Detailed information for compound 728530

Basic information

Technical information
  • TDR Targets ID: 728530
  • Name: N-(4-morpholin-4-ylsulfonylphenyl)-2-(4-oxoqu inazolin-3-yl)acetamide
  • MW: 428.462 | Formula: C20H20N4O5S
  • H donors: 1 H acceptors: 4 LogP: 0.57 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1cnc2c(c1=O)cccc2)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1
  • InChi: 1S/C20H20N4O5S/c25-19(13-23-14-21-18-4-2-1-3-17(18)20(23)26)22-15-5-7-16(8-6-15)30(27,28)24-9-11-29-12-10-24/h1-8,14H,9-13H2,(H,22,25)
  • InChiKey: JTIIHZSIMVIDIF-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(4-morpholinosulfonylphenyl)-2-(4-oxoquinazolin-3-yl)acetamide
  • N-(4-morpholinosulfonylphenyl)-2-(4-oxo-3-quinazolinyl)acetamide
  • 2-(4-ketoquinazolin-3-yl)-N-(4-morpholinosulfonylphenyl)acetamide
  • N-(4-morpholin-4-ylsulfonylphenyl)-2-(4-oxoquinazolin-3-yl)ethanamide
  • CBKinase1_021958
  • MLS000621721
  • N-[4-(4-morpholinylsulfonyl)phenyl]-2-(4-oxo-3(4H)-quinazolinyl)acetamide
  • SMR000300532
  • ZINC02867167
  • CBKinase1_009558
  • STK197212

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Equus caballus Ferritin light chain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni bromodomain containing protein 0.0014 0.0021 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.008 0.054
Loa Loa (eye worm) hypothetical protein 0.0053 0.0339 0.059
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Trichomonas vaginalis chromobox protein, putative 0.0097 0.0696 0.1527
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0123 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Entamoeba histolytica hypothetical protein 0.0074 0.0508 0.1116
Onchocerca volvulus 0.0026 0.0123 0.000000055905
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0213 0.0304
Leishmania major phosphatidylinositol 3-related kinase, putative 0.002 0.0069 0.0152
Loa Loa (eye worm) beta-lactamase 0.0194 0.1488 0.2587
Leishmania major phosphatidylinositol 3-kinase, putative 0.002 0.0069 0.0152
Leishmania major phosphatidylinositol kinase related protein, putative 0.002 0.0069 0.0152
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.011 0.0187
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0399 0.0875
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0081 0.0027
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0285 0.0484
Echinococcus multilocularis dna polymerase kappa 0.0021 0.008 0.0115
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0253 0.1963 0.2797
Echinococcus multilocularis zinc finger protein 0.0063 0.042 0.0598
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.008 0.054
Brugia malayi RNA recognition motif domain containing protein 0.0286 0.2235 0.3885
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0024 0.0041
Trichomonas vaginalis penicillin-binding protein, putative 0.0194 0.1488 0.3266
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.0567 0.0808
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0361 0.2844 0.4942
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0026 0.0123 0.0269
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.002 0.0069 0.0117
Mycobacterium ulcerans lipase LipD 0.0194 0.1488 0.6741
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0366 0.0621
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0213 0.1015
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0024 0.0053
Echinococcus granulosus chromobox protein 1 0.0161 0.1214 0.2059
Brugia malayi beta-lactamase 0.0194 0.1488 0.2587
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.0567 0.0961
Entamoeba histolytica hypothetical protein 0.0074 0.0508 0.1116
Loa Loa (eye worm) hypothetical protein 0.0062 0.0412 0.0715
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0027 0.0129 0.0867
Trichomonas vaginalis esterase, putative 0.0194 0.1488 0.3266
Mycobacterium tuberculosis Probable lipase LipD 0.0194 0.1488 0.142
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0069 0.0002
Echinococcus granulosus Chromobox protein 3 0.0026 0.0123 0.0208
Loa Loa (eye worm) hypothetical protein 0.0515 0.4093 0.7113
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0024 0.0041
Loa Loa (eye worm) transcription factor SMAD2 0.0363 0.2862 0.4973
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.002 0.0069 0.0117
Echinococcus multilocularis serine protein kinase ATM 0.0027 0.0129 0.0184
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0081 0.0179
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0347 0.0604
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0213 0.0468
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0081 0.0142
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0012 0.001 0.0021
Mycobacterium leprae Probable lipase LipE 0.0194 0.1488 1
Schistosoma mansoni zinc finger protein 0.0049 0.0308 0.0523
Brugia malayi MH1 domain containing protein 0.0014 0.002 0.0035
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.033 0.2214
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Trichomonas vaginalis chromobox protein, putative 0.0161 0.1214 0.2663
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0024 0.0041
Onchocerca volvulus Heterochromatin protein 1 homolog 0.009 0.064 0.1433
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0179 0.0392
Schistosoma mansoni hypothetical protein 0.0163 0.1233 0.2091
Brugia malayi RNA binding protein 0.0286 0.2235 0.3885
Brugia malayi hypothetical protein 0.0719 0.5754 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0069 0.012
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0101 0.0222
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0024 0.0042
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0179 0.031
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0123 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0123 0.0269
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.002 0.0069 0.0099
