Detailed information for compound 572996

Basic information

Technical information
  • TDR Targets ID: 572996
  • Name: 2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)ph enyl]propanoic acid
  • MW: 525.077 | Formula: C15H13I2NO4
  • H donors: 3 H acceptors: 3 LogP: 1.06 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(Cc1ccc(cc1)Oc1cc(I)c(c(c1)I)O)N
  • InChi: 1S/C15H13I2NO4/c16-11-6-10(7-12(17)14(11)19)22-9-3-1-8(2-4-9)5-13(18)15(20)21/h1-4,6-7,13,19H,5,18H2,(H,20,21)
  • InChiKey: LROTZSUGDZPWDN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)phenyl]propanoic acid
  • 2-azanyl-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)phenyl]propanoic acid
  • 2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)phenyl]propionic acid
  • 3',5'-diiodothyronine
  • 60363-25-9
  • DL-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-
  • EINECS 262-198-7
  • O-(4-Hydroxy-3,5-diiodophenyl)-DL-tyrosine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0011 0.0076 0.0112
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0039 0.0635
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0855 0.0819
Schistosoma mansoni hypothetical protein 0.001 0.0065 0.0066
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0057 0.0617 0.0607
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0514 0.0513
Brugia malayi Cation transporter family protein 0.0254 0.2936 0.3444
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0065 0.0066
Loa Loa (eye worm) hypothetical protein 0.0122 0.1379 0.1381
Loa Loa (eye worm) hypothetical protein 0.0254 0.2936 0.2943
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0011 0.0076 0.0112
Brugia malayi Dopamine receptor protein 2 0.001 0.0065 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0196 0.3177
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0011 0.0076 0.1231
Brugia malayi hypothetical protein 0.0122 0.1379 0.1616
Loa Loa (eye worm) hypothetical protein 0.0122 0.1379 0.1381
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0011 0.0076 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0057 0.0617 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0011 0.0076 0.0073
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0514 0.1202
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0643 0.1528
Onchocerca volvulus 0.0031 0.0308 0.0929
Schistosoma mansoni ferritin 0.0009 0.0047 0.0021
Brugia malayi G protein-coupled receptor 0.001 0.0065 0.0073
Onchocerca volvulus 0.0254 0.2936 1
Mycobacterium leprae conserved hypothetical protein 0.0011 0.0076 0.1366
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0065 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0065 0.0028
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0065 0.0028
Echinococcus multilocularis SAM domain containing protein 0.0018 0.0163 0.0125
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.0161
Echinococcus multilocularis neuropeptide receptor 0.001 0.0065 0.0026
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0065 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0065 0.0066
Loa Loa (eye worm) hypothetical protein 0.0254 0.2936 0.2943
Entamoeba histolytica hypothetical protein 0.0077 0.0855 0.5568
Brugia malayi Tnks protein 0.0207 0.2381 0.2793
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0011 0.0076 0.0251
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.0065 0.0066
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0254 0.2936 0.3444
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.0076 0.0073
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0065 0.0028
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0011 0.0076 0.0112
Brugia malayi Dopamine receptor protein 1 0.001 0.0065 0.0073
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0032 0.0325 0.1951
Echinococcus granulosus glycine receptor subunit beta 0.0254 0.2936 0.3041
Toxoplasma gondii ATPase, AAA family protein 0.0031 0.0308 0.4352
Echinococcus granulosus geminin 0.0343 0.399 0.4148
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.0065 0.0066
Onchocerca volvulus 0.001 0.0065 0.009
Echinococcus granulosus SAM domain containing protein 0.0018 0.0163 0.013
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.0065 0.0063
Trichomonas vaginalis ferritin, putative 0.0009 0.0047 0.0767
Schistosoma mansoni hypothetical protein 0.0018 0.0163 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Loa Loa (eye worm) hypothetical protein 0.0254 0.2936 0.2943
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0254 0.2936 0.7332
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.0065 0.0028
Brugia malayi gonadotropin-releasing hormone receptor 2 0.001 0.0065 0.0073
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0057 0.0617 0.1766
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0132 0.1504 0.1762
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0132 0.1504 0.1762
Onchocerca volvulus 0.0254 0.2936 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.0065 0.0066
Onchocerca volvulus 0.0122 0.1379 0.4625
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0308 0.4996
Brugia malayi DKFZp564C0469 protein 0.0031 0.0308 0.0359
Onchocerca volvulus 0.001 0.0065 0.009
Echinococcus multilocularis glycine receptor subunit beta 0.0254 0.2936 0.2908
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0031 0.0308 0.4996
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.0065 0.0028
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0254 0.2936 0.2908
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Schistosoma mansoni hypothetical protein 0.0077 0.0855 0.2064
Loa Loa (eye worm) hypothetical protein 0.0008 0.0039 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.0065 0.0026
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0011 0.0076 0.0093
Loa Loa (eye worm) hypothetical protein 0.0122 0.1379 0.1381
Entamoeba histolytica hypothetical protein 0.0031 0.0308 0.1837
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0163 0.0202
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0065 0.0066
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Echinococcus multilocularis nibrin 0.0031 0.0308 0.027
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.003 0.0296 0.0258
Loa Loa (eye worm) ACC-1 protein 0.0254 0.2936 0.2943
Echinococcus multilocularis liprin alpha 2 0.0018 0.0163 0.0125
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0048 0.0022
Echinococcus multilocularis Smad4 0.0009 0.0048 0.0009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0039 0.0037
Plasmodium falciparum tyrosine kinase-like protein 0.0018 0.0163 0.4615
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0132 0.1504 0.1506
Echinococcus multilocularis stromal interaction molecule 1 0.0018 0.0163 0.0125
Onchocerca volvulus 0.001 0.0065 0.009
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0057 0.0617 0.1699
Brugia malayi hypothetical protein 0.0031 0.0308 0.0359
Entamoeba histolytica hypothetical protein 0.0011 0.0076 0.0251
Onchocerca volvulus 0.001 0.0065 0.009
