Detailed information for compound 730463

Basic information

Technical information
  • TDR Targets ID: 730463
  • Name: dimethyl 5-[[2-(2-chlorophenoxy)acetyl]amino] benzene-1,3-dicarboxylate
  • MW: 377.776 | Formula: C18H16ClNO6
  • H donors: 1 H acceptors: 3 LogP: 3.13 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1cc(NC(=O)COc2ccccc2Cl)cc(c1)C(=O)OC
  • InChi: 1S/C18H16ClNO6/c1-24-17(22)11-7-12(18(23)25-2)9-13(8-11)20-16(21)10-26-15-6-4-3-5-14(15)19/h3-9H,10H2,1-2H3,(H,20,21)
  • InChiKey: DLMALBBNONSHAS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[[2-(2-chlorophenoxy)-1-oxoethyl]amino]benzene-1,3-dicarboxylic acid dimethyl ester
  • 5-[[2-(2-chlorophenoxy)acetyl]amino]benzene-1,3-dicarboxylic acid dimethyl ester
  • dimethyl 5-[2-(2-chlorophenoxy)ethanoylamino]benzene-1,3-dicarboxylate
  • STK276343
  • ZINC01075253
  • CBKinase1_022552
  • CBKinase1_010152

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0468 0.1681
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0671 0.3539 0.5838
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0129 0.0135
Loa Loa (eye worm) hypothetical protein 0.0054 0.0186 0.0556
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0095 0.041 0.0432
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.1132 0.6038 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0095 0.041 0.0432
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0149 0.0703 0.0647
Echinococcus granulosus tumor protein p63 0.1767 0.9486 1
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0044 0.0132 0.014
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0055 0.0193 0.0305
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Mycobacterium tuberculosis Probable hydrolase 0.0291 0.1477 0.1424
Schistosoma mansoni apoferritin-2 0.0045 0.0138 0.0228
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0366 0.0591
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0095 0.041 0.0432
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0129 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0366 0.0591
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.041 0.0679
Giardia lamblia DINP protein human, muc B family 0.0045 0.0137 0.0218
Trypanosoma brucei THT1 - hexose transporter, putative 0.0095 0.0412 0.0667
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.0386
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0045 0.0137 0.0076
Loa Loa (eye worm) hypothetical protein 0.0259 0.1299 0.3881
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0132 0.0102
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0106 0.0468 0.0721
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.029 0.0466
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0105 0.0466 0.0491
Trichomonas vaginalis ferritin, putative 0.0045 0.0138 0.0175
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0092 0.0395 0.1346
Brugia malayi AMP-binding enzyme family protein 0.0149 0.0703 0.1165
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.1132 0.6038 1
Echinococcus granulosus solute carrier family 22 0.0043 0.0129 0.0136
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0393 0.0415
Plasmodium falciparum acyl-CoA synthetase 0.0111 0.0499 0.0668
Onchocerca volvulus 0.0043 0.0129 0.0721
Toxoplasma gondii propionate-CoA ligase 0.0044 0.0132 0.0183
Trypanosoma brucei glucose transporter, putative 0.0095 0.0412 0.0667
Schistosoma mansoni glucose transport protein 0.0307 0.1561 0.2586
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0051 0.0152
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.0386
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0095 0.041 0.054
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0366 0.0551
Plasmodium vivax hypothetical protein, conserved 0.0291 0.1477 0.2077
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0129 0.0135
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0043 0.0129 0.0135
Mycobacterium ulcerans hypothetical protein 0.0149 0.0703 0.1059
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0094 0.0407 0.066
Echinococcus granulosus mitogen activated protein kinase 3 0.0106 0.0468 0.0494
Trichomonas vaginalis esterase, putative 0.0291 0.1477 0.6276
Leishmania major DNA polymerase eta, putative 0.0031 0.0061 0.0042
Brugia malayi Sugar transporter family protein 0.0043 0.0129 0.0214
Leishmania major DNA polymerase kappa, putative 0.0045 0.0137 0.0168
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Echinococcus granulosus lamin dm0 0.0054 0.0186 0.0196
Schistosoma mansoni lamin 0.0054 0.0186 0.0308
Onchocerca volvulus 0.0043 0.0129 0.0721
Leishmania major glucose transporter, lmgt2 0.0095 0.0412 0.0627
Entamoeba histolytica acyl-CoA synthetase, putative 0.0149 0.0703 0.2878
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0129 0.0135
Loa Loa (eye worm) hypothetical protein 0.0111 0.0499 0.1491
Entamoeba histolytica hypothetical protein 0.0069 0.0267 0.0922
Trypanosoma brucei protein kinase, putative 0.0106 0.0468 0.0761
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0038 0.0099 0.0107
Brugia malayi hypothetical protein 0.0043 0.0129 0.0214
Trypanosoma brucei glucose transporter, putative 0.0095 0.0412 0.0667
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0092 0.0395 0.0654
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0045 0.0138 0.0078
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0055 0.0193 0.0204
Schistosoma mansoni glutaminase 0.0281 0.1419 0.2351
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0031 0.0061 0.0064
Plasmodium vivax sugar transporter, putative 0.0043 0.0129 0.0135
Loa Loa (eye worm) hypothetical protein 0.0149 0.0703 0.2102
Echinococcus multilocularis tar DNA binding protein 0.039 0.2013 0.2122
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0107 0.0478 0.0737
Echinococcus granulosus lysyl tRNA synthetase 0.0069 0.0267 0.0281
