Detailed information for compound 770321

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 344.878 | Formula: C20H25ClN2O
  • H donors: 1 H acceptors: 1 LogP: 3.43 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCC1CN(CCN1Cc1ccccc1)Cc1ccc(cc1)Cl
  • InChi: 1S/C20H25ClN2O/c21-19-8-6-18(7-9-19)14-22-11-12-23(20(16-22)10-13-24)15-17-4-2-1-3-5-17/h1-9,20,24H,10-16H2
  • InChiKey: JBMAJQCCIAXNJV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0265 0.0301
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.0505 0.5778
Echinococcus multilocularis hexokinase 0.0089 0.0864 0.0855
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0103 0.0544
Echinococcus granulosus hexokinase 0.0089 0.0864 0.1007
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1739 0.4941
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0479 0.1199
Echinococcus multilocularis dna polymerase eta 0.0069 0.0641 0.0631
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0033 0.0217
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0479 0.0469
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0057 0.0047
Schistosoma mansoni zinc finger protein 0.0015 0.0037 0.0033
Echinococcus multilocularis peregrin 0.0035 0.0259 0.0249
Echinococcus granulosus expressed conserved protein 0.0091 0.0883 0.103
Schistosoma mansoni flap endonuclease-1 0.0026 0.0163 0.018
Toxoplasma gondii hexokinase 0.0089 0.0864 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0359 0.4052
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0033 0.0217
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.0505 0.0496
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0405 0.0465
Echinococcus multilocularis short transient receptor potential channel 6 0.0071 0.0666 0.0657
Loa Loa (eye worm) hexokinase 0.0028 0.0176 0.0419
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0359 0.4052
Mycobacterium tuberculosis Conserved protein 0.004 0.0316 0.1017
Echinococcus granulosus flap endonuclease 1 0.0029 0.0194 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0033 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0133 0.0377
Leishmania major hexokinase, putative 0.0089 0.0864 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0339 0.3816
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.0505 0.0584
Onchocerca volvulus 0.004 0.0316 0.0579
Echinococcus multilocularis protein quaking 0.003 0.0208 0.0199
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.0339 0.0329
Brugia malayi N-terminal motif family protein 0.0201 0.2111 0.5414
Mycobacterium ulcerans lipase LipD 0.004 0.0316 0.1839
Echinococcus multilocularis transient receptor potential ion channel A 0.0104 0.1034 0.1025
Toxoplasma gondii exonuclease III APE 0.0021 0.0103 0.1049
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0183 0.2037
Brugia malayi Bromodomain containing protein 0.0076 0.0717 0.1815
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.0339 0.0388
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0103 0.023
Schistosoma mansoni hypothetical protein 0.0067 0.0619 0.0718
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0133 0.0377
Brugia malayi Bromodomain containing protein 0.0035 0.0259 0.0631
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0033 0.0217
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0405 0.0465
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0194 0.0265
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0194 0.2159
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0194 0.0512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0359 0.1019
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1412 0.1654
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0194 0.2113
Schistosoma mansoni transient receptor potential channel 0.0071 0.0666 0.0774
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.352 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0316 0.0361
Schistosoma mansoni hypothetical protein 0.0067 0.0619 0.0718
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0194 0.2113
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.0505 0.0584
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0233 0.0662
Echinococcus multilocularis TRP (transient receptor potential) channel 0.004 0.0317 0.0307
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0027
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0405 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0359 0.1019
Brugia malayi Hexokinase family protein 0.0056 0.0493 0.1236
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0962 0.1123
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0183 0.2037
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.0505 0.5778
Schistosoma mansoni cpg binding protein 0.0032 0.0227 0.0257
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0621 0.1566
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0949 0.1107
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0103 0.1101
Schistosoma mansoni cpg binding protein 0.0036 0.0269 0.0306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0287 0.0815
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0033 0.0027
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0316 0.0897
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0619 0.1561
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0548 0.0635
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0259 0.2876
Treponema pallidum fructose-bisphosphate aldolase 0.0327 0.352 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0158 0.045
