Detailed information for compound 574912

Basic information

Technical information
  • TDR Targets ID: 574912
  • Name: (2S)-3-azaniumyl-2-hydroxy-propanoate
  • MW: 105.093 | Formula: C3H7NO3
  • H donors: 2 H acceptors: 3 LogP: -3.4 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]C(=O)[C@H](C[NH3+])O
  • InChi: 1S/C3H7NO3/c4-1-2(5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
  • InChiKey: BMYNFMYTOJXKLE-REOHCLBHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-3-ammonio-2-hydroxypropanoate
  • (2S)-3-ammonio-2-hydroxy-propionate
  • (2S)-3-azaniumyl-2-hydroxypropanoate
  • (2S)-3-amino-2-hydroxypropanoic acid
  • (2S)-3-amino-2-hydroxy-propanoic acid
  • (2S)-3-amino-2-hydroxy-propionic acid
  • (S)-2-Hydroxy-beta-alanine
  • (S)-3-Amino-2-hydroxypropionic acid
  • 06054_FLUKA
  • L-Isoserine
  • 632-13-3
  • ZINC02034711

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0045 0.0322
Echinococcus multilocularis mitogen activated protein kinase 11 0.0123 0.0256 0.0256
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Plasmodium falciparum glutathione reductase 0.0084 0.0161 1
Brugia malayi hypothetical protein 0.0122 0.0254 0.2111
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.008 0.1089
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.005 0.0151
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0045 0.0322
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0419
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.005 0.0151
Onchocerca volvulus Alhambra homolog 0.0029 0.0027 0.0347
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0052 0.293
Brugia malayi Thioredoxin reductase 0.0084 0.0161 0.1336
Echinococcus granulosus Protein patched homolog 1 0.0043 0.006 0.0183
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.005 0.0151
Loa Loa (eye worm) hypothetical protein 0.0072 0.013 0.1085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0012 0.0045
Schistosoma mansoni hypothetical protein 0.0032 0.0034 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.005 0.0414
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.01 0.0304
Onchocerca volvulus 0.0035 0.004 0.0515
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0034 0.028
Toxoplasma gondii thioredoxin reductase 0.0084 0.0161 0.7972
Treponema pallidum fructose-bisphosphate aldolase 0.0305 0.07 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.0086 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0045 0.0322
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0052 0.043
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0052 0.043
Onchocerca volvulus 0.0021 0.0007 0.0086
Brugia malayi jmjC domain containing protein 0.0096 0.0189 0.1573
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0103 0.0103
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.01 0.01
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0045 0.0137
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0213 0.0475 0.1449
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.01 0.0304
Mycobacterium ulcerans hypothetical protein 0.0157 0.0339 0.1028
Schistosoma mansoni thyroid hormone receptor 0.0167 0.0363 0.11
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0199 0.1659
Trypanosoma cruzi polo-like protein kinase, putative 0.0189 0.0417 0.6063
Echinococcus granulosus peregrin 0.0032 0.0033 0.0099
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0773 0.6414
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0008 0.0098
Mycobacterium tuberculosis Conserved protein 0.0024 0.0013 0.0021
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.0519 0.1574
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.0359 0.2985
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0414
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.07 0.5803
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0773 0.6414
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0129 0.1077
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0045 0.0567
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0027 0.0295
Trypanosoma cruzi cysteine peptidase, putative 0.0132 0.0277 0.3987
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0026 0.0078
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0052 0.0666
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0124 0.1034
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0286 0.0868
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Schistosoma mansoni importin beta-1 0.0029 0.0027 0.0082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0369 0.0856 0.0856
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0008 0.0025
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0192 0.0423 0.1288
Onchocerca volvulus Huntingtin homolog 0.0122 0.0254 0.3281
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.005 0.0151
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0005 0.0044
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0071 0.0214
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.005 0.0151
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0008 0.0098
Entamoeba histolytica hypothetical protein 0.0024 0.0013 0.0099
Brugia malayi STAT protein, DNA binding domain containing protein 0.016 0.0346 0.288
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0027 0.0295
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0052 0.0139
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0007 0.0055
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.0417 0.1266
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0027 0.0295
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0414
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0012 0.0036
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0027 0.0295
