Detailed information for compound 606428

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 309.405 | Formula: C19H23N3O
  • H donors: 0 H acceptors: 0 LogP: 3.09 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1ccc(cc1)N=Cc1ccc(cc1)N1CCOCC1)C
  • InChi: 1S/C19H23N3O/c1-21(2)18-9-5-17(6-10-18)20-15-16-3-7-19(8-4-16)22-11-13-23-14-12-22/h3-10,15H,11-14H2,1-2H3/b20-15+
  • InChiKey: MOQNWJSCPYWTQR-HMMYKYKNSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0079 0.099 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0218 0.169
Echinococcus granulosus c src tyrosine kinase 0.0027 0.0194 0.0194
Entamoeba histolytica hypothetical protein 0.0037 0.0352 0.2798
Loa Loa (eye worm) PHD-finger family protein 0.0044 0.0459 0.2205
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0079 0.099 0.8098
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0086 0.0592
Onchocerca volvulus 0.0015 0.0021 0.0079
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.1981 0.8955
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0218 0.0202
Brugia malayi protein-tyrosine kinase 0.0106 0.1396 0.631
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0692 0.0676
Entamoeba histolytica type A flavoprotein, putative 0.0079 0.099 0.8098
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0118 0.1569 0.1569
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.0651 0.1156
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0079 0.099 1
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0399 0.1916
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.1265 0.1265
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.0651 0.6358
Schistosoma mansoni intermediate filament proteins 0.0026 0.0192 0.0176
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0079 0.099 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0086 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0195 0.0825
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0079 0.099 1
Leishmania major protein kinase, putative 0.0039 0.0383 0.3468
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0152 0.0152
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0086 0.0273
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0061 0.0044
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0692 0.6791
Echinococcus multilocularis tyrosine kinase 0.0015 0.0021 0.0021
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0077 0.0952 0.0952
Echinococcus granulosus tyrosine kinase 0.0015 0.0021 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Schistosoma mansoni zinc finger protein 0.0042 0.0425 0.0409
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0458 0.4278
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0329 0.158
Onchocerca volvulus 0.0018 0.0061 0.0381
Schistosoma mansoni tyrosine kinase 0.0027 0.0194 0.0178
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0352 0.0352
Brugia malayi Sugar transporter family protein 0.0018 0.0061 0.0266
Loa Loa (eye worm) TK protein kinase 0.0095 0.1219 0.5873
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0329 0.2891
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0592 0.0681
Schistosoma mansoni lamin 0.0026 0.0192 0.0176
Trichomonas vaginalis A-type flavoprotein 0.0079 0.099 0.5688
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.0651 0.0651
Echinococcus granulosus zinc phosphodiesterase 0.0079 0.099 0.099
Entamoeba histolytica alkyl sulfatase, putative 0.0079 0.099 0.8098
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0383 0.0383
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0916 0.9209
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0106 0.1396 0.1396
Trypanosoma cruzi ISWI complex protein 0.0033 0.0287 0.2433
Brugia malayi SRC-1 0.0118 0.1569 0.7094
Schistosoma mansoni bromodomain containing protein 0.0135 0.1834 0.182
Onchocerca volvulus 0.0018 0.0061 0.0381
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0039 0.0383 0.0413
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.0651 0.6358
Echinococcus multilocularis solute carrier family 22 0.0018 0.0061 0.0061
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0027 0.0195 0.145
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0284
Echinococcus granulosus tyrosine protein kinase Src42A 0.0118 0.1569 0.1569
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0079 0.099 0.5688
Echinococcus multilocularis peregrin 0.0035 0.0319 0.0319
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0916 0.9209
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0651 0.3616
Echinococcus granulosus tyrosine protein kinase Fyn 0.0118 0.1569 0.1569
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0021 0.0092
Onchocerca volvulus 0.0026 0.0192 0.1378
Schistosoma mansoni adapter molecule crk 0.0023 0.0144 0.0128
Schistosoma mansoni sugar transporter 0.0018 0.0061 0.0044
Mycobacterium ulcerans hydrolase 0.0079 0.099 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0218 0.0202
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.0651 0.3135
Trypanosoma cruzi hexose transporter 0.0039 0.0383 0.3468
Schistosoma mansoni zinc phosphodiesterase 0.0079 0.099 0.0975
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0021 0.0092
Schistosoma mansoni hypothetical protein 0.0033 0.0287 0.0271
Echinococcus granulosus zinc finger protein 0.0042 0.0425 0.0425
Toxoplasma gondii FATC domain-containing protein 0.0027 0.0195 0.0264
Trichomonas vaginalis beta lactamase domain, putative 0.0079 0.099 0.5688
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Loa Loa (eye worm) sugar transporter 0.0126 0.1694 0.8168
Echinococcus granulosus inositol monophosphatase 1 0.0075 0.0916 0.0916
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0692 0.6791
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0383 0.3468
