Detailed information for compound 42594

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 340.348 | Formula: C19H17FN2O3
  • H donors: 0 H acceptors: 2 LogP: 3.12 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1c(C)c(C)cc2c1nc(C)n(c2=O)c1ccc(cc1)F
  • InChi: 1S/C19H17FN2O3/c1-10-9-15-17(16(11(10)2)19(24)25-4)21-12(3)22(18(15)23)14-7-5-13(20)6-8-14/h5-9H,1-4H3
  • InChiKey: KWVZLRJCFDJZCX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0022 0.0022
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0503 0.2153 0.4971
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Leishmania major hypothetical protein, conserved 0.0026 0.0057 0.0523
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.013
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.0348
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0009 0.0067
Plasmodium falciparum cysteine repeat modular protein 1 0.0024 0.0046 0.1175
Mycobacterium ulcerans sulfatase 0.0017 0.0017 0.0145
Giardia lamblia Hypothetical protein 0.0017 0.0017 0.1283
Onchocerca volvulus 0.0018 0.0022 0.0048
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0214 0.5011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.006
Toxoplasma gondii kringle domain-containing protein 0.0024 0.0046 0.0422
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0016 0.001 0.0019
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0099 0.0224
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0057 0.129
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0013 0.0013
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0022 0.0046
Brugia malayi PXA domain containing protein 0.0039 0.0111 0.0296
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0111 0.0252
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0425 0.1011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0043
Schistosoma mansoni hypothetical protein 0.0257 0.1071 0.247
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0009 0.0025
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0016 0.0037
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0072 0.0167
Schistosoma mansoni loxhd1 0.002 0.0028 0.006
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0099 0.0264
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0022 0.006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Schistosoma mansoni hypothetical protein 0.0169 0.0686 0.1581
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0099 0.0264
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.012 1
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0014 0.0002 0.0002
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0251 0.1046 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0076
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0042 0.0128 0.0301
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.02 0.1898
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0099 0.0264
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0099 0.0099
Echinococcus granulosus cpg binding protein 0.003 0.0075 0.0075
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0425 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0128 0.0343
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0022 0.0022
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0214 0.5011
Loa Loa (eye worm) DR-78 0.0017 0.0016 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0026
Onchocerca volvulus 0.0016 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.0348
Onchocerca volvulus 0.0029 0.0067 0.0156
Brugia malayi hypothetical protein 0.0039 0.0111 0.0296
Echinococcus granulosus voltage dependent calcium channel subunit 0.104 0.4516 0.4516
Onchocerca volvulus 0.0042 0.0128 0.0301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0026
Echinococcus multilocularis expressed protein 0.0033 0.0088 0.0088
Schistosoma mansoni cpg binding protein 0.0029 0.0067 0.0151
Trichomonas vaginalis set domain proteins, putative 0.0966 0.4191 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0026
Loa Loa (eye worm) cytochrome P450 family protein 0.007 0.025 0.0681
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0043
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.006
Brugia malayi nuclear receptor NHR-88 0.0036 0.0099 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0022 0.006
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0122 0.0479 0.1103
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0081 0.0296 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0111 0.0302
Entamoeba histolytica hypothetical protein 0.0037 0.0106 0.2455
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0035
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0009 0.0067
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0022 0.0054
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0099 0.0099
Onchocerca volvulus 0.0018 0.0022 0.0048
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0099 0.0224
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.1046 1
Brugia malayi hypothetical protein 0.0017 0.0016 0.0037
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0069 0.0183
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.006
Brugia malayi nuclear receptor RXR 0.0019 0.0025 0.0062
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0138 0.0375
Echinococcus multilocularis thyroid hormone receptor alpha 0.0293 0.1229 0.1229
Schistosoma mansoni rotamase 0.0033 0.0088 0.0199
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0117 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0006
Brugia malayi Intermediate filament tail domain containing protein 0.0083 0.0308 0.0834
Echinococcus granulosus tumor protein p63 0.0352 0.1488 0.1488
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0111 0.0296
Echinococcus granulosus lamin dm0 0.0083 0.0308 0.0308
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0111 0.026
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0099 0.0264
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0479 0.1103
Entamoeba histolytica hypothetical protein 0.0037 0.0106 0.2455
Schistosoma mansoni blooms syndrome DNA helicase 0.0027 0.0062 0.0138
Echinococcus granulosus cathepsin l1 0.0016 0.0013 0.0013
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0025 0.0052
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0016 0.0032
Brugia malayi PAN domain containing protein 0.0015 0.0009 0.0019
Echinococcus granulosus pikachurin 0.0024 0.0048 0.0048
Loa Loa (eye worm) glutamate receptor 0.0035 0.0096 0.0261
Entamoeba histolytica hypothetical protein 0.0039 0.0111 0.2571
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0106 0.2455
Brugia malayi PAN domain containing protein 0.0015 0.0009 0.0019
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0022 0.0054
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0106 0.0283
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0099 0.0099
Loa Loa (eye worm) phosphofructokinase 0.011 0.0425 0.1157
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0998 0.4329 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.012 1
