Detailed information for compound 592864

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 364.441 | Formula: C21H24N4O2
  • H donors: 1 H acceptors: 3 LogP: 3.71 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cccc(c1)n1c(=O)c2c(n1CC(=O)NC1CCCC1)nccc2
  • InChi: 1S/C21H24N4O2/c1-2-15-7-5-10-17(13-15)25-21(27)18-11-6-12-22-20(18)24(25)14-19(26)23-16-8-3-4-9-16/h5-7,10-13,16H,2-4,8-9,14H2,1H3,(H,23,26)
  • InChiKey: GDLKBLHGFYBFAG-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0024 0.0543
Echinococcus granulosus rhodopsin orphan GPCR 0.0195 0.0337 0.0386
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0004 0.0004
Schistosoma mansoni sodium-dependent amino acid transporter 0.0195 0.0338 0.0814
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0004 0.0004
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0048 0.0053
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0195 0.0337 0.0386
Echinococcus multilocularis rhodopsin orphan GPCR 0.0195 0.0337 0.0386
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.017 0.0408
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0195 0.0337 0.0386
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0004 0.0175
Loa Loa (eye worm) hypothetical protein 0.0031 0.0035 0.006
Schistosoma mansoni thyroid hormone receptor 0.002 0.0015 0.0033
Onchocerca volvulus 0.0014 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0106 0.0253
Echinococcus multilocularis rhodopsin orphan GPCR 0.0195 0.0337 0.0386
Echinococcus granulosus tm gpcr rhodopsin 0.4712 0.8691 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0195 0.0337 0.0386
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0048 0.1107
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0015 0.0033
Loa Loa (eye worm) hypothetical protein 0.0029 0.0032 0.0055
Onchocerca volvulus 0.0195 0.0338 0.0894
Brugia malayi sulfakinin receptor protein 0.0195 0.0337 0.0337
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0093 0.015 0.0171
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0018 0.0018
Plasmodium vivax SET domain protein, putative 0.0031 0.0035 0.0979
Loa Loa (eye worm) hypothetical protein 0.0029 0.0032 0.0055
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0015 0.0016
Brugia malayi 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 0.0063 0.0094 0.0094
Echinococcus granulosus glutamate receptor subunit protein glur 0.0038 0.0048 0.0053
Brugia malayi Receptor family ligand binding region containing protein 0.0029 0.0032 0.0031
Loa Loa (eye worm) neuropeptide F receptor 0.0195 0.0337 0.0602
Loa Loa (eye worm) hypothetical protein 0.0195 0.0338 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0046 0.1054
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0195 0.0338 0.0387
Brugia malayi hypothetical protein 0.0195 0.0338 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0006 0.0134
Schistosoma mansoni hypothetical protein 0.0195 0.0337 0.0812
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0038 0.0048 0.0053
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0014
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0195 0.0337 0.0812
Onchocerca volvulus 0.0195 0.0337 0.0892
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0004 0.0123
Echinococcus granulosus alpha 1A adrenergic receptor 0.0195 0.0337 0.0386
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0015 0.0033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.004 0.1944
Brugia malayi Doublecortin family protein 0.002 0.0015 0.0015
Brugia malayi Melibiase family protein 0.0069 0.0106 0.0106
Echinococcus granulosus neuropeptides capa receptor 0.0195 0.0337 0.0386
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0041 0.095
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0123 0.0204 0.0233
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.0184 0.8887
Plasmodium falciparum amino acid transporter, putative 0.0195 0.0338 1
Loa Loa (eye worm) oxidoreductase 0.0014 0.0004 0.0004
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0004 0.0175
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0033 0.0761
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0005 0.0004
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0004 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0015 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0015 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0004 0.0123
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0018
Schistosoma mansoni sodium/chloride dependent transporter 0.1002 0.1831 0.4426
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0009 0.0215
Echinococcus multilocularis receptor type guanylyl cyclase 0.0029 0.0032 0.0035
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.0184 0.8887
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0066 0.3796
Echinococcus multilocularis fmrfamide receptor 0.0195 0.0337 0.0386
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0106 0.0253
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0037 0.0036
Onchocerca volvulus 0.002 0.0015 0.0036
Schistosoma mansoni opsin-like receptor 0.0195 0.0337 0.0812
Chlamydia trachomatis glutamine binding protein 0.0058 0.0085 0.2299
Echinococcus multilocularis neuropeptides capa receptor 0.0195 0.0337 0.0386
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0046 0.008
Echinococcus granulosus survival motor neuron protein 1 0.0477 0.086 0.0988
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0004
Echinococcus multilocularis G-protein coupled receptor, putative 0.0195 0.0337 0.0386
Echinococcus multilocularis neuropeptide s receptor 0.0195 0.0337 0.0386
Brugia malayi vesicular acetylcholine transporter unc-17 0.2049 0.3766 0.3765
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0066 0.0066
Brugia malayi G protein-coupled receptor 0.0195 0.0337 0.0337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0063 0.1463
Loa Loa (eye worm) hypothetical protein 0.0195 0.0338 0.0603
Schistosoma mansoni hypothetical protein 0.0097 0.0158 0.0378
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0158 0.0157
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0015 0.0016
Brugia malayi Dopamine receptor protein 2 0.0195 0.0337 0.0337
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.0207 1
Schistosoma mansoni amine GPCR 0.0195 0.0337 0.0812
Loa Loa (eye worm) hypothetical protein 0.1002 0.1831 0.3274
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0005 0.0004
Echinococcus granulosus biogenic amine 5HT receptor 0.2248 0.4134 0.4756
Leishmania major trypanothione reductase 0.0049 0.0068 0.012
Echinococcus granulosus tm gpcr rhodopsin 0.0195 0.0337 0.0386
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0096 0.0155 0.0176
Loa Loa (eye worm) norepinephrine transporter 0.0195 0.0338 0.0603
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.0207 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0063 0.3631
Loa Loa (eye worm) hypothetical protein 0.3035 0.5589 1
Mycobacterium ulcerans hypothetical protein 0.0048 0.0066 0.32
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0004 0.0123
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0048 0.0047
Echinococcus multilocularis g protein coupled receptor 0.0195 0.0337 0.0386
