Detailed information for compound 574909

Basic information

Technical information
  • TDR Targets ID: 574909
  • Name: (2R)-3-azaniumyl-2-hydroxy-propanoate
  • MW: 105.093 | Formula: C3H7NO3
  • H donors: 2 H acceptors: 3 LogP: -3.4 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]C(=O)[C@@H](C[NH3+])O
  • InChi: 1S/C3H7NO3/c4-1-2(5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
  • InChiKey: BMYNFMYTOJXKLE-UWTATZPHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R)-3-ammonio-2-hydroxypropanoate
  • (2R)-3-ammonio-2-hydroxy-propionate
  • (2R)-3-azaniumyl-2-hydroxypropanoate
  • (2R)-3-amino-2-hydroxypropanoic acid
  • (2R)-3-amino-2-hydroxy-propanoic acid
  • (2R)-3-amino-2-hydroxy-propionic acid
  • 632-11-1
  • ZINC02034713

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0035 0.004 0.0332
Leishmania major cathepsin L-like protease 0.0132 0.0277 0.3987
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0417 0.3436
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0045 0.0554
Loa Loa (eye worm) hypothetical protein 0.0041 0.0056 0.0468
Echinococcus multilocularis expressed conserved protein 0.0094 0.0185 0.0185
Trypanosoma cruzi cruzipain precursor, putative 0.0132 0.0277 0.3987
Brugia malayi MAP kinase sur-1 0.01 0.02 0.1662
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0008 0.0078
Plasmodium vivax thioredoxin reductase, putative 0.0084 0.0161 1
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.0684 1
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0286 0.0868
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.01 0.0289
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.0555 0.462
Echinococcus multilocularis snurportin 1 0.0312 0.0718 0.0718
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Brugia malayi Pre-SET motif family protein 0.003 0.0029 0.0238
Loa Loa (eye worm) hypothetical protein 0.0231 0.0519 0.4318
Brugia malayi Pre-SET motif family protein 0.0208 0.0464 0.3864
Mycobacterium ulcerans TetR family transcriptional regulator 0.1346 0.3242 1
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.1202 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0027 0.0295
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0192 0.0423 0.1288
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.005 0.0414
Toxoplasma gondii hypothetical protein 0.0048 0.0073 0.3441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.005 0.0414
Entamoeba histolytica hypothetical protein 0.0144 0.0308 0.4339
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0773 0.6414
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0417 0.3436
Echinococcus multilocularis mitogen activated protein kinase 14 0.0123 0.0256 0.0256
Onchocerca volvulus 0.0035 0.004 0.0515
Loa Loa (eye worm) hypothetical protein 0.0069 0.0124 0.1034
Echinococcus granulosus snurportin 1 0.0312 0.0718 0.2178
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0199 0.2779
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0189 0.0189
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0103 0.0855
Schistosoma mansoni hypothetical protein 0.0032 0.0034 0.0102
Onchocerca volvulus 0.0023 0.0012 0.0155
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0359 0.0359
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0027 0.0221
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.004 0.0332
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0055 0.0055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.07 0.5803
Schistosoma mansoni ap endonuclease 0.0039 0.0052 0.0157
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0013 0.0099
Echinococcus granulosus mitogen activated protein kinase 14 0.0123 0.0256 0.0777
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0047 0.0141
Onchocerca volvulus 0.0237 0.0535 0.6914
Schistosoma mansoni hypothetical protein 0.1368 0.3297 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.004 0.0278
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0052 0.0666
Schistosoma mansoni hypothetical protein 0.0055 0.009 0.0272
Schistosoma mansoni zinc finger protein 0.002 0.0004 0.0012
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.01 0.02 0.2851
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.005 0.0414
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.03 0.4336
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.005 0.0414
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0369 0.0856 0.0856
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0044 0.0135
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0029 0.0087
Trypanosoma brucei trypanothione reductase 0.0084 0.0161 0.2273
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0071 0.0129 0.038
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0189 0.0417 0.6063
Echinococcus multilocularis mitogen activated protein kinase 14 0.0123 0.0256 0.0256
Onchocerca volvulus 0.0035 0.004 0.0515
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0186 0.1499
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0044
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0129 0.038
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0199 0.0199
Schistosoma mansoni hypothetical protein 0.0032 0.0034 0.0102
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0012 0.01
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.0319 0.0967
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0052 0.0139
Onchocerca volvulus 0.0035 0.004 0.0515
Loa Loa (eye worm) hypothetical protein 0.0053 0.0086 0.0711
Plasmodium falciparum glutathione reductase 0.0029 0.0027 0.1299
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0027 0.0081
