Detailed information for compound 844731

Basic information

Technical information
  • TDR Targets ID: 844731
  • Name: 2-(4-methylpiperidin-1-yl)-N-(3-propan-2-ylox ypropyl)-1,3-benzothiazole-6-carboxamide
  • MW: 375.528 | Formula: C20H29N3O2S
  • H donors: 1 H acceptors: 2 LogP: 4.4 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCN(CC1)c1nc2c(s1)cc(cc2)C(=O)NCCCOC(C)C
  • InChi: 1S/C20H29N3O2S/c1-14(2)25-12-4-9-21-19(24)16-5-6-17-18(13-16)26-20(22-17)23-10-7-15(3)8-11-23/h5-6,13-15H,4,7-12H2,1-3H3,(H,21,24)
  • InChiKey: RVMCDPLMTLMHIT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-isopropoxypropyl)-2-(4-methyl-1-piperidyl)-1,3-benzothiazole-6-carboxamide
  • N-(3-isopropoxypropyl)-2-(4-methyl-1-piperidinyl)-1,3-benzothiazole-6-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0322 0.0753
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0004 0.0033 0.0037
Echinococcus multilocularis survival motor neuron protein 1 0.0213 0.5427 0.6047
Mycobacterium ulcerans aldehyde dehydrogenase 0.0029 0.0674 0.1572
Echinococcus multilocularis rhodopsin orphan GPCR 0.0141 0.3555 0.3961
Brugia malayi regulator of G-protein signaling egl-10 0.0004 0.0033 0.0061
Schistosoma mansoni aldehyde dehydrogenase 0.0029 0.0674 0.0751
Mycobacterium ulcerans acyl-CoA synthetase 0.0011 0.0202 0.0468
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0141 0.3555 0.3961
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0004 0.0033 0.0037
Echinococcus granulosus biogenic amine 5HT receptor 0.0141 0.3555 0.3961
Loa Loa (eye worm) hypothetical protein 0.0029 0.0677 0.1248
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0322 0.0753
Onchocerca volvulus Protein ultraspiracle homolog 0.0004 0.0033 0.0093
Loa Loa (eye worm) hypothetical protein 0.0061 0.1496 0.2757
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0004 0.0033 0.0061
Brugia malayi sulfakinin receptor protein 0.0141 0.3555 0.6551
Echinococcus granulosus rhodopsin orphan GPCR 0.0141 0.3555 0.3961
Toxoplasma gondii PAN/Apple domain-containing protein 0.0006 0.0086 0.0334
Echinococcus multilocularis sex peptide receptor 0.0141 0.3555 0.3961
Brugia malayi beta-lactamase family protein 0.0061 0.1496 0.2757
Brugia malayi AMP-binding enzyme family protein 0.0011 0.0202 0.0372
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0003 0.0001 0.001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0141 0.3555 0.3961
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0137 0.0908
Brugia malayi hypothetical protein 0.0213 0.5427 1
Leishmania major DNA polymerase eta, putative 0.002 0.0426 0.2841
Toxoplasma gondii PAN domain-containing protein 0.01 0.2518 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0141 0.3555 0.3961
Trypanosoma brucei DNA polymerase IV, putative 0.0008 0.0137 0.0908
Loa Loa (eye worm) neuropeptide F receptor 0.0141 0.3555 0.6551
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.1003 0.2343
Leishmania major DNA polymerase eta, putative 0.0014 0.0275 0.1831
Mycobacterium ulcerans hypothetical protein 0.0011 0.0202 0.0468
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0004 0.0033 0.0061
Echinococcus granulosus TGF beta signal transducer SmadC 0.0004 0.0011 0.0012
Brugia malayi ecdysteroid receptor 0.0004 0.0033 0.0061
Echinococcus multilocularis polycomb protein SCMH1 0.0029 0.0677 0.0755
Trypanosoma cruzi DNA polymerase kappa, putative 0.0008 0.0137 0.0917
Loa Loa (eye worm) glutaminase 0.0169 0.4282 0.7891
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Echinococcus multilocularis g protein coupled receptor 0.0141 0.3555 0.3961
Echinococcus multilocularis serotonin receptor 0.0141 0.3555 0.3961
Mycobacterium ulcerans esterase/lipase LipP 0.0061 0.1496 0.3492
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0018 0.0376 0.0694
Trypanosoma brucei unspecified product 0.0008 0.0137 0.0908
Echinococcus multilocularis rhodopsin orphan GPCR 0.0141 0.3555 0.3961
Onchocerca volvulus 0.0061 0.1496 0.4209
Echinococcus granulosus alpha 1A adrenergic receptor 0.0141 0.3555 0.3961
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0141 0.3555 0.3961
Trichomonas vaginalis glutaminase, putative 0.0169 0.4282 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0086 0.0158
Brugia malayi PAN domain containing protein 0.0006 0.0086 0.0158
Onchocerca volvulus 0.0006 0.0086 0.0241
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0141 0.3555 0.6551
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0004 0.0033 0.0037
Echinococcus granulosus tm gpcr rhodopsin 0.0141 0.3555 0.3961
Echinococcus multilocularis neuropeptide Y receptor 0.0141 0.3555 0.3961
Echinococcus multilocularis neuropeptides capa receptor 0.0141 0.3555 0.3961
Trypanosoma brucei unspecified product 0.0006 0.0069 0.0453
Trypanosoma brucei DNA polymerase IV, putative 0.0008 0.0137 0.0908
Brugia malayi Melatonin receptor type 1A 0.0141 0.3555 0.6551
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0029 0.0674 0.0751
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0061 0.1496 0.1495
Loa Loa (eye worm) hypothetical protein 0.0003 0.0001 0.0003
Echinococcus granulosus regulator of G protein signaling 7 0.0004 0.0033 0.0037
Echinococcus granulosus histone acetyltransferase MYST2 0.0033 0.0782 0.0872
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0141 0.3555 0.6551
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0004 0.0033 0.0093
Echinococcus multilocularis geminin 0.035 0.8975 1
Echinococcus multilocularis g-protein coupled receptor 0.0141 0.3555 0.3961
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0061 0.1496 0.3492
Brugia malayi putative neuropeptide receptor 0.0141 0.3555 0.6551
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0008 0.0137 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0004 0.0033 0.0061
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0426 0.0785
Loa Loa (eye worm) hypothetical protein 0.0004 0.0033 0.0061
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0141 0.3555 0.3961