Brugia malayi PAN domain containing protein 0.0015 0.0009 0.0019
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0072 0.0167
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.013
Brugia malayi nuclear receptor RXR 0.0017 0.0016 0.0037
Onchocerca volvulus 0.0018 0.0022 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0099 0.0264
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0128 0.0343
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0013 0.0026
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0067
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0088 0.0234
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0057 0.1547
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0013 0.0013
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0015 0.0009 0.0067
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0022 0.0022
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0229 0.0524
Loa Loa (eye worm) hypothetical protein 0.0638 0.2748 0.7478
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0043
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0022 0.0022
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0013 0.0025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0013 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0046 0.1041
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0023 0.0042 0.0114
Mycobacterium tuberculosis Probable sulfatase 0.0017 0.0017 0.0145
Toxoplasma gondii subtilisin SUB12 0.0015 0.0009 0.0067
Loa Loa (eye worm) hypothetical protein 0.0122 0.0479 0.1304
Onchocerca volvulus 0.0016 0.0013 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0479 0.1103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0214 0.5011
Onchocerca volvulus 0.0015 0.0009 0.0017
Echinococcus granulosus expressed protein 0.0033 0.0088 0.0088
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0168 0.0383
Brugia malayi EGF-like domain containing protein 0.0024 0.0048 0.0124
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0028 0.0028
Onchocerca volvulus 0.0016 0.0013 0.0026
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0106 0.0996
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0099 0.0264
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0022 0.0054
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0014
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.0048 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0099 0.027
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.013
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0156 0.0419
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0013 0.0104
Leishmania major cathepsin L-like protease 0.0062 0.0214 0.2033
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0111 0.0296
Loa Loa (eye worm) TK/ROR protein kinase 0.0024 0.0046 0.0125
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0425 0.4057
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0006 0.0104
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0111 0.0111
Brugia malayi Cathepsin L-like precursor 0.0016 0.0013 0.003
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0425 1
Echinococcus multilocularis tumor protein p63 0.0352 0.1488 0.1488
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0106 0.0106
Echinococcus multilocularis expressed protein 0.0751 0.3244 0.3244
Loa Loa (eye worm) hypothetical protein 0.004 0.0118 0.0322
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0013 0.0026
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0106 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0425 0.0978
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0009 0.0067
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0081 0.0296 0.6141
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0043
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.012 0.012
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0111 0.0302
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0022 0.0054
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0425 0.1011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0214 0.5011
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0138 0.037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0099 0.027
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0016 0.0043
Brugia malayi 6-phosphofructokinase 0.011 0.0425 0.1153
Loa Loa (eye worm) hypothetical protein 0.024 0.0994 0.2706
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0017 0.0017 0.0036
Loa Loa (eye worm) hypothetical protein 0.0081 0.0296 0.0805
Brugia malayi hypothetical protein 0.0037 0.0106 0.0283
Loa Loa (eye worm) CUTiclin-Like family member 0.0042 0.0128 0.0348
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0111 0.0252
Brugia malayi hypothetical protein 0.0042 0.0128 0.0343
Onchocerca volvulus 0.0042 0.0128 0.0301
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0022 0.0054
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0025
Brugia malayi Sulfatase family protein 0.0017 0.0017 0.0041
Loa Loa (eye worm) CUTiclin family member 0.0042 0.0128 0.0348
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0028 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0214 0.5011
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0111 0.0111
Entamoeba histolytica elongation factor-2 kinase, putative 0.0042 0.0128 0.2977
Brugia malayi PAN domain containing protein 0.0015 0.0009 0.0019
Schistosoma mansoni survival motor neuron protein 0.0049 0.0156 0.0356
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0425 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Brugia malayi nuclear hormone receptor 0.0017 0.0016 0.0037
Echinococcus multilocularis lamin dm0 0.0083 0.0308 0.0308
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0025 0.0025
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.012 0.2795
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.006
Echinococcus granulosus tissue type plasminogen activator 0.0024 0.0046 0.0046
Echinococcus multilocularis musashi 0.0083 0.0308 0.0308
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0111 0.0111
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0016 0.0033
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0075 0.0271 0.0271
Schistosoma mansoni nuclear receptor 0.0017 0.0016 0.0032
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0111 0.0111
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0022 0.006
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0017 0.0017 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Onchocerca volvulus 0.0083 0.0308 0.0731
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0042 0.0128 0.0343
Brugia malayi laminin alpha chain 0.0024 0.0048 0.0124
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0015 0.0005 0.0008
Onchocerca volvulus 0.0015 0.0009 0.0017
Entamoeba histolytica hypothetical protein 0.0037 0.0106 0.2455
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0072 0.0671
Onchocerca volvulus 0.0051 0.0168 0.0395
