotubularin-related protein	0.0032	0.0163	0.0249
Trypanosoma brucei	rac serine-threonine kinase, putative	0.057	0.9909	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0163	0.0165
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0039	0.0295	0.1508
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0162	0.2531	0.2554
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0032	0.0163	0.0273
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0163	0.0165
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0032	0.0163	0.0249
Brugia malayi	p70 ribosomal S6 kinase beta	0.0538	0.9333	0.9419
Echinococcus granulosus	DCC interacting protein 13 beta	0.0032	0.0163	0.0163
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0114	0.1655	0.167
Echinococcus multilocularis	serine threonine protein kinase	0.0234	0.3832	0.5844
Entamoeba histolytica	protein kinase, putative	0.0039	0.0295	0.0298
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0137	0.2067	0.2067
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0131	0.1955	0.2802
Trypanosoma cruzi	Protein kinase B	0.0385	0.6558	1
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0131	0.1955	0.1955
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0032	0.0163	0.0249
Trypanosoma cruzi	NIMA-related kinase, putative	0.0039	0.0295	0.0206
Echinococcus multilocularis	protein kinase c epsilon type	0.0208	0.3349	0.5106
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0208	0.3349	0.3379
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0581	0.0586
Loa Loa (eye worm)	uncoordinated protein 104	0.0032	0.0163	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0163	0.0165
Echinococcus multilocularis	epidermal growth factor receptor	0.0086	0.115	0.1753
Echinococcus granulosus	NDR protein kinase	0.0192	0.307	0.307
Schistosoma mansoni	goodpasture antigen-binding protein	0.0032	0.0163	0.0249
Schistosoma mansoni	hypothetical protein	0.0032	0.0163	0.0249
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0131	0.1955	0.1955
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0131	0.1955	0.3268
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0032	0.0163	0.0165
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0131	0.1955	0.2981
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0106	0.1501	0.2092
Toxoplasma gondii	AGC kinase	0.0538	0.9333	1
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0041	0.0326	0.0497
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Schistosoma mansoni	serine/threonine protein kinase	0.0192	0.307	0.4682
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0106	0.1501	0.1515
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0106	0.1501	0.2289
Brugia malayi	Dynamin	0.0032	0.0163	0.0165
Entamoeba histolytica	hypothetical protein	0.0032	0.0163	0.0165
Echinococcus granulosus	serine:threonine protein kinase N2	0.0192	0.307	0.307
Echinococcus granulosus	pdz domain containing protein	0.0032	0.0163	0.0163
Echinococcus granulosus	serine threonine protein kinase nrc	0.0353	0.5982	0.5982
Echinococcus multilocularis	pdz domain containing protein	0.0032	0.0163	0.0249
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0163	0.0165
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0192	0.307	0.3099
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0353	0.5982	0.91
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Brugia malayi	Variant SH3 domain containing protein	0.0033	0.0187	0.0189
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0032	0.0163	0.0165
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0163	0.0165
Echinococcus granulosus	Oxysterol binding protein 11	0.0032	0.0163	0.0163
Brugia malayi	Variant SH3 domain containing protein	0.0032	0.0163	0.0165
Trichomonas vaginalis	AGC family protein kinase	0.0224	0.3646	0.368
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0106	0.1501	0.1501
Echinococcus granulosus	protein kinase c epsilon type	0.0208	0.3349	0.3349
Schistosoma mansoni	syntrophin	0.0032	0.0163	0.0249
Echinococcus granulosus	beta 1 syntrophin	0.0032	0.0163	0.0163
Echinococcus granulosus	protein kinase C gamma type	0.0234	0.3832	0.3832
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0163	0.0165
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Trichomonas vaginalis	CMGC family protein kinase	0.0106	0.1501	0.1515
Entamoeba histolytica	protein kinase 2, putative	0.0353	0.5982	0.6037
Toxoplasma gondii	hypothetical protein	0.0032	0.0163	0.0175
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0106	0.1501	0.1608
Echinococcus granulosus	RNA directed DNA polymerase	0.0041	0.0326	0.0326
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0163	0.0165