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0004 0.0033 0.0061
Echinococcus granulosus dnaJ subfamily B 0.0179 0.4558 0.5078
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0008 0.013 0.0129
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.1003 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0024 0.0535 0.2122
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0011 0.0202 0.02
Trypanosoma brucei unspecified product 0.0006 0.0069 0.0453
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0322 0.2147
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Onchocerca volvulus 0.0141 0.3555 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0004 0.0033 0.0037
Onchocerca volvulus 0.0004 0.0033 0.0093
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0004 0.0019 0.0021
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0774 0.1426
Echinococcus granulosus segment polarity protein dishevelled 0.0004 0.0033 0.0037
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.4809 0.5358
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0141 0.3555 0.3961
Giardia lamblia DINP protein human, muc B family 0.0008 0.0137 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0202 0.0372
Loa Loa (eye worm) G-protein coupled receptor 0.0141 0.3555 0.6551
Trichomonas vaginalis D-aminoacylase, putative 0.0061 0.1496 0.3494
Trypanosoma cruzi DNA polymerase kappa, putative 0.0008 0.0137 0.0917
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0043 0.1042 0.192
Onchocerca volvulus 0.0006 0.0086 0.0241
Brugia malayi PAN domain containing protein 0.0006 0.0086 0.0158
Schistosoma mansoni lamin 0.0033 0.0774 0.0862
Leishmania major 4-coumarate:coa ligase-like protein 0.0011 0.0202 0.1339
Plasmodium falciparum acyl-CoA synthetase 0.0008 0.013 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0322 0.0594
Onchocerca volvulus 0.0141 0.3555 1
Echinococcus multilocularis lamin dm0 0.0033 0.0774 0.0862
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0141 0.3555 0.3961
Echinococcus multilocularis thyroid hormone receptor alpha 0.0004 0.0033 0.0037
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.1003 0.1118
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0004 0.0033 0.0037
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0322 0.3213
Schistosoma mansoni amine GPCR 0.0141 0.3555 0.3961
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0004 0.0033 0.0037
Brugia malayi AMP-binding enzyme family protein 0.0003 0.0001 0.0003
Loa Loa (eye worm) Smad1 0.0004 0.0011 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0141 0.3555 0.3961
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0003 0.0001 0.0003
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.1003 0.2343
Brugia malayi hypothetical protein 0.0141 0.3555 0.6551
Toxoplasma gondii PAN domain-containing protein 0.0006 0.0086 0.0334
Onchocerca volvulus 0.0043 0.1042 0.2931
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0137 0.0908
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.1003 0.1118
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0061 0.1496 0.1667
Brugia malayi PAN domain containing protein 0.0006 0.0086 0.0158
Schistosoma mansoni histamine h1 receptor 0.0141 0.3555 0.3961
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0141 0.3555 0.3961
Echinococcus granulosus neuropeptide receptor 0.0141 0.3555 0.3961
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0141 0.3555 0.3961
Echinococcus multilocularis beta LACTamase domain containing family member 0.0061 0.1496 0.1667
Echinococcus granulosus neuropeptide receptor A26 0.0141 0.3555 0.3961
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0004 0.0033 0.0037
Onchocerca volvulus 0.0141 0.3555 1
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0426 0.2841
Brugia malayi intermediate filament protein 0.0033 0.0774 0.1426
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0322 0.0753
Schistosoma mansoni neuropeptide F-like receptor 0.0141 0.3555 0.3961
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0003 0.0001 0.001
Schistosoma mansoni acetyl-CoA synthetase 0.0003 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Loa Loa (eye worm) hypothetical protein 0.0006 0.0086 0.0158
Brugia malayi follicle stimulating hormone receptor 0.0141 0.3555 0.6551
Onchocerca volvulus 0.0006 0.0086 0.0241
Trichomonas vaginalis penicillin-binding protein, putative 0.0061 0.1496 0.3494
Brugia malayi hypothetical protein 0.0141 0.3555 0.6551
Onchocerca volvulus 0.0006 0.0086 0.0241
Brugia malayi putative neuropeptide receptor NPR1 0.0141 0.3555 0.6551
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0011 0.0202 0.0468
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0004 0.0033 0.0037
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0331 0.0369
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0061 0.1496 0.1667
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0141 0.3555 0.6551
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0774 0.1426
Echinococcus multilocularis FTZ F1 alpha 0.0004 0.0033 0.0037
Toxoplasma gondii aldehyde dehydrogenase 0.0029 0.0674 0.2674
Schistosoma mansoni neuropeptide F-like receptor 0.0141 0.3555 0.3961
Brugia malayi hypothetical protein 0.0004 0.0033 0.0061
Leishmania major 4-coumarate:coa ligase-like protein 0.0011 0.0202 0.1339
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0004 0.0033 0.0037
Echinococcus granulosus fmrfamide receptor 0.0141 0.3555 0.3961
Schistosoma mansoni dep domain containing protein 0.0004 0.0033 0.0037
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0004 0.0033 0.0037
Brugia malayi PAN domain containing protein 0.0006 0.0086 0.0158
Schistosoma mansoni lamin 0.0033 0.0774 0.0862
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0004 0.0033 0.0061
Loa Loa (eye worm) hypothetical protein 0.0061 0.1496 0.2757
Mycobacterium tuberculosis Probable lipase LipD 0.0061 0.1496 0.1495
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0004 0.0033 0.0037
