Detailed information for compound 53552

Basic information

Technical information
  • TDR Targets ID: 53552
  • Name: N-[4-(4-nitrophenoxy)-4-oxo-3,5-dioxa-4$l^{5} -phosphacyclohex-1-yl]acetamide
  • MW: 316.204 | Formula: C11H13N2O7P
  • H donors: 1 H acceptors: 4 LogP: 0.32 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)NC1COP(=O)(OC1)Oc1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C11H13N2O7P/c1-8(14)12-9-6-18-21(17,19-7-9)20-11-4-2-10(3-5-11)13(15)16/h2-5,9H,6-7H2,1H3,(H,12,14)
  • InChiKey: RNJBQFXJWNZBOL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-(4-nitrophenoxy)-4-oxo-3,5-dioxa-4$l^{5}-phosphacyclohex-1-yl]ethanamide
  • N-[4-keto-4-(4-nitrophenoxy)-3,5-dioxa-4$l^{5}-phosphacyclohex-1-yl]acetamide
  • N-[2-(4-nitrophenoxy)-2-oxo-1,3-dioxa-2$l^{5}-phosphacyclohex-5-yl]acetamide
  • N-[2-keto-2-(4-nitrophenoxy)-1,3-dioxa-2$l^{5}-phosphacyclohex-5-yl]acetamide
  • N-[2-(4-nitrophenoxy)-2-oxo-1,3-dioxa-2$l^{5}-phosphacyclohex-5-yl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.002 0.0016 0.0007
Brugia malayi serine/threonine-protein kinase plk-2 0.02 0.0541 0.2213
Loa Loa (eye worm) hypothetical protein 0.0049 0.0099 0.0299
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0182 0.0489 0.2004
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0015 0.0044
Loa Loa (eye worm) hypothetical protein 0.0075 0.0175 0.0525
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0374 0.1479
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0089 0.0217 0.1786
Brugia malayi Cytochrome P450 family protein 0.0031 0.0047 0.0192
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0089 0.0217 0.0577
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0047 0.0046
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0066 0.0271
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0068 0.0219
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0182 0.0489 1
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.005 0.0102 0.0306
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0046 0.0639
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0142 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.0217 0.0833
Schistosoma mansoni axis inhibition protein axin 0.002 0.0015 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0142 0.0525
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0021 0.0025
Loa Loa (eye worm) phosphatidylinositol 3 0.036 0.1008 0.303
Brugia malayi hypothetical protein 0.0491 0.1391 0.5697
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0033 0.0054 0.0054
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0046 0.0268
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0038 0.0068 0.0426
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0089 0.0217 0.0217
Echinococcus multilocularis Zinc finger, PHD finger 0.0182 0.0489 0.0489
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0033 0.0054 0.0054
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0099 0.0245 0.0651
Loa Loa (eye worm) hypothetical protein 0.014 0.0366 0.11
Schistosoma mansoni regulator of G protein signaling 0.002 0.0015 0.0039
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.033 0.092 0.7331
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0053 0.0112 0.0852
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0335 0.0935 0.0935
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0851 0.2442 1
Schistosoma mansoni regulator of G protein signaling 0.002 0.0015 0.0039
Loa Loa (eye worm) hypothetical protein 0.0075 0.0175 0.0525
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0044
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0015 0.0061
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0401 0.1129 0.3004
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0064 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0075 0.0175 0.0525
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0143 0.0374 0.756
Schistosoma mansoni lamin 0.0028 0.0038 0.01
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0024 0.0025 0.0075
Echinococcus granulosus casein kinase ii subunit beta 0.0038 0.0068 0.0068
Trypanosoma brucei polo-like protein kinase 0.02 0.0541 0.4258
Schistosoma mansoni hypothetical protein 0.0026 0.0032 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0305 0.1197
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.005 0.0102 0.0271
Loa Loa (eye worm) RecQ helicase 0.0022 0.0021 0.0063
Plasmodium vivax hypothetical protein 0.0089 0.0217 0.4253
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.0027 0.007
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0374 0.1479
Mycobacterium ulcerans zinc metalloprotease 0.0099 0.0245 0.8432
Echinococcus granulosus single minded 2 0.0038 0.0066 0.0066
Onchocerca volvulus 0.0105 0.0262 0.2802
Schistosoma mansoni single-minded 0.0051 0.0105 0.0278
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0142 0.0525
Plasmodium falciparum glycogen synthase kinase 3 0.0053 0.0112 0.2073
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0038 0.0155
Schistosoma mansoni serine/threonine protein kinase 0.0335 0.0935 0.2489
Echinococcus multilocularis survival motor neuron protein 1 0.0491 0.1391 0.1391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.106 0.4304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0413 0.1165 0.4737
Echinococcus granulosus lamin 0.0028 0.0038 0.0038
Loa Loa (eye worm) phosphatidylinositol kinase 0.0089 0.0217 0.0653
Plasmodium vivax unspecified product 0.0143 0.0374 0.756
Trichomonas vaginalis PIKK family atypical protein kinase 0.0442 0.1249 0.5084
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0093 0.0228 0.0228
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0182 0.0489 0.1955
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0442 0.1249 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0021 0.0025