Schistosoma mansoni hypothetical protein 0.0041 0.0056 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.005 0.0414
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.005 0.0414
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0086 0.5122
Echinococcus multilocularis zinc finger protein 0.002 0.0004 0.0004
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.01 0.4848
Plasmodium vivax SET domain protein, putative 0.003 0.0029 0.1425
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0027 0.1054
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.005 0.005
Trichomonas vaginalis CMGC family protein kinase 0.01 0.02 0.1616
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0078 0.0222
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0186 0.1499
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0123 0.0256 0.3685
Onchocerca volvulus 0.0047 0.0071 0.0912
Echinococcus multilocularis GPCR, family 2 0.0032 0.0034 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0129 0.1813
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.005 0.0414
Echinococcus multilocularis thyroid hormone receptor alpha 0.0167 0.0363 0.0363
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0034 0.028
Onchocerca volvulus 0.003 0.0029 0.0369
Schistosoma mansoni hypothetical protein 0.0047 0.0071 0.0214
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.005 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.0817 0.6783
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Leishmania major cathepsin L-like protease 0.0132 0.0277 0.3987
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0007 0.0055
Schistosoma mansoni alpha glucosidase 0.0037 0.0045 0.0137
Schistosoma mansoni ran 0.0022 0.0008 0.0025
Onchocerca volvulus Glucosylceramidase homolog 0.0335 0.0773 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.006 0.0501
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.01 0.0289
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.004 0.0121
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0007 0.0055
Plasmodium falciparum phd finger protein, putative 0.0029 0.0027 0.1314
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.006 0.0448
Loa Loa (eye worm) glutathione reductase 0.0084 0.0161 0.1336
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.0268 0.0268
Loa Loa (eye worm) TAR-binding protein 0.0135 0.0286 0.2382
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.005 0.0643
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.01 0.0289
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0027 0.0295
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0202 0.1684
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0027 0.0295
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0417 0.3436
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0034 0.0034
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.004 0.0332
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0027 0.0295
Schistosoma mansoni hypothetical protein 0.0144 0.0308 0.0933
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.01 0.02 0.2851
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0045 0.0045
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0013 0.0101
Brugia malayi glutathione reductase 0.0084 0.0161 0.1336
Plasmodium falciparum importin beta, putative 0.0029 0.0027 0.1322
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0511 0.1202 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.005 0.0414
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0005 0.0044
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0027 0.0301
Brugia malayi TAR-binding protein 0.0135 0.0286 0.2382
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0129 0.038
Plasmodium vivax vivapain-2 0.0035 0.004 0.2159
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.006 0.006
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0008 0.0068
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.01 0.01
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0052 0.0666
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.02 0.2851
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0034 0.0102
Leishmania major cathepsin L-like protease 0.0035 0.004 0.0491
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.005 0.0414
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.005 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Entamoeba histolytica hypothetical protein 0.0144 0.0308 0.4339
Schistosoma mansoni patched 1 0.0043 0.006 0.0183
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0071 0.0587
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0008 0.0065
Echinococcus granulosus microtubule associated protein 2 0.134 0.3228 0.979
Echinococcus granulosus importin subunit beta 1 0.0029 0.0027 0.0082
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0052 0.0052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0027 0.0295
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.03 0.4336
Schistosoma mansoni ap endonuclease 0.0039 0.0052 0.0157
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0071 0.0129 0.038
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0027 0.1047
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0055 0.0166
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0013 0.0099
Trichomonas vaginalis glutaminase, putative 0.0277 0.0632 0.5233
Trypanosoma brucei protein kinase, putative 0.01 0.02 0.2851
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0055
Entamoeba histolytica acyl-coA synthetase, putative 0.0071 0.0129 0.1771
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.005 0.0414
Leishmania major importin beta-1 subunit, putative 0.0024 0.0013 0.0101
Brugia malayi Bromodomain containing protein 0.0039 0.005 0.0418