Schistosoma mansoni alpha-1 adrenergic receptor 0.0141 0.3555 0.3961
Toxoplasma gondii PAN domain-containing protein 0.01 0.2518 1
Mycobacterium tuberculosis Probable hydrolase 0.0061 0.1496 0.1495
Echinococcus granulosus intermediate filament protein 0.0033 0.0774 0.0862
Echinococcus granulosus cpg binding protein 0.0013 0.0263 0.0293
Echinococcus multilocularis orexin receptor type 2 0.0141 0.3555 0.3961
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0141 0.3555 0.3961
Toxoplasma gondii hypothetical protein 0.0006 0.0086 0.0334
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Schistosoma mansoni biogenic amine receptor 0.0141 0.3555 0.3961
Brugia malayi RE15519p 0.0141 0.3555 0.6551
Mycobacterium ulcerans DNA polymerase IV 0.0008 0.0137 0.0317
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Schistosoma mansoni regulator of G protein signaling 0.0004 0.0033 0.0037
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0141 0.3555 0.3961
Echinococcus granulosus Smad4 0.0004 0.0011 0.0012
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0141 0.3555 0.3961
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0141 0.3555 0.3961
Schistosoma mansoni opsin-like receptor 0.0141 0.3555 0.3961
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0141 0.3555 0.3961
Echinococcus multilocularis histone acetyltransferase MYST2 0.0033 0.0782 0.0872
Echinococcus granulosus neuropeptide Y receptor 0.0141 0.3555 0.3961
Brugia malayi glutaminase DH11.1 0.0169 0.4282 0.7891
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0008 0.0137 0.032
Schistosoma mansoni aldehyde dehydrogenase 0.0029 0.0674 0.0751
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0011 0.0202 0.0468
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Brugia malayi MH2 domain containing protein 0.0004 0.0011 0.0019
Echinococcus multilocularis segment polarity protein dishevelled 0.0004 0.0033 0.0037
Onchocerca volvulus 0.0141 0.3555 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.1003 0.2343
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0008 0.013 0.03
Schistosoma mansoni hypothetical protein 0.0178 0.4532 0.5049
Loa Loa (eye worm) oxidoreductase 0.0003 0.0001 0.0003
Echinococcus granulosus orexin receptor type 2 0.0141 0.3555 0.3961
Trypanosoma cruzi DNA polymerase kappa, putative 0.0008 0.0137 0.0917
Loa Loa (eye worm) beta-lactamase 0.0061 0.1496 0.2757
Echinococcus granulosus mothers against decapentaplegic 5 0.0004 0.0011 0.0012
Echinococcus granulosus neuropeptide receptor 0.0141 0.3555 0.3961
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Schistosoma mansoni smad 0.0004 0.0011 0.0012
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0141 0.3555 0.6551
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Schistosoma mansoni biogenic amine (5HT) receptor 0.0141 0.3555 0.3961
Toxoplasma gondii microneme protein, putative 0.0006 0.0086 0.0334
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0137 0.0908
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0008 0.0137 0.0153
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0003 0.0001 0.0003
Brugia malayi G-protein coupled receptor 0.0141 0.3555 0.6551
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Schistosoma mansoni biogenic amine (5HT) receptor 0.0141 0.3555 0.3961
Schistosoma mansoni myelin transcription factor 1 myt1 0.0033 0.0782 0.0872
Schistosoma mansoni adenoreceptor 0.0141 0.3555 0.3961
Loa Loa (eye worm) hypothetical protein 0.0033 0.0782 0.1441
Schistosoma mansoni hypothetical protein 0.0043 0.1042 0.1161
Loa Loa (eye worm) hypothetical protein 0.0015 0.0315 0.0581
Echinococcus granulosus rhodopsin orphan GPCR 0.0141 0.3555 0.3961
Onchocerca volvulus 0.0141 0.3555 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0004 0.0033 0.0037
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0028 0.0639 0.1177
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Loa Loa (eye worm) hypothetical protein 0.0004 0.0033 0.0061
Schistosoma mansoni opsin-like receptor 0.0141 0.3555 0.3961
Schistosoma mansoni hypothetical protein 0.0179 0.4558 0.5078
Onchocerca volvulus 0.0141 0.3555 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0141 0.3555 0.3961
Mycobacterium tuberculosis Probable esterase LipL 0.0061 0.1496 0.1495
Brugia malayi MH2 domain containing protein 0.0052 0.1272 0.2345
Schistosoma mansoni biogenic amine receptor 0.0141 0.3555 0.3961
Loa Loa (eye worm) PAN domain-containing protein 0.0006 0.0086 0.0158
Onchocerca volvulus 0.0033 0.0774 0.2176
Loa Loa (eye worm) hypothetical protein 0.0006 0.0086 0.0158
Schistosoma mansoni hypothetical protein 0.035 0.8975 1
Schistosoma mansoni neuropeptide receptor 0.0141 0.3555 0.3961
Echinococcus granulosus g-protein coupled receptor 0.0141 0.3555 0.3961
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0141 0.3555 0.6551
Brugia malayi N-terminal motif family protein 0.009 0.2248 0.4142
Mycobacterium tuberculosis Probable lipase LipE 0.0061 0.1496 0.1495
Schistosoma mansoni intermediate filament proteins 0.0033 0.0774 0.0862
Echinococcus granulosus tachykinin peptides receptor 99D 0.0141 0.3555 0.3961
Loa Loa (eye worm) hypothetical protein 0.0004 0.0033 0.0061
Echinococcus multilocularis g protein coupled receptor 0.0141 0.3555 0.3961
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Echinococcus multilocularis neuropeptide s receptor 0.0141 0.3555 0.3961
Brugia malayi hypothetical protein 0.0141 0.3555 0.6551
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0141 0.3555 0.6551
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0004 0.0033 0.0061
Loa Loa (eye worm) hypothetical protein 0.0011 0.0202 0.0372
Mycobacterium ulcerans acyl-CoA synthetase 0.0011 0.0202 0.0468
Toxoplasma gondii hypothetical protein 0.0004 0.0033 0.0125
Schistosoma mansoni amine GPCR 0.0141 0.3555 0.3961
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0774 0.1426
Onchocerca volvulus 0.0061 0.1496 0.4209
Entamoeba histolytica deoxycytidyl transferase, putative 0.0008 0.0137 0.1367