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0015 0.0015
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0043 0.0083 0.0281
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.0181 0.0181
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0015 0.0015
Plasmodium falciparum casein kinase II beta chain 0.0038 0.0068 0.1155
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0288 0.0826
Trichomonas vaginalis PIKK family atypical protein kinase 0.0294 0.0816 0.33
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0625 0.1782 0.7281
Plasmodium falciparum casein kinase II beta chain 0.0038 0.0068 0.1155
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0064 0.0142 0.0525
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0224 0.0611 0.4826
Leishmania major hypothetical protein, conserved 0.1276 0.3685 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0053 0.0112 0.0336
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0047 0.0046
Trichomonas vaginalis CAMK family protein kinase 0.02 0.0541 0.2166
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0236 0.0647 0.4606
Trichomonas vaginalis CAMK family protein kinase 0.01 0.025 0.0968
Trichomonas vaginalis PIKK family atypical protein kinase 0.0413 0.1165 0.4737
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0047 0.0123
Schistosoma mansoni regulator of G protein signaling 0.002 0.0015 0.0039
Echinococcus granulosus geminin 0.0175 0.0468 0.0468
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0064 0.0142 0.1029
Entamoeba histolytica protein kinase rad3, putative 0.0209 0.0566 0.2271
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0089 0.0217 0.1786
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0038 0.0068 0.0465
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0105 0.0278
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0024 0.0027 0.007
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0046 0.0128
Echinococcus multilocularis cyclin dependent kinase 19 0.014 0.0364 0.0364
Schistosoma mansoni fkbp-rapamycin associated protein 0.0209 0.0566 0.1506
Plasmodium falciparum casein kinase 2, alpha subunit 0.0143 0.0374 0.7574
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0099 0.0245 0.1003
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.0027 0.007
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0 0.000000011352
Loa Loa (eye worm) phosphatidylinositol 3 0.1153 0.3327 1
Onchocerca volvulus 0.0052 0.0107 0.1143
Brugia malayi follicle stimulating hormone receptor 0.0247 0.0677 0.2771
Entamoeba histolytica hypothetical protein 0.0038 0.0066 0.0211
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.0288 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0064 0.0142 0.0525
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0024 0.0025 0.0103
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0064 0.0142 0.0142
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0033 0.0054 0.0054
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.014 0.0364 0.1094
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0015 0.0046
Echinococcus multilocularis endothelin converting enzyme 1 0.0099 0.0245 0.0245
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.3437 1 1
Echinococcus granulosus expressed conserved protein 0.017 0.0454 0.0454
Giardia lamblia Kinase, CMGC GSK 0.0053 0.0112 0.0504
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0073 0.017 0.051
Brugia malayi Peptidase family M13 containing protein 0.0099 0.0245 0.1003
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0015 0.0061
Loa Loa (eye worm) hypothetical protein 0.0295 0.0819 0.2462
Onchocerca volvulus 0.0089 0.0217 0.2319
Echinococcus granulosus protein kinase shaggy 0.0053 0.0112 0.0112
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0761 0.2181 0.8926
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0047 0.0274
Schistosoma mansoni hypothetical protein 0.0026 0.0032 0.0084
Plasmodium vivax casein kinase II beta chain, putative 0.0038 0.0068 0.1106
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0442 0.1249 0.5113
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0044
Onchocerca volvulus Serine\/threonine kinase homolog 0.02 0.0541 0.5778
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.0003
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0046 0.0128
Onchocerca volvulus 0.0105 0.0262 0.2802
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0142 0.0525
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0288 0.0765
Schistosoma mansoni hypothetical protein 0.014 0.0366 0.0973
Schistosoma mansoni hypothetical protein 0.0026 0.0032 0.0084
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0648 0.1851 0.5563
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0182 0.0489 0.1955
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0182 0.0489 0.1955
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.033 0.092 0.3728
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0046 0.5
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0038 0.0114
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0116
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0093 0.0228 0.0228
Brugia malayi intracellular kinase 0.0053 0.0112 0.0457
Schistosoma mansoni voltage-gated cation channel 0.0033 0.0054 0.0143
Schistosoma mansoni protein kinase 0.0143 0.0374 0.0994
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0089 0.0217 0.4253
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0288 0.1124
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.005 0.0102 0.0271
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0068 0.0219
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0064 0.0142 0.0401
Loa Loa (eye worm) phosphatidylinositol 3 0.0089 0.0217 0.0653
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0089 0.0217 0.1635
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.0181 0.0181