Echinococcus granulosus Sugar transporter ERD6 protein 0.0043 0.0129 0.0136
Loa Loa (eye worm) hypothetical protein 0.0241 0.1206 0.3603
Loa Loa (eye worm) hypothetical protein 0.0111 0.0499 0.1491
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0318 0.162 0.2639
Brugia malayi MH2 domain containing protein 0.0043 0.013 0.0215
Loa Loa (eye worm) MBCTL1 0.0105 0.0466 0.1392
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0044 0.0132 0.0102
Mycobacterium ulcerans acyl-CoA synthetase 0.0149 0.0703 0.1059
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.0386
Toxoplasma gondii exonuclease III APE 0.0055 0.0193 0.0285
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0092 0.0395 0.0416
Echinococcus multilocularis synaptic vesicle 2 protein 0.0043 0.0129 0.0136
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Giardia lamblia Kinase, CMGC MAPK 0.0106 0.0468 1
Brugia malayi lysyl-tRNA synthetase 0.0069 0.0267 0.0442
Schistosoma mansoni lysyl-tRNA synthetase 0.0069 0.0267 0.0442
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0044 0.0132 0.032
Schistosoma mansoni lysyl-tRNA synthetase 0.0069 0.0267 0.0442
Echinococcus granulosus mitogen activated protein kinase 0.0106 0.0468 0.0494
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0055 0.0193 0.0204
Loa Loa (eye worm) mbt repeat family protein 0.0092 0.0397 0.1185
Leishmania major hypothetical protein, conserved 0.0291 0.1477 0.2401
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.1132 0.6038 1
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0149 0.0703 0.1059
Plasmodium vivax acyl-CoA synthetase, putative 0.0111 0.0499 0.0668
Mycobacterium ulcerans esterase/lipase LipP 0.0291 0.1477 0.2355
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.1132 0.6038 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.0395 0.118
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.0386
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0132 0.0161
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0099 0.0173
Trichomonas vaginalis DNA polymerase eta, putative 0.0087 0.0366 0.1214
Toxoplasma gondii facilitative glucose transporter GT1 0.0307 0.1561 0.2559
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0366 0.0591
Echinococcus multilocularis solute carrier family 22 0.0043 0.0129 0.0136
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0132 0.0219
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0044 0.0132 0.0395
Onchocerca volvulus 0.0259 0.1299 0.7253
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0045 0.0138 0.0015
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0099 0.0107
Schistosoma mansoni acetyl-CoA synthetase 0.0044 0.0132 0.0219
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0307 0.1561 0.1646
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0366 0.0551
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Echinococcus multilocularis expressed protein 0.0039 0.0104 0.011
Schistosoma mansoni rotamase 0.0039 0.0104 0.0173
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0058 0.0211 0.0133
Echinococcus granulosus dna polymerase eta 0.0031 0.0061 0.0064
Onchocerca volvulus 0.0043 0.0129 0.0721
Brugia malayi Major Facilitator Superfamily protein 0.0043 0.0129 0.0214
Brugia malayi RNA recognition motif domain containing protein 0.039 0.2013 0.3334
Onchocerca volvulus 0.0043 0.0129 0.0721
Brugia malayi MAP kinase sur-1 0.0106 0.0468 0.0776
Plasmodium vivax CDK-related protein kinase 6, putative 0.1304 0.6972 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0149 0.0703 0.1113
Trichomonas vaginalis antibiotic synthetase, putative 0.0044 0.0132 0.015
Loa Loa (eye worm) hypothetical protein 0.0066 0.0251 0.0751
Schistosoma mansoni hypothetical protein 0.0307 0.1561 0.2586
Leishmania major myo-inositol/proton symporter (MIT) 0.0043 0.0129 0.0156
Trichomonas vaginalis sugar transporter, putative 0.0095 0.0412 0.1423
Echinococcus granulosus Smad4 0.0043 0.013 0.0137
Loa Loa (eye worm) glutaminase 0.0281 0.1419 0.4241
Schistosoma mansoni glucose transport protein 0.0307 0.1561 0.2586
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0039 0.0104 0.0312
Plasmodium falciparum calcium-dependent protein kinase 2 0.0095 0.041 0.054
Loa Loa (eye worm) hypothetical protein 0.0044 0.0132 0.0395
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0095 0.041 0.0432
Mycobacterium ulcerans bacterioferritin BfrB 0.0045 0.0138 0.0111
Trypanosoma brucei DNA polymerase IV, putative 0.0087 0.0366 0.0591
Brugia malayi hypothetical protein 0.0043 0.0129 0.0214
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0043 0.0129 0.0214
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.0386
Plasmodium vivax lysine--tRNA ligase, putative 0.0069 0.0267 0.0334
Onchocerca volvulus 0.0043 0.0129 0.0721
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0031 0.0061 0.0182
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0442 0.2294 0.2418
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0038 0.0099 0.0149
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0375 0.1932 0.2037
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0044 0.0132 0.0183
Onchocerca volvulus 0.0291 0.1477 0.8246
Echinococcus multilocularis musashi 0.0054 0.0186 0.0196
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0497 0.2592 0.3686
Trypanosoma cruzi hexose transporter, putative 0.0095 0.0412 0.0627
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Trypanosoma brucei unspecified product 0.0073 0.029 0.0466
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0149 0.0703 0.1059
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0106
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0149 0.0703 0.0967
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0069 0.0267 0.0763
Schistosoma mansoni survival motor neuron protein 0.0049 0.0162 0.0269