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.004 0.0479
Schistosoma mansoni alpha-glucosidase 0.0142 0.0303 0.0918
Loa Loa (eye worm) hypothetical protein 0.0053 0.0086 0.0711
Toxoplasma gondii exonuclease III APE 0.0039 0.0052 0.2336
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.07 0.5803
Giardia lamblia Fructose-bisphosphate aldolase 0.0305 0.07 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0129 0.1813
Echinococcus multilocularis tar DNA binding protein 0.0135 0.0286 0.0286
Loa Loa (eye worm) glutaminase 2 0.0277 0.0632 0.526
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.005 0.0414
Schistosoma mansoni hypothetical protein 0.0032 0.0034 0.0102
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.005 0.0151
Brugia malayi hypothetical protein 0.0144 0.0308 0.2559
Echinococcus granulosus thioredoxin glutathione reductase 0.0084 0.0162 0.0491
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0129 0.038
Onchocerca volvulus 0.0021 0.0007 0.0086
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0369 0.0856 0.2597
Plasmodium vivax glutathione reductase, putative 0.0084 0.0161 1
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0286 0.0868
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.004 0.004
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0007 0.0055
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0027 0.0267
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.0519 0.0519
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0011 0.0011
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0011 0.0034
Brugia malayi Bromodomain containing protein 0.0032 0.0033 0.0272
Brugia malayi Cathepsin L-like precursor 0.0035 0.004 0.0332
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.0684 1
Loa Loa (eye worm) oxidoreductase 0.0021 0.0007 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.004 0.0479
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.005 0.005
Entamoeba histolytica Ran family GTPase 0.0022 0.0008 0.0022
Schistosoma mansoni transcription factor LCR-F1 0.0144 0.0308 0.0933
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0007 0.0055
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0189 0.0417 0.3472
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.0144 0.0308 0.4339
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.01 0.0289
Onchocerca volvulus Cathepsin F homolog 0.0035 0.004 0.0515
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.07 0.5803
Brugia malayi Muscleblind-like protein 0.0298 0.0683 0.5681
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0011 0.0034
Brugia malayi P38 map kinase family protein 2 0.0123 0.0256 0.2132
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0414
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0027 0.0081
Schistosoma mansoni ran 0.0022 0.0008 0.0025
Entamoeba histolytica serine/threonine protein kinase, putative 0.0189 0.0417 0.5922
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0027 0.0062
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0027 0.0301
Leishmania major GTP-binding protein, putative 0.0022 0.0008 0.0022
Schistosoma mansoni hypothetical protein 0.0069 0.0124 0.0377
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.005 0.0151
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0192 0.0423 0.1288
Loa Loa (eye worm) hypothetical protein 0.01 0.0199 0.1659
Plasmodium vivax vivapain-2 0.0035 0.004 0.2159
Trypanosoma cruzi cysteine peptidase, putative 0.0035 0.004 0.0491
Echinococcus granulosus cathepsin l cysteine peptidase 0.0035 0.004 0.0121
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0082 0.068
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1346 0.3242 1
Brugia malayi Cathepsin L-like precursor 0.0023 0.0012 0.01
Echinococcus multilocularis protein patched 0.0043 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.01
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0012 0.0077
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0027 0.0062
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0123 0.0256 0.3685
Trypanosoma cruzi major cysteine proteinase, putative 0.0103 0.0208 0.2972
Brugia malayi glutaminase DH11.1 0.0277 0.0632 0.526
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0035 0.004 0.2159
Schistosoma mansoni bromodomain containing protein 0.0064 0.0112 0.034
Brugia malayi nuclear receptor NHR-88 0.0039 0.005 0.0414
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0045 0.0322
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0047 0.0141
Echinococcus multilocularis protein dispatched 1 0.0049 0.0075 0.0075
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0047 0.0387
Trichomonas vaginalis ran, putative 0.0022 0.0008 0.0013
Mycobacterium tuberculosis Probable dehydrogenase 0.0192 0.0423 0.1288
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0202 0.1684
Onchocerca volvulus 0.0039 0.005 0.0643
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0045 0.0322
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.005 0.0151
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0078 0.0222
Schistosoma mansoni microtubule-associated protein tau 0.134 0.3228 0.979
Echinococcus multilocularis muscleblind protein 1 0.0298 0.0683 0.0683
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0027 0.0295
Loa Loa (eye worm) ctsf protein 0.0035 0.004 0.0332
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0005 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0286 0.0868
Leishmania major cathepsin L-like protease 0.0035 0.004 0.0491
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.0684 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0203 0.0616
Echinococcus multilocularis geminin 0.1368 0.3297 0.3297
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0773 0.6414