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0079 0.099 1
Plasmodium falciparum hexose transporter 0.0126 0.1694 0.2092
Echinococcus multilocularis histone acetyltransferase MYST2 0.0116 0.1544 0.1544
Loa Loa (eye worm) hypothetical protein 0.0079 0.099 0.4768
Plasmodium falciparum calcium-dependent protein kinase 1 0.0039 0.0383 0.0413
Echinococcus granulosus pyruvate kinase 0.0036 0.0329 0.0329
Mycobacterium ulcerans hypothetical protein 0.0079 0.099 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0075 0.0916 0.7487
Plasmodium vivax hexose transporter 0.0126 0.1694 0.2092
Echinococcus granulosus tyrosine protein kinase Src42A 0.0103 0.1346 0.1346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0383 0.0383
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1981 0.1967
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0039 0.0383 0.0383
Loa Loa (eye worm) MBCTL1 0.0116 0.1544 0.7445
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0061 0.0266
Loa Loa (eye worm) mbt repeat family protein 0.0102 0.1331 0.6417
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0284
Onchocerca volvulus 0.0018 0.0061 0.0381
Trypanosoma brucei glucose transporter 1E 0.0039 0.0383 0.3468
Echinococcus granulosus polycomb protein SCMH1 0.0102 0.1331 0.1331
Brugia malayi hypothetical protein 0.0015 0.0021 0.0086
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0419 0.0419
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0329 0.2891
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0079 0.099 0.099
Echinococcus granulosus peregrin 0.0035 0.0319 0.0319
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1694 0.1694
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0118 0.1569 0.1569
Schistosoma mansoni pyruvate kinase 0.0018 0.0068 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0692 0.6791
Brugia malayi Tyrosine-protein kinase abl-1 0.0027 0.0194 0.0869
Echinococcus granulosus tyrosine protein kinase shark 0.0015 0.0021 0.0021
Echinococcus granulosus tyrosine protein kinase Lyn 0.0121 0.1613 0.1613
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0402 0.5854 0.5854
Schistosoma mansoni glucose transporter 0.0018 0.0061 0.0044
Onchocerca volvulus 0.0018 0.0061 0.0381
Schistosoma mansoni protein kinase 0.0039 0.0383 0.0367
Schistosoma mansoni protein kinase 0.0039 0.0383 0.0367
Echinococcus multilocularis serine protein kinase ATM 0.0027 0.0195 0.0195
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0399 0.0383
Mycobacterium ulcerans hypothetical protein 0.0079 0.099 1
Entamoeba histolytica alkyl sulfatase, putative 0.0079 0.099 0.8098
Schistosoma mansoni tyrosine kinase 0.0118 0.1569 0.1555
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0383 0.1972
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.052 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.0458 0.0509
Trichomonas vaginalis apoptosis inducing factor, putative 0.0079 0.099 0.5688
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0061 0.0284
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.0651 0.6358
Loa Loa (eye worm) hypothetical protein 0.0036 0.0329 0.158
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0798 0.7943
Brugia malayi hypothetical protein 0.0079 0.099 0.447
Schistosoma mansoni myelin transcription factor 1 myt1 0.0116 0.1544 0.153
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0916 0.5238
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0218 0.169
Onchocerca volvulus 0.0079 0.099 0.7413
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0023 0.0144 0.0687
Brugia malayi SH2 domain containing protein 0.0015 0.0021 0.0086
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0243 0.0243
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0192 0.0862
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0339 0.0339
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0079 0.099 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0337 0.0337
Echinococcus multilocularis pyruvate kinase 0.0036 0.0329 0.0329
Chlamydia trachomatis pyruvate kinase 0.0036 0.0329 0.1445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Echinococcus granulosus histone acetyltransferase MYST2 0.0116 0.1544 0.1544
Trichomonas vaginalis inositol monophosphatase, putative 0.0075 0.0916 0.5238
Mycobacterium ulcerans hypothetical protein 0.0079 0.099 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0092
Echinococcus granulosus serine protein kinase ATM 0.0027 0.0195 0.0195
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0116 0.1544 0.1544
Echinococcus multilocularis lamin 0.0026 0.0192 0.0192
Trypanosoma cruzi glyoxalase II 0.0079 0.099 1
Schistosoma mansoni glucose transport protein 0.0126 0.1694 0.168
Mycobacterium tuberculosis Conserved hypothetical protein 0.0079 0.099 1
Trypanosoma brucei protein kinase, putative 0.0057 0.0651 0.6358
Schistosoma mansoni protein kinase 0.0039 0.0383 0.0367
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0021 0.0092
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0651 0.3616
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0118 0.1569 0.1569
Schistosoma mansoni microtubule-associated protein tau 0.0678 1 1
Plasmodium falciparum protein kinase 7 0.0357 0.517 0.6546
Onchocerca volvulus 0.0015 0.0021 0.0079
Echinococcus granulosus tyrosine protein kinase Fyn 0.0118 0.1569 0.1569
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.123
Echinococcus granulosus tyrosine protein kinase Src64B 0.0118 0.1569 0.1569
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0383 0.0383
Leishmania major hypothetical protein, conserved 0.0079 0.099 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0118 0.1569 0.1569
Loa Loa (eye worm) hypothetical protein 0.0091 0.1168 0.5631