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0055 0.0193 0.0578
Mycobacterium ulcerans bacterioferritin BfrA 0.0045 0.0138 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0129 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0085 0.0126
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0044 0.0132 0.0102
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0095 0.041 0.0665
Onchocerca volvulus 0.0291 0.1477 0.8246
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0106 0.0468 0.0742
Onchocerca volvulus 0.0043 0.0129 0.0721
Echinococcus multilocularis mitogen activated protein kinase 3 0.0106 0.0468 0.0494
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0375 0.1932 0.2037
Brugia malayi Major Facilitator Superfamily protein 0.0043 0.0129 0.0214
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0095 0.041 0.0645
Leishmania major glucose transporter, lmgt1 0.0095 0.0412 0.0627
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0069 0.0267 0.0228
Loa Loa (eye worm) hypothetical protein 0.0105 0.0466 0.1392
Loa Loa (eye worm) hypothetical protein 0.0095 0.041 0.1225
Onchocerca volvulus 0.0043 0.0129 0.0721
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0044 0.0132 0.0072
Giardia lamblia Prolyl-tRNA synthetase 0.0092 0.0395 0.7833
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0468 0.1681
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0095 0.041 0.0645
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0044 0.0132 0.0102
Schistosoma mansoni ap endonuclease 0.0055 0.0193 0.032
Loa Loa (eye worm) sugar transporter 0.0043 0.0129 0.0386
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Loa Loa (eye worm) hypothetical protein 0.0044 0.0132 0.0395
Echinococcus granulosus smad 0.0043 0.013 0.0137
Trypanosoma brucei glucose transporter, putative 0.0095 0.0412 0.0667
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0044 0.0132 0.0395
Trypanosoma brucei glucose transporter, putative 0.0095 0.0412 0.0667
Mycobacterium tuberculosis Probable esterase LipL 0.0291 0.1477 0.1424
Mycobacterium tuberculosis Conserved protein 0.0291 0.1477 0.1424
Brugia malayi N-terminal motif family protein 0.0175 0.0847 0.1402
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0044 0.0132 0.0219
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0106 0.0468 0.0721
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0393 0.0415
Loa Loa (eye worm) hypothetical protein 0.0291 0.1477 0.4412
Loa Loa (eye worm) RNA binding protein 0.039 0.2013 0.6016
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0111 0.0499 0.0441
Echinococcus multilocularis solute carrier family 22 0.0043 0.0129 0.0136
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0442 0.2294 0.2418
Trypanosoma brucei DNA polymerase eta, putative 0.0031 0.0061 0.0085
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0132 0.0072
Loa Loa (eye worm) glutaminase 2 0.0281 0.1419 0.4241
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0291 0.1477 0.2445
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0058 0.0211 0.0151
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0055 0.0193 0.1894
Echinococcus granulosus TGF beta signal transducer SmadC 0.0043 0.013 0.0137
Brugia malayi beta-lactamase 0.0291 0.1477 0.2445
Echinococcus multilocularis beta LACTamase domain containing family member 0.0291 0.1477 0.1557
Mycobacterium ulcerans lipase LipD 0.0291 0.1477 0.2355
Loa Loa (eye worm) hypothetical protein 0.0053 0.0181 0.054
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Trypanosoma cruzi hexose transporter, putative 0.0052 0.0177 0.0236
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0393 0.0652
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0055 0.0193 0.0263
Brugia malayi beta-lactamase family protein 0.0291 0.1477 0.2445
Trichomonas vaginalis glutaminase, putative 0.0281 0.1419 0.6016
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0442 0.2294 0.2418
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0092 0.0395 0.0654
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0055 0.0193 0.0228
Schistosoma mansoni hypothetical protein 0.0049 0.0162 0.0269
Echinococcus multilocularis solute carrier family 22 0.0043 0.0129 0.0136
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0038 0.0099 0.0039
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0186 0.0556
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0132 0.0161
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Trichomonas vaginalis sugar transport protein, putative 0.0043 0.0129 0.0135
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0207 0.0343
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0044 0.0132 0.0072
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.1206 0.1271
Echinococcus multilocularis histone acetyltransferase MYST2 0.0105 0.0466 0.0491
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.1206 0.1271
Schistosoma mansoni apoferritin-2 0.0045 0.0138 0.0228
Loa Loa (eye worm) hypothetical protein 0.0111 0.0499 0.1491
Schistosoma mansoni lamin 0.0054 0.0186 0.0308
Trichomonas vaginalis penicillin-binding protein, putative 0.0291 0.1477 0.6276
Echinococcus granulosus polycomb protein SCMH1 0.0092 0.0397 0.0418
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0043 0.0129 0.0097
Mycobacterium ulcerans integral membrane transport protein 0.0043 0.0129 0.0097
Trypanosoma cruzi sugar transporter, putative 0.0043 0.0129 0.0156
Brugia malayi MH1 domain containing protein 0.0024 0.0025 0.0041
Brugia malayi Sugar transporter family protein 0.0307 0.1561 0.2586
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0095 0.041 0.0432
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0031 0.0061 0.0101
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0044 0.0132 0.0139
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.1132 0.6038 1