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0032 0.0172 0.0292
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0213 0.0468
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.008 0.014
Onchocerca volvulus 0.0194 0.1488 0.378
Loa Loa (eye worm) CHromoDomain protein family member 0.0032 0.0172 0.03
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0284 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.001 0.0021
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.033 0.0723
Brugia malayi PHD-finger family protein 0.0033 0.0179 0.031
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Echinococcus multilocularis tumor protein p63 0.0384 0.3033 0.4321
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.008 0.0079
Brugia malayi Smad1 0.0025 0.011 0.0191
Brugia malayi glutaminase DH11.1 0.0278 0.2169 0.377
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0263 0.0577
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0391 0.0859
Brugia malayi Pre-SET motif family protein 0.0059 0.0391 0.068
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0567 0.1244
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.008 0.0136
Loa Loa (eye worm) hypothetical protein 0.0194 0.1488 0.2587
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0466 0.0809
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0374 0.0634
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0179 0.0303
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0024 0.0034
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.033 0.1834
Toxoplasma gondii hypothetical protein 0.0028 0.0136 0.0298
Loa Loa (eye worm) hypothetical protein 0.0122 0.0899 0.1562
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.034 0.0262
Entamoeba histolytica hypothetical protein 0.0074 0.0508 0.1116
Trichomonas vaginalis chromobox protein, putative 0.0026 0.0123 0.0269
Echinococcus granulosus methyl CpG binding domain protein 2 0.0055 0.0354 0.06
Echinococcus multilocularis lamin 0.0054 0.0347 0.0495
Loa Loa (eye worm) hypothetical protein 0.0163 0.1233 0.2142
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0123 0.0269
Schistosoma mansoni tar DNA-binding protein 0.0286 0.2235 0.3791
Onchocerca volvulus Huntingtin homolog 0.0122 0.0899 0.2147
Schistosoma mansoni ap endonuclease 0.0021 0.0081 0.0138
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0081 0.0179
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0399 0.0677
Schistosoma mansoni chromobox protein 0.0161 0.1214 0.2059
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.039 0.0856
Schistosoma mansoni hypothetical protein 0.0737 0.5896 1
Leishmania major DNA polymerase kappa, putative 0.0021 0.008 0.0176
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0213 0.0304
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.008 0.054
Schistosoma mansoni jumonji domain containing protein 0.0086 0.061 0.1035
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0567 1
Brugia malayi Bromodomain containing protein 0.0241 0.1866 0.3243
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0024 0.0053
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0026 0.0123 0.0213
Loa Loa (eye worm) glutaminase 2 0.0278 0.2169 0.377
Trichomonas vaginalis chromobox protein, putative 0.0097 0.0696 0.1527
Loa Loa (eye worm) hypothetical protein 0.0059 0.039 0.0678
Loa Loa (eye worm) hypothetical protein 0.0194 0.1488 0.2587
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0081 0.0179
Toxoplasma gondii ABC1 family protein 0.0194 0.1488 0.3266
Brugia malayi hypothetical protein 0.0026 0.0123 0.0213
Brugia malayi PHD-finger family protein 0.008 0.0559 0.0971
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0144 0.025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.0036
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0213 0.0304
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0101 0.0144
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.008 0.0136
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.033 0.0469
Brugia malayi M-phase phosphoprotein, mpp8 0.0026 0.0123 0.0213
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.039 0.2621
Schistosoma mansoni hypothetical protein 0.0163 0.1233 0.2091
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.002 0.0069 0.0465
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0299 0.0656
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0567 0.5
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0213 0.0371
Trichomonas vaginalis D-aminoacylase, putative 0.0194 0.1488 0.3266
Brugia malayi SET domain containing protein 0.0028 0.014 0.0244
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.033 0.0723
Brugia malayi CHD4 protein 0.0032 0.0172 0.03
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0081 0.0179
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.002 0.0069 0.0152
Plasmodium falciparum macrophage migration inhibitory factor 0.0572 0.4558 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0515 0.113
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0014 0.0024 0.0042
Schistosoma mansoni chromobox protein 0.0026 0.0123 0.0208
Echinococcus multilocularis dna polymerase eta 0.0021 0.008 0.0115
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.034 0.0262
Echinococcus multilocularis survival motor neuron protein 1 0.0719 0.5754 0.8198
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.008 0.014
Brugia malayi Importin beta-1 subunit 0.0059 0.039 0.0678
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0194 0.1488 0.142
Trypanosoma cruzi ISWI complex protein 0.0049 0.0308 0.1684
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0024 0.0041
Trichomonas vaginalis chromobox protein, putative 0.0161 0.1214 0.2663
Leishmania major hypothetical protein, conserved 0.0194 0.1488 0.3266
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0115 0.0847 0.1206