Echinococcus granulosus	Pleckstrin y	0.0032	0.0163	0.0163
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0032	0.0163	0.0273
Trypanosoma brucei	protein kinase, putative	0.0106	0.1501	0.1515
Brugia malayi	Protein kinase domain containing protein	0.0192	0.307	0.3099
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0106	0.1501	0.7678
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0039	0.0295	0.0206
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0032	0.0163	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0163	0.0165
Schistosoma mansoni	serine/threonine protein kinase	0.0192	0.307	0.4682
Echinococcus granulosus	insulin receptor	0.0053	0.0542	0.0542
Entamoeba histolytica	hypothetical protein	0.0039	0.0295	0.0298
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0039	0.0295	0.0298
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0032	0.0163	0.0163
Trichomonas vaginalis	centaurin gamma, putative	0.0032	0.0163	0.0165
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0039	0.0295	0.0206
Entamoeba histolytica	protein kinase, putative	0.057	0.9909	1
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0032	0.0163	0.0249
Toxoplasma gondii	AtPH1 family protein	0.0032	0.0163	0.0175
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0032	0.0163	0.0273
Trichomonas vaginalis	AGC family protein kinase	0.057	0.9909	1
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0131	0.1955	0.1973
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0032	0.0163	0.0165
Echinococcus multilocularis	beta 1 syntrophin	0.0032	0.0163	0.0249
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.013	0.1945	0.1963
Schistosoma mansoni	rho gtpase activating protein	0.0032	0.0163	0.0249
Loa Loa (eye worm)	AGC/AKT protein kinase	0.057	0.9909	1
Brugia malayi	Cytohesin 3	0.0032	0.0163	0.0165
Trichomonas vaginalis	protein transport protein sec7, putative	0.0032	0.0163	0.0165
Entamoeba histolytica	protein kinase, putative	0.0106	0.1501	0.1515
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0163	0.0165
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0032	0.0163	0.0163
Echinococcus granulosus	protein kinase c iota type	0.0206	0.3325	0.3325
Echinococcus granulosus	oxysterol binding protein 3	0.0032	0.0163	0.0163
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0032	0.0163	0.0249
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0131	0.1955	0.2802
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0032	0.0163	0.0165
Echinococcus granulosus	nervana 2	0.0346	0.5851	0.5851
Trichomonas vaginalis	protein transport protein sec7, putative	0.0032	0.0163	0.0165
Schistosoma mansoni	vav2	0.0046	0.0418	0.0637
Echinococcus granulosus	dynamin 1	0.0032	0.0163	0.0163
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0353	0.5982	1
Giardia lamblia	Kinase, CMGC GSK	0.0106	0.1501	0.1573
Echinococcus granulosus	mitogen activated protein kinase 3	0.0059	0.0664	0.0664
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0192	0.307	0.4682
Echinococcus granulosus	Rho GTPase activating protein 24	0.0032	0.0163	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0418	0.0422
Echinococcus granulosus	serine/threonine protein kinase	0.0385	0.6558	0.6558
Schistosoma mansoni	serine/threonine protein kinase	0.0131	0.1955	0.2981
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0131	0.1955	0.2981
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0163	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0163	0.0165
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0385	0.6558	0.6618
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0137	0.2067	0.3152
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Brugia malayi	PH domain containing protein	0.0032	0.0163	0.0165
Schistosoma mansoni	oxysterol-binding protein 1	0.0032	0.0163	0.0249
Schistosoma mansoni	atypical protein kinase C	0.0206	0.3325	0.507
Echinococcus multilocularis	cytohesin 1	0.0032	0.0163	0.0249
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0163	0.0165
Echinococcus multilocularis	nervana 2	0.0346	0.5851	0.8922
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0032	0.0163	0.0249
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0032	0.0163	0.0249
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0032	0.0163	0.0165
Leishmania major	hypothetical protein, conserved	0.0032	0.0163	0.0836
Schistosoma mansoni	hypothetical protein	0.0032	0.0163	0.0249
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0059	0.0664	0.3398
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0106	0.1501	0.2289
Schistosoma mansoni	oxysterol-binding protein 1	0.0032	0.0163	0.0249