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0369 0.0856 0.7122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0007 0.0055
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0129 0.1813
Echinococcus granulosus mitogen activated protein kinase 0.01 0.02 0.0606
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1346 0.3242 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0101 0.0202 0.1684
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0129 0.038
Trichomonas vaginalis CMGC family protein kinase 0.01 0.02 0.1616
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.004 0.0278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Onchocerca volvulus 0.0035 0.004 0.0515
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0005 0.0016
Brugia malayi nuclear receptor RXR 0.002 0.0005 0.0044
Echinococcus granulosus cathepsin l1 0.0035 0.004 0.0121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0013 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.004 0.0278
Schistosoma mansoni survival motor neuron protein 0.0047 0.0071 0.0214
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0013 0.0041
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0058 0.0759
Schistosoma mansoni hypothetical protein 0.0021 0.0007 0.002
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0052 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0129 0.1771
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0071 0.0129 0.038
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0414
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.005 0.0643
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0034 0.0102
Onchocerca volvulus 0.0035 0.004 0.0515
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0042 0.0042
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0027 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.01 0.02 0.0606
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.07 0.5803
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.004 0.0278
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0078 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.005 0.0414
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0773 0.6414
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0192 0.0423 0.1288
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0417 0.3436
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.0457 0.6653
Loa Loa (eye worm) STAT protein 0.016 0.0346 0.288
Brugia malayi Cathepsin L-like precursor 0.0035 0.004 0.0332
Brugia malayi PHD-finger family protein 0.0029 0.0027 0.0223
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0027 0.0295
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0052 0.0377
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.0684 1
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0027 0.0167
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0414
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0414
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0008 0.0022
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.005 0.0414
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0045 0.0322
Brugia malayi MH2 domain containing protein 0.0246 0.0555 0.462
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0027 0.1314
Echinococcus granulosus geminin 0.1368 0.3297 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0027 0.0295
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.005 0.0414
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.07 0.5803
Echinococcus multilocularis thioredoxin glutathione reductase 0.0084 0.0162 0.0162
Mycobacterium ulcerans hypothetical protein 0.0071 0.0129 0.038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0012 0.0045
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.01 0.1379
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.005 0.005
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.01 0.02 0.2851
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.1202 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0058 0.0759
Schistosoma mansoni hypothetical protein 0.0128 0.0268 0.0814
Echinococcus granulosus mitogen activated protein kinase 3 0.01 0.02 0.0606
Mycobacterium ulcerans hypothetical protein 0.0024 0.0013 0.0021
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0013 0.0099
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.005 0.005
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0007 0.0007
Onchocerca volvulus Cathepsin L homolog 0.0035 0.004 0.0515
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.005 0.005
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.1202 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.07 0.5803
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0084 0.0161 0.0476
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.1202 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0189 0.0417 0.1266
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0045 0.0567
Loa Loa (eye worm) hypothetical protein 0.0071 0.0129 0.1077
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0007 0.0055
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0103 0.0313
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0027 0.0295
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0086 0.0244
Brugia malayi steroid hormone receptor 0.0039 0.005 0.0414
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0071 0.0214
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.0359 0.1088
Onchocerca volvulus Serine\/threonine kinase homolog 0.0189 0.0417 0.5397
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.004 0.0278
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.1202 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Plasmodium falciparum cysteine proteinase falcipain 3 0.0035 0.004 0.2159
