Detailed information for compound 767011

Basic information

Technical information
  • TDR Targets ID: 767011
  • Name: 2-(4,6-dimethylpyrimidin-2-yl)-1-(2-fluorophe nyl)guanidine
  • MW: 259.282 | Formula: C13H14FN5
  • H donors: 2 H acceptors: 2 LogP: 1.88 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=Nc1nc(C)cc(n1)C)Nc1ccccc1F
  • InChi: 1S/C13H14FN5/c1-8-7-9(2)17-13(16-8)19-12(15)18-11-6-4-3-5-10(11)14/h3-7H,1-2H3,(H3,15,16,17,18,19)
  • InChiKey: ICOUGUQUSJHRMY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4,6-dimethyl-2-pyrimidinyl)-1-(2-fluorophenyl)guanidine
  • STK100878
  • BAS 06107459
  • N-(4,6-Dimethyl-pyrimidin-2-yl)-N'-(2-fluoro-phenyl)-guanidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans acyl-CoA synthetase 0.01 0.1289 0.3428
Loa Loa (eye worm) troponin I 0.0109 0.1428 0.3886
Plasmodium vivax glutathione reductase, putative 0.0037 0.041 0.1631
Toxoplasma gondii PAN domain-containing protein 0.0319 0.4369 1
Schistosoma mansoni acetyl-CoA synthetase 0.0029 0.0301 0.028
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0071 0.0565
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0029 0.0301 0.2237
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0372 0.0806
Entamoeba histolytica acyl-CoA synthetase, putative 0.01 0.1289 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.1428 0.3886
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0029 0.0301 0.101
Leishmania major DNA polymerase eta, putative 0.0031 0.0322 0.2501
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.1206 0.4839
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.0795
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0071 0.0027
Onchocerca volvulus 0.0029 0.0301 0.1492
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0193 0.0475
Schistosoma mansoni hypothetical protein 0.0035 0.0381 0.036
Toxoplasma gondii calcium binding egf domain-containing protein 0.0014 0.0084 0.0144
Schistosoma mansoni egf-like domain protein 0.0014 0.0084 0.0063
Giardia lamblia Sgs1 DNA helicase, putative 0.0018 0.0148 0.0728
Onchocerca volvulus 0.0014 0.009 0.0288
Schistosoma mansoni DNA helicase recq5 0.0018 0.0148 0.0126
Brugia malayi Trypsin family protein 0.0014 0.009 0.0184
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.1074 0.428
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0018 0.0143 0.1107
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0301 0.101
Toxoplasma gondii exonuclease III APE 0.0018 0.0149 0.0292
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.0795
Loa Loa (eye worm) Plcb4 protein 0.0018 0.0143 0.0334
Loa Loa (eye worm) hypothetical protein 0.0018 0.0143 0.0334
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0039 0.0017
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.041 0.1631
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.1074 0.428
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0019 0.0158 0.0376
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0149 0.0241
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0019 0.0158 0.0119
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0301 0.101
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0208 0.2815 0.7721
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.01 0.1289 0.3428
Onchocerca volvulus 0.0014 0.009 0.0288
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0071 0.0548
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0118 0.0079
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0878 0.3452
Schistosoma mansoni coup transcription factor 0.0011 0.0039 0.0017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0071 0.0565
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0071 0.0081
Loa Loa (eye worm) TK/ROR protein kinase 0.0053 0.0635 0.1695
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0029 0.0301 0.0667
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.009 0.0068
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0019 0.0158 0.0119
Echinococcus granulosus transmembrane protease serine 3 0.0014 0.009 0.0051
Onchocerca volvulus 0.0034 0.0372 0.1894
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.009 0.0068
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.1074 0.428
Loa Loa (eye worm) hypothetical protein 0.0029 0.0301 0.0773
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.009 0.0068
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0223 0.1731
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0039 0.0048
Mycobacterium ulcerans glutaminase 0.0267 0.364 1
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0039 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0039 0.0044
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0071 0.0081
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0418 0.038
Loa Loa (eye worm) hypothetical protein 0.0044 0.0505 0.1335
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.125 0.3323
Onchocerca volvulus 0.0014 0.009 0.0288
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0029 0.0301 0.0667
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0039 0.0044
Schistosoma mansoni hypothetical protein 0.0016 0.0118 0.0096
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0014 0.0084 0.017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0039 0.0044
Mycobacterium ulcerans hypothetical protein 0.01 0.1289 0.3428
Brugia malayi Protein kinase domain containing protein 0.0053 0.0635 0.1692
Brugia malayi phospholipase C homolog 0.0011 0.0052 0.008
Echinococcus granulosus laminin 0.0014 0.0084 0.0046
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.015 0.0354
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0039 0.0017
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0073 0.091 0.7062
Loa Loa (eye worm) hypothetical protein 0.0074 0.0935 0.2526