Brugia malayi intermediate filament protein 0.003 0.0205 0.0493
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0309 0.03
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0037 0.0287 0.3211
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0339 0.3816
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0187 0.053
Onchocerca volvulus Huntingtin homolog 0.0137 0.1399 0.6266
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0505 0.5778
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.0505 0.1267
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0014 0.0058
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0317 0.3557
Echinococcus multilocularis geminin 0.0363 0.392 0.3915
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.0778
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0096 0.0212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.01 0.1011
Onchocerca volvulus 0.0048 0.0405 0.1045
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0962 0.2448
Brugia malayi hypothetical protein 0.0018 0.0072 0.0148
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0259 0.2876
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0103 0.0294
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0339 0.3816
Schistosoma mansoni hypothetical protein 0.0067 0.0619 0.0718
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0014 0.0005
Brugia malayi PHD-finger family protein 0.0014 0.0029 0.0038
Onchocerca volvulus 0.0089 0.0864 0.3455
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.0028 0.0021
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0316 0.1017
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0505 0.1435
Brugia malayi Muscleblind-like protein 0.0167 0.1735 0.4443
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.1739 0.8051
Leishmania major hypothetical protein, conserved 0.0028 0.0183 0.1991
Schistosoma mansoni patched 1 0.0042 0.0332 0.038
Echinococcus multilocularis short transient receptor potential channel 6 0.0071 0.0666 0.0657
Loa Loa (eye worm) hypothetical protein 0.0097 0.0949 0.2413
Brugia malayi hexokinase 0.0089 0.0864 0.2193
Plasmodium falciparum phd finger protein, putative 0.0033 0.0233 0.2614
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0103 0.0111
Leishmania major DNA polymerase eta, putative 0.0069 0.0641 0.7374
Loa Loa (eye worm) hypothetical protein 0.0167 0.1735 0.4443
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0043 0.0336
Brugia malayi hypothetical protein 0.0028 0.0183 0.0437
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0962 0.1123
Loa Loa (eye worm) hypothetical protein 0.0033 0.0233 0.0564
Echinococcus multilocularis zinc finger protein 0.0021 0.0105 0.0095
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0065 0.0055
Loa Loa (eye worm) intermediate filament protein 0.003 0.0205 0.0493
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0183 0.1991
Brugia malayi Flap endonuclease-1 0.0029 0.0194 0.0464
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0057 0.0055
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0316 0.0361
Loa Loa (eye worm) MBCTL1 0.0055 0.0479 0.1199
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0316 0.1017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0258 0.0734
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0031 0.0025
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0962 0.2448
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0339 0.0329
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1739 0.4941
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0332 0.0943
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0255 0.272 0.6987
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0405 0.1045
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0339 0.1979
Entamoeba histolytica deoxycytidyl transferase, putative 0.0042 0.0339 0.0688
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.272 0.7726
Echinococcus multilocularis microtubule associated protein 2 0.0772 0.849 0.8489
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.0505 0.5778
Loa Loa (eye worm) hypothetical protein 0.0167 0.1735 0.4443
Schistosoma mansoni tar DNA-binding protein 0.007 0.0655 0.0761
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0183 0.1991
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0161 0.0458
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0033 0.0217
Brugia malayi latrophilin 2 splice variant baaae 0.0145 0.1489 0.3809
Brugia malayi tumor suppressor. 0.036 0.3886 1
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0316 0.1839
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0233 0.2614
Schistosoma mansoni lamin 0.003 0.0205 0.0231
Loa Loa (eye worm) hypothetical protein 0.0037 0.0277 0.0677
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.0505 0.5778
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0962 0.1123
Echinococcus granulosus protein quaking 0.003 0.0208 0.0234
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.0778
Echinococcus granulosus peregrin 0.0035 0.0259 0.0294
Schistosoma mansoni hypothetical protein 0.003 0.0208 0.0234
Schistosoma mansoni hypothetical protein 0.003 0.0208 0.0234
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0233 0.0263
Schistosoma mansoni hypothetical protein 0.0363 0.392 0.4611
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0033 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0316 0.3548
Echinococcus granulosus hexokinase type 2 0.0089 0.0864 0.1007
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0316 0.0897
Entamoeba histolytica hypothetical protein 0.0035 0.0263 0.0468