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0374 0.1479
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0068 0.0219
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0851 0.2442 0.7127
Onchocerca volvulus 0.0043 0.0081 0.0864
Schistosoma mansoni neprilysin-2 (M13 family) 0.005 0.0102 0.0271
Onchocerca volvulus 0.0049 0.0099 0.106
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0288 0.1124
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0015 0.0061
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0068 0.0219
Entamoeba histolytica protein kinase, putative 0.0053 0.0112 0.0399
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0044
Loa Loa (eye worm) hypothetical protein 0.0603 0.1718 0.5164
Brugia malayi 6-phosphofructokinase 0.0113 0.0288 0.1178
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.0288 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0028 0.0038 0.0102
Brugia malayi Uncoordinated protein 44 0.0015 0 0.0001
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0182 0.0489 0.1315
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0121
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0089 0.0217 0.4253
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0442 0.1249 0.1249
Mycobacterium ulcerans putative regulatory protein 0.002 0.0016 0.0007
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0442 0.1249 0.5084
Brugia malayi Pre-SET motif family protein 0.0031 0.0047 0.0191
Toxoplasma gondii FATC domain-containing protein 0.0224 0.0611 0.5276
Loa Loa (eye worm) phosphatidylinositol 3 0.0442 0.1249 0.3754
Schistosoma mansoni ankyrin 23/unc44 0.0015 0 0.000000030215
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0038 0.0068 0.0725
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0 0.000000011352
Loa Loa (eye worm) Csnk2b protein 0.0038 0.0068 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0349 0.0975 0.3958
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0089 0.0217 0.0217
Loa Loa (eye worm) calcium channel 0.0033 0.0054 0.0162
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0015 0.003
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0401 0.1129 0.3286
Plasmodium vivax casein kinase II beta chain, putative 0.0038 0.0068 0.1106
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0064 0.0142 0.0525
Entamoeba histolytica hypothetical protein 0.0089 0.0217 0.0833
Brugia malayi Protein kinase domain containing protein 0.014 0.0364 0.1491
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.0288 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0442 0.1249 0.3379
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0015 0.0015
Echinococcus multilocularis casein kinase ii subunit beta 0.0038 0.0068 0.0068
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0053 0.0112 0.0112
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0229 0.0626 0.5417
Echinococcus granulosus serine protein kinase ATM 0.0224 0.0611 0.061
Schistosoma mansoni hypothetical protein 0.0026 0.0032 0.0084
Toxoplasma gondii target of rapamycin (TOR), putative 0.0406 0.1143 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0851 0.2442 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0349 0.0975 0.7784
Entamoeba histolytica hypothetical protein 0.0038 0.0066 0.0211
Loa Loa (eye worm) hypothetical protein 0.0015 0 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0119 0.0431
Echinococcus multilocularis beta adrenergic receptor kinase 0.0024 0.0025 0.0025
Plasmodium vivax hypothetical protein, conserved 0.0089 0.0217 0.4253
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0142 0.0525
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0182 0.0489 0.1955
Leishmania major hypothetical protein, unknown function 0.0089 0.0217 0.0576
Brugia malayi hypothetical protein 0.002 0.0015 0.0061
Trypanosoma cruzi casein kinase II, putative 0.0143 0.0374 0.1078
Plasmodium falciparum GAF domain-related protein, putative 0.002 0.0016 0.0055
Echinococcus granulosus endothelin converting enzyme 1 0.0099 0.0245 0.0245
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0064 0.0142 0.1029
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0053 0.0112 0.0297
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0046 0.0128
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0038 0.0068 0.0184
Leishmania major cytochrome p450-like protein 0.002 0.0015 0.0028
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0089 0.0217 0.0577
Entamoeba histolytica protein kinase domain containing protein 0.0143 0.0374 0.1479
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0142 0.0525
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0068 0.0219
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0015 0.0015
Echinococcus granulosus high voltage activated calcium channel beta 0.009 0.0221 0.022
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0089 0.0217 0.0889
Loa Loa (eye worm) phosphatidylinositol 3 0.0089 0.0217 0.0653
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0046 0.5
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0142 0.0525
Trichomonas vaginalis CAMK family protein kinase 0.01 0.025 0.0968
Trypanosoma cruzi polo-like protein kinase, putative 0.02 0.0541 0.1566
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0081 0.0215
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0851 0.2442 1
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0374 0.1479
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0089 0.0217 0.0833
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0021 0.0021
Brugia malayi Pre-SET motif family protein 0.0215 0.0585 0.2395
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0068 0.0219
Loa Loa (eye worm) hypothetical protein 0.071 0.2031 0.6106
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0033 0.0054 0.0143