Onchocerca volvulus 0.002 0.0015 0.0036
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0035 0.0038
Schistosoma mansoni amine GPCR 0.0195 0.0337 0.0812
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0014
Schistosoma mansoni biogenic amine (5HT) receptor 0.2248 0.4134 1
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0195 0.0338 0.0338
Echinococcus multilocularis somatostatin receptor 0.0195 0.0337 0.0386
Echinococcus granulosus allatostatin A receptor 0.0195 0.0337 0.0386
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0035 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0063 0.1463
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0004 0.0002
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0004 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0024 0.0543
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0073 0.0113 0.0269
Schistosoma mansoni polycystin 1-related 0.002 0.0015 0.0033
Onchocerca volvulus 0.0195 0.0337 0.0892
Echinococcus multilocularis allatostatin A receptor 0.0195 0.0337 0.0386
Loa Loa (eye worm) hypothetical protein 0.0477 0.086 0.1538
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0015 0.0016
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0195 0.0337 0.0386
Echinococcus granulosus metabotropic glutamate receptor 2 0.0029 0.0032 0.0035
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0041 0.095
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0035 0.0038
Loa Loa (eye worm) hypothetical protein 0.0029 0.0032 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0195 0.0337 0.0386
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0093 0.015 0.0171
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Echinococcus granulosus neuropeptides capa receptor 0.0195 0.0337 0.0386
Trichomonas vaginalis 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative 0.0103 0.0168 0.3906
Brugia malayi hypothetical protein 0.0477 0.086 0.086
Echinococcus granulosus GPCR family 2 0.0032 0.0037 0.004
Schistosoma mansoni biogenic amine receptor 0.0195 0.0337 0.0812
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0015 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0024 0.0541
Loa Loa (eye worm) glutamate receptor 0.0029 0.0032 0.0055
Onchocerca volvulus 0.0029 0.0032 0.008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0195 0.0337 0.0386
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0066 0.32
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.2049 0.3766 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0004 0.0123
Echinococcus granulosus g protein coupled receptor 0.0195 0.0337 0.0386
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0029 0.0032 0.008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0073 0.0112 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0028 0.0646
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0004 0.0123
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0005 0.0004
Echinococcus multilocularis glutamate receptor 2 0.0055 0.008 0.009
Schistosoma mansoni inositol monophosphatase 0.0038 0.0048 0.0112
Loa Loa (eye worm) TK/ROR protein kinase 0.0013 0.0002 0.0001
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0004 0.0175
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0093 0.015 0.0171
Trypanosoma brucei 2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like protein, putative 0.0017 0.0009 0.0014
Schistosoma mansoni hypothetical protein 0.0069 0.0105 0.025
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0195 0.0337 0.0812
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0015 0.0016
Toxoplasma gondii melibiase subfamily protein 0.0104 0.017 0.501
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0005 0.0104
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0004 0.0175
Brugia malayi Melatonin receptor type 1A 0.0195 0.0337 0.0337
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0015 0.0036
Trypanosoma brucei 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 0.0103 0.0168 0.0299
Schistosoma mansoni myosin xvIII 0.0195 0.0337 0.0812
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0066 0.0116
Echinococcus multilocularis sex peptide receptor 0.0195 0.0337 0.0386
Brugia malayi hypothetical protein 0.0073 0.0112 0.0111
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0195 0.0337 0.0812
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0015 0.0016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0195 0.0337 0.0812
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0015 0.0033
Brugia malayi Dopamine receptor 0.0195 0.0337 0.0337
Onchocerca volvulus 0.0031 0.0035 0.0088
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0018 0.0413
Brugia malayi follicle stimulating hormone receptor 0.0195 0.0337 0.0337
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0048 0.0084
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0009 0.0384
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0015 0.0016
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.0006 0.0009
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0044 0.1058
Echinococcus granulosus nuclear factor of activated T cells 5 0.0076 0.0118 0.0134
Brugia malayi Death domain containing protein 0.0015 0.0005 0.0004
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0195 0.0337 0.0812
Echinococcus granulosus Ankyrin 0.0015 0.0005 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0002 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0195 0.0337 0.0386
Echinococcus multilocularis survival motor neuron protein 1 0.0477 0.086 0.0988
Loa Loa (eye worm) glutamate receptor 1 0.0064 0.0096 0.017
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0015 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0066 0.0066
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0006 0.0005
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0009 0.0014
Echinococcus multilocularis biogenic amine (5HT) receptor 0.2248 0.4134 0.4756
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.0184 0.8868
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0046 0.008
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0015 0.0036
Echinococcus granulosus serotonin transporter 0.0195 0.0338 0.0387
Loa Loa (eye worm) hypothetical protein 0.0048 0.0066 0.0116
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0195 0.0337 0.0812
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0063 0.0112
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0195 0.0337 0.0812
Plasmodium vivax glutathione reductase, putative 0.0049 0.0068 0.1967
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0066 0.32
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.0076
Echinococcus multilocularis sodium and chloride dependent glycine 0.1002 0.1831 0.2105
Echinococcus granulosus fmrfamide receptor 0.0195 0.0337 0.0386
Schistosoma mansoni hypothetical protein 0.0015 0.0005 0.0008
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0073 0.0113 0.0269
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0195 0.0337 0.0812
Schistosoma mansoni glutamate receptor NMDA 0.0232 0.0406 0.0979
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0015 0.0033