Schistosoma mansoni zinc finger protein 0.0021 0.0105 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0133 0.0378
Onchocerca volvulus Alhambra homolog 0.0033 0.0233 0.0143
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0043 0.0336
Loa Loa (eye worm) hypothetical protein 0.0053 0.0455 0.1138
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0339 0.0837
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0287 0.0815
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0316 0.3548
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0043 0.0039
Schistosoma mansoni tar DNA-binding protein 0.007 0.0655 0.0761
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0339 0.1102
Echinococcus granulosus lamin 0.003 0.0205 0.0231
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0327 0.352 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0033 0.0093
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0359 0.0411
Echinococcus granulosus hypothetical protein 0.003 0.0208 0.0234
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0505 0.1435
Echinococcus granulosus short transient receptor potential channel 6 0.0071 0.0666 0.0774
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0043
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0138 0.0128
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0043 0.0033
Trypanosoma cruzi hexokinase, putative 0.0089 0.0864 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.0028 0.0018
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.0505 0.14
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0287 0.325
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.0339 0.0388
Schistosoma mansoni tar DNA-binding protein 0.007 0.0655 0.0761
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0619 0.0718
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0359 0.0349
Schistosoma mansoni hypothetical protein 0.004 0.0315 0.036
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0033 0.0217
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0072 0.0679
Trypanosoma brucei unspecified product 0.0042 0.0339 0.3816
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0212 0.2239 0.5746
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0316 0.1017
Schistosoma mansoni transient receptor potential channel 4 0.0108 0.1074 0.1255
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0183 0.1991
Echinococcus granulosus tar DNA binding protein 0.007 0.0655 0.0761
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0359 0.0889
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.352 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0359 0.1019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0339 0.3816
Schistosoma mansoni transient receptor potential channel 0.0071 0.0666 0.0774
Echinococcus multilocularis musashi 0.003 0.0205 0.0196
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0043 0.0074
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0205 0.0493
Loa Loa (eye worm) hypothetical protein 0.0145 0.1489 0.3809
Schistosoma mansoni tar DNA-binding protein 0.007 0.0655 0.0761
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0332 0.038
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1739 0.4941
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.2028 0.238
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.0778
Loa Loa (eye worm) hypothetical protein 0.003 0.0209 0.0501
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0655 0.1655
Echinococcus granulosus zinc finger protein 0.0021 0.0105 0.0112
Brugia malayi hypothetical protein 0.003 0.0209 0.0501
Echinococcus granulosus cpg binding protein 0.0036 0.0269 0.0306
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0351 0.0869
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0479 0.0553
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1412 0.1404
Brugia malayi beta-lactamase family protein 0.004 0.0316 0.0778
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0339 0.3816
Brugia malayi CXXC zinc finger family protein 0.0032 0.0227 0.055
Brugia malayi TAR-binding protein 0.007 0.0655 0.1655
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0033 0.0217
Plasmodium falciparum flap endonuclease 1 0.0029 0.0194 0.2159
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0339 0.3816
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.272 0.7726
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1739 0.4941
Echinococcus multilocularis cpg binding protein 0.0036 0.0269 0.0259
Trypanosoma brucei hexokinase 0.0089 0.0864 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.117 0.2985
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0043 0.0074
Brugia malayi Calcitonin receptor-like protein seb-1 0.0212 0.2239 0.5746
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0949 0.094
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0405 0.0465
Trypanosoma brucei hexokinase, putative 0.0089 0.0864 1
Trypanosoma brucei hexokinase 0.0089 0.0864 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0193 0.2099
Loa Loa (eye worm) hypothetical protein 0.0042 0.0332 0.082
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.1062 0.1053
Giardia lamblia DINP protein human, muc B family 0.0042 0.0339 0.0925
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0332 0.038
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0405 0.0465
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0263 0.0254
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0037 0.0287 0.0327
Schistosoma mansoni lamin 0.003 0.0205 0.0231