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Schistosoma mansoni opsin-like receptor 0.001 0.0065 0.0066
Loa Loa (eye worm) hypothetical protein 0.0122 0.1379 0.1381
Entamoeba histolytica hypothetical protein 0.0011 0.0076 0.0251
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0065 0.0028
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0011 0.0076 0.0086
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0018 0.0163 0.0189
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0011 0.0076 0.0112
Entamoeba histolytica hypothetical protein 0.0011 0.0076 0.0251
Brugia malayi hypothetical protein 0.001 0.0065 0.0073
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0011 0.0076 0.0039
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0011 0.0076 0.006
Echinococcus granulosus neuropeptide receptor 0.001 0.0065 0.0028
Brugia malayi Serotonin receptor 0.001 0.0065 0.0073
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0325 0.0378
Onchocerca volvulus 0.0011 0.0076 0.0127
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0254 0.2936 0.7332
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0254 0.2936 0.3444
Schistosoma mansoni ferritin 0.0009 0.0047 0.0021
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0122 0.1379 0.1616
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0005 0 0.0006
Echinococcus granulosus hypothetical protein 0.001 0.0065 0.0028
Brugia malayi sulfakinin receptor protein 0.001 0.0065 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0325 0.5266
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0057 0.0617 0.058
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0076 0.0086
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0065 0.0026
Loa Loa (eye worm) hypothetical protein 0.0254 0.2936 0.2943
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0025 0.0239 0.0237
Schistosoma mansoni amine GPCR 0.001 0.0065 0.0066
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0039 0.0635
Schistosoma mansoni hypothetical protein 0.0018 0.0163 0.0314
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Schistosoma mansoni opsin-like receptor 0.001 0.0065 0.0066
Schistosoma mansoni amine GPCR 0.001 0.0065 0.0066
Entamoeba histolytica hypothetical protein 0.003 0.0296 0.1755
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0817 0.9565 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0018 0.0163 0.013
Schistosoma mansoni fkbp-rapamycin associated protein 0.0032 0.0325 0.0723
Brugia malayi dehydrogenases, short chain protein 9 0.0008 0.0039 0.0043
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0057 0.0617 0.1699
Echinococcus multilocularis neuropeptide s receptor 0.001 0.0065 0.0026
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0254 0.2936 0.2908
Echinococcus granulosus G protein coupled receptor 139 0.001 0.0065 0.0028
Onchocerca volvulus 0.0132 0.1504 0.5057
Loa Loa (eye worm) hypothetical protein 0.0122 0.1379 0.1381
Brugia malayi hypothetical protein 0.0122 0.1379 0.1616
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0296 0.48
Onchocerca volvulus 0.0254 0.2936 1
Loa Loa (eye worm) oxidoreductase 0.0008 0.0039 0.0037
Loa Loa (eye worm) hypothetical protein 0.0122 0.1379 0.1381
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0011 0.0076 0.0251
Echinococcus granulosus serotonin receptor 0.001 0.0065 0.0028
Loa Loa (eye worm) hypothetical protein 0.0254 0.2936 0.2943
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0643 1
Loa Loa (eye worm) ACC-1 protein 0.0254 0.2936 0.2943
Echinococcus granulosus orexin receptor type 2 0.001 0.0065 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0368 0.5965
Loa Loa (eye worm) hypothetical protein 0.0254 0.2936 0.2943
Echinococcus granulosus nAChR subunit 0.0254 0.2936 0.3041
Echinococcus granulosus neuropeptide s receptor 0.001 0.0065 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.1379 0.1381
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0048 0.0009
Brugia malayi neuropeptide F receptor 0.001 0.0065 0.0073
Echinococcus multilocularis 0.0011 0.0076 0.0037
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0039 0.0635
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0643 0.0634
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0514 0.0499
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0008 0.0039 0.0043
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0643 0.9768
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0065 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0325 0.5266
Schistosoma mansoni nAChR subunit 0.0254 0.2936 0.7332
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0011 0.0076 0.0251
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.0065 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0296 0.48
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0048 0.0009
Loa Loa (eye worm) hypothetical protein 0.0122 0.1379 0.1381
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0163 0.013
Loa Loa (eye worm) hypothetical protein 0.0036 0.0368 0.0367
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0065 0.0066
Schistosoma mansoni neuropeptide receptor 0.001 0.0065 0.0066
Onchocerca volvulus 0.0132 0.1504 0.5057
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0163 0.2648
Brugia malayi G-protein coupled receptor 0.001 0.0065 0.0073
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0011 0.0076 0.006
Echinococcus multilocularis g protein coupled receptor 0.001 0.0065 0.0026
Echinococcus multilocularis expressed protein 0.0009 0.0047 0.0008
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0132 0.1504 0.3707
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0296 0.48
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0254 0.2936 0.7332
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0011 0.0076 0.1366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Onchocerca volvulus 0.001 0.0065 0.009
Brugia malayi Dopamine receptor 0.001 0.0065 0.0073
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0254 0.2936 0.3444
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0011 0.0076 0.0093
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0254 0.2936 0.3041
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0011 0.0076 0.006
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.0065 0.0066
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0254 0.2936 0.2908
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0065 0.0026
Loa Loa (eye worm) hypothetical protein 0.0254 0.2936 0.2943
Loa Loa (eye worm) hypothetical protein 0.0132 0.1504 0.1506
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.1379 0.1616
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0011 0.0076 0.1366
Schistosoma mansoni poly [ADP-ribose] polymerase 0.003 0.0296 0.0651
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.0065 0.0066
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0122 0.1379 0.1407
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0076 0.0086
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0254 0.2936 0.2943