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0128 0.0343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0026
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0122 0.0479 0.0479
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.012 0.2795
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0022 0.0022
Echinococcus granulosus collagen alpha 1VII chain 0.0042 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0039 0.0111 0.0302
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0214 0.5011
Leishmania major cathepsin L-like protease 0.0016 0.0013 0.0104
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0425 0.1157
Echinococcus granulosus survival motor neuron protein 1 0.024 0.0994 0.0994
Schistosoma mansoni hypothetical protein 0.0049 0.0156 0.0356
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0425 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0025 0.0067
Plasmodium vivax vivapain-2 0.0016 0.0013 0.0188
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0022 0.0022
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0425 0.0978
Brugia malayi Pre-SET motif family protein 0.0849 0.3675 1
Loa Loa (eye worm) hypothetical protein 0.0461 0.1967 0.5351
Echinococcus multilocularis cysteine protease 0.0016 0.0013 0.0013
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0425 0.0899
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0081 0.0758
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0009 0.0067
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0083 0.0308 0.0839
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.1046 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0247 0.5776
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0099 0.0232
Brugia malayi hypothetical protein 0.0245 0.1018 0.2767
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0111 0.026
Brugia malayi von Willebrand Factor 0.0042 0.0128 0.0343
Plasmodium vivax thrombospondin-related anonymous protein 0.0042 0.0128 0.2612
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0111 0.0111
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0128 0.2977
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0069 0.0643
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0016 0.0016
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0081 0.0296 0.2815
Schistosoma mansoni rab6-interacting 0.002 0.0028 0.006
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0022 0.0022
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0034 0.0077
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.006
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0232 0.0963 0.0963
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0106 0.0248
Echinococcus multilocularis GPCR, family 3, C terminal 0.0015 0.0005 0.0005
Toxoplasma gondii cathepsin CPL 0.0016 0.0013 0.0104
Schistosoma mansoni nuclear receptor 0.0017 0.0016 0.0032
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0425 0.1011
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0069 0.0183
Entamoeba histolytica hypothetical protein 0.0042 0.0128 0.2977
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.006
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0099 0.0224
Schistosoma mansoni zinc finger protein 0.0017 0.0016 0.0032
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.002 0.0028 0.006
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2287 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Onchocerca volvulus 0.0015 0.0009 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0111 0.026
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0099 0.0264
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0214 0.5011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0099 0.0099
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0016 0.0037
Onchocerca volvulus 0.0042 0.0128 0.0301
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0025 0.0052
Giardia lamblia Sgs1 DNA helicase, putative 0.0029 0.0069 0.5669
Schistosoma mansoni thyroid hormone receptor 0.0293 0.1229 0.2835
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0111 0.0111
Giardia lamblia Hypothetical protein 0.0017 0.0017 0.1283
Echinococcus granulosus lamin 0.0083 0.0308 0.0308
Toxoplasma gondii microneme protein, putative 0.0015 0.0009 0.0067
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.012 0.0282
Brugia malayi PAN domain containing protein 0.0015 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0188
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.0348
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0111 0.0252
Brugia malayi hypothetical protein 0.0017 0.0016 0.0037
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0128 0.0343
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0014 0.0002 0.0002
Schistosoma mansoni lipoxygenase 0.002 0.0028 0.006
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0042 0.0128 0.2612
Entamoeba histolytica cysteine protease, putative 0.0016 0.0013 0.0256
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0026
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0081 0.1867
Brugia malayi Cytochrome P450 family protein 0.007 0.025 0.0676
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0022 0.0022
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.005 0.0459
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0022 0.0054
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0022 0.0046
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0257 0.1071 0.1071
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0111 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0118 0.0118
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0016 0.0037
Loa Loa (eye worm) hypothetical protein 0.0023 0.0042 0.0114
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0849 0.3675 1
Onchocerca volvulus 0.0016 0.0013 0.0026
Onchocerca volvulus 0.0042 0.0128 0.0301
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0016 0.0016
Loa Loa (eye worm) ctsf protein 0.0016 0.0013 0.0035
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.0348
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0067
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0128 0.0343
Leishmania major hypothetical protein, conserved 0.0024 0.0046 0.0422
Brugia malayi Kringle domain containing protein 0.0024 0.0046 0.012
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0013 0.0026
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0111 0.0302
Brugia malayi Cathepsin L-like precursor 0.0016 0.0013 0.003
Brugia malayi ecdysone receptor 0.0017 0.0016 0.0037
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0016 0.0016
Echinococcus multilocularis tissue type plasminogen activator 0.0024 0.0046 0.0046
Echinococcus granulosus RUN 0.002 0.0028 0.0028
Schistosoma mansoni cell polarity protein 0.0024 0.0048 0.0105
Brugia malayi PAN domain containing protein 0.0015 0.0009 0.0019
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0022 0.0022
Mycobacterium ulcerans hypothetical protein 0.0021 0.0034 0.0311
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0094