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0039 0.0017
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0071 0.0565
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.091 0.2373
Schistosoma mansoni hypothetical protein 0.0016 0.0118 0.0096
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0029 0.0301 0.101
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0505 0.1333
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.01 0.1289 0.5188
Onchocerca volvulus 0.01 0.1289 0.7108
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0039 0.0044
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0189 0.0357
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0071 0.0548
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0039 0.0048
Schistosoma mansoni casein kinase II beta subunit 0.0073 0.091 0.089
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.1074 0.428
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0417 0.0379
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0073 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0039 0.0044
Brugia malayi PAN domain containing protein 0.0034 0.0372 0.0965
Onchocerca volvulus 0.0034 0.0372 0.1894
Onchocerca volvulus 0.0029 0.0301 0.1492
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.0513 0.1262
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0149 0.011
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0149 0.1038
Giardia lamblia Casein kinase II beta chain 0.0021 0.0189 0.1073
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.018 0.2426 1
Leishmania major hypothetical protein, conserved 0.0053 0.0635 0.4927
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0149 0.0738
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.091 0.2373
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.125 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0372 0.0968
Schistosoma mansoni ap endonuclease 0.0018 0.0149 0.0127
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0372 0.0968
Echinococcus granulosus GPCR family 2 0.0016 0.0118 0.0079
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0148 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.0795
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0071 0.0132
Onchocerca volvulus Arrow homolog 0.0014 0.0084 0.0258
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0608 0.1619
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.009 0.0068
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0189 0.0357
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0021 0.0189 0.0357
Onchocerca volvulus 0.0014 0.009 0.0288
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.018 0.2426 0.6607
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0148 0.029
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0156 0.0264
Echinococcus granulosus dna polymerase eta 0.0044 0.0505 0.0468
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.0513 0.1354
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0061 0.0488
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0029 0.0301 0.101
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0071 0.0032
Brugia malayi steroid hormone receptor 0.0011 0.0039 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.0795
Echinococcus granulosus CTD small phosphatase protein like 0.0012 0.0061 0.0022
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0156 0.0393
Echinococcus granulosus Mastin 0.0014 0.009 0.0051
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0418 0.038
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0173
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0149 0.0365
Mycobacterium tuberculosis Probable reductase 0.0084 0.1074 0.428
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0608 0.1621
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0012 0.0063 0.05
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0118 0.0263
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0039 0.0017
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0061 0.0184
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.091 0.2373
Onchocerca volvulus 0.0034 0.0372 0.1894
Loa Loa (eye worm) hypothetical protein 0.0034 0.0372 0.0968
Plasmodium falciparum thioredoxin reductase 0.0037 0.041 0.1474
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0071 0.0548
Echinococcus multilocularis Tolloid protein 1 0.0014 0.0084 0.0046
Loa Loa (eye worm) hypothetical protein 0.0034 0.0372 0.0968
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0073 0.091 0.4955
Loa Loa (eye worm) hypothetical protein 0.0074 0.0935 0.2526
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0156 0.0134
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0012 0.0063 0.05
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0071 0.0548
Brugia malayi Trypsin family protein 0.0014 0.009 0.0184
Brugia malayi Thioredoxin reductase 0.0037 0.041 0.1069
Loa Loa (eye worm) troponin T 0.0065 0.0803 0.2158
Loa Loa (eye worm) hypothetical protein 0.0035 0.0381 0.0994
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0071 0.0041
Loa Loa (eye worm) hypothetical protein 0.01 0.1289 0.3502
Plasmodium falciparum casein kinase II beta chain 0.0073 0.091 0.3591
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0156 0.026
Loa Loa (eye worm) RecQ helicase 0.0044 0.0513 0.1357
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.009 0.0068
Loa Loa (eye worm) Csnk2b protein 0.0073 0.091 0.2456
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0301 0.241
Plasmodium falciparum casein kinase II beta chain 0.0073 0.091 0.3591
Loa Loa (eye worm) trypsin family protein 0.0014 0.009 0.0187
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0029 0.0301 0.0643
Loa Loa (eye worm) oxidoreductase 0.0012 0.0063 0.0113