Entamoeba histolytica hypothetical protein 0.0038 0.0066 0.0211
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0142 0.0525
Entamoeba histolytica hypothetical protein 0.0224 0.0611 0.2455
Schistosoma mansoni serine/threonine protein kinase 0.02 0.0541 0.1438
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0015 0.0015
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0089 0.0217 0.062
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.033 0.092 0.3728
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.02 0.0541 0.1625
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0068 0.0219
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0603 0.1718 0.1718
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0442 0.1249 0.3323
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0335 0.0935 0.2811
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0401 0.1129 0.1128
Schistosoma mansoni regulator of G protein signaling 0.002 0.0015 0.0039
Loa Loa (eye worm) hypothetical protein 0.0073 0.017 0.051
Brugia malayi Angiotensin-converting enzyme family protein 0.0648 0.1851 0.7579
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0209 0.0566 0.0566
Echinococcus multilocularis expressed conserved protein 0.017 0.0454 0.0454
Brugia malayi hypothetical protein 0.0105 0.0263 0.1075
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0038 0.0068 0.0725
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0143 0.0374 0.1123
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.033 0.092 0.3766
Loa Loa (eye worm) zinc metallopeptidase 4 0.0024 0.0027 0.008
Schistosoma mansoni casein kinase II beta subunit 0.0038 0.0068 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0118 0.0301 0.1179
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0401 0.1129 0.1128
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0335 0.0935 0.2811
Onchocerca volvulus 0.01 0.0249 0.2661
Schistosoma mansoni kinase 0.0103 0.0257 0.0685
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0401 0.1129 0.3286
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0064 0.0142 0.0401
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0015 0.0015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0089 0.0217 0.0889
Loa Loa (eye worm) hypothetical protein 0.0099 0.0245 0.0736
Loa Loa (eye worm) hypothetical protein 0.0075 0.0175 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.0406 0.1143 0.465
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0015 0.0039
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0066 0.0175
Echinococcus multilocularis voltage dependent calcium channel 0.0033 0.0054 0.0054
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0089 0.0217 0.4285
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0142 0.0525
Brugia malayi Casein kinase II, alpha chain 0.0143 0.0374 0.153
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0258 0.0711 0.5637
Echinococcus granulosus serine:threonine protein kinase PLK1 0.02 0.0541 0.054
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.0305 0.1197
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0068 0.0219
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0007 0.0019
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0364 0.0969
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0288 0.0865
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0046 0.0639
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0408 0.1149 0.4673
Giardia lamblia Kinase, CMGC CK2 0.0143 0.0374 0.251
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0064 0.0142 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.106 0.4304
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0414 0.1165 0.932
Echinococcus granulosus expressed protein 0.0389 0.1094 0.1094
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0028 0.0038 0.0098
Loa Loa (eye worm) hypothetical protein 0.0075 0.0175 0.0525
Echinococcus granulosus intermediate filament protein 0.0028 0.0038 0.0038
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1301 0.3757 0.3757
Mycobacterium leprae probable zinc metalloprotease 0.0099 0.0245 0.8431
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0142 0.0525
Schistosoma mansoni hypothetical protein 0.01 0.0249 0.0662
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0182 0.0489 0.0489
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0053 0.0112 0.0336
Brugia malayi 6-phosphofructokinase 0.0113 0.0288 0.1178
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0043 0.0083 0.0228
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0182 0.0489 0.42
Loa Loa (eye worm) hypothetical protein 0.017 0.0454 0.1364
Echinococcus granulosus cyclin dependent kinase 19 0.014 0.0364 0.0364
Echinococcus multilocularis high voltage activated calcium channel beta 0.009 0.0221 0.022
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0846 0.2428 0.2427
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0089 0.0217 0.4253
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0335 0.0935 0.0935
Trichomonas vaginalis PIKK family atypical protein kinase 0.0377 0.1059 0.4303
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0 0.0001
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.033 0.092 0.3728
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0374 0.1479
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0046 0.0128
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0047 0.0123
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0374 0.1479
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0442 0.1249 0.1249
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0186 0.0501 0.1506
Trichomonas vaginalis conserved hypothetical protein 0.0229 0.0626 0.252
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0033 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0073 0.017 0.051