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0009 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0106 0.2455
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0106 0.0248
Loa Loa (eye worm) hypothetical protein 0.0039 0.0112 0.0304
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0111 0.0252
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0099 0.0224
Mycobacterium ulcerans arylsulfatase AtsD 0.0017 0.0017 0.0145
Onchocerca volvulus 0.0015 0.0009 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0099 0.0264
Toxoplasma gondii microneme protein MIC17B 0.0015 0.0009 0.0067
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0028 0.0504
Loa Loa (eye worm) hypothetical protein 0.0036 0.0099 0.027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.0348
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.006
Brugia malayi CXXC zinc finger family protein 0.0029 0.0067 0.0178
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.0069 0.0069
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0251 0.1046 0.1046
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0099 0.0224
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0111 0.0111
Brugia malayi hypothetical protein 0.002 0.0028 0.007
Toxoplasma gondii hypothetical protein 0.0015 0.0009 0.0067
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.0994 0.0994
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0047
Echinococcus multilocularis metabotropic glutamate receptor 5 0.011 0.0425 0.0425
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0425 0.0425
Loa Loa (eye worm) intermediate filament protein 0.0083 0.0308 0.0839
Mycobacterium ulcerans endonuclease IV 0.0081 0.0296 0.2815
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0015 0.0005 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Schistosoma mansoni nAChR subunit 0.0018 0.0022 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.006
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0013 0.0013
Brugia malayi PAN domain containing protein 0.0015 0.0009 0.0019
Brugia malayi PAN domain containing protein 0.0015 0.0009 0.0019
Echinococcus multilocularis pikachurin 0.0024 0.0048 0.0048
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0122 0.0479 0.4572
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0099 0.0099
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0099 0.0099
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0009 0.0067
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0022 0.006
Brugia malayi conserved hypotetical protein 0.0017 0.0016 0.0037
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0099 0.0099
Brugia malayi 6-phosphofructokinase 0.011 0.0425 0.1153
Schistosoma mansoni nAChR subunit 0.0018 0.0022 0.0046
Schistosoma mansoni DNA helicase recq1 0.0029 0.0069 0.0155
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0099 0.0099
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0106 0.8785
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0022 0.0022
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0232 0.0963 0.2221
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1085 0.4712 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.012 0.0251
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0111 0.0111
Brugia malayi PAN domain containing protein 0.0015 0.0009 0.0019
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0099 0.0099
Brugia malayi Protein kinase domain containing protein 0.0024 0.0046 0.012
Entamoeba histolytica hypothetical protein 0.0039 0.0111 0.2571
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0022 0.0022
Brugia malayi Zona pellucida-like domain containing protein 0.0042 0.0128 0.0343
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0106 0.2455
Treponema pallidum 76K protein 0.0042 0.0128 0.0268
Schistosoma mansoni hypothetical protein 0.0537 0.2304 0.532
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0128 0.0343
Leishmania major cathepsin L-like protease 0.0016 0.0013 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0099 0.027
Onchocerca volvulus Putative nachr subunit 0.0018 0.0022 0.0048
Brugia malayi Cation transporter family protein 0.0018 0.0022 0.0054
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.0081 0.0189
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0125
Schistosoma mansoni serine-rich repeat protein 0.0537 0.2304 0.532
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0016 0.0043
Brugia malayi nuclear receptor NHR-67 0.0017 0.0016 0.0037
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.012 0.2795
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.0994 0.2704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0026
Schistosoma mansoni intermediate filament proteins 0.0083 0.0308 0.0708
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0025
Brugia malayi Cache domain containing protein 0.0461 0.1967 0.5348
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.012 0.1134
Schistosoma mansoni DNA helicase recq5 0.0029 0.0069 0.0155
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0111 0.0296
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0111 0.026
Brugia malayi nuclear receptor NHR-88 0.0017 0.0016 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0106 0.0248
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0106 0.024
Schistosoma mansoni blooms syndrome DNA helicase 0.0015 0.0006 0.001
Chlamydia trachomatis endonuclease IV 0.0081 0.0296 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0026
Schistosoma mansoni lamin 0.0083 0.0308 0.0708
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0214 0.5011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.0175
Schistosoma mansoni ap endonuclease 0.0041 0.012 0.0273
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0425 1
Loa Loa (eye worm) fibroinase 0.0016 0.0013 0.0035
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0006
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0017 0.0017 0.0145
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0247 0.5776
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0085 0.0791
Loa Loa (eye worm) doublecortin family protein 0.002 0.0028 0.0076
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0085 0.195
Plasmodium vivax SET domain protein, putative 0.0122 0.0479 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0013 0.0013
Toxoplasma gondii microneme protein MIC17C 0.0015 0.0009 0.0067
Schistosoma mansoni thyroid hormone receptor 0.0293 0.1229 0.2835
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0016 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0016 0.0037
Schistosoma mansoni ap endonuclease 0.0041 0.012 0.0273
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0111 0.0252
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0013 0.0026
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0022 0.0054
Entamoeba histolytica recQ family helicase, putative 0.0032 0.0081 0.1867
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0013 0.0035