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.125 0.3396
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0014 0.009 0.0051
Echinococcus multilocularis troponin i 0.0109 0.1428 0.1394
Schistosoma mansoni hypothetical protein 0.0012 0.0059 0.0037
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0034 0.0372 0.0806
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0141 0.012
Leishmania major DNA polymerase eta, putative 0.0044 0.0505 0.3917
Plasmodium vivax acetyl-CoA synthetase, putative 0.0029 0.0301 0.1181
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0012 0.0063 0.0094
Loa Loa (eye worm) retinol dehydrogenase 12 0.0012 0.0063 0.0113
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0074 0.0935 0.3693
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0301 0.241
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0014 0.009 0.0051
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0071 0.0034
Leishmania major hypothetical protein, conserved 0.0016 0.0115 0.0894
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0223 0.0453
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0301 0.241
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0071 0.0113
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0063 0.011
Echinococcus granulosus dna polymerase kappa 0.0019 0.0156 0.0117
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.041 0.3276
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0029 0.0301 0.077
Onchocerca volvulus 0.0034 0.0372 0.1894
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0505 0.4038
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0073 0.091 0.7024
Loa Loa (eye worm) hypothetical protein 0.0034 0.0372 0.0968
Trypanosoma brucei unspecified product 0.0019 0.0156 0.0795
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0014 0.0084 0.0173
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0301 0.077
Schistosoma mansoni kinase 0.0049 0.0582 0.0561
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0301 0.077
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0071 0.0565
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0071 0.0034
Schistosoma mansoni troponin I 0.0109 0.1428 0.1409
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0019 0.0158 0.1263
Brugia malayi Kringle domain containing protein 0.0053 0.0635 0.1692
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0039 0.0017
Toxoplasma gondii kringle domain-containing protein 0.0053 0.0635 0.1411
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0011 0.0052 0.003
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0149 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0141 0.012
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0301 0.0667
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.009 0.0068
Brugia malayi Troponin T 0.0065 0.0803 0.2156
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0635 0.5078
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0071 0.0081
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0071 0.0565
Brugia malayi Variant SH3 domain containing protein 0.0131 0.1731 0.4724
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0039 0.0017
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.1074 0.428
Loa Loa (eye worm) hypothetical protein 0.004 0.0454 0.1194
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0029 0.0301 0.101
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0018 0.0143 0.1107
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0073 0.091 0.4955
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0039 0.0048
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0012 0.0063 0.0485
Onchocerca volvulus 0.0019 0.0158 0.0676
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0019 0.0158 0.0373
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0061 0.0184
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0048
Brugia malayi Bromodomain containing protein 0.0078 0.0991 0.2676
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0012 0.0063 0.0485
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.0795
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0039 0.0044
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0012 0.0061 0.0022
Loa Loa (eye worm) casein kinase II 0.0021 0.0189 0.0461
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0029 0.0301 0.077
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0156 0.1244
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.0795
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0187
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0372 0.0968
Leishmania major 4-coumarate:coa ligase-like protein 0.01 0.1289 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0149 0.0738
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0301 0.101
Giardia lamblia DINP protein human, muc B family 0.0019 0.0156 0.0795
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0156 0.1244
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0039 0.0044
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0301 0.0667
Onchocerca volvulus 0.0034 0.0372 0.1894
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0301 0.0667
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.125 0.3323
Mycobacterium ulcerans acetyl-CoA synthetase 0.0029 0.0301 0.0667
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.0143 0.0331
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.091 0.2373
Brugia malayi Csnk2b protein 0.0073 0.091 0.2453
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0372 0.0968
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0187
Echinococcus granulosus troponin i 0.0109 0.1428 0.1394
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0935 0.244