Giardia lamblia Kinase, CMGC MAPK 0.01 0.02 0.2769
Echinococcus multilocularis cysteine protease 0.0035 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0044
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0013 0.0021
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0035 0.004 0.0332
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.005 0.0414
Echinococcus granulosus cathepsin L cysteine proteinase 0.0035 0.004 0.0121
Brugia malayi RNA binding protein 0.0135 0.0286 0.2382
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0027 0.0295
Schistosoma mansoni hypothetical protein 0.0029 0.0027 0.0081
Onchocerca volvulus 0.0071 0.0129 0.1674
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0129 0.1077
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0027 0.0081
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0369 0.0856 0.2597
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0007 0.002
Loa Loa (eye worm) glutaminase 0.0277 0.0632 0.526
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0032 0.0034 0.028
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0047 0.0141
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0008 0.0022
Plasmodium falciparum thioredoxin reductase 0.0029 0.0027 0.1299
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0052 0.0377
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.07 0.5803
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.0817 0.6783
Echinococcus multilocularis peregrin 0.0032 0.0033 0.0033
Brugia malayi Bromodomain containing protein 0.0076 0.0141 0.1172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.005 0.0414
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.0286 0.2382
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.01 0.02 1
Leishmania major hypothetical protein, conserved 0.0206 0.0457 0.6653
Echinococcus granulosus FTZ F1 alpha 0.0039 0.005 0.0151
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0045 0.199
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0007 0.002
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.01 0.02 0.2851
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0027 0.0027
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.03 0.4336
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0078 0.0222
Loa Loa (eye worm) hypothetical protein 0.0122 0.0254 0.2111
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.004 0.004
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0045 0.0322
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.005 0.0151
Schistosoma mansoni hypothetical protein 0.1368 0.3297 1
Trichomonas vaginalis CMGC family protein kinase 0.01 0.02 0.1616
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1346 0.3242 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0034 0.0034
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.0319 0.0967
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0007 0.0055
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0027 0.1035
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0223
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.005 0.0151
Schistosoma mansoni hypothetical protein 0.0041 0.0056 0.0171
Loa Loa (eye worm) hypothetical protein 0.005 0.0078 0.0647
Giardia lamblia Kinase, PLK 0.0189 0.0417 0.5913
Echinococcus granulosus muscleblind protein 0.0298 0.0683 0.2071
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.005 0.0414
Mycobacterium ulcerans hypothetical protein 0.0024 0.0013 0.0021
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.005 0.005
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0773 0.6414
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0013 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0369 0.0856 0.2597
Leishmania major cathepsin L-like protease 0.0132 0.0277 0.3987
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0029 0.0087
Echinococcus granulosus cathepsin l1 0.0023 0.0012 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0369 0.0856 0.2597
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0129 0.038
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0417 0.3436
Mycobacterium ulcerans glutaminase 0.0277 0.0632 0.1933
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0052 0.065
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0417 0.3436
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.01 0.0304
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0058 0.0759
Loa Loa (eye worm) hypothetical protein 0.0298 0.0683 0.5681
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.004 0.004
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.005 0.0414
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0034 0.028
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.01 0.0833
Schistosoma mansoni nuclear hormone receptor 0.0039 0.005 0.0151
Entamoeba histolytica cysteine protease, putative 0.0035 0.004 0.0479
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0507
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0027 0.1035
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0058 0.0759
Brugia malayi RNA, U transporter 1 0.0083 0.0159 0.132
Mycobacterium ulcerans transcriptional regulator 0.1346 0.3242 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.005 0.0414
Brugia malayi hypothetical protein 0.0231 0.0519 0.4318
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0008 0.0022
Loa Loa (eye worm) fibroinase 0.0035 0.004 0.0332
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0045 0.0567
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0414
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0013 0.0057
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.01 0.02 0.2851
