Detailed information for compound 674397

Basic information

Technical information
  • TDR Targets ID: 674397
  • Name: N-(3-chloro-4-pyrrolidin-1-ylphenyl)-2-iodobe nzamide
  • MW: 426.679 | Formula: C17H16ClIN2O
  • H donors: 1 H acceptors: 1 LogP: 4.65 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1I)Nc1ccc(c(c1)Cl)N1CCCC1
  • InChi: 1S/C17H16ClIN2O/c18-14-11-12(7-8-16(14)21-9-3-4-10-21)20-17(22)13-5-1-2-6-15(13)19/h1-2,5-8,11H,3-4,9-10H2,(H,20,22)
  • InChiKey: IZMHDPDILQVZFL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-chloro-4-pyrrolidin-1-yl-phenyl)-2-iodo-benzamide
  • N-(3-chloro-4-1-pyrrolidinylphenyl)-2-iodobenzamide
  • Oprea1_175908

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni lamin 0.0029 0.0076 0.0105
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0146 0.0641 0.0891
Onchocerca volvulus 0.0251 0.1152 0.2952
Entamoeba histolytica hypothetical protein 0.0073 0.0288 0.7354
Loa Loa (eye worm) hypothetical protein 0.0164 0.073 0.2173
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0251 0.1152 0.1152
Trypanosoma cruzi target of rapamycin kinase 3 0.0074 0.0293 0.2464
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0025 0.0114
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0509 0.2408 1
Brugia malayi SWIB/MDM2 domain containing protein 0.0705 0.3357 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0133 0.058 0.1678
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0186 0.0553
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0093 0.0384 0.0534
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0067 0.0067
Mycobacterium tuberculosis Conserved protein 0.008 0.0322 0.1245
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.008 0.0322 0.0957
Onchocerca volvulus 0.0251 0.1152 0.2952
Schistosoma mansoni RNA binding protein 0.0251 0.1152 0.16
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0058
Schistosoma mansoni hypothetical protein 0.02 0.0905 0.1257
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0055 0.0382
Echinococcus granulosus Smad4 0.0026 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0052 0.0186 0.0258
Leishmania major hypothetical protein, conserved 0.0251 0.1152 1
Trypanosoma brucei hypothetical protein, conserved 0.0251 0.1152 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0033 0.0024
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0055 0.0108
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0251 0.1152 0.3431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0269 0.0723
Schistosoma mansoni smad 0.0026 0.0059 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0177 0.0476
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0255 0.0255
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0025 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0384 0.1033
Echinococcus multilocularis musashi 0.0029 0.0076 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0008 0.0021
Echinococcus granulosus dnaJ subfamily B 0.0953 0.4563 0.4563
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0059 0.0176
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.01 0.0418 0.0418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0384 0.1033
Schistosoma mansoni survival motor neuron protein 0.0053 0.0193 0.0268
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0025 0.0016
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0251 0.1152 0.3393
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0251 0.1152 0.1152
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0025 0.0025
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.008 0.0322 1
Trichomonas vaginalis set domain proteins, putative 0.078 0.3721 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0055 0.0092
Echinococcus granulosus beta LACTamase domain containing family member 0.008 0.0322 0.0321
Schistosoma mansoni bromodomain containing protein 0.007 0.0273 0.0379
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0177 0.0475
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0094 0.0393 0.0393
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0074 0.0293 0.2464
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0177 0.0475
Echinococcus granulosus lamin 0.0029 0.0076 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0085 0.0229
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0129 0.0179
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0101 0.0272
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0033 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0269 0.0723
Brugia malayi CXXC zinc finger family protein 0.0067 0.0259 0.0772
Trypanosoma cruzi WLM domain containing protein, putative 0.0251 0.1152 1
Brugia malayi Smad1 0.0026 0.0059 0.0175
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0177 0.0476
Loa Loa (eye worm) hypothetical protein 0.0251 0.1152 0.3431
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0059 0.0059
Schistosoma mansoni brg-1 associated factor 0.0705 0.3357 0.4663
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0055 0.0382
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0008 0.0021