Brugia malayi nuclear receptor NHR-88 0.0011 0.0039 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0039 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.125 0.3323
Loa Loa (eye worm) hypothetical protein 0.01 0.1289 0.3502
Brugia malayi Troponin I 0.0109 0.1428 0.3884
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0156 0.026
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.091 0.2373
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0012 0.0063 0.0094
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0149 0.011
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0311 0.1223
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0513 0.1262
Plasmodium vivax phospholipase C-like, putative 0.0018 0.0143 0.0523
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0766 0.073
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0437 0.159
Brugia malayi PAN domain containing protein 0.0034 0.0372 0.0965
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0148 0.0348
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0301 0.2338
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0156 0.0117
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0149 0.0365
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0148 0.0109
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0223 0.1363
Brugia malayi PAN domain containing protein 0.0034 0.0372 0.0965
Loa Loa (eye worm) hypothetical protein 0.0018 0.0148 0.0348
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0071 0.0034
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0019 0.0158 0.0313
Toxoplasma gondii PAN/Apple domain-containing protein 0.0034 0.0372 0.0806
Echinococcus granulosus enteropeptidase 0.0014 0.009 0.0051
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0039 0.0044
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0189 0.0357
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0029 0.0301 0.0263
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0173
Schistosoma mansoni ap endonuclease 0.0018 0.0149 0.0127
Mycobacterium ulcerans acyl-CoA synthetase 0.01 0.1289 0.3428
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0141 0.0102
Brugia malayi Trypsin-like protease protein 5 0.0014 0.009 0.0184
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.091 0.2373
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0306 0.0655
Loa Loa (eye worm) hypothetical protein 0.0034 0.0372 0.0968
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0048
Schistosoma mansoni troponin t invertebrate 0.0136 0.1797 0.178
Onchocerca volvulus 0.0034 0.0372 0.1894
Trypanosoma cruzi ISWI complex protein 0.0016 0.0115 0.0922
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0065 0.0803 0.4342
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0039 0.0017
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0012 0.0063 0.0485
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.125 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0878 0.3452
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0071 0.0049
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0141 0.0102
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0012 0.0063 0.0041
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0322 0.0692
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.041 0.1072
Brugia malayi AMP-binding enzyme family protein 0.01 0.1289 0.35
Onchocerca volvulus 0.0012 0.0063 0.0134
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0189 0.0357
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0039 0.0044
Onchocerca volvulus 0.0034 0.0372 0.1894
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0156 0.0134
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0012 0.0063 0.0024
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0148 0.029
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.091 0.2373
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.009 0.0068
Entamoeba histolytica acyl-coA synthetase, putative 0.01 0.1289 1
Toxoplasma gondii propionate-CoA ligase 0.0029 0.0301 0.0643
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0018 0.0143 0.0331
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.01 0.1289 0.5188
Toxoplasma gondii microneme protein, putative 0.0034 0.0372 0.0806
Schistosoma mansoni bromodomain containing protein 0.0066 0.0819 0.0799
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0148 0.0345
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0061 0.0039
Loa Loa (eye worm) hypothetical protein 0.0065 0.0803 0.2158
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0029 0.0301 0.0263
Brugia malayi Fibulin-1 precursor 0.0014 0.0084 0.017
Toxoplasma gondii subtilisin SUB12 0.0034 0.0372 0.0806
Echinococcus granulosus zinc finger protein 0.002 0.0178 0.014
Loa Loa (eye worm) hypothetical protein 0.0029 0.0301 0.0773
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0039 0.0017
Leishmania major phospholipase c-like protein 0.0022 0.0205 0.1592
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0071 0.0034
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0149 0.0245
Echinococcus multilocularis Mastin 0.0014 0.009 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.0795
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0014 0.009 0.0068
Loa Loa (eye worm) glutaminase 0.0267 0.364 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0048
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0071 0.0565
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0029 0.0301 0.0643
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0222 0.0183
Echinococcus multilocularis casein kinase ii subunit beta 0.0073 0.091 0.0875
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0141 0.012
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0223 0.1622
Schistosoma mansoni troponin I 0.0109 0.1428 0.1409