Onchocerca volvulus 0.004 0.0316 0.0579
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1739 0.4941
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0359 0.0411
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0043 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0161 0.0458
Brugia malayi CHE-14 protein 0.0042 0.0332 0.082
Schistosoma mansoni hypothetical protein 0.004 0.0315 0.036
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0043 0.0392
Brugia malayi jmjC domain containing protein 0.0043 0.0351 0.0869
Entamoeba histolytica hypothetical protein 0.0035 0.0263 0.0468
Onchocerca volvulus 0.0032 0.0227 0.0115
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0359 0.0746
Mycobacterium tuberculosis Conserved protein 0.004 0.0316 0.1017
Trypanosoma cruzi ISWI complex protein 0.0015 0.0037 0.0271
Brugia malayi PHD-finger family protein 0.0033 0.0233 0.0564
Entamoeba histolytica hypothetical protein 0.0035 0.0263 0.0468
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0194 0.2113
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0233 0.2571
Giardia lamblia GTOR 0.0044 0.0359 0.0982
Mycobacterium ulcerans beta-lactamase 0.004 0.0316 0.1839
Trypanosoma brucei protein kinase, putative 0.0057 0.0505 0.5778
Echinococcus granulosus dna polymerase eta 0.0069 0.0641 0.0744
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0505 0.0584
Echinococcus multilocularis lamin dm0 0.003 0.0205 0.0196
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0194 0.0464
Schistosoma mansoni DNA polymerase eta 0.0069 0.0641 0.0744
Trypanosoma brucei DNA polymerase eta, putative 0.0069 0.0641 0.7374
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.272 0.7726
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0233 0.0662
Trypanosoma brucei ISWI complex protein 0.0015 0.0037 0.0271
Loa Loa (eye worm) hypothetical protein 0.004 0.0317 0.0781
Brugia malayi isocitrate dehydrogenase 0.0016 0.0043 0.0074
Echinococcus granulosus hexokinase 0.0089 0.0864 0.1007
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0351 0.0402
Schistosoma mansoni hypothetical protein 0.0035 0.0263 0.0299
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0043 0.0033
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.0778
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0619 0.0609
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0505 0.1435
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0375 0.0366
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0316 0.0897
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0233 0.2574
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.0505 0.5778
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0033 0.0093
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0339 0.1979
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0037 0.0287 0.0704
Mycobacterium tuberculosis Conserved protein 0.004 0.0316 0.1017
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0287 0.0704
Plasmodium vivax hypothetical protein, conserved 0.004 0.0316 0.3585
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0037 0.0287 0.0704
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0949 0.2474
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0233 0.0564
Echinococcus multilocularis hexokinase type 2 0.0089 0.0864 0.0855
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0263 0.0299
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.0778
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0233 0.0263
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0505 0.5778
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0962 0.0953
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.272 0.7726
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0014 0.0058
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0065 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0339 0.3816
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0227 0.055
Echinococcus multilocularis tar DNA binding protein 0.007 0.0655 0.0646
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0619 0.0718
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0033 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0197 0.056
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.117 0.2985
Loa Loa (eye worm) hypothetical protein 0.0061 0.0547 0.1376
Brugia malayi hypothetical protein 0.0035 0.0263 0.0643
Schistosoma mansoni cpg binding protein 0.0036 0.0269 0.0306
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0043 0.0033
Echinococcus granulosus microtubule associated protein 2 0.0772 0.849 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.004 0.0315 0.036
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.184 0.5227
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0033 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0193 0.2099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.352 1
Plasmodium vivax hexokinase, putative 0.0089 0.0864 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0339 0.1102
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0359 0.4052
Loa Loa (eye worm) beta-lactamase 0.004 0.0316 0.0778
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0287 0.325
Loa Loa (eye worm) hypothetical protein 0.007 0.0649 0.164
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0037 0.0287 0.0537
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0405 0.0395
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0043 0.0336
Loa Loa (eye worm) hypothetical protein 0.0055 0.0479 0.1199
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0205 0.0493