Plasmodium falciparum replication factor C subunit 1, putative 0.0031 0.0308 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0254 0.2936 0.2908
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.1427 0.1429
Leishmania major phosphatidylinositol kinase related protein, putative 0.0011 0.0076 0.0108
Loa Loa (eye worm) hypothetical protein 0.0122 0.1379 0.1381
Echinococcus granulosus nibrin 0.0031 0.0308 0.0282
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0065 0.0028
Echinococcus multilocularis g protein coupled receptor 0.001 0.0065 0.0026
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0163 0.0377
Loa Loa (eye worm) dehydrogenase 0.0008 0.0039 0.0037
Entamoeba histolytica hypothetical protein 0.003 0.0296 0.1755
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0039 0.0043
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0122 0.1379 0.1381
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0076 0.006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0254 0.2936 0.3444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Brugia malayi Smad1 0.0009 0.0048 0.0053
Loa Loa (eye worm) TYRA-2 protein 0.001 0.0065 0.0063
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0011 0.0076 0.0251
Echinococcus granulosus g protein coupled receptor 0.001 0.0065 0.0028
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0065 0.0028
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0011 0.0076 0.1231
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0308 0.4656
Brugia malayi G protein-coupled receptor F59B2.13 0.001 0.0065 0.0073
Echinococcus multilocularis geminin 0.0343 0.399 0.3967
Echinococcus multilocularis sex peptide receptor 0.001 0.0065 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Echinococcus multilocularis serine protein kinase ATM 0.0032 0.0325 0.0287
Loa Loa (eye worm) oxidoreductase 0.0008 0.0039 0.0037
Trypanosoma brucei poly(adp-ribose) polymerase 0.003 0.0296 0.4447
Loa Loa (eye worm) hypothetical protein 0.0132 0.1504 0.1506
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.0065 0.0066
Loa Loa (eye worm) hypothetical protein 0.0122 0.1379 0.1381
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0132 0.1504 0.1762
Brugia malayi hypothetical protein 0.0122 0.1379 0.1616
Loa Loa (eye worm) oxidoreductase 0.0008 0.0039 0.0037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0065 0.0066
Brugia malayi Retinol dehydrogenase 12 0.0008 0.0039 0.0043
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.003 0.0296 0.1755
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0057 0.0617 0.3946
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0039 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0163 0.2648
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0163 0.0363
Echinococcus granulosus glycine receptor subunit alpha 1 0.0254 0.2936 0.3041
Echinococcus granulosus Smad4 0.0009 0.0048 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0163 0.0377
Loa Loa (eye worm) hypothetical protein 0.0031 0.0308 0.0307
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Onchocerca volvulus 0.001 0.0065 0.009
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0254 0.2936 0.2908
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Echinococcus granulosus tankyrase 0.0208 0.2392 0.247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0011 0.0076 0.1231
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0048 0.0009
Echinococcus granulosus g protein coupled receptor 0.001 0.0065 0.0028
Schistosoma mansoni ap endonuclease 0.0018 0.0163 0.0312
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.0161
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.0065 0.0066
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0.0047 0.0301
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0011 0.0076 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Brugia malayi hypothetical protein 0.0031 0.0308 0.0359
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0011 0.0076 0.0112
Echinococcus multilocularis smad 0.0009 0.0048 0.0009
Onchocerca volvulus 0.0122 0.1379 0.4625
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.0065 0.0026
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0032 0.0325 0.0873
Brugia malayi larval opioid receptor 0.001 0.0065 0.0073
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0039 0.0635
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0643 0.1776
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0643 0.1528
Schistosoma mansoni biogenic amine receptor 0.001 0.0065 0.0066
Echinococcus granulosus glycine receptor subunit alpha 1 0.0254 0.2936 0.3041
Echinococcus granulosus liprin beta 1 0.0018 0.0163 0.013
Onchocerca volvulus Putative nachr subunit 0.0254 0.2936 1
Entamoeba histolytica hypothetical protein 0.0077 0.0855 0.5568
Loa Loa (eye worm) oxidoreductase 0.0008 0.0039 0.0037
Schistosoma mansoni amine GPCR 0.001 0.0065 0.0066
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0032 0.0325 0.03
Loa Loa (eye worm) hypothetical protein 0.0254 0.2936 0.2943
Brugia malayi Tachykinin-like peptides receptor 99D 0.001 0.0065 0.0073
Brugia malayi Dehydrogenases, short chain protein 2 0.0008 0.0039 0.0043
Schistosoma mansoni neurotransmitter gated ion channel 0.0122 0.1379 0.3391
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0011 0.0076 0.0093
Schistosoma mansoni nAChR subunit 0.0254 0.2936 0.7332
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0065 0.0028
Loa Loa (eye worm) hypothetical protein 0.0122 0.1379 0.1381
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0065 0.0026
Echinococcus multilocularis serotonin receptor 0.001 0.0065 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0368 0.5965
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0122 0.1379 0.1407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0325 0.5266
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0817 0.9565 0.9563
Brugia malayi hypothetical protein 0.001 0.0065 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.0161
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0057 0.0617 0.0607
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0325 0.0378
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0031 0.0308 0.4996
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0065 0.0028
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0163 0.2636
Schistosoma mansoni sarm1 0.0018 0.0163 0.0314
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0122 0.1379 0.1381
Treponema pallidum DNA ligase (lig) 0.0031 0.0308 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0057 0.0617 0.1699
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0011 0.0076 0.0093
Loa Loa (eye worm) hypothetical protein 0.0031 0.0308 0.0307
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0065 0.0028
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0031 0.0308 0.0359
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0048 0.0045
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.0065 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0308 0.4996
