Detailed information for compound 433722

Basic information

Technical information
  • TDR Targets ID: 433722
  • Name: ditert-butyl 2-(4-anilinophenyl)iminoimidazol idine-1,3-dicarboxylate
  • MW: 452.546 | Formula: C25H32N4O4
  • H donors: 1 H acceptors: 2 LogP: 5.23 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(C1=Nc1ccc(cc1)Nc1ccccc1)C(=O)OC(C)(C)C)OC(C)(C)C
  • InChi: 1S/C25H32N4O4/c1-24(2,3)32-22(30)28-16-17-29(23(31)33-25(4,5)6)21(28)27-20-14-12-19(13-15-20)26-18-10-8-7-9-11-18/h7-15,26H,16-17H2,1-6H3
  • InChiKey: HJQJQXPVQAFAAO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-anilinophenyl)iminoimidazolidine-1,3-dicarboxylic acid ditert-butyl ester
  • ditert-butyl 2-(4-phenylazanylphenyl)iminoimidazolidine-1,3-dicarboxylate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.019 0.1372 0.2946
Echinococcus multilocularis snurportin 1 0.0335 0.2561 0.3974
Giardia lamblia DNA damage repair protein 0.0049 0.0228 0.1151
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0242 0.0376
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.0854 0.1833
Loa Loa (eye worm) hypothetical protein 0.0022 0.0002 0.0003
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0038 0.0135 0.0209
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0014 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0014 0.0019
Toxoplasma gondii microneme protein MIC4 0.0022 0.0002 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.0801 0.1721
Brugia malayi PAN domain containing protein 0.0022 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0533 0.4176 0.4176
Schistosoma mansoni hypothetical protein 0.0025 0.0027 0.0027
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.012 0.0801 0.3287
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0146 0.0314
Loa Loa (eye worm) hypothetical protein 0.0085 0.0516 0.0723
Loa Loa (eye worm) phosphofructokinase 0.0126 0.0854 0.1196
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0037 0.0124 0.0192
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0031 0.0082 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.019 0.1372 0.2946
Mycobacterium leprae Probable lipase LipE 0.012 0.0801 0.9379
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.0854 0.7617
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0038 0.0135 0.0189
Echinococcus multilocularis Protein lozenge 0.0055 0.0275 0.0426
Loa Loa (eye worm) glutaminase 2 0.0317 0.241 0.3377
Loa Loa (eye worm) hypothetical protein 0.0232 0.1719 0.2409
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0038 0.0137 0.0689
Loa Loa (eye worm) ThiF family protein 0.0031 0.0082 0.0115
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0104 0.0924
Brugia malayi hypothetical protein 0.0036 0.0121 0.0169
Mycobacterium ulcerans hypothetical protein 0.0312 0.2371 0.9835
Echinococcus granulosus zinc finger protein 0.0023 0.0017 0.0026
Brugia malayi hypothetical protein 0.0037 0.0127 0.0178
Echinococcus granulosus SAM and MBT domain containing protein 0.0204 0.1489 0.2311
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0149 0.1041 0.1041
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0146 0.0219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Entamoeba histolytica hypothetical protein 0.0036 0.0121 0.1077
Brugia malayi MH2 domain containing protein 0.0138 0.0955 0.1338
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0811 0.6444 1
Brugia malayi Pre-SET motif family protein 0.0896 0.7137 1
Brugia malayi Bromodomain containing protein 0.009 0.0558 0.0782
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0104 0.0403
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0035 0.0055
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0135 0.0289
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0146 0.5
Loa Loa (eye worm) PAN domain-containing protein 0.0022 0.0002 0.0003
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0104 0.027
Loa Loa (eye worm) hypothetical protein 0.0048 0.0215 0.0302
Loa Loa (eye worm) phosphatidylinositol 3 0.0038 0.0135 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0014 0.0019
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0204 0.1489 0.1489
Trypanosoma brucei hypothetical protein, conserved 0.0049 0.0228 0.0489
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0161 0.1139 0.1139
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0104 0.5
Loa Loa (eye worm) hypothetical protein 0.0204 0.1489 0.2086
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.1121 0.1831
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0242 0.0242
Toxoplasma gondii PAN domain-containing protein 0.0336 0.2568 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.012 0.0801 0.0801
Schistosoma mansoni hypothetical protein 0.0335 0.2561 0.2561
Loa Loa (eye worm) hypothetical protein 0.0022 0.0002 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0129 0.0875 0.0875
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0543 0.4258 0.6607
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0019