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0033 0.0185
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0033 0.0097
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0705 0.3357 0.4663
Brugia malayi F/Y-rich N-terminus family protein 0.0026 0.0061 0.0181
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.002 0.0058
Brugia malayi latrophilin 2 splice variant baaae 0.0112 0.0478 0.1423
Brugia malayi Bromodomain containing protein 0.0082 0.0333 0.099
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0008 0.0021
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0113 0.0337
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0076 0.0225
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.01 0.0418 0.058
Echinococcus granulosus intermediate filament protein 0.0029 0.0076 0.0075
Echinococcus multilocularis lamin 0.0029 0.0076 0.0075
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0033 0.0033
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0055 0.0092
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0282 0.8635
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0705 0.3357 0.3357
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.0504 0.07
Toxoplasma gondii target of rapamycin (TOR), putative 0.0069 0.0269 0.0748
Schistosoma mansoni cellular tumor antigen P53 0.0303 0.1408 0.1955
Trypanosoma cruzi hypothetical protein, conserved 0.0251 0.1152 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.01 0.0418 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0085 0.0229
Onchocerca volvulus 0.0053 0.0193 0.0323
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0008 0.0021
Echinococcus granulosus zinc finger protein Ran binding 0.0251 0.1152 0.1152
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0025 0.0074
Loa Loa (eye worm) hypothetical protein 0.0141 0.0619 0.1845
Entamoeba histolytica hypothetical protein 0.0073 0.0288 0.7354
Schistosoma mansoni hypothetical protein 0.0705 0.3357 0.4663
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0093 0.0384 0.3269
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0029 0.0073 0.0218
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0085 0.0645
Brugia malayi MH2 domain containing protein 0.0377 0.1764 0.5255
Schistosoma mansoni hypothetical protein 0.0052 0.0186 0.0258
Brugia malayi hypothetical protein 0.0016 0.0013 0.0037
Schistosoma mansoni smad1 5 8 and 0.0026 0.0059 0.0082
Brugia malayi MH1 domain containing protein 0.0026 0.0059 0.0175
Echinococcus multilocularis survival motor neuron protein 1 0.0262 0.1204 0.1204
Onchocerca volvulus 0.0251 0.1152 0.2952
Loa Loa (eye worm) hypothetical protein 0.0042 0.0141 0.0419
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.002 0.0052
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0251 0.1152 0.1152
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0093 0.0384 0.3269
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0059 0.0059
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0269 0.0723
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0251 0.1152 1
Mycobacterium tuberculosis Probable esterase LipL 0.008 0.0322 0.1245
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0031 0.0085 0.0085
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0251 0.1152 1
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Echinococcus granulosus lamin dm0 0.0029 0.0076 0.0075
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0031 0.0085 0.0645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0055 0.0148
Toxoplasma gondii exonuclease III APE 0.002 0.0033 0.004
Onchocerca volvulus 0.0303 0.1408 0.3654
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0282 0.8635
Echinococcus granulosus Zinc finger RanBP2 type 0.0251 0.1152 0.1152
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0059 0.0059
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0033 0.0185
Echinococcus granulosus cpg binding protein 0.0073 0.0288 0.0287
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0251 0.1152 1
Schistosoma mansoni fusion 0.0251 0.1152 0.16
Brugia malayi MH1 domain containing protein 0.0026 0.0059 0.0175
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0705 0.3357 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0282 0.8635
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0322 0.2716
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0033 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0227 0.0608
Schistosoma mansoni fkbp-rapamycin associated protein 0.0018 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0165
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0052 0.0052
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0025 0.0025
Echinococcus multilocularis SWI:SNF matrix associated 0.0705 0.3357 0.3357
Schistosoma mansoni hypothetical protein 0.0953 0.4563 0.6339
Echinococcus granulosus GPCR family 2 0.0052 0.0186 0.0186
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0031 0.0085 0.0118
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0033 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0087