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0099 0.0099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0214 0.5011
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0017 0.0017 0.0036
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0118 0.0118
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0014 0.0002 0.0006
Onchocerca volvulus 0.0122 0.0479 0.1139
Brugia malayi follicle stimulating hormone receptor 0.0239 0.0994 0.27
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0111 0.0111
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0081 0.1867
Treponema pallidum ATP-dependent DNA helicase 0.0015 0.0006 0.0009
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0214 0.5011
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.0048 0.0105
Brugia malayi Cathepsin L-like precursor 0.0016 0.0013 0.003
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0085 0.195
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0214 0.5011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.006
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0013 0.0026
Loa Loa (eye worm) aldehyde dehydrogenase 0.0014 0.0002 0.0006
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.012 0.0322
Mycobacterium ulcerans arylsulfatase, AslA 0.0017 0.0017 0.0145
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0042 0.0128 0.2612
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0425 0.4057
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0106 0.024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0022 0.0054
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.006
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.0115 0.3612
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0025
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0099 0.0099
Echinococcus multilocularis slit 2 protein 0.0024 0.0048 0.0048
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0016 0.0032
Onchocerca volvulus 0.002 0.0028 0.0062
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0039 0.0111 0.0302
Loa Loa (eye worm) hypothetical protein 0.0037 0.0106 0.0288
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0042 0.0128 0.4071
Mycobacterium ulcerans arylsulfatase AtsB 0.0017 0.0017 0.0145
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0014 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0088 0.0205
Leishmania major cathepsin L-like protease 0.0016 0.0013 0.0104
Mycobacterium ulcerans hydrolase 0.0017 0.0017 0.0145
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.006
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.081 0.3505 0.3505
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0111 0.0252
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0247 0.5776
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0106 0.0106
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0013 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0099 0.0264
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.0048 0.0105
Echinococcus multilocularis nAChR subunit 0.0018 0.0022 0.0022
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0016 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0214 0.5011
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0111 0.0252
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0025
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0016 0.0016
Toxoplasma gondii hypothetical protein 0.0015 0.0009 0.0067
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0085 0.195
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0004 0.0045
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0028 0.0028
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0072 0.2091
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.0348
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0247 0.2343
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0013 0.0026
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0022 0.0022
Brugia malayi Cathepsin L-like precursor 0.0016 0.0013 0.003
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.0048 0.013
Brugia malayi Cathepsin L-like precursor 0.0016 0.0013 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0076
Echinococcus granulosus intermediate filament protein 0.0083 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.0348
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0022 0.0046
Schistosoma mansoni hypothetical protein 0.0409 0.1739 0.4014
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.012 0.2795
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0022 0.0022
Onchocerca volvulus 0.0017 0.0016 0.0033
Schistosoma mansoni nAChR subunit 0.0018 0.0022 0.0046
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0034 0.0311
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0111 0.0111
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0106 0.2455
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0013 0.0013
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.1046 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0013 0.0026
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0022 0.0054
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0099 0.027
Loa Loa (eye worm) hypothetical protein 0.0039 0.0111 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0214 0.5011
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.0348
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.012 0.3798
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0106 0.0106
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0067
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0028 0.0531
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.012 0.1134
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0081 0.0296 0.6938
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0099 0.0224
Brugia malayi hypothetical protein 0.002 0.0028 0.007
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0128 0.2977
Entamoeba histolytica hypothetical protein 0.0037 0.0106 0.2455
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.0348
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0016 0.0037
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0072 0.2091
Schistosoma mansoni lipoxygenase 0.0055 0.0184 0.042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0016 0.0016
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0043
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0251 0.1046 0.1046
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0009 0.0067
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0099 0.0264
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0022 0.0022
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0014 0.0002 0.0002
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0111 0.0302
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0067
Plasmodium falciparum thrombospondin-related anonymous protein 0.0042 0.0128 0.4071
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0111 0.0296
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0014 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0099 0.027