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0038 0.0135 0.1201
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0104 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0083 0.0505 0.1085
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0031 0.0082 0.0004
Toxoplasma gondii PAN domain-containing protein 0.0022 0.0002 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0104 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.019 0.1372 0.2946
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0811 0.6444 1
Schistosoma mansoni lozenge 0.0055 0.0275 0.0275
Brugia malayi Calcitonin receptor-like protein seb-1 0.0046 0.0202 0.0283
Toxoplasma gondii microneme protein MIC17C 0.0022 0.0002 0.0009
Brugia malayi phosphofructokinase 0.0126 0.0854 0.1196
Brugia malayi PAN domain containing protein 0.0022 0.0002 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Toxoplasma gondii microneme protein MIC17B 0.0022 0.0002 0.0009
Mycobacterium tuberculosis Probable esterase LipL 0.012 0.0801 0.1303
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0038 0.0135 0.0289
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0037 0.0124 0.0173
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0104 0.5
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0124 0.0836 0.1297
Toxoplasma gondii hypothetical protein 0.0022 0.0002 0.0009
Brugia malayi 6-phosphofructokinase 0.0126 0.0854 0.1196
Onchocerca volvulus 0.0204 0.1489 0.1825
Schistosoma mansoni sex comb on midleg homolog 0.0204 0.1489 0.1489
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0144 0.0999 0.155
Loa Loa (eye worm) phosphatidylinositol 3 0.0038 0.0135 0.0189
Loa Loa (eye worm) hypothetical protein 0.012 0.0801 0.1123
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.0165 0.0203
Echinococcus multilocularis dna polymerase kappa 0.019 0.1372 0.2129
Loa Loa (eye worm) hypothetical protein 0.0239 0.1775 0.2487
Leishmania major ATP-dependent phosphofructokinase 0.0126 0.0854 0.1809
Trypanosoma brucei DNA polymerase kappa, putative 0.019 0.1372 0.2946
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.012 0.0801 0.0801
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0104 0.0127
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0144 0.0999 0.2145
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0293 1
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0048 0.0215 0.6332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.019 0.1372 0.2946
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0543 0.4258 0.6607
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0146 0.0394
Plasmodium falciparum cysteine repeat modular protein 1 0.0054 0.0263 0.8578
Trypanosoma brucei DNA polymerase kappa, putative 0.019 0.1372 0.2946
Toxoplasma gondii PAN domain-containing protein 0.0336 0.2568 1
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.1376 0.2954
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0048 0.0215 0.0334
Echinococcus granulosus histone lysine methyltransferase setb 0.0149 0.1041 0.1615
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0177 0.0274
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0144 0.0999 0.2145
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0046 0.0202 0.0283
Brugia malayi PAN domain containing protein 0.0022 0.0002 0.0003
Loa Loa (eye worm) pip kinase 2 0.0161 0.1139 0.1596
Onchocerca volvulus 0.0054 0.0263 0.032
Mycobacterium tuberculosis Conserved protein 0.012 0.0801 0.1303
Mycobacterium ulcerans DNA polymerase IV 0.019 0.1372 0.5668
Mycobacterium ulcerans hypothetical protein 0.012 0.0801 0.3287
Brugia malayi 6-phosphofructokinase 0.0126 0.0854 0.1196
Schistosoma mansoni DNA polymerase IV / kappa 0.0049 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.012 0.0801 0.1123
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0479 0.1029
Brugia malayi polk-prov protein 0.008 0.0479 0.0671
Echinococcus granulosus dna polymerase eta 0.0239 0.1775 0.2755
Trypanosoma brucei DNA polymerase kappa, putative 0.019 0.1372 0.2946
Brugia malayi ThiF family protein 0.0048 0.0215 0.0302
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.0854 0.0854
Brugia malayi mbt repeat family protein 0.0204 0.1489 0.2086
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0293 0.0628
Mycobacterium leprae conserved hypothetical protein 0.012 0.0801 0.9379
Echinococcus multilocularis 6 phosphofructokinase 0.0126 0.0854 0.1325
Echinococcus granulosus bloom syndrome protein 0.0061 0.0324 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Leishmania major ubiquitin-activating enzyme-like protein 0.0031 0.0082 0.0148
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0159 0.1121 0.157
Trichomonas vaginalis D-aminoacylase, putative 0.012 0.0801 0.0984
Brugia malayi PAN domain containing protein 0.0022 0.0002 0.0003
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0144 0.0999 0.2145
Trypanosoma brucei chrX additional, unordered contigs 0.0049 0.0228 0.0489
Brugia malayi beta-lactamase family protein 0.012 0.0801 0.1123