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0136 0.1116
Schistosoma mansoni hypothetical protein 0.0049 0.0308 0.0523
Echinococcus granulosus histone lysine methyltransferase setb 0.0114 0.0836 0.1418
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0123 0.0269
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0572 0.4558 0.7921
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0515 0.346
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.008 0.054
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0101 0.0679
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0263 0.0457
Entamoeba histolytica hypothetical protein 0.0026 0.0123 0.0269
Schistosoma mansoni survival motor neuron protein 0.0147 0.1101 0.1868
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0081 0.0087
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0194 0.1488 0.2524
Loa Loa (eye worm) hypothetical protein 0.0054 0.0347 0.0604
Echinococcus granulosus snurportin 1 0.0632 0.5045 0.8556
Brugia malayi RNA, U transporter 1 0.0168 0.1277 0.2219
Brugia malayi hypothetical protein 0.0122 0.0899 0.1562
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0123 0.0269
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0347 0.0604
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0024 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0572 0.4558 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.008 0.054
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0026 0.0123 0.0208
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.008 0.0115
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0285 0.2224 0.3866
Entamoeba histolytica hypothetical protein 0.0026 0.0123 0.0269
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0024 0.0041
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0286 0.2235 0.3885
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.008 0.0176
Mycobacterium tuberculosis Probable lipase LipE 0.0194 0.1488 0.142
Schistosoma mansoni tar DNA-binding protein 0.0286 0.2235 0.3791
Echinococcus granulosus GPCR family 2 0.0163 0.1233 0.2091
Echinococcus granulosus Smad4 0.0025 0.011 0.0187
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0179 0.0303
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0399 0.1525
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0024 0.0041
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0024 0.0041
Mycobacterium tuberculosis Probable hydrolase 0.0194 0.1488 0.142
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0213 0.0362
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0046 0.0065
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0123 0.0269
Giardia lamblia DINP protein human, muc B family 0.0021 0.008 0.0025
Mycobacterium ulcerans hypothetical protein 0.0194 0.1488 0.6741
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0081 0.0547
Schistosoma mansoni tar DNA-binding protein 0.0286 0.2235 0.3791
Trypanosoma cruzi ISWI complex protein 0.0049 0.0308 0.1684
Brugia malayi MH1 domain containing protein 0.0025 0.011 0.0191
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0515 0.3141
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0086 0.0605 0.1026
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0098 0.0204
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0399 0.1525
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0572 0.4558 1
Brugia malayi MH2 domain containing protein 0.0025 0.011 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0299 0.0656
Schistosoma mansoni hypothetical protein 0.0163 0.1233 0.2091
Loa Loa (eye worm) hypothetical protein 0.0194 0.1488 0.2587
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0198 0.1521 0.387
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0024 0.0041
Echinococcus granulosus inositol monophosphatase 1 0.0075 0.0515 0.0873
Schistosoma mansoni hypothetical protein 0.0163 0.1233 0.2091
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0082
Loa Loa (eye worm) hypothetical protein 0.0081 0.0567 0.0985
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0101 0.0222
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0062 0.0412 0.0715
Onchocerca volvulus 0.0194 0.1488 0.378
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0147 0.1101 0.1914
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0163 0.1233 0.1756
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.033 0.0723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0253 0.1963 0.333
Echinococcus multilocularis chromobox protein 1 0.0161 0.1214 0.1729
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0101 0.0176
Loa Loa (eye worm) hypothetical protein 0.0361 0.2844 0.4942
Onchocerca volvulus 0.0086 0.0605 0.1335
Loa Loa (eye worm) hypothetical protein 0.0227 0.1754 0.3049
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0399 0.0875
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0129 0.0422
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0081 0.0142
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0399 0.0321
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Schistosoma mansoni hypothetical protein 0.0066 0.0447 0.0759
Brugia malayi latrophilin 2 splice variant baaae 0.0352 0.2769 0.4812
Loa Loa (eye worm) hypothetical protein 0.0021 0.008 0.014
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0399 0.0677
Loa Loa (eye worm) PHD-finger family protein 0.0066 0.0447 0.0777
Schistosoma mansoni tar DNA-binding protein 0.0286 0.2235 0.3791
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0123 0.0269
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.002 0.0069 0.0465
Trichomonas vaginalis ran, putative 0.0044 0.0263 0.0577
Giardia lamblia PHD finger protein 15 0.0033 0.0179 0.0244
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0081 0.0001
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0012 0.001 0.0065