Loa Loa (eye worm) hypothetical protein 0.0008 0.013 0.024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0141 0.3555 0.3961
Echinococcus granulosus SAM and MBT domain containing protein 0.0029 0.0677 0.0755
Onchocerca volvulus 0.0141 0.3555 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0011 0.0202 0.1339
Brugia malayi photoreceptor-specific nuclear receptor 0.0004 0.0033 0.0061
Echinococcus multilocularis fmrfamide receptor 0.0141 0.3555 0.3961
Trypanosoma cruzi DNA polymerase kappa, putative 0.0008 0.0137 0.0917
Echinococcus multilocularis serotonin receptor 0.0141 0.3555 0.3961
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.1003 0.2343
Echinococcus multilocularis neuropeptide FF receptor 2 0.0141 0.3555 0.3961
Echinococcus granulosus beta LACTamase domain containing family member 0.0061 0.1496 0.1667
Entamoeba histolytica acyl-CoA synthetase, putative 0.0011 0.0202 0.2009
Brugia malayi mbt repeat family protein 0.0029 0.0677 0.1248
Echinococcus granulosus 7TM GPCR rhodopsin 0.0141 0.3555 0.3961
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0137 0.0908
Loa Loa (eye worm) histone methyltransferase 0.0004 0.0019 0.0035
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0006 0.0086 0.0334
Trichomonas vaginalis esterase, putative 0.0061 0.1496 0.3494
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0004 0.0033 0.0037
Loa Loa (eye worm) hypothetical protein 0.0004 0.0033 0.0061
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0141 0.3555 0.3961
Brugia malayi CXXC zinc finger family protein 0.0013 0.0244 0.045
Echinococcus granulosus smad 0.0004 0.0011 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0028 0.0639 0.0712
Schistosoma mansoni opsin-like receptor 0.0141 0.3555 0.3961
Leishmania major DNA polymerase kappa, putative 0.0008 0.0137 0.0908
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0004 0.0033 0.0061
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Loa Loa (eye worm) hypothetical protein 0.0004 0.0033 0.0061
Onchocerca volvulus 0.0141 0.3555 1
Echinococcus multilocularis G protein coupled receptor 139 0.0141 0.3555 0.3961
Toxoplasma gondii PAN domain-containing protein 0.0006 0.0086 0.0334
Schistosoma mansoni smad1 5 8 and 0.0004 0.0011 0.0012
Schistosoma mansoni alpha glucosidase 0.0042 0.1003 0.1118
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.1003 0.1849
Brugia malayi Tachykinin-like peptides receptor 99D 0.0141 0.3555 0.6551
Echinococcus granulosus lamin dm0 0.0033 0.0774 0.0862
Schistosoma mansoni terminal deoxycytidyl transferase 0.0008 0.0137 0.0153
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0322 0.0753
Toxoplasma gondii ABC1 family protein 0.0061 0.1496 0.5941
Loa Loa (eye worm) hypothetical protein 0.0015 0.0315 0.0581
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0322 0.2155
Brugia malayi Serotonin receptor 0.0141 0.3555 0.6551
Echinococcus multilocularis dna polymerase kappa 0.0008 0.0137 0.0153
Echinococcus granulosus lysosomal alpha glucosidase 0.0189 0.4809 0.5358
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0014 0.0275 0.1088
Onchocerca volvulus 0.0003 0.0001 0.0004
Mycobacterium tuberculosis Conserved protein 0.0061 0.1496 0.1495
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0029 0.0674 0.4501
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0118 0.0117
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0004 0.0033 0.0037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0004 0.0033 0.0037
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0141 0.3555 0.3961
Loa Loa (eye worm) hypothetical protein 0.009 0.2248 0.4142
Loa Loa (eye worm) hypothetical protein 0.0213 0.5427 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0014 0.0275 0.1839
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.1003 0.2343
Leishmania major hypothetical protein, conserved 0.0061 0.1496 1
Onchocerca volvulus 0.0029 0.0677 0.1905
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0137 0.0908
Mycobacterium ulcerans lipase LipD 0.0061 0.1496 0.3492
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0029 0.0677 0.1905
Brugia malayi nuclear hormone receptor 0.0004 0.0033 0.0061
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.1003 0.6703
Brugia malayi ORL1-like opioid receptor 0.0141 0.3555 0.6551
Onchocerca volvulus 0.0141 0.3555 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0004 0.0033 0.0061
Brugia malayi nuclear receptor NHR-88 0.0004 0.0033 0.0061
Brugia malayi AMP-binding enzyme family protein 0.0011 0.0202 0.0372
Mycobacterium leprae conserved hypothetical protein 0.0061 0.1496 1
Echinococcus multilocularis neuropeptides capa receptor 0.0141 0.3555 0.3961
Brugia malayi PAN domain containing protein 0.0006 0.0086 0.0158
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0322 0.0907
Schistosoma mansoni coup transcription factor 0.0004 0.0033 0.0037
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Brugia malayi Glycosyl hydrolases family 31 protein 0.0189 0.4809 0.8861
Loa Loa (eye worm) hypothetical protein 0.0006 0.0086 0.0158
Echinococcus multilocularis allatostatin A receptor 0.0141 0.3555 0.3961
Echinococcus multilocularis lamin 0.0033 0.0774 0.0862
Mycobacterium leprae Probable lipase LipE 0.0061 0.1496 1
Loa Loa (eye worm) steroid hormone receptor 0.0004 0.0033 0.0061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0028 0.0639 0.0712
Brugia malayi AMP-binding enzyme family protein 0.0011 0.0202 0.0372
Brugia malayi steroid hormone receptor 0.0004 0.0033 0.0061
Echinococcus granulosus g protein coupled receptor 0.0141 0.3555 0.3961
Onchocerca volvulus 0.0141 0.3555 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0331 0.061
Schistosoma mansoni nuclear hormone receptor 0.0004 0.0033 0.0037
Loa Loa (eye worm) G-protein coupled receptor 0.0141 0.3555 0.6551
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0004 0.0033 0.0037
Schistosoma mansoni cpg binding protein 0.0013 0.0263 0.0293