Schistosoma mansoni bromodomain containing protein 0.0076 0.0444 0.0444
Schistosoma mansoni DNA polymerase eta 0.0239 0.1775 0.1775
Trichomonas vaginalis D-aminoacylase, putative 0.012 0.0801 0.0984
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0049 0.0228 0.0887
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0019
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0159 0.1121 0.1739
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.028 0.2113 0.4536
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0875 0.0875
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Schistosoma mansoni ap endonuclease 0.0039 0.0146 0.0146
Brugia malayi latrophilin 2 splice variant baaae 0.0032 0.0083 0.0116
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0166 0.1183 0.2518
Leishmania major mitochondrial DNA polymerase beta 0.0592 0.4658 1
Echinococcus granulosus geminin 0.0533 0.4176 0.6481
Trypanosoma brucei DNA polymerase kappa, putative 0.019 0.1372 0.2946
Trypanosoma cruzi DNA polymerase kappa, putative 0.019 0.1372 0.2946
Onchocerca volvulus 0.012 0.0801 0.0981
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0242 0.0242
Brugia malayi ImpB/MucB/SamB family protein 0.0159 0.1121 0.157
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0293 1
Leishmania major importin beta-1 subunit, putative 0.0025 0.0034 0.0043
Echinococcus granulosus snurportin 1 0.0335 0.2561 0.3974
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Echinococcus granulosus 6 phosphofructokinase 0.0126 0.0854 0.1325
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0083 0.0505 0.1085
Brugia malayi Bromodomain containing protein 0.0046 0.02 0.028
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0038 0.0135 0.0289
Trichomonas vaginalis set domain proteins, putative 0.102 0.8147 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0035 0.0055
Trichomonas vaginalis DNA polymerase eta, putative 0.019 0.1372 0.1684
Trichomonas vaginalis esterase, putative 0.012 0.0801 0.0984
Loa Loa (eye worm) hypothetical protein 0.0037 0.0124 0.0173
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.0135 0.0524
Loa Loa (eye worm) MBCTL1 0.0232 0.1719 0.2409
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0592 0.4658 1
Trypanosoma brucei unspecified product 0.0109 0.0719 0.1543
Loa Loa (eye worm) TK/ROR protein kinase 0.0054 0.0263 0.0368
Schistosoma mansoni fkbp-rapamycin associated protein 0.0021 0.000000043924 0.000000043924
Brugia malayi glutaminase DH11.1 0.0317 0.241 0.3377
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0046 0.0202 0.0283
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0022 0.0002 0.0009
Schistosoma mansoni importin beta-1 0.0031 0.0082 0.0082
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.0955 0.1338
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0781 0.1677
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0242 0.034
Echinococcus multilocularis bloom syndrome protein 0.0061 0.0324 0.0503
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0024 0.002 0.0043
Echinococcus granulosus beta LACTamase domain containing family member 0.012 0.0801 0.1244
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0038 0.0135 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0242 0.034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0242 0.0376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0146 0.0205
Loa Loa (eye worm) hypothetical protein 0.0022 0.0002 0.0003
Toxoplasma gondii subtilisin SUB12 0.0022 0.0002 0.0009
Toxoplasma gondii hypothetical protein 0.0096 0.0605 0.2356
Brugia malayi PAN domain containing protein 0.0022 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0002 0.0003
Plasmodium falciparum DNA repair protein REV1, putative 0.0049 0.0228 0.692
Mycobacterium tuberculosis Conserved protein 0.012 0.0801 0.1303
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0038 0.0135 0.1201
Loa Loa (eye worm) mbt repeat family protein 0.0204 0.1489 0.2086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Loa Loa (eye worm) hypothetical protein 0.0022 0.0002 0.0003
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0144 0.0999 0.14
Trypanosoma brucei DNA polymerase IV, putative 0.019 0.1372 0.2946
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0159 0.1121 0.1739
Trypanosoma brucei unspecified product 0.0182 0.131 0.2812
Schistosoma mansoni glutaminase 0.0317 0.241 0.241
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0037 0.0124 0.0482
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0146 0.0227
Trypanosoma brucei DNA polymerase eta, putative 0.0239 0.1775 0.3811
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0781 0.1677
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0034 0.0041
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0034 0.0041
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0037 0.0124 0.0192
Trichomonas vaginalis D-aminoacylase, putative 0.012 0.0801 0.0984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0102 0.0654 0.1404
