Detailed information for compound 674361

Basic information

Technical information
  • TDR Targets ID: 674361
  • Name: 3-[[2-chloro-4-[(E)-[3-(2-ethoxy-2-oxoethyl)- 2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]ph enoxy]methyl]benzoic acid
  • MW: 475.899 | Formula: C22H18ClNO7S
  • H donors: 1 H acceptors: 5 LogP: 4.29 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)CN1C(=O)S/C(=C/c2ccc(c(c2)Cl)OCc2cccc(c2)C(=O)O)/C1=O
  • InChi: 1S/C22H18ClNO7S/c1-2-30-19(25)11-24-20(26)18(32-22(24)29)10-13-6-7-17(16(23)9-13)31-12-14-4-3-5-15(8-14)21(27)28/h3-10H,2,11-12H2,1H3,(H,27,28)/b18-10+
  • InChiKey: UFOYDFYCHWKXGW-VCHYOVAHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[2-chloro-4-[(E)-[3-(2-ethoxy-2-oxo-ethyl)-2,4-dioxo-thiazolidin-5-ylidene]methyl]phenoxy]methyl]benzoic acid
  • 3-[[2-chloro-4-[(E)-[3-(2-ethoxy-2-oxoethyl)-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]benzoic acid
  • 3-[[2-chloro-4-[(E)-[3-(2-ethoxy-2-keto-ethyl)-2,4-diketo-thiazolidin-5-ylidene]methyl]phenoxy]methyl]benzoic acid
  • 3-[[2-chloro-4-[(E)-[3-(2-ethoxy-2-oxo-ethyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]phenoxy]methyl]benzoic acid
  • STK151944

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cpg binding protein 0.0072 0.0331 0.0386
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0024 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.025 0.0552
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0704 0.3962 1
Onchocerca volvulus 0.0081 0.0387 0.0665
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0077 0.0089
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.006
Echinococcus multilocularis survival motor neuron protein 1 0.0272 0.1482 0.1482
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0077 0.0359 0.2933
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.0387 0.3167
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.0234
Entamoeba histolytica hypothetical protein 0.0074 0.0347 0.7208
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0223 0.1197 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0626 0.3511 1
Leishmania major hypothetical protein, conserved 0.0081 0.0387 0.3167
Echinococcus multilocularis neuropeptide receptor A26 0.0524 0.293 0.293
Loa Loa (eye worm) hypothetical protein 0.0081 0.0387 0.0977
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0027 0.0069
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0315 0.7913
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0081
Trichomonas vaginalis helicase, putative 0.0015 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.004 0.0151 0.0381
Brugia malayi YY1-associated factor 2 0.0223 0.1197 0.3021
Onchocerca volvulus 0.0102 0.0506 0.0934
Echinococcus granulosus histone lysine methyltransferase setb 0.012 0.0609 0.0609
Schistosoma mansoni zinc finger protein 0.0016 0.0012 0.0013
Onchocerca volvulus 0.0801 0.452 1
Echinococcus multilocularis microtubule associated protein 2 0.1507 0.8573 0.8573
Brugia malayi beta-lactamase family protein 0.0081 0.0387 0.0976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0105 0.0231
Echinococcus multilocularis ring and YY1 binding protein 0.0223 0.1197 0.1197
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0225 0.0568
Loa Loa (eye worm) hypothetical protein 0.0074 0.0346 0.0873
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0105 0.0231
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0005 0.0011
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0012 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0217 0.048
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.0387 0.0856
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0142 0.0736 0.1857
Brugia malayi hypothetical protein 0.0272 0.1482 0.374
Brugia malayi F/Y-rich N-terminus family protein 0.0026 0.0068 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0005 0.0011
Brugia malayi brahma associated protein 60 kDa 0.0626 0.3511 0.8861
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0032 0.0105 0.0104
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.004 0.004
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0223 0.1197 0.3358
Loa Loa (eye worm) Smad1 0.0026 0.0067 0.0168
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0032 0.0105 0.0104
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.0387 0.0856
Schistosoma mansoni hypothetical protein 0.0053 0.0225 0.0263
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0044 0.0111
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0024 0.0103
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0238 0.0601
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0105 0.0264
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0046 0.0181 0.1426
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0018 0.0024 0.0103
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0223 0.1197 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0067 0.0066
Onchocerca volvulus 0.0081 0.0387 0.0665
Brugia malayi hypothetical protein 0.0507 0.2828 0.7137
Echinococcus granulosus Smad4 0.0026 0.0067 0.0066
Loa Loa (eye worm) hypothetical protein 0.0223 0.1197 0.3021
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0225 0.0225