Entamoeba histolytica hypothetical protein 0.0028 0.0218 0.1685
Schistosoma mansoni tyrosine kinase 0.0015 0.0021 0.0004
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0086 0.007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0284
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0284
Mycobacterium ulcerans glyoxalase II, GloB 0.0079 0.099 1
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0068 0.001
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0023 0.0144 0.0128
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0218 0.0201
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0383 0.1973
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0329 0.1644
Trichomonas vaginalis beta lactamase domain, putative 0.0079 0.099 0.5688
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0329 0.2414
Onchocerca volvulus 0.0026 0.0192 0.1378
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0343 0.0327
Echinococcus multilocularis growth factor receptor bound protein 2 0.0023 0.0144 0.0144
Trypanosoma cruzi glyoxalase II 0.0079 0.099 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0364 0.0348
Loa Loa (eye worm) hypothetical protein 0.0051 0.0563 0.2711
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0079 0.099 0.099
Echinococcus multilocularis SAM and MBT domain containing protein 0.0102 0.1331 0.1331
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0284
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0061 0.0266
Plasmodium falciparum calcium-dependent protein kinase 3 0.0039 0.0383 0.0413
Trypanosoma cruzi glyoxalase II 0.0079 0.099 1
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0079 0.099 0.099
Echinococcus granulosus pyruvate kinase 0.0018 0.0068 0.0068
Trypanosoma brucei glucose transporter, putative 0.0039 0.0383 0.3468
Leishmania major glucose transporter, lmgt2 0.0039 0.0383 0.3468
Brugia malayi hypothetical protein 0.0034 0.0309 0.1391
Schistosoma mansoni sugar transporter 0.0018 0.0061 0.0044
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0592 0.5723
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0118 0.1569 0.1569
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0118 0.1569 0.1569
Brugia malayi Variant SH3 domain containing protein 0.0023 0.0144 0.0644
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0592 0.5723
Echinococcus granulosus tyrosine protein kinase ABL1 0.0015 0.0021 0.0021
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1694 0.1694
Mycobacterium tuberculosis Possible hydrolase 0.0079 0.099 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0106 0.1396 0.1396
Schistosoma mansoni pyruvate kinase 0.0036 0.0329 0.0313
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.0798 0.7714
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0592 0.5723
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0126 0.1694 0.1694
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0086 0.0273
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0102 0.1331 1
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0079 0.099 1
Brugia malayi Bromodomain containing protein 0.0082 0.1028 0.4645
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0103 0.1346 0.1346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0343 0.0327
Echinococcus multilocularis solute carrier family 22 0.0018 0.0061 0.0061
Schistosoma mansoni sugar transporter 0.0018 0.0061 0.0044
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0086 0.0406
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0195 0.145
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0086 0.0086
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0399 0.0383
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0021 0.0092
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0165 0.0641
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.099 0.5688
Schistosoma mansoni hypothetical protein 0.0044 0.0459 0.0443
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0458 0.4278
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0086 0.0381
Echinococcus granulosus tyrosine kinase 0.0106 0.1396 0.1396
Schistosoma mansoni sex comb on midleg homolog 0.0102 0.1331 0.1317
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0118 0.1569 0.1569
Trypanosoma brucei glucose transporter, putative 0.0039 0.0383 0.3468
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0692 0.6791
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0343 0.0343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0039 0.0383 0.0631
Schistosoma mansoni zinc finger protein 0.0033 0.0287 0.0271
Brugia malayi Protein kinase domain containing protein 0.0015 0.0021 0.0086
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0075 0.0916 0.9209
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0402 0.5854 0.5854
Schistosoma mansoni lamin 0.0026 0.0192 0.0176
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0343 0.0343
Entamoeba histolytica protein kinase, putative 0.0039 0.0383 0.3057
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0039 0.0383 0.0631
Treponema pallidum ribonuclease Z 0.0079 0.099 0.5
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0087 0.0279
Trypanosoma brucei glyoxalase II 0.0079 0.099 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0086 0.0273
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0038 0.0364 0.0364
Onchocerca volvulus 0.0018 0.0061 0.0381
Brugia malayi PHD-finger family protein 0.003 0.0243 0.109
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0218 0.0201
Echinococcus granulosus tyrosine protein kinase HCK 0.0095 0.1219 0.1219
Brugia malayi Variant SH3 domain containing protein 0.0023 0.0144 0.0644
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0284
Trypanosoma brucei glucose transporter, putative 0.0039 0.0383 0.3468