Schistosoma mansoni ferritin light chain 0.0009 0.0047 0.0021
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0163 0.0124
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.001 0.0065 0.0073
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0254 0.2936 0.3444
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.0076 0.0073
Toxoplasma gondii FATC domain-containing protein 0.0032 0.0325 0.4622
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0025 0.0239 0.0201
Loa Loa (eye worm) LGC-31 protein 0.0254 0.2936 0.2943
Echinococcus granulosus serine protein kinase ATM 0.0032 0.0325 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0065 0.0026
Echinococcus multilocularis nAChR subunit 0.0254 0.2936 0.2908
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.0076 0.0073
Schistosoma mansoni ferritin light chain 0.0009 0.0047 0.0021
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0011 0.0076 0.1231
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.0065 0.0026
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0018 0.0163 0.0314
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0163 0.2136
Schistosoma mansoni apoferritin-2 0.0009 0.0047 0.0021
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0065 0.0026
Loa Loa (eye worm) hypothetical protein 0.0132 0.1504 0.1506
Brugia malayi Neurabin protein 1 0.0018 0.0163 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0065 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0296 0.48
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0065 0.0066
Loa Loa (eye worm) acetylcholine receptor protein 0.0122 0.1379 0.1381
Schistosoma mansoni hypothetical protein 0.001 0.0065 0.0066
Entamoeba histolytica hypothetical protein 0.0077 0.0855 0.5568
Onchocerca volvulus 0.001 0.0065 0.009
Plasmodium falciparum protein kinase, putative 0.0018 0.0163 0.4615
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.001 0.0065 0.009
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0122 0.1379 0.1616
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0254 0.2936 0.2908
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.0065 0.0026
Loa Loa (eye worm) hypothetical protein 0.0606 0.7088 0.711
Giardia lamblia Hypothetical protein 0.0011 0.0076 0.0636
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.001 0.0065 0.0066
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0163 0.2136
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0065 0.0066
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0065 0.0063
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.0047 0.0134
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0163 0.4587
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.0065 0.0026
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0308 0.0822
Loa Loa (eye worm) hypothetical protein 0.0008 0.0039 0.0037
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0065 0.0066
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0018 0.0163 0.2648
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.0065 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Schistosoma mansoni nAChR subunit 0.0254 0.2936 0.7332
Brugia malayi dehydrogenases, short chain protein 2 0.0008 0.0039 0.0043
Loa Loa (eye worm) hypothetical protein 0.003 0.0296 0.0294
Loa Loa (eye worm) hypothetical protein 0.0031 0.0308 0.0307
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.0065 0.0066
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0011 0.0076 0.0636
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0065 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0057 0.0617 0.0721
Toxoplasma gondii exonuclease III APE 0.0018 0.0163 0.1996
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0514 0.0499
Echinococcus multilocularis tankyrase 0.0208 0.2392 0.2362
Schistosoma mansoni neurotransmitter gated ion channel 0.0132 0.1504 0.3707
Echinococcus multilocularis somatostatin receptor 0.001 0.0065 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0076 0.1231
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0254 0.2936 0.2943
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Brugia malayi Cation transporter family protein 0.0254 0.2936 0.3444
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.0065 0.0028
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0254 0.2936 0.7332
Brugia malayi MH2 domain containing protein 0.0009 0.0048 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Schistosoma mansoni nAChR subunit 0.0254 0.2936 0.7332
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0011 0.0076 0.0595
Schistosoma mansoni amine GPCR 0.001 0.0065 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0065 0.0026
Brugia malayi oxidoreductase 0.0008 0.0039 0.0043
Loa Loa (eye worm) tnks protein 0.0189 0.2179 0.2183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0325 0.5266
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0039 0.0043
Schistosoma mansoni histamine h1 receptor 0.001 0.0065 0.0066
Onchocerca volvulus 0.0018 0.0163 0.0429
Schistosoma mansoni ferritin 0.0009 0.0047 0.0021
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0122 0.1379 0.1345
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0254 0.2936 0.3041
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0065 0.0063
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.0065 0.0063
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0039 0.0635
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0036 0.0368 0.5692
Echinococcus multilocularis orexin receptor type 2 0.001 0.0065 0.0026
Brugia malayi WGR domain containing protein 0.003 0.0296 0.0344
Brugia malayi hypothetical protein 0.001 0.0065 0.0073
Loa Loa (eye worm) hypothetical protein 0.0008 0.0039 0.0037
Onchocerca volvulus 0.0254 0.2936 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0057 0.0617 1
Schistosoma mansoni myosin xvIII 0.001 0.0065 0.0066
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0254 0.2936 0.3444
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0065 0.0028
Brugia malayi hypothetical protein 0.001 0.0065 0.0073
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0031 0.0308 1
Entamoeba histolytica hypothetical protein 0.0077 0.0855 0.5568
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0065 0.0026
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0076 0.0086
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0065 0.0028
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0065 0.0026
Loa Loa (eye worm) phosphatidylinositol 3 0.0057 0.0617 0.0616
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0039 0.0635
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0011 0.0076 0.0251
Echinococcus granulosus Sterile alpha motif SAM 0.0018 0.0163 0.013
Onchocerca volvulus 0.001 0.0065 0.009
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0254 0.2936 0.2943
Onchocerca volvulus 0.001 0.0065 0.009
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0048 0.0045
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0011 0.0076 0.0636