Echinococcus multilocularis serine protein kinase ATM 0.0018 0.002 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0705 0.3357 0.9022
Echinococcus granulosus geminin 0.02 0.0905 0.0905
Brugia malayi beta-lactamase family protein 0.008 0.0322 0.0957
Toxoplasma gondii non-specific serine/threonine protein kinase 0.002 0.0029 0.0029
Echinococcus multilocularis ring and YY1 binding protein 0.0251 0.1152 0.1152
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0008 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.0504 0.07
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0186 0.0186
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0025 0.0114
Loa Loa (eye worm) hypothetical protein 0.0029 0.0076 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0008 0.0021
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0113 0.0113
Onchocerca volvulus 0.0067 0.0259 0.0504
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0193 0.0576
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0282 0.0392
Echinococcus granulosus zinc finger protein 0.0024 0.0052 0.0052
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0085 0.0254
Echinococcus multilocularis zinc finger protein Ran binding 0.0251 0.1152 0.1152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0292 0.0785
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0269 0.0723
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0008 0.0021
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0093 0.0384 0.3269
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0025 0.0034
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.0282 0.0282
Echinococcus multilocularis microtubule associated protein 2 0.1496 0.7199 0.7199
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0705 0.3357 1
Echinococcus granulosus survival motor neuron protein 1 0.0262 0.1204 0.1204
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0251 0.1152 0.3431
Loa Loa (eye worm) transcription factor SMAD2 0.0377 0.1764 0.5256
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.0282 0.108
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0003 0.0002
Brugia malayi intermediate filament protein 0.0029 0.0076 0.0225
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0074 0.0293 0.2464
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0956 0.4578 0.4578
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0008 0.0021
Echinococcus granulosus mixed lineage leukemia protein mll 0.002 0.0033 0.0032
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0018 0.002 0.0019
Echinococcus granulosus smad 0.0026 0.0059 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0319 0.0856
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0251 0.1152 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0021 0.0028
Trypanosoma brucei hypothetical protein, conserved 0.008 0.0322 0.2716
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0008 0.0021
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0251 0.1152 0.3382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0236 0.0635
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0055 0.0092
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.008 0.0322 0.1245
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0101 0.0272
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0186 0.0554
Onchocerca volvulus 0.0705 0.3357 0.9002
Loa Loa (eye worm) phosphatidylinositol 3 0.0093 0.0384 0.1145
Onchocerca volvulus 0.01 0.0418 0.0938
Schistosoma mansoni smad1 5 8 and 0.0026 0.0059 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0085 0.0229
Leishmania major hypothetical protein, conserved 0.0251 0.1152 1
Leishmania major hypothetical protein, conserved 0.0251 0.1152 1
Schistosoma mansoni hypothetical protein 0.0052 0.0186 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0085 0.0229
Schistosoma mansoni hypothetical protein 0.0052 0.0186 0.0258
Echinococcus multilocularis beta LACTamase domain containing family member 0.008 0.0322 0.0321
Onchocerca volvulus Huntingtin homolog 0.0141 0.0619 0.1491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0384 0.1033
Echinococcus multilocularis SWI:SNF matrix associated 0.0705 0.3357 0.3357
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0186 0.0553
Mycobacterium tuberculosis Probable hydrolase 0.008 0.0322 0.1245
Brugia malayi hypothetical protein 0.0073 0.0288 0.0857
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0021 0.0021
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0288 0.04
Loa Loa (eye worm) hypothetical protein 0.008 0.0322 0.0958
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0093 0.0384 0.3269
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0021 0.0028
Plasmodium vivax SET domain protein, putative 0.01 0.0418 0.1179
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0093 0.0384 0.0384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0269 0.0723
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0025 0.0114
Leishmania major hypothetical protein, conserved 0.008 0.0322 0.2716
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0251 0.1152 0.3431