Plasmodium falciparum mitogen-activated protein kinase 2 0.0204 0.2872 0.3601
Mycobacterium tuberculosis Conserved protein 0.0079 0.099 1
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.0651 0.0651
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.0015 0.0021 0.0086
Onchocerca volvulus Putative transporter 0.0018 0.0061 0.0381
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0243 0.0243
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0016 0.0027 0.0124
Schistosoma mansoni tyrosine kinase 0.0118 0.1569 0.1555
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.0363 0.1743
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0218 0.0307
Giardia lamblia Pyruvate kinase 0.0018 0.0068 0.0084
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0916 0.5238
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0079 0.099 0.1818
Mycobacterium leprae Beta-lactamase-like protein 0.0079 0.099 1
Schistosoma mansoni glucose transport protein 0.0126 0.1694 0.168
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0154 0.1002
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0642 0.0642
Brugia malayi mbt repeat family protein 0.0102 0.1331 0.6017
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0038 0.0364 0.1855
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0086 0.0406
Echinococcus granulosus lamin 0.0026 0.0192 0.0192
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0079 0.099 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0592 0.0681
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0192 0.0919
Echinococcus multilocularis tyrosine protein kinase shark 0.0015 0.0021 0.0021
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0079 0.099 0.119
Toxoplasma gondii facilitative glucose transporter GT1 0.0126 0.1694 0.3196
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0218 0.0765
Trypanosoma brucei glucose transporter, putative 0.0039 0.0383 0.3468
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0039 0.0383 0.0413
Onchocerca volvulus 0.0079 0.099 0.7413
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0061 0.0061
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0962 0.0947
Onchocerca volvulus 0.0018 0.0061 0.0381
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0243 0.0356
Onchocerca volvulus 0.0018 0.0061 0.0381
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0218 0.169
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0383 0.1973
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0079 0.099 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1981 0.1967
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0642 0.6257
Echinococcus multilocularis tyrosine protein kinase Blk 0.0106 0.1396 0.1396
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1694 0.1694
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0383 0.0383
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0086 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Echinococcus granulosus NCK adaptor protein 0.0023 0.0144 0.0144
Echinococcus granulosus solute carrier family 22 0.0018 0.0061 0.0061
Echinococcus granulosus solute carrier family 22 0.0018 0.0061 0.0061
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase Srms 0.0015 0.0021 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.099 0.5688
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.0651 0.6358
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0061 0.0284
Plasmodium vivax calcium-dependent protein kinase, putative 0.0039 0.0383 0.0413
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0167 0.1266
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0399 0.0399
Brugia malayi Protein kinase domain containing protein 0.0015 0.0021 0.0086
Onchocerca volvulus 0.0018 0.0061 0.0381
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0068 0.001
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0027 0.0195 0.0179
Onchocerca volvulus 0.0015 0.0021 0.0079
Brugia malayi major facilitator superfamily protein 0.0018 0.0061 0.0266
Schistosoma mansoni hypothetical protein 0.0621 0.9142 0.9141
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0329 0.1482
Echinococcus granulosus solute carrier family 22 0.0018 0.0061 0.0061
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0692 0.0692
Mycobacterium leprae POSSIBLE HYDROLASE 0.0079 0.099 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0015 0.0021 0.0021
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1694 0.1694
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Echinococcus multilocularis lamin dm0 0.0026 0.0192 0.0192
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0329 0.0344
Trichomonas vaginalis beta lactamase domain, putative 0.0079 0.099 0.5688
Loa Loa (eye worm) hypothetical protein 0.0023 0.0144 0.0687
Echinococcus multilocularis tyrosine protein kinase Abl 0.0027 0.0194 0.0194
Mycobacterium ulcerans beta lactamase-like protein 0.0079 0.099 1
Trypanosoma brucei glucose transporter, putative 0.0039 0.0383 0.3468
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0128 0.1718 0.1718
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0651 0.6358
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1694 0.1694
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0116 0.1544 0.1544
Onchocerca volvulus 0.0018 0.0061 0.0381
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0383 0.1973
Mycobacterium tuberculosis Possible hydrolase 0.0079 0.099 1
Schistosoma mansoni zinc phosphodiesterase 0.0079 0.099 0.0975
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.1981 0.1981
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0015 0.0021 0.0021
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0086 0.0273
Echinococcus granulosus pyruvate kinase 0.0018 0.0068 0.0068
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0329 0.2891
