Detailed information for compound 560815

Basic information

Technical information
  • TDR Targets ID: 560815
  • Name: N,N'-bis[(3-hydroxy-4-methoxy-phenyl)methylen eamino]decanediamide
  • MW: 498.571 | Formula: C26H34N4O6
  • H donors: 4 H acceptors: 4 LogP: 4.1 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1O)C=NNC(=O)CCCCCCCCC(=O)N/N=C/c1ccc(c(c1)O)OC
  • InChi: 1S/C26H34N4O6/c1-35-23-13-11-19(15-21(23)31)17-27-29-25(33)9-7-5-3-4-6-8-10-26(34)30-28-18-20-12-14-24(36-2)22(32)16-20/h11-18,31-32H,3-10H2,1-2H3,(H,29,33)(H,30,34)
  • InChiKey: RRPHDRBVRDPBGV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,N'-bis[(3-hydroxy-4-methoxyphenyl)methyleneamino]decanediamide
  • N,N'-bis[(3-hydroxy-4-methoxy-phenyl)methylideneamino]decanediamide
  • N,N'-bis[(3-hydroxy-4-methoxy-benzylidene)amino]sebacamide
  • N,N'-bis[(3-hydroxy-4-methoxyphenyl)methylideneamino]decanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0168 0.387 1
Schistosoma mansoni lipoxygenase 0.0121 0.2726 0.7045
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0029 0.0457 0.0799
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0243 0.0111
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.7194 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0029 0.0457 0.0799
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.0387 0.0999
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.5049 0.4955
Brugia malayi hypothetical protein 0.0026 0.0387 0.0348
Loa Loa (eye worm) hypothetical protein 0.0154 0.3526 0.3404
Loa Loa (eye worm) cytochrome P450 family protein 0.0107 0.2376 0.2232
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0243 0.2206
Echinococcus multilocularis sodium and chloride dependent glycine 0.0026 0.0387 0.0502
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0026 0.0387 0.0502
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0505 0.1306
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0387 0.0999
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0246 0.0143
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0026 0.0387 0.0205
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0026 0.0387 0.0205
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0026 0.0387 0.0502
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0029 0.0457 0.0842
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0029 0.0457 0.0799
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0029 0.0457 0.0799
Echinococcus multilocularis bloom syndrome protein 0.002 0.0246 0.0118
Loa Loa (eye worm) hypothetical protein 0.0031 0.0505 0.0326
Echinococcus multilocularis p2X purinoceptor 4 0.007 0.1461 0.3431
Schistosoma mansoni sodium/chloride dependent transporter 0.0026 0.0387 0.0999
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0387 0.0348
Loa Loa (eye worm) inositol-1 0.0037 0.0644 0.0467
Echinococcus granulosus p2X purinoceptor 4 0.007 0.1461 0.3431
Loa Loa (eye worm) RecQ helicase 0.002 0.0246 0.0061
Brugia malayi Inositol-1 0.0037 0.0644 0.0833
Schistosoma mansoni DNA helicase recq1 0.002 0.0246 0.0635
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0029 0.0457 0.0799
Schistosoma mansoni inositol monophosphatase 0.0037 0.0644 0.1664
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0029 0.0457 0.0799
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0142 0.3222 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0644 0.1462
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0026 0.0387 0.0502
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0029 0.0457 0.0799
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0029 0.0457 0.0799
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0644 0.1462
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0243 0.0111
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0047 0.0897 0.2185
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0243 0.0111
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.0387 0.0999
Schistosoma mansoni rab6-interacting 0.002 0.0243 0.0628
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0029 0.0457 0.0799
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0029 0.0457 0.0799
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0029 0.0457 0.0799
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0029 0.0457 0.0799
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.0387 0.6004
Leishmania major cytochrome p450-like protein 0.0029 0.0457 0.0842
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0897 0.2301
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0243 0.0111
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0246 0.0062
Trypanosoma brucei Emopamil binding protein, putative 0.0142 0.3222 1
Loa Loa (eye worm) CYP4Cod1 0.0047 0.0897 0.0726
Echinococcus multilocularis geminin 0.0168 0.387 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0029 0.0457 0.0842
Loa Loa (eye worm) hypothetical protein 0.0418 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0243 0.0059
Echinococcus granulosus geminin 0.0168 0.387 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0246 0.0143
Leishmania major cytochrome p450-like protein 0.0047 0.0897 0.2301
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0026 0.0387 0.0502
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0029 0.0457 0.0799
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0387 0.7648
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0505 0.0826
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0246 0.0062
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0505 0.785
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0029 0.0457 0.0799
Brugia malayi Cytochrome P450 family protein 0.0029 0.0457 0.048
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0243 0.0111
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0644 0.1462
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0246 0.2346
Schistosoma mansoni sodium/chloride dependent transporter 0.0026 0.0387 0.0999
Echinococcus granulosus sodium and chloride dependent glycine 0.0026 0.0387 0.0502