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Toxoplasma gondii	Oxysterol-binding protein	0.0032	0.0163	0.0175
Entamoeba histolytica	protein kinase, putative	0.057	0.9909	1
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0163	0.0165
Echinococcus multilocularis	actin binding protein anillin	0.0032	0.0163	0.0249
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0192	0.307	0.4682
Brugia malayi	MAP kinase sur-1	0.0059	0.0664	0.067
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0163	0.0165
Brugia malayi	PH domain containing protein	0.0032	0.0163	0.0165
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0039	0.0295	0.0298
Trichomonas vaginalis	AGC family protein kinase	0.0131	0.1955	0.1973
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0039	0.0295	0.0493
Entamoeba histolytica	hypothetical protein	0.0032	0.0163	0.0165
Loa Loa (eye worm)	TK/INSR protein kinase	0.0053	0.0542	0.0547
Brugia malayi	PH domain containing protein	0.0032	0.0163	0.0165
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0032	0.0163	0.0165
Trypanosoma cruzi	NIMA-related kinase, putative	0.0039	0.0295	0.0206
Schistosoma mansoni	tyrosine kinase	0.0086	0.115	0.1753
Echinococcus granulosus	epidermal growth factor receptor	0.0086	0.115	0.115
Schistosoma mansoni	dynamin	0.0032	0.0163	0.0249
Trichomonas vaginalis	centaurin/arf, putative	0.0032	0.0163	0.0165
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0032	0.0163	0.0165
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0353	0.5982	1
Plasmodium falciparum	glycogen synthase kinase 3	0.0106	0.1501	0.2509
Entamoeba histolytica	protein kinase, putative	0.0538	0.9333	0.9419
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0032	0.0163	0.0165
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Echinococcus multilocularis	dynamin 1	0.0032	0.0163	0.0249
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0032	0.0163	0.0165
Onchocerca volvulus		0.0046	0.0418	0.1903
Schistosoma mansoni	protein kinase	0.0137	0.2067	0.3152
Schistosoma mansoni	serine/threonine protein kinase	0.0192	0.307	0.4682
Schistosoma mansoni	serine/threonine protein kinase	0.0208	0.3349	0.5106
Onchocerca volvulus		0.0106	0.1501	1
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0032	0.0163	0.0165
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0032	0.0163	0.0273
Plasmodium falciparum	oxysterol-binding protein, putative	0.0032	0.0163	0.0273
Loa Loa (eye worm)	Plekhf2 protein	0.0032	0.0163	0.0165
Schistosoma mansoni	hypothetical protein	0.0032	0.0163	0.0249
Schistosoma mansoni	tyrosine kinase	0.0082	0.1072	0.1635
Brugia malayi	PH domain containing protein	0.0032	0.0163	0.0165
Echinococcus granulosus	GRB2 associated binding protein 3	0.0032	0.0163	0.0163
Schistosoma mansoni	zinc finger protein	0.0032	0.0163	0.0249
Giardia lamblia	Kinase, AGC PKA	0.0353	0.5982	1
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0032	0.0163	0.0273
Schistosoma mansoni	tyrosine kinase	0.0082	0.1072	0.1635
Schistosoma mansoni	tyrosine kinase	0.0082	0.1072	0.1635
Brugia malayi	PH domain containing protein	0.0032	0.0163	0.0165
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0163	0.0165
Echinococcus multilocularis	protein kinase shaggy	0.0106	0.1501	0.2289
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0032	0.0163	0.0165
Trichomonas vaginalis	centaurin beta, putative	0.0032	0.0163	0.0165
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0131	0.1955	0.1973
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0032	0.0163	0.0165
Entamoeba histolytica	protein kinase domain containing protein	0.0106	0.1501	0.1515
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0032	0.0163	0.0249
Brugia malayi	Furin-like cysteine rich region family protein	0.0158	0.2442	0.2464
Schistosoma mansoni	tyrosine kinase	0.0053	0.0542	0.0826
Echinococcus multilocularis	oxysterol binding protein 9	0.0032	0.0163	0.0249
Schistosoma mansoni	protein kinase	0.0137	0.2067	0.3152
Trichomonas vaginalis	AGC family protein kinase	0.0192	0.307	0.3099
Echinococcus granulosus	nervana 2	0.0346	0.5851	0.5851
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1955	0.1973
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0039	0.0295	0.0206
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0032	0.0163	0.0249
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0131	0.1955	0.1973
Schistosoma mansoni	serine/threonine-protein kinase	0.0385	0.6558	1
Trichomonas vaginalis	AGC family protein kinase	0.0192	0.307	0.3099
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0032	0.0163	0.0165
Trichomonas vaginalis	centaurin alpha, putative	0.0032	0.0163	0.0165