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0251 0.1152 1
Echinococcus multilocularis zinc finger protein 0.0024 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0292 0.0785
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.001 0.0029
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0033 0.0367
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0008
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0685 0.3262 0.9718
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0116 0.0116
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0025 0.0025
Leishmania major hypothetical protein, conserved 0.0251 0.1152 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0292 0.0785
Chlamydia trachomatis DNA topoisomerase I 0.0705 0.3357 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0288 0.0288
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0052 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0251 0.1152 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0177 0.0476
Mycobacterium tuberculosis Probable lipase LipD 0.008 0.0322 0.1245
Echinococcus granulosus microtubule associated protein 2 0.1496 0.7199 0.7199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0085 0.0229
Brugia malayi hypothetical protein 0.0262 0.1204 0.3587
Plasmodium vivax hypothetical protein, conserved 0.008 0.0322 0.089
Trypanosoma cruzi WLM domain containing protein, putative 0.0251 0.1152 1
Echinococcus multilocularis cpg binding protein 0.0073 0.0288 0.0287
Loa Loa (eye worm) hypothetical protein 0.008 0.0322 0.0958
Echinococcus granulosus SWI:SNF matrix associated 0.0705 0.3357 0.3357
Echinococcus granulosus ring and YY1 binding protein 0.0251 0.1152 0.1152
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0076 0.0225
Onchocerca volvulus 0.008 0.0322 0.0674
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.0078
Onchocerca volvulus 0.008 0.0322 0.0674
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0018 0.002 0.0067
Schistosoma mansoni ap endonuclease 0.002 0.0033 0.0045
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0033 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0322 0.0864
Echinococcus multilocularis mixed lineage leukemia protein mll 0.002 0.0033 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0269 0.0723
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0025 0.0073
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0129 0.0179
Brugia malayi beta-lactamase 0.008 0.0322 0.0957
Loa Loa (eye worm) brahma associated protein 0.0705 0.3357 1
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0705 0.3357 0.3357
Onchocerca volvulus 0.008 0.0322 0.0674
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0251 0.1152 0.2952
Schistosoma mansoni ap endonuclease 0.002 0.0033 0.0045
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0705 0.3357 1
Plasmodium vivax hypothetical protein, conserved 0.0705 0.3357 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0031 0.0085 0.0645
Mycobacterium tuberculosis Probable lipase LipE 0.008 0.0322 0.1245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0201 0.0539
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.01 0.0418 0.1193
Brugia malayi hypothetical protein 0.0025 0.0055 0.0164
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0093 0.0384 0.1145
Loa Loa (eye worm) hypothetical protein 0.0048 0.0169 0.0503
Mycobacterium ulcerans beta-lactamase 0.008 0.0322 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0018 0.002 0.0019
Brugia malayi Calcitonin receptor-like protein seb-1 0.0164 0.073 0.2173
Loa Loa (eye worm) hypothetical protein 0.008 0.0322 0.0958
Onchocerca volvulus 0.0501 0.2365 0.6281
Brugia malayi MH1 domain containing protein 0.0014 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0251 0.1152 0.3431
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0093 0.0384 0.3269
Mycobacterium tuberculosis Conserved protein 0.008 0.0322 0.1245
Echinococcus granulosus serine protein kinase ATM 0.0018 0.002 0.0019
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0025 0.0016
Echinococcus multilocularis dnaJ subfamily B 0.0953 0.4563 0.4563
Mycobacterium leprae Probable lipase LipE 0.008 0.0322 0.5
Echinococcus multilocularis smad 0.0026 0.0059 0.0059
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0322 0.0446
Schistosoma mansoni cpg binding protein 0.0073 0.0288 0.0399
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0059 0.0176
Schistosoma mansoni zinc finger protein 0.0024 0.0052 0.0072
Loa Loa (eye worm) hypothetical protein 0.008 0.0322 0.0958
Loa Loa (eye worm) hypothetical protein 0.004 0.0129 0.0383
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0085 0.0254
Schistosoma mansoni zinc finger protein 0.0016 0.0012 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0322 0.0864
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0705 0.3357 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0033 0.0032
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0093 0.0384 0.3269
Loa Loa (eye worm) CXXC zinc finger family protein 0.0067 0.0259 0.0773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0203 0.0546
