Detailed information for compound 576017

Basic information

Technical information
  • TDR Targets ID: 576017
  • Name: methyl (2E,3Z,5E)-6-(4-chloro-3-methoxy-pheny l)-2-(methoxymethylene)-3-methyl-hexa-3,5-die noate
  • MW: 322.783 | Formula: C17H19ClO4
  • H donors: 0 H acceptors: 1 LogP: 4.47 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO/C=C(\C(=C\C=Cc1ccc(c(c1)OC)Cl)\C)/C(=O)OC
  • InChi: 1S/C17H19ClO4/c1-12(14(11-20-2)17(19)22-4)6-5-7-13-8-9-15(18)16(10-13)21-3/h5-11H,1-4H3/b7-5+,12-6-,14-11+
  • InChiKey: ZDIQYKMDNQULMX-PJUQCDRASA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2E,3Z,5E)-6-(4-chloro-3-methoxyphenyl)-2-(methoxymethylene)-3-methylhexa-3,5-dienoic acid methyl ester
  • methyl (2E,3Z,5E)-6-(4-chloro-3-methoxy-phenyl)-2-(methoxymethylidene)-3-methyl-hexa-3,5-dienoate
  • (2E,3Z,5E)-6-(4-chloro-3-methoxy-phenyl)-2-(methoxymethylene)-3-methyl-hexa-3,5-dienoic acid methyl ester
  • methyl (2E,3Z,5E)-6-(4-chloro-3-methoxyphenyl)-2-(methoxymethylidene)-3-methylhexa-3,5-dienoate
  • strobilurin B
  • 65105-52-4

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0224 0.332
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0009 0.0146 0.0123
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0489 0.7699
Schistosoma mansoni hypothetical protein 0.0054 0.1155 0.2281
Loa Loa (eye worm) RecQ helicase 0.0024 0.0489 0.0467
Trichomonas vaginalis CMGC family protein kinase 0.0028 0.0586 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0004 0.0043 0.0055
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0004 0.0041 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.0375 0.0352
Echinococcus multilocularis ubiquitin specific protease 41 0.0022 0.0448 0.0728
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0003 0.0023 0.0046
Loa Loa (eye worm) hypothetical protein 0.0004 0.0043 0.002
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0004 0.0041 0.5
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0022 0.0448 0.0728
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.0489 0.0799
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0448 0.0426
Echinococcus multilocularis 0.0004 0.0041 0.0031
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0489 0.8291
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0004 0.0043 0.002
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0489 0.0467
Schistosoma mansoni calpain-7 (C02 family) 0.0003 0.0023 0.0046
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0003 0.0023 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0004 0.0041 0.5
Schistosoma mansoni cpg binding protein 0.0017 0.0328 0.0648
Brugia malayi photoreceptor-specific nuclear receptor 0.0004 0.0043 0.002
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0489 0.0467
Schistosoma mansoni hypothetical protein 0.0009 0.0146 0.0288
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0004 0.0041 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.0146 0.0123
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0004 0.003 0.0119
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0004 0.0041 0.0018
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0004 0.0043 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0004 0.0041 0.5
Schistosoma mansoni cpg binding protein 0.0016 0.0308 0.0608
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0489 0.8291
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0224 0.0202
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0004 0.0043 0.002
Toxoplasma gondii cytochrome p450 superfamily protein 0.0004 0.0041 0.03
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.0489 0.8291
Schistosoma mansoni jun-related protein 0.0038 0.0802 0.1584
Schistosoma mansoni ubiquitin-specific peptidase 4 (C19 family) 0.0003 0.0023 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0224 0.0202
Leishmania major hypothetical protein, conserved 0.0167 0.3703 0.3689
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0004 0.0043 0.0085
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0004 0.0041 0.5
Echinococcus multilocularis GPCR, family 2 0.0009 0.0146 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.003 0.0119
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0448 0.7557
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0224 0.0443
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0004 0.0043 0.0034
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0004 0.0043 0.0034
Echinococcus multilocularis jun protein 0.0047 0.0999 0.167
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0004 0.0041 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0004 0.0043 0.002
Giardia lamblia Kinase, CMGC MAPK 0.0028 0.0586 1
Schistosoma mansoni DNA helicase recq5 0.0024 0.0489 0.0967
Loa Loa (eye worm) hypothetical protein 0.0263 0.5862 0.5853
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0004 0.0041 0.5