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0027 0.0295
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0129 0.038
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.01 0.0304
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.01 0.02 0.1662
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0773 0.6414
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.0129 0.038
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.07 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0129 0.1077
Trypanosoma brucei hypothetical protein, conserved 0.0206 0.0457 0.6653
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0027 0.1299
Schistosoma mansoni coup transcription factor 0.0039 0.005 0.0151
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0086 0.0244
Echinococcus multilocularis mitogen activated protein kinase 0.01 0.02 0.02
Brugia malayi CHE-14 protein 0.0043 0.006 0.0501
Brugia malayi Cathepsin L-like precursor 0.0035 0.004 0.0332
Brugia malayi jmjC domain containing protein 0.0037 0.0047 0.0387
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0045 0.0375
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.004 0.0121
Leishmania major cathepsin L-like protease 0.0035 0.004 0.0491
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.004 0.0278
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.005 0.0414
Mycobacterium tuberculosis Probable reductase 0.0192 0.0423 0.1288
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.01 0.0289
Entamoeba histolytica hypothetical protein 0.0144 0.0308 0.4339
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0332
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.0457 0.6653
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Onchocerca volvulus 0.0028 0.0025 0.0322
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0071 0.0214
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0044
Schistosoma mansoni hypothetical protein 0.0312 0.0718 0.2178
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0129 0.038
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0013 0.0021
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0052 0.0373
Loa Loa (eye worm) hypothetical protein 0.0053 0.0086 0.0711
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0225
Loa Loa (eye worm) hypothetical protein 0.0122 0.0254 0.2111
Giardia lamblia PHD finger protein 15 0.0029 0.0027 0.0271
Trypanosoma cruzi polo-like protein kinase, putative 0.0189 0.0417 0.6063
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0129 0.1077
Leishmania major cysteine peptidase A (CPA) 0.0035 0.004 0.0491
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0027 0.1299
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0501
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0044 0.0044
Plasmodium falciparum thioredoxin reductase 0.0084 0.0161 1
Echinococcus multilocularis cysteine protease 0.0035 0.004 0.004
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0144 0.0308 0.0933
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0008 0.0065
Brugia malayi PHD-finger family protein 0.0025 0.0017 0.0143
Echinococcus granulosus expressed conserved protein 0.0094 0.0185 0.056
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0202 0.1684
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0027 0.0295
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0144 0.0308 0.0308
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0141 0.0428
Brugia malayi Cathepsin L-like precursor 0.0035 0.004 0.0332
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0189 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0414
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0027 0.1299
Echinococcus granulosus zinc finger protein 0.002 0.0004 0.0012
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0027 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Echinococcus multilocularis mitogen activated protein kinase 3 0.01 0.02 0.02
Plasmodium vivax importin-beta 2, putative 0.0029 0.0027 0.1322
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0199 0.0605
Echinococcus granulosus tar DNA binding protein 0.0135 0.0286 0.0868
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.07 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.0319 0.0967
Toxoplasma gondii cathepsin CPL 0.0035 0.004 0.1721
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.005 0.0151
Echinococcus granulosus mitogen activated protein kinase 11 0.0123 0.0256 0.0777
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0359 0.0359
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0052 0.063
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0052 0.0666
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0045 0.0375
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0035 0.004 0.2159
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0511 0.1202 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.005 0.0151
Echinococcus multilocularis mitogen activated protein kinase 11 0.0123 0.0256 0.0256
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.0268 0.0814
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0013 0.0021
Loa Loa (eye worm) hypothetical protein 0.0052 0.0084 0.0697
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0027 0.0027
Brugia malayi Cathepsin L-like precursor 0.0023 0.0012 0.01
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.005 0.0414
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0013 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.005 0.0414
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Trypanosoma cruzi cysteine peptidase, putative 0.0132 0.0277 0.3987
Trypanosoma brucei polo-like protein kinase 0.0189 0.0417 0.6063
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.012 0.0249 0.3575
