Detailed information for compound 501842

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2237.54 | Formula: C97H157N31O28S
  • H donors: 35 H acceptors: 28 LogP: -12.4 Rotable bonds: 98
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CO)CCCCN)C)CCCNC(=N)N)CCC(=O)N)Cc1ccccc1)CO)[C@H](O)C)CCCCN)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]([C@H](O)C)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)N)Cc1ccc2c(c1)cccc2)CCCNC(=N)N)CC(=O)N)CCSC
  • InChi: 1S/C97H157N31O28S/c1-50(2)76(126-74(137)45-110-81(141)68(43-72(103)135)123-84(144)63(28-19-38-109-97(106)107)119-90(150)67(121-80(140)58(101)47-129)42-55-29-30-56-22-10-11-23-57(56)40-55)92(152)111-46-75(138)127-77(52(4)132)93(153)112-44-73(136)114-65(33-39-157-6)87(147)116-60(25-13-16-35-99)83(143)117-61(26-14-17-36-100)88(148)128-78(53(5)133)94(154)124-69(48-130)91(151)122-66(41-54-20-8-7-9-21-54)89(149)120-64(31-32-71(102)134)86(146)118-62(27-18-37-108-96(104)105)82(142)113-51(3)79(139)115-59(24-12-15-34-98)85(145)125-70(49-131)95(155)156/h7-11,20-23,29-30,40,50-53,58-70,76-78,129-133H,12-19,24-28,31-39,41-49,98-101H2,1-6H3,(H2,102,134)(H2,103,135)(H,110,141)(H,111,152)(H,112,153)(H,113,142)(H,114,136)(H,115,139)(H,116,147)(H,117,143)(H,118,146)(H,119,150)(H,120,149)(H,121,140)(H,122,151)(H,123,144)(H,124,154)(H,125,145)(H,126,137)(H,127,138)(H,128,148)(H,155,156)(H4,104,105,108)(H4,106,107,109)/t51-,52+,53+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,76-,77-,78-/m0/s1
  • InChiKey: NKVZZFVRRBLOPY-RCDGXIGVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus neuropeptide S receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis neuropeptides capa receptor neuropeptide S receptor 1 371 aa 330 aa 19.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.026 0.026
Echinococcus granulosus peroxisome assembly protein 26 0.01 0.159 0.159
Echinococcus granulosus tubulin alpha 0.0066 0.097 0.097
Loa Loa (eye worm) tubulin alpha-2 chain 0.01 0.159 0.262
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0044 0.0573 0.0573
Schistosoma mansoni cytochrome P450 0.0015 0.0041 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0256 0.1304
Schistosoma mansoni tubulin subunit epsilon 0.0066 0.097 0.1537
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.026 0.0429
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.026 0.0429
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0044 0.0573 0.3436
Echinococcus multilocularis tubulin alpha 0.0066 0.097 0.0969
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0019 0.0118 0.0195
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0809 0.1333
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0044 0.0573 1
Brugia malayi Cytochrome P450 family protein 0.0015 0.0041 0.0067
Schistosoma mansoni growth factor receptor-bound protein 0.0014 0.002 0.0031
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0016 0.0056 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.026 0.0429
Loa Loa (eye worm) hypothetical protein 0.0038 0.0464 0.0764
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0027 0.0256 0.0422
Loa Loa (eye worm) hypothetical protein 0.0027 0.026 0.0429
Mycobacterium ulcerans hypothetical protein 0.0026 0.0237 0.1754
Brugia malayi follicle stimulating hormone receptor 0.0254 0.4403 0.7256
Loa Loa (eye worm) tubulin alpha chain 0.01 0.159 0.262
Entamoeba histolytica hypothetical protein 0.0039 0.048 0.2763
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0016 0.0056 0.0056
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0177 0.3009 0.3009
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.091 1
Echinococcus multilocularis NCK adaptor protein 0.0014 0.002 0.0019
Loa Loa (eye worm) TK protein kinase 0.0033 0.0368 0.0607
Brugia malayi Tubulin alpha-2 chain 0.01 0.159 0.262
Echinococcus multilocularis tubulin delta chain 0.0032 0.0356 0.0356
Brugia malayi bHLH-PAS transcription factor 0.0076 0.1158 0.1908
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.026 0.026
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0028 0.0046
Echinococcus multilocularis beta tubulin 0.0081 0.1253 0.1253
Loa Loa (eye worm) hypothetical protein 0.0173 0.2921 0.4813
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0016 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0019 0.0118 0.0195
Mycobacterium ulcerans putative regulatory protein 0.0076 0.1158 1
Giardia lamblia Alpha-tubulin 0.01 0.159 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0256 0.0386
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0356 0.1958
Brugia malayi hypothetical protein 0.0139 0.2313 0.3812
Mycobacterium leprae Possible regulatory protein 0.0027 0.0256 0.4037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.026 0.0429
Echinococcus granulosus tubulin alpha chain 0.01 0.159 0.159
Entamoeba histolytica tubulin alpha chain, putative 0.01 0.159 1
Schistosoma mansoni tubulin subunit beta 0.0081 0.1253 0.1987
Plasmodium falciparum tubulin gamma chain 0.0094 0.1478 0.9271
Plasmodium vivax tubulin gamma chain, putative 0.0094 0.1478 0.9271
Echinococcus granulosus Tubulin beta 2C chain 0.0081 0.1253 0.1253
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0237 0.1754
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0809 0.1333