Echinococcus granulosus tumor protein p63 0.0682 0.1239 0.1424
Trichomonas vaginalis 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative 0.0017 0.0009 0.019
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0066 0.32
Schistosoma mansoni cellular tumor antigen P53 0.01 0.0162 0.0389
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0195 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Onchocerca volvulus 0.0195 0.0338 0.0894
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0048 0.0053
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1002 0.1831 0.183
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0015 0.0015
Loa Loa (eye worm) neuropeptide F receptor 0.0195 0.0337 0.0602
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0029 0.0032 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0015 0.0016
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0015 0.0015
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0044 0.125
Loa Loa (eye worm) doublecortin family protein 0.002 0.0015 0.0025
Echinococcus granulosus glutamate receptor 2 0.0055 0.008 0.009
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0004 0.0004
Onchocerca volvulus 0.002 0.0015 0.0036
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0068 0.0076
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0066 0.3796
Schistosoma mansoni alpha-1 adrenergic receptor 0.0195 0.0337 0.0812
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0004 0.0004
Brugia malayi metabotropic glutamate receptor type 2 0.0029 0.0032 0.0031
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.2049 0.3766 0.6737
Schistosoma mansoni glutamate receptor NMDA 0.0378 0.0677 0.1634
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0041 0.095
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0015 0.0015
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0164 0.0163
Schistosoma mansoni amine GPCR 0.0195 0.0337 0.0812
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0009 0.0431
Loa Loa (eye worm) hypothetical protein 0.0048 0.0066 0.0116
Loa Loa (eye worm) hypothetical protein 0.0195 0.0338 0.0603
Loa Loa (eye worm) glutathione reductase 0.0049 0.0068 0.012
Echinococcus granulosus sex peptide receptor 0.0195 0.0337 0.0386
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0104 0.017 0.0194
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0058 0.0085 0.411
Echinococcus granulosus neuropeptide receptor 0.0195 0.0337 0.0386
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0195 0.0337 0.0386
Schistosoma mansoni hypothetical protein 0.002 0.0015 0.0033
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0048 0.0084
Brugia malayi ecdysteroid receptor 0.002 0.0015 0.0015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0164 0.0163
Loa Loa (eye worm) solute carrier family 6 member 4 0.0195 0.0338 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0006 0.0134
Loa Loa (eye worm) hypothetical protein 0.1551 0.2846 0.5091
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1637 0.3005 0.3456
Schistosoma mansoni biogenic amine (5HT) receptor 0.0195 0.0337 0.0812
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0068 0.3288
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0195 0.0337 0.0812
Loa Loa (eye worm) serotonin transporter b 0.0195 0.0338 0.0603
Brugia malayi nuclear hormone receptor 0.002 0.0015 0.0015
Echinococcus granulosus FTZ F1 alpha 0.002 0.0015 0.0016
Schistosoma mansoni lipoxygenase 0.0122 0.0203 0.0487
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.0204 0.049
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0037 0.004
Loa Loa (eye worm) RecQ helicase 0.0022 0.0018 0.0031
Onchocerca volvulus 0.0195 0.0337 0.0892
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0063 0.0112
Echinococcus granulosus rhodopsin orphan GPCR 0.0195 0.0337 0.0386
Onchocerca volvulus 0.0195 0.0337 0.0892
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0028 0.0646
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Echinococcus multilocularis neuropeptides capa receptor 0.0195 0.0337 0.0386
Toxoplasma gondii thioredoxin reductase 0.0049 0.0068 0.1967
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0204 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0015 0.0036
Brugia malayi glutathione reductase 0.0049 0.0068 0.0067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0195 0.0337 0.0812
Schistosoma mansoni hypothetical protein 0.0032 0.0037 0.0084
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0007
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0195 0.0337 0.0386
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Loa Loa (eye worm) glutamate receptor 2 0.0064 0.0096 0.017
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0038 0.0048 0.0053
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0195 0.0338 1
Onchocerca volvulus 0.0195 0.0337 0.0892
Echinococcus multilocularis neuropeptide FF receptor 2 0.0195 0.0337 0.0386
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0004 0.0123
Giardia lamblia 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 0.0103 0.0168 1
Plasmodium vivax hypothetical protein, conserved 0.0195 0.0338 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0195 0.0337 0.0386
Brugia malayi Pre-SET motif family protein 0.0215 0.0375 0.0374
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0195 0.0338 0.0814
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0004 0.0123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0195 0.0337 0.0812
Echinococcus granulosus orexin receptor type 2 0.0195 0.0337 0.0386
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0195 0.0338 0.0387
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0004 0.0003
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.017 0.0408
Schistosoma mansoni nuclear hormone receptor 0.002 0.0015 0.0033
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0204 1
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0048 0.0053
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0066 0.3081
Schistosoma mansoni netrin receptor unc5 0.0015 0.0005 0.0008
Trypanosoma brucei trypanothione reductase 0.0049 0.0068 0.012
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0204 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0001
Echinococcus multilocularis g protein coupled receptor 0.0195 0.0337 0.0386
Trypanosoma cruzi extracellular receptor, putative 0.0029 0.0032 0.0055
Echinococcus granulosus G protein coupled receptor 139 0.0195 0.0337 0.0386
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0015 0.0404
Echinococcus granulosus neuropeptide Y receptor 0.0195 0.0337 0.0386
Loa Loa (eye worm) G-protein coupled receptor 0.0195 0.0337 0.0602
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0058 0.0085 0.2299
Trypanosoma brucei C-8 sterol isomerase, putative 0.3035 0.5589 1
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0058 0.0085 0.4098
Entamoeba histolytica 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative 0.0103 0.0168 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0066 0.3202
Echinococcus granulosus metabotropic glutamate receptor 5 0.0029 0.0032 0.0035
Onchocerca volvulus 0.0073 0.0113 0.0296
Brugia malayi hypothetical protein 0.0195 0.0337 0.0337