Echinococcus multilocularis neuropeptide receptor 0.0141 0.3555 0.3961
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0141 0.3555 0.3961
Mycobacterium ulcerans acyl-CoA synthetase 0.0011 0.0202 0.0468
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0004 0.0019 0.0021
Onchocerca volvulus 0.0006 0.0086 0.0241
Brugia malayi hypothetical protein 0.0141 0.3555 0.6551
Onchocerca volvulus 0.0006 0.0086 0.0241
Trichomonas vaginalis antibiotic synthetase, putative 0.0003 0.0001 0.0003
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.1003 0.1849
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0003 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.035 0.8975 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0033 0.0782 0.1441
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0028 0.0639 0.1177
Loa Loa (eye worm) hypothetical protein 0.0011 0.0202 0.0372
Brugia malayi ImpB/MucB/SamB family protein 0.0008 0.0137 0.0253
Echinococcus multilocularis dro:myosuppressin receptor 0.0141 0.3555 0.3961
Echinococcus granulosus peptide allatostatin:somatostatin 0.0141 0.3555 0.3961
Brugia malayi hypothetical protein 0.0141 0.3555 0.6551
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0118 0.0117
Echinococcus multilocularis fmrfamide receptor 0.0141 0.3555 0.3961
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0141 0.3555 0.3961
Echinococcus granulosus g protein coupled receptor 0.0141 0.3555 0.3961
Toxoplasma gondii hypothetical protein 0.0006 0.0086 0.0334
Echinococcus granulosus serotonin receptor 0.0141 0.3555 0.3961
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.1003 0.2343
Echinococcus multilocularis rhodopsin orphan GPCR 0.0141 0.3555 0.3961
Schistosoma mansoni neuropeptide f receptor 76f 0.0141 0.3555 0.3961
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0141 0.3555 0.3961
Schistosoma mansoni amine GPCR 0.0141 0.3555 0.3961
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0004 0.0033 0.0061
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0426 0.2848
Brugia malayi Serotonin receptor 0.0141 0.3555 0.6551
Echinococcus granulosus neuropeptide s receptor 0.0141 0.3555 0.3961
Echinococcus granulosus regulator of G protein signaling 7 0.0004 0.0033 0.0037
Brugia malayi G protein-coupled receptor F59B2.13 0.0141 0.3555 0.6551
Brugia malayi Dopamine receptor protein 2 0.0141 0.3555 0.6551
Toxoplasma gondii microneme protein MIC17B 0.0006 0.0086 0.0334
Brugia malayi G protein-coupled receptor 0.0141 0.3555 0.6551
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Schistosoma mansoni glutaminase 0.0169 0.4282 0.4771
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0137 0.0908
Brugia malayi F/Y-rich N-terminus family protein 0.0004 0.0018 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.1003 0.6707
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0141 0.3555 0.3961
Schistosoma mansoni hypothetical protein 0.0141 0.3555 0.3961
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0004 0.0033 0.0061
Loa Loa (eye worm) PAN domain-containing protein 0.0006 0.0086 0.0158
Brugia malayi larval opioid receptor 0.0141 0.3555 0.6551
Echinococcus multilocularis rhodopsin orphan GPCR 0.0141 0.3555 0.3961
Loa Loa (eye worm) MH1 domain-containing protein 0.0004 0.0011 0.0019
Brugia malayi hypothetical protein 0.0141 0.3555 0.6551
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Schistosoma mansoni alpha-glucosidase 0.0163 0.4128 0.4599
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0004 0.0011 0.0012
Brugia malayi PAN domain containing protein 0.0006 0.0086 0.0158
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0118 0.0117
Brugia malayi PAN domain containing protein 0.0006 0.0086 0.0158
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0011 0.0202 0.0468
Schistosoma mansoni hypothetical protein 0.0141 0.3555 0.3961
Brugia malayi AMP-binding enzyme family protein 0.0003 0.0001 0.0003
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0141 0.3555 0.3961
Loa Loa (eye worm) TYRA-2 protein 0.0141 0.3555 0.6551
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Trichomonas vaginalis DNA polymerase eta, putative 0.0008 0.0137 0.032
Echinococcus granulosus sex peptide receptor 0.0141 0.3555 0.3961
Brugia malayi Steroid receptor seven-up type 2 0.0004 0.0033 0.0061
Schistosoma mansoni steroid hormone receptor ad4bp 0.0004 0.0033 0.0037
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0004 0.0011 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0028 0.0639 0.0712
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0141 0.3555 0.3961
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0069 0.0453
Echinococcus granulosus neuropeptides capa receptor 0.0141 0.3555 0.3961
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.1003 0.6707
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0137 0.0908
Brugia malayi Dopamine receptor 0.0141 0.3555 0.6551
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0141 0.3555 0.6551
Loa Loa (eye worm) DIX domain-containing protein 0.0004 0.0033 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0004 0.0033 0.0061
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0322 0.0753
Loa Loa (eye worm) mbt repeat family protein 0.0029 0.0677 0.1248
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Echinococcus multilocularis neuropeptide receptor 0.0141 0.3555 0.3961
Onchocerca volvulus Neuropeptide F receptor homolog 0.0141 0.3555 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0011 0.0202 0.0468
Brugia malayi neuropeptide F receptor 0.0141 0.3555 0.6551
Loa Loa (eye worm) hypothetical protein 0.0061 0.1496 0.2757
Brugia malayi Dopamine receptor protein 1 0.0141 0.3555 0.6551
Echinococcus multilocularis mothers against decapentaplegic 5 0.0004 0.0011 0.0012
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0141 0.3555 0.6551
Brugia malayi mbt repeat family protein 0.0029 0.0677 0.1248
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0029 0.0677 0.0755
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0003 0.0001 0.0003