Echinococcus multilocularis Smad4 0.0026 0.0059 0.0059
Loa Loa (eye worm) beta-lactamase 0.008 0.0322 0.0958
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0008 0.0021
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0322 0.0864
Schistosoma mansoni zinc finger protein 0.0251 0.1152 0.16
Loa Loa (eye worm) hypothetical protein 0.008 0.0322 0.0958
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0059 0.0082
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0033 0.0185
Echinococcus granulosus neuropeptide receptor A26 0.0545 0.2583 0.2582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0201 0.0539
Schistosoma mansoni cpg binding protein 0.0073 0.0288 0.0399
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0251 0.1152 1
Echinococcus granulosus neuropeptide s receptor 0.0545 0.2583 0.2582
Schistosoma mansoni hypothetical protein 0.0022 0.0039 0.0054
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0021 0.0021
Schistosoma mansoni TRABID protein (C64 family) 0.0251 0.1152 0.16
Onchocerca volvulus 0.0251 0.1152 0.2952
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0164 0.073 0.2173
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0113 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0177 0.0476
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0025 0.0114
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0025 0.0025
Entamoeba histolytica hypothetical protein 0.0073 0.0288 0.7354
Loa Loa (eye worm) MH2 domain-containing protein 0.0377 0.1764 0.5256
Brugia malayi beta-lactamase family protein 0.008 0.0322 0.0957
Loa Loa (eye worm) histone methyltransferase 0.0024 0.0052 0.0156
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0025 0.0025
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0093 0.0384 1
Entamoeba histolytica hypothetical protein 0.0073 0.0288 0.7354
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.008 0.0322 0.1245
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0113 0.0336
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0008 0.0021
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0705 0.3357 1
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0322 0.0864
Brugia malayi brahma associated protein 60 kDa 0.0705 0.3357 1
Schistosoma mansoni intermediate filament proteins 0.0029 0.0076 0.0105
Schistosoma mansoni hypothetical protein 0.0112 0.0478 0.0664
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0008 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0292 0.0785
Schistosoma mansoni cpg binding protein 0.0067 0.0259 0.036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0078
Schistosoma mansoni Smad4 0.0026 0.0059 0.0082
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0251 0.1152 1
Echinococcus multilocularis geminin 0.02 0.0905 0.0905
Mycobacterium tuberculosis Probable conserved lipoprotein 0.008 0.0322 0.1245
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.0282 0.0282
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.002 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0203 0.0546
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0322 0.2716
Echinococcus multilocularis SWI:SNF matrix associated 0.0705 0.3357 0.3357
Brugia malayi MH1 domain containing protein 0.0014 0.0003 0.0009
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0067 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.002 0.0052
Loa Loa (eye worm) hypothetical protein 0.0262 0.1204 0.3588
Loa Loa (eye worm) hypothetical protein 0.0074 0.0292 0.0871
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0076 0.0225
Toxoplasma gondii ABC1 family protein 0.008 0.0322 0.0905
Schistosoma mansoni hypothetical protein 0.0073 0.0288 0.04
Brugia malayi Pre-SET motif family protein 0.0685 0.3262 0.9718
Trypanosoma brucei hypothetical protein, conserved 0.0251 0.1152 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0322 0.0958
Echinococcus multilocularis neuropeptide receptor A26 0.0545 0.2583 0.2582
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0322 0.0864
Brugia malayi isocitrate dehydrogenase 0.0019 0.0025 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0269 0.0723
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0033 0.0033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0008 0.0021
Brugia malayi Bromodomain containing protein 0.004 0.0128 0.0381
Loa Loa (eye worm) hypothetical protein 0.0251 0.1152 0.3431
Brugia malayi Pre-SET motif family protein 0.01 0.0418 0.1244
Echinococcus granulosus histone lysine methyltransferase setb 0.0117 0.0504 0.0504
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0016
Onchocerca volvulus 0.078 0.3721 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0031 0.0085 0.0085
Schistosoma mansoni microtubule-associated protein tau 0.1496 0.7199 1
Mycobacterium ulcerans hypothetical protein 0.008 0.0322 1
Schistosoma mansoni hypothetical protein 0.0251 0.1152 0.16
Loa Loa (eye worm) hypothetical protein 0.0052 0.0186 0.0554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0292 0.0785
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0085 0.0645