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0809 0.1333
Leishmania major beta tubulin 0.0081 0.1253 0.2179
Plasmodium falciparum alpha tubulin 1 0.01 0.159 1
Leishmania major beta tubulin 0.0081 0.1253 0.2179
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0016 0.0056 0.0056
Loa Loa (eye worm) cytochrome P450 0.0015 0.0041 0.0068
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0047 0.062 0.062
Loa Loa (eye worm) hypothetical protein 0.0027 0.026 0.0429
Schistosoma mansoni lamin 0.0057 0.0809 0.1282
Schistosoma mansoni tubulin subunit beta 0.0081 0.1253 0.1987
Loa Loa (eye worm) TK/ABL protein kinase 0.0222 0.3828 0.6309
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0044 0.0573 0.0573
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0237 0.039
Toxoplasma gondii alpha-tubulin I, putative 0.01 0.159 1
Trichomonas vaginalis tubulin beta chain, putative 0.01 0.159 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0016 0.0056 0.0092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.026 0.0429
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0046
Echinococcus multilocularis Tubulin beta 2C chain 0.0081 0.1253 0.1253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.026 0.0429
Echinococcus multilocularis Tubulin beta 2C chain 0.0081 0.1253 0.1253
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0256 0.1304
Schistosoma mansoni tubulin subunit beta 0.0032 0.0356 0.0565
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0464 0.2658
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0256 0.0386
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.026 0.026
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0047 0.062 0.062
Echinococcus granulosus tyrosine protein kinase Fyn 0.0047 0.062 0.062
Plasmodium falciparum tubulin delta chain, putative 0.0032 0.0356 0.1957
Trypanosoma brucei epsilon tubulin 0.0066 0.097 0.1669
Echinococcus granulosus tyrosine protein kinase Lyn 0.0047 0.0626 0.0626
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0046
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.026 0.0413
Trypanosoma cruzi beta tubulin, putative 0.0081 0.1253 0.2179
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0047 0.062 0.062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0118 0.0195
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.048 0.0479
Echinococcus granulosus tubulin gamma 1 chain 0.0094 0.1478 0.1478
Schistosoma mansoni tubulin subunit alpha 0.01 0.159 0.252
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0046
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.027 0.027
Echinococcus granulosus Tubulin alpha 1 chain 0.01 0.159 0.159
Trypanosoma cruzi epsilon tubulin, putative 0.0066 0.097 0.1669
Schistosoma mansoni intermediate filament proteins 0.0057 0.0809 0.1282
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0464 0.0759
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0032 0.0356 0.2035
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.026 0.0429
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.026 0.0413
Plasmodium vivax tubulin alpha chain, putative 0.01 0.159 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0016 0.0056 0.0027
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0464 0.0464
Schistosoma mansoni thyroid hormone receptor 0.0027 0.026 0.0413
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.026 0.0429
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.004 0.0496 0.0496
Brugia malayi Immunoglobulin I-set domain containing protein 0.0158 0.2648 0.4365
Trypanosoma cruzi alpha tubulin, putative 0.01 0.159 0.2783
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0237 0.118
Echinococcus multilocularis 0.0015 0.0041 0.0041
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.026 0.1057
Loa Loa (eye worm) TK protein kinase 0.004 0.0496 0.0817
Leishmania major beta tubulin 0.0081 0.1253 0.2179
Echinococcus granulosus tubulin beta 1 chain 0.0081 0.1253 0.1253
Echinococcus granulosus tubulin alpha chain 0.01 0.159 0.159
Echinococcus multilocularis tyrosine protein kinase Srms 0.004 0.0496 0.0495
Leishmania major alpha tubulin 0.01 0.159 0.2783
Trichomonas vaginalis tubulin beta chain, putative 0.01 0.159 1
Loa Loa (eye worm) beta-tubulin 0.0081 0.1253 0.2066
Echinococcus granulosus tubulin alpha 1C chain 0.01 0.159 0.159
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0464 0.2658
Echinococcus multilocularis tubulin alpha 1C chain 0.01 0.159 0.159
Trichomonas vaginalis tubulin alpha chain, putative 0.0066 0.097 0.5957
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0326 0.0536
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0016 0.0056 0.0097
Brugia malayi Variant SH3 domain containing protein 0.0014 0.002 0.0032
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0044 0.0573 0.0956
Giardia lamblia Alpha-tubulin 0.01 0.159 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.0028 0.0044
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0044 0.0573 0.3372
Schistosoma mansoni nuclear hormone receptor 0.0027 0.026 0.0413
Echinococcus granulosus intermediate filament protein 0.0057 0.0809 0.0809
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.026 0.0429