Schistosoma mansoni Smad4 0.0004 0.0011 0.0012
Loa Loa (eye worm) MH2 domain-containing protein 0.0004 0.0011 0.0019
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0141 0.3555 0.3961
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0008 0.013 0.5
Onchocerca volvulus 0.0006 0.0086 0.0241
Schistosoma mansoni retinoic acid receptor RXR 0.0004 0.0033 0.0037
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0141 0.3555 1
Onchocerca volvulus 0.0141 0.3555 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0141 0.3555 0.3961
Brugia malayi AMP-binding enzyme family protein 0.0003 0.0001 0.0003
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0008 0.0137 0.0136
Echinococcus granulosus g protein coupled receptor 0.0141 0.3555 0.3961
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0033 0.0782 0.0872
Entamoeba histolytica acyl-coA synthetase, putative 0.0011 0.0202 0.2009
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Echinococcus granulosus allatostatin A receptor 0.0141 0.3555 0.3961
Mycobacterium tuberculosis Conserved hypothetical protein 0.0008 0.0137 0.0136
Echinococcus granulosus rhodopsin orphan GPCR 0.0141 0.3555 0.3961
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0141 0.3555 0.3961
Onchocerca volvulus 0.0013 0.0244 0.0686
Loa Loa (eye worm) hypothetical protein 0.0004 0.0033 0.0061
Loa Loa (eye worm) hypothetical protein 0.0016 0.0322 0.0594
Echinococcus multilocularis rhodopsin orphan GPCR 0.0141 0.3555 0.3961
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0141 0.3555 0.3961
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0141 0.3555 0.3961
Brugia malayi hypothetical protein 0.0141 0.3555 0.6551
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0141 0.3555 0.3961
Trypanosoma brucei DNA polymerase IV, putative 0.0008 0.0137 0.0908
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0137 0.0908
Brugia malayi beta-lactamase family protein 0.0061 0.1496 0.2757
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0116 0.2909 0.3241
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0141 0.3555 0.3961
Schistosoma mansoni hypothetical protein 0.0141 0.3555 0.3961
Echinococcus granulosus rhodopsin orphan GPCR 0.0141 0.3555 0.3961
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0008 0.0137 0.0908
Schistosoma mansoni smad1 5 8 and 0.0004 0.0011 0.0012
Brugia malayi MH2 domain containing protein 0.0004 0.0011 0.0019
Loa Loa (eye worm) PAN domain-containing protein 0.0006 0.0086 0.0158
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0322 0.0753
Schistosoma mansoni RAR-like nuclear receptor 0.0004 0.0033 0.0037
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.4809 0.5358
Plasmodium vivax hypothetical protein, conserved 0.0061 0.1496 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0011 0.0202 0.1339
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Onchocerca volvulus 0.0061 0.1496 0.4209
Echinococcus multilocularis dna polymerase eta 0.002 0.0426 0.0475
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0003 0.0001 0.0002
Schistosoma mansoni alpha-glucosidase 0.0163 0.4128 0.4599
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0141 0.3555 0.3961
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0069 0.0453
Loa Loa (eye worm) hypothetical protein 0.0004 0.0033 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0141 0.3555 0.3961
Loa Loa (eye worm) PAN domain-containing protein 0.0006 0.0086 0.0158
Echinococcus multilocularis neuropeptide receptor A26 0.0141 0.3555 0.3961
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Brugia malayi hypothetical protein 0.0141 0.3555 0.6551
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Schistosoma mansoni neuropeptide receptor 0.0141 0.3555 0.3961
Schistosoma mansoni smad1 5 8 and 0.0004 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Loa Loa (eye worm) MH2 domain-containing protein 0.0052 0.1272 0.2345
Loa Loa (eye worm) hypothetical protein 0.0061 0.1496 0.2757
Echinococcus multilocularis segment polarity protein dishevelled 0.0004 0.0033 0.0037
Loa Loa (eye worm) hypothetical protein 0.0008 0.013 0.024
Schistosoma mansoni thyroid hormone receptor 0.0004 0.0033 0.0037
Echinococcus granulosus rhodopsin orphan GPCR 0.0141 0.3555 0.3961
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0004 0.0033 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0004 0.0033 0.0061
Entamoeba histolytica acyl-CoA synthetase, putative 0.0011 0.0202 0.2009
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0322 0.2155
Onchocerca volvulus 0.0006 0.0086 0.0241
Loa Loa (eye worm) hypothetical protein 0.0008 0.013 0.024
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0331 0.0369
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Schistosoma mansoni dishevelled 0.0004 0.0033 0.0037
Loa Loa (eye worm) hypothetical protein 0.0033 0.0774 0.1426
Onchocerca volvulus 0.0006 0.0086 0.0241
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0069 0.0453
Brugia malayi beta-lactamase 0.0061 0.1496 0.2757
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0141 0.3555 0.3961
Onchocerca volvulus 0.0033 0.0774 0.2176
Mycobacterium ulcerans aldehyde dehydrogenase 0.0029 0.0674 0.1572
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0008 0.0137 0.0253
Trichomonas vaginalis penicillin-binding protein, putative 0.0061 0.1496 0.3494
Brugia malayi MH1 domain containing protein 0.0004 0.0011 0.0019
Loa Loa (eye worm) hypothetical protein 0.0006 0.0086 0.0158
Brugia malayi hypothetical protein 0.0004 0.0033 0.0061
Schistosoma mansoni biogenic amine receptor 0.0141 0.3555 0.3961
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0028 0.0639 0.0712
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0004 0.0033 0.0061
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0118 0.0117
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0322 0.0753
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Brugia malayi MH1 domain containing protein 0.0004 0.0011 0.0019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0028 0.0639 0.0712