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0089 0.0217 0.062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0349 0.0975 0.3958
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0064 0.0142 0.0525
Giardia lamblia GTOR 0.0442 0.1249 0.9211
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0401 0.1129 0.4622
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.033 0.092 0.2674
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0033 0.0054 0.0221
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0182 0.0489 0.0489
Loa Loa (eye worm) hypothetical protein 0.0033 0.0054 0.0162
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.036 0.1008 0.8049
Loa Loa (eye worm) hypothetical protein 0.0105 0.0263 0.0789
Giardia lamblia Hypothetical protein 0.0089 0.0217 0.1311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0406 0.1143 0.465
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0046 0.0268
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0851 0.2442 1
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0015 0.0015
Brugia malayi PAS domain containing protein 0.0051 0.0105 0.0428
Echinococcus granulosus lamin dm0 0.0028 0.0038 0.0038
Echinococcus multilocularis protein kinase shaggy 0.0053 0.0112 0.0112
Entamoeba histolytica casein kinase, putative 0.0143 0.0374 0.1479
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0478 0.1352 1
Schistosoma mansoni hypothetical protein 0.0175 0.0468 0.1246
Brugia malayi Serotonin receptor 0.0486 0.1378 0.5642
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0047 0.0123
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0182 0.0489 0.42
Echinococcus multilocularis geminin 0.0175 0.0468 0.0468
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0288 0.1124
Loa Loa (eye worm) hypothetical protein 0.0491 0.1391 0.4182
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0603 0.1718 0.1718
Trichomonas vaginalis CAMK family protein kinase 0.02 0.0541 0.2166
Echinococcus granulosus beta-adrenergic receptor kinase 0.0024 0.0025 0.0025
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0043 0.0083 0.0281
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0142 0.0525
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.022 0.0599 0.2406
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0209 0.0566 0.0566
Brugia malayi Csnk2b protein 0.0038 0.0068 0.0278
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0068 0.0219
Brugia malayi hypothetical protein 0.017 0.0454 0.1858
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0288 0.1124
Loa Loa (eye worm) phosphatidylinositol 3 0.0089 0.0217 0.0653
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0038 0.0068 0.0219
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0181 0.0485 0.0485
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.0288 0.0287
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0068 0.0219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0406 0.1143 0.465
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0109
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0142 0.0525
Leishmania major casein kinase II, putative 0.0143 0.0374 0.1001
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0015 0.0015
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0142 0.0525
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0089 0.0217 0.0833
Schistosoma mansoni endothelin-converting enzyme-related 0.0024 0.0027 0.007
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0038 0.0114
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0142 0.0525
Echinococcus granulosus tumor protein p63 0.0352 0.0986 0.0986
Loa Loa (eye worm) hypothetical protein 0.0075 0.0175 0.0525
Loa Loa (eye worm) hypothetical protein 0.0052 0.0107 0.0322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.0839 0.3397
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0064 0.0142 0.0525
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0288 0.1124
Brugia malayi hypothetical protein 0.002 0.0015 0.0061
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0015 0.003
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0046 0.069
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0093 0.0228 0.0606
Onchocerca volvulus 0.0028 0.0038 0.0402
Trichomonas vaginalis CAMK family protein kinase 0.02 0.0541 0.2166
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0047 0.0141
Onchocerca volvulus 0.0038 0.0066 0.0705
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0047 0.0046
Plasmodium vivax SET domain protein, putative 0.0031 0.0047 0.0653
Plasmodium vivax glycogen synthase kinase 3, putative 0.0053 0.0112 0.2029
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0266 0.0734 0.2963
Loa Loa (eye worm) gastrulation defective protein 1 0.0136 0.0354 0.1063
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0028 0.0038 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0266 0.0734 0.2963
Toxoplasma gondii CMGC kinase, CK2 family 0.0143 0.0374 0.3175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0385 0.1081 0.4392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0224 0.0611 0.2455
Brugia malayi Cytochrome P450 family protein 0.002 0.0015 0.0063
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0089 0.0217 0.0217
Mycobacterium tuberculosis Conserved hypothetical protein 0.0089 0.0217 0.7406
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0377 0.1058 0.4298
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0089 0.0217 0.062
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0625 0.1782 0.7281
Schistosoma mansoni hypothetical protein 0.0026 0.0032 0.0084
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0044
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0182 0.0489 0.1955
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0038 0.0068 0.0219
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.0112 0.0399