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0008 0.0021
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.001 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0177 0.0475
Mycobacterium leprae conserved hypothetical protein 0.008 0.0322 0.5
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0141 0.0619 0.1845
Loa Loa (eye worm) hypothetical protein 0.0303 0.1408 0.4193
Brugia malayi MH2 domain containing protein 0.0026 0.0059 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0008 0.0021
Chlamydia trachomatis SWIB complex protein 0.0705 0.3357 0.5
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0031 0.0085 0.0645
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0033 0.0088
Loa Loa (eye worm) hypothetical protein 0.0251 0.1152 0.3431
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0031 0.0085 0.0645
Loa Loa (eye worm) Smad1 0.0026 0.0059 0.0176
Mycobacterium ulcerans lipase LipD 0.008 0.0322 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0186 0.0186
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0039 0.0116
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.002 0.0058
Schistosoma mansoni hypothetical protein 0.0053 0.0193 0.0268
Loa Loa (eye worm) nuclear factor I 0.0014 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0032 0.0089 0.0266
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0018 0.002 0.0067
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0044 0.0147 0.1188
Brugia malayi YY1-associated factor 2 0.0251 0.1152 0.3431
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0059 0.0059
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0322 0.0446
Loa Loa (eye worm) hypothetical protein 0.0501 0.2365 0.7046
Schistosoma mansoni smad1 5 8 and 0.0026 0.0059 0.0082
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0251 0.1152 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0186 0.0186
Brugia malayi brahma associated protein 60 kDa 0.0705 0.3357 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0478 0.1424
Echinococcus multilocularis lamin dm0 0.0029 0.0076 0.0075
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0093 0.0384 1
Giardia lamblia GTOR 0.0093 0.0384 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0117 0.0504 0.0504
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0282 0.0392
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0024 0.0071
Loa Loa (eye worm) hypothetical protein 0.0117 0.0504 0.1502
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0255 0.0255
Trichomonas vaginalis esterase, putative 0.008 0.0322 0.0864
Onchocerca volvulus Huntingtin homolog 0.0141 0.0619 0.1491
Echinococcus multilocularis tumor protein p63 0.2073 1 1
Schistosoma mansoni hypothetical protein 0.02 0.0905 0.1257
Leishmania major hypothetical protein, conserved 0.0251 0.1152 1
Echinococcus multilocularis GPCR, family 2 0.0052 0.0186 0.0186
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0251 0.1152 0.3431
Mycobacterium tuberculosis Conserved protein 0.008 0.0322 0.1245
Brugia malayi MH2 domain containing protein 0.0026 0.0059 0.0175
Brugia malayi hypothetical protein 0.0141 0.0619 0.1844
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0039 0.0121 0.0961
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0018 0.002 0.0027
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0033 0.0045
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0033 0.0088
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0251 0.1152 0.3431
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0164 0.073 0.2173
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0093 0.0384 0.0384
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0033 0.0098
Echinococcus multilocularis neuropeptide s receptor 0.0545 0.2583 0.2582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0203 0.0546
Mycobacterium ulcerans esterase/lipase LipP 0.008 0.0322 1
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.0282 0.0787
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0055 0.0382
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0033 0.5
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0003 0.0002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0033 0.0185
Brugia malayi PHD-finger family protein 0.003 0.0079 0.0235
Schistosoma mansoni lamin 0.0029 0.0076 0.0105
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0008 0.0021
Toxoplasma gondii ran binding protein 0.0251 0.1152 0.3393
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.008 0.0322 0.0958
Brugia malayi hypothetical protein 0.0501 0.2365 0.7046
Trichomonas vaginalis helicase, putative 0.0015 0.0008 0.0021
Schistosoma mansoni hypothetical protein 0.0705 0.3357 0.4663
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.0282 0.2371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.002 0.0052
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0705 0.3357 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0288 0.0288
Leishmania major hypothetical protein, conserved 0.0025 0.0055 0.0382

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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