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0052 0.293
Onchocerca volvulus Cathepsin L homolog 0.0035 0.004 0.0515
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0013 0.0057
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0005 0.0016
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0192 0.0423 0.1288
Trichomonas vaginalis CMGC family protein kinase 0.01 0.02 0.1616
Onchocerca volvulus 0.0096 0.0189 0.2441
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0588
Leishmania major trypanothione reductase 0.0084 0.0161 0.2273
Brugia malayi cathepsin L-like precursor 0.0023 0.0012 0.01
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0027 0.1299
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.005 0.0151
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0123 0.0256 0.3685
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0369 0.0856 0.7122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Trypanosoma brucei glucosidase, putative 0.0037 0.0045 0.0567
Schistosoma mansoni hypothetical protein 0.0041 0.0056 0.0171
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.0304 0.0922
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0045 0.0554
Schistosoma mansoni glutaminase 0.0277 0.0632 0.1918
Loa Loa (eye worm) thioredoxin reductase 0.0084 0.0161 0.1336
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0005 0.0005
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0045 0.0322
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0189 0.0573
Onchocerca volvulus 0.0035 0.004 0.0515
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0045 0.0322
Brugia malayi nuclear hormone receptor 0.0039 0.005 0.0414
Brugia malayi Importin beta-1 subunit 0.0029 0.0027 0.0225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.004 0.0278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0129 0.1771
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0027 0.0223
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0417 0.3436
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0029 0.1136
Onchocerca volvulus 0.0021 0.0007 0.0086
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0213 0.0475 0.1449
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.01 0.1382
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0027 0.1047
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0007 0.0055
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0339 0.1028
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0008 0.0068
Brugia malayi serine/threonine-protein kinase plk-2 0.0189 0.0417 0.3472
Loa Loa (eye worm) hypothetical protein 0.0053 0.0086 0.0711
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.004 0.0278
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.02 0.2851
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0027 0.0167
Schistosoma mansoni kinase 0.0097 0.0192 0.0582
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0123 0.0256 0.3685
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.01 0.0289
Loa Loa (eye worm) RNA binding protein 0.0135 0.0286 0.2382
Brugia malayi hypothetical protein 0.002 0.0005 0.0044
Brugia malayi Cathepsin L-like precursor 0.0035 0.004 0.0332
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0123 0.0256 0.2132
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.005 0.0151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.0286 0.2382
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0464 0.3864
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.01
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.01 0.0289
Trypanosoma cruzi trypanothione reductase, putative 0.0084 0.0161 0.2273
Schistosoma mansoni thyroid hormone receptor 0.0167 0.0363 0.11
Loa Loa (eye worm) hypothetical protein 0.0053 0.0086 0.0711
Onchocerca volvulus Huntingtin homolog 0.0122 0.0254 0.3281
Brugia malayi ecdysteroid receptor 0.0039 0.005 0.0414
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.0359 0.2985
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0044
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.0718 0.5973
Mycobacterium tuberculosis Probable oxidoreductase 0.0213 0.0475 0.1449
Brugia malayi hypothetical protein 0.002 0.0005 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0369 0.0856 0.2597
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0213 0.0475 0.1449
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.01 0.0304
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.0555 0.462
Trichomonas vaginalis set domain proteins, putative 0.0237 0.0535 0.4418
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.006 0.0183
Loa Loa (eye worm) hypothetical protein 0.0071 0.0129 0.1077
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0071 0.0071
Echinococcus multilocularis microtubule associated protein 2 0.134 0.3228 0.3228
Trypanosoma cruzi cysteine peptidase, putative 0.0132 0.0277 0.3987
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.005 0.0643
Leishmania major cathepsin L-like protease 0.0035 0.004 0.0491
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.004 0.0278
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0013 0.0021
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0052 0.0157
Schistosoma mansoni hypothetical protein 0.0041 0.0056 0.0171
Leishmania major cathepsin L-like protease 0.0035 0.004 0.0491
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0086 0.5122
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0286 0.0868
Schistosoma mansoni alpha-glucosidase 0.0142 0.0303 0.0918
Loa Loa (eye worm) hypothetical protein 0.0298 0.0683 0.5681
Echinococcus multilocularis muscleblind protein 0.0298 0.0683 0.0683