Schistosoma mansoni hypothetical protein 0.0626 0.3511 0.4095
Brugia malayi intermediate filament protein 0.003 0.0093 0.0234
Brugia malayi latrophilin 2 splice variant baaae 0.0115 0.0581 0.1465
Giardia lamblia GTOR 0.0096 0.0472 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0096 0.0472 0.055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0609 0.071
Echinococcus multilocularis cpg binding protein 0.0072 0.0331 0.0331
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0609 0.071
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0018 0.0024 0.0024
Schistosoma mansoni cpg binding protein 0.0066 0.0298 0.0347
Echinococcus multilocularis tumor protein p63 0.1756 1 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.0736 0.1857
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0387 0.0856
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0223 0.1197 1
Schistosoma mansoni hypothetical protein 0.0192 0.1023 0.1192
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.0225 0.0225
Leishmania major hypothetical protein, conserved 0.0223 0.1197 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0081 0.0387 0.1249
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0067 0.0168
Brugia malayi hypothetical protein 0.0142 0.0736 0.1856
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0145 0.0169
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0018 0.0024 0.0103
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.004 0.004
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.004 0.0101
Trypanosoma cruzi hypothetical protein, conserved 0.0223 0.1197 1
Loa Loa (eye worm) hypothetical protein 0.0168 0.0887 0.2238
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0096 0.0472 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.004 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.025 0.0552
Echinococcus granulosus neuropeptide s receptor 0.0524 0.293 0.293
Loa Loa (eye worm) hypothetical protein 0.0081 0.0387 0.0977
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.033 0.073
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0064 0.0104
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.004 0.5
Echinococcus multilocularis lamin dm0 0.003 0.0093 0.0093
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.004 0.0242
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0008
Brugia malayi PHD-finger family protein 0.003 0.0091 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0005 0.0011
Onchocerca volvulus 0.0223 0.1197 0.2494
Mycobacterium tuberculosis Probable lipase LipD 0.0081 0.0387 0.1249
Loa Loa (eye worm) hypothetical protein 0.0507 0.2828 0.7137
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0626 0.3511 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0005 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.033 0.073
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0022 0.0022
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0626 0.3511 0.3511
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0064 0.0104
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0347 0.0347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0218 0.0481
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0081 0.0387 0.0976
Schistosoma mansoni microtubule-associated protein tau 0.1507 0.8573 1
Schistosoma mansoni cellular tumor antigen P53 0.0257 0.1395 0.1627
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0105 0.0231
Loa Loa (eye worm) hypothetical protein 0.0223 0.1197 0.3021
Mycobacterium tuberculosis Conserved protein 0.0081 0.0387 0.1249
Loa Loa (eye worm) hypothetical protein 0.0081 0.0387 0.0977
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0347 0.0347
Plasmodium vivax hypothetical protein, conserved 0.0626 0.3511 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0093 0.0234
Trypanosoma cruzi hypothetical protein, conserved 0.0223 0.1197 1
Mycobacterium tuberculosis Probable esterase LipL 0.0081 0.0387 0.1249
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.004 0.0038
Mycobacterium ulcerans beta-lactamase 0.0081 0.0387 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0018 0.0024 0.0028
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.004 0.0089
Schistosoma mansoni ap endonuclease 0.0021 0.004 0.0047
Mycobacterium tuberculosis Probable hydrolase 0.0081 0.0387 0.1249
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.0315 0.0998
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.004 0.5
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0026 0.0066
Brugia malayi Bromodomain containing protein 0.004 0.015 0.0379
Brugia malayi beta-lactamase family protein 0.0081 0.0387 0.0976
Echinococcus multilocularis SWI:SNF matrix associated 0.0626 0.3511 0.3511
Onchocerca volvulus 0.0626 0.3511 0.7721
Mycobacterium leprae Probable lipase LipE 0.0081 0.0387 0.5
Onchocerca volvulus 0.0223 0.1197 0.2494
Toxoplasma gondii exonuclease III APE 0.0021 0.004 0.0047
Schistosoma mansoni hypothetical protein 0.0626 0.3511 0.4095
Brugia malayi Pre-SET motif family protein 0.0704 0.3962 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.0105 0.0785
Toxoplasma gondii ABC1 family protein 0.0081 0.0387 0.1041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0246 0.0544