Trypanosoma brucei unspecified product 0.0013 0.0073 0.0104
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0048
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0301 0.0667
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.009 0.0068
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0372 0.0968
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0223 0.1784
Brugia malayi Troponin T 0.0065 0.0803 0.2156
Loa Loa (eye worm) hypothetical protein 0.0045 0.0516 0.1367
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0029 0.0301 0.101
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.0795
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0103
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0074 0.0935 0.3693
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0073 0.0104
Leishmania major trypanothione reductase 0.0037 0.041 0.3178
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0173
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.009 0.0068
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0073 0.091 0.728
Plasmodium falciparum thioredoxin reductase 0.0013 0.0071 0.0041
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0149 0.0548
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0417 0.0379
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0012 0.0063 0.05
Onchocerca volvulus 0.0034 0.0372 0.1894
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0071 0.0023
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.018 0.2426 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0156 0.0367
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0039 0.0017
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0301 0.2021
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0301 0.0773
Onchocerca volvulus 0.0029 0.0301 0.1492
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0021 0.0189 0.0357
Schistosoma mansoni dihydropteridine reductase 0.0012 0.0063 0.0041
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0156 0.1244
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0071 0.0023
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0019 0.0158 0.0814
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0029 0.0301 0.2021
Toxoplasma gondii microneme protein MIC17C 0.0034 0.0372 0.0806
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.009 0.0068
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0187
Plasmodium falciparum glutathione reductase 0.0037 0.041 0.1474
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0071 0.0113
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.009 0.0068
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0014 0.0084 0.0173
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.009 0.0068
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0109
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.009 0.0068
Mycobacterium ulcerans hypothetical protein 0.0014 0.009 0.0075
Leishmania major DNA polymerase kappa, putative 0.0019 0.0156 0.1207
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.01 0.1289 0.5188
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0071 0.0565
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0187
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0071 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0039 0.0044
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0189 0.0357
Echinococcus multilocularis 0.0012 0.0061 0.0022
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0156 0.1207
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0029 0.0301 0.1016
Leishmania major 4-coumarate:coa ligase-like protein 0.01 0.1289 1
Brugia malayi Trypsin family protein 0.0014 0.009 0.0184
Onchocerca volvulus Troponin I homolog 0.0109 0.1428 0.7898
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0156 0.0795
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0118 0.0266
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0012 0.0061 0.009
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.0382 0.0361
Trypanosoma brucei ISWI complex protein 0.0016 0.0115 0.0456
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.091 0.2373
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.1206 0.4839
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0073 0.091 0.2044
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.1206 0.4839
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.018 0.2426 1
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0372 0.0806
Schistosoma mansoni hypothetical protein 0.0022 0.0193 0.0172
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0564 0.1405
Toxoplasma gondii microneme protein MIC4 0.0034 0.0372 0.0806
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0029 0.0301 0.0667
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0014 0.0084 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0039 0.0044
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0156 0.0795
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0012 0.0061 0.0348
Loa Loa (eye worm) hypothetical protein 0.0012 0.0063 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.0795
Echinococcus multilocularis microtubule associated protein 2 0.072 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0189 0.0357
Leishmania major hypothetical protein, conserved 0.0012 0.0061 0.0474
Entamoeba histolytica acyl-CoA synthetase, putative 0.01 0.1289 1
Schistosoma mansoni hypothetical protein 0.0016 0.0115 0.0094
Onchocerca volvulus 0.0019 0.0158 0.0676
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0071 0.0565
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.125 0.3394
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0301 0.0671
Brugia malayi PAN domain containing protein 0.0034 0.0372 0.0965