Echinococcus granulosus GPCR family 2 0.0032 0.0034 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.004 0.0278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.005 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.1202 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.0304 0.0304
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0027 0.0295
Loa Loa (eye worm) cysteine protease 0.0035 0.004 0.0332
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0005 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.004 0.0278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.01
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0008 0.0022
Loa Loa (eye worm) fibroinase 0.0035 0.004 0.0332
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0045 0.0567
Brugia malayi RNA, U transporter 1 0.0083 0.0159 0.132
Mycobacterium ulcerans transcriptional regulator 0.1346 0.3242 1
Brugia malayi hypothetical protein 0.0231 0.0519 0.4318
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.005 0.0414
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.005 0.0414
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0027 0.0062
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.005 0.0151
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0414
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0044
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.01 0.02 0.2851
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0013 0.0057
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.01 0.0833
Schistosoma mansoni nuclear hormone receptor 0.0039 0.005 0.0151
Entamoeba histolytica cysteine protease, putative 0.0035 0.004 0.0479
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0034 0.028
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0027 0.1035
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0058 0.0759
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0507
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0129 0.038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0369 0.0856 0.2597
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0417 0.3436
Mycobacterium ulcerans glutaminase 0.0277 0.0632 0.1933
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0052 0.065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0369 0.0856 0.2597
Leishmania major cathepsin L-like protease 0.0132 0.0277 0.3987
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0029 0.0087
Echinococcus granulosus cathepsin l1 0.0023 0.0012 0.0036
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0058 0.0759
Loa Loa (eye worm) hypothetical protein 0.0298 0.0683 0.5681
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.004 0.004
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.005 0.0414
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0417 0.3436
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.01 0.0304
Schistosoma mansoni hypothetical protein 0.0041 0.0056 0.0171
Giardia lamblia Kinase, PLK 0.0189 0.0417 0.5913
Loa Loa (eye worm) hypothetical protein 0.005 0.0078 0.0647
Echinococcus granulosus muscleblind protein 0.0298 0.0683 0.2071
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0027 0.1035
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.005 0.0151
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0223
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0055
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0773 0.6414
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.005 0.005
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0013 0.0013
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.005 0.0414
Mycobacterium ulcerans hypothetical protein 0.0024 0.0013 0.0021
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0034 0.0034
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1346 0.3242 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0045 0.0322
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.005 0.0151
Trichomonas vaginalis CMGC family protein kinase 0.01 0.02 0.1616
Schistosoma mansoni hypothetical protein 0.1368 0.3297 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0007 0.0055
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.0319 0.0967
Leishmania major hypothetical protein, conserved 0.0206 0.0457 0.6653
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0045 0.199
Echinococcus granulosus FTZ F1 alpha 0.0039 0.005 0.0151
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.0286 0.2382
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.005 0.0414
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.01 0.02 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0078 0.0222
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0122 0.0254 0.2111
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.01 0.02 0.2851
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.03 0.4336
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0027 0.0027
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0007 0.002
Plasmodium falciparum thioredoxin reductase 0.0029 0.0027 0.1299
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0032 0.0034 0.028
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0047 0.0141
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0008 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.0817 0.6783
Echinococcus multilocularis peregrin 0.0032 0.0033 0.0033
Brugia malayi Bromodomain containing protein 0.0076 0.0141 0.1172
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0052 0.0377
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.07 0.5803
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0035 0.004 0.0332
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.005 0.0414
Echinococcus granulosus cathepsin L cysteine proteinase 0.0035 0.004 0.0121
Brugia malayi RNA binding protein 0.0135 0.0286 0.2382
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0027 0.0295
