Detailed information for compound 44476

Basic information

Technical information
  • TDR Targets ID: 44476
  • Name: 2-cyclohexyl-4,5-diphenyl-1H-imidazole
  • MW: 302.413 | Formula: C21H22N2
  • H donors: 1 H acceptors: 1 LogP: 5.59 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCC(CC1)c1nc(c([nH]1)c1ccccc1)c1ccccc1
  • InChi: 1S/C21H22N2/c1-4-10-16(11-5-1)19-20(17-12-6-2-7-13-17)23-21(22-19)18-14-8-3-9-15-18/h1-2,4-7,10-13,18H,3,8-9,14-15H2,(H,22,23)
  • InChiKey: LDMYJRJLSGLBHW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-cyclohexyl-4,5-di(phenyl)-1H-imidazole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Acyl coenzyme A:cholesterol acyltransferase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus granulosus sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma japonicum ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus multilocularis sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma mansoni sterol O-acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 24.1 %
Dictyostelium discoideum diacylglycerol O-acyltransferase 1 Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 547 aa 22.3 %
Neospora caninum sterol O-acyltransferase, putative Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 21.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0575
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0029 0.0105
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0025 0.1827
Treponema pallidum alginate O-acetylation protein (algI) 0.0026 0.0029 0.1537
Brugia malayi Patched family protein 0.0012 0.0005 0.0007
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0015 0.0049
Loa Loa (eye worm) RNA binding protein 0.0063 0.0093 0.1181
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0009 0.0026
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0015 0.0701
Echinococcus granulosus expressed conserved protein 0.0185 0.03 0.1284
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0108 0.0391
Echinococcus multilocularis muscleblind protein 1 0.0298 0.0493 0.1797
Brugia malayi Patched family protein 0.0012 0.0005 0.0007
Trypanosoma brucei telomerase reverse transcriptase 0.1606 0.2721 1
Onchocerca volvulus 0.0012 0.0005 0.0004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0066 0.201
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0033 0.0041 0.0145
Loa Loa (eye worm) patched family protein 0.0012 0.0005 0.0069
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0034 0.012
Loa Loa (eye worm) patched family protein 0.0012 0.0005 0.0069
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0002 0.0003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0192 1
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0108 0.0453
Schistosoma mansoni hypothetical protein 0.0024 0.0027 0.0106
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0015 0.0516
Brugia malayi DNA polymerase I family protein 0.0033 0.0041 0.0057
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0015 0.0064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Brugia malayi Patched family protein 0.0012 0.0005 0.0007
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0021 0.0072
Echinococcus granulosus tar DNA binding protein 0.0063 0.0093 0.0399
Brugia malayi Patched related family protein 10 0.0012 0.0005 0.0007
Onchocerca volvulus 0.0014 0.0009 0.0007
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0057
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0021 0.0091
Toxoplasma gondii hypothetical protein 0.0026 0.0029 0.01
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0015 0.0516
Brugia malayi Patched family protein 0.0012 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0009 0.0368
Brugia malayi Cytochrome P450 family protein 0.0018 0.0015 0.0021
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0015 0.0516
Plasmodium vivax patched family protein, putative 0.0012 0.0005 0.0013
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0015 0.0701
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Onchocerca volvulus 0.0012 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0009 0.0177
Entamoeba histolytica hypothetical protein 0.0072 0.0108 0.3321
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0026 0.0029 0.0105
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0026 0.0029 0.0105
Toxoplasma gondii helicase, putative 0.0033 0.0041 0.0145
Echinococcus granulosus dnaJ subfamily B 0.0407 0.0679 0.2908
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0015 0.0516
Loa Loa (eye worm) cytochrome P450 0.0018 0.0015 0.0192
Schistosoma mansoni cpg binding protein 0.003 0.0037 0.0149
Loa Loa (eye worm) CYP4Cod1 0.0026 0.003 0.038
Brugia malayi Patched family protein 0.0012 0.0005 0.0007
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0026 0.0029 0.0117
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0015 0.0701
Toxoplasma gondii hypothetical protein 0.0012 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0264 0.0435 0.5504
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0023
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0002 0.0000074443
Leishmania major cytochrome p450-like protein 0.0018 0.0015 0.0023
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0015 0.0516
Onchocerca volvulus 0.0012 0.0005 0.0004
Plasmodium vivax plastid replication-repair enzyme, putative 0.0033 0.0041 0.0145
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0015 0.0701
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0009 0.0026