Brugia malayi Pre-SET motif family protein 0.0102 0.0506 0.1278
Brugia malayi hypothetical protein 0.0025 0.0064 0.016
Loa Loa (eye worm) hypothetical protein 0.0049 0.0198 0.05
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0096 0.0472 0.0472
Trichomonas vaginalis esterase, putative 0.0081 0.0387 0.0856
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0024 0.0052
Brugia malayi Calcitonin receptor-like protein seb-1 0.0168 0.0887 0.2237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0391 0.0865
Brugia malayi MH1 domain containing protein 0.0014 0.0001 0.0001
Onchocerca volvulus 0.0507 0.2828 0.6178
Loa Loa (eye worm) hypothetical protein 0.0223 0.1197 0.3021
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0081 0.0387 0.0977
Loa Loa (eye worm) phosphatidylinositol 3 0.0096 0.0472 0.1191
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0022 0.0026
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0919 0.5198 0.5198
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0027 0.001
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0081 0.0387 0.1249
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0067 0.0066
Mycobacterium tuberculosis Conserved protein 0.0081 0.0387 0.1249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.033 0.073
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0067 0.0168
Mycobacterium ulcerans esterase/lipase LipP 0.0081 0.0387 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.004 0.0149 0.1158
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0058 0.0058
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0032 0.0105 0.0785
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0013
Onchocerca volvulus 0.0081 0.0387 0.0665
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0626 0.3511 0.8861
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0096 0.0472 0.3882
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.004 0.0038
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.0298 0.0752
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.025 0.0552
Mycobacterium tuberculosis Probable lipase LipE 0.0081 0.0387 0.1249
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0067 0.0066
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0005 0.0011
Trypanosoma brucei hypothetical protein, conserved 0.0081 0.0387 0.3167
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0067 0.0066
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0223 0.1197 0.3021
Loa Loa (eye worm) hypothetical protein 0.0081 0.0387 0.0977
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.004 0.0242
Echinococcus granulosus neuropeptide receptor A26 0.0524 0.293 0.293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0246 0.0544
Schistosoma mansoni hypothetical protein 0.0074 0.0347 0.0404
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0005 0.0011
Echinococcus multilocularis neuropeptide s receptor 0.0524 0.293 0.293
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0223 0.1197 1
Schistosoma mansoni hypothetical protein 0.0022 0.0044 0.0051
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0018 0.0024 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0223 0.1197 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0223 0.1197 0.3021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0168 0.0887 0.2238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0217 0.048
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0126 0.0126
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0027 0.0068
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.0074 0.0347 0.7208
Brugia malayi MH2 domain containing protein 0.0376 0.2079 0.5246
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.0387 0.0451
Loa Loa (eye worm) histone methyltransferase 0.0024 0.0058 0.0146
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0027 0.0032
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0096 0.0472 0.3882
Entamoeba histolytica hypothetical protein 0.0074 0.0347 0.7208
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0005 0.0011
Echinococcus multilocularis beta LACTamase domain containing family member 0.0081 0.0387 0.0387
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0126 0.0126
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0626 0.3511 1
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.0387 0.3167
Echinococcus multilocularis SWI:SNF matrix associated 0.0626 0.3511 0.3511
Schistosoma mansoni lamin 0.003 0.0093 0.0108
Schistosoma mansoni hypothetical protein 0.0115 0.0581 0.0677
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0005 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0359 0.0793
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0301 0.0301
Brugia malayi MH1 domain containing protein 0.0026 0.0067 0.0167
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0027 0.0132
Onchocerca volvulus 0.0223 0.1197 0.2494
Echinococcus multilocularis geminin 0.0192 0.1023 0.1022
Loa Loa (eye worm) beta-lactamase 0.0081 0.0387 0.0977
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.0105 0.0785
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0064 0.0104
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.004 0.0089