Loa Loa (eye worm) hypothetical protein 0.0079 0.099 0.4768
Onchocerca volvulus Alhambra homolog 0.003 0.0243 0.1758
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0079 0.099 1
Brugia malayi hypothetical protein 0.0018 0.0061 0.0266
Leishmania major pyruvate kinase 0.0036 0.0329 0.2891
Mycobacterium leprae conserved hypothetical protein 0.0079 0.099 1
Brugia malayi Bromodomain containing protein 0.0035 0.0319 0.1435
Entamoeba histolytica hypothetical protein, conserved 0.0079 0.099 0.8098
Loa Loa (eye worm) inositol-1 0.0075 0.0916 0.4413
Loa Loa (eye worm) hypothetical protein 0.0079 0.099 0.4768
Brugia malayi jmjC domain containing protein 0.0098 0.1265 0.5715
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0458 0.4278
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0007 0.0025
Schistosoma mansoni tyrosine kinase 0.0015 0.0021 0.0004
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0086 0.0273
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0023 0.0144 0.0687
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0139 0.0844
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0027 0.0194 0.0194
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0021 0.0092
Brugia malayi Inositol-1 0.0075 0.0916 0.4138
Loa Loa (eye worm) TK protein kinase 0.0106 0.1396 0.673
Brugia malayi Sugar transporter family protein 0.0126 0.1694 0.7658
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0343 0.0343
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0383 0.1973
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0329 0.158
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.0195 0.0876
Brugia malayi hypothetical protein 0.0018 0.0061 0.0266
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0339 0.0339
Echinococcus multilocularis musashi 0.0026 0.0192 0.0192
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0038 0.0364 0.2511
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0027 0.0194 0.0178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Giardia lamblia Pyruvate kinase 0.0036 0.0329 0.2891
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0079 0.099 0.7413
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0079 0.099 0.4768
Loa Loa (eye worm) hypothetical protein 0.0038 0.0364 0.1746
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0383 0.1973
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0329 0.2414
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0086 0.0381
Echinococcus multilocularis tyrosine protein kinase HCK 0.0095 0.1219 0.1219
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0079 0.099 0.4768
Echinococcus multilocularis c src tyrosine kinase 0.0027 0.0194 0.0194
Onchocerca volvulus 0.0015 0.0021 0.0079
Loa Loa (eye worm) hypothetical protein 0.0082 0.103 0.4965
Mycobacterium tuberculosis Conserved hypothetical protein 0.0079 0.099 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0364 0.0348
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0086 0.0273
Schistosoma mansoni sex comb on midleg homolog 0.0102 0.1331 0.1317
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0343 0.0327
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0243 0.1162
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0079 0.099 0.099
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0079 0.099 0.4768
Leishmania major metallo-beta-lactamase family protein-like protein 0.0079 0.099 1
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0079 0.099 0.447
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0007 0.0024
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0118 0.1569 0.1569
Plasmodium falciparum proline--tRNA ligase 0.0044 0.0458 0.0509
Mycobacterium ulcerans hypothetical protein 0.0079 0.099 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1694 0.1694
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0116 0.0592
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0352 0.0336
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0243 0.0356
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0592 0.0681
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0079 0.099 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0458 0.4278
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0086 0.0273
Loa Loa (eye worm) hypothetical protein 0.0026 0.0185 0.0884
Brugia malayi hypothetical protein 0.0018 0.0061 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0651 0.6358
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0079 0.099 0.1818
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0692 0.0676
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0218 0.0977
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.0651 0.0651
Brugia malayi hypothetical protein 0.0053 0.0592 0.2672
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0061 0.0266
Loa Loa (eye worm) hypothetical protein 0.0039 0.0383 0.1839
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.0651 0.6358
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0077 0.0952 0.0952
Echinococcus multilocularis pyruvate kinase 0.0028 0.0216 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0642 0.0627
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0218 0.0218
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0061 0.0061
Echinococcus granulosus pyruvate kinase 0.0036 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0038 0.0364 0.1746
Giardia lamblia GTOR 0.0019 0.0086 0.0273
Schistosoma mansoni nck2/grb4 0.0023 0.0144 0.0128
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0079 0.099 1
Chlamydia trachomatis ribonuclease Z 0.0079 0.099 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0118 0.1569 0.1569
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0079 0.099 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0218 0.0961