Schistosoma mansoni hypothetical protein 0.0029 0.0027 0.0081
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0369 0.0856 0.2597
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0007 0.002
Loa Loa (eye worm) glutaminase 0.0277 0.0632 0.526
Onchocerca volvulus 0.0071 0.0129 0.1674
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0129 0.1077
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0027 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Giardia lamblia Kinase, CMGC MAPK 0.01 0.02 0.2769
Plasmodium falciparum cysteine proteinase falcipain 3 0.0035 0.004 0.2159
Echinococcus multilocularis cysteine protease 0.0035 0.004 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.1202 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0008 0.0008
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0013 0.0021
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0044
Brugia malayi steroid hormone receptor 0.0039 0.005 0.0414
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0071 0.0214
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0007 0.0055
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0103 0.0313
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0027 0.0295
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0086 0.0244
Onchocerca volvulus Serine\/threonine kinase homolog 0.0189 0.0417 0.5397
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.004 0.0278
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.0359 0.1088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.07 0.5803
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0084 0.0161 0.0476
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0007 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.1202 1
Onchocerca volvulus Cathepsin L homolog 0.0035 0.004 0.0515
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.005 0.005
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0045 0.0567
Loa Loa (eye worm) hypothetical protein 0.0071 0.0129 0.1077
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.1202 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0189 0.0417 0.1266
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.01 0.02 0.2851
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.1202 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0058 0.0759
Schistosoma mansoni hypothetical protein 0.0128 0.0268 0.0814
Echinococcus granulosus mitogen activated protein kinase 3 0.01 0.02 0.0606
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0012 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.01 0.1379
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.005 0.005
Mycobacterium ulcerans hypothetical protein 0.0024 0.0013 0.0021
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0013 0.0099
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.005 0.005
Echinococcus granulosus geminin 0.1368 0.3297 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0027 0.0295
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.005 0.0414
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.07 0.5803
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.005 0.0414
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0045 0.0322
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0027 0.1314
Brugia malayi MH2 domain containing protein 0.0246 0.0555 0.462
Mycobacterium ulcerans hypothetical protein 0.0071 0.0129 0.038
Echinococcus multilocularis thioredoxin glutathione reductase 0.0084 0.0162 0.0162
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0052 0.0377
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.0684 1
Brugia malayi Cathepsin L-like precursor 0.0035 0.004 0.0332
Brugia malayi PHD-finger family protein 0.0029 0.0027 0.0223
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0027 0.0295
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0414
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0008 0.0022
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0027 0.0167
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0414
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.004 0.0278
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.07 0.5803
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0078 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.005 0.0414
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0773 0.6414
Onchocerca volvulus 0.0035 0.004 0.0515
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0042 0.0042
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0027 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.01 0.02 0.0606
Loa Loa (eye worm) STAT protein 0.016 0.0346 0.288
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0192 0.0423 0.1288
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0417 0.3436
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.0457 0.6653
Schistosoma mansoni hypothetical protein 0.0021 0.0007 0.002
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0052 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0129 0.1771
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0071 0.0129 0.038
Schistosoma mansoni survival motor neuron protein 0.0047 0.0071 0.0214
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0013 0.0041
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0058 0.0759
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.005 0.0643
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0034 0.0102
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0414
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0129 0.038
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.004 0.0278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Trichomonas vaginalis CMGC family protein kinase 0.01 0.02 0.1616
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0101 0.0202 0.1684