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0464 0.0463
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0028 0.0046
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0027 0.0256 0.0256
Plasmodium falciparum alpha tubulin 2 0.01 0.159 1
Schistosoma mansoni hypothetical protein 0.0144 0.2402 0.3808
Brugia malayi Tubulin gamma chain 0.0094 0.1478 0.2436
Toxoplasma gondii methionine aminopeptidase 0.0044 0.0573 0.3436
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0016 0.0056 0.0056
Leishmania major alpha tubulin 0.01 0.159 0.2783
Trypanosoma brucei methionine aminopeptidase, putative 0.0044 0.0573 0.0956
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0256 0.1304
Schistosoma mansoni nck2/grb4 0.0014 0.002 0.0031
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0464 0.2658
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0068 0.1001 0.6164
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0032
Echinococcus granulosus tyrosine protein kinase ABL1 0.0222 0.3828 0.3828
Loa Loa (eye worm) tubulin alpha-3 chain 0.0066 0.0976 0.1609
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0041 0.0068
Echinococcus granulosus tyrosine protein kinase Fyn 0.0047 0.062 0.062
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0044 0.0573 0.0909
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0044 0.0573 0.6122
Echinococcus granulosus tubulin delta chain 0.0032 0.0356 0.0356
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0044 0.0573 0.4766
Entamoeba histolytica protein kinase, putative 0.0033 0.0368 0.2036
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.026 0.0413
Echinococcus granulosus tyrosine kinase 0.004 0.0496 0.0496
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.026 0.0429
Plasmodium falciparum tubulin beta chain 0.0081 0.1253 0.7807
Trypanosoma brucei alpha tubulin 0.01 0.159 0.2783
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0262 0.0396
Leishmania major alpha tubulin 0.01 0.159 0.2783
Brugia malayi Cytochrome P450 family protein 0.0015 0.0041 0.0067
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0237 0.118
Echinococcus granulosus Tubulin alpha 1 chain 0.01 0.159 0.159
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.048 0.076
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0046
Echinococcus granulosus tyrosine protein kinase Src42A 0.0037 0.0444 0.0444
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.026 0.0429
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0256 0.1304
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.026 0.0429
Echinococcus granulosus tubulin alpha 3 chain 0.01 0.159 0.159
Echinococcus multilocularis tyrosine protein kinase HCK 0.0033 0.0368 0.0368
Echinococcus multilocularis tubulin alpha chain 0.01 0.159 0.159
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0044 0.0573 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0256 0.1304
Entamoeba histolytica tubulin family protein 0.0081 0.1253 0.7807
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0047 0.062 0.062
Echinococcus multilocularis tubulin alpha chain 0.01 0.159 0.159
Loa Loa (eye worm) alpha-tubulin 0.01 0.159 0.262
Loa Loa (eye worm) methionine aminopeptidase type I 0.0044 0.0573 0.0945
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0027 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0027 0.026 0.0429
Echinococcus granulosus tyrosine protein kinase Src42A 0.0047 0.062 0.062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0118 0.0195
Echinococcus multilocularis tubulin alpha 3 chain 0.01 0.159 0.159
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.026 0.0429
Echinococcus multilocularis neuropeptide receptor A26 0.056 1 1
Loa Loa (eye worm) hypothetical protein 0.01 0.159 0.262
Echinococcus granulosus tyrosine protein kinase Src64B 0.0047 0.062 0.062
Echinococcus granulosus tyrosine protein kinase Blk 0.004 0.0496 0.0496
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0044 0.0573 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0081 0.1253 0.7807
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0237 0.3681
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0237 0.1754
Loa Loa (eye worm) hypothetical protein 0.0027 0.026 0.0429
Echinococcus granulosus Tubulin beta 2C chain 0.0081 0.1253 0.1253
Trypanosoma cruzi zeta tubulin, putative 0.032 0.5605 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.026 0.026
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0068 0.1001 0.165
Leishmania major zeta tubulin, putative 0.032 0.5605 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0464 0.0764
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.026 0.0413
Echinococcus granulosus c src tyrosine kinase 0.0017 0.0071 0.0071
Onchocerca volvulus 0.0027 0.0256 0.1039
Echinococcus granulosus Tubulin alpha 1 chain 0.01 0.159 0.159
Leishmania major beta tubulin 0.0081 0.1253 0.2179
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0016 0.0056 0.0092
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0016 0.0056 0.0097
Brugia malayi PAS domain containing protein 0.0103 0.1646 0.2712
Onchocerca volvulus 0.0142 0.2365 0.9608
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0237 0.0352
Echinococcus multilocularis tubulin alpha chain 0.01 0.159 0.159