Leishmania major phosphatidylinositol 3-kinase, putative 0.0182 0.0489 0.1315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.0217 0.0833
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0288 0.1124
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0053 0.0112 0.0289
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0025 0.0066
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0135 0.035 0.1008
Mycobacterium ulcerans putative regulatory protein 0.002 0.0016 0.0007
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0442 0.1249 1
Echinococcus multilocularis serine protein kinase ATM 0.0224 0.0611 0.061
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.02 0.0541 0.1455
Loa Loa (eye worm) phosphatidylinositol 3 0.024 0.0659 0.1981
Leishmania major phosphatidylinositol kinase, putative 0.0089 0.0217 0.0576
Trichomonas vaginalis CAMK family protein kinase 0.02 0.0541 0.2166
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0046 0.0128
Echinococcus multilocularis expressed protein 0.0389 0.1094 0.1094
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0442 0.1249 0.3637
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.106 0.4304
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0182 0.0489 1
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0288 0.0765
Entamoeba histolytica hypothetical protein 0.0038 0.0066 0.0211
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0068 0.0219
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0068 0.0219
Brugia malayi phosphofructokinase 0.0113 0.0288 0.1178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0413 0.1165 0.4737
Entamoeba histolytica serine/threonine protein kinase, putative 0.02 0.0541 0.2166
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.045 0.1271 0.5207
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0028 0.0038 0.0098
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0288 0.1124
Loa Loa (eye worm) hypothetical protein 0.0135 0.035 0.1052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0413 0.1165 0.4737
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0068 0.0219
Echinococcus granulosus axis inhibition protein axin 0.002 0.0015 0.0015
Loa Loa (eye worm) peptidase family M13 containing protein 0.0073 0.017 0.051
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0119 0.0431
Schistosoma mansoni neprilysin 0.0026 0.0032 0.0084
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1301 0.3757 0.3757
Loa Loa (eye worm) phosphatidylinositol 3 0.0089 0.0217 0.0653
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.0288 0.0767
Toxoplasma gondii hypothetical protein 0.0056 0.0119 0.0921
Brugia malayi Protein kinase domain containing protein 0.0019 0.001 0.0043
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0142 0.0525
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0019 0.0057
Schistosoma mansoni Nep2 peptidase (M13 family) 0.005 0.0102 0.0271
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.024 0.0659 0.1912
Trichomonas vaginalis set domain proteins, putative 0.0245 0.0672 0.2707
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0033 0.0054 0.0143
Trypanosoma cruzi target of rapamycin kinase 3 0.0414 0.1165 0.3392
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0026 0.0032 0.0084
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0089 0.0217 0.1635
Echinococcus granulosus casein kinase ii subunit alpha 0.0143 0.0374 0.0374
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0028 0.0038 0.0038
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0038 0.0068 0.0219
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0015 0.0015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0605 0.1725 0.7063
Echinococcus multilocularis musashi 0.0028 0.0038 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0406 0.1143 0.465
Toxoplasma gondii ck2 beta subunit 0.0038 0.0068 0.0465
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0024 0.0027 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0442 0.1249 0.5084
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.0599 0.2406
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0414 0.1165 0.3151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0266 0.0734 0.2963
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0033 0.0054 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0377 0.1059 0.4303
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.106 0.4304
Trypanosoma brucei Casein kinase II 0.0143 0.0374 0.2905
Brugia malayi Death domain containing protein 0.0015 0 0.0001
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0224 0.0611 0.1771
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0181 0.0485 0.0485
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0046 0.0128
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0023
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.0288 0.0287
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0182 0.0489 0.1416
Brugia malayi M-phase phosphoprotein, mpp8 0.0105 0.0262 0.1074
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0043 0.0043
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0015 0.0046
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0703 0.2012 0.8227
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0033 0.0054 0.0054
Entamoeba histolytica hypothetical protein 0.0089 0.0217 0.0833
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.0585 0.1758
Giardia lamblia Casein kinase II beta chain 0.0038 0.0068 0.017
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0089 0.0217 0.062
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0028 0.0038 0.0158
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0025 0.0066
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0851 0.2442 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.0249 0.102
Trypanosoma cruzi polo-like protein kinase, putative 0.02 0.0541 0.1566