Echinococcus multilocularis Smad4 0.0043 0.013 0.0137
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0087 0.0366 0.1214
Plasmodium falciparum calcium-dependent protein kinase 4 0.0095 0.041 0.054
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0055 0.0193 0.0228
Brugia malayi ImpB/MucB/SamB family protein 0.0031 0.0061 0.0101
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0105 0.0466 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0412 0.1423
Onchocerca volvulus 0.0044 0.0132 0.0739
Onchocerca volvulus 0.0043 0.0129 0.0721
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0442 0.2294 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0069 0.0267 0.0327
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0095 0.041 0.0432
Brugia malayi MH1 domain containing protein 0.0043 0.013 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0137 0.0211
Loa Loa (eye worm) hypothetical protein 0.0111 0.0499 0.1491
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0044 0.0132 0.0161
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0393 0.0415
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0044 0.0132 0.0102
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0092 0.0395 0.0416
Onchocerca volvulus 0.0349 0.1791 1
Brugia malayi Zinc finger, C2H2 type family protein 0.0442 0.2294 0.3799
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.1132 0.6038 1
Toxoplasma gondii protein kinase, putative 0.0868 0.4608 0.7623
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0366 0.0591
Onchocerca volvulus 0.0054 0.0186 0.1039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0393 0.0652
Schistosoma mansoni ferritin 0.0045 0.0138 0.0228
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0468 0.1681
Brugia malayi mbt repeat family protein 0.0092 0.0397 0.0657
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0038 0.01 0.0299
Leishmania major hypothetical protein, conserved 0.0043 0.0129 0.0156
Leishmania major dihydroorotate dehydrogenase 0.1132 0.6038 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0318 0.162 0.2639
Mycobacterium ulcerans hypothetical protein 0.0291 0.1477 0.2355
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0105 0.0466 0.0408
Onchocerca volvulus 0.0043 0.0129 0.0721
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.0847 0.4728
Treponema pallidum exodeoxyribonuclease (exoA) 0.0055 0.0193 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0095 0.041 0.0432
Trichomonas vaginalis rotamase, putative 0.0039 0.0104 0.0022
Trichomonas vaginalis ap endonuclease, putative 0.0055 0.0193 0.0428
Echinococcus multilocularis General substrate transporter 0.0264 0.1327 0.1399
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.1132 0.6038 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0055 0.0193 0.0204
Trichomonas vaginalis ap endonuclease, putative 0.0055 0.0193 0.0428
Schistosoma mansoni protein kinase 0.0095 0.041 0.0679
Trypanosoma cruzi hypothetical protein, conserved 0.0291 0.1477 0.2401
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.0386
Brugia malayi polk-prov protein 0.0066 0.0251 0.0416
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0043 0.0129 0.0069
Mycobacterium ulcerans hypothetical protein 0.0354 0.1815 0.2922
Trichomonas vaginalis sugar transporter, putative 0.0095 0.0412 0.1423
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0829 0.4396 0.4634
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0104 0.0022
Plasmodium falciparum dihydroorotate dehydrogenase 0.1132 0.6038 0.8653
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.006 0.0221 0.0554
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Toxoplasma gondii lysine-tRNA ligase 0.0069 0.0267 0.0407
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0366 0.0551
Mycobacterium tuberculosis Probable lipase LipD 0.0291 0.1477 0.1424
Loa Loa (eye worm) nuclear factor I 0.0024 0.0025 0.0075
Brugia malayi beta-lactamase family protein 0.0291 0.1477 0.2445
Onchocerca volvulus Putative transporter 0.0043 0.0129 0.0721
Trichomonas vaginalis glucose transporter, putative 0.0095 0.0412 0.1423
Schistosoma mansoni smad 0.0043 0.013 0.0215
Brugia malayi AMP-binding enzyme family protein 0.0149 0.0703 0.1165
Echinococcus granulosus intermediate filament protein 0.0054 0.0186 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0412 0.1423
Trypanosoma cruzi hexose transporter, putative 0.0043 0.0129 0.0156
Loa Loa (eye worm) hypothetical protein 0.0291 0.1477 0.4412
Toxoplasma gondii sugar transporter ST1 0.0043 0.0129 0.0178
Brugia malayi Smad1 0.0043 0.013 0.0215
Echinococcus multilocularis smad 0.0043 0.013 0.0137
Loa Loa (eye worm) hypothetical protein 0.0291 0.1477 0.4412
Onchocerca volvulus 0.0043 0.0129 0.0721
Schistosoma mansoni glucose transport protein 0.0307 0.1561 0.2586
Trichomonas vaginalis penicillin-binding protein, putative 0.0291 0.1477 0.6276
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0111 0.0499 0.0717
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0132 0.0102
Plasmodium vivax calcium-dependent protein kinase, putative 0.0095 0.041 0.054
Mycobacterium ulcerans DNA polymerase IV 0.0087 0.0366 0.0493
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0468 0.1681
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0291 0.1477 0.4412
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0186 0.0308
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0058 0.0211 0.0151
Trypanosoma cruzi glucose transporter, putative 0.0043 0.0129 0.0156
Echinococcus granulosus solute carrier family 22 0.0043 0.0129 0.0136
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0055 0.0193 0.0109
Echinococcus multilocularis lysyl tRNA synthetase 0.0069 0.0267 0.0281
Mycobacterium ulcerans acetyl-CoA synthetase 0.0044 0.0132 0.0102
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.0386