Toxoplasma gondii microneme protein MIC2 0.0042 0.0128 0.1208
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0014 0.0002 0.0002
Brugia malayi intermediate filament protein 0.0083 0.0308 0.0834
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0017 0.0017 0.0036
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0009 0.0025
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0099 0.0099
Onchocerca volvulus 0.0015 0.0009 0.0017
Schistosoma mansoni nAChR subunit 0.0018 0.0022 0.0046
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0016 0.0016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0099 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0099 0.027
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0111 0.0252
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0022 0.0022
Echinococcus granulosus nAChR subunit 0.0018 0.0022 0.0022
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0106 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Brugia malayi steroid hormone receptor 0.0036 0.0099 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0026
Schistosoma mansoni nAChR subunit 0.0018 0.0022 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0026
Onchocerca volvulus 0.0015 0.0009 0.0017
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0022 0.0022
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0257 0.1071 0.1071
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0022 0.006
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0111 0.0111
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0085 0.195
Leishmania major cathepsin L-like protease 0.0062 0.0214 0.2033
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0034 0.0088
Loa Loa (eye worm) hypothetical protein 0.0051 0.0168 0.0456
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0025 0.0062
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0022 0.0054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0013 0.0026
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0022 0.0054
Schistosoma mansoni metabotropic glutamate receptor 0.0075 0.0271 0.0621
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0099 0.0224
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0111 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Brugia malayi ecdysteroid receptor 0.0036 0.0099 0.0264
Onchocerca volvulus 0.0015 0.0009 0.0017
Loa Loa (eye worm) glutamate receptor 0.0089 0.0334 0.091
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0042 0.0128 0.0348
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0013 0.003
Schistosoma mansoni aldehyde dehydrogenase 0.0251 0.1046 0.2412
Onchocerca volvulus 0.002 0.0028 0.0062
Echinococcus multilocularis lamin 0.0083 0.0308 0.0308
Onchocerca volvulus 0.0042 0.0128 0.0301
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0081 0.0296 0.08
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0043
Echinococcus granulosus metabotropic glutamate receptor 2 0.0075 0.0271 0.0271
Brugia malayi Cation transporter family protein 0.0018 0.0022 0.0054
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0039 0.0111 0.0302
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0072 0.5919
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0251 0.1046 1
Echinococcus granulosus geminin 0.0169 0.0686 0.0686
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0081 0.0297 0.0804
Loa Loa (eye worm) hypothetical protein 0.0036 0.0099 0.027
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0425 0.1157
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0022 0.0022
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0022 0.0054
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0072 0.1654
Brugia malayi PXA domain containing protein 0.0039 0.0111 0.0296
Echinococcus multilocularis geminin 0.0169 0.0686 0.0686
Plasmodium vivax vivapain-2 0.0016 0.0013 0.0188
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.012 0.012
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0028 0.0028
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0111 0.0111
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.0069 0.1987
Brugia malayi phosphofructokinase 0.011 0.0425 0.1153
Loa Loa (eye worm) hypothetical protein 0.0039 0.0111 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0111 0.026
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.0127 0.034
Onchocerca volvulus 0.0017 0.0016 0.0033
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0099 0.0232
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0099 0.0264
Entamoeba histolytica hypothetical protein 0.0039 0.0111 0.2571
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0099 0.027
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0009 0.0025
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0025
Echinococcus multilocularis RUN 0.002 0.0028 0.0028
Leishmania major cathepsin L-like protease 0.0016 0.0013 0.0104
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0014 0.0002 0.0002
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0154
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0043
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0013 0.0025
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0013 0.0256
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0106 0.0106
Trichomonas vaginalis rotamase, putative 0.0033 0.0088 0.0205
Toxoplasma gondii exonuclease III APE 0.0041 0.012 0.1134
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0025 0.0062
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0099 0.0099
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0072 0.0167
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0099 0.0224
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0111 0.0252
Schistosoma mansoni coup transcription factor 0.0036 0.0099 0.0224
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0016 0.0016
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.019 0.4451
Onchocerca volvulus 0.0042 0.0128 0.0301
Loa Loa (eye worm) RecQ helicase 0.0042 0.0127 0.0346
Onchocerca volvulus 0.0015 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.0348
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0072 0.0167
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.012 0.0282
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0099 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0099 0.0264
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0022 0.0046
Brugia malayi Zona pellucida-like domain containing protein 0.0042 0.0128 0.0343
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.0069 0.0069
Schistosoma mansoni cpg binding protein 0.003 0.0075 0.0168
Toxoplasma gondii PAN/Apple domain-containing protein 0.0015 0.0009 0.0067
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0072 0.0671
Toxoplasma gondii microneme protein MIC17A 0.0015 0.0009 0.0067
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0025
Brugia malayi PAN domain containing protein 0.0015 0.0009 0.0019
Brugia malayi hypothetical protein 0.0017 0.0017 0.0041
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0023 0.0042 0.0114