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.0065 0.0026
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0065 0.0028
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0254 0.2936 0.3444
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0011 0.0076 0.0039
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0011 0.0076 0.0595
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0011 0.0076 0.0636
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0643 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.0076 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0325 0.5266
Schistosoma mansoni topbp1 0.0031 0.0308 0.0681
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0057 0.0617 0.1766
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.001 0.0065 0.0073
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.0065 0.0063
Onchocerca volvulus Tankyrase homolog 0.0186 0.2142 0.7259
Brugia malayi hypothetical protein 0.0018 0.0163 0.0189
Schistosoma mansoni tankyrase 0.0208 0.2395 0.5963
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0039 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0296 0.48
Brugia malayi G-protein coupled receptor 0.001 0.0065 0.0073
Schistosoma mansoni hypothetical protein 0.0343 0.399 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.0065 0.0028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0065 0.0066
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.1379 0.1616
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.0065 0.0026
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0643 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0011 0.0076 0.1231
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0065 0.0026
Echinococcus multilocularis poly (ADP ribose) polymerase 0.003 0.0296 0.0258
Loa Loa (eye worm) hypothetical protein 0.0008 0.0039 0.0037
Loa Loa (eye worm) oxidoreductase 0.0008 0.0039 0.0037
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0039 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.0065 0.0066
Echinococcus granulosus poly adp ribose polymerase 2 0.003 0.0296 0.027
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0011 0.0076 0.0251
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0031 0.0308 0.4996
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0011 0.0076 0.0636
Loa Loa (eye worm) phosphatidylinositol kinase 0.0011 0.0076 0.0073
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0011 0.0076 0.0039
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.0047 0.0134
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0011 0.0076 0.0093
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0039 0.0037
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0011 0.0076 0.0636
Schistosoma mansoni hypothetical protein 0.0025 0.0239 0.0506
Entamoeba histolytica zinc finger protein, putative 0.003 0.0296 0.1755
Schistosoma mansoni smad1 5 8 and 0.0009 0.0048 0.0022
Schistosoma mansoni opsin-like receptor 0.001 0.0065 0.0066
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0065 0.0026
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0018 0.0163 0.0161
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0065 0.0026
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0254 0.2936 0.7332
Loa Loa (eye worm) hypothetical protein 0.0021 0.0196 0.0194
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0163 0.2044
Brugia malayi MH2 domain containing protein 0.0009 0.0048 0.0053
Schistosoma mansoni lip-related protein (liprin) alpha 0.0018 0.0163 0.0314
Brugia malayi neuropeptide F receptor 0.001 0.0065 0.0073
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0254 0.2936 0.3041
Schistosoma mansoni nAChR subunit 0.0254 0.2936 0.7332
Schistosoma mansoni hypothetical protein 0.001 0.0065 0.0066
Schistosoma mansoni adenoreceptor 0.001 0.0065 0.0066
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0254 0.2936 0.3444
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0254 0.2936 0.3041
Chlamydia trachomatis DNA ligase 0.0031 0.0308 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0254 0.2936 0.3444
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0308 0.4996
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0855 0.2064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Echinococcus granulosus fmrfamide receptor 0.001 0.0065 0.0028
Brugia malayi hypothetical protein 0.001 0.0065 0.0073
Brugia malayi Cation transporter family protein 0.0254 0.2936 0.3444
Onchocerca volvulus 0.001 0.0065 0.009
Echinococcus multilocularis liprin beta 1 0.0018 0.0163 0.0125
Onchocerca volvulus 0.001 0.0065 0.009
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0254 0.2936 0.2908
Schistosoma mansoni smad 0.0009 0.0048 0.0022
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0008 0.0039 0.0043
Echinococcus granulosus expressed protein 0.0009 0.0047 0.0009
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0039 0.0635
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0296 0.48
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0065 0.0028
Brugia malayi putative neuropeptide receptor 0.001 0.0065 0.0073
Brugia malayi putative neuropeptide receptor NPR1 0.001 0.0065 0.0073
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0011 0.0076 0.1231
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0065 0.0026
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.0065 0.0028
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0122 0.1379 0.1345
Loa Loa (eye worm) hypothetical protein 0.0008 0.0039 0.0037
Schistosoma mansoni biogenic amine receptor 0.001 0.0065 0.0066
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0057 0.0617 1
Brugia malayi hypothetical protein 0.001 0.0065 0.0073
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0039 0.0043
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0011 0.0076 0.1231
Echinococcus multilocularis g-protein coupled receptor 0.001 0.0065 0.0026
Loa Loa (eye worm) Smad1 0.0009 0.0048 0.0045
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0031 0.0308 0.4456
Loa Loa (eye worm) follicle stimulating hormone receptor 0.001 0.0065 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0325 0.5266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0325 0.0323
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0011 0.0076 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Onchocerca volvulus 0.001 0.0065 0.009
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.1379 0.1616
Loa Loa (eye worm) dehydrogenase 0.0008 0.0039 0.0037
Echinococcus granulosus liprin alpha 2 0.0018 0.0163 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0308 0.4996
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0011 0.0076 0.1231
Schistosoma mansoni amine GPCR 0.001 0.0065 0.0066
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0011 0.0076 0.0112
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.0065 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Schistosoma mansoni chromosome transmission fidelity factor 0.0031 0.0308 0.0681