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0121 0.2726 0.6882
Echinococcus granulosus p2X purinoceptor 4 0.007 0.1461 0.3431
Brugia malayi Cytochrome P450 family protein 0.0047 0.0897 0.1312
Schistosoma mansoni polycystin 1-related 0.002 0.0243 0.0628
Plasmodium falciparum transporter, putative 0.0026 0.0387 1
Echinococcus multilocularis 0.0029 0.0457 0.0693
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0121 0.2726 0.6882
Loa Loa (eye worm) hypothetical protein 0.0026 0.0387 0.0205
Onchocerca volvulus 0.0026 0.0387 0.0259
Onchocerca volvulus 0.0154 0.3526 0.5928
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0029 0.0457 0.0799
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0457 0.0842
Plasmodium falciparum amino acid transporter, putative 0.0026 0.0387 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0029 0.0457 0.0799
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0246 0.3816
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0644 0.0631
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0029 0.0457 0.0799
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0246 0.2346
Echinococcus granulosus sodium and chloride dependent glycine 0.0026 0.0387 0.0502
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0029 0.0457 0.0799
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0246 0.0082
Schistosoma mansoni P2X receptor subunit 0.007 0.1461 0.3774
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0026 0.0387 0.0502
Toxoplasma gondii hypothetical protein 0.0026 0.0387 0.6004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0387 0.0205
Echinococcus granulosus cytochrome P450 2K1 0.0029 0.0457 0.0693
Loa Loa (eye worm) hypothetical protein 0.0154 0.3526 0.3404
Brugia malayi Pre-SET motif family protein 0.0031 0.0505 0.0572
Onchocerca volvulus 0.0246 0.5782 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0505 0.1306
Echinococcus multilocularis serotonin transporter 0.0154 0.3526 0.9063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.7194 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.0387 0.6004
Onchocerca volvulus 0.0026 0.0387 0.0259
Schistosoma mansoni ap endonuclease 0.0019 0.0202 0.0523
Schistosoma mansoni P2X receptor subunit 0.007 0.1461 0.3774
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0029 0.0457 0.0799
Treponema pallidum fructose-bisphosphate aldolase 0.0303 0.7194 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0029 0.0457 0.0799
Toxoplasma gondii hypothetical protein 0.0026 0.0387 0.6004
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0387 0.0999
Trypanosoma cruzi Emopamil binding protein, putative 0.0142 0.3222 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0387 0.0205
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0387 0.0999
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0029 0.0457 0.0799
Echinococcus granulosus bloom syndrome protein 0.002 0.0246 0.0118
Leishmania major cytochrome p450-like protein 0.0029 0.0457 0.0842
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.7194 1
Loa Loa (eye worm) cytochrome P450 0.0029 0.0457 0.0276
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0202 0.0017
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0029 0.0457 0.0799
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0029 0.0457 0.0799
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.3383 1
Plasmodium vivax amine transporter, putative 0.0026 0.0387 0.7648
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0029 0.0457 0.0799
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0644 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0457 0.0842
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0644 0.1203
Toxoplasma gondii exonuclease III APE 0.0019 0.0202 0.3145
Loa Loa (eye worm) solute carrier family 6 member 4 0.0154 0.3526 0.3404
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0202 0.0281
Schistosoma mansoni rab6-interacting 0.002 0.0243 0.0628
Loa Loa (eye worm) hypothetical protein 0.0026 0.0387 0.0205
Loa Loa (eye worm) hypothetical protein 0.002 0.0246 0.0061
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0026 0.0387 0.0999
Onchocerca volvulus 0.0026 0.0387 0.0259
Entamoeba histolytica recQ family helicase, putative 0.002 0.0246 0.0342
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0246 0.0082
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0243 0.0111
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0387 0.0348
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0029 0.0457 0.0799
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0029 0.0457 0.0799
Echinococcus multilocularis p2X purinoceptor 4 0.007 0.1461 0.3431
Giardia lamblia Fructose-bisphosphate aldolase 0.0303 0.7194 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0243 0.0059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.7194 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.7194 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0026 0.0387 0.0999
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0246 0.0082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.7194 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0505 0.1306
Brugia malayi hypothetical protein 0.002 0.0243 0.0077
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0029 0.0457 0.0799
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.5499 0.5414
Loa Loa (eye worm) hypothetical protein 0.0026 0.0387 0.0205
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0644 0.1203
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.7194 1
Echinococcus granulosus serotonin transporter 0.0154 0.3526 0.9063
Trypanosoma cruzi Emopamil binding protein, putative 0.0142 0.3222 1
Schistosoma mansoni hypothetical protein 0.002 0.0243 0.0628
Loa Loa (eye worm) hypothetical protein 0.0154 0.3526 0.3404
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0029 0.0457 0.0799
Onchocerca volvulus 0.0142 0.3222 0.5379
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.7194 1