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0009 0.0193
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.0076
Treponema pallidum sodium- and chloride- dependent transporter 0.0195 0.0338 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0195 0.0337 0.0812
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0063 0.0112
Echinococcus granulosus neuropeptide receptor 0.0195 0.0337 0.0386
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0046 0.008
Loa Loa (eye worm) hypothetical protein 0.0073 0.0113 0.02
Onchocerca volvulus 0.0097 0.0158 0.0414
Schistosoma mansoni neuropeptide receptor 0.0195 0.0337 0.0812
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0112 0.0267
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0009 0.0014
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0195 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0004 0.0123
Leishmania major extracellular receptor, putative 0.0029 0.0032 0.0055
Loa Loa (eye worm) G-protein coupled receptor 0.0195 0.0337 0.0602
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0066 0.3796
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Loa Loa (eye worm) RGC/RGC protein kinase 0.0029 0.0032 0.0055
Schistosoma mansoni lipoxygenase 0.0085 0.0135 0.0323
Brugia malayi Metabotropic glutamate receptor precursor. 0.0029 0.0032 0.0031
Leishmania major 2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like 0.0017 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.0032 0.0037 0.0063
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0004 0.0175
Onchocerca volvulus 0.0065 0.0098 0.0256
Echinococcus multilocularis g-protein coupled receptor 0.0195 0.0337 0.0386
Schistosoma mansoni neuropeptide F-like receptor 0.0195 0.0337 0.0812
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0041 0.1973
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0015 0.0016
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0195 0.0338 0.0814
Brugia malayi hypothetical protein 0.0195 0.0337 0.0337
Echinococcus multilocularis serotonin receptor 0.0195 0.0337 0.0386
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0041 0.183
Schistosoma mansoni neuropeptide f receptor 76f 0.0195 0.0337 0.0812
Schistosoma mansoni opsin-like receptor 0.0195 0.0337 0.0812
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0033 0.0035
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0195 0.0337 0.0812
Onchocerca volvulus 0.0195 0.0337 0.0892
Echinococcus granulosus tachykinin peptides receptor 99D 0.0195 0.0337 0.0386
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0104 0.017 0.0194
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0195 0.0337 0.0386
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Brugia malayi Protein kinase domain containing protein 0.0013 0.0002 0.0001
Schistosoma mansoni hypothetical protein 0.0032 0.0037 0.0084
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0004 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0004 0.0123
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0038 0.0048 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0051 0.117
Echinococcus granulosus 7TM GPCR rhodopsin 0.0195 0.0337 0.0386
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0044 0.125
Brugia malayi Serotonin receptor 0.0195 0.0337 0.0337
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0004 0.0004
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0112 0.0127
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0063 0.3631
Loa Loa (eye worm) hypothetical protein 0.0029 0.0032 0.0055
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.0204 0.049
Echinococcus multilocularis GPCR, family 2 0.0032 0.0037 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0006 0.0134
Schistosoma mansoni loxhd1 0.002 0.0015 0.0033
Echinococcus granulosus 7tm_1 domain containing protein 0.0195 0.0337 0.0386
Brugia malayi steroid hormone receptor 0.002 0.0015 0.0015
Brugia malayi Guanylyl cyclase protein 23 0.0029 0.0032 0.0031
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.001 0.002
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0195 0.0337 0.0386
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0009 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0195 0.0337 0.0812
Schistosoma mansoni biogenic amine receptor 0.0195 0.0337 0.0812
Echinococcus multilocularis rhodopsin orphan GPCR 0.0195 0.0337 0.0386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0041 0.095
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0014
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0066 0.32
Onchocerca volvulus 0.0245 0.043 0.1138
Leishmania major 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 0.0103 0.0168 0.0299
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0195 0.0338 0.0603
Echinococcus multilocularis sodium and chloride dependent glycine 0.1002 0.1831 0.2105
Schistosoma mansoni biogenic amine receptor 0.0195 0.0337 0.0812
Echinococcus multilocularis RUN 0.002 0.0015 0.0016
Echinococcus granulosus neuropeptide s receptor 0.0195 0.0337 0.0386
Echinococcus multilocularis glutamate receptor 2 0.0064 0.0096 0.0109
Brugia malayi neuropeptide F receptor 0.0195 0.0337 0.0337
Echinococcus granulosus receptor type guanylyl cyclase 0.0029 0.0032 0.0035
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0195 0.0337 0.0812
Schistosoma mansoni coup transcription factor 0.002 0.0015 0.0033
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0015 0.0015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0014
Brugia malayi Uncoordinated protein 44 0.0015 0.0005 0.0004
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0195 0.0337 0.0386
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0029 0.0032 0.0035
Loa Loa (eye worm) hypothetical protein 0.0029 0.0032 0.0055
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.0184 0.8887
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0015 0.0016
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0058 0.0085 0.2299
Trypanosoma cruzi 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative 0.0017 0.0009 0.0014
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.0006 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0063 0.1463
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0004 0.0069
Brugia malayi Receptor family ligand binding region containing protein 0.0029 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0015 0.0025
Brugia malayi hypothetical protein 0.0029 0.0032 0.0031
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0093 0.015 0.0171
Loa Loa (eye worm) hypothetical protein 0.0069 0.0106 0.0188
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0018 0.0413
Onchocerca volvulus 0.0195 0.0337 0.0892
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Onchocerca volvulus 0.0195 0.0337 0.0892
Schistosoma mansoni amine GPCR 0.0195 0.0337 0.0812
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0037 0.004
Schistosoma mansoni hypothetical protein 0.0032 0.0037 0.0084
Echinococcus granulosus neuropeptide Y receptor 0.0195 0.0337 0.0386
Schistosoma mansoni neuropeptide receptor 0.0195 0.0337 0.0812
Loa Loa (eye worm) inositol-1 0.0038 0.0048 0.0084