Leishmania major hypothetical protein, conserved 0.0049 0.0308 0.0676
Schistosoma mansoni hypothetical protein 0.0737 0.5896 1
Echinococcus multilocularis Chromo domain 0.0026 0.0123 0.0175
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0213
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0399 0.0677
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0123 0.0269
Echinococcus multilocularis tar DNA binding protein 0.0286 0.2235 0.3184
Onchocerca volvulus 0.0471 0.3737 1
Brugia malayi Bromodomain containing protein 0.0123 0.0908 0.1578
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0035
Loa Loa (eye worm) hypothetical protein 0.0137 0.1022 0.1776
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0024 0.0034
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0196
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0026 0.0123 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0129 0.0283
Trichomonas vaginalis chaperonin, putative 0.0024 0.0101 0.0222
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0101 0.0172
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.002 0.0069 0.0465
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.008 0.054
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.033 0.0469
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0081 0.0179
Entamoeba histolytica Ran family GTPase 0.0044 0.0263 0.0577
Mycobacterium leprae conserved hypothetical protein 0.0194 0.1488 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0213 0.0362
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0024 0.0041
Trypanosoma brucei hypothetical protein, conserved 0.0194 0.1488 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0123 0.0269
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0213 0.0321
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Onchocerca volvulus 0.0062 0.0412 0.08
Echinococcus multilocularis smad 0.0025 0.011 0.0157
Brugia malayi intermediate filament protein 0.0054 0.0347 0.0604
Toxoplasma gondii target of rapamycin (TOR), putative 0.002 0.0069 0.0152
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.008 0.0079
Echinococcus granulosus lamin dm0 0.0054 0.0347 0.0589
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0572 0.4558 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0097 0.0696 0.1587
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.002 0.0069 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.008 0.054
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0123 0.0269
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0015 0.0025
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0114 0.0836 0.1418
Echinococcus granulosus serine protein kinase ATM 0.0027 0.0129 0.0219
Onchocerca volvulus 0.0054 0.0347 0.0622
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0452 0.0374
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.008 0.0079
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0194 0.1488 0.6741
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0075 0.0515 0.8932
Mycobacterium tuberculosis Conserved protein 0.0194 0.1488 0.142
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0253 0.1963 0.3412
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0014 0.0024 0.0034
Brugia malayi Latrophilin receptor protein 2 0.0163 0.1233 0.2142
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.033 0.0723
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.033 0.0559
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.002 0.0069 0.0099
Loa Loa (eye worm) hypothetical protein 0.0194 0.1488 0.2587
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0123 0.0269
Schistosoma mansoni inositol monophosphatase 0.0075 0.0515 0.0873
Echinococcus multilocularis neuropeptide receptor A26 0.0473 0.3753 0.5347
Echinococcus granulosus neuropeptide receptor A26 0.0473 0.3753 0.6366
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0567 0.1244
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0253 0.1963 0.333
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0109 0.0792 0.1128
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0024 0.0041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0123 0.0269
Echinococcus granulosus beta LACTamase domain containing family member 0.0194 0.1488 0.2524
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0194 0.1488 0.2524
Schistosoma mansoni smad1 5 8 and 0.0025 0.011 0.0187
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0101 0.0172
Trichomonas vaginalis glutaminase, putative 0.0278 0.2169 0.476
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0391 0.0558
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0347 0.0604
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0014 0.0024 0.0042
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0705 0.5635 0.9793
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0026 0.0123 0.0269
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.008 0.054
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0567 0.1244
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0062 0.0412 0.0715
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0062 0.0412 0.0715
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0026 0.0123 0.0175
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.0567 0.0961
Echinococcus granulosus lamin 0.0054 0.0347 0.0589
Loa Loa (eye worm) glutaminase 0.0278 0.2169 0.377
Trichomonas vaginalis chromobox protein, putative 0.0026 0.0123 0.0269
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.008 0.0079
Entamoeba histolytica hypothetical protein 0.0074 0.0508 0.1116
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0024 0.0042
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0213 0.0362
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0213 0.0468
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0024 0.0041
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0046 0.0078