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0004 0.0041 0.5
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0167 0.3703 0.3689
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0004 0.0041 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0028 0.0586 1
Leishmania major cytochrome p450-like protein 0.0004 0.0041 0.0018
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0004 0.0041 0.5
Schistosoma mansoni ubiquitin-specific peptidase 46 (C19 family) 0.0003 0.0023 0.0046
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0009 0.0146 0.021
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0448 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0448 0.7557
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.003 0.0119
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0489 0.0467
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0003 0.0023 0.0046
Onchocerca volvulus 0.0037 0.0773 0.2038
Echinococcus granulosus cytochrome P450 2K1 0.0004 0.0041 0.0031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0.003 0.0119
Schistosoma mansoni thyroid hormone receptor 0.0004 0.0043 0.0085
Echinococcus multilocularis mitogen activated protein kinase 0.0028 0.0586 0.0963
Toxoplasma gondii histone lysine methyltransferase SET1 0.003 0.0629 1
Onchocerca volvulus 0.0167 0.3703 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0004 0.0043 0.0055
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0214 0.3146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0004 0.0043 0.002
Schistosoma mansoni DNA helicase recq1 0.0024 0.0489 0.0967
Brugia malayi hypothetical protein 0.0037 0.0773 0.0752
Echinococcus granulosus mitogen activated protein kinase 0.0028 0.0586 0.0963
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0004 0.0041 0.5
Trypanosoma cruzi Emopamil binding protein, putative 0.0167 0.3703 0.3689
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0009 0.0146 0.021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0028 0.0572 0.055
Schistosoma mansoni thyroid hormone receptor 0.0004 0.0043 0.0085
Brugia malayi Cytochrome P450 family protein 0.0004 0.0041 0.0018
Echinococcus granulosus cpg binding protein 0.0017 0.0328 0.0522
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0028 0.0586 0.0564
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0028 0.0586 0.0564
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0028 0.0586 0.0564
Brugia malayi small heat shock protein 0.0321 0.7171 0.7164
Trypanosoma brucei cytochrome P450, putative 0.0004 0.0041 0.0018
Loa Loa (eye worm) hypothetical protein 0.0004 0.0043 0.002
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0003 0.0023 0.0046
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0214 0.4087
Echinococcus multilocularis ecdysone induced protein 78C 0.0004 0.0043 0.0034
Schistosoma mansoni coup transcription factor 0.0004 0.0043 0.0085
Loa Loa (eye worm) hypothetical protein 0.0022 0.0448 0.0426
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0004 0.0043 0.002
Brugia malayi bZIP transcription factor family protein 0.0047 0.0999 0.0978
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0004 0.0043 0.0034
Echinococcus granulosus FTZ F1 alpha 0.0004 0.0043 0.0034
Loa Loa (eye worm) hypothetical protein 0.0004 0.0043 0.002
Schistosoma mansoni ubiquitin-specific peptidase 7 (C19 family) 0.0003 0.0023 0.0046
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0448 0.0426
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0004 0.0041 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0004 0.0043 0.002
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0004 0.0041 0.5
Onchocerca volvulus 0.0054 0.1155 0.3075
Echinococcus granulosus jun protein 0.0047 0.0999 0.167
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0005 0.006 0.0062
Schistosoma mansoni ubiquitin-specific peptidase 48 (C19 family) 0.0003 0.0023 0.0046
Echinococcus granulosus mitogen activated protein kinase 3 0.0028 0.0586 0.0963
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0113 0.2489 0.2472
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0047 0.0999 0.167
Leishmania major C-8 sterol isomerase-like protein 0.0447 1 1
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0489 0.8291
Loa Loa (eye worm) hypothetical protein 0.0045 0.097 0.0949
Trypanosoma brucei protein kinase, putative 0.0028 0.0586 0.0564
Loa Loa (eye worm) hypothetical protein 0.0321 0.7171 0.7164
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0004 0.0041 0.5
Schistosoma mansoni ubiquitin-specific peptidase 14 (C19 family) 0.0003 0.0023 0.0046
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0022 0.0448 0.0728
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0004 0.0041 0.5
Echinococcus multilocularis survival motor neuron protein 1 0.0263 0.5862 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0004 0.0041 0.0018