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.005 0.0414
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0027 0.0062
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.005 0.0151
Loa Loa (eye worm) cysteine protease 0.0035 0.004 0.0332
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.1202 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.0304 0.0304
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0027 0.0295
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.01
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0005 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.004 0.0278
Echinococcus multilocularis muscleblind protein 0.0298 0.0683 0.0683
Loa Loa (eye worm) hypothetical protein 0.0298 0.0683 0.5681
Schistosoma mansoni alpha-glucosidase 0.0142 0.0303 0.0918
Echinococcus granulosus GPCR family 2 0.0032 0.0034 0.0102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.004 0.0278
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.005 0.0151
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0013 0.0021
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0052 0.0157
Schistosoma mansoni hypothetical protein 0.0041 0.0056 0.0171
Trypanosoma cruzi cysteine peptidase, putative 0.0132 0.0277 0.3987
Leishmania major cathepsin L-like protease 0.0035 0.004 0.0491
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.005 0.0643
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.004 0.0278
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0286 0.0868
Leishmania major cathepsin L-like protease 0.0035 0.004 0.0491
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0086 0.5122
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.01 0.0304
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.0555 0.462
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0369 0.0856 0.2597
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0213 0.0475 0.1449
Loa Loa (eye worm) hypothetical protein 0.0071 0.0129 0.1077
Echinococcus multilocularis microtubule associated protein 2 0.134 0.3228 0.3228
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0071 0.0071
Trichomonas vaginalis set domain proteins, putative 0.0237 0.0535 0.4418
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.006 0.0183
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.01 0.0289
Trypanosoma cruzi trypanothione reductase, putative 0.0084 0.0161 0.2273
Schistosoma mansoni thyroid hormone receptor 0.0167 0.0363 0.11
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.005 0.0151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0464 0.3864
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.0286 0.2382
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.01
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0044
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.0718 0.5973
Mycobacterium tuberculosis Probable oxidoreductase 0.0213 0.0475 0.1449
Brugia malayi hypothetical protein 0.002 0.0005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0053 0.0086 0.0711
Onchocerca volvulus Huntingtin homolog 0.0122 0.0254 0.3281
Brugia malayi ecdysteroid receptor 0.0039 0.005 0.0414
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.0359 0.2985
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.02 0.2851
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0027 0.0167
Schistosoma mansoni kinase 0.0097 0.0192 0.0582
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0123 0.0256 0.3685
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.01 0.0289
Loa Loa (eye worm) RNA binding protein 0.0135 0.0286 0.2382
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0123 0.0256 0.2132
Brugia malayi Cathepsin L-like precursor 0.0035 0.004 0.0332
Brugia malayi hypothetical protein 0.002 0.0005 0.0044
Onchocerca volvulus 0.0021 0.0007 0.0086
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0213 0.0475 0.1449
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0027 0.0223
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0129 0.1771
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0029 0.1136
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0417 0.3436
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.004 0.0278
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0027 0.1047
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.01 0.1382
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0007 0.0055
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0339 0.1028
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0008 0.0068
Loa Loa (eye worm) hypothetical protein 0.0053 0.0086 0.0711
Brugia malayi serine/threonine-protein kinase plk-2 0.0189 0.0417 0.3472
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0045 0.0322
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0189 0.0573
Onchocerca volvulus 0.0035 0.004 0.0515
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0045 0.0322
Brugia malayi nuclear hormone receptor 0.0039 0.005 0.0414
Brugia malayi Importin beta-1 subunit 0.0029 0.0027 0.0225
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0005 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.004 0.0278
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.005 0.0151
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0123 0.0256 0.3685
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0369 0.0856 0.7122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Trypanosoma brucei glucosidase, putative 0.0037 0.0045 0.0567
Schistosoma mansoni hypothetical protein 0.0041 0.0056 0.0171
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0005 0.0016
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0192 0.0423 0.1288
Onchocerca volvulus 0.0096 0.0189 0.2441