Onchocerca volvulus 0.0016 0.0013 0.0026
Onchocerca volvulus 0.0015 0.0009 0.0017
Schistosoma mansoni metabotropic glutamate receptor 0.0044 0.0133 0.0302
Onchocerca volvulus 0.0024 0.0046 0.0105
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0106 0.024
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0156 0.3631
Echinococcus granulosus dnaJ subfamily B 0.0409 0.1739 0.1739
Onchocerca volvulus 0.0016 0.0013 0.0026
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0072 0.1433
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0085 0.0791
Treponema pallidum hypothetical protein 0.0042 0.0128 0.0268
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0128 0.2612
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0128 0.0343
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.006
Onchocerca volvulus 0.0018 0.0022 0.0048
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.012 0.2449
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0111 0.0296
Echinococcus granulosus metabotropic glutamate receptor 5 0.011 0.0425 0.0425
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0043
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0128 0.0343
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0425 0.0425
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0072 0.0167
Leishmania major cathepsin L-like protease 0.0062 0.0214 0.2033
Loa Loa (eye worm) hypothetical protein 0.0036 0.0099 0.027
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0022 0.0054
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0036 0.0099 0.027
Onchocerca volvulus 0.0018 0.0022 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Trichomonas vaginalis rotamase, putative 0.0033 0.0085 0.0197
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.0348
Brugia malayi hypothetical protein 0.0026 0.0057 0.0149
Brugia malayi metabotropic glutamate receptor type 2 0.0044 0.0133 0.0356
Brugia malayi Metabotropic glutamate receptor precursor. 0.0089 0.0334 0.0905
Brugia malayi Receptor family ligand binding region containing protein 0.0023 0.0042 0.0109
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0099 0.0224
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0057 0.1547
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.1739 0.1739
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0072 0.1433
Onchocerca volvulus 0.0016 0.0013 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0099 0.0264
Loa Loa (eye worm) hypothetical protein 0.0036 0.0099 0.027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0067
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0022 0.0054
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0111 0.0296
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0026
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.0127 0.0298
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.0127 0.0298
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0042 0.0128 0.2612
Brugia malayi hypothetical protein 0.0019 0.0025 0.0062
Brugia malayi Doublecortin family protein 0.002 0.0028 0.007
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.006
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0099 0.0224
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0006 0.0104
Onchocerca volvulus Poor gastrulation protein homolog 0.0015 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0099 0.027
Echinococcus granulosus bloom syndrome protein 0.0042 0.0127 0.0127
Onchocerca volvulus 0.0015 0.0009 0.0017
Toxoplasma gondii endonuclease IV APN 0.0081 0.0296 0.2815
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.0048 0.0048
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0247 0.0666
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0009 0.0025
Echinococcus granulosus leukotriene A 4 hydrolase 0.0232 0.0963 0.0963
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0042 0.0128 0.4071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0214 0.5011
Brugia malayi hypothetical protein 0.0019 0.0025 0.0062
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.006
Schistosoma mansoni hypothetical protein 0.0042 0.0128 0.0291
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0128 0.0343
Brugia malayi hypothetical protein 0.0017 0.0016 0.0037
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0247 0.0247
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0069 0.0643
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0022 0.0022
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.012 0.0327
Onchocerca volvulus 0.0083 0.0308 0.0731
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0025 0.0052 0.1019
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.012 0.1134
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0247 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0013 0.0256
Brugia malayi tailless protein 0.0017 0.0016 0.0037
Schistosoma mansoni hypothetical protein 0.0015 0.0005 0.0007
Entamoeba histolytica recQ family DNA helicase 0.0015 0.0006 0.0104
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0111 0.0252
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0083 0.0308 0.0839
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0022 0.0054
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.0348
Onchocerca volvulus 0.0018 0.0022 0.0048
Brugia malayi hypothetical protein 0.0039 0.0111 0.0296
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0067 0.0184
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0106 0.0106
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0022 0.0046
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.0048 0.0048
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0014 0.0002 0.0006
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0057 0.0523
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0247 0.5776
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0111 0.026
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0006 0.0042
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0088 0.024
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0026
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0118 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0026
Brugia malayi hypothetical protein 0.024 0.0994 0.2702
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0043
Loa Loa (eye worm) hypothetical protein 0.0039 0.0112 0.0304
Schistosoma mansoni hypothetical protein 0.0024 0.0046 0.0102
Loa Loa (eye worm) hypothetical protein 0.011 0.0425 0.1157
Brugia malayi Cation transporter family protein 0.0018 0.0022 0.0054
Schistosoma mansoni hypothetical protein 0.0037 0.0106 0.024
Onchocerca volvulus 0.0042 0.0128 0.0301
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0111 0.0252
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0099 0.027
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0022 0.006
Brugia malayi Cathepsin L-like precursor 0.0016 0.0013 0.003
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0425 0.1011
Brugia malayi hypothetical protein 0.0107 0.0411 0.1114