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0011 0.0076 0.0636
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0122 0.1379 0.3391
Brugia malayi Dehydrogenases, short chain protein 30 0.0008 0.0039 0.0043
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0065 0.0066
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.0526 0.6144 1
Schistosoma mansoni hypothetical protein 0.0018 0.0163 0.0314
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0132 0.1504 0.3707
Brugia malayi MH1 domain containing protein 0.0009 0.0048 0.0053
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0011 0.0076 0.1231
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0018 0.0163 0.0125
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0057 0.0617 0.1699
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.0065 0.0026
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0163 0.4419
Schistosoma mansoni smad1 5 8 and 0.0009 0.0048 0.0022
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.0065 0.0026
Brugia malayi hypothetical protein 0.0008 0.0039 0.0043
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0065 0.0026
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0008 0.0039 0.0635
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0008 0.0039 0.0635
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0039 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0296 0.48
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0065 0.0028
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0011 0.0076 0.0112
Schistosoma mansoni hypothetical protein 0.0011 0.0076 0.0093
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.0065 0.0026
Loa Loa (eye worm) hypothetical protein 0.0132 0.1504 0.1506
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0057 0.0617 0.0721
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0011 0.0076 0.0108
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.0161
Schistosoma mansoni nAChR subunit 0.0254 0.2936 0.7332
Schistosoma mansoni nAChR subunit 0.0122 0.1379 0.3391
Loa Loa (eye worm) hypothetical protein 0.0728 0.852 0.8547
Loa Loa (eye worm) oxidoreductase 0.0008 0.0039 0.0037
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0163 0.4587
Loa Loa (eye worm) hypothetical protein 0.0122 0.1379 0.1381
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0011 0.0076 0.0039
Echinococcus granulosus nAChR subunit 0.0132 0.1504 0.1538
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0032 0.0325 0.4945
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0008 0.0039 0.0635
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0011 0.0076 0.0636
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0254 0.2936 0.2943
Brugia malayi hypothetical protein 0.0077 0.0855 0.1
Loa Loa (eye worm) hypothetical protein 0.0254 0.2936 0.2943
Loa Loa (eye worm) hypothetical protein 0.0122 0.1379 0.1381
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0047 0.0134
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0011 0.0076 0.0039
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0132 0.1504 0.1762
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0308 0.0822
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0011 0.0076 0.0595
Schistosoma mansoni smad1 5 8 and 0.0009 0.0048 0.0022
Brugia malayi Liprin-alpha 2 0.0018 0.0163 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Echinococcus granulosus smad 0.0009 0.0048 0.0009
Echinococcus granulosus ferritin 0.0009 0.0047 0.0009
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0031 0.0308 0.4996
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0514 0.1202
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0039 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Giardia lamblia Replication factor C, subunit 1 0.0031 0.0308 0.4656
Loa Loa (eye worm) hypothetical protein 0.0851 0.9968 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0057 0.0617 0.1699
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0011 0.0076 0.1366
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0065 0.0026
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0163 0.0188
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0039 0.0043
Schistosoma mansoni DNA ligase IV 0.0031 0.0308 0.0681
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.003 0.0296 0.0786
Brugia malayi hypothetical protein 0.001 0.0065 0.0073
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.0065 0.0066
Loa Loa (eye worm) hypothetical protein 0.0132 0.1504 0.1506
Onchocerca volvulus 0.001 0.0065 0.009
Leishmania major phosphatidylinositol 4-kinase, putative 0.0011 0.0076 0.0108
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0254 0.2936 0.2908
Schistosoma mansoni poly [ADP-ribose] polymerase 0.003 0.0296 0.0651
Schistosoma mansoni ap endonuclease 0.0018 0.0163 0.0312
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0011 0.0076 0.1231
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0048 0.0009
Echinococcus multilocularis g protein coupled receptor 0.001 0.0065 0.0026
Loa Loa (eye worm) hypothetical protein 0.0254 0.2936 0.2943
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.001 0.0065 0.0073
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.0065 0.0028
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.0065 0.0028
Echinococcus multilocularis allatostatin A receptor 0.001 0.0065 0.0026
Schistosoma mansoni nAChR subunit 0.0122 0.1379 0.3391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0325 0.5266
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0011 0.0076 0.0039
Loa Loa (eye worm) hypothetical protein 0.0008 0.0039 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0163 0.2648
Schistosoma mansoni apoferritin-2 0.0009 0.0047 0.0021
Trypanosoma cruzi target of rapamycin kinase 3 0.0057 0.0617 0.1766
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0514 0.0477
Brugia malayi Serotonin/octopamine receptor family protein 7 0.001 0.0065 0.0073
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0031 0.0308 0.1837
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0254 0.2936 0.7332
Loa Loa (eye worm) hypothetical protein 0.0254 0.2936 0.2943
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0011 0.0076 0.0595
Brugia malayi ORL1-like opioid receptor 0.001 0.0065 0.0073
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0254 0.2936 0.2943
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.1427 0.1429
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0065 0.0066
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0011 0.0076 0.0037
Brugia malayi AKH receptor 0.001 0.0065 0.0073
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0047 0.0134
Echinococcus granulosus sex peptide receptor 0.001 0.0065 0.0028
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0065 0.0028
Brugia malayi hypothetical protein 0.0008 0.0039 0.0043
Echinococcus granulosus allatostatin A receptor 0.001 0.0065 0.0028
Plasmodium vivax hypothetical protein 0.0011 0.0076 0.006
Onchocerca volvulus 0.001 0.0065 0.009