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0207 0.0619
Echinococcus granulosus tar DNA binding protein 0.039 0.2013 0.2122
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0085 0.0126
Brugia malayi MH1 domain containing protein 0.0043 0.013 0.0215
Plasmodium falciparum calcium-dependent protein kinase 5 0.0095 0.041 0.054
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0132 0.0102
Brugia malayi MH2 domain containing protein 0.0636 0.3346 0.5542
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0106 0.0468 0.0721
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0105 0.0466 0.0491
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0207 0.0343
Loa Loa (eye worm) Smad1 0.0043 0.013 0.0389
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0132 0.0219
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0043 0.0129 0.0097
Mycobacterium leprae conserved hypothetical protein 0.0291 0.1477 0.2276
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0044 0.0132 0.0161
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.1132 0.6038 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0267 0.0797
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Trypanosoma brucei sugar transporter, putative 0.0043 0.0129 0.0199
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0106
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0106 0.0468 0.1399
Trypanosoma cruzi hexose transporter, putative 0.0095 0.0412 0.0627
Onchocerca volvulus 0.0044 0.0132 0.0739
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0105 0.0466 0.0408
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.1132 0.6038 0.8653
Echinococcus multilocularis dna polymerase eta 0.0031 0.0061 0.0064
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0045 0.0138 0.0078
Giardia lamblia Lysyl-tRNA synthetase 0.0069 0.0267 0.4059
Chlamydia trachomatis lysine--tRNA ligase 0.0069 0.0267 0.4569
Mycobacterium ulcerans DNA polymerase IV 0.0087 0.0366 0.0493
Brugia malayi exodeoxyribonuclease III family protein 0.0055 0.0193 0.032
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0106 0.0468 0.0761
Schistosoma mansoni sugar transporter 0.0043 0.0129 0.0214
Brugia malayi AMP-binding enzyme family protein 0.0149 0.0703 0.1165
Schistosoma mansoni terminal deoxycytidyl transferase 0.0031 0.0061 0.0101
Onchocerca volvulus 0.0092 0.0397 0.2215
Echinococcus multilocularis mothers against decapentaplegic 5 0.0043 0.013 0.0137
Echinococcus multilocularis SAM and MBT domain containing protein 0.0092 0.0397 0.0418
Loa Loa (eye worm) hypothetical protein 0.0092 0.0397 0.1185
Mycobacterium ulcerans acyl-CoA synthetase 0.0149 0.0703 0.1059
Schistosoma mansoni tar DNA-binding protein 0.039 0.2013 0.3334
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0055 0.0193 0.0263
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0095 0.041 0.0432
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0069 0.0267 0.0427
Loa Loa (eye worm) beta-lactamase 0.0291 0.1477 0.4412
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0307 0.1561 0.1646
Echinococcus granulosus solute carrier family 22 0.0043 0.0129 0.0136
Loa Loa (eye worm) hypothetical protein 0.0291 0.1477 0.4412
Mycobacterium tuberculosis Conserved protein 0.0291 0.1477 0.1424
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0055 0.0193 0.0593
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0044 0.0132 0.0072
Schistosoma mansoni smad1 5 8 and 0.0043 0.013 0.0215
Brugia malayi hypothetical protein 0.0043 0.0129 0.0214
Echinococcus granulosus mothers against decapentaplegic 5 0.0043 0.013 0.0137
Brugia malayi glutaminase DH11.1 0.0281 0.1419 0.2351
Loa Loa (eye worm) transcription factor SMAD2 0.0636 0.3346 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0095 0.041 0.054
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0307 0.1561 0.1646
Echinococcus granulosus ferritin 0.0045 0.0138 0.0145
Trichomonas vaginalis D-aminoacylase, putative 0.0291 0.1477 0.6276
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0107 0.0478 0.0777
Loa Loa (eye worm) MH2 domain-containing protein 0.0636 0.3346 1
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0095 0.041 0.0645
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0107 0.0478 0.0737
Trichomonas vaginalis D-aminoacylase, putative 0.0291 0.1477 0.6276
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0366 0.0591
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.0386
Schistosoma mansoni ferritin 0.0045 0.0138 0.0228
Trypanosoma brucei DNA polymerase IV, putative 0.0087 0.0366 0.0591
Leishmania major lysyl-tRNA synthetase, putative 0.0069 0.0267 0.0385
Schistosoma mansoni Smad4 0.0043 0.013 0.0215
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.039 0.2013 0.6016
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.0386
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0094 0.0407 0.062
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0095 0.041 0.054
Loa Loa (eye worm) hypothetical protein 0.0025 0.003 0.009
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.0386
Schistosoma mansoni tar DNA-binding protein 0.039 0.2013 0.3334
Leishmania major acetyl-CoA synthetase, putative 0.0044 0.0132 0.0161
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0162 0.0269
Brugia malayi intermediate filament protein 0.0054 0.0186 0.0308
Onchocerca volvulus 0.0291 0.1477 0.8246
Onchocerca volvulus 0.0043 0.0129 0.0721
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0107 0.0478 0.0737
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0186 0.0556
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0094 0.0407 0.062
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0055 0.0193 0.0133
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0291 0.1477 0.2445
Loa Loa (eye worm) hypothetical protein 0.0291 0.1477 0.4412