Brugia malayi Patched family protein 0.0012 0.0005 0.0007
Loa Loa (eye worm) twinkle helicase 0.0024 0.0027 0.0336
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0192 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0009 0.0026
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0021 0.0072
Brugia malayi MBOAT family protein 0.0026 0.0029 0.004
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0093 0.0392
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0009 0.0177
Brugia malayi MBOAT family protein 0.0026 0.0029 0.004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0026 0.0029 0.0105
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0009 0.0368
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0015 0.0701
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0029 0.0117
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0029 0.0117
Trichomonas vaginalis porcupine, putative 0.0026 0.0029 0.2142
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0026 0.0029 0.01
Onchocerca volvulus 0.0012 0.0005 0.0004
Schistosoma mansoni importin beta-1 0.0029 0.0034 0.014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0009 0.0368
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0009 0.0368
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0042 0.1965
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0015 0.0701
Echinococcus multilocularis cpg binding protein 0.003 0.0037 0.0133
Leishmania major mitochondrial DNA polymerase I protein A, putative 0.0033 0.0041 0.0119
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0066 0.3369
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0029 0.0124
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0066 0.021
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0015 0.0516
Brugia malayi Patched family protein 0.0012 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0026 0.0029 0.0368
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0015 0.0023
Leishmania major cytochrome p450-like protein 0.0018 0.0015 0.0023
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.0511 0.6466
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0088 0.0371
Echinococcus multilocularis Niemann Pick C1 protein 0.0197 0.032 0.1166
Leishmania major glycerol uptake protein, putative 0.0026 0.0029 0.0075
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0029 0.01
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0066 0.3369
Toxoplasma gondii patched family protein 0.0012 0.0005 0.0013
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0081 0.0123 0.0445
Schistosoma mansoni microtubule-associated protein tau 0.1378 0.2333 1
Onchocerca volvulus 0.0096 0.0149 0.0147
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0015 0.0701
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0009 0.0177
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0009 0.0012
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0009 0.0026
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0009 0.0368
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0066 0.021
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0009 0.0026
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.162 0.2744 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0015 0.0701
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0021 0.0072
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0002 0.00000040574
Brugia malayi Telomerase reverse transcriptase 0.4274 0.7265 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0029 0.0368
Echinococcus granulosus cpg binding protein 0.003 0.0037 0.0156
Brugia malayi hypothetical protein 0.0012 0.0005 0.0007
Brugia malayi MBOAT family protein 0.0026 0.0029 0.004
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0575
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0026 0.0029 0.01
Onchocerca volvulus 0.0014 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Brugia malayi MBOAT family protein 0.0026 0.0029 0.004
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0066 0.3369
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0015 0.0516
Schistosoma mansoni hypothetical protein 0.0407 0.0679 0.2903
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0575
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0066 0.3237
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0002 0.0000074443
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0015 0.0516
Brugia malayi protein C24B5.3 0.0012 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0298 0.0493 0.6248
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0029 0.0124
Onchocerca volvulus 0.0014 0.0009 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0066 0.0091
Brugia malayi Myosin head containing protein 0.0012 0.0005 0.0007
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0021 0.0271
Loa Loa (eye worm) hypothetical protein 0.0084 0.0129 0.1632
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0002 0.0000074443
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0015 0.0752
Echinococcus multilocularis twinkle protein, mitochondrial 0.0024 0.0027 0.0096
Loa Loa (eye worm) hhat protein 0.0026 0.0029 0.0368
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.003 0.0104
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0015 0.0701
Schistosoma mansoni hypothetical protein 0.0026 0.0029 0.0117
Brugia malayi Niemann-Pick C1 protein precursor 0.0197 0.032 0.0441
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0026 0.0029 0.0117
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0129 0.0552