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0015 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0015 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0055 0.0128
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0015 0.0015
Entamoeba histolytica hypothetical protein 0.0073 0.0112 0.6577
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.004 0.1944
Plasmodium vivax amine transporter, putative 0.0195 0.0338 1
Onchocerca volvulus 0.0029 0.0032 0.008
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0195 0.0338 1
Echinococcus granulosus bloom syndrome protein 0.0022 0.0018 0.0019
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0015 0.0016
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0004 0.0175
Schistosoma mansoni histamine h1 receptor 0.0195 0.0337 0.0812
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0048 0.138
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0195 0.0338 0.0814
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0123 0.0204 0.9893
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0005 0.0004
Echinococcus multilocularis G protein coupled receptor 139 0.0195 0.0337 0.0386
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0038 0.0048 0.0053
Schistosoma mansoni vesicular acetylcholine transporter 0.2049 0.3766 0.9108
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0006 0.0011
Entamoeba histolytica hypothetical protein 0.0073 0.0112 0.6577
Schistosoma mansoni metabotropic glutamate receptor 0.0029 0.0032 0.0073
Schistosoma mansoni hypothetical protein 0.0038 0.0048 0.0111
Echinococcus multilocularis tumor protein p63 0.0682 0.1239 0.1424
Onchocerca volvulus 0.0195 0.0338 0.0894
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0035 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0006 0.0134
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0014
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0005 0.0009
Echinococcus multilocularis serotonin transporter 0.0195 0.0338 0.0387
Plasmodium falciparum thioredoxin reductase 0.0049 0.0068 0.1967
Echinococcus granulosus serotonin receptor 0.0195 0.0337 0.0386
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0063 0.0071
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0043 0.0996
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0015 0.0033
Schistosoma mansoni hypothetical protein 0.0032 0.0037 0.0084
Schistosoma mansoni thyroid hormone receptor 0.002 0.0015 0.0033
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0009 0.0014
Schistosoma mansoni adenoreceptor 0.0195 0.0337 0.0812
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0004 0.0004
Schistosoma mansoni sodium/chloride dependent transporter 0.1002 0.1831 0.4426
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0004 0.0175
Loa Loa (eye worm) hypothetical protein 0.0195 0.0338 0.0603
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0195 0.0337 0.0337
Brugia malayi Inositol-1 0.0038 0.0048 0.0048
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.1002 0.1831 0.3274
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0037 0.004
Brugia malayi putative neuropeptide receptor 0.0195 0.0337 0.0337
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0063 0.0112
Loa Loa (eye worm) hypothetical protein 0.0195 0.0338 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0046 0.1054
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0066 0.0066
Brugia malayi larval opioid receptor 0.0195 0.0337 0.0337
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0009 0.0215
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.0184 0.8887
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0195 0.0337 0.0386
Echinococcus multilocularis nmda type glutamate receptor 0.0381 0.0682 0.0783
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0006 0.0009
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0093 0.015 0.0171
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0005 0.0009
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0195 0.0337 0.0337
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0004 0.0123
Onchocerca volvulus Neuropeptide F receptor homolog 0.0195 0.0337 0.0892
Trichomonas vaginalis set domain proteins, putative 0.0245 0.043 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0066 0.0116
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.0076
Plasmodium falciparum thioredoxin reductase 0.0017 0.0009 0.0215
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0037 0.0036
Brugia malayi ORL1-like opioid receptor 0.0195 0.0337 0.0337
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0068 0.012
Schistosoma mansoni sodium/chloride dependent transporter 0.0195 0.0338 0.0814
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0015 0.0015
Trypanosoma cruzi C-8 sterol isomerase, putative 0.3035 0.5589 1
Echinococcus multilocularis orexin receptor type 2 0.0195 0.0337 0.0386
Entamoeba histolytica hypothetical protein 0.0029 0.0032 0.1707
Brugia malayi hypothetical protein 0.0195 0.0337 0.0337
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0009 0.0014
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0195 0.0338 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0029 0.0658
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0013 0.0349
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0195 0.0338 0.0387
Brugia malayi hypothetical protein 0.0195 0.0337 0.0337
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0004 0.0004
Echinococcus multilocularis neuropeptide receptor 0.0195 0.0337 0.0386
Brugia malayi hypothetical protein 0.0195 0.0337 0.0337
Echinococcus multilocularis fmrfamide receptor 0.0195 0.0337 0.0386
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0029 0.0032 0.0035
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0004 0.0002
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0015 0.0016
Brugia malayi hypothetical protein 0.0195 0.0337 0.0337
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.004 0.1944
Brugia malayi hypothetical protein 0.0195 0.0337 0.0337
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0048 0.2703
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0004 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0046 0.1054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0029 0.0658
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0044 0.2099
Echinococcus granulosus rhodopsin orphan GPCR 0.0195 0.0337 0.0386
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0029 0.0032 0.0035
Brugia malayi hypothetical protein 0.002 0.0015 0.0015
Echinococcus granulosus atrial natriuretic peptide receptor 0.0029 0.0032 0.0035
Echinococcus granulosus g protein coupled receptor 0.0195 0.0337 0.0386
Brugia malayi Cytochrome P450 family protein 0.0013 0.0001 0.0001
Echinococcus multilocularis vesicular acetylcholine transporter 0.2049 0.3766 0.4332
Schistosoma mansoni protein kinase 0.0029 0.0032 0.0073
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0009 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0046 0.1054
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Loa Loa (eye worm) hypothetical protein 0.0195 0.0338 0.0603
Schistosoma mansoni opsin-like receptor 0.0195 0.0337 0.0812
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0066 0.32