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.011 0.0187
Brugia malayi jmjC domain containing protein 0.0109 0.0792 0.1376
Loa Loa (eye worm) nuclear factor I 0.0014 0.002 0.0035
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.0567 1
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0062 0.0412 0.0715
Echinococcus granulosus neuropeptide s receptor 0.0473 0.3753 0.6366
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0017
Schistosoma mansoni hypothetical protein 0.0147 0.1101 0.1868
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0572 0.4558 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0123 0.0269
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0081 0.0179
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0263 0.1366
Schistosoma mansoni chromobox protein 0.0026 0.0123 0.0208
Echinococcus multilocularis Chromobox protein 3 0.0026 0.0123 0.0175
Echinococcus granulosus chromobox protein 1 0.0161 0.1214 0.2059
Echinococcus multilocularis GPCR, family 2 0.0163 0.1233 0.1756
Schistosoma mansoni bromodomain containing protein 0.0203 0.156 0.2646
Echinococcus granulosus tar DNA binding protein 0.0286 0.2235 0.3791
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0081 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0253 0.1963 0.2797
Schistosoma mansoni ran 0.0044 0.0263 0.0446
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.008 0.054
Echinococcus granulosus geminin 0.0737 0.5896 1
Onchocerca volvulus 0.0056 0.0366 0.0674
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0263 0.0577
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0114 0.0836 0.1418
Plasmodium vivax SET domain protein, putative 0.0059 0.0391 0.0859
Schistosoma mansoni hypothetical protein 0.0026 0.0123 0.0208
Mycobacterium ulcerans glutaminase 0.0278 0.2169 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Brugia malayi Bromodomain containing protein 0.0041 0.024 0.0418
Echinococcus multilocularis lamin dm0 0.0054 0.0347 0.0495
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.011 0.0191
Onchocerca volvulus 0.0147 0.1101 0.2708
Trypanosoma brucei unspecified product 0.0015 0.0027 0.0183
Loa Loa (eye worm) inositol-1 0.0075 0.0515 0.0895
Mycobacterium ulcerans beta-lactamase 0.0194 0.1488 0.6741
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0399 0.0568
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0026 0.0123 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0427 0.0937
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0027 0.0183
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0072 0.0497 0.0708
Loa Loa (eye worm) Smad1 0.0025 0.011 0.0191
Loa Loa (eye worm) RNA binding protein 0.0286 0.2235 0.3885
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0508 0.0724
Loa Loa (eye worm) hypothetical protein 0.0033 0.0179 0.031
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0508 0.0862
Mycobacterium ulcerans esterase/lipase LipP 0.0194 0.1488 0.6741
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0075 0.0515 0.113
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0115 0.0847 0.1436
Echinococcus granulosus tumor protein p63 0.0384 0.3033 0.5145
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0101 0.0071
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0101 0.0176
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.011 0.0157
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0012 0.0004 0.0026
Mycobacterium tuberculosis Conserved protein 0.0194 0.1488 0.142
Leishmania major GTP-binding protein, putative 0.0044 0.0263 0.0577
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.033 0.1834
Brugia malayi beta-lactamase family protein 0.0194 0.1488 0.2587
Brugia malayi Pre-SET motif family protein 0.0414 0.3272 0.5686
Schistosoma mansoni ran 0.0044 0.0263 0.0446
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0024 0.0041
Echinococcus granulosus zinc finger protein 0.0063 0.042 0.0712
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0032 0.0172 0.0292
Brugia malayi Associated with TFs and helicases family protein 0.0026 0.0123 0.0213
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0114 0.0836 0.1191
Schistosoma mansoni hypothetical protein 0.0632 0.5045 0.8556
Schistosoma mansoni lamin 0.0054 0.0347 0.0589
Onchocerca volvulus 0.0071 0.0482 0.0996
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0567 0.1244
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.033 0.0723
Plasmodium vivax hypothetical protein, conserved 0.0194 0.1488 0.3266
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0027 0.0183
Loa Loa (eye worm) hypothetical protein 0.0198 0.1521 0.2643
Trichomonas vaginalis penicillin-binding protein, putative 0.0194 0.1488 0.3266
Loa Loa (eye worm) MH2 domain-containing protein 0.0363 0.2862 0.4973
Brugia malayi Calcitonin receptor-like protein seb-1 0.0515 0.4093 0.7113
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0024 0.0034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0253 0.1963 0.333
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0567 0.5
Leishmania major macrophage migration inhibitory factor-like protein 0.0572 0.4558 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0163 0.1233 0.2142
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0263 0.0457
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0163 0.1233 0.2142
Echinococcus granulosus dna polymerase eta 0.0021 0.008 0.0136
Brugia malayi Inositol-1 0.0075 0.0515 0.0895
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0042
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0299 0.0656
Echinococcus multilocularis chromobox protein 2 0.0026 0.0123 0.0175
Giardia lamblia Macrophage migration inhibitory factor 0.0572 0.4558 1
Schistosoma mansoni smad1 5 8 and 0.0025 0.011 0.0187
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0179 0.0254
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0163 0.1233 0.1756