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0027 0.1299
Brugia malayi cathepsin L-like precursor 0.0023 0.0012 0.01
Leishmania major trypanothione reductase 0.0084 0.0161 0.2273
Trichomonas vaginalis CMGC family protein kinase 0.01 0.02 0.1616
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0588
Loa Loa (eye worm) thioredoxin reductase 0.0084 0.0161 0.1336
Schistosoma mansoni glutaminase 0.0277 0.0632 0.1918
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.0304 0.0922
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0045 0.0554
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0013 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.005 0.0414
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.005 0.0414
Brugia malayi Cathepsin L-like precursor 0.0023 0.0012 0.01
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0013 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Trypanosoma cruzi cysteine peptidase, putative 0.0132 0.0277 0.3987
Trypanosoma brucei polo-like protein kinase 0.0189 0.0417 0.6063
Onchocerca volvulus Cathepsin L homolog 0.0035 0.004 0.0515
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0052 0.293
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.012 0.0249 0.3575
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.005 0.0151
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0052 0.0666
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0052 0.063
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0045 0.0375
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0511 0.1202 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0035 0.004 0.2159
Loa Loa (eye worm) hypothetical protein 0.0052 0.0084 0.0697
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0013 0.0021
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0027 0.0027
Echinococcus multilocularis mitogen activated protein kinase 11 0.0123 0.0256 0.0256
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.0268 0.0814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0027 0.0062
Echinococcus multilocularis mitogen activated protein kinase 3 0.01 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0414
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0027 0.1299
Echinococcus granulosus zinc finger protein 0.002 0.0004 0.0012
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.0319 0.0967
Toxoplasma gondii cathepsin CPL 0.0035 0.004 0.1721
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0359 0.0359
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.005 0.0151
Echinococcus granulosus mitogen activated protein kinase 11 0.0123 0.0256 0.0777
Plasmodium vivax importin-beta 2, putative 0.0029 0.0027 0.1322
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0199 0.0605
Echinococcus granulosus tar DNA binding protein 0.0135 0.0286 0.0868
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.07 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0202 0.1684
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0027 0.0295
Plasmodium falciparum thioredoxin reductase 0.0084 0.0161 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0008 0.0065
Echinococcus multilocularis cysteine protease 0.0035 0.004 0.004
Brugia malayi PHD-finger family protein 0.0025 0.0017 0.0143
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0144 0.0308 0.0933
Echinococcus granulosus expressed conserved protein 0.0094 0.0185 0.056
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0141 0.0428
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0144 0.0308 0.0308
Brugia malayi Cathepsin L-like precursor 0.0035 0.004 0.0332
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0189 0.0417 0.0417
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0129 0.1077
Trypanosoma cruzi polo-like protein kinase, putative 0.0189 0.0417 0.6063
Loa Loa (eye worm) hypothetical protein 0.0053 0.0086 0.0711
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0225
Loa Loa (eye worm) hypothetical protein 0.0122 0.0254 0.2111
Giardia lamblia PHD finger protein 15 0.0029 0.0027 0.0271
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0501
Leishmania major cysteine peptidase A (CPA) 0.0035 0.004 0.0491
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0027 0.1299
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0332
Entamoeba histolytica hypothetical protein 0.0144 0.0308 0.4339
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.01 0.0289
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0129 0.038
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0013 0.0021
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0052 0.0373
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.0457 0.6653
Onchocerca volvulus 0.0028 0.0025 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0071 0.0214
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0044
Schistosoma mansoni hypothetical protein 0.0312 0.0718 0.2178
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0086 0.0244
Echinococcus multilocularis mitogen activated protein kinase 0.01 0.02 0.02
Brugia malayi CHE-14 protein 0.0043 0.006 0.0501
Trypanosoma brucei hypothetical protein, conserved 0.0206 0.0457 0.6653
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0027 0.1299
Schistosoma mansoni coup transcription factor 0.0039 0.005 0.0151
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.004 0.0278
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.005 0.0414
Mycobacterium tuberculosis Probable reductase 0.0192 0.0423 0.1288
Brugia malayi Cathepsin L-like precursor 0.0035 0.004 0.0332
Brugia malayi jmjC domain containing protein 0.0037 0.0047 0.0387
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0045 0.0375