Schistosoma mansoni hypothetical protein 0.0533 0.4176 0.4176
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0083 0.0505 0.1085
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0037 0.0124 0.0173
Loa Loa (eye worm) hypothetical protein 0.0022 0.0002 0.0003
Trypanosoma cruzi DNA damage repair protein, putative 0.0049 0.0228 0.0489
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0242 0.0376
Loa Loa (eye worm) hypothetical protein 0.0057 0.0293 0.041
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0038 0.0135 0.0289
Echinococcus granulosus histone acetyltransferase MYST2 0.0232 0.1719 0.2668
Onchocerca volvulus 0.102 0.8147 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.019 0.1372 0.1684
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0037 0.0124 0.0192
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0034 0.0041
Brugia malayi Pip kinase protein 2 0.0161 0.1139 0.1596
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0144 0.0999 0.8915
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0146 0.3037
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0038 0.0135 0.0209
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0042 0.0165 0.0355
Trypanosoma cruzi DNA damage repair protein, putative 0.0049 0.0228 0.0489
Brugia malayi Protein kinase domain containing protein 0.0054 0.0263 0.0368
Entamoeba histolytica hypothetical protein 0.0025 0.0034 0.03
Entamoeba histolytica deoxycytidyl transferase, putative 0.0159 0.1121 1
Loa Loa (eye worm) hypothetical protein 0.0439 0.3405 0.4771
Trypanosoma cruzi DNA polymerase eta, putative 0.0239 0.1775 0.3811
Toxoplasma gondii LsmAD domain-containing protein 0.0057 0.0293 0.1139
Echinococcus multilocularis geminin 0.0533 0.4176 0.6481
Loa Loa (eye worm) hypothetical protein 0.0032 0.0083 0.0116
Toxoplasma gondii PAN domain-containing protein 0.0022 0.0002 0.0009
Loa Loa (eye worm) RecQ helicase 0.0061 0.0324 0.0454
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0054 0.0263 0.2278
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0335 0.2561 0.3588
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0104 0.027
Echinococcus multilocularis polycomb protein SCMH1 0.0204 0.1489 0.2311
Plasmodium vivax SET domain protein, putative 0.0129 0.0875 1
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0104 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.019 0.1372 0.2946
Leishmania major hypothetical protein, conserved 0.0057 0.0293 0.0601
Onchocerca volvulus 0.0023 0.0014 0.0014
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0854 0.1048
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.012 0.0801 0.1303
Leishmania major hypothetical protein, conserved 0.0197 0.1435 0.3061
Giardia lamblia GTOR 0.0038 0.0135 0.0288
Brugia malayi Kringle domain containing protein 0.0054 0.0263 0.0368
Leishmania major hypothetical protein, conserved 0.0054 0.0263 0.0536
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0126 0.0854 0.139
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0104 0.0127
Toxoplasma gondii ThiF family protein 0.0031 0.0082 0.032
Echinococcus multilocularis dna polymerase eta 0.0239 0.1775 0.2755
Loa Loa (eye worm) hypothetical protein 0.0046 0.02 0.0281
Toxoplasma gondii hypothetical protein 0.0022 0.0002 0.0009
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0126 0.0854 1
Toxoplasma gondii kringle domain-containing protein 0.0054 0.0263 0.1023
Mycobacterium ulcerans 6-phosphofructokinase 0.0126 0.0854 0.3504
Echinococcus multilocularis SAM and MBT domain containing protein 0.0204 0.1489 0.2311
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0031 0.0082 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Schistosoma mansoni hypothetical protein 0.0032 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0051 0.0242 0.0339
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0854 0.1048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Brugia malayi PAN domain containing protein 0.0022 0.0002 0.0003
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0104 0.1018
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0592 0.4658 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Leishmania major DNA polymerase eta, putative 0.013 0.0882 0.187
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0146 0.0285
Brugia malayi RNA, U transporter 1 0.0089 0.0554 0.0777
Leishmania major phosphatidylinositol 3-kinase, putative 0.0038 0.0135 0.0261
Plasmodium vivax DNA repair protein REV1, putative 0.0049 0.0228 0.1838
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Toxoplasma gondii PAN domain-containing protein 0.0022 0.0002 0.0009
Entamoeba histolytica hypothetical protein 0.0036 0.0121 0.1077
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0854 0.1048
Loa Loa (eye worm) hypothetical protein 0.012 0.0801 0.1123
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0056 0.0283 0.9532
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0146 0.0807
Loa Loa (eye worm) hypothetical protein 0.0046 0.0202 0.0283