Echinococcus granulosus survival motor neuron protein 1 0.0272 0.1482 0.1482
Schistosoma mansoni TRABID protein (C64 family) 0.0223 0.1197 0.1396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.033 0.073
Schistosoma mansoni smad1 5 8 and 0.0026 0.0067 0.0077
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.004 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.033 0.073
Loa Loa (eye worm) hypothetical protein 0.0223 0.1197 0.3021
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0223 0.1197 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0068 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.033 0.073
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0626 0.3511 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0081 0.0387 0.0387
Echinococcus multilocularis mixed lineage leukemia protein mll 0.002 0.0035 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0278 0.0615
Echinococcus granulosus serine protein kinase ATM 0.0018 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.016
Echinococcus granulosus zinc finger protein 0.0024 0.0059 0.0059
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0027 0.0027
Brugia malayi brahma associated protein 60 kDa 0.0626 0.3511 0.8861
Echinococcus multilocularis dnaJ subfamily B 0.0938 0.5307 0.5307
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0032 0.0105 0.0785
Schistosoma mansoni hypothetical protein 0.0053 0.0225 0.0263
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0035 0.0034
Toxoplasma gondii non-specific serine/threonine protein kinase 0.002 0.0036 0.0034
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0022 0.0022
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0626 0.3511 0.3511
Schistosoma mansoni hypothetical protein 0.0192 0.1023 0.1192
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0223 0.1197 0.3364
Mycobacterium leprae conserved hypothetical protein 0.0081 0.0387 0.5
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.004 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0005 0.0011
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.012 0.0609 0.0609
Schistosoma mansoni hypothetical protein 0.0053 0.0225 0.0263
Brugia malayi isocitrate dehydrogenase 0.0019 0.0027 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0005 0.0011
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0136 0.0136
Echinococcus multilocularis musashi 0.003 0.0093 0.0093
Onchocerca volvulus 0.0066 0.0298 0.0463
Onchocerca volvulus 0.0056 0.0238 0.0328
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.0315 0.0834
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0249
Schistosoma mansoni zinc finger protein 0.0024 0.0059 0.0069
Toxoplasma gondii ran binding protein 0.0223 0.1197 0.3364
Trypanosoma cruzi target of rapamycin kinase 3 0.0077 0.0359 0.2933
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0005 0.0011
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.0315 0.0315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0472 0.1044
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0027 0.0027
Echinococcus granulosus cpg binding protein 0.0072 0.0331 0.0331
Echinococcus granulosus microtubule associated protein 2 0.1507 0.8573 0.8573
Schistosoma mansoni hypothetical protein 0.0626 0.3511 0.4095
Loa Loa (eye worm) hypothetical protein 0.0257 0.1395 0.3521
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0223 0.1197 0.3021
Loa Loa (eye worm) transcription factor SMAD2 0.0376 0.2079 0.5246
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0005 0.0011
Schistosoma mansoni bromodomain containing protein 0.007 0.0323 0.0376
Echinococcus granulosus intermediate filament protein 0.003 0.0093 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0359 0.0793
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0005 0.0011
Schistosoma mansoni hypothetical protein 0.0938 0.5307 0.619
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0036 0.0079
Brugia malayi Smad1 0.0026 0.0067 0.0167
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0027 0.0027
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0387 0.0856
Schistosoma mansoni fkbp-rapamycin associated protein 0.0018 0.0024 0.0028
Echinococcus granulosus Zinc finger RanBP2 type 0.0223 0.1197 0.1197
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0223 0.1197 0.1197
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0003 0.0003
Mycobacterium tuberculosis Conserved protein 0.0081 0.0387 0.1249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.029 0.0641
Leishmania major hypothetical protein, conserved 0.0025 0.0064 0.0437
Brugia malayi beta-lactamase 0.0081 0.0387 0.0976
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0112 0.0248
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0225 0.0569
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0096 0.0472 0.3882
Echinococcus multilocularis SWI:SNF matrix associated 0.0626 0.3511 0.3511
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0032 0.0105 0.0785
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0102 0.0506 0.059
Echinococcus granulosus smad 0.0026 0.0067 0.0066
Trypanosoma brucei hypothetical protein, conserved 0.0223 0.1197 1
Loa Loa (eye worm) hypothetical protein 0.0223 0.1197 0.3021