Echinococcus granulosus histone acetyltransferase MYST2 0.0105 0.0466 0.0491
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0251 0.0401
Plasmodium falciparum protein kinase 7 0.0868 0.4608 0.6591
Schistosoma mansoni cellular tumor antigen P53 0.0259 0.1299 0.2151
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0291 0.1477 0.2355
Echinococcus multilocularis lamin 0.0054 0.0186 0.0196
Schistosoma mansoni sugar transporter 0.0043 0.0129 0.0214
Loa Loa (eye worm) hypothetical protein 0.0024 0.0025 0.0075
Toxoplasma gondii sugar transporter ST3 0.0043 0.0129 0.0178
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Mycobacterium ulcerans acyl-CoA synthetase 0.0149 0.0703 0.1059
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0132 0.0102
Onchocerca volvulus 0.0043 0.0129 0.0721
Loa Loa (eye worm) hypothetical protein 0.0111 0.0499 0.1491
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0671 0.3539 0.5856
Leishmania major 4-coumarate:coa ligase-like protein 0.0149 0.0703 0.1113
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0044 0.0132 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0393 0.0652
Trypanosoma cruzi hexose transporter, putative 0.0095 0.0412 0.0627
Loa Loa (eye worm) major facilitator superfamily transporter 0.0043 0.0129 0.0386
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0307 0.1561 0.1646
Schistosoma mansoni hypothetical protein 0.0573 0.3005 0.4977
Loa Loa (eye worm) hypothetical protein 0.0039 0.0108 0.0324
Plasmodium falciparum protein kinase 6 0.1304 0.6972 1
Plasmodium falciparum proline--tRNA ligase 0.0107 0.0478 0.0637
Echinococcus multilocularis ferritin 0.0045 0.0138 0.0145
Schistosoma mansoni protein kinase 0.0095 0.041 0.0679
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0099 0.0107
Schistosoma mansoni ferritin 0.0045 0.0138 0.0228
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0132 0.0219
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0043 0.0129 0.0069
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0442 0.2294 0.3762
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0035 0.0043
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0132 0.0102
Brugia malayi major facilitator superfamily protein 0.0043 0.0129 0.0214
Mycobacterium ulcerans sugar transporter 0.0043 0.0129 0.0097
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Onchocerca volvulus 0.0149 0.0703 0.3929
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0095 0.041 0.1225
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0108 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0366 0.0591
Schistosoma mansoni DNA polymerase eta 0.0031 0.0061 0.0101
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0044 0.0132 0.0072
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Brugia malayi Sugar transporter family protein 0.0043 0.0129 0.0214
Loa Loa (eye worm) hypothetical protein 0.0025 0.003 0.009
Loa Loa (eye worm) hypothetical protein 0.0092 0.0395 0.118
Onchocerca volvulus 0.0043 0.0129 0.0721
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0442 0.2294 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0307 0.1561 0.1646
Echinococcus multilocularis dna polymerase kappa 0.0087 0.0366 0.0386
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Echinococcus granulosus synaptic vesicle 2 protein 0.0043 0.0129 0.0136
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0132 0.0219
Onchocerca volvulus 0.0044 0.0132 0.0739
Schistosoma mansoni sugar transporter 0.0043 0.0129 0.0214
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Toxoplasma gondii sugar transporter ST2 0.0043 0.0129 0.0178
Schistosoma mansoni myelin transcription factor 1 myt1 0.0105 0.0466 0.0772
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0366 0.0591
Brugia malayi hypothetical protein 0.0241 0.1206 0.1997
Trichomonas vaginalis glucose transporter, putative 0.0095 0.0412 0.1423
Schistosoma mansoni dihydroorotate dehydrogenase 0.1132 0.6038 1
Mycobacterium tuberculosis Probable lipase LipE 0.0291 0.1477 0.1424
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0132 0.0102
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0095 0.041 0.054
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0442 0.2294 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0044 0.0132 0.0102
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0092 0.0395 0.0654
Trypanosoma brucei hypothetical protein, conserved 0.0291 0.1477 0.2434
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0069 0.0267 0.0385
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.041 0.1415
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0043 0.0129 0.0199
Schistosoma mansoni smad1 5 8 and 0.0043 0.013 0.0215
Loa Loa (eye worm) hypothetical protein 0.0058 0.0207 0.0619
Echinococcus granulosus beta LACTamase domain containing family member 0.0291 0.1477 0.1557
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0132 0.0072
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0106 0.0468 0.0721
Trypanosoma brucei THT1 - hexose transporter, putative 0.0095 0.0412 0.0667
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0442 0.2294 1
Toxoplasma gondii hypothetical protein 0.0108 0.0483 0.0766
Schistosoma mansoni sex comb on midleg homolog 0.0092 0.0397 0.0657
Plasmodium falciparum calcium-dependent protein kinase 3 0.0095 0.041 0.054
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0307 0.1561 0.1646
Mycobacterium ulcerans beta-lactamase 0.0291 0.1477 0.2355
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0031 0.0061 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0393 0.0652
Mycobacterium tuberculosis Conserved protein 0.0291 0.1477 0.1424
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0044 0.0132 0.0072
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0291 0.1477 0.1424
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0092 0.0397 0.2215