Loa Loa (eye worm) serotonin transporter b 0.0154 0.3526 0.3404
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0154 0.3526 0.9112
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0246 0.0062
Treponema pallidum sodium- and chloride- dependent transporter 0.0154 0.3526 0.4754
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0387 0.0348
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0026 0.0387 0.0999
Onchocerca volvulus 0.0031 0.0505 0.0474
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0246 0.0062
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0246 0.3816
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0505 0.1306
Schistosoma mansoni ap endonuclease 0.0019 0.0202 0.0523
Schistosoma mansoni sodium/chloride dependent transporter 0.0154 0.3526 0.9112
Echinococcus granulosus RUN 0.002 0.0243 0.0111
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.7194 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0029 0.0457 0.0799
Brugia malayi Doublecortin family protein 0.002 0.0243 0.0077
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0029 0.0457 0.0799
Echinococcus granulosus p2X purinoceptor 4 0.007 0.1461 0.3431
Echinococcus multilocularis p2X purinoceptor 4 0.007 0.1461 0.3431
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0897 0.0726
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0897 0.0726
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0142 0.3222 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0387 0.0205
Echinococcus multilocularis RUN 0.002 0.0243 0.0111
Brugia malayi Pre-SET motif family protein 0.0216 0.5049 0.915
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0029 0.0457 0.0842
Schistosoma mansoni P2X receptor subunit 0.007 0.1461 0.3774
Leishmania major hypothetical protein, conserved 0.0142 0.3222 1
Schistosoma mansoni hypothetical protein 0.0168 0.387 1
Schistosoma mansoni hypothetical protein 0.0029 0.0457 0.118
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0246 0.0118
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.3383 1
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0897 0.2301
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0142 0.3222 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.055 0.0317
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0029 0.0457 0.0799
Plasmodium vivax SET domain protein, putative 0.0031 0.0505 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0644 0.1664
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0246 0.0061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.7194 1
Brugia malayi follicle stimulating hormone receptor 0.0234 0.5499 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0026 0.0387 0.0502
Brugia malayi Cytochrome P450 family protein 0.0107 0.2376 0.4104
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.0387 0.6004
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0246 0.0143
Schistosoma mansoni loxhd1 0.002 0.0243 0.0628
Schistosoma mansoni cytochrome P450 0.0029 0.0457 0.118
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0029 0.0457 0.0799
Loa Loa (eye worm) doublecortin family protein 0.002 0.0243 0.0059
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0154 0.3526 0.6275
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0246 0.0118
Trypanosoma brucei cytochrome P450, putative 0.0047 0.0897 0.2301
Schistosoma mansoni P2X receptor subunit 0.007 0.1461 0.3774
Toxoplasma gondii cytochrome p450 superfamily protein 0.0029 0.0457 0.7094
Trichomonas vaginalis set domain proteins, putative 0.0246 0.5782 0.798
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0029 0.0457 0.0799
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0026 0.0387 0.0502
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.055 0.1091
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.3383 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0029 0.0457 0.0799
Brugia malayi Cytochrome P450 family protein 0.0047 0.0897 0.1312
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.0387 0.0999
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0029 0.0457 0.0799
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0243 0.4809
Loa Loa (eye worm) hypothetical protein 0.0026 0.0387 0.0205
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0029 0.0457 0.0799
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0202 0.4006
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0246 0.0118
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0026 0.0387 0.0348
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0644 0.0631
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0029 0.0457 0.0799
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0026 0.0387 0.5
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0029 0.0457 0.0799
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0644 0.1462
Brugia malayi hypothetical protein 0.002 0.0243 0.0077
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0505 0.0826
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0644 0.1387
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0644 0.0631
Schistosoma mansoni DNA helicase recq5 0.002 0.0246 0.0635
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0505 0.0826
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0026 0.0387 0.0502
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0029 0.0457 0.0799
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0477 0.075
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0029 0.0457 0.0799
Brugia malayi cytochrome P450 0.0029 0.0457 0.048
Loa Loa (eye worm) norepinephrine transporter 0.0154 0.3526 0.3404
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0644 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0644 0.0895
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0246 0.0118
Schistosoma mansoni lipoxygenase 0.0085 0.1829 0.4726

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

105 literature references were collected for this gene.

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