Loa Loa (eye worm) hexokinase type II 0.0089 0.0864 0.2193
Brugia malayi hexokinase type II 0.0028 0.0185 0.044
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0505 0.1435
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0332 0.0323
Echinococcus multilocularis protein dispatched 1 0.0047 0.0398 0.0388
Leishmania major DNA polymerase kappa, putative 0.0042 0.0339 0.3816
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0103 0.023
Echinococcus granulosus geminin 0.0363 0.392 0.4611
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0479 0.0553
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0161 0.0458
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0256 0.2725 1
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0316 0.1017
Toxoplasma gondii ImpB/MucB/SamB family protein 0.004 0.0317 0.3557
Brugia malayi Temporarily assigned gene name protein 44 0.003 0.0209 0.0501
Loa Loa (eye worm) hypothetical protein 0.0068 0.0626 0.1579
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0375 0.0431
Echinococcus granulosus hexokinase 0.0089 0.0864 0.1007
Schistosoma mansoni ap endonuclease 0.0021 0.0103 0.0111
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0619 0.0609
Loa Loa (eye worm) hypothetical protein 0.0137 0.1399 0.3576
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0201 0.2111 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.016 0.1652 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0359 0.0746
Onchocerca volvulus Hexokinase homolog 0.0056 0.0493 0.1508
Echinococcus granulosus dna polymerase kappa 0.0042 0.0339 0.0388
Brugia malayi RNA binding protein 0.007 0.0655 0.1655
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0962 0.1123
Schistosoma mansoni hypothetical protein 0.0363 0.392 0.4611
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.352 1
Echinococcus granulosus transient receptor potential ion channel A 0.0104 0.1034 0.1208
Echinococcus granulosus lamin dm0 0.003 0.0205 0.0231
Echinococcus granulosus GPCR family 2 0.0067 0.0619 0.0718
Schistosoma mansoni transient receptor potential channel 0.0108 0.1074 0.1255
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0043 0.0039
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0332 0.082
Loa Loa (eye worm) hypothetical protein 0.0056 0.0493 0.1236
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0405 0.0465
Loa Loa (eye worm) hypothetical protein 0.0212 0.2239 0.5746
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0574 0.6595
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0183 0.1991
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0339 0.3816
Brugia malayi Hexokinase family protein 0.0089 0.0864 0.2193
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0043 0.0392
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0316 0.0897
Loa Loa (eye worm) hexokinase 0.0089 0.0864 0.2193
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0212 0.2239 0.5746
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0816 0.0951
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0287 0.3211
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0359 0.0889
Echinococcus multilocularis protein patched 0.0042 0.0332 0.0323
Brugia malayi hypothetical protein 0.0137 0.1399 0.3576
Giardia lamblia PHD finger protein 15 0.0033 0.0233 0.0623
Trypanosoma brucei unspecified product 0.0029 0.0193 0.2099
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0316 0.1017
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1739 0.4941
Schistosoma mansoni microtubule-associated protein tau 0.0772 0.849 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0263 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0258 0.0734
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0103 0.1049
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0339 0.0962
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0479 0.0469
Leishmania major DNA polymerase eta, putative 0.004 0.0317 0.3557
Schistosoma mansoni hypothetical protein 0.0067 0.0619 0.0718
Echinococcus multilocularis tumor protein p63 0.0359 0.3876 0.387
Brugia malayi mbt repeat family protein 0.0048 0.0405 0.1008
Echinococcus multilocularis hexokinase 0.0089 0.0864 0.0855
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.352 1
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0351 0.0402
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0194 0.0551
Echinococcus granulosus intermediate filament protein 0.003 0.0205 0.0231
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0138 0.0151
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.352 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0359 0.4052
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.184 0.5227
Echinococcus multilocularis hexokinase 0.0089 0.0864 0.0855
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0057 0.0055
Echinococcus multilocularis expressed conserved protein 0.0091 0.0883 0.0874
Loa Loa (eye worm) hypothetical protein 0.004 0.0318 0.0785
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0027
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0339 0.3816
Mycobacterium ulcerans hypothetical protein 0.004 0.0316 0.1839
Brugia malayi Transient-receptor-potential like protein 0.004 0.0317 0.0781
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0133 0.0378
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0064 0.0127
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0103 0.0294
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0077 0.0079
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.013