Brugia malayi hypothetical protein 0.0126 0.2073 0.3416
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0041 0.0068
Brugia malayi nuclear hormone receptor 0.0027 0.026 0.0429
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.026 0.0413
Onchocerca volvulus 0.0034 0.0381 0.1549
Loa Loa (eye worm) hypothetical protein 0.0019 0.0118 0.0195
Echinococcus granulosus growth factor receptor bound protein 2 0.0014 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0251 0.0414
Leishmania major beta tubulin 0.0081 0.1253 0.2179
Schistosoma mansoni hypothetical protein 0.0039 0.048 0.076
Echinococcus multilocularis Tubulin alpha 1 chain 0.01 0.159 0.159
Brugia malayi SRC-1 0.0047 0.062 0.1021
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0118 0.0692
Echinococcus multilocularis peroxisome assembly protein 26 0.01 0.159 0.159
Leishmania major alpha tubulin 0.01 0.159 0.2783
Brugia malayi steroid hormone receptor 0.0027 0.026 0.0429
Trypanosoma cruzi epsilon tubulin, putative 0.0066 0.097 0.1669
Echinococcus multilocularis tubulin alpha 3 chain 0.01 0.159 0.159
Echinococcus granulosus neuropeptide receptor A26 0.056 1 1
Echinococcus multilocularis tubulin subunit beta 0.0081 0.1253 0.1253
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0237 0.0352
Leishmania major alpha tubulin 0.01 0.159 0.2783
Trichomonas vaginalis tubulin epsilon chain, putative 0.01 0.159 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0222 0.3828 0.3828
Leishmania major alpha tubulin 0.01 0.159 0.2783
Mycobacterium ulcerans methionine aminopeptidase 0.0044 0.0573 0.4766
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0099 0.0669
Brugia malayi hypothetical protein 0.0039 0.048 0.079
Toxoplasma gondii beta-tubulin, putative 0.0081 0.1253 0.7828
Echinococcus multilocularis Tubulin beta 2C chain 0.0081 0.1253 0.1253
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0464 0.0759
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0014 0.002 0.0031
Onchocerca volvulus 0.0076 0.1158 0.4703
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0044 0.0573 0.6122
Giardia lamblia Beta tubulin 0.0081 0.1253 0.7273
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.026 0.026
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.026 0.026
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.091 0.1443
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0037 0.0444 0.0444
Leishmania major gamma-tubulin 0.0094 0.1478 0.2583
Schistosoma mansoni tyrosine kinase 0.0047 0.062 0.0983
Giardia lamblia Beta tubulin 0.0081 0.1253 0.7273
Leishmania major alpha tubulin 0.01 0.159 0.2783
Echinococcus granulosus beta tubulin 0.0081 0.1253 0.1253
Schistosoma mansoni hypothetical protein 0.0109 0.1764 0.2796
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0256 0.1304
Echinococcus granulosus roundabout 2 0.0015 0.0045 0.0045
Brugia malayi Tubulin beta chain 0.0034 0.0381 0.0628
Echinococcus multilocularis jun protein 0.0177 0.3009 0.3009
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0237 0.2253
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0044 0.0573 0.0956
Trypanosoma brucei zeta tubulin, putative 0.032 0.5605 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0254 0.4403 0.7256
Schistosoma mansoni tyrosine kinase 0.0215 0.37 0.5866
Trypanosoma cruzi tubulin delta chain 0.0032 0.0356 0.0566
Echinococcus granulosus tubulin subunit beta 0.0081 0.1253 0.1253
Brugia malayi Cell division protein ftsZ 0.0032 0.0356 0.0587
Loa Loa (eye worm) hypothetical protein 0.0026 0.0237 0.039
Trypanosoma cruzi zeta tubulin, putative 0.032 0.5605 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0027 0.0256 0.3023
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.026 0.0429
Echinococcus granulosus calcium dependent protein kinase 0.0015 0.005 0.005
Echinococcus granulosus NCK adaptor protein 0.0014 0.002 0.002
Brugia malayi tubulin alpha-2 chain 0.01 0.159 0.262
Echinococcus granulosus alpha tubulin 0.01 0.159 0.159
Toxoplasma gondii beta tubulin 0.0081 0.1253 0.7828
Echinococcus granulosus tubulin beta 4A class IVa 0.0081 0.1253 0.1253
Loa Loa (eye worm) tubulin beta-1 chain 0.0081 0.1253 0.2066
Echinococcus multilocularis calcium dependent protein kinase 0.0015 0.005 0.005
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0066 0.0976 0.6001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.026 0.0413
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0464 0.0871
Leishmania major alpha tubulin 0.01 0.159 0.2783
Trypanosoma brucei beta tubulin 0.0081 0.1253 0.2179
Toxoplasma gondii beta-1 tubulin, putative 0.0081 0.1253 0.7828
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0262 0.0396
Schistosoma mansoni tubulin subunit beta 0.0081 0.1253 0.1987
Onchocerca volvulus Tyrosine kinase homolog 0.0147 0.2461 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.01 0.159 0.159
Echinococcus granulosus beta tubulin 0.0081 0.1253 0.1253
Trichomonas vaginalis tubulin alpha chain, putative 0.0034 0.0381 0.2121
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0092
Echinococcus multilocularis aryl hydrocarbon receptor 0.0027 0.0256 0.0256
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0047 0.062 0.062
Echinococcus granulosus FTZ F1 alpha 0.0027 0.026 0.026