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0214 0.0422
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.003 0.0119
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0004 0.0043 0.002
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0004 0.0041 0.5
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0167 0.3703 0.3689
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0028 0.0586 0.0564
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0004 0.0038 0.0025
Trypanosoma brucei C-8 sterol isomerase, putative 0.0447 1 1
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0447 1 1
Echinococcus granulosus survival motor neuron protein 1 0.0263 0.5862 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0004 0.0043 0.0034
Schistosoma mansoni peptidase 0.0004 0.0029 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.003 0.0119
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0004 0.0041 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0004 0.0043 0.0085
Brugia malayi steroid hormone receptor 0.0004 0.0043 0.002
Brugia malayi Nuclear hormone receptor-like 1 0.0004 0.0043 0.002
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0004 0.0041 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0004 0.0043 0.002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0.003 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.003 0.0119
Echinococcus multilocularis cpg binding protein 0.0017 0.0328 0.0522
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0004 0.0041 0.5
Brugia malayi hypothetical protein 0.002 0.0398 0.0376
Brugia malayi Cytochrome P450 family protein 0.0004 0.0041 0.0018
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0004 0.0041 0.5
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0004 0.0038 0.0025
Brugia malayi Steroid receptor seven-up type 2 0.0004 0.0043 0.002
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0004 0.0041 0.5
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0004 0.0038 0.0025
Schistosoma mansoni survival motor neuron protein 0.0054 0.1155 0.2281
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0004 0.0043 0.002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0004 0.0043 0.002
Loa Loa (eye worm) cytochrome P450 0.0004 0.0041 0.0018
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0004 0.0043 0.0034
Loa Loa (eye worm) histone methyltransferase 0.0005 0.006 0.0036
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0489 0.0467
Echinococcus granulosus bloom syndrome protein 0.0024 0.0489 0.0799
Echinococcus granulosus mixed lineage leukemia protein mll 0.0004 0.0038 0.0025
Schistosoma mansoni hypothetical protein 0.0038 0.0802 0.1584
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0448 0.0426
Schistosoma mansoni cpg binding protein 0.0017 0.0328 0.0648
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0004 0.0041 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0004 0.0043 0.002
Schistosoma mansoni hypothetical protein 0.0009 0.0146 0.0288
Loa Loa (eye worm) CYP4Cod1 0.0004 0.0041 0.0018
Schistosoma mansoni transcription factor LCR-F1 0.002 0.0398 0.0787
Schistosoma mansoni hypothetical protein 0.0009 0.0146 0.0288
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0004 0.0041 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0004 0.0043 0.002
Loa Loa (eye worm) hypothetical protein 0.0228 0.5086 0.5075
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0224 0.0202
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0004 0.0041 0.0018
Loa Loa (eye worm) hypothetical protein 0.0004 0.0043 0.002
Echinococcus granulosus dnaJ subfamily B 0.0227 0.5063 0.8631
Loa Loa (eye worm) CXXC zinc finger family protein 0.0016 0.0308 0.0285
Loa Loa (eye worm) cytochrome P450 family protein 0.0004 0.0041 0.0018
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0034 0.071 0.1403
Loa Loa (eye worm) steroid hormone receptor 0.0004 0.0043 0.002
Schistosoma mansoni ubiquitin-specific peptidase 24 (C19 family) 0.0003 0.0023 0.0046
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0004 0.0043 0.0085
Entamoeba histolytica hypothetical protein 0.002 0.0398 0.8046
Echinococcus multilocularis dnaJ subfamily B 0.0227 0.5063 0.8631
Loa Loa (eye worm) hypothetical protein 0.0004 0.0043 0.002
Loa Loa (eye worm) hypothetical protein 0.0004 0.0043 0.002
Schistosoma mansoni calpain-7 (C02 family) 0.0003 0.0023 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0004 0.0043 0.002
Brugia malayi Cytochrome P450 family protein 0.0004 0.0041 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0586 0.1157
Entamoeba histolytica hypothetical protein 0.002 0.0398 0.8046
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0047 0.0999 0.167
Brugia malayi Cytochrome P450 family protein 0.0004 0.0041 0.0018
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0022 0.0448 0.0728