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.099 0.5688
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0039 0.0383 0.0631
Mycobacterium tuberculosis Beta lactamase like protein 0.0079 0.099 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0592 0.285
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0038 0.0364 0.1637
Schistosoma mansoni hypothetical protein 0.0024 0.0152 0.0136
Entamoeba histolytica hypothetical protein 0.0037 0.0352 0.2798
Echinococcus granulosus SAM and MBT domain containing protein 0.0102 0.1331 0.1331
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0039 0.0383 0.1839
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0086 0.005
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0352 0.0352
Onchocerca volvulus 0.0018 0.0061 0.0381
Onchocerca volvulus 0.0018 0.0061 0.0381
Entamoeba histolytica protein kinase, putative 0.0095 0.1219 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0192 0.0919
Echinococcus multilocularis tyrosine protein kinase Srms 0.0106 0.1396 0.1396
Loa Loa (eye worm) hypothetical protein 0.0102 0.1331 0.6417
Echinococcus granulosus intermediate filament protein 0.0026 0.0192 0.0192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0642 0.6257
Schistosoma mansoni hypothetical protein 0.0037 0.0352 0.0336
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0079 0.099 0.099
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0651 0.0636
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.1265 0.1265
Brugia malayi Sex muscle abnormal protein 5 0.0023 0.0144 0.0644
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.1981 0.1981
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0284
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0585 0.2814
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.1981 0.9551
Trypanosoma brucei glucose transporter, putative 0.0039 0.0383 0.3468
Plasmodium falciparum calcium-dependent protein kinase 2 0.0039 0.0383 0.0413
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0383 0.3468
Onchocerca volvulus 0.0018 0.0061 0.0381
Schistosoma mansoni growth factor receptor-bound protein 0.0023 0.0144 0.0128
Loa Loa (eye worm) hypothetical protein 0.0087 0.1107 0.5334
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0015 0.0021 0.0051
Plasmodium vivax unspecified product 0.0079 0.099 0.119
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0038 0.0364 0.0364
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.1981 0.1981
Schistosoma mansoni hypothetical protein 0.0079 0.099 0.0975
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0038 0.0364 0.1637
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0692 0.0692
Loa Loa (eye worm) hypothetical protein 0.0037 0.0343 0.1648
Echinococcus granulosus growth factor receptor bound protein 2 0.0023 0.0144 0.0144
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0039 0.0383 0.3468
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0118 0.1569 0.1569
Loa Loa (eye worm) hypothetical protein 0.0025 0.0167 0.0798
Brugia malayi mbt repeat family protein 0.0102 0.1331 0.6017
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0662
Brugia malayi major facilitator superfamily protein 0.0018 0.0061 0.0266
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0383 0.1973
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1559 0.7517
Loa Loa (eye worm) hypothetical protein 0.0151 0.2074 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0916 0.9209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Trichomonas vaginalis beta lactamase domain, putative 0.0079 0.099 0.5688
Echinococcus multilocularis pyruvate kinase 0.0018 0.0068 0.0068
Brugia malayi PHD-finger family protein 0.0053 0.0597 0.2692
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0343 0.0327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Loa Loa (eye worm) hypothetical protein 0.0079 0.099 0.4768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1981 0.1967
Toxoplasma gondii protein kinase, putative 0.0357 0.517 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.0458 0.0778
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1559 0.7517
Schistosoma mansoni hypothetical protein 0.0126 0.1694 0.168
Echinococcus multilocularis zinc finger protein 0.0042 0.0425 0.0425
Schistosoma mansoni hypothetical protein 0.003 0.0243 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0383 0.1973
Trypanosoma brucei ISWI complex protein 0.0033 0.0287 0.2433
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0383 0.0383
Echinococcus multilocularis pyruvate kinase 0.0036 0.0329 0.0329
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0079 0.099 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0086 0.0086
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0039 0.0383 0.1839
Brugia malayi Bromodomain containing protein 0.0161 0.2211 1
Brugia malayi hypothetical protein 0.0037 0.0352 0.1583
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0692 0.1235
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.1694 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0039 0.0383 0.0413
Plasmodium falciparum phd finger protein, putative 0.003 0.0243 0.0233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0642 0.2897
Onchocerca volvulus 0.0015 0.0021 0.0079
Echinococcus multilocularis inositol monophosphatase 1 0.0075 0.0916 0.0916
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0218 0.169
Mycobacterium ulcerans hydrolase 0.0079 0.099 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0329 0.1482
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.0651 0.6358
Echinococcus multilocularis solute carrier family 22 0.0018 0.0061 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Brugia malayi MH2 domain containing protein 0.0117 0.1559 0.7048