Trichomonas vaginalis hypothetical protein 0.0026 0.0123 0.0269
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.034 0.1512
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0069 0.012
Loa Loa (eye worm) hypothetical protein 0.0123 0.091 0.1582
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0194 0.1488 0.2587
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0014 0.0024 0.0034
Echinococcus multilocularis chromobox protein 1 0.0161 0.1214 0.1729
Echinococcus granulosus chromobox protein 2 0.0026 0.0123 0.0208
Plasmodium falciparum importin beta, putative 0.0059 0.039 0.0856
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0014 0.0024 0.0034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0253 0.1963 0.333
Plasmodium vivax importin-beta 2, putative 0.0059 0.039 0.0856
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0235 0.0335
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.033 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Loa Loa (eye worm) hypothetical protein 0.0056 0.0366 0.0637
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0263 0.0432
Echinococcus granulosus importin subunit beta 1 0.0059 0.039 0.0662
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0515 0.113
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0123 0.0269
Trypanosoma cruzi hypothetical protein, conserved 0.0194 0.1488 1
Trypanosoma brucei unspecified product 0.0021 0.008 0.054
Trichomonas vaginalis D-aminoacylase, putative 0.0194 0.1488 0.3266
Schistosoma mansoni glutaminase 0.0278 0.2169 0.3679
Schistosoma mansoni zinc finger protein 0.0063 0.042 0.0712
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0026 0.0123 0.0269
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0192 0.1467 0.209
Echinococcus multilocularis snurportin 1 0.0632 0.5045 0.7187
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0285 0.2224 0.3866
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.008 0.0079
Trichomonas vaginalis D-aminoacylase, putative 0.0194 0.1488 0.3266
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0024 0.0041
Onchocerca volvulus Alhambra homolog 0.0033 0.0179 0.0155
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0123 0.0269
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.008 0.054
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0263 0.1767
Brugia malayi MAP kinase sur-1 0.0052 0.033 0.0573
Onchocerca volvulus 0.0062 0.0412 0.08
Trichomonas vaginalis conserved hypothetical protein 0.0351 0.2763 0.6063
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0213
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0024 0.0041
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0027 0.0129 0.0219
Mycobacterium tuberculosis Probable esterase LipL 0.0194 0.1488 0.142
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0213 0.1433
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0123 0.0269
Echinococcus granulosus voltage gated potassium channel 0.0014 0.0024 0.0041
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.002 0.0069 0.0117
Schistosoma mansoni intermediate filament proteins 0.0054 0.0347 0.0589
Echinococcus granulosus lysine specific demethylase 5A 0.0046 0.0285 0.0484
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.033 0.0573
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0101 0.0172
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0213 0.1015
Loa Loa (eye worm) hypothetical protein 0.0131 0.0972 0.1689
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0391 0.0664
Echinococcus granulosus survival motor neuron protein 1 0.0719 0.5754 0.9759
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0026 0.0123 0.0269
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0299 0.162
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Brugia malayi Probable ClpP-like protease 0.0081 0.0567 0.0985
Echinococcus multilocularis inositol monophosphatase 1 0.0075 0.0515 0.0734
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0213 0.0362
Loa Loa (eye worm) bromodomain containing protein 0.0057 0.037 0.0643
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0101 0.0222
Toxoplasma gondii FATC domain-containing protein 0.0027 0.0129 0.0283
Brugia malayi Cyclic-nucleotide gated cation channel 0.0014 0.0024 0.0042
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0121 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.034 0.0577
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0075 0.0515 0.113
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0515 0.4093 0.7113
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0032 0.0172 0.0246
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.002 0.0069 0.0117
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0123 0.0269
Brugia malayi secreted modular calcium-binding protein 1 0.0062 0.0412 0.0715
Loa Loa (eye worm) hypothetical protein 0.0062 0.0412 0.0715
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.008 0.054
Brugia malayi chromobox protein homolog 3 0.009 0.064 0.1113
Trypanosoma brucei unspecified product 0.0015 0.0027 0.0183
Echinococcus granulosus peregrin 0.0041 0.024 0.0408
Brugia malayi Protein cec-1. 0.0026 0.0123 0.0213
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0123 0.0269
Schistosoma mansoni lamin 0.0054 0.0347 0.0589
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0014 0.0024 0.0042
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0075 0.0515 0.2081
Brugia malayi jmjC domain containing protein 0.0046 0.0285 0.0496
Trypanosoma brucei ISWI complex protein 0.0049 0.0308 0.207
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0632 0.5045 0.8767
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0123 0.0269
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0123 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0123 0.0269
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0213