Leishmania major beta tubulin 0.0081 0.1253 0.2179
Loa Loa (eye worm) tubulin alpha 2 0.0034 0.0388 0.0639
Brugia malayi alpha-tubulin 0.01 0.159 0.262
Schistosoma mansoni protein kinase 0.0016 0.0056 0.0089
Echinococcus multilocularis tubulin alpha chain 0.01 0.159 0.159
Trichomonas vaginalis adenylate cyclase, putative 0.0027 0.0256 0.1304
Schistosoma mansoni tyrosine kinase 0.0017 0.0071 0.0113
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0464 0.2658
Trypanosoma cruzi tubulin delta chain 0.0032 0.0356 0.0566
Onchocerca volvulus Huntingtin homolog 0.0126 0.2073 0.8423
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.0028 0.0028
Trichomonas vaginalis tubulin alpha chain, putative 0.0034 0.0381 0.2121
Echinococcus granulosus Tubulin beta 2C chain 0.0081 0.1253 0.1253
Trypanosoma brucei beta tubulin 0.0066 0.097 0.1669
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.091 0.1443
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0081 0.1253 0.1253
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0464 0.0735
Trypanosoma brucei tubulin delta chain 0.0032 0.0356 0.0566
Loa Loa (eye worm) tubulin alpha 2 0.0068 0.1001 0.165
Brugia malayi hypoxia-induced factor 1 0.0318 0.558 0.9196
Echinococcus multilocularis geminin 0.0358 0.6309 0.6309
Brugia malayi Tubulin alpha-2 chain 0.01 0.159 0.262
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0027 0.0256 0.1304
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0066 0.097 0.5996
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0034 0.0381 0.2121
Brugia malayi tubulin alpha chain - mouse 0.01 0.159 0.262
Leishmania major beta tubulin 0.0081 0.1253 0.2179
Trypanosoma brucei tubulin gamma chain 0.0094 0.1478 0.2583
Echinococcus multilocularis hypothetical protein 0.01 0.159 0.159
Loa Loa (eye worm) hypothetical protein 0.0057 0.0809 0.1333
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0256 0.0386
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0047 0.062 0.062
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0158 0.2648 0.4365
Leishmania major alpha tubulin 0.01 0.159 0.2783
Onchocerca volvulus 0.0026 0.0237 0.0962
Loa Loa (eye worm) tubulin beta-2A chain 0.0081 0.1253 0.2066
Mycobacterium leprae cell division protein FtsZ 0.0032 0.0356 0.5923
Entamoeba histolytica tubulin alpha-1 chain 0.01 0.159 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0099 0.0669
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.026 0.0413
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0118 0.0889
Brugia malayi Tubulin alpha chain 0.0032 0.0356 0.0587
Schistosoma mansoni tubulin subunit delta 0.0032 0.0356 0.0565
Brugia malayi nuclear receptor NHR-88 0.0027 0.026 0.0429
Loa Loa (eye worm) hypothetical protein 0.0015 0.0045 0.0074
Trichomonas vaginalis tubulin, putative 0.0034 0.0381 0.2121
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0014 0.002 0.0032
Schistosoma mansoni hypothetical protein 0.0358 0.6309 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.01 0.159 1
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.026 0.0429
Loa Loa (eye worm) hypothetical protein 0.0068 0.1001 0.165
Trypanosoma brucei beta tubulin 0.0081 0.1253 0.2179
Mycobacterium ulcerans cell division protein FtsZ 0.0032 0.0356 0.2823
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.04 0.0659
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0044 0.0573 0.0573
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0017 0.0071 0.0113
Loa Loa (eye worm) alpha-tubulin 0.01 0.159 0.262
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0256 0.1304
Loa Loa (eye worm) hypothetical protein 0.0066 0.0976 0.1609
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0464 0.0463
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0262 0.0396
Trichomonas vaginalis tubulin beta chain, putative 0.01 0.159 1
Trichomonas vaginalis tubulin beta chain, putative 0.0034 0.0381 0.2121
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.026 0.0429
Leishmania major protein kinase, putative 0.0027 0.0262 0.0396
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.026 0.026
Schistosoma mansoni tyrosine kinase 0.0047 0.062 0.0983
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.027 0.027
Echinococcus multilocularis tubulin epsilon chain 0.0066 0.097 0.0969
Onchocerca volvulus 0.0027 0.026 0.1057
Schistosoma mansoni tubulin subunit beta 0.0081 0.1253 0.1987
Trichomonas vaginalis tubulin, putative 0.0034 0.0381 0.2121
Loa Loa (eye worm) tubulin beta-4 chain 0.0081 0.1253 0.2066
Brugia malayi hypothetical protein 0.0014 0.0028 0.0046
Leishmania major protein kinase, putative 0.0027 0.0262 0.0396
Echinococcus granulosus single minded 2 0.0076 0.1158 0.1158
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.026 0.0429
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0044 0.0573 0.0909
Brugia malayi Tubulin beta-1 chain 0.0081 0.1253 0.2066
Schistosoma mansoni jun-related protein 0.0144 0.2402 0.3808
Echinococcus granulosus lamin dm0 0.0057 0.0809 0.0809
Echinococcus multilocularis transfer RNA-Lys 0.0076 0.1158 0.1157
Loa Loa (eye worm) hypothetical protein 0.0026 0.0251 0.0414
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0237 0.118
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0464 0.0759