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0135 0.0261
Leishmania major DNA polymerase eta, putative 0.0239 0.1775 0.3793
Schistosoma mansoni ap endonuclease 0.0039 0.0146 0.0146
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0048 0.0215 0.0215
Trypanosoma brucei PAB1-binding protein , putative 0.0057 0.0293 0.0628
Onchocerca volvulus 0.0439 0.3405 0.4177
Toxoplasma gondii microneme protein, putative 0.0022 0.0002 0.0009
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0159 0.1121 0.1121
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.012 0.0801 0.1123
Echinococcus granulosus importin subunit beta 1 0.0031 0.0082 0.0127
Mycobacterium tuberculosis Conserved protein 0.012 0.0801 0.1303
Onchocerca volvulus 0.0129 0.0875 0.1071
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0146 0.0227
Schistosoma mansoni DNA helicase recq1 0.0037 0.0124 0.0124
Brugia malayi beta-lactamase 0.012 0.0801 0.1123
Brugia malayi Bloom's syndrome protein homolog 0.0061 0.0324 0.0454
Plasmodium vivax ubiquitin activating enzyme, putative 0.0048 0.0215 0.1682
Mycobacterium ulcerans glutaminase 0.0317 0.241 1
Schistosoma mansoni DNA helicase recq5 0.0037 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0031 0.0082 0.0115
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.0854 0.1833
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.0854 0.7617
Mycobacterium ulcerans lipase LipD 0.012 0.0801 0.3287
Toxoplasma gondii exonuclease III APE 0.0039 0.0146 0.0569
Loa Loa (eye worm) hypothetical protein 0.0054 0.0263 0.0368
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0038 0.0135 0.0209
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0149 0.1041 0.1615
Loa Loa (eye worm) hypothetical protein 0.012 0.0801 0.1123
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0146 0.0552
Loa Loa (eye worm) hypothetical protein 0.012 0.0801 0.1123
Giardia lamblia DINP protein human, muc B family 0.0166 0.1183 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0144 0.0999 0.14
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0037 0.0124 0.0173
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0146 0.0314
Entamoeba histolytica hypothetical protein 0.0036 0.0121 0.1077
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0228 0.0489
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0854 0.1048
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0104 0.1018
Plasmodium vivax hypothetical protein, conserved 0.012 0.0801 0.9077
Trichomonas vaginalis glutaminase, putative 0.0317 0.241 0.2959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0038 0.0135 0.0261
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0135 0.0289
Loa Loa (eye worm) hypothetical protein 0.0043 0.0178 0.025
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0038 0.0135 0.0189
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0037 0.0124 0.1978
Onchocerca volvulus 0.0161 0.1139 0.1396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0038 0.0135 0.0289
Leishmania major DNA damage repair protein, putative 0.0049 0.0228 0.0461
Schistosoma mansoni hypothetical protein 0.0026 0.0035 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.019 0.1372 0.2946
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0479 0.1029
Loa Loa (eye worm) hypothetical protein 0.0049 0.0224 0.0313
Trypanosoma brucei DNA damage repair protein, putative 0.0049 0.0228 0.0489
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0293 0.0628
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0082 0.0127
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0042 0.0165 0.0326
Echinococcus multilocularis histone acetyltransferase MYST2 0.0232 0.1719 0.2668
Echinococcus granulosus dna polymerase kappa 0.019 0.1372 0.2129
Schistosoma mansoni hypothetical protein 0.0054 0.0263 0.0263
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0046 0.0071
Mycobacterium tuberculosis Conserved hypothetical protein 0.0312 0.2371 0.39
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0232 0.1719 0.2668
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0144 0.0999 0.0999
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0038 0.0135 0.0289
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0144 0.0999 0.2122
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.028 0.2113 0.4536
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0161 0.1139 0.1768
Echinococcus multilocularis transcription factor Dp 1 0.0083 0.0505 0.0784
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0149 0.1041 0.1041
Echinococcus multilocularis tissue type plasminogen activator 0.0054 0.0263 0.0408
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0037 0.0131 0.051
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0042 0.0165 0.0355
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0121 0.0121
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.0854 0.7617
Loa Loa (eye worm) beta-lactamase 0.012 0.0801 0.1123
Trichomonas vaginalis DNA helicase recq1, putative 0.0061 0.0324 0.0398
Mycobacterium tuberculosis Probable lipase LipD 0.012 0.0801 0.1303