Schistosoma mansoni growth hormone secretagogue receptor 0.0195 0.0337 0.0812
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0195 0.0338 0.0814
Echinococcus multilocularis conserved hypothetical protein 0.1231 0.2254 0.2592
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0048 0.0084
Echinococcus multilocularis dro:myosuppressin receptor 0.0195 0.0337 0.0386
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0044 0.2119
Brugia malayi Thioredoxin reductase 0.0049 0.0068 0.0067
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0066 0.0116
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.0203 0.0231
Toxoplasma gondii aldehyde dehydrogenase 0.0123 0.0204 0.602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0035 0.0805
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0066 0.32
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0048 0.0084
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0195 0.0337 0.0812
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0195 0.0338 0.0814
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0195 0.0338 0.0338
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0015 0.0033
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0004 0.0123
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0076 0.0118 0.0134
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0029 0.0032 0.0055
Onchocerca volvulus 0.0195 0.0337 0.0892
Echinococcus granulosus tyrosine kinase 0.0029 0.0032 0.0035
Schistosoma mansoni glutamate receptor kainate 0.0064 0.0096 0.0228
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Echinococcus granulosus glutamate NMDA receptor subunit 0.0232 0.0406 0.0466
Brugia malayi Dopamine receptor protein 1 0.0195 0.0337 0.0337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0046 0.1054
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0015 0.0016
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0043 0.0996
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0055 0.0128
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0195 0.0338 0.0814
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0015 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0015 0.0015
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0063 0.0149
Echinococcus granulosus glutamate receptor NMDA 0.0285 0.0505 0.0579
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0004 0.0004
Schistosoma mansoni glutamate receptor AMPA 0.0064 0.0096 0.0228
Echinococcus multilocularis serotonin receptor 0.0195 0.0337 0.0386
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.4712 0.8691 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0069 0.0106 0.2458
Schistosoma mansoni hypothetical protein 0.0195 0.0337 0.0812
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0018 0.0031
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0195 0.0337 0.0337
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0195 0.0337 0.0386
Onchocerca volvulus 0.0014 0.0004 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0014
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0035 0.0038
Schistosoma mansoni hypothetical protein 0.0195 0.0337 0.0812
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0006 0.0009
Brugia malayi hypothetical protein 0.0195 0.0337 0.0337
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0104 0.017 0.0194
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0038 0.0048 0.0053
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0195 0.0337 0.0812
Schistosoma mansoni tyrosine kinase 0.0029 0.0032 0.0073
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0068 0.1967
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0195 0.0337 0.0812
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0008
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0041 0.1181
Onchocerca volvulus 0.01 0.0162 0.0427
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0068 0.012
Loa Loa (eye worm) hypothetical protein 0.01 0.0162 0.0288
Loa Loa (eye worm) hypothetical protein 0.0073 0.0113 0.02
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0004 0.0123
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0004 0.0123
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0038 0.0048 0.0053
Echinococcus multilocularis neuropeptide receptor A26 0.0195 0.0337 0.0386
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0037 0.004
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0009 0.0215
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0195 0.0337 0.0812
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0063 0.0112
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0195 0.0337 0.0386
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0063 0.0063
Entamoeba histolytica 2,3-bisphosphoglycerate-independentphosphoglycerate mutase, putative 0.0057 0.0083 0.4799
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0195 0.0337 0.0386
Toxoplasma gondii Alpha-galactosidase 0.0015 0.0005 0.0096
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0195 0.0337 0.0386
Echinococcus granulosus rhodopsin orphan GPCR 0.0195 0.0337 0.0386
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0195 0.0337 0.0386
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0058 0.0085 0.2299
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0164 0.0291
Onchocerca volvulus 0.0195 0.0338 0.0894
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0004 0.0058
Onchocerca volvulus 0.0048 0.0066 0.0171
Brugia malayi hypothetical protein 0.0195 0.0337 0.0337
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0029 0.0032 0.0031
Schistosoma mansoni inositol monophosphatase 0.0038 0.0048 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Trypanosoma cruzi 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative 0.0103 0.0168 0.0299
Echinococcus multilocularis glutamate receptor 2 0.0093 0.015 0.0171
Brugia malayi Trypsin family protein 0.0073 0.0113 0.0112
Echinococcus granulosus RUN 0.002 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.0076
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0195 0.0337 0.0892
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.0006 0.0009
Mycobacterium tuberculosis Probable reductase 0.0111 0.0184 0.8887
Onchocerca volvulus 0.0014 0.0004 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0024 0.0543
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.0207 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0009 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0004 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.004 0.1944
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.0006 0.0009
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0195 0.0337 0.0386
Onchocerca volvulus 0.0195 0.0337 0.0892
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0123 0.0204 0.0364
Echinococcus granulosus rhodopsin orphan GPCR 0.0195 0.0337 0.0386
Brugia malayi neuropeptide F receptor 0.0195 0.0337 0.0337
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0015 0.0016
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0004 0.0003
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0195 0.0338 0.0387
Loa Loa (eye worm) hypothetical protein 0.0195 0.0338 0.0603