Brugia malayi Tyrosine-protein kinase abl-1 0.0098 0.1555 0.2563
Loa Loa (eye worm) BEN-1 protein 0.0081 0.1253 0.2066
Trichomonas vaginalis tubulin beta chain, putative 0.01 0.159 1
Trypanosoma brucei alpha tubulin 0.01 0.159 0.2783
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0027 0.0256 0.1304
Schistosoma mansoni tubulin subunit beta 0.0081 0.1253 0.1987
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0464 0.0759
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.091 0.7785
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0044 0.0573 0.3372
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0014 0.002 0.0032
Schistosoma mansoni hypothetical protein 0.0358 0.6309 1
Brugia malayi hypothetical protein 0.0014 0.0028 0.0046
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.026 0.1057
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0262 0.0396
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0237 0.039
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0464 0.0464
Plasmodium vivax tubulin epsilon chain, putative 0.0066 0.097 0.5957
Giardia lamblia Beta tubulin 0.0081 0.1253 0.7273
Trichomonas vaginalis tubulin gamma chain, putative 0.0094 0.1478 0.9271
Echinococcus multilocularis tyrosine protein kinase Blk 0.004 0.0496 0.0495
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0044 0.0573 0.0956
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.026 0.0429
Echinococcus granulosus geminin 0.0358 0.6309 0.6309
Schistosoma mansoni tyrosine kinase 0.0017 0.0071 0.0113
Loa Loa (eye worm) tubulin gamma chain 0.0094 0.1478 0.2436
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.091 0.091
Echinococcus granulosus tubulin alpha 1C chain 0.01 0.159 0.159
Leishmania major beta tubulin 0.0081 0.1253 0.2179
Trypanosoma brucei zeta tubulin 0.032 0.5605 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0032 0.0356 0.1958
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0041 0.0041
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0118 0.0406
Schistosoma mansoni adapter molecule crk 0.0014 0.002 0.0031
Leishmania major epsilon tubulin, putative 0.0066 0.097 0.1669
Echinococcus multilocularis tubulin beta 1 chain 0.0081 0.1253 0.1253
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0044 0.0573 1
Toxoplasma gondii alpha tubulin TUBA1 0.01 0.159 1
Echinococcus multilocularis musashi 0.0057 0.0809 0.0809
Trichomonas vaginalis tubulin epsilon chain, putative 0.0032 0.0356 0.1958
Brugia malayi intermediate filament protein 0.0057 0.0809 0.1333
Leishmania major alpha tubulin 0.01 0.159 0.2783
Brugia malayi ecdysteroid receptor 0.0027 0.026 0.0429
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0464 0.0463
Leishmania major protein kinase, putative 0.0016 0.0056 0.0027
Schistosoma mansoni growth factor receptor-bound protein 0.0014 0.002 0.0031
Onchocerca volvulus 0.0057 0.0809 0.3286
Entamoeba histolytica tubulin gamma chain 0.0094 0.1478 0.9271
Trypanosoma brucei alpha tubulin 0.01 0.159 0.2783
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.026 0.026
Leishmania major alpha tubulin 0.01 0.159 0.2783
Trichomonas vaginalis tubulin, putative 0.0081 0.1253 0.7807
Schistosoma mansoni tubulin subunit alpha 0.0032 0.0356 0.0565
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0056 0.0089
Loa Loa (eye worm) hypothetical protein 0.0126 0.2073 0.3416
Giardia lamblia Gamma tubulin 0.0094 0.1478 0.9094
Brugia malayi nuclear receptor RXR 0.0014 0.0028 0.0046
Loa Loa (eye worm) BEN-1 protein 0.0081 0.1253 0.2066
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0017 0.0071 0.0071
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0016 0.0056 0.0056
Entamoeba histolytica hypothetical protein 0.0039 0.048 0.2763
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0016 0.0056 0.0097
Trichomonas vaginalis tubulin beta chain, putative 0.01 0.159 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0045 0.0074
Echinococcus granulosus tyrosine protein kinase Fyn 0.0047 0.062 0.062
Loa Loa (eye worm) tubulin alpha chain 0.01 0.159 0.262
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.026 0.1057
Echinococcus granulosus tubulin alpha chain 0.01 0.159 0.159
Brugia malayi cytochrome P450 0.0015 0.0041 0.0067
Trichomonas vaginalis tubulin beta chain, putative 0.0081 0.1253 0.7807
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.026 0.026
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0044 0.0573 0.3372
Schistosoma mansoni single-minded 0.0103 0.1646 0.2609
Trichomonas vaginalis tubulin epsilon chain, putative 0.01 0.159 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.01 0.159 0.159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.026 0.0429
Trichomonas vaginalis tubulin, putative 0.006 0.0865 0.5272
Schistosoma mansoni alpha tubulin 0.01 0.159 0.252
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.026 0.026
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.026 0.026
Leishmania major alpha tubulin 0.01 0.159 0.2783
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.0028 0.0046
Echinococcus multilocularis tyrosine protein kinase Abl 0.0098 0.1555 0.1555
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0237 0.1754
Leishmania major delta tubulin, putative 0.0032 0.0356 0.0566