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.1003 0.3982
Onchocerca volvulus 0.0003 0.0001 0.0004
Schistosoma mansoni sex comb on midleg homolog 0.0029 0.0677 0.0755
Loa Loa (eye worm) hypothetical protein 0.0004 0.0033 0.0061
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0029 0.0674 0.0673
Echinococcus multilocularis neuropeptide Y receptor 0.0141 0.3555 0.3961
Loa Loa (eye worm) PAN domain-containing protein 0.0006 0.0086 0.0158
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0137 0.0908
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0061 0.1496 0.2757
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0033 0.0782 0.0872
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0141 0.3555 0.3961
Mycobacterium ulcerans hypothetical protein 0.0061 0.1496 0.3492
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0004 0.0033 0.0061
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0141 0.3555 0.3961
Trichomonas vaginalis D-aminoacylase, putative 0.0061 0.1496 0.3494
Brugia malayi GnHR receptor homolog 0.0141 0.3555 0.6551
Trichomonas vaginalis D-aminoacylase, putative 0.0061 0.1496 0.3494
Schistosoma mansoni sex comb on midleg homolog 0.0029 0.0677 0.0755
Onchocerca volvulus Bile acid receptor homolog 0.0004 0.0033 0.0093
Onchocerca volvulus 0.0003 0.0001 0.0004
Echinococcus granulosus segment polarity protein dishevelled 0.0004 0.0033 0.0037
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0322 0.2147
Brugia malayi Nuclear hormone receptor-like 1 0.0004 0.0033 0.0061
Schistosoma mansoni survival motor neuron protein 0.0043 0.1042 0.1161
Loa Loa (eye worm) hypothetical protein 0.0004 0.0033 0.0061
Loa Loa (eye worm) hypothetical protein 0.0008 0.013 0.024
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0004 0.0033 0.0037
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0141 0.3555 0.3961
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.1003 0.2343
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Schistosoma mansoni hypothetical protein 0.0141 0.3555 0.3961
Loa Loa (eye worm) hypothetical protein 0.0004 0.0033 0.0061
Echinococcus granulosus survival motor neuron protein 1 0.0213 0.5427 0.6047
Loa Loa (eye worm) neuropeptide F receptor 0.0141 0.3555 0.6551
Loa Loa (eye worm) hypothetical protein 0.0003 0.0001 0.0003
Echinococcus granulosus neuropeptide Y receptor 0.0141 0.3555 0.3961
Brugia malayi DIX domain containing protein 0.0004 0.0033 0.0061
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0029 0.0674 0.0751
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0004 0.0033 0.0061
Toxoplasma gondii microneme protein MIC4 0.0006 0.0086 0.0334
Schistosoma mansoni dishevelled 0.0004 0.0033 0.0037
Trichomonas vaginalis antibiotic synthetase, putative 0.0003 0.0001 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0028 0.0639 0.0712
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0137 0.0908
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0141 0.3555 0.3961
Echinococcus multilocularis G-protein coupled receptor, putative 0.0141 0.3555 0.3961
Echinococcus granulosus tm gpcr rhodopsin 0.0141 0.3555 0.3961
Echinococcus multilocularis musashi 0.0033 0.0774 0.0862
Schistosoma mansoni thyroid hormone receptor 0.0004 0.0033 0.0037
Echinococcus granulosus somatostatin receptor 0.0141 0.3555 0.3961
Schistosoma mansoni amine GPCR 0.0141 0.3555 0.3961
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0003 0.0001 0.0003
Echinococcus granulosus Pleckstrin G protein interacting region 0.0004 0.0033 0.0037
Loa Loa (eye worm) melatonin receptor type 1A 0.0141 0.3555 0.6551
Mycobacterium tuberculosis Conserved protein 0.0061 0.1496 0.1495
Echinococcus granulosus FTZ F1 alpha 0.0004 0.0033 0.0037
Onchocerca volvulus 0.0011 0.0202 0.0567
Brugia malayi hypothetical protein 0.0141 0.3555 0.6551
Brugia malayi hypothetical protein 0.0141 0.3555 0.6551
Brugia malayi cytoplasmic intermediate filament protein 0.0018 0.0376 0.0694
Onchocerca volvulus 0.0141 0.3555 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Echinococcus multilocularis regulator of G protein signaling 7 0.0004 0.0033 0.0037
Schistosoma mansoni amine GPCR 0.0141 0.3555 0.3961
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0141 0.3555 0.3961
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0004 0.0033 0.0061
Onchocerca volvulus 0.0141 0.3555 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0011 0.0202 0.1339
Onchocerca volvulus 0.0006 0.0086 0.0241
Echinococcus multilocularis Smad4 0.0004 0.0011 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.1496 1
Echinococcus granulosus ecdysone induced protein 78C 0.0004 0.0033 0.0037
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0008 0.0137 0.0153
Echinococcus granulosus dna polymerase kappa 0.0008 0.0137 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0004 0.0033 0.0061
Loa Loa (eye worm) hypothetical protein 0.0032 0.0758 0.1397
Brugia malayi Smad1 0.0004 0.0011 0.0019
Echinococcus multilocularis somatostatin receptor 0.0141 0.3555 0.3961
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0004 0.0033 0.0061
Onchocerca volvulus 0.0006 0.0086 0.0241
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.1003 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0004 0.0033 0.0061
Echinococcus multilocularis g protein coupled receptor 0.0141 0.3555 0.3961
Onchocerca volvulus 0.0003 0.0001 0.0004
Toxoplasma gondii microneme protein MIC17C 0.0006 0.0086 0.0334
Echinococcus granulosus 7tm_1 domain containing protein 0.0141 0.3555 0.3961
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0004 0.0033 0.0037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0141 0.3555 0.3961
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0141 0.3555 0.3961
Trypanosoma brucei glucosidase, putative 0.0042 0.1003 0.6703
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Schistosoma mansoni cpg binding protein 0.0013 0.0244 0.0272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0004 0.0033 0.0061