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0015 0.0404
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0063 0.0112
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0195 0.0337 0.0602
Loa Loa (eye worm) hypothetical protein 0.0029 0.0032 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0015 0.0015
Onchocerca volvulus 0.0195 0.0337 0.0892
Echinococcus granulosus glutamate receptor 2 0.0093 0.015 0.0171
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0037 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0024 0.0541
Echinococcus multilocularis g protein coupled receptor 0.0195 0.0337 0.0386
Schistosoma mansoni survival motor neuron protein 0.0097 0.0158 0.0378
Echinococcus multilocularis neuropeptide receptor 0.0195 0.0337 0.0386
Echinococcus granulosus nmda type glutamate receptor 0.0381 0.0682 0.0783
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0066 0.32
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0195 0.0338 0.0814
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.0203 0.0231
Brugia malayi RE15519p 0.0195 0.0337 0.0337
Onchocerca volvulus 0.0195 0.0337 0.0892
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0093 0.015 0.0171
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0048 0.1107
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0004 0.0003
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0123 0.0204 0.0233
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0029 0.0032 0.0055
Echinococcus multilocularis tyrosine kinase 0.0029 0.0032 0.0035
Leishmania major C-8 sterol isomerase-like protein 0.3035 0.5589 1
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Toxoplasma gondii hypothetical protein 0.0195 0.0338 1
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0066 0.3202
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0009 0.0014
Schistosoma mansoni glutamate receptor AMPA 0.0064 0.0096 0.0228
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0005 0.0007
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0195 0.0338 0.0814
Schistosoma mansoni rab6-interacting 0.002 0.0015 0.0033
Plasmodium falciparum transporter, putative 0.0195 0.0338 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0029 0.0032 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0024 0.0541
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0005 0.0004
Echinococcus granulosus neuropeptide FF receptor 2 0.0195 0.0337 0.0386
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0015 0.0016
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0195 0.0338 0.0387
Loa Loa (eye worm) independent phosphoglycerate mutase isoform 2 0.0103 0.0168 0.0299
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0195 0.0338 0.0338
Echinococcus granulosus sodium and chloride dependent glycine 0.1002 0.1831 0.2105
Plasmodium falciparum glutathione reductase 0.0017 0.0009 0.0215
Schistosoma mansoni neuropeptide F-like receptor 0.0195 0.0337 0.0812
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0063 0.0112
Trypanosoma cruzi 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative 0.0017 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Echinococcus granulosus vesicular acetylcholine transporter 0.2049 0.3766 0.4332
Schistosoma mansoni neuropeptide receptor 0.0195 0.0337 0.0812
Echinococcus granulosus biogenic amine 5HT receptor 0.0195 0.0337 0.0386
Echinococcus granulosus somatostatin receptor 0.0195 0.0337 0.0386
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0004 0.0123
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0004 0.0004
Onchocerca volvulus 0.0195 0.0337 0.0892
Schistosoma mansoni tyrosine kinase 0.0029 0.0032 0.0073
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0004 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0024 0.0543
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0014
Loa Loa (eye worm) TYRA-2 protein 0.0195 0.0337 0.0602
Echinococcus granulosus dro:myosuppressin receptor 0.0195 0.0337 0.0386
Brugia malayi G-protein coupled receptor 0.0195 0.0337 0.0337
Leishmania major hypothetical protein, conserved 0.0013 0.0002 0.0001
Schistosoma mansoni rab6-interacting 0.002 0.0015 0.0033
Entamoeba histolytica hypothetical protein 0.0073 0.0112 0.6577
Loa Loa (eye worm) hypothetical protein 0.0101 0.0164 0.0291
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0006 0.0006
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.017 0.0408
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0005 0.0094
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0048 0.0053
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0105 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0015 0.0015
Wolbachia endosymbiont of Brugia malayi phosphoglyceromutase 0.0103 0.0168 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0006 0.0009
Echinococcus multilocularis nmda type glutamate receptor 0.0314 0.0559 0.0641
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0195 0.0337 0.0812
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0035 0.008
Echinococcus granulosus nmda type glutamate receptor 0.0314 0.0559 0.0641
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0384
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0006 0.0005
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0004 0.0123
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0048 0.2314
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0004 0.0004
Brugia malayi Kringle domain containing protein 0.0013 0.0002 0.0001
Echinococcus granulosus peptide allatostatin:somatostatin 0.0195 0.0337 0.0386
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0195 0.0337 0.0386
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0195 0.0337 0.0812
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0004 0.0069
Schistosoma mansoni metabotropic glutamate receptor 0.0029 0.0032 0.0073
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Onchocerca volvulus 0.0195 0.0337 0.0892
Onchocerca volvulus 0.0014 0.0004 0.0005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0112 0.0127
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Schistosoma mansoni hypothetical protein 0.0195 0.0337 0.0812
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0068 0.0076
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0093 0.015 0.0171
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.0076
Schistosoma mansoni neuropeptide receptor 0.0195 0.0337 0.0812
Loa Loa (eye worm) melatonin receptor type 1A 0.0195 0.0337 0.0602
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0015 0.0015
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0048 0.1107
Onchocerca volvulus 0.0195 0.0337 0.0892
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0195 0.0338 0.0387
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0048 0.0084
Brugia malayi Glutamate receptor 1 precursor 0.0064 0.0096 0.0095
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0195 0.0338 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0015 0.0016
Brugia malayi Cytochrome P450 family protein 0.0013 0.0001 0.0001
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0066 0.0116
Schistosoma mansoni ATP-binding cassette transporter 0.0064 0.0096 0.0228
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0015 0.0033