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0189 0.0357
Brugia malayi PHD-finger family protein 0.0026 0.0256 0.0645
Entamoeba histolytica recQ family DNA helicase 0.0009 0.0022 0.0039
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0301 0.077
Trypanosoma brucei unspecified product 0.0013 0.0073 0.0104
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0029 0.0301 0.0667
Plasmodium falciparum acyl-CoA synthetase 0.0074 0.0935 0.3697
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0187
Giardia lamblia Casein kinase II beta chain 0.0073 0.091 0.7141
Onchocerca volvulus 0.0034 0.0372 0.1894
Loa Loa (eye worm) hypothetical protein 0.01 0.1289 0.3502
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0048
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0018 0.0143 0.0345
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.018 0.2426 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0173
Echinococcus multilocularis GPCR, family 2 0.0016 0.0118 0.0079
Toxoplasma gondii hypothetical protein 0.0034 0.0372 0.0806
Loa Loa (eye worm) hypothetical protein 0.0074 0.0935 0.2526
Plasmodium falciparum enoyl-acyl carrier reductase 0.018 0.2426 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0301 0.0773
Loa Loa (eye worm) troponin 0.0065 0.0803 0.2158
Loa Loa (eye worm) hypothetical protein 0.0034 0.0372 0.0968
Trypanosoma brucei trypanothione reductase 0.0037 0.041 0.2931
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0048
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.01 0.1289 0.3428
Brugia malayi Troponin family protein 0.0109 0.1428 0.3884
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.125 0.1216
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0564 0.1405
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0014 0.009 0.0184
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0073 0.091 0.7024
Toxoplasma gondii microneme protein MIC17A 0.0034 0.0372 0.0806
Onchocerca volvulus 0.0053 0.0635 0.339
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0149 0.119
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0189 0.0357
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.091 0.2373
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0156 0.1091
Loa Loa (eye worm) hypothetical protein 0.0074 0.0935 0.2526
Schistosoma mansoni troponin I 0.0109 0.1428 0.1409
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0301 0.2338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0039 0.0048
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.009 0.0068
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0073 0.091 0.7141
Schistosoma mansoni DNA polymerase eta 0.0044 0.0505 0.0484
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0301 0.241
Loa Loa (eye worm) hypothetical protein 0.0016 0.0118 0.0266
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.041 0.1468
Brugia malayi PAN domain containing protein 0.0034 0.0372 0.0965
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0029 0.0301 0.0667
Schistosoma mansoni troponin I 0.0109 0.1428 0.1409
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0071 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.125 0.3323
Echinococcus granulosus tissue type plasminogen activator 0.0053 0.0635 0.0598
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0149 0.0371
Trichomonas vaginalis glutaminase, putative 0.0267 0.364 1
Plasmodium vivax enoyl-acyl carrier protein reductase 0.018 0.2426 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.125 0.1216
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0063 0.011
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.1074 0.428
Echinococcus multilocularis zinc finger protein 0.002 0.0178 0.014
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0372 0.0806
Loa Loa (eye worm) hypothetical protein 0.0019 0.0158 0.0376
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0073 0.091 0.728
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0301 0.0667
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0029 0.0301 0.101
Plasmodium vivax casein kinase II beta chain, putative 0.0073 0.091 0.3709
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0372 0.0968
Schistosoma mansoni zinc finger protein 0.0016 0.0115 0.0094
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0136 0.1797 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0071 0.0224
Mycobacterium ulcerans acyl-CoA synthetase 0.01 0.1289 0.3428
Brugia malayi casein kinase II, putaitve 0.0021 0.0189 0.0458
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0071 0.0565
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0187
Brugia malayi hypothetical protein 0.0014 0.009 0.0184
Schistosoma mansoni microtubule-associated protein tau 0.072 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0156 0.0795
Echinococcus multilocularis dna polymerase eta 0.0044 0.0505 0.0468
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0156 0.0393
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0012 0.0061 0.0105
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.125 0.3323
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0141 0.0102
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0301 0.2338
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0012 0.0063 0.0094
Loa Loa (eye worm) hypothetical protein 0.0135 0.1781 0.4864
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0012 0.0063 0.0113
Echinococcus multilocularis fibrillin 1 0.0014 0.0084 0.0046
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0381 0.0991
Schistosoma mansoni glutaminase 0.0267 0.364 0.3626
Echinococcus granulosus Tolloid protein 1 0.0014 0.0084 0.0046
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0039 0.0048
Loa Loa (eye worm) hypothetical protein 0.0034 0.0372 0.0968