Echinococcus granulosus cathepsin l1 0.0035 0.004 0.0121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0013 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.004 0.0278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Onchocerca volvulus 0.0035 0.004 0.0515
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0005 0.0016
Brugia malayi nuclear receptor RXR 0.002 0.0005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0053 0.0086 0.0711
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0027 0.0081
Plasmodium falciparum glutathione reductase 0.0029 0.0027 0.1299
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0369 0.0856 0.7122
Onchocerca volvulus 0.0035 0.004 0.0515
Echinococcus granulosus mitogen activated protein kinase 0.01 0.02 0.0606
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1346 0.3242 1
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0007 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.004 0.0278
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0129 0.1813
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0186 0.1499
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0044
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0129 0.038
Echinococcus multilocularis mitogen activated protein kinase 14 0.0123 0.0256 0.0256
Onchocerca volvulus 0.0035 0.004 0.0515
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.0319 0.0967
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0012 0.01
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0052 0.0139
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0199 0.0199
Schistosoma mansoni hypothetical protein 0.0032 0.0034 0.0102
Schistosoma mansoni zinc finger protein 0.002 0.0004 0.0012
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.01 0.02 0.2851
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.005 0.0414
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.03 0.4336
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.005 0.0414
Schistosoma mansoni hypothetical protein 0.0055 0.009 0.0272
Trypanosoma brucei trypanothione reductase 0.0084 0.0161 0.2273
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0071 0.0129 0.038
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0189 0.0417 0.6063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0369 0.0856 0.0856
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0044 0.0135
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0029 0.0087
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0055 0.0055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.07 0.5803
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0027 0.0221
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.004 0.0332
Schistosoma mansoni hypothetical protein 0.1368 0.3297 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.004 0.0278
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0052 0.0666
Schistosoma mansoni ap endonuclease 0.0039 0.0052 0.0157
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0013 0.0099
Echinococcus granulosus mitogen activated protein kinase 14 0.0123 0.0256 0.0777
Onchocerca volvulus 0.0237 0.0535 0.6914
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0047 0.0141
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.005 0.0414
Entamoeba histolytica hypothetical protein 0.0144 0.0308 0.4339
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0773 0.6414
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0417 0.3436
Toxoplasma gondii hypothetical protein 0.0048 0.0073 0.3441
Schistosoma mansoni hypothetical protein 0.0032 0.0034 0.0102
Onchocerca volvulus 0.0023 0.0012 0.0155
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0069 0.0124 0.1034
Echinococcus multilocularis mitogen activated protein kinase 14 0.0123 0.0256 0.0256
Onchocerca volvulus 0.0035 0.004 0.0515
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0103 0.0855
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0189 0.0189
Echinococcus granulosus snurportin 1 0.0312 0.0718 0.2178
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0199 0.2779
Brugia malayi Pre-SET motif family protein 0.003 0.0029 0.0238
Loa Loa (eye worm) hypothetical protein 0.0231 0.0519 0.4318
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0277 0.3987
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.005 0.0414
Brugia malayi Pre-SET motif family protein 0.0208 0.0464 0.3864
Mycobacterium ulcerans TetR family transcriptional regulator 0.1346 0.3242 1
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.1202 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0192 0.0423 0.1288
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0027 0.0295
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0286 0.0868
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.01 0.0289
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0008 0.0078
Brugia malayi MAP kinase sur-1 0.01 0.02 0.1662
Plasmodium vivax thioredoxin reductase, putative 0.0084 0.0161 1
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.0684 1
Echinococcus multilocularis snurportin 1 0.0312 0.0718 0.0718
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.0555 0.462
Brugia malayi Cathepsin L-like precursor 0.0035 0.004 0.0332
Leishmania major cathepsin L-like protease 0.0132 0.0277 0.3987
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0417 0.3436
Echinococcus multilocularis expressed conserved protein 0.0094 0.0185 0.0185
Trypanosoma cruzi cruzipain precursor, putative 0.0132 0.0277 0.3987
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0045 0.0554
Loa Loa (eye worm) hypothetical protein 0.0041 0.0056 0.0468

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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