Echinococcus multilocularis expressed conserved protein 0.0185 0.03 0.1092
Entamoeba histolytica hypothetical protein 0.0072 0.0108 0.3321
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0093 0.0128
Schistosoma mansoni hypothetical protein 0.0096 0.0149 0.0632
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0042 0.1965
Brugia malayi hypothetical protein 0.0072 0.0108 0.0148
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0026 0.0029 0.01
Leishmania major hypothetical protein, conserved 0.0026 0.0029 0.0075
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.003 0.1483
Mycobacterium ulcerans hypothetical protein 0.0047 0.0066 0.3369
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0066 0.3369
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0029 0.0368
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0009 0.0037
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0009 0.0026
Schistosoma mansoni zinc finger protein 0.0026 0.0029 0.0117
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0093 0.0392
Toxoplasma gondii patched family protein 0.0012 0.0005 0.0013
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0002 0.0000029718
Echinococcus multilocularis survival motor neuron protein 1 0.0472 0.079 0.2877
Schistosoma mansoni sterol O-acyltransferase 1 0.0264 0.0435 0.1857
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Plasmodium vivax telomerase reverse transcriptase, putative 0.1606 0.2721 1
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0029 0.0855
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0066 0.3237
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0575
Echinococcus multilocularis protein dispatched 1 0.0096 0.0149 0.0543
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0009 0.0026
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0021 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0066 0.0091
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0015 0.0516
Echinococcus multilocularis 0.0018 0.0015 0.0054
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0029 0.0105
Plasmodium falciparum plastid replication-repair enzyme 0.0033 0.0041 0.0145
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0034 0.012
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0026 0.0029 0.0124
Leishmania major glycerol uptake protein, putative 0.0026 0.0029 0.0075
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0015 0.0701
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0015 0.0701
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0015 0.0516
Schistosoma mansoni DNA polymerase I 0.0033 0.0041 0.0169
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1606 0.2721 1
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0009 0.003
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0009 0.0026
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0192 0.0815
Brugia malayi MBOAT family protein 0.0026 0.0029 0.004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0112
Schistosoma mansoni survival motor neuron protein 0.0096 0.0149 0.0632
Trypanosoma brucei cytochrome P450, putative 0.0026 0.003 0.0104
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0009 0.0031
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0029 0.01
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Brugia malayi RNA, U transporter 1 0.0082 0.0125 0.0172
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0014 0.0009 0.0395
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0015 0.0701
Giardia lamblia Telomerase catalytic subunit 0.1606 0.2721 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0021 0.0072
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0009 0.0177
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0015 0.0516
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0009 0.0177
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0045 0.2462
Echinococcus granulosus muscleblind protein 0.0298 0.0493 0.2114
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Schistosoma mansoni ran 0.0021 0.0021 0.0084
Schistosoma mansoni hypothetical protein 0.0308 0.0511 0.2182
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0042 0.1965
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0026 0.0029 0.0117
Plasmodium falciparum importin beta, putative 0.0029 0.0034 0.012
Trichomonas vaginalis transmembrane protein nessy, putative 0.0026 0.0029 0.2142
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0002 0.00000034786
Schistosoma mansoni ran 0.0021 0.0021 0.0084
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0009 0.0026
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0025 0.0085
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0093 0.0339
Onchocerca volvulus 0.0029 0.0034 0.0032
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0009 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0093 0.0392
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0029 0.0368
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0033 0.0041 0.0145
Leishmania major glycerol uptake protein, putative 0.0026 0.0029 0.0075
Trichomonas vaginalis ran, putative 0.0021 0.0021 0.1537
Brugia malayi Cytochrome P450 family protein 0.0056 0.008 0.011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0015 0.0516
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.003 0.038
Onchocerca volvulus Twinkle protein, mitochondrial homolog 0.0024 0.0027 0.0025
Brugia malayi hypothetical protein 0.001 0.0002 0.0003
Echinococcus multilocularis sterol O acyltransferase 1 0.0264 0.0435 0.1583