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0082 0.0176
Brugia malayi hypothetical protein 0.0057 0.0293 0.041
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0104 0.0403
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0146 0.0567
Schistosoma mansoni hypothetical protein 0.0036 0.0121 0.0121
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0046 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Echinococcus multilocularis zinc finger protein 0.0023 0.0017 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Leishmania major DNA polymerase kappa, putative 0.0049 0.0228 0.0461
Trypanosoma cruzi DNA polymerase kappa, putative 0.019 0.1372 0.2946
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.0854 0.0854
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0031 0.0082 0.0176
Trichomonas vaginalis DNA helicase recq, putative 0.0061 0.0324 0.0398
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0409 0.0634
Plasmodium vivax ataxin-2 like protein, putative 0.0057 0.0293 0.2656
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.0801 0.1721
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0146 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0166 0.1183 0.254
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.012 0.0801 0.1123
Loa Loa (eye worm) hypothetical protein 0.0439 0.3405 0.4771
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0038 0.0135 0.0135
Brugia malayi PHD-finger family protein 0.003 0.0069 0.0097
Onchocerca volvulus 0.012 0.0801 0.0981
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0104 0.0127
Loa Loa (eye worm) hypothetical protein 0.0022 0.0002 0.0003
Loa Loa (eye worm) PAN domain-containing protein 0.0022 0.0002 0.0003
Mycobacterium tuberculosis Probable hydrolase 0.012 0.0801 0.1303
Giardia lamblia Sgs1 DNA helicase, putative 0.0037 0.0124 0.0187
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0034 0.0072
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0046 0.0071
Loa Loa (eye worm) hypothetical protein 0.008 0.0479 0.0671
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0031 0.0082 0.0001
Trichomonas vaginalis penicillin-binding protein, putative 0.012 0.0801 0.0984
Mycobacterium ulcerans beta-lactamase 0.012 0.0801 0.3287
Schistosoma mansoni blooms syndrome DNA helicase 0.0042 0.0172 0.0172
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0014 0.0121
Brugia malayi hypothetical protein 0.0439 0.3405 0.4771
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0031 0.0082 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0038 0.0135 0.0289
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0037 0.0124 0.0192
Trypanosoma brucei hypothetical protein, conserved 0.012 0.0801 0.1721
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0104 0.0127
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0014 0.0121
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0161 0.1139 0.1139
Trichomonas vaginalis penicillin-binding protein, putative 0.012 0.0801 0.0984
Loa Loa (eye worm) PAN domain-containing protein 0.0022 0.0002 0.0003
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0038 0.0135 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0161 0.1139 0.1768
Toxoplasma gondii PAN domain-containing protein 0.0022 0.0002 0.0009
Trypanosoma cruzi DNA polymerase eta, putative 0.013 0.0882 0.1894
Loa Loa (eye worm) runx1 0.0055 0.0275 0.0385
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0409 0.0634
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0129 0.0875 0.1357
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.002 0.0024
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0057 0.029 0.113
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.012 0.0801 0.1303
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0232 0.1719 0.2409
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.0854 0.1196
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0781 0.1677
Toxoplasma gondii ABC1 family protein 0.012 0.0801 0.312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0144 0.0999 0.155
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.0955 0.1338
Brugia malayi PAN domain containing protein 0.0022 0.0002 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Brugia malayi beta-lactamase family protein 0.012 0.0801 0.1123
Brugia malayi ImpB/MucB/SamB family protein 0.0239 0.1775 0.2487
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0146 0.1303
Brugia malayi PAN domain containing protein 0.0022 0.0002 0.0003
Mycobacterium ulcerans DNA polymerase IV 0.019 0.1372 0.5668
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0104 0.0403
Echinococcus granulosus tissue type plasminogen activator 0.0054 0.0263 0.0408
Brugia malayi Pre-SET motif family protein 0.0129 0.0875 0.1225
Trypanosoma brucei hypothetical protein, conserved 0.0049 0.0228 0.0489
Schistosoma mansoni zinc finger protein 0.0023 0.0017 0.0017
Toxoplasma gondii microneme protein MIC17A 0.0022 0.0002 0.0009