Echinococcus multilocularis GPCR, family 2 0.0053 0.0225 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0105 0.0231
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0225 0.0225
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.0387 0.0451
Chlamydia trachomatis SWIB complex protein 0.0626 0.3511 0.5
Onchocerca volvulus Huntingtin homolog 0.0142 0.0736 0.1452
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0472 0.1044
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0225 0.0568
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0081 0.0387 0.1249
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0347 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0024 0.0052
Toxoplasma gondii target of rapamycin (TOR), putative 0.0072 0.033 0.0879
Loa Loa (eye worm) hypothetical protein 0.0081 0.0387 0.0977
Echinococcus multilocularis serine protein kinase ATM 0.0018 0.0024 0.0024
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0096 0.0472 0.3882
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0102 0.0506 0.059
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0096 0.0472 0.0472
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0315 0.0367
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0027 0.0027
Mycobacterium ulcerans hypothetical protein 0.0081 0.0387 1
Echinococcus multilocularis zinc finger protein Ran binding 0.0223 0.1197 0.1197
Leishmania major hypothetical protein, conserved 0.0223 0.1197 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0058 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0359 0.0793
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0012 0.0031
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.004 0.0368
Loa Loa (eye worm) nuclear factor I 0.0014 0.0001 0.0002
Loa Loa (eye worm) brahma associated protein 0.0626 0.3511 0.8861
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0126 0.0317
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0027 0.0132
Schistosoma mansoni zinc finger protein 0.0223 0.1197 0.1396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0359 0.0793
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0626 0.3511 1
Echinococcus multilocularis zinc finger protein 0.0024 0.0059 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.033 0.073
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0223 0.1197 1
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0093 0.0234
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0143 0.0743 0.0867
Trypanosoma brucei hypothetical protein, conserved 0.0223 0.1197 1
Entamoeba histolytica hypothetical protein 0.0074 0.0347 0.7208
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0168 0.0887 0.2237
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0077 0.0359 0.2933
Leishmania major hypothetical protein, conserved 0.0223 0.1197 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0027 0.0132
Mycobacterium tuberculosis Possible penicillin-binding protein 0.052 0.2907 1
Trichomonas vaginalis conserved hypothetical protein 0.0626 0.3511 0.7768
Toxoplasma gondii histone lysine methyltransferase SET1 0.0131 0.0672 0.1858
Echinococcus granulosus GPCR family 2 0.0053 0.0225 0.0225
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0077 0.0077
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0096 0.0472 0.3882
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0387 0.0856
Loa Loa (eye worm) hypothetical protein 0.0081 0.0387 0.0977
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0223 0.1197 1
Schistosoma mansoni RNA binding protein 0.0223 0.1197 0.1396
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0022 0.0026
Echinococcus granulosus geminin 0.0192 0.1023 0.1022
Schistosoma mansoni smad1 5 8 and 0.0026 0.0067 0.0077
Brugia malayi MH2 domain containing protein 0.0026 0.0067 0.0167
Echinococcus granulosus ring and YY1 binding protein 0.0223 0.1197 0.1197
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.0225 0.0225
Trypanosoma cruzi WLM domain containing protein, putative 0.0223 0.1197 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.004 0.0242
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0064 0.0114
Loa Loa (eye worm) hypothetical protein 0.0053 0.0225 0.0569
Onchocerca volvulus 0.0223 0.1197 0.2494
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0315 0.7913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0218 0.0481
Echinococcus multilocularis Smad4 0.0026 0.0067 0.0066
Brugia malayi CXXC zinc finger family protein 0.0066 0.0298 0.0751
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0027 0.0132
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0003 0.0003
Echinococcus multilocularis lamin 0.003 0.0093 0.0093
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0096 0.0472 0.119
Brugia malayi MH1 domain containing protein 0.0026 0.0067 0.0167
Echinococcus granulosus dnaJ subfamily B 0.0938 0.5307 0.5307
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0102 0.0506 0.1384
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0096 0.0472 0.3882
Schistosoma mansoni survival motor neuron protein 0.0056 0.0238 0.0278
Schistosoma mansoni hypothetical protein 0.0223 0.1197 0.1396
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0027 0.001