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0254 0.2936 0.3041
Mycobacterium tuberculosis Conserved hypothetical protein 0.0011 0.0076 0.0609
Entamoeba histolytica hypothetical protein 0.003 0.0296 0.1755
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0254 0.2936 0.2908
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0011 0.0076 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0163 0.2648
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0057 0.0617 0.1766
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0039 0.0043
Schistosoma mansoni topbp1 0.0031 0.0308 0.0681
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0008 0.0039 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0196 0.3177
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0011 0.0076 0.0112
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0039 0.0043
Leishmania major hypothetical protein, unknown function 0.0011 0.0076 0.0108
Brugia malayi topoisomerase 0.0031 0.0308 0.0359
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Brugia malayi Serotonin receptor 0.001 0.0065 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Brugia malayi WGR domain containing protein 0.003 0.0296 0.0344
Echinococcus granulosus poly ADP ribose polymerase 1 0.003 0.0296 0.027
Trypanosoma cruzi hypothetical protein, conserved 0.0286 0.3311 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0011 0.0076 0.0037
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0047 0.0301
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0011 0.0076 0.1231
Brugia malayi Melatonin receptor type 1A 0.001 0.0065 0.0073
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0011 0.0076 0.006
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0011 0.0076 0.1231
Toxoplasma gondii target of rapamycin (TOR), putative 0.0057 0.0617 0.9347
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0039 0.0043
Onchocerca volvulus 0.001 0.0065 0.009
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0039 0.0635
Echinococcus multilocularis serotonin receptor 0.001 0.0065 0.0026
Schistosoma mansoni nAChR subunit 0.0254 0.2936 0.7332
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0018 0.0163 0.2009
Leishmania major phosphatidylinositol 3-kinase, putative 0.0011 0.0076 0.0108
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0514 0.06
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0514 0.1202
Brugia malayi follicle stimulating hormone receptor 0.001 0.0065 0.0073
Loa Loa (eye worm) oxidoreductase 0.0008 0.0039 0.0037
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.0065 0.0028
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.006 0.0657 1
Onchocerca volvulus 0.001 0.0065 0.009
Entamoeba histolytica hypothetical protein 0.003 0.0296 0.1755
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0643 0.0606
Onchocerca volvulus 0.001 0.0065 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Echinococcus granulosus g protein coupled receptor 0.001 0.0065 0.0028
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0039 0.0043
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0163 0.2044
Entamoeba histolytica hypothetical protein 0.0032 0.0325 0.1951
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0011 0.0076 0.0251
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0005 0.0004 0.0061
Brugia malayi hypothetical protein 0.0018 0.0163 0.0189
Schistosoma mansoni neuropeptide receptor 0.001 0.0065 0.0066
Echinococcus granulosus somatostatin receptor 0.001 0.0065 0.0028
Echinococcus multilocularis neuropeptide receptor 0.001 0.0065 0.0026
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0076 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0308 0.4996
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.0161
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0076 0.0086
Schistosoma mansoni neuropeptide receptor 0.001 0.0065 0.0066
Echinococcus multilocularis fmrfamide receptor 0.001 0.0065 0.0026
Schistosoma mansoni biogenic amine receptor 0.001 0.0065 0.0066
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0031 0.0308 1
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.003 0.0296 0.0294
Trichomonas vaginalis replication factor C large subunit, putative 0.0031 0.0308 0.4996
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0011 0.0076 0.0595
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0163 0.2636
Brugia malayi hypothetical protein 0.0122 0.1379 0.1616
Entamoeba histolytica protein kinase rad3, putative 0.0032 0.0325 0.1951
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Schistosoma mansoni hypothetical protein 0.0343 0.399 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0011 0.0076 0.0112
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0514 0.0477
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0065 0.0066
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0254 0.2936 0.2943
Brugia malayi hypothetical protein 0.001 0.0065 0.0073
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0065 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0076 0.1231
Schistosoma mansoni hypothetical protein 0.0018 0.0163 0.0314
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.0065 0.0063
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0039 0.0043
Loa Loa (eye worm) hypothetical protein 0.0132 0.1504 0.1506
Brugia malayi MH2 domain containing protein 0.0126 0.1427 0.1672
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0039 0.0043
Leishmania major hypothetical protein, conserved 0.0297 0.344 1
Loa Loa (eye worm) hypothetical protein 0.0254 0.2936 0.2943
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0254 0.2936 0.3041
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0008 0.0039 0.0037
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0039 0.0043
Brugia malayi coiled-coil like protein 1 0.0018 0.0163 0.0189
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.0065 0.0028
Loa Loa (eye worm) hypothetical protein 0.0011 0.0076 0.0073
Onchocerca volvulus Neuropeptide F receptor homolog 0.001 0.0065 0.009
Brugia malayi FAT domain containing protein 0.0025 0.0239 0.0278
Loa Loa (eye worm) hypothetical protein 0.0031 0.0308 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0011 0.0076 0.0037
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0032 0.0325 0.0723
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0065 0.0028
Loa Loa (eye worm) hypothetical protein 0.0132 0.1504 0.1506
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Echinococcus granulosus glycine receptor subunit beta 0.0254 0.2936 0.3041
Loa Loa (eye worm) hypothetical protein 0.0254 0.2936 0.2943
Loa Loa (eye worm) phosphatidylinositol 3 0.0057 0.0617 0.0616
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0011 0.0076 0.1231
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0032 0.0325 0.0287
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0254 0.2936 0.3041
Echinococcus granulosus neuropeptide receptor 0.001 0.0065 0.0028
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0032 0.0325 0.0873