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0247 0.0677 0.2034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0273 0.0755 0.305
Leishmania major phosphatidylinositol 4-kinase, putative 0.0089 0.0217 0.0576
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0186 0.0501 0.2052
Schistosoma mansoni hypothetical protein 0.017 0.0454 0.1209
Onchocerca volvulus 0.0089 0.0217 0.2319
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0142 0.0525
Entamoeba histolytica hypothetical protein 0.0089 0.0217 0.0833
Schistosoma mansoni intermediate filament proteins 0.0028 0.0038 0.01
Giardia lamblia Kinase, CMGC GSK 0.0053 0.0112 0.0504
Trichomonas vaginalis PIKK family atypical protein kinase 0.0377 0.1059 0.4303
Onchocerca volvulus 0.0053 0.0112 0.1193
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0015 0.0015
Echinococcus multilocularis casein kinase ii subunit alpha 0.0143 0.0374 0.0374
Brugia malayi SH2 domain containing protein 0.071 0.2031 0.8318
Loa Loa (eye worm) peptidase family M13 containing protein 0.0073 0.017 0.051
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0066 0.0066
Trichomonas vaginalis CAMK family protein kinase 0.02 0.0541 0.2166
Leishmania major phosphatidylinositol 3-related kinase, putative 0.036 0.1008 0.2725
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0028 0.0038 0.0158
Echinococcus multilocularis voltage dependent calcium channel 0.0033 0.0054 0.0054
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0224 0.0611 0.1625
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0851 0.2442 0.7127
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.02 0.0541 0.054
Schistosoma mansoni hypothetical protein 0.0089 0.0217 0.0577
Giardia lamblia Phosphatidylinositol 4-kinase 0.0089 0.0217 0.1311
Schistosoma mansoni regulator of G protein signaling 0.002 0.0015 0.0039
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.0112 0.0399
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0089 0.0217 0.0217
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0066 0.1861
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0182 0.0489 0.0489
Entamoeba histolytica hypothetical protein 0.0703 0.2012 0.8227
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0374 0.1479
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0046 0.0128
Schistosoma mansoni hypothetical protein 0.0026 0.0032 0.0084
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0068 0.0219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0406 0.1143 0.465
Loa Loa (eye worm) hypothetical protein 0.0209 0.0566 0.1701
Trichomonas vaginalis CAMK family protein kinase 0.02 0.0541 0.2166
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0021 0.0085
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0209 0.0566 0.164
Brugia malayi PXA domain containing protein 0.0021 0.0019 0.0078
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0288 0.2207
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1301 0.3757 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0104 0.0262 0.075
Schistosoma mansoni lamin 0.0028 0.0038 0.01
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0064 0.0142 0.0401
Loa Loa (eye worm) hypothetical protein 0.0099 0.0245 0.0736
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.014 0.0366 0.0366
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0142 0.0525
Mycobacterium leprae conserved hypothetical protein 0.0089 0.0217 0.7406
Echinococcus multilocularis 0.0089 0.0217 0.0217
Trichomonas vaginalis CAMK family protein kinase 0.02 0.0541 0.2166
Trypanosoma brucei protein kinase, putative 0.0053 0.0112 0.0781
Brugia malayi FAT domain containing protein 0.014 0.0366 0.1498
Toxoplasma gondii peptidase family M13 protein 0.0099 0.0245 0.2034
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0066 0.0066
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0093 0.0228 0.0606
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0147 0.0385 0.2997
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0066 0.0066
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0335 0.0935 0.383
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0053 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0002
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0064 0.0142 0.0525
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0025 0.0066
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0046 0.069
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0089 0.0217 0.0833
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0068 0.0219
Loa Loa (eye worm) RGS-3 protein 0.002 0.0015 0.0044
Leishmania major phosphatidylinositol kinase related protein, putative 0.0104 0.0262 0.0697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0209 0.0566 0.2271
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0028 0.0038 0.0038
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0182 0.0489 0.1302
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0379 0.1065 0.2834
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0182 0.0489 0.1416
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0107 0.0285
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0182 0.0489 0.3842
Trichomonas vaginalis PIKK family atypical protein kinase 0.0406 0.1143 0.465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0349 0.0975 0.3958
Loa Loa (eye worm) hypothetical protein 0.0105 0.0262 0.0788
Echinococcus multilocularis lamin 0.0028 0.0038 0.0038
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0182 0.0489 0.1471
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0209 0.0566 0.2318
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0015 0.0061
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0064 0.0142 0.0378
Brugia malayi Cytochrome P450 family protein 0.002 0.0015 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0413 0.1165 0.4737