Loa Loa (eye worm) hypothetical protein 0.0062 0.0412 0.0715
Loa Loa (eye worm) helicase 0.0026 0.0123 0.0213
Schistosoma mansoni smad1 5 8 and 0.0025 0.011 0.0187
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0253 0.1963 0.3412
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Brugia malayi beta-lactamase family protein 0.0194 0.1488 0.2587
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.033 0.0559
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0123 0.0269
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0213 0.0362
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.0452 0.2335
Onchocerca volvulus 0.0054 0.0347 0.0622
Loa Loa (eye worm) hypothetical protein 0.0023 0.0098 0.0171
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.033 0.1834
Loa Loa (eye worm) hypothetical protein 0.0352 0.2769 0.4812
Trichomonas vaginalis set domain proteins, putative 0.0471 0.3737 0.8198
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0101 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Loa Loa (eye worm) TAR-binding protein 0.0286 0.2235 0.3885
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0027 0.0183
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0192 0.1467 0.2488
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0123 0.0269
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0014 0.0024 0.0041
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0069 0.012
Loa Loa (eye worm) heterochromatin protein 1 0.0161 0.1214 0.2109
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0399 0.1525
Brugia malayi MH1 domain containing protein 0.0025 0.011 0.0191
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0179 0.0392
Echinococcus granulosus fetal alzheimer antigen falz 0.0072 0.0497 0.0843
Onchocerca volvulus 0.0062 0.0412 0.08
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.008 0.054
Schistosoma mansoni methyl-cpg binding protein mbd 0.0055 0.0354 0.06
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.0567 0.3187
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0875 0.7019 1
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0065 0.0112
Schistosoma mansoni Smad4 0.0025 0.011 0.0187
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0072 0.0497 0.0843
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.0129 0.0224
Schistosoma mansoni methyl-cpg binding protein mbd 0.0055 0.0354 0.06
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0263 0.0577
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.002 0.0069 0.0465
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0194 0.1488 0.142
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.011 0.0191
Leishmania major macrophage migration inhibitory factor-like protein 0.0572 0.4558 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0144 0.025
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0285 0.0484
Entamoeba histolytica hypothetical protein 0.0026 0.0123 0.0269
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.008 0.054
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0069 0.012
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0414 0.3272 0.5686
Trypanosoma brucei target of rapamycin kinase 3, putative 0.002 0.0069 0.0465
Echinococcus multilocularis musashi 0.0054 0.0347 0.0495
Entamoeba histolytica hypothetical protein 0.0027 0.0129 0.0283
Brugia malayi MH2 domain containing protein 0.0025 0.011 0.0191
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0515 0.113
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.033 0.1834
Loa Loa (eye worm) hypothetical protein 0.0062 0.0412 0.0715
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0109 0.0792 0.1343
Brugia malayi Bm-MIF-1, identical 0.0572 0.4558 0.7921
Loa Loa (eye worm) hypothetical protein 0.0114 0.0836 0.1453
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0101 0.0222
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0194 0.1488 0.142
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.008 0.054
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0081 0.0087
Echinococcus multilocularis geminin 0.0737 0.5896 0.84
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0136 0.0298
Onchocerca volvulus Huntingtin homolog 0.0122 0.0899 0.2147
Schistosoma mansoni smad 0.0025 0.011 0.0187
Onchocerca volvulus 0.0194 0.1488 0.378
Schistosoma mansoni importin beta-1 0.0059 0.039 0.0662
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.011 0.0157
Schistosoma mansoni tar DNA-binding protein 0.0286 0.2235 0.3791
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0081 0.0138
Loa Loa (eye worm) jmjC domain-containing protein 0.0046 0.0285 0.0496
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0123 0.0269
Plasmodium falciparum heterochromatin protein 1 0.0026 0.0123 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Mycobacterium tuberculosis Conserved protein 0.0194 0.1488 0.142
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0062 0.0412 0.0715
Plasmodium falciparum phd finger protein, putative 0.0033 0.0179 0.0392
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0123 0.0208
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0572 0.4558 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0163 0.1233 0.2091
Brugia malayi MH1 domain containing protein 0.0014 0.002 0.0035
Loa Loa (eye worm) hypothetical protein 0.0719 0.5754 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0213
Echinococcus multilocularis beta LACTamase domain containing family member 0.0194 0.1488 0.2121
Echinococcus granulosus Chromo domain 0.0026 0.0123 0.0208
Schistosoma mansoni hypothetical protein 0.0033 0.0179 0.0303
Onchocerca volvulus 0.0062 0.0412 0.08
Toxoplasma gondii exonuclease III APE 0.0021 0.0081 0.0179
Loa Loa (eye worm) hypothetical protein 0.0037 0.0213 0.0371
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0567 0.2329
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.002 0.0069 0.0152