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0094 0.2063 0.3494
Schistosoma mansoni hypothetical protein 0.0227 0.5063 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0.003 0.0119
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0022 0.0448 0.0885
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0004 0.0043 0.0085
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0004 0.003 0.0119
Brugia malayi cytochrome P450 0.0004 0.0041 0.0018
Brugia malayi MAP kinase sur-1 0.0028 0.0586 0.0564
Trypanosoma cruzi cytochrome P450, putative 0.0004 0.0041 0.0018
Trypanosoma cruzi cytochrome P450, putative 0.0004 0.0041 0.0018
Echinococcus multilocularis FTZ F1 alpha 0.0004 0.0043 0.0034
Loa Loa (eye worm) cytochrome P450 family protein 0.0004 0.0041 0.0018
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0022 0.0448 0.9115
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0.003 0.0119
Loa Loa (eye worm) hypothetical protein 0.0012 0.0224 0.0202
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0022 0.0448 0.7557
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0004 0.0043 0.0034
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.0489 0.0799
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0004 0.0041 0.5
Schistosoma mansoni ubiquitin-specific peptidase 42 (C19 family) 0.0003 0.0023 0.0046
Brugia malayi nuclear hormone receptor 0.0004 0.0043 0.002
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0004 0.0041 0.5
Loa Loa (eye worm) hypothetical protein 0.0004 0.0043 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0004 0.0043 0.0034
Trichomonas vaginalis CMGC family protein kinase 0.0028 0.0586 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.002 0.0398 0.0643
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0004 0.0041 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0004 0.0043 0.002
Brugia malayi ecdysteroid receptor 0.0004 0.0043 0.002
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.1155 0.1134
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0022 0.0448 0.0728
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0028 0.0586 0.9287
Schistosoma mansoni ubiquitin-specific peptidase 45 (C19 family) 0.0003 0.0023 0.0046
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0489 1
Echinococcus granulosus ecdysone induced protein 78C 0.0004 0.0043 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0004 0.0043 0.002
Loa Loa (eye worm) hypothetical protein 0.0024 0.0489 0.0467
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0004 0.0041 0.5
Echinococcus multilocularis thyroid hormone receptor alpha 0.0004 0.0043 0.0034
Brugia malayi Latrophilin receptor protein 2 0.0009 0.0146 0.0123
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0004 0.0043 0.0034
Trichomonas vaginalis CMGC family protein kinase 0.0028 0.0586 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0004 0.0041 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0004 0.0043 0.0085
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0448 0.7557
Schistosoma mansoni ubiquitin-specific peptidase 16 (C19 family) 0.0003 0.0023 0.0046
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0004 0.0041 0.5
Echinococcus granulosus ubiquitin specific protease 41 0.0022 0.0448 0.0728
Loa Loa (eye worm) latrophilin receptor protein 2 0.0009 0.0146 0.0123
Schistosoma mansoni ubiquitin-specific peptidase 10 (C19 family) 0.0003 0.0023 0.0046
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0003 0.0023 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0004 0.0043 0.002
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0004 0.0041 0.0018
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.0489 0.0799
Treponema pallidum ATP-dependent DNA helicase 0.0012 0.0224 0.5
Loa Loa (eye worm) hypothetical protein 0.0447 1 1
Brugia malayi F/Y-rich N-terminus family protein 0.0005 0.0058 0.0035
Mycobacterium leprae putative cytochrome p450 0.0004 0.0041 0.5
Trichomonas vaginalis helicase, putative 0.0004 0.003 0.0119
Trypanosoma cruzi Emopamil binding protein, putative 0.0167 0.3703 0.3689
Schistosoma mansoni RAR-like nuclear receptor 0.0004 0.0043 0.0085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0004 0.0043 0.0034
Schistosoma mansoni cytochrome P450 0.0004 0.0041 0.0082
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0004 0.0041 0.5
Loa Loa (eye worm) hypothetical protein 0.0113 0.2489 0.2472
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0489 0.0467
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0028 0.0586 0.0564
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.0489 1
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.003 0.0119
Onchocerca volvulus Bile acid receptor homolog 0.0004 0.0043 0.0055
Onchocerca volvulus 0.0016 0.0308 0.0773
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0224 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0038 0.0074