Brugia malayi	PH domain containing protein	0.0032	0.0163	0.0165
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0033	0.0187	0.0189
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0131	0.1955	1
Brugia malayi	protein kinase C II.	0.0208	0.3349	0.3379
Schistosoma mansoni	zinc finger protein	0.0032	0.0163	0.0249
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0346	0.5851	0.8922
Brugia malayi	Protein kinase domain containing protein	0.057	0.9909	1
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0192	0.307	0.3099
Schistosoma mansoni	goodpasture antigen-binding protein	0.0032	0.0163	0.0249
Trichomonas vaginalis	AGC family protein kinase	0.0192	0.307	0.3099
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0163	0.0165
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0131	0.1955	0.1973
Echinococcus granulosus	oxysterol binding protein 9	0.0032	0.0163	0.0163
Brugia malayi	Raf kinase	0.0219	0.356	0.3593
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0163	0.0165
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0192	0.307	0.4682
Echinococcus granulosus	protein kinase shaggy	0.0106	0.1501	0.1501
Toxoplasma gondii	protein kinase domain-containing protein	0.0039	0.0295	0.0316
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0032	0.0163	0.0165
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0664	0.067
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0192	0.307	0.3099
Echinococcus granulosus	Protein kinase C brain isozyme	0.0248	0.4087	0.4087
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0192	0.307	0.3099
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0032	0.0163	0.0249
Entamoeba histolytica	protein kinase, putative	0.0024	0.0024	0.0024
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0039	0.0295	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0163	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0163	0.0165
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0131	0.1955	0.2802
Plasmodium falciparum	PH domain-containing protein, putative	0.0032	0.0163	0.0273
Brugia malayi	Syntrophin-1	0.0032	0.0163	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0163	0.0165
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0053	0.0542	0.0826
Schistosoma mansoni	centaurin alpha	0.0032	0.0163	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0163	0.0165
Leishmania major	folate/biopterin transporter, putative	0.0039	0.0295	0.1508
Schistosoma mansoni	hypothetical protein	0.0032	0.0163	0.0249
Leishmania major	serine/threonine-protein kinase a, putative	0.0039	0.0295	0.1508
Entamoeba histolytica	protein kinase domain containing protein	0.0106	0.1501	0.1515
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0059	0.0664	0.067
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0059	0.0664	0.0783
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0163	0.0165
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0163	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0192	0.307	0.3099
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0664	0.067
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Schistosoma mansoni	dynamin	0.0032	0.0163	0.0249
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0032	0.0163	0.0165
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0032	0.0163	0.0165
Brugia malayi	MAX-1A	0.0032	0.0163	0.0165
Schistosoma mansoni	tyrosine kinase	0.0086	0.115	0.1753
Entamoeba histolytica	protein kinase, putative	0.0039	0.0295	0.0298
Entamoeba histolytica	protein kinase, putative	0.0039	0.0295	0.0298
Trichomonas vaginalis	kinesin light chain, putative	0.0032	0.0163	0.0165
Brugia malayi	Protein kinase domain containing protein	0.0053	0.0542	0.0547
Loa Loa (eye worm)	rho-GTPase-activating	0.0032	0.0163	0.0165
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0131	0.1955	0.1973
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0032	0.0163	0.0163
Trypanosoma brucei	protein kinase, putative	0.0059	0.0664	0.067
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0131	0.1955	0.2802
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0295	0.0298
Loa Loa (eye worm)	cytohesin 3	0.0032	0.0163	0.0165
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0032	0.0163	0.0165
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0032	0.0163	0.0249
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0131	0.1955	0.3268

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 51 uM	Displacement of [3H]BTX-B from voltage gated sodium channel in rat cerebral cortex synaptoneurosomes	ChEMBL.	15588087

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 11291300

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 417730