Leishmania major cathepsin L-like protease 0.0035 0.004 0.0491
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.004 0.0121
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0203 0.0616
Echinococcus multilocularis geminin 0.1368 0.3297 0.3297
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0773 0.6414
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0027 0.0295
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0129 0.038
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.0684 1
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0773 0.6414
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.0129 0.038
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.07 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0129 0.1077
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.01 0.0304
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.01 0.02 0.1662
Echinococcus multilocularis muscleblind protein 1 0.0298 0.0683 0.0683
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0078 0.0222
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.005 0.0151
Schistosoma mansoni microtubule-associated protein tau 0.134 0.3228 0.979
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0005 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0286 0.0868
Leishmania major cathepsin L-like protease 0.0035 0.004 0.0491
Loa Loa (eye worm) ctsf protein 0.0035 0.004 0.0332
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0027 0.0295
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0045 0.0322
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0047 0.0141
Brugia malayi nuclear receptor NHR-88 0.0039 0.005 0.0414
Echinococcus multilocularis protein dispatched 1 0.0049 0.0075 0.0075
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0047 0.0387
Onchocerca volvulus 0.0039 0.005 0.0643
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0045 0.0322
Trichomonas vaginalis ran, putative 0.0022 0.0008 0.0013
Mycobacterium tuberculosis Probable dehydrogenase 0.0192 0.0423 0.1288
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0202 0.1684
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0123 0.0256 0.3685
Trypanosoma cruzi major cysteine proteinase, putative 0.0103 0.0208 0.2972
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.01
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0012 0.0077
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0027 0.0062
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0035 0.004 0.2159
Schistosoma mansoni bromodomain containing protein 0.0064 0.0112 0.034
Brugia malayi glutaminase DH11.1 0.0277 0.0632 0.526
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0027 0.0062
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0027 0.0301
Leishmania major GTP-binding protein, putative 0.0022 0.0008 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Schistosoma mansoni hypothetical protein 0.0069 0.0124 0.0377
Echinococcus granulosus cathepsin l cysteine peptidase 0.0035 0.004 0.0121
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0082 0.068
Echinococcus multilocularis protein patched 0.0043 0.006 0.006
Brugia malayi Cathepsin L-like precursor 0.0023 0.0012 0.01
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1346 0.3242 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.005 0.0151
Loa Loa (eye worm) hypothetical protein 0.01 0.0199 0.1659
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0192 0.0423 0.1288
Plasmodium vivax vivapain-2 0.0035 0.004 0.2159
Trypanosoma cruzi cysteine peptidase, putative 0.0035 0.004 0.0491
Entamoeba histolytica hypothetical protein 0.0144 0.0308 0.4339
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0027 0.0027
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.01 0.0289
Onchocerca volvulus Cathepsin F homolog 0.0035 0.004 0.0515
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0007 0.0055
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0189 0.0417 0.3472
Schistosoma mansoni ran 0.0022 0.0008 0.0025
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0027 0.0081
Entamoeba histolytica serine/threonine protein kinase, putative 0.0189 0.0417 0.5922
Brugia malayi Muscleblind-like protein 0.0298 0.0683 0.5681
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0011 0.0034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.07 0.5803
Brugia malayi P38 map kinase family protein 2 0.0123 0.0256 0.2132
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0414
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.0684 1
Loa Loa (eye worm) oxidoreductase 0.0021 0.0007 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Brugia malayi Bromodomain containing protein 0.0032 0.0033 0.0272
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0011 0.0034
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0011 0.0011
Brugia malayi Cathepsin L-like precursor 0.0035 0.004 0.0332
Entamoeba histolytica Ran family GTPase 0.0022 0.0008 0.0022
Schistosoma mansoni transcription factor LCR-F1 0.0144 0.0308 0.0933
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.004 0.0479
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.005 0.005
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.004 0.004
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0286 0.0868
Plasmodium vivax glutathione reductase, putative 0.0084 0.0161 1
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.0519 0.0519
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0007 0.0055
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0027 0.0267
Schistosoma mansoni hypothetical protein 0.0032 0.0034 0.0102
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.005 0.0151
Brugia malayi hypothetical protein 0.0144 0.0308 0.2559