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0004 0.0043 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0004 0.0043 0.002
Echinococcus granulosus GPCR family 2 0.0009 0.0146 0.021
Schistosoma mansoni hypothetical protein 0.0019 0.0375 0.074
Schistosoma mansoni nuclear hormone receptor 0.0004 0.0043 0.0085
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0005 0.006 0.0062
Brugia malayi latrophilin 2 splice variant baaae 0.0019 0.0375 0.0352
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0004 0.0041 0.5
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0489 0.7699
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0489 0.0467
Leishmania major cytochrome p450-like protein 0.0004 0.0041 0.0018
Brugia malayi CXXC zinc finger family protein 0.0016 0.0308 0.0285
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0004 0.0043 0.0034
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0004 0.0041 0.5
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0028 0.0586 0.0564
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0004 0.0043 0.002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0.003 0.0119
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0004 0.0041 0.5
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.0489 0.0799
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.003 0.0119
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0004 0.0041 0.5
Entamoeba histolytica hypothetical protein 0.002 0.0398 0.8046
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0489 0.0799
Schistosoma mansoni hypothetical protein 0.002 0.0398 0.0787
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0489 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0004 0.0041 0.5
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0028 0.0586 0.0564
Mycobacterium leprae Conserved hypothetical protein 0.0004 0.0041 0.5
Schistosoma mansoni family C19 unassigned peptidase (C19 family) 0.0003 0.0023 0.0046
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0489 0.0467
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0028 0.0586 0.0564
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0022 0.0448 0.0426
Leishmania major cytochrome p450-like protein 0.0004 0.0041 0.0018
Entamoeba histolytica hypothetical protein 0.002 0.0398 0.8046
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.003 0.0119
Schistosoma mansoni retinoic acid receptor RXR 0.0004 0.0043 0.0085
Schistosoma mansoni ubiquitin-specific peptidase 30 (C19 family) 0.0003 0.0023 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0004 0.0041 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0004 0.0043 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0004 0.0043 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.003 0.0119
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0004 0.0041 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0.003 0.0119
Schistosoma mansoni hypothetical protein 0.0009 0.0146 0.0288
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.002 0.0398 0.0643
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0004 0.0041 0.5
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0004 0.0041 0.5
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0004 0.0041 0.0018
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0094 0.2063 0.3494
Loa Loa (eye worm) hypothetical protein 0.0004 0.0043 0.002
Schistosoma mansoni hypothetical protein 0.0003 0.0023 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0004 0.0043 0.002
Loa Loa (eye worm) cytochrome P450 family protein 0.0004 0.0041 0.0018
Echinococcus multilocularis mitogen activated protein kinase 3 0.0028 0.0586 0.0963
Onchocerca volvulus 0.0004 0.0043 0.0055
Schistosoma mansoni ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold 0.0003 0.0023 0.0046
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0022 0.0448 0.0885
Schistosoma mansoni hypothetical protein 0.0004 0.0041 0.0082
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0004 0.0043 0.0034
Brugia malayi hypothetical protein 0.0263 0.5862 0.5853
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0004 0.0041 0.5
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0012 0.0214 0.9478
Trypanosoma brucei Emopamil binding protein, putative 0.0167 0.3703 0.3689
Schistosoma mansoni ubiquitin-specific peptidase 22 (C19 family) 0.0003 0.0023 0.0046
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0167 0.3703 0.3689
Schistosoma mansoni steroid hormone receptor ad4bp 0.0004 0.0043 0.0085
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0224 0.4312
Brugia malayi nuclear receptor NHR-88 0.0004 0.0043 0.002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0028 0.0572 0.055

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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