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0163 0.1233 0.2091
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0213 0.0468
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.033 0.0723
Trichomonas vaginalis chromobox protein, putative 0.0026 0.0123 0.0269
Schistosoma mansoni ap endonuclease 0.0021 0.0081 0.0138
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0213
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.008 0.0176
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0055 0.0354 0.0504
Trichomonas vaginalis inositol monophosphatase, putative 0.0075 0.0515 0.113
Brugia malayi Heterochromatin protein 1 0.0161 0.1214 0.2109
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0101 0.0222
Loa Loa (eye worm) hypothetical protein 0.0071 0.0482 0.0838
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0427 0.0937
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.008 0.0176
Echinococcus granulosus dna polymerase kappa 0.0021 0.008 0.0136
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0213
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.033 0.0559
Brugia malayi hypothetical protein 0.0074 0.0508 0.0884
Schistosoma mansoni DNA polymerase eta 0.0021 0.008 0.0136
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.039 0.2621
Echinococcus multilocularis importin subunit beta 1 0.0059 0.039 0.0556
Trichomonas vaginalis Heterochromatin protein, putative 0.0026 0.0123 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0179 0.0392
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0253 0.1963 0.333
Schistosoma mansoni hypothetical protein 0.0074 0.0508 0.0862
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0263 0.0446
Echinococcus multilocularis voltage gated potassium channel 0.0014 0.0024 0.0034
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.008 0.0176
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0123 0.0269
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.008 0.0136
Schistosoma mansoni chromobox protein 0.0161 0.1214 0.2059
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0024 0.0041
Brugia malayi TAR-binding protein 0.0286 0.2235 0.3885
Brugia malayi N-terminal motif family protein 0.0198 0.1521 0.2643
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.034 0.0485
Leishmania major DNA polymerase eta, putative 0.0021 0.008 0.0176
Brugia malayi MH2 domain containing protein 0.0363 0.2862 0.4973
Echinococcus granulosus intermediate filament protein 0.0054 0.0347 0.0589
Trichomonas vaginalis conserved hypothetical protein 0.009 0.064 0.1405
Schistosoma mansoni inositol monophosphatase 0.0075 0.0515 0.0873
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0024 0.0041
Schistosoma mansoni hypothetical protein 0.0352 0.2769 0.4696
Echinococcus multilocularis peregrin 0.0041 0.024 0.0342
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0123 0.0269
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0136 0.0298
Loa Loa (eye worm) hypothetical protein 0.0194 0.1488 0.2587
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0081 0.0116
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0515 0.4093 0.7113
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0121 0.0172
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0026 0.0123 0.0269
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0213
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0567 0.2329
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0101 0.0176
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0263 0.0375
Leishmania major importin beta-1 subunit, putative 0.0048 0.0299 0.0656
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.002 0.0069 0.0152
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0213 0.0468
Loa Loa (eye worm) hypothetical protein 0.0194 0.1488 0.2587
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.008 0.014
Brugia malayi PHD-finger family protein 0.0017 0.0047 0.0082
Loa Loa (eye worm) hypothetical protein 0.0122 0.0899 0.1562
Trichomonas vaginalis conserved hypothetical protein 0.009 0.064 0.1405
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.021
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.002 0.0069 0.0152
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0284 0.0405
Entamoeba histolytica hypothetical protein 0.0048 0.0299 0.0656
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0515 0.3141
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.001 0.0021
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0101 0.0222
Trypanosoma brucei protein kinase, putative 0.0052 0.033 0.2214
Echinococcus multilocularis Smad4 0.0025 0.011 0.0157
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0508 0.0862
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0042
Trypanosoma cruzi hypothetical protein, conserved 0.0194 0.1488 1
Brugia malayi Valyl-tRNA synthetase 0.0026 0.0123 0.0213
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0194 0.1488 0.2587
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0263 0.1366
Brugia malayi follicle stimulating hormone receptor 0.0705 0.5635 0.9793
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0069 0.0152
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0014 0.0024 0.0041
Echinococcus multilocularis neuropeptide s receptor 0.0473 0.3753 0.5347
Echinococcus granulosus smad 0.0025 0.011 0.0187
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0101 0.0172
Plasmodium vivax heterochromatin protein 1, putative 0.0026 0.0123 0.0269
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.011 0.0187
Loa Loa (eye worm) hypothetical protein 0.009 0.064 0.1113
Loa Loa (eye worm) hypothetical protein 0.0057 0.0371 0.0645
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.033 0.0723

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0033 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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