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0029 0.0855
Onchocerca volvulus 0.0012 0.0005 0.0004
Echinococcus granulosus snurportin 1 0.0308 0.0511 0.2188
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0029 0.01
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0066 0.0091
Brugia malayi hypothetical protein 0.0472 0.079 0.1087
Brugia malayi Patched family protein 0.0012 0.0005 0.0007
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0015 0.0701
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.0679 0.2472
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0066 0.201
Brugia malayi CXXC zinc finger family protein 0.0029 0.0034 0.0047
Schistosoma mansoni niemann-pick C1 (NPC1) 0.02 0.0325 0.1388
Schistosoma mansoni hypothetical protein 0.0024 0.0027 0.0106
Toxoplasma gondii RNA-directed DNA polymerase 0.1606 0.2721 1
Brugia malayi cytochrome P450 0.0018 0.0015 0.0021
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0009 0.055
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0066 0.3369
Trypanosoma cruzi GUP1, putative 0.0026 0.0029 0.01
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0015 0.0516
Brugia malayi Patched related family protein 12 0.0012 0.0005 0.0007
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0015 0.0701
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0081 0.0123 0.0445
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0034 0.0428
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0114 0.0179 0.9309
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0015 0.0516
Brugia malayi Patched family protein 0.0012 0.0005 0.0007
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.003 0.0104
Loa Loa (eye worm) hypothetical protein 0.0238 0.0391 0.4948
Loa Loa (eye worm) hypothetical protein 0.0033 0.0041 0.0522
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0033 0.0041 0.0145
Onchocerca volvulus 0.0012 0.0005 0.0004
Schistosoma mansoni hypothetical protein 0.0081 0.0124 0.0523
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0029 0.01
Brugia malayi Patched family protein 0.0012 0.0005 0.0007
Brugia malayi Cytochrome P450 family protein 0.0026 0.003 0.0041
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0009 0.0177
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0009 0.0368
Echinococcus multilocularis Niemann Pick C1 protein 0.0281 0.0464 0.169
Loa Loa (eye worm) hypothetical protein 0.0298 0.0493 0.6248
Loa Loa (eye worm) hypothetical protein 0.0047 0.0066 0.0833
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0029 0.0855
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0009 0.0112
Toxoplasma gondii DNA polymerase I domain-containing protein 0.0033 0.0041 0.0145
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0066 0.3369
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0029 0.0368
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0009 0.0177
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Leishmania major glycerol uptake protein, putative 0.0026 0.0029 0.0075
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0015 0.0516
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0009 0.0368
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0029 0.0124
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0121 0.0192 0.0698
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0029 0.0105
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0066 0.201
Loa Loa (eye worm) patched family protein 0.0012 0.0005 0.0069
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0009 0.0368
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0114 0.0179 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0021 0.0614
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0129 0.0469
Echinococcus granulosus Niemann Pick C1 protein 0.0281 0.0464 0.1988
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0005 0.0013
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.0081 0.0123 0.042
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0009 0.0368
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0002 0.0006
Brugia malayi Hhat protein 0.0026 0.0029 0.004
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0015 0.0049
Echinococcus granulosus replication factor c subunit 1 0.001 0.0002 0.0007
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0093 0.1181
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0009 0.0012
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0015 0.0701
Echinococcus granulosus nibrin 0.001 0.0002 0.0007
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0009 0.0177
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1606 0.2721 1
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0026 0.0029 0.0124
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0025 0.1827
Brugia malayi hypothetical protein 0.0012 0.0005 0.0007
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0015 0.0516
Echinococcus granulosus Niemann Pick C1 protein 0.0197 0.032 0.1371
Onchocerca volvulus 0.0047 0.0066 0.0064
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0015 0.0516
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0009 0.0368
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0015 0.0049
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0093 0.0392
Loa Loa (eye worm) oxidoreductase 0.0014 0.0009 0.0112
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0129 0.1632
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0112
Onchocerca volvulus 0.0026 0.0029 0.0027