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0224 0.0611 0.25
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.1187 0.3424 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0046 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0119 0.0431
Brugia malayi peptidase family M13 containing protein 0.0024 0.0027 0.0109
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0112 0.0399
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0015 0.0015
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.009 0.0221 0.0587
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0024 0.0025 0.0075
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0064 0.0142 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.036 0.1008 0.4092
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0089 0.0217 0.0577
Loa Loa (eye worm) hypothetical protein 0.0031 0.0047 0.014
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0089 0.0217 0.4285
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0 0.0001
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0015 0.0039
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0089 0.0217 0.1786
Echinococcus multilocularis lamin dm0 0.0028 0.0038 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0442 0.1249 0.5084
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0015 0.0039
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0142 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.0406 0.1143 0.465
Loa Loa (eye worm) hypothetical protein 0.0073 0.017 0.051
Loa Loa (eye worm) hypothetical protein 0.0099 0.0245 0.0736
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0046 0.0268
Loa Loa (eye worm) hypoxia-induced factor 1 0.0157 0.0415 0.1248
Schistosoma mansoni survival motor neuron protein 0.01 0.0249 0.0662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0349 0.0975 0.3958
Brugia malayi PXA domain containing protein 0.0021 0.0019 0.0078
Brugia malayi hypothetical protein 0.0038 0.0066 0.027
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.005 0.0102 0.0271
Schistosoma mansoni hypothetical protein 0.0053 0.0113 0.0299
Echinococcus granulosus axis inhibition protein axin 0.002 0.0015 0.0015
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0064 0.0142 0.0525
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0053 0.0112 0.0311
Echinococcus granulosus bloom syndrome protein 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0229 0.0626 0.1883
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0089 0.0217 0.0217
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.0288 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.0027 0.007
Loa Loa (eye worm) hypothetical protein 0.0089 0.0217 0.0653
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0114
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0288 0.0865
Trichomonas vaginalis PIKK family atypical protein kinase 0.0385 0.1081 0.4392
Brugia malayi intermediate filament protein 0.0028 0.0038 0.0155
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0442 0.1249 0.5084
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0089 0.0217 0.0889
Onchocerca volvulus 0.0028 0.0038 0.0402
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0038 0.0068 0.0184
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0182 0.0489 0.1302
Schistosoma mansoni axis inhibition protein axin 0.002 0.0015 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0366 0.1446
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0047
Schistosoma mansoni hypothetical protein 0.0038 0.0066 0.0175
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0015 0.0061
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0064 0.0142 0.0525
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0015 0.0015
Leishmania major phosphatidylinositol 3-kinase, putative 0.0349 0.0975 0.2636
Loa Loa (eye worm) CYP4Cod1 0.002 0.0015 0.0046
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0033 0.0054 0.0054
Loa Loa (eye worm) phosphofructokinase 0.0113 0.0288 0.0865
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0112 0.0399
Schistosoma mansoni hypothetical protein 0.0175 0.0468 0.1246
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.014 0.0366 0.0366
Onchocerca volvulus 0.0245 0.0672 0.7186
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0335 0.0935 1
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0038 0.0068 0.0171
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0015 0.0039
Echinococcus granulosus survival motor neuron protein 1 0.0491 0.1391 0.1391
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0442 0.1249 0.3637
Brugia malayi Protein kinase domain containing protein 0.0335 0.0935 0.383
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0442 0.1249 0.3379
Brugia malayi hypoxia-induced factor 1 0.0157 0.0415 0.17
Echinococcus granulosus voltage dependent calcium channel 0.0033 0.0054 0.0054
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.033 0.092 0.3728
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0015 0.0015
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0099 0.0245 0.8431
Giardia lamblia Kinase, PLK 0.02 0.0541 0.3788
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0064 0.0142 0.0525
Echinococcus multilocularis tumor protein p63 0.0352 0.0986 0.0986

Activities

Activity type Activity value Assay description Source Reference
k cat (binding) = 2.65 min-1 Catalysis kinetic constant was measured for the hydrolysis of the compound catalyzed by antibody 15C5 ChEMBL. No reference
Km (binding) = 87 uM Michaelis-Menten kinetics was measured for the hydrolysis of the compound catalyzed by antibody 15C5 ChEMBL. No reference
Kuncat (binding) = 2.1 min-1 Hydrolysis kinetic catalysis constant was measured for the hydrolysis of the compound catalyzed by antibody 15C5 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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