Brugia malayi PAN domain containing protein 0.0034 0.0372 0.0965
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0301 0.0667
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0505 0.3732
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0118 0.0079
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.091 0.2373
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0039 0.0044
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0148 0.0366
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0187
Brugia malayi glutathione reductase 0.0037 0.041 0.1069
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.018 0.2426 0.5531
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.091 0.2373
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0012 0.0061 0.0022
Onchocerca volvulus 0.0014 0.009 0.0288
Schistosoma mansoni hypothetical protein 0.0014 0.009 0.0068
Echinococcus multilocularis transmembrane protease serine 3 0.0014 0.009 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0039 0.0048
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0039 0.0017
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0148 0.0109
Echinococcus multilocularis glycoprotein Antigen 5 0.0014 0.009 0.0051
Brugia malayi PAN domain containing protein 0.0034 0.0372 0.0965
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.125 0.3323
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.033
Brugia malayi glutaminase DH11.1 0.0267 0.364 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0149 0.0348
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0189 0.0357
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0071 0.0041
Trypanosoma brucei pteridine reductase 1 0.0012 0.0063 0.0013
Toxoplasma gondii microneme protein MIC17B 0.0034 0.0372 0.0806
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0156 0.1244
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0156 0.0117
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0014 0.009 0.0051
Plasmodium falciparum cysteine repeat modular protein 1 0.0053 0.0635 0.2427
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.009 0.0068
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0156 0.0264
Brugia malayi nuclear hormone receptor 0.0011 0.0039 0.0044
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0189 0.0357
Echinococcus multilocularis enteropeptidase 0.0014 0.009 0.0051
Onchocerca volvulus 0.0029 0.0301 0.1492
Brugia malayi Troponin T 0.0065 0.0803 0.2156
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.01 0.1289 0.5188
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.091 0.2373
Brugia malayi AMP-binding enzyme family protein 0.01 0.1289 0.35
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0173
Schistosoma mansoni phospholipase C beta 0.0018 0.0143 0.0121
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.009 0.0068
Echinococcus multilocularis tissue type plasminogen activator 0.0053 0.0635 0.0598
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0053 0.0635 0.2566
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0149 0.0245
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0039 0.0044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0878 0.3452
Trypanosoma brucei polo-like protein kinase 0.0097 0.125 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0301 0.0667
Toxoplasma gondii ck2 beta subunit 0.0073 0.091 0.2044
Onchocerca volvulus 0.0034 0.0372 0.1894
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0021 0.0189 0.1351
Loa Loa (eye worm) hypothetical protein 0.0043 0.0488 0.129
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0301 0.101
Echinococcus granulosus casein kinase ii subunit beta 0.0073 0.091 0.0875
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.125 0.6889
Schistosoma mansoni hypothetical protein 0.0109 0.1428 0.1409
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.125 0.9697
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0173 0.2325 0.2295
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0301 0.0667
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.125 0.9701
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.125 0.3323
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0222 0.0183
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0244 0.0769
Loa Loa (eye worm) hypothetical protein 0.0208 0.2815 0.7721
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0322 0.2578
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0071 0.0224
Loa Loa (eye worm) hypothetical protein 0.0074 0.0928 0.2505
Toxoplasma gondii hypothetical protein 0.0034 0.0372 0.0806
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0061 0.0039
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0009 0.0022 0.0174
Giardia lamblia Kinase, PLK 0.0097 0.125 1
Schistosoma mansoni hypothetical protein 0.0053 0.0635 0.0615
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.091 0.2373
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0039 0.0017
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0012 0.0063 0.0006
Loa Loa (eye worm) oxidoreductase 0.0029 0.0301 0.0773
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0073 0.091 0.7024
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0029 0.0301 0.101
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0048
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.009 0.0068
Onchocerca volvulus 0.0034 0.0372 0.1894
Onchocerca volvulus 0.0012 0.0063 0.0134
Brugia malayi PAN domain containing protein 0.0034 0.0372 0.0965
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0029 0.0301 0.0667
Echinococcus multilocularis bloom syndrome protein 0.0044 0.0513 0.0476
Toxoplasma gondii calcium binding egf domain-containing protein 0.0014 0.0084 0.0144
Echinococcus granulosus bloom syndrome protein 0.0044 0.0513 0.0476