Loa Loa (eye worm) glutaminase 2 0.0277 0.0632 0.526
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.005 0.0414
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0369 0.0856 0.2597
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0129 0.038
Echinococcus granulosus thioredoxin glutathione reductase 0.0084 0.0162 0.0491
Onchocerca volvulus 0.0021 0.0007 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.005 0.0414
Leishmania major importin beta-1 subunit, putative 0.0024 0.0013 0.0101
Brugia malayi Bromodomain containing protein 0.0039 0.005 0.0418
Giardia lamblia Fructose-bisphosphate aldolase 0.0305 0.07 1
Echinococcus multilocularis tar DNA binding protein 0.0135 0.0286 0.0286
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0129 0.1813
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.004 0.0479
Schistosoma mansoni alpha-glucosidase 0.0142 0.0303 0.0918
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.07 0.5803
Loa Loa (eye worm) hypothetical protein 0.0053 0.0086 0.0711
Toxoplasma gondii exonuclease III APE 0.0039 0.0052 0.2336
Schistosoma mansoni ap endonuclease 0.0039 0.0052 0.0157
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.03 0.4336
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0027 0.0295
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0055
Entamoeba histolytica acyl-coA synthetase, putative 0.0071 0.0129 0.1771
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0071 0.0129 0.038
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0027 0.1047
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0013 0.0099
Trichomonas vaginalis glutaminase, putative 0.0277 0.0632 0.5233
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0055 0.0166
Trypanosoma brucei protein kinase, putative 0.01 0.02 0.2851
Leishmania major cathepsin L-like protease 0.0035 0.004 0.0491
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.005 0.0414
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0052 0.0666
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.01 0.01
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.02 0.2851
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0008 0.0068
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.006 0.006
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0034 0.0102
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0071 0.0587
Schistosoma mansoni patched 1 0.0043 0.006 0.0183
Entamoeba histolytica hypothetical protein 0.0144 0.0308 0.4339
Echinococcus granulosus microtubule associated protein 2 0.134 0.3228 0.979
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0008 0.0065
Echinococcus granulosus importin subunit beta 1 0.0029 0.0027 0.0082
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0052 0.0052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.005 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0005 0.0044
Brugia malayi TAR-binding protein 0.0135 0.0286 0.2382
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0129 0.038
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0027 0.0301
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.005 0.0414
Plasmodium vivax vivapain-2 0.0035 0.004 0.2159
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0027 0.0295
Schistosoma mansoni hypothetical protein 0.0144 0.0308 0.0933
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.01 0.02 0.2851
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0045 0.0045
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0202 0.1684
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0027 0.0295
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0417 0.3436
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0034 0.0034
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.004 0.0332
Plasmodium falciparum importin beta, putative 0.0029 0.0027 0.1322
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0511 0.1202 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0013 0.0101
Brugia malayi glutathione reductase 0.0084 0.0161 0.1336
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.004 0.0121
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.01 0.0289
Plasmodium falciparum phd finger protein, putative 0.0029 0.0027 0.1314
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0007 0.0055
Onchocerca volvulus Glucosylceramidase homolog 0.0335 0.0773 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.006 0.0501
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.005 0.0643
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.01 0.0289
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0027 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.006 0.0448
Loa Loa (eye worm) glutathione reductase 0.0084 0.0161 0.1336
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.0268 0.0268
Loa Loa (eye worm) TAR-binding protein 0.0135 0.0286 0.2382
Echinococcus multilocularis GPCR, family 2 0.0032 0.0034 0.0034
Onchocerca volvulus 0.0047 0.0071 0.0912
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0129 0.1813
Echinococcus multilocularis thyroid hormone receptor alpha 0.0167 0.0363 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.005 0.0414
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0034 0.028
Onchocerca volvulus 0.003 0.0029 0.0369
Schistosoma mansoni hypothetical protein 0.0047 0.0071 0.0214
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0123 0.0256 0.3685
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0007 0.0055
Leishmania major cathepsin L-like protease 0.0132 0.0277 0.3987
Schistosoma mansoni alpha glucosidase 0.0037 0.0045 0.0137
Schistosoma mansoni ran 0.0022 0.0008 0.0025
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.005 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.0817 0.6783