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0099 0.027
Schistosoma mansoni slit 0.0024 0.0048 0.0105
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0034 0.0311
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0057 0.129
Schistosoma mansoni cpg binding protein 0.003 0.0075 0.0168
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0013 0.0026
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0072 0.0167
Schistosoma mansoni polycystin 1-related 0.002 0.0028 0.006
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0111 0.0252
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0016 0.0032
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0022 0.0054
Schistosoma mansoni aldehyde dehydrogenase 0.0251 0.1046 0.2412
Echinococcus multilocularis voltage dependent calcium channel subunit 0.104 0.4516 0.4516
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.0348
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0122 0.0479 0.0479
Leishmania major cathepsin L-like protease 0.0016 0.0013 0.0104
Echinococcus granulosus transcription factor Dp 1 0.004 0.0118 0.0118
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0232 0.0963 0.2621
Toxoplasma gondii aldehyde dehydrogenase 0.0251 0.1046 1
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0111 0.0302
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0042 0.0128 0.0128
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0111 0.0111
Brugia malayi Pre-SET motif family protein 0.0122 0.0479 0.1299
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0013 0.0026
Echinococcus granulosus expressed protein 0.0751 0.3244 0.3244
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0111 0.0111
Brugia malayi nuclear hormone receptor 0.0036 0.0099 0.0264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0214 0.5011
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.0069 0.0069
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.006
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0057 0.1109
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Echinococcus multilocularis cpg binding protein 0.003 0.0075 0.0075
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0111 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0099 0.0264
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0072 0.0149
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0072 0.0671
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0072 0.0167
Toxoplasma gondii microneme protein MIC4 0.0015 0.0009 0.0067
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0099 0.0232
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0042 0.0128 0.0348
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0102 0.0388 0.0892
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0016 0.0043
Schistosoma mansoni hypothetical protein 0.0042 0.0128 0.0291
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.0348
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.006
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0022 0.0054
Echinococcus multilocularis cysteine protease 0.0016 0.0013 0.0013
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0022 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0013 0.0026
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0039 0.0111 0.026
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0057 0.129
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0425 1
Echinococcus granulosus slit 2 protein 0.0024 0.0048 0.0048
Onchocerca volvulus 0.0049 0.0156 0.0368
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0111 0.0252
Mycobacterium ulcerans arylsulfatase AtsD 0.0017 0.0017 0.0145
Schistosoma mansoni nAChR subunit 0.0018 0.0022 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.006
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0106 0.0106
Onchocerca volvulus 0.0966 0.4191 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.006
Mycobacterium leprae conserved hypothetical protein 0.0021 0.0034 0.0767
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0111 0.0302
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0024 0.0046 0.0887
Loa Loa (eye worm) cysteine protease 0.0016 0.0013 0.0035
Mycobacterium ulcerans epimerase 0.0021 0.0034 0.0311
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0425 0.4057
Echinococcus multilocularis bloom syndrome protein 0.0042 0.0127 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0017 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0099 0.027
Onchocerca volvulus 0.0015 0.0009 0.0017
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.0069 0.0069
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0111 0.0111
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0013 0.0013
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0022 0.0046
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0247 0.0671
Schistosoma mansoni lamin 0.0083 0.0308 0.0708
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0016 0.0037
Loa Loa (eye worm) hypothetical protein 0.0082 0.0302 0.0821
Echinococcus granulosus GPCR family 3 C terminal 0.0015 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0043
Schistosoma mansoni nAChR subunit 0.0018 0.0022 0.0046
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0016 0.0016
Onchocerca volvulus 0.0036 0.0099 0.0232
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0042 0.0128 0.1208
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0022 0.006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0479 0.1103
Schistosoma mansoni hypothetical protein 0.0169 0.0686 0.1581
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0184 0.0184
Mycobacterium tuberculosis Possible hydrolase 0.0017 0.0017 0.0145
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0013 0.0256
Echinococcus granulosus histone lysine methyltransferase setb 0.0122 0.0479 0.0479
Schistosoma mansoni rab6-interacting 0.002 0.0028 0.006
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0022 0.0022
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0022 0.006
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.0069 0.0188
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0247 0.0565
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0016 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0099 0.0264
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.0048 0.0124

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 440 mg kg-1 Anticonvulsant activity in mice using sc Met seizure test. ChEMBL. 6620301
ED50 (functional) = 440 mg kg-1 Anticonvulsant activity in mice using sc Met seizure test. ChEMBL. 6620301
ED50 (functional) = 600 mg kg-1 Anticonvulsant activity in mice using MES seizure test. ChEMBL. 6620301
ED50 (functional) = 600 mg kg-1 Anticonvulsant activity in mice using MES seizure test. ChEMBL. 6620301
TD50 (ADMET) NA 0 mg kg-1 Anticonvulsant activity expressed as toxic dose in rotorod test (0.5 hr) in mice;NA means inactive. ChEMBL. 6620301

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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