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.099 0.5688
Plasmodium vivax hypothetical protein, conserved 0.003 0.0243 0.0233
Schistosoma mansoni inositol monophosphatase 0.0075 0.0916 0.0901
Schistosoma mansoni sugar transporter 0.0018 0.0061 0.0044
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0383 0.3468
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0075 0.0916 0.1674
Loa Loa (eye worm) TK/ABL protein kinase 0.0015 0.0021 0.0092
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0343 0.0343
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0329 0.0526
Mycobacterium tuberculosis Conserved hypothetical protein 0.0079 0.099 1
Loa Loa (eye worm) SRC-1 0.0118 0.1569 0.7566
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0061 0.0061
Echinococcus granulosus ETHE1 protein 0.0079 0.099 0.099
Mycobacterium leprae conserved hypothetical protein 0.0079 0.099 1
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.099 0.5688
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0086 0.007
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0383 0.0383
Brugia malayi metallo-beta-lactamase superfamily protein 0.0079 0.099 0.447
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0329 0.1644
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0086 0.0086
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0329 0.2891
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0329 0.158
Echinococcus granulosus pyruvate kinase 0.0018 0.0068 0.0068
Entamoeba histolytica metallo-beta-lactamase family protein 0.0079 0.099 0.8098
Trichomonas vaginalis beta lactamase domain, putative 0.0079 0.099 0.5688
Onchocerca volvulus 0.0018 0.0061 0.0381
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0651 0.3616
Onchocerca volvulus 0.0018 0.0061 0.0381
Loa Loa (eye worm) sugar transporter 0.0018 0.0061 0.0284
Mycobacterium tuberculosis Conserved protein 0.0079 0.099 1
Leishmania major glucose transporter, lmgt1 0.0039 0.0383 0.3468
Onchocerca volvulus 0.0102 0.1331 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0086 0.0273
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0592 0.104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Echinococcus multilocularis zinc phosphodiesterase 0.0079 0.099 0.099
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0021 0.0092
Mycobacterium tuberculosis Conserved protein 0.0079 0.099 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0102 0.1331 0.1317
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0021 0.0092
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0068 0.0015
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0079 0.099 0.099
Brugia malayi jmjC domain containing protein 0.004 0.0399 0.1796
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0086 0.0273
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.1981 0.1981
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0916 0.9209
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0027 0.0194 0.0194
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0167 0.0798
Onchocerca volvulus 0.0018 0.0061 0.0381
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0021 0.0092
Echinococcus multilocularis General substrate transporter 0.0108 0.1427 0.1427
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0021 0.0092
Brugia malayi Cam kinase protein 1 0.0039 0.0383 0.1724
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0642 0.0642
Brugia malayi SH2 domain containing protein 0.0015 0.0021 0.0086
Giardia lamblia PHD finger protein 15 0.003 0.0243 0.1959
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0329 0.2891
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0284
Echinococcus multilocularis ETHE1 protein 0.0079 0.099 0.099
Schistosoma mansoni inositol monophosphatase 0.0075 0.0916 0.0901
Plasmodium falciparum cytosolic glyoxalase II 0.0079 0.099 0.119
Plasmodium falciparum calcium-dependent protein kinase 4 0.0039 0.0383 0.0413
Entamoeba histolytica metallo-beta-lactamase family protein 0.0079 0.099 0.8098
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0419 0.0419
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0329 0.21
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Leishmania major hypothetical protein, conserved 0.0033 0.0287 0.2433
Schistosoma mansoni hypothetical protein 0.0079 0.099 0.0975
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0383 0.3468
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0651 0.3616
Trypanosoma cruzi ISWI complex protein 0.0033 0.0287 0.2433
Brugia malayi Sugar transporter family protein 0.0018 0.0061 0.0266
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0721 0.3471
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0383 0.0367
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0692 0.6791
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0128 0.1718 0.1718
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0086 0.0273
Leishmania major metallo-beta-lactamase family-like protein 0.0079 0.099 1
Leishmania major hypothetical protein, conserved 0.0053 0.0592 0.5723
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0204 0.2872 0.5502
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0329 0.2891
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0075 0.0916 0.9209
Entamoeba histolytica hypothetical protein 0.0037 0.0352 0.2798
Loa Loa (eye worm) hypothetical protein 0.0028 0.0218 0.1042
Echinococcus multilocularis microtubule associated protein 2 0.0678 1 1
Entamoeba histolytica type A flavoprotein, putative 0.0079 0.099 0.8098
Brugia malayi MAP kinase sur-1 0.0057 0.0651 0.2939
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1694 0.1694
Echinococcus granulosus solute carrier family 22 0.0018 0.0061 0.0061