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.0505 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0033 0.0093
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0103 0.1049
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0103 0.0226
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0455 0.0525
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0339 0.3816
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0037 0.0287 0.3211
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0043 0.0033
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0037 0.0287 0.0278
Echinococcus granulosus TRP transient receptor potential channel 0.004 0.0317 0.0362
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0316 0.0306
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0339 0.3816
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0339 0.3816
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0287 0.0815
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0962 0.0953
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0962 0.1123
Schistosoma mansoni hexokinase 0.0089 0.0864 0.1007
Trypanosoma cruzi hexokinase, putative 0.0089 0.0864 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0479 0.0553
Loa Loa (eye worm) hypothetical protein 0.0028 0.0185 0.044
Loa Loa (eye worm) hypothetical protein 0.0028 0.0183 0.0437
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.272 0.7726
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0233 0.0662
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0316 0.1839
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0057 0.0055
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.2028 0.202
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0037 0.0287 0.3211
Loa Loa (eye worm) hypothetical protein 0.0038 0.0292 0.0717
Leishmania major hypothetical protein, conserved 0.0015 0.0037 0.0271
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0031 0.0021
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0118 0.0268
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.016 0.1652 0.6
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0265 0.0256
Entamoeba histolytica hexokinase 2 0.0089 0.0864 0.2225
Echinococcus granulosus dnaJ subfamily B 0.0455 0.4949 0.5824
Onchocerca volvulus 0.0053 0.0455 0.131
Loa Loa (eye worm) hypothetical protein 0.003 0.0199 0.0478
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0193 0.2099
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0049 0.0089
Schistosoma mansoni hypothetical protein 0.0455 0.4949 0.5824
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0259 0.2876
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.272 0.7726
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0233 0.0662
Brugia malayi Hexokinase family protein 0.0028 0.0176 0.0419
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0233 0.2571
Schistosoma mansoni hypothetical protein 0.0015 0.0037 0.0033
Echinococcus granulosus muscleblind protein 0.0167 0.1735 0.2034
Onchocerca volvulus 0.0089 0.0864 0.3455
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0316 0.0778
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0316 0.0778
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.0339 0.0837
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0949 0.2413
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0287 0.3211
Brugia malayi beta-lactamase family protein 0.004 0.0316 0.0778
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0183 0.2037
Echinococcus multilocularis muscleblind protein 0.0167 0.1735 0.1727
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0043 0.0336
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0619 0.1561
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.352 1
Echinococcus multilocularis lamin 0.003 0.0205 0.0196
Schistosoma mansoni hypothetical protein 0.0145 0.1489 0.1744
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0339 0.3816
Giardia lamblia Fructose-bisphosphate aldolase 0.0327 0.352 1
Entamoeba histolytica hexokinase 1 0.0089 0.0864 0.2225
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0316 0.1017
Brugia malayi beta-lactamase 0.004 0.0316 0.0778
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0038
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0043 0.0336
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0103 0.1049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0233 0.0662
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0339 0.3816
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0327 0.352 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0185 0.044
Onchocerca volvulus 0.0056 0.0493 0.1508
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0138 0.0151
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0103 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0339 0.3816
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0339 0.3816
Loa Loa (eye worm) hypothetical protein 0.0137 0.1399 0.3576
Schistosoma mansoni hypothetical protein 0.0296 0.3174 0.3732
Loa Loa (eye worm) TAR-binding protein 0.007 0.0655 0.1655
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0103 0.0094
Entamoeba histolytica hypothetical protein 0.0035 0.0263 0.0468
Brugia malayi PHD-finger family protein 0.0026 0.0164 0.0386
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1739 0.4941
Leishmania major hypothetical protein, conserved 0.004 0.0316 0.3548
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0359 0.4052
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0255 0.272 0.6987