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0004 0.0123
Onchocerca volvulus 0.0195 0.0337 0.0892
Echinococcus multilocularis NMDA receptor 0.0038 0.0048 0.0053
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0093 0.015 0.0171
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0195 0.0337 0.0386
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0195 0.0337 0.0386
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0195 0.0338 0.0387
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Onchocerca volvulus 0.0195 0.0337 0.0892
Echinococcus multilocularis Ankyrin 0.0015 0.0005 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0015 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0015 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0006 0.0134
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.0184 0.8887
Echinococcus granulosus neuropeptide receptor A26 0.0195 0.0337 0.0386
Plasmodium falciparum glutathione reductase 0.0049 0.0068 0.1967
Brugia malayi putative neuropeptide receptor NPR1 0.0195 0.0337 0.0337
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.0207 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0195 0.0337 0.0602
Loa Loa (eye worm) hypothetical protein 0.0029 0.0032 0.0055
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0004 0.0058
Echinococcus granulosus g protein coupled receptor 0.0195 0.0337 0.0386
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0004 0.0123
Loa Loa (eye worm) RGC/RGC protein kinase 0.0029 0.0032 0.0055
Giardia lamblia GTOR 0.0046 0.0063 0.342
Echinococcus multilocularis neuropeptide Y receptor 0.0195 0.0337 0.0386
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0195 0.0337 0.0602
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0004 0.0175
Brugia malayi GnHR receptor homolog 0.0195 0.0337 0.0337
Echinococcus multilocularis rhodopsin orphan GPCR 0.0195 0.0337 0.0386
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0195 0.0337 0.0602
Loa Loa (eye worm) hypothetical protein 0.1002 0.1831 0.3274
Loa Loa (eye worm) hypothetical protein 0.0069 0.0105 0.0186
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0067
Loa Loa (eye worm) hypothetical protein 0.0029 0.0032 0.0055
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0009 0.0215
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0015 0.0015
Brugia malayi Pre-SET motif family protein 0.0031 0.0035 0.0034
Echinococcus multilocularis glutamate receptor NMDA 0.0285 0.0505 0.0579
Echinococcus granulosus sodium and chloride dependent glycine 0.1002 0.1831 0.2105
Toxoplasma gondii hypothetical protein 0.0195 0.0338 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0015 0.0033
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0195 0.0337 0.0337
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0004 0.0175
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0015 0.0025
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0232 0.0406 0.0466
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0013 0.0022
Brugia malayi Protein kinase domain containing protein 0.0015 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0195 0.0338 0.0603
Entamoeba histolytica hypothetical protein 0.0073 0.0112 0.6577
Brugia malayi ERG2 and Sigma1 receptor like protein 0.3035 0.5589 0.5588
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0014
Brugia malayi AKH receptor 0.0195 0.0337 0.0337
Brugia malayi Tachykinin-like peptides receptor 99D 0.0195 0.0337 0.0337
Schistosoma mansoni amine GPCR 0.0195 0.0337 0.0812
Echinococcus granulosus tm gpcr rhodopsin 0.0195 0.0337 0.0386
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0009 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0029 0.0658
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0008
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0063 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0041 0.095
Brugia malayi hypothetical protein 0.0195 0.0337 0.0337
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0004 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0035 0.008
Brugia malayi nuclear receptor NHR-88 0.002 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0029 0.0032 0.0055
Echinococcus granulosus death domain containing protein 0.0015 0.0005 0.0004
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.0375 0.0669
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0048 0.2461
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0004 0.0058
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0015 0.0005 0.0008
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Echinococcus granulosus hypothetical protein 0.1425 0.2613 0.3006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0015 0.0033
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0014
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0066 0.3081
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0195 0.0337 0.0812
Brugia malayi G protein-coupled receptor F59B2.13 0.0195 0.0337 0.0337
Schistosoma mansoni glutamate receptor kainate 0.0064 0.0096 0.0228
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Echinococcus multilocularis neuropeptide Y receptor 0.0195 0.0337 0.0386
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0195 0.0338 0.0814
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Schistosoma mansoni glutamate receptor kainate 0.0064 0.0096 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0195 0.0337 0.0386
Brugia malayi Glutamate receptor 2 precursor 0.0064 0.0096 0.0095
Echinococcus granulosus g-protein coupled receptor 0.0195 0.0337 0.0386
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0004 0.0175
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0195 0.0337 0.0602
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0035 0.0979
Brugia malayi G-protein coupled receptor 0.0195 0.0337 0.0337
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0009 0.0215
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0009 0.0384
Brugia malayi hypothetical protein 0.002 0.0015 0.0015
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0009 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0041 0.095
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.017 0.0408
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0195 0.0337 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0041 0.095

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 2 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 3.43 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 4.05 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 11.99 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 13 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 94 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 1.39 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -4 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 2 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 13 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 94 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.03 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.93235 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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