Brugia malayi Patched related family protein 4 0.0012 0.0005 0.0007
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0026 0.0029 0.0124
Loa Loa (eye worm) hypothetical protein 0.0029 0.0034 0.0435
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0066 0.3613
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0021 0.0072
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0077 0.0278
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0081 0.0123 0.0445
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0015 0.0049
Echinococcus granulosus microtubule associated protein 2 0.1378 0.2333 1
Plasmodium vivax importin-beta 2, putative 0.0029 0.0034 0.012
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0009 0.0368
Brugia malayi Patched family protein 0.0012 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Onchocerca volvulus 0.0012 0.0005 0.0004
Toxoplasma gondii patched family protein 0.0012 0.0005 0.0013
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0045 0.016
Mycobacterium leprae putative cytochrome p450 0.0018 0.0015 0.0752
Brugia malayi diacylglycerol acyltransferase 0.0026 0.0029 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0009 0.0368
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0009 0.0368
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0015 0.0701
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0009 0.0177
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0121 0.0192 0.0821
Echinococcus multilocularis muscleblind protein 0.0298 0.0493 0.1797
Onchocerca volvulus 0.0014 0.0009 0.0007
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0009 0.0368
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0009 0.0012
Entamoeba histolytica hypothetical protein 0.0026 0.0029 0.0855
Mycobacterium tuberculosis Probable 5'-3' exonuclease 0.0081 0.0123 0.6297
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0045 0.016
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0009 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0009 0.0368
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.0081 0.0123 0.0445
Brugia malayi CHE-14 protein 0.0084 0.0129 0.0177
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0034 0.0124
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0009 0.022
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Trichomonas vaginalis DNA polymerase I, putative 0.0033 0.0041 0.3101
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0025 0.1827
Entamoeba histolytica hypothetical protein 0.0023 0.0025 0.073
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0009 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0066 0.3369
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0575
Brugia malayi Patched protein homolog 1 0.0012 0.0005 0.0007
Brugia malayi protein C24B5.3 0.0012 0.0005 0.0007
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0026 0.0029 0.0105
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0045 0.2142
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0009 0.0012
Brugia malayi Patched family protein 0.0012 0.0005 0.0007
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0029 0.0117
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0015 0.0049
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0014 0.0009 0.0395
Mycobacterium ulcerans DNA polymerase I 0.0114 0.0179 0.9323
Toxoplasma gondii patched family protein 0.0012 0.0005 0.0013
Schistosoma mansoni hypothetical protein 0.0081 0.0124 0.0523
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0029 0.0855
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0009 0.0177
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0009 0.0112
Leishmania major GTP-binding protein, putative 0.0021 0.0021 0.0046
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0066 0.3613
Schistosoma mansoni hypothetical protein 0.0081 0.0124 0.0523
Entamoeba histolytica vacuolar protein sorting 26 0.0026 0.0029 0.0855
Brugia malayi RNA binding protein 0.0063 0.0093 0.0128
Schistosoma mansoni cytochrome P450 0.0018 0.0015 0.0057
Trypanosoma cruzi GUP1, putative 0.0026 0.0029 0.01
Leishmania major cytochrome p450-like protein 0.0026 0.003 0.0078
Brugia malayi Muscleblind-like protein 0.0298 0.0493 0.0679
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0034 0.012
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0015 0.0516
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0026 0.0029 0.0105
Schistosoma mansoni hypothetical protein 0.0072 0.0108 0.0453
Toxoplasma gondii aldehyde dehydrogenase 0.0121 0.0192 0.0698
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0197 0.032 1
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0129 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0029 0.2142
Echinococcus granulosus twinkle protein mitochondrial 0.0024 0.0027 0.0113
Entamoeba histolytica DNA-directed DNA polymerase, putative 0.0033 0.0041 0.1238
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0015 0.0516
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0014 0.0009 0.0395
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Brugia malayi DKFZp564C0469 protein 0.001 0.0002 0.0003
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0021 0.0072
Brugia malayi hypothetical protein 0.001 0.0002 0.0003
Echinococcus granulosus importin subunit beta 1 0.0029 0.0034 0.0146
Loa Loa (eye worm) hypothetical protein 0.0197 0.032 0.4054
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.008 0.1011
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0026 0.0029 0.0124