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0223 0.1197 0.1197
Mycobacterium ulcerans lipase LipD 0.0081 0.0387 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.002 0.0035 0.0034
Trichomonas vaginalis set domain proteins, putative 0.0801 0.452 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0315 0.7913
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0064 0.0437
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0081 0.0387 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0217 0.048
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0097 0.0477 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0359 0.0793
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0105 0.0231
Schistosoma mansoni lamin 0.003 0.0093 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0218 0.0481
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0145 0.0169
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0112 0.0248
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0035 0.004
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0315 0.0367
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0301 0.0301
Echinococcus granulosus zinc finger protein Ran binding 0.0223 0.1197 0.1197
Brugia malayi MH2 domain containing protein 0.0026 0.0067 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0218 0.0481
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0223 0.1197 0.3021
Schistosoma mansoni Smad4 0.0026 0.0067 0.0077
Echinococcus granulosus SWI:SNF matrix associated 0.0626 0.3511 0.3511
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0064 0.0437
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0035 0.0034
Schistosoma mansoni ap endonuclease 0.0021 0.004 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0005 0.0011
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0077 0.0077
Schistosoma mansoni brg-1 associated factor 0.0626 0.3511 0.4095
Schistosoma mansoni smad 0.0026 0.0067 0.0077
Brugia malayi Bromodomain containing protein 0.0083 0.0393 0.0992
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0024 0.006
Loa Loa (eye worm) hypothetical protein 0.0115 0.0581 0.1465
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0005 0.0011
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0126 0.0318
Echinococcus granulosus lamin 0.003 0.0093 0.0093
Echinococcus granulosus lamin dm0 0.003 0.0093 0.0093
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0102 0.0506 0.0506
Loa Loa (eye worm) hypothetical protein 0.003 0.009 0.0226
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0091
Schistosoma mansoni cpg binding protein 0.0072 0.0331 0.0386
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0064 0.0437
Brugia malayi SWIB/MDM2 domain containing protein 0.0626 0.3511 0.8861
Loa Loa (eye worm) hypothetical protein 0.012 0.0609 0.1538
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.0315 0.2557
Loa Loa (eye worm) hypothetical protein 0.0272 0.1482 0.3741
Leishmania major hypothetical protein, conserved 0.0223 0.1197 1
Plasmodium vivax SET domain protein, putative 0.0102 0.0506 0.1375
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0032 0.0105 0.0122
Schistosoma mansoni hypothetical protein 0.0056 0.0238 0.0278
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0005 0.0011
Schistosoma mansoni fusion 0.0223 0.1197 0.1396
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0027 0.0132
Onchocerca volvulus Huntingtin homolog 0.0142 0.0736 0.1452
Brugia malayi hypothetical protein 0.0074 0.0347 0.0875
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0096 0.0472 1
Chlamydia trachomatis DNA topoisomerase I 0.0626 0.3511 0.5
Loa Loa (eye worm) intermediate filament protein 0.003 0.0093 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0005 0.0011
Leishmania major phosphatidylinositol 3-kinase, putative 0.0032 0.0105 0.0785
Loa Loa (eye worm) MH2 domain-containing protein 0.0376 0.2079 0.5246
Schistosoma mansoni hypothetical protein 0.0053 0.0225 0.0263
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0067 0.0077
Schistosoma mansoni smad1 5 8 and 0.0026 0.0067 0.0077
Brugia malayi hypothetical protein 0.0016 0.0012 0.0031
Loa Loa (eye worm) hypothetical protein 0.0043 0.0165 0.0417
Onchocerca volvulus 0.0257 0.1395 0.2941
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0223 0.1197 0.2494
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0024 0.0052
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0223 0.1197 0.1197
Echinococcus multilocularis smad 0.0026 0.0067 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0472 0.1044
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0027 0.0027
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.0315 0.0315
Trypanosoma cruzi WLM domain containing protein, putative 0.0223 0.1197 1
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0387 0.1033
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0105 0.0264
Leishmania major hypothetical protein, conserved 0.0223 0.1197 1
Brugia malayi MH1 domain containing protein 0.0014 0.0001 0.0001
Schistosoma mansoni intermediate filament proteins 0.003 0.0093 0.0108

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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