Brugia malayi bZIP transcription factor family protein 0.0177 0.3009 0.496
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0496 0.0495
Trypanosoma brucei epsilon tubulin 0.0066 0.097 0.1669
Echinococcus multilocularis growth factor receptor bound protein 2 0.0014 0.002 0.0019
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0464 0.0735
Loa Loa (eye worm) hypothetical protein 0.0056 0.079 0.1302
Echinococcus granulosus jun protein 0.0177 0.3009 0.3009
Trypanosoma brucei alpha tubulin, putative 0.0034 0.0381 0.0611
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.026 0.026
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.091 0.1562
Loa Loa (eye worm) SRC-1 0.0047 0.062 0.1022
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0047 0.062 0.062
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.048 0.048
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.026 0.0413
Leishmania major beta tubulin 0.0081 0.1253 0.2179
Brugia malayi Sex muscle abnormal protein 5 0.0014 0.002 0.0032
Echinococcus multilocularis lamin dm0 0.0057 0.0809 0.0809
Entamoeba histolytica hypothetical protein 0.0039 0.048 0.2763
Loa Loa (eye worm) hypothetical protein 0.0027 0.026 0.0429
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0177 0.3009 0.3009
Echinococcus granulosus lamin 0.0057 0.0809 0.0809
Echinococcus multilocularis Tubulin beta 2C chain 0.0081 0.1253 0.1253
Brugia malayi Cytochrome P450 family protein 0.0015 0.0041 0.0067
Brugia malayi Methionine aminopeptidase protein type I 0.0044 0.0573 0.0944
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.026 0.026
Trypanosoma brucei alpha tubulin 0.01 0.159 0.2783
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0237 0.1754
Loa Loa (eye worm) hypothetical protein 0.0345 0.6068 1
Echinococcus multilocularis beta tubulin 0.0081 0.1253 0.1253
Treponema pallidum methionine aminopeptidase (map) 0.0044 0.0573 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.0028 0.0028
Trichomonas vaginalis tubulin gamma chain, putative 0.0066 0.097 0.5957
Mycobacterium tuberculosis Cell division protein FtsZ 0.0032 0.0356 0.3626
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0256 0.1304
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.026 0.026
Trichomonas vaginalis tubulin beta chain, putative 0.01 0.159 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0237 0.039
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.026 0.026
Echinococcus multilocularis tubulin subunit TubB 0.01 0.159 0.159
Leishmania major beta tubulin 0.0081 0.1253 0.2179
Echinococcus multilocularis Tubulin beta 2C chain 0.0081 0.1253 0.1253
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0237 0.1754
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0237 0.2253
Brugia malayi Tyrosine-protein kinase abl-1 0.0131 0.2165 0.3568
Plasmodium vivax tubulin alpha chain, putative 0.01 0.159 1
Schistosoma mansoni tubulin subunit beta 0.0081 0.1253 0.1987
Onchocerca volvulus Huntingtin homolog 0.0126 0.2073 0.8423
Leishmania major beta tubulin 0.0081 0.1253 0.2179
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.026 0.026
Loa Loa (eye worm) tubulin alpha 2 0.0068 0.1001 0.165
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.026 0.0429
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.091 0.7785
Brugia malayi Variant SH3 domain containing protein 0.0014 0.002 0.0032
Schistosoma mansoni coup transcription factor 0.0027 0.026 0.0413
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0017 0.0071 0.0071
Leishmania major beta tubulin 0.0081 0.1253 0.2179
Chlamydia trachomatis methionine aminopeptidase 0.0044 0.0573 1
Brugia malayi Tubulin beta chain 0.0032 0.0356 0.0587
Plasmodium vivax delta tubulin, putative 0.0032 0.0356 0.1957
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0044 0.0573 0.0956
Brugia malayi Cam kinase protein 1 0.0016 0.0056 0.0092
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0099 0.0669
Echinococcus granulosus aryl hydrocarbon receptor 0.0027 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0084 0.1303 0.2148
Loa Loa (eye worm) tubulin beta chain 0.0032 0.0356 0.0587
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.091 0.7785
Plasmodium vivax tubulin beta chain, putative 0.0081 0.1253 0.7807
Echinococcus granulosus tubulin epsilon chain 0.0066 0.097 0.097
Loa Loa (eye worm) hypothetical protein 0.0026 0.0237 0.039
Brugia malayi Cytochrome P450 family protein 0.0035 0.04 0.0659
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0237 0.3681
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0356 0.1958
Echinococcus granulosus tubulin alpha 3 chain 0.01 0.159 0.159
Echinococcus multilocularis lamin 0.0057 0.0809 0.0809
Schistosoma mansoni alpha tubulin 0.01 0.159 0.252
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0041 0.0068
Trypanosoma cruzi tubulin gamma chain 0.0094 0.1478 0.2583
Echinococcus multilocularis tubulin gamma 1 chain 0.0094 0.1478 0.1478
Trypanosoma brucei epsilon tubulin 0.0066 0.097 0.1669
Onchocerca volvulus 0.0057 0.0809 0.3286
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0046
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.026 0.0413
Echinococcus granulosus Tubulin beta 2C chain 0.0081 0.1253 0.1253