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0045 0.0138 0.001
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0442 0.2294 1
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0044 0.0132 0.0183
Leishmania major protein kinase, putative 0.0095 0.041 0.0624
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0149 0.0703 0.1059
Schistosoma mansoni tar DNA-binding protein 0.039 0.2013 0.3334
Schistosoma mansoni protein kinase 0.0095 0.041 0.0679
Treponema pallidum bacterioferrin (TpF1) 0.0045 0.0138 0.5452
Toxoplasma gondii peptidylprolyl isomerase 0.0038 0.0099 0.0129
Trypanosoma cruzi hexose transporter 0.0095 0.0412 0.0627
Schistosoma mansoni tar DNA-binding protein 0.039 0.2013 0.3334
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0085 0.0126
Leishmania major glucose transporter/membrane transporter D2, putative 0.0095 0.0412 0.0627
Entamoeba histolytica acyl-CoA synthetase, putative 0.0149 0.0703 0.2878
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0132 0.0102
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.0386
Onchocerca volvulus 0.0043 0.0129 0.0721
Trichomonas vaginalis antibiotic synthetase, putative 0.0044 0.0132 0.015
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0105 0.0466 0.0772
Loa Loa (eye worm) sugar transporter 0.0307 0.1561 0.4665
Loa Loa (eye worm) hypothetical protein 0.0149 0.0703 0.2102
Entamoeba histolytica acyl-coA synthetase, putative 0.0149 0.0703 0.2878
Echinococcus granulosus calcium dependent protein kinase 0.0088 0.0374 0.0394
Trichomonas vaginalis sugar transporter, putative 0.0095 0.0412 0.1423
Schistosoma mansoni ferritin light chain 0.0045 0.0138 0.0228
Brugia malayi RNA binding protein 0.039 0.2013 0.3334
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.0386
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0069 0.0267 0.0327
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0671 0.3539 0.5838
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0055 0.0193 0.0263
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0132 0.0072
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0043 0.013 0.0215
Trypanosoma brucei THT1 - hexose transporter, putative 0.0095 0.0412 0.0667
Schistosoma mansoni ferritin light chain 0.0045 0.0138 0.0228
Mycobacterium leprae Probable lipase LipE 0.0291 0.1477 0.2276
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0115 0.0519 0.0806
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0132 0.0072
Toxoplasma gondii transporter, major facilitator family protein 0.0043 0.0129 0.0178
Onchocerca volvulus 0.0043 0.0129 0.0721
Plasmodium falciparum lysine--tRNA ligase 0.0069 0.0267 0.0334
Brugia malayi major facilitator superfamily protein 0.0043 0.0129 0.0214
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0035 0.0037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0105 0.0466 0.0408
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0035 0.0037
Entamoeba histolytica protein kinase, putative 0.0095 0.041 0.1564
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Echinococcus multilocularis lamin dm0 0.0054 0.0186 0.0196
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0092 0.0395 0.1496
Schistosoma mansoni smad1 5 8 and 0.0043 0.013 0.0215
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0393 0.0415
Loa Loa (eye worm) hypothetical protein 0.0149 0.0703 0.2102
Trypanosoma brucei glucose transporter, putative 0.0095 0.0412 0.0667
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0092 0.0395 0.0654
Loa Loa (eye worm) hypothetical protein 0.0175 0.0847 0.253
Brugia malayi Cam kinase protein 1 0.0095 0.041 0.0679
Brugia malayi hypothetical protein 0.0349 0.1791 0.2966
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0095 0.041 0.1225
Trichomonas vaginalis D-aminoacylase, putative 0.0291 0.1477 0.6276
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0107 0.0478 0.0757
Trichomonas vaginalis myo-inositol transporter, putative 0.0043 0.0129 0.0135
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0132 0.0204
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0106 0.0468 0.0721
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0043 0.013 0.0137
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0132 0.0219
Echinococcus multilocularis mitogen activated protein kinase 0.0106 0.0468 0.0494
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0044 0.0132 0.0072
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0393 0.1176
Schistosoma mansoni ap endonuclease 0.0055 0.0193 0.032
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0044 0.0132 0.0102
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.1132 0.6038 1
Plasmodium vivax hexose transporter 0.0307 0.1561 0.22
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0061 0.0042
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0149 0.0703 0.1059
Loa Loa (eye worm) hypothetical protein 0.0291 0.1477 0.4412
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0132 0.0102
Loa Loa (eye worm) hypothetical protein 0.0349 0.1791 0.5351
Brugia malayi Major Facilitator Superfamily protein 0.0043 0.0129 0.0214
Schistosoma mansoni hypothetical protein 0.0039 0.0108 0.018
Schistosoma mansoni glucose transporter 0.0043 0.0129 0.0214
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.0386
Mycobacterium ulcerans glutaminase 0.0281 0.1419 0.2259
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0092 0.0395 0.0445
Onchocerca volvulus 0.0043 0.0129 0.0721
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0044 0.0132 0.0102
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0442 0.2294 0.2418
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0095 0.041 0.0679
Plasmodium vivax proline--tRNA ligase, putative 0.0107 0.0478 0.0637
Trypanosoma brucei glucose transporter, putative 0.0095 0.0412 0.0667