Onchocerca volvulus 0.0018 0.0163 0.0429
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0065 0.0026
Trypanosoma cruzi FHA domain containing protein, putative 0.0031 0.0308 0.0822
Echinococcus multilocularis replication factor c subunit 1 0.0031 0.0308 0.027
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.003 0.0296 0.0258
Brugia malayi hypothetical protein 0.0122 0.1379 0.1616
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.0065 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0296 0.48
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.0065 0.0028
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0057 0.0617 0.3946
Loa Loa (eye worm) hypothetical protein 0.0254 0.2936 0.2943
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0076 0.0086
Onchocerca volvulus 0.0011 0.0076 0.0127
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0163 0.016
Loa Loa (eye worm) hypothetical protein 0.0122 0.1379 0.1381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0076 0.1231
Plasmodium vivax replication factor C subunit 1, putative 0.0031 0.0308 0.0441
Schistosoma mansoni acetylcholine receptor subunit beta 0.0122 0.1379 0.3391
Brugia malayi hypothetical protein 0.001 0.0065 0.0073
Loa Loa (eye worm) hypothetical protein 0.0157 0.1796 0.18
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0122 0.1379 0.1381
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0065 0.0066
Schistosoma mansoni ferritin 0.0009 0.0047 0.0021
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0011 0.0076 0.0251
Brugia malayi excitatory GABA receptor EXP-1A 0.0254 0.2936 0.3444
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0254 0.2936 0.3444
Echinococcus multilocularis glycine receptor subunit beta 0.0254 0.2936 0.2908
Schistosoma mansoni hypothetical protein 0.001 0.0065 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0065 0.0026
Echinococcus granulosus glycine receptor subunit alpha 1 0.0254 0.2936 0.3041
Loa Loa (eye worm) oxidoreductase 0.0008 0.0039 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0254 0.2936 0.3444
Onchocerca volvulus 0.0122 0.1379 0.4625
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0239 0.3876
Trichomonas vaginalis steroid dehydrogenase, putative 0.0008 0.0039 0.0635
Loa Loa (eye worm) oxidoreductase 0.0008 0.0039 0.0037
Brugia malayi hypothetical protein 0.001 0.0065 0.0073
Echinococcus granulosus g-protein coupled receptor 0.001 0.0065 0.0028
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0057 0.0617 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0018 0.0163 0.0203
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.0076 0.0073
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0039 0.0043
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0855 0.0856
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0254 0.2936 0.2908
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0057 0.0617 0.058
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0057 0.0617 0.1463
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0308 0.0822
Brugia malayi Pax transcription activation domain interacting protein 0.0031 0.0308 0.0359
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0065 0.0066
Loa Loa (eye worm) hypothetical protein 0.0008 0.0039 0.0037
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0254 0.2936 0.3444
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0065 0.0066
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0254 0.2936 0.2943
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0039 0.0043
Giardia lamblia GTOR 0.0057 0.0617 1
Loa Loa (eye worm) GABA receptor subunit 0.0132 0.1504 0.1506
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0122 0.1379 0.1616
Loa Loa (eye worm) hypothetical protein 0.0254 0.2936 0.2943
Giardia lamblia Phosphatidylinositol 4-kinase 0.0011 0.0076 0.0636
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0011 0.0076 0.0112
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0011 0.0076 0.0039
Echinococcus multilocularis nAChR subunit 0.0132 0.1504 0.1471
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0065 0.0066
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.003 0.0296 0.0786
Loa Loa (eye worm) hypothetical protein 0.0031 0.0308 0.0307
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0254 0.2936 0.2943
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0025 0.0239 0.021
Echinococcus granulosus neuropeptide receptor A26 0.001 0.0065 0.0028
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0254 0.2936 0.3444
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0011 0.0076 0.0073
Echinococcus multilocularis fmrfamide receptor 0.001 0.0065 0.0026
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0254 0.2936 0.3041
Loa Loa (eye worm) hypothetical protein 0.0031 0.0308 0.0307
Echinococcus granulosus stromal interaction molecule 1 0.0018 0.0163 0.013
Leishmania major phosphatidylinositol kinase, putative 0.0011 0.0076 0.0108
Schistosoma mansoni acetylcholine receptor-related 0.0122 0.1379 0.3391
Schistosoma mansoni Smad4 0.0009 0.0048 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0039 0.0037
Schistosoma mansoni neuropeptide receptor 0.001 0.0065 0.0066
Entamoeba histolytica hypothetical protein 0.0132 0.1504 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0617 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0036 0.0368 0.532
Brugia malayi GnHR receptor homolog 0.001 0.0065 0.0073
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0057 0.0617 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0011 0.0076 0.0093
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0057 0.0617 0.1766
Loa Loa (eye worm) hypothetical protein 0.0008 0.0039 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Entamoeba histolytica hypothetical protein 0.0011 0.0076 0.0251
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0254 0.2936 0.3444
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0057 0.0617 0.1463
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0163 0.0843
Onchocerca volvulus 0.0254 0.2936 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Brugia malayi MH1 domain containing protein 0.0009 0.0048 0.0053
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0254 0.2936 0.3444
Onchocerca volvulus 0.0254 0.2936 1
Brugia malayi RE15519p 0.001 0.0065 0.0073
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0063
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0728 0.852 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0296 0.48
Echinococcus granulosus replication factor c subunit 1 0.0031 0.0308 0.0282
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0065 0.0028
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0196 0.0479
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0122 0.1379 0.1345
Echinococcus multilocularis ferritin 0.0009 0.0047 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0325 0.5266

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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