Echinococcus granulosus dna polymerase eta 0.002 0.0426 0.0475
Brugia malayi neuropeptide F receptor 0.0141 0.3555 0.6551
Loa Loa (eye worm) hypothetical protein 0.0006 0.0086 0.0158
Brugia malayi PAN domain containing protein 0.0006 0.0086 0.0158
Mycobacterium ulcerans glutaminase 0.0169 0.4282 1
Loa Loa (eye worm) MBCTL1 0.0033 0.0782 0.1441
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0003 0.0001 0.001
Echinococcus granulosus tm gpcr rhodopsin 0.0141 0.3555 0.3961
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0011 0.0202 0.02
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0061 0.1496 0.1495
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0004 0.0033 0.0037
Toxoplasma gondii microneme protein MIC17A 0.0006 0.0086 0.0334
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0141 0.3555 0.3961
Loa Loa (eye worm) hypothetical protein 0.0061 0.1496 0.2757
Echinococcus multilocularis dnaJ subfamily B 0.0179 0.4558 0.5078
Plasmodium vivax acyl-CoA synthetase, putative 0.0008 0.013 0.086
Echinococcus granulosus G protein coupled receptor 139 0.0141 0.3555 0.3961
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Echinococcus granulosus polycomb protein SCMH1 0.0029 0.0677 0.0755
Brugia malayi AMP-binding enzyme family protein 0.0003 0.0001 0.0003
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.1003 0.2343
Onchocerca volvulus 0.0141 0.3555 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0004 0.0033 0.0061
Loa Loa (eye worm) glutaminase 2 0.0169 0.4282 0.7891
Onchocerca volvulus 0.0141 0.3555 1
Schistosoma mansoni neuropeptide receptor 0.0141 0.3555 0.3961
Loa Loa (eye worm) hypothetical protein 0.002 0.0426 0.0785
Toxoplasma gondii PAN domain-containing protein 0.0006 0.0086 0.0334
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0028 0.0639 0.0712
Loa Loa (eye worm) transcription factor SMAD2 0.0052 0.1272 0.2345
Toxoplasma gondii subtilisin SUB12 0.0006 0.0086 0.0334
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0061 0.1496 0.2757
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0189 0.4809 0.8861
Echinococcus multilocularis regulator of G protein signaling 7 0.0004 0.0033 0.0037
Echinococcus multilocularis smad 0.0004 0.0011 0.0012
Mycobacterium ulcerans DNA polymerase IV 0.0008 0.0137 0.0317
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.1003 0.2343
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Echinococcus granulosus neuropeptide FF receptor 2 0.0141 0.3555 0.3961
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0004 0.0033 0.0037
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.009 0.2248 0.6323
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0322 0.0753
Schistosoma mansoni neuropeptide receptor 0.0141 0.3555 0.3961
Echinococcus granulosus hypothetical protein 0.0141 0.3555 0.3961
Loa Loa (eye worm) hypothetical protein 0.0006 0.0086 0.0158
Onchocerca volvulus 0.0141 0.3555 1
Schistosoma mansoni z-protein (S1r protein) 0.0004 0.0033 0.0037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0141 0.3555 0.3961
Schistosoma mansoni myosin xvIII 0.0141 0.3555 0.3961
Brugia malayi PAN domain containing protein 0.0006 0.0086 0.0158
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0003 0.0001 0.0015
Onchocerca volvulus 0.0141 0.3555 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0141 0.3555 0.3961
Echinococcus granulosus lamin 0.0033 0.0774 0.0862
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0003 0.0001 0.001
Echinococcus multilocularis cpg binding protein 0.0013 0.0263 0.0293
Loa Loa (eye worm) hypothetical protein 0.0141 0.3555 0.6551
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0141 0.3555 0.3961
Loa Loa (eye worm) hypothetical protein 0.0004 0.0033 0.0061
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0609 0.0679
Schistosoma mansoni cpg binding protein 0.0013 0.0263 0.0293
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0116 0.2909 0.3241
Echinococcus granulosus dro:myosuppressin receptor 0.0141 0.3555 0.3961
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0004 0.0033 0.0061
Brugia malayi PAN domain containing protein 0.0006 0.0086 0.0158
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0004 0.0033 0.0093
Loa Loa (eye worm) hypothetical protein 0.0061 0.1496 0.2757
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0004 0.0033 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.1496 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0029 0.0677 0.0755
Mycobacterium tuberculosis Conserved protein 0.0061 0.1496 0.1495
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0141 0.3555 0.6551
Loa Loa (eye worm) CXXC zinc finger family protein 0.0013 0.0244 0.045
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0061 0.1496 0.1495
Mycobacterium ulcerans beta-lactamase 0.0061 0.1496 0.3492
Schistosoma mansoni DNA polymerase eta 0.002 0.0426 0.0475
Trypanosoma brucei hypothetical protein, conserved 0.0061 0.1496 1
Echinococcus granulosus neuropeptides capa receptor 0.0141 0.3555 0.3961
Brugia malayi G-protein coupled receptor 0.0141 0.3555 0.6551
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0141 0.3555 0.6551
Onchocerca volvulus 0.0004 0.0033 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0141 0.3555 0.3961
Loa Loa (eye worm) hypothetical protein 0.0008 0.013 0.024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0141 0.3555 0.3961
Mycobacterium ulcerans aldehyde dehydrogenase 0.0029 0.0674 0.1572
Toxoplasma gondii PAN domain-containing protein 0.0006 0.0086 0.0334
Brugia malayi AKH receptor 0.0141 0.3555 0.6551
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0004 0.0033 0.0061
Echinococcus granulosus biogenic amine 5HT receptor 0.0141 0.3555 0.3961
Echinococcus granulosus geminin 0.035 0.8975 1
Onchocerca volvulus 0.0109 0.2747 0.7727

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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