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0027 0.0038
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0146 0.0314
Mycobacterium ulcerans esterase/lipase LipP 0.012 0.0801 0.3287
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0043 0.018 0.018
Mycobacterium ulcerans hypothetical protein 0.0049 0.0228 0.0893
Schistosoma mansoni terminal deoxycytidyl transferase 0.0159 0.1121 0.1121
Echinococcus granulosus transcription factor Dp 1 0.0083 0.0505 0.0784
Toxoplasma gondii hypothetical protein 0.0048 0.0215 0.0839
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0263 0.0564
Schistosoma mansoni myelin transcription factor 1 myt1 0.0232 0.1719 0.1719
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.028 0.2113 0.452
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0242 0.0242
Schistosoma mansoni sex comb on midleg homolog 0.0204 0.1489 0.1489
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0242 0.0376
Loa Loa (eye worm) glutaminase 0.0317 0.241 0.3377
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0896 0.7137 1
Leishmania major hypothetical protein, conserved 0.012 0.0801 0.1696
Brugia malayi Importin beta-1 subunit 0.0031 0.0082 0.0115
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0014 0.0121
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0027 0.0046 0.01
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0166 0.1183 0.1935
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0121 0.0187
Brugia malayi PAN domain containing protein 0.0022 0.0002 0.0003
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0038 0.0135 0.0209
Trypanosoma brucei DNA polymerase IV, putative 0.019 0.1372 0.2946
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Trypanosoma brucei unspecified product 0.0109 0.0719 0.1543
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0177 0.0274
Mycobacterium tuberculosis Probable conserved lipoprotein 0.012 0.0801 0.1303
Leishmania major DNA polymerase kappa, putative 0.0166 0.1183 0.2518
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0082 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0135 0.0165
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0031 0.0082 0.0128
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0146 0.0179
Brugia malayi ThiF family protein 0.0031 0.0082 0.0115
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0038 0.0135 0.0289
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0082 0.032
Loa Loa (eye worm) PAN domain-containing protein 0.0022 0.0002 0.0003
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0024 0.002 0.0077
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.0854 0.1196
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0592 0.4658 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0121 0.0187
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0146 0.0179
Echinococcus granulosus polycomb protein SCMH1 0.0204 0.1489 0.2311
Brugia malayi PAN domain containing protein 0.0022 0.0002 0.0003
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0083 0.0505 0.1085
Trypanosoma brucei DNA polymerase IV, putative 0.0182 0.131 0.2812
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0037 0.0124 0.0482
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0038 0.0135 0.0289
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0764 0.6058 1
Entamoeba histolytica recQ family helicase, putative 0.0042 0.0165 0.1474
Onchocerca volvulus 0.012 0.0801 0.0981
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0228 0.0489
Toxoplasma gondii PAN/Apple domain-containing protein 0.0022 0.0002 0.0009
Trypanosoma cruzi DNA polymerase kappa, putative 0.019 0.1372 0.2946
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0019
Trypanosoma brucei DNA damage repair protein, putative 0.0049 0.0228 0.0489
Mycobacterium tuberculosis Probable lipase LipE 0.012 0.0801 0.1303
Echinococcus multilocularis beta LACTamase domain containing family member 0.012 0.0801 0.1244
Entamoeba histolytica hypothetical protein 0.0036 0.0121 0.1077
Loa Loa (eye worm) PAN domain-containing protein 0.0022 0.0002 0.0003
Toxoplasma gondii ImpB/MucB/SamB family protein 0.013 0.0882 0.3435
Loa Loa (eye worm) hypothetical protein 0.0024 0.002 0.0028
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0126 0.0854 1
Brugia malayi mbt repeat family protein 0.0204 0.1489 0.2086
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0038 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.012 0.0801 0.1123
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0232 0.1719 0.2668
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0204 0.1489 0.1825
Loa Loa (eye worm) hypothetical protein 0.0149 0.1041 0.1459
Loa Loa (eye worm) hypothetical protein 0.0161 0.1139 0.1596
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.002 0.0024
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0048 0.0215 0.0334
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0129 0.0875 0.3405

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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