Brugia malayi hypothetical protein 0.0065 0.0803 0.2156
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0014 0.0084 0.0173
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0156 0.0117
Treponema pallidum NADH oxidase 0.0013 0.0071 0.385
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0878 0.3452
Leishmania major oxidoreductase-like protein 0.0012 0.0063 0.0485
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.009 0.0068
Echinococcus granulosus oncosphere protein Tso22e 0.0136 0.1797 0.1765
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.125 0.1231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0039 0.0048
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0301 0.0671
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0012 0.0063 0.0024
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0029 0.0301 0.101
Brugia malayi Trypsin family protein 0.0014 0.009 0.0184
Onchocerca volvulus 0.0014 0.009 0.0288
Toxoplasma gondii thioredoxin reductase 0.0037 0.041 0.0892
Echinococcus multilocularis laminin 0.0014 0.0084 0.0046
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0039 0.0017
Trichomonas vaginalis hypothetical protein 0.018 0.2426 0.6609
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0012 0.0063 0.036
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.1206 0.4839
Loa Loa (eye worm) hypothetical protein 0.0019 0.0158 0.0376
Schistosoma mansoni DNA helicase recq1 0.0018 0.0148 0.0126
Loa Loa (eye worm) glutathione reductase 0.0037 0.041 0.1072
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0766 0.073
Schistosoma mansoni zinc finger protein 0.002 0.0178 0.0157
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0118 0.0263
Brugia malayi Bromodomain containing protein 0.004 0.0453 0.1188
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0029 0.0301 0.101
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0039 0.0044
Brugia malayi PAN domain containing protein 0.0034 0.0372 0.0965
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0073 0.0104
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.091 0.2373
Leishmania major pteridine reductase 1 0.0012 0.0063 0.0485
Brugia malayi Calcium binding EGF domain containing protein 0.0014 0.0084 0.017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0149 0.119
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0141 0.0102
Brugia malayi ecdysteroid receptor 0.0011 0.0039 0.0044
Echinococcus granulosus glycoprotein Antigen 5 0.0014 0.009 0.0051
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0131 0.1731 0.4726
Brugia malayi PAN domain containing protein 0.0034 0.0372 0.0965
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0021 0.0189 0.1351
Leishmania major 4-coumarate:coa ligase-like protein 0.01 0.1289 1
Plasmodium vivax casein kinase II beta chain, putative 0.0073 0.091 0.3709
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0301 0.101
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0189 0.0357
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.01 0.1289 0.3428
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0012 0.0063 0.019
Plasmodium falciparum glutathione reductase 0.0013 0.0071 0.0041
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0149 0.1154
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0009 0.0022 0.0174
Trypanosoma cruzi ISWI complex protein 0.0016 0.0115 0.0922
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0012 0.0063 0.0013
Loa Loa (eye worm) hypothetical protein 0.0109 0.1428 0.3886
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0149 0.0351
Trypanosoma brucei oxidoreductase-like protein 0.0012 0.0063 0.0013
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0156 0.0795
Schistosoma mansoni hypothetical protein 0.0014 0.009 0.0068
Loa Loa (eye worm) glutaminase 2 0.0267 0.364 1
Schistosoma mansoni hypothetical protein 0.0016 0.0118 0.0096
Toxoplasma gondii PAN domain-containing protein 0.0319 0.4369 1
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0372 0.0806
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0141 0.012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0048
Trichomonas vaginalis casein kinase II beta chain, putative 0.0073 0.091 0.2373
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0301 0.077
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0014 0.009 0.0051
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0148 0.0345
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0071 0.0081
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0071 0.0027
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0189 0.0357
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0222 0.02
Loa Loa (eye worm) hypothetical protein 0.0074 0.0935 0.2526
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0173 0.2325 0.2295
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0301 0.0667
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0148 0.0109
Mycobacterium ulcerans fatty-acid-CoA ligase 0.01 0.1289 0.3428
Loa Loa (eye worm) hypothetical protein 0.0053 0.0635 0.1695
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0136 0.1797 0.1765
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0039 0.0044
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0071 0.0081
Schistosoma mansoni hypothetical protein 0.0016 0.0118 0.0096
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0189 0.0357
Brugia malayi AMP-binding enzyme family protein 0.01 0.1289 0.35
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0156 0.037
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0029 0.0301 0.0667
Plasmodium vivax acyl-CoA synthetase, putative 0.0074 0.0935 0.3813

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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