Brugia malayi ImpB/MucB/SamB family protein 0.0031 0.0061 0.0101
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0366 0.0551
Schistosoma mansoni tar DNA-binding protein 0.039 0.2013 0.3334
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0442 0.2294 1
Onchocerca volvulus 0.0044 0.0132 0.0739
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.1132 0.6038 1
Echinococcus multilocularis tumor protein p63 0.1767 0.9486 1
Brugia malayi MH1 domain containing protein 0.0024 0.0025 0.0041
Brugia malayi TAR-binding protein 0.039 0.2013 0.3334
Echinococcus multilocularis calcium dependent protein kinase 0.0088 0.0374 0.0394
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0468 0.0776
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0043 0.0129 0.0136
Schistosoma mansoni intermediate filament proteins 0.0054 0.0186 0.0308
Schistosoma mansoni ferritin 0.0045 0.0138 0.0228
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0307 0.1561 0.1646
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0182
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0149 0.0703 0.0967
Trypanosoma brucei glucose transporter 1E 0.0095 0.0412 0.0667
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0106 0.0468 0.0721
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0044 0.0132 0.0139
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0307 0.1561 0.1646
Leishmania major acetyl-CoA synthetase, putative 0.0044 0.0132 0.0161
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0044 0.0132 0.0102
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0291 0.1477 0.1424
Entamoeba histolytica protein kinase, putative 0.0095 0.041 0.1564
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0107 0.0478 0.0737
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0318 0.162 0.2671
Echinococcus granulosus lamin 0.0054 0.0186 0.0196
Plasmodium vivax acetyl-CoA synthetase, putative 0.0044 0.0132 0.014
Loa Loa (eye worm) oxidoreductase 0.0044 0.0132 0.0395
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0051 0.0084
Echinococcus multilocularis solute carrier family 22 0.0043 0.0129 0.0136
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0149 0.0703 0.0647
Onchocerca volvulus 0.0049 0.0162 0.0906
Leishmania major 4-coumarate:coa ligase-like protein 0.0149 0.0703 0.1113
Loa Loa (eye worm) TAR-binding protein 0.039 0.2013 0.6016
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0291 0.1477 0.1424
Brugia malayi mbt repeat family protein 0.0092 0.0397 0.0657
Echinococcus multilocularis polycomb protein SCMH1 0.0092 0.0397 0.0418
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0094 0.0407 0.062
Schistosoma mansoni sugar transporter 0.0043 0.0129 0.0214
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Schistosoma mansoni sex comb on midleg homolog 0.0092 0.0397 0.0657
Trypanosoma brucei glucose transporter, putative 0.0095 0.0412 0.0667
Onchocerca volvulus 0.0054 0.0186 0.1039
Leishmania major glucose transporter, lmgt3 0.0095 0.0412 0.0627
Brugia malayi MH2 domain containing protein 0.0043 0.013 0.0215
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0111 0.0499 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.0386
Trypanosoma brucei glucose transporter 2A 0.0095 0.0412 0.0667
Echinococcus granulosus solute carrier family 22 0.0043 0.0129 0.0136
Echinococcus granulosus expressed protein 0.0039 0.0104 0.011
Brugia malayi hypothetical protein 0.0026 0.0035 0.0059
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0044 0.0132 0.0204
Echinococcus granulosus dna polymerase kappa 0.0087 0.0366 0.0386
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0132 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0366 0.0591
Loa Loa (eye worm) major facilitator superfamily transporter 0.0043 0.0129 0.0386
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.1132 0.6038 0.6014
Loa Loa (eye worm) MH1 domain-containing protein 0.0043 0.013 0.0389
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0442 0.2294 1
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0039 0.0104 0.0173
Toxoplasma gondii ABC1 family protein 0.0291 0.1477 0.2418
Trichomonas vaginalis glucose transporter, putative 0.0043 0.0129 0.0135
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.013 0.0389
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0035 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0251 0.0401
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0291 0.1477 0.2445
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.0386
Echinococcus multilocularis expressed protein 0.0045 0.0138 0.0145
Echinococcus granulosus SAM and MBT domain containing protein 0.0092 0.0397 0.0418
Mycobacterium tuberculosis Conserved hypothetical protein 0.0354 0.1815 0.1764
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0497 0.2592 0.4273
Echinococcus granulosus expressed protein 0.0045 0.0138 0.0145
Trypanosoma cruzi hypothetical protein, conserved 0.0291 0.1477 0.2401
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Trypanosoma brucei glucose transporter, putative 0.0095 0.0412 0.0667
Loa Loa (eye worm) hypothetical protein 0.0075 0.0301 0.09
Echinococcus granulosus General substrate transporter 0.0264 0.1327 0.1399
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0045 0.0137 0.0168
Plasmodium falciparum mitogen-activated protein kinase 2 0.0497 0.2592 0.3686
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0366 0.0591
Trichomonas vaginalis sugar transporter, putative 0.0043 0.0129 0.0135
Plasmodium falciparum hexose transporter 0.0307 0.1561 0.22
Trichomonas vaginalis conserved hypothetical protein 0.0307 0.1561 0.6662
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0092 0.0397 0.0657
Leishmania major mitochondrial DNA polymerase beta 0.0671 0.3539 0.5838

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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