Entamoeba histolytica hypothetical protein 0.0039 0.048 0.2763
Schistosoma mansoni aryl hydrocarbon receptor 0.0103 0.1646 0.2609
Echinococcus granulosus tubulin alpha chain 0.01 0.159 0.159
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0464 0.0464
Echinococcus multilocularis roundabout 2 0.0015 0.0045 0.0045
Trichomonas vaginalis tubulin alpha chain, putative 0.0034 0.0381 0.2121
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0047 0.062 0.062
Trichomonas vaginalis tubulin alpha chain, putative 0.0081 0.1253 0.7807
Loa Loa (eye worm) hypothetical protein 0.0027 0.026 0.0429
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.026 0.0429
Echinococcus granulosus tubulin alpha chain 0.01 0.159 0.159
Trypanosoma brucei beta tubulin 0.0081 0.1253 0.2179
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0326 0.0536
Brugia malayi hypothetical protein 0.0345 0.6068 1
Loa Loa (eye worm) tubulin beta chain 0.0081 0.1253 0.2066
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0016 0.0056 0.0056
Trichomonas vaginalis tubulin gamma chain, putative 0.0081 0.1253 0.7807
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.026 0.0429
Echinococcus granulosus tubulin subunit TubB 0.01 0.159 0.159
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0118 0.0406
Leishmania major beta tubulin 0.0081 0.1253 0.2179
Leishmania major beta tubulin 0.0081 0.1253 0.2179
Loa Loa (eye worm) hypothetical protein 0.0027 0.026 0.0429
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0028 0.0044
Echinococcus granulosus tyrosine protein kinase HCK 0.0033 0.0368 0.0368
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0237 0.1754
Schistosoma mansoni thyroid hormone receptor 0.0027 0.026 0.0413
Plasmodium falciparum tubulin epsilon chain, putative 0.0066 0.097 0.5957
Loa Loa (eye worm) hypothetical protein 0.0028 0.027 0.0445
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0047 0.062 0.062
Schistosoma mansoni tubulin subunit alpha 0.01 0.159 0.252
Toxoplasma gondii methionine aminopeptidase 0.0044 0.0573 0.3436
Trypanosoma brucei beta tubulin 0.0081 0.1253 0.2179
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0032 0.0356 0.1958
Brugia malayi beta-tubulin, identical 0.0081 0.1253 0.2066
Schistosoma mansoni lamin 0.0057 0.0809 0.1282
Leishmania major beta tubulin 0.0081 0.1253 0.2179
Echinococcus multilocularis neuropeptide s receptor 0.056 1 1
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0044 0.0573 0.3372
Entamoeba histolytica tubulin family protein 0.0081 0.1253 0.7807
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0099 0.0669
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0237 0.039
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.026 0.026
Schistosoma mansoni protein kinase 0.0016 0.0056 0.0089
Echinococcus multilocularis tubulin alpha chain 0.01 0.159 0.159
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0047 0.062 0.062
Leishmania major beta tubulin 0.0081 0.1253 0.2179
Onchocerca volvulus 0.0139 0.2313 0.9399
Brugia malayi protein-tyrosine kinase 0.004 0.0496 0.0817
Loa Loa (eye worm) hypothetical protein 0.0027 0.026 0.0429
Schistosoma mansoni tubulin subunit gamma 0.0094 0.1478 0.2343
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0047 0.062 0.062
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0032 0.0356 0.2035
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0237 0.0352
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.0065
Brugia malayi Tubulin alpha chain 0.01 0.159 0.262
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0016 0.0056 0.0056
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.026 0.0429
Loa Loa (eye worm) hypothetical protein 0.0126 0.2073 0.3416
Schistosoma mansoni alpha tubulin 0.01 0.159 0.252
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.026 0.0429
Schistosoma mansoni tubulin subunit alpha 0.01 0.159 0.252
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0237 0.1754
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.091 0.5613
Trichomonas vaginalis tubulin epsilon chain, putative 0.0081 0.1253 0.7807
Loa Loa (eye worm) hypothetical protein 0.0027 0.0256 0.0422
Leishmania major beta tubulin 0.0081 0.1253 0.2179
Echinococcus multilocularis tubulin alpha 1C chain 0.01 0.159 0.159
Schistosoma mansoni protein kinase 0.0016 0.0056 0.0089
Echinococcus granulosus Tubulin beta 2C chain 0.0081 0.1253 0.1253
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0016 0.0056 0.0056
Echinococcus multilocularis c src tyrosine kinase 0.0017 0.0071 0.0071
Leishmania major beta tubulin 0.0081 0.1253 0.2179
Loa Loa (eye worm) hypoxia-induced factor 1 0.0318 0.558 0.9196

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = -8.66 Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization ChEMBL. 18181564
Emax (functional) = 213 % Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization relative to baseline ChEMBL. 18181564
Emax (functional) = 213 % Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization relative to baseline ChEMBL. 18181564
Log EC50 (functional) = 8.66 Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization ChEMBL. 18181564

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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