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0009 0.0177
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0149 0.0205
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0069
Brugia malayi topoisomerase 0.001 0.0002 0.0003
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0121 0.0192 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0023
Schistosoma mansoni cpg binding protein 0.0029 0.0034 0.0137
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0045 0.2295
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0114 0.0179 1
Echinococcus multilocularis snurportin 1 0.0308 0.0511 0.186
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0002 0.0003
Brugia malayi Cytochrome P450 family protein 0.0026 0.003 0.0041
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0026 0.0029 0.0368
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0009 0.0368
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0026 0.0029 0.01
Leishmania major telomerase reverse transcriptase, putative 0.1606 0.2721 1
Brugia malayi hypothetical protein 0.0012 0.0005 0.0007
Treponema pallidum DNA polymerase I (polA) 0.0114 0.0179 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.0025 0.006
Loa Loa (eye worm) hypothetical protein 0.0047 0.0066 0.0833
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0093 0.0392
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0015 0.0701
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0042 0.1965
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0129 1
Schistosoma mansoni hypothetical protein 0.0081 0.0124 0.0523
Loa Loa (eye worm) hypothetical protein 0.0026 0.0029 0.0368
Brugia malayi Importin beta-1 subunit 0.0029 0.0034 0.0047
Brugia malayi hypothetical protein 0.0012 0.0005 0.0007
Echinococcus granulosus survival motor neuron protein 1 0.0472 0.079 0.3384
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.003 0.038
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0015 0.0701
Toxoplasma gondii 5'-3' exonuclease, N-terminal resolvase family domain-containing protein 0.004 0.0053 0.0187
Brugia malayi TAR-binding protein 0.0063 0.0093 0.0128
Brugia malayi Patched family protein 0.0012 0.0005 0.0007
Loa Loa (eye worm) patched family protein 0.0012 0.0005 0.0069
Brugia malayi Patched family protein 0.0012 0.0005 0.0007
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0015 0.0701
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0192 0.0815
Entamoeba histolytica hypothetical protein 0.0072 0.0108 0.3321
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0015 0.0701
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0029 0.2142
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0081 0.0123 0.0445
Loa Loa (eye worm) hhat protein 0.0026 0.0029 0.0368
Entamoeba histolytica hypothetical protein 0.0072 0.0108 0.3321
Echinococcus multilocularis microtubule associated protein 2 0.1378 0.2333 0.8502
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0192 1
Echinococcus multilocularis nibrin 0.001 0.0002 0.0006
Schistosoma mansoni patched 1 0.0084 0.0129 0.0545
Loa Loa (eye worm) hypothetical protein 0.0047 0.0066 0.0833
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0023
Loa Loa (eye worm) patched family protein 0.0012 0.0005 0.0069
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0009 0.055
Leishmania major glycerol uptake protein, putative 0.0026 0.0029 0.0075
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0021 0.0072
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0015 0.0516
Echinococcus multilocularis protein patched 0.0084 0.0129 0.0469
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0026 0.0029 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0029 0.2142
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0009 0.0368
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0066 0.021
Loa Loa (eye worm) hypothetical protein 0.0103 0.0161 0.2042
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0023
Loa Loa (eye worm) hypothetical protein 0.0472 0.079 1
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0033 0.0041 0.0145
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0023
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0093 0.1181
Loa Loa (eye worm) hypothetical protein 0.0026 0.0029 0.0368
Brugia malayi Patched family protein 0.0012 0.0005 0.0007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0108 0.046
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0029 0.01
Chlamydia trachomatis DNA polymerase I 0.0114 0.0179 1
Schistosoma mansoni cpg binding protein 0.003 0.0037 0.0149
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0121 0.0192 0.0674
Onchocerca volvulus Protein patched homolog 0.0012 0.0005 0.0004
Mycobacterium ulcerans 5'-3' exonuclease 0.0081 0.0123 0.6369
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0009 0.0026
Plasmodium falciparum telomerase reverse transcriptase 0.1606 0.2721 1
Onchocerca volvulus Protein patched homolog 0.0012 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0023
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0021 0.0077
Echinococcus granulosus sterol O acyltransferase 1 0.0264 0.0435 0.1862

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 910 nM In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver. ChEMBL. 8691472
IC50 (binding) = 910 nM In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver. ChEMBL. 8691472

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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