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0043 0.0336
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0194 0.0184
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0043 0.0336
Schistosoma mansoni hypothetical protein 0.0033 0.0233 0.0263
Schistosoma mansoni tar DNA-binding protein 0.007 0.0655 0.0761
Loa Loa (eye worm) hypothetical protein 0.0051 0.0436 0.109
Trypanosoma cruzi ISWI complex protein 0.0015 0.0037 0.0271
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.0505 0.5778
Trypanosoma brucei unspecified product 0.0029 0.0193 0.2099
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0316 0.0897
Loa Loa (eye worm) hexokinase 0.0056 0.0493 0.1236
Trypanosoma cruzi DNA polymerase eta, putative 0.0069 0.0641 0.7374
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0037 0.0287 0.0327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0258 0.0734
Loa Loa (eye worm) hypothetical protein 0.003 0.0205 0.0493
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0965 0.1127
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0316 0.0361
Loa Loa (eye worm) tumor suppressor 0.036 0.3886 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0339 0.3816
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0316 0.3548
Brugia malayi MH2 domain containing protein 0.0117 0.117 0.2985
Onchocerca volvulus Huntingtin homolog 0.0137 0.1399 0.6266
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0339 0.0962
Echinococcus multilocularis transient receptor potential gamma protein 0.0108 0.1074 0.1065
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.352 1
Loa Loa (eye worm) hypothetical protein 0.0201 0.2111 0.5414
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.1062 0.124
Onchocerca volvulus 0.0089 0.0864 0.3455
Brugia malayi MAP kinase sur-1 0.0057 0.0505 0.1267
Schistosoma mansoni hypothetical protein 0.004 0.0315 0.036
Trichomonas vaginalis esterase, putative 0.004 0.0316 0.0897
Plasmodium falciparum hexokinase 0.0089 0.0864 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.036 0.0892
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.0339 0.0388
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0655 0.1655
Brugia malayi jmjC domain containing protein 0.0107 0.1062 0.2704
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0233 0.0223
Loa Loa (eye worm) hypothetical protein 0.0067 0.0619 0.1561
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0548 0.0539
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0069 0.0641 0.1617
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0339 0.3816
Schistosoma mansoni bromodomain containing protein 0.0064 0.0588 0.0681
Loa Loa (eye worm) hypothetical protein 0.0048 0.0405 0.1008
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0405 0.1008
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0103 0.1101
Onchocerca volvulus 0.004 0.0316 0.0579
Leishmania major hexokinase, putative 0.0089 0.0864 1
Treponema pallidum hexokinase (hxk) 0.0089 0.0864 0.2225
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.0778
Echinococcus granulosus transient receptor potential gamma protein 0.0108 0.1074 0.1255
Echinococcus multilocularis GPCR, family 2 0.0067 0.0619 0.0609
Loa Loa (eye worm) hexokinase 0.0089 0.0864 0.2193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0033 0.0093
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0351 0.0402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0258 0.0734
Brugia malayi mbt repeat family protein 0.0048 0.0405 0.1008
Brugia malayi Bromodomain containing protein 0.0038 0.0291 0.0715
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0033 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0233 0.0662
Loa Loa (eye worm) hypothetical protein 0.0108 0.1074 0.2737
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0233 0.0662
Echinococcus multilocularis dnaJ subfamily B 0.0455 0.4949 0.4944
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0359 0.4052
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0194 0.2113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0133 0.0378
Schistosoma mansoni ap endonuclease 0.0021 0.0103 0.0111
Schistosoma mansoni hypothetical protein 0.002 0.0096 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0158 0.045
Echinococcus granulosus short transient receptor potential channel 6 0.0071 0.0666 0.0774
Echinococcus granulosus tumor protein p63 0.0359 0.3876 0.4559
Schistosoma mansoni intermediate filament proteins 0.003 0.0205 0.0231
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.063 0.0731
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0103 0.1049
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0049 0.0089
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.016 0.1652 1
Echinococcus multilocularis muscleblind protein 1 0.0167 0.1735 0.1727
Loa Loa (eye worm) RNA binding protein 0.007 0.0655 0.1655
Brugia malayi ImpB/MucB/SamB family protein 0.0069 0.0641 0.1617
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0316 0.1017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0133 0.0378
Toxoplasma gondii ABC1 family protein 0.004 0.0316 0.3548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0258 0.0734
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0103 0.0254
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0287 0.0704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0133 0.0377
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0619 0.1561

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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