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0027 0.1054
Plasmodium vivax SET domain protein, putative 0.003 0.0029 0.1425
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.01 0.4848
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0186 0.1499
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.005 0.005
Trichomonas vaginalis CMGC family protein kinase 0.01 0.02 0.1616
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0078 0.0222
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.0417 0.1266
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0027 0.0295
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0052 0.0139
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0007 0.0055
Schistosoma mansoni hypothetical protein 0.0041 0.0056 0.0171
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0027 0.0295
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0012 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.005 0.0414
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0086 0.5122
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.005 0.0414
Echinococcus multilocularis zinc finger protein 0.002 0.0004 0.0004
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0027 0.0295
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0414
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0369 0.0856 0.0856
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0008 0.0025
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0026 0.0078
Trypanosoma cruzi cysteine peptidase, putative 0.0132 0.0277 0.3987
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0286 0.0868
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0124 0.1034
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0052 0.0666
Schistosoma mansoni importin beta-1 0.0029 0.0027 0.0082
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.005 0.0151
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0071 0.0214
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0005 0.0044
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.005 0.0151
Brugia malayi STAT protein, DNA binding domain containing protein 0.016 0.0346 0.288
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0008 0.0098
Entamoeba histolytica hypothetical protein 0.0024 0.0013 0.0099
Onchocerca volvulus Huntingtin homolog 0.0122 0.0254 0.3281
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0192 0.0423 0.1288
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0199 0.1659
Schistosoma mansoni thyroid hormone receptor 0.0167 0.0363 0.11
Trypanosoma cruzi polo-like protein kinase, putative 0.0189 0.0417 0.6063
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0773 0.6414
Echinococcus granulosus peregrin 0.0032 0.0033 0.0099
Mycobacterium ulcerans hypothetical protein 0.0157 0.0339 0.1028
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.0359 0.2985
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0414
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0773 0.6414
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.07 0.5803
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0045 0.0567
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0129 0.1077
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0027 0.0295
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0008 0.0098
Mycobacterium tuberculosis Conserved protein 0.0024 0.0013 0.0021
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.0519 0.1574
Treponema pallidum fructose-bisphosphate aldolase 0.0305 0.07 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.0086 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0045 0.0322
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0034 0.028
Toxoplasma gondii thioredoxin reductase 0.0084 0.0161 0.7972
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0103 0.0103
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.01 0.01
Brugia malayi jmjC domain containing protein 0.0096 0.0189 0.1573
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0045 0.0137
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0213 0.0475 0.1449
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.01 0.0304
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0052 0.043
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0052 0.043
Onchocerca volvulus 0.0021 0.0007 0.0086
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.01 0.0304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0012 0.0045
Schistosoma mansoni hypothetical protein 0.0032 0.0034 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.005 0.0414
Onchocerca volvulus 0.0035 0.004 0.0515
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0419
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0045 0.0322
Onchocerca volvulus Alhambra homolog 0.0029 0.0027 0.0347
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.005 0.0151
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0052 0.293
Brugia malayi Thioredoxin reductase 0.0084 0.0161 0.1336
Echinococcus granulosus Protein patched homolog 1 0.0043 0.006 0.0183
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0045 0.0322
Echinococcus multilocularis mitogen activated protein kinase 11 0.0123 0.0256 0.0256
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.005 0.0151
Brugia malayi hypothetical protein 0.0122 0.0254 0.2111
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.008 0.1089
Plasmodium falciparum glutathione reductase 0.0084 0.0161 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.005 0.0151
Loa Loa (eye worm) hypothetical protein 0.0072 0.013 0.1085

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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