Leishmania major glucose transporter, lmgt3 0.0039 0.0383 0.3468
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Entamoeba histolytica metallo-beta-lactamase family protein 0.0079 0.099 0.8098
Schistosoma mansoni pyruvate kinase 0.0036 0.0329 0.0313
Trypanosoma brucei glucose transporter, putative 0.0039 0.0383 0.3468
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.099 0.5688
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0015 0.0021 0.0021
Schistosoma mansoni glucose transport protein 0.0126 0.1694 0.168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0118 0.1569 0.1569
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0284
Schistosoma mansoni tyrosine kinase 0.0027 0.0194 0.0178
Leishmania major pyruvate kinase 0.0036 0.0329 0.2891
Mycobacterium ulcerans hydrolase 0.0079 0.099 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0284
Echinococcus granulosus General substrate transporter 0.0108 0.1427 0.1427
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0642 0.6257
Plasmodium falciparum pyruvate kinase 0.0036 0.0329 0.0344
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0218 0.169
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0642 0.6257
Echinococcus multilocularis pyruvate kinase 0.0018 0.0068 0.0068
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0039 0.0383 0.1724
Brugia malayi Protein kinase domain containing protein 0.0015 0.0021 0.0086
Schistosoma mansoni growth factor receptor-bound protein 0.0023 0.0144 0.0128
Plasmodium falciparum calcium-dependent protein kinase 5 0.0039 0.0383 0.0413
Onchocerca volvulus 0.0018 0.0061 0.0381
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0086 0.0273
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0152 0.0152
Brugia malayi metallo-beta-lactamase superfamily protein 0.0079 0.099 0.447
Echinococcus granulosus tyrosine protein kinase Fyn 0.0118 0.1569 0.1569
Plasmodium vivax CDK-related protein kinase 6, putative 0.0536 0.7867 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0383 0.3468
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0116 0.1544 0.698
Entamoeba histolytica hypothetical protein 0.0027 0.0195 0.15
Trichomonas vaginalis beta lactamase domain, putative 0.0079 0.099 0.5688
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0079 0.099 0.0975
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0087 0.0279
Echinococcus multilocularis NCK adaptor protein 0.0023 0.0144 0.0144
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.0651 0.0651
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.003 0.0243 0.1162
Loa Loa (eye worm) hypothetical protein 0.0116 0.1544 0.7445
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0284
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0038 0.0364 0.2898
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0284
Echinococcus multilocularis pyruvate kinase 0.0018 0.0068 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0086 0.0155
Brugia malayi intermediate filament protein 0.0026 0.0192 0.0862
Onchocerca volvulus 0.0015 0.0021 0.0079
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0086 0.0592
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0243 0.0227
Echinococcus multilocularis solute carrier family 22 0.0018 0.0061 0.0061
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0383 0.3468
Echinococcus granulosus tyrosine protein kinase Blk 0.0106 0.1396 0.1396
Entamoeba histolytica protein kinase, putative 0.0039 0.0383 0.3057
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0284
Schistosoma mansoni hypothetical protein 0.0079 0.099 0.0975
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0218 0.169
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0086 0.0273
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0192 0.0919
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0329 0.2414
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0284
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0204 0.2872 0.3601
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0079 0.099 0.8098
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0086 0.0086
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0021 0.0092
Brugia malayi ethe1-prov protein 0.0079 0.099 0.447
Brugia malayi Protein kinase domain containing protein 0.0015 0.0021 0.0086
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.052 0.052
Plasmodium falciparum protein kinase 6 0.0536 0.7867 1
Echinococcus multilocularis polycomb protein SCMH1 0.0102 0.1331 0.1331
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0154 0.1002
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.052 0.052
Entamoeba histolytica hypothetical protein 0.0037 0.0352 0.2798
Trypanosoma brucei glucose transporter 2A 0.0039 0.0383 0.3468
Echinococcus granulosus lamin dm0 0.0026 0.0192 0.0192
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0383 0.3468
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0079 0.099 1
Trypanosoma brucei glucose transporter, putative 0.0039 0.0383 0.3468
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0086 0.0273
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0458 0.4278
Giardia lamblia Prolyl-tRNA synthetase 0.0038 0.0364 0.3261
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0079 0.099 1
Onchocerca volvulus Putative hydrolase PNKD 0.0079 0.099 0.7413

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 10 uM Huh7 cytotoxicity for Pf inhibitors Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.1748 uM PF proliferation inhibition 3D7 Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.2354 uM W2 Pf proliferation inhibition Novartis-GNF Malaria Box. No reference
IFI promiscuity index = 0 IFI promiscuity index Novartis-GNF Malaria Box. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.