Detailed information for compound 848687

Basic information

Technical information
  • TDR Targets ID: 848687
  • Name: 2-[(4-fluorophenyl)methyl]-4-[4-(2-fluorophen yl)piperazine-1-carbonyl]-3-(4-methoxyphenyl) -3,4-dihydroisoquinolin-1-one
  • MW: 567.625 | Formula: C34H31F2N3O3
  • H donors: 0 H acceptors: 2 LogP: 5.37 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)C1N(Cc2ccc(cc2)F)C(=O)c2c(C1C(=O)N1CCN(CC1)c1ccccc1F)cccc2
  • InChi: 1S/C34H31F2N3O3/c1-42-26-16-12-24(13-17-26)32-31(34(41)38-20-18-37(19-21-38)30-9-5-4-8-29(30)36)27-6-2-3-7-28(27)33(40)39(32)22-23-10-14-25(35)15-11-23/h2-17,31-32H,18-22H2,1H3
  • InChiKey: VOVKGZISBKLVED-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-fluorophenyl)methyl]-4-[[4-(2-fluorophenyl)-1-piperazinyl]-oxomethyl]-3-(4-methoxyphenyl)-3,4-dihydroisoquinolin-1-one
  • 2-(4-fluorobenzyl)-4-[4-(2-fluorophenyl)piperazine-1-carbonyl]-3-(4-methoxyphenyl)-3,4-dihydroisocarbostyril
  • 2-[(4-fluorophenyl)methyl]-4-[4-(2-fluorophenyl)piperazin-1-yl]carbonyl-3-(4-methoxyphenyl)-3,4-dihydroisoquinolin-1-one
  • EU-0088155

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.1593 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.0247 0.0684
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0072 0.14
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.1139 0.3344
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0552 0.3158 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.011 0.0284
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0055 0.0247 0.0684
Echinococcus granulosus mannose 6 phosphate isomerase 0.0095 0.048 0.1243
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.003 0.0102 0.0289
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0355 0.0977
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0033 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0192 0.0623
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0198 0.0802
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0253 0.0653
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0348 0.1965 0.6402
Schistosoma mansoni lozenge 0.0054 0.0242 0.0625
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0078 0.0382 0.6271
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0046 0.0198 0.0641
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0117 0.0333
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0552 0.3158 1
Giardia lamblia DNA damage repair protein 0.0028 0.0089 0.0365
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0593 0.3399 1
Loa Loa (eye worm) runx1 0.0054 0.0242 0.0787
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0464 0.151
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0355 0.2225
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0081 0.0262
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0108 0.035
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0.0001 0.00000000087403
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0032 0.062
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0081 0.0398 0.103
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0204 0.0661
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.011 0.0282
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0003 0.0008
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0052 0.006
Loa Loa (eye worm) hypothetical protein 0.0432 0.2452 0.7989
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0135 0.0437
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0033 0.0003
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0066 0.1292
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0035 0.0128 0.2081
Trypanosoma brucei DNA polymerase kappa, putative 0.0116 0.0607 0.1779
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0072 0.116
Trypanosoma brucei polo-like protein kinase 0.0092 0.0464 0.1357
Loa Loa (eye worm) hypothetical protein 0.0094 0.0474 0.154
Trypanosoma cruzi DNA polymerase eta, putative 0.0078 0.0382 0.1115
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0464 0.12
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0003 0.0008
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0072 0.02
Trypanosoma cruzi DNA polymerase eta, putative 0.014 0.0746 0.2187
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0355 0.1036
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0094 0.0474 0.0474
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0099 0.0505 1
Toxoplasma gondii transporter, cation channel family protein 0.002 0.004 0.0645
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0064 0.0204
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0001 0.0003
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.04 0.1033
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0015 0.0034
Echinococcus granulosus Chromo domain 0.0013 0.0001 0.0003
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0464 0.189
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0135 0.0437
Loa Loa (eye worm) hypothetical protein 0.0055 0.0247 0.08
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0051 0.0226 0.0562
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0235 0.0763
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0066 0.0184
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0052 0.006
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0046 0.0147
Loa Loa (eye worm) calcium channel 0.0094 0.0474 0.154
Mycobacterium tuberculosis Conserved hypothetical protein 0.0101 0.0518 0.1553
Schistosoma mansoni terminal deoxycytidyl transferase 0.009 0.0453 0.1171
Schistosoma mansoni patched 1 0.0048 0.0205 0.0529
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0355 0.1032
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0355 0.1032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0081 0.0262
Echinococcus granulosus phd:f box containing protein 0.0015 0.0015 0.0039
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0052 0.006
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0091 0.0457 0.1337
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0135 0.2204
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0355 0.0977
Loa Loa (eye worm) apoptosis regulator protein 0.0081 0.0398 0.1293
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0052 0.0318
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.074 0.2263
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0089 0.0253
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0015 0.0034
Schistosoma mansoni microtubule-associated protein tau 0.0673 0.3862 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0052 0.006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0044 0.014
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0198 0.0198
Brugia malayi jmjC domain containing protein 0.0061 0.0281 0.0913
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0057 0.0259 0.0752
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0052 0.006
Schistosoma mansoni DNA polymerase IV / kappa 0.0028 0.0089 0.0229
Onchocerca volvulus 0.0035 0.0128 0.0519
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0033 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0052 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0184 0.0597
Mycobacterium ulcerans hypothetical protein 0.0024 0.0065 0.0104
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.0717 0.2332
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.011 0.011
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0015 0.0015
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0135 0.0437
Loa Loa (eye worm) hypothetical protein 0.0055 0.0247 0.08
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1593 0.5188
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0003 0.0008
Brugia malayi hypothetical protein 0.0025 0.0072 0.023
Brugia malayi CHE-14 protein 0.0048 0.0205 0.0666
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0552 0.3158 1
Schistosoma mansoni hypothetical protein 0.0031 0.0108 0.0278
Treponema pallidum licC protein (licC) 0.0101 0.0518 0.3112
Toxoplasma gondii phosphomannose isomerase type I protein 0.0095 0.048 0.7882
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.011 0.1789
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0032 0.0513
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0091 0.0457 0.0457
Schistosoma mansoni hypothetical protein 0.0348 0.1965 0.5088
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0065 0.0209
Trichomonas vaginalis rotamase, putative 0.0033 0.0116 0.0375
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0109 0.0351
Leishmania major hypothetical protein, conserved 0.0207 0.1139 0.3344
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0153 0.3011
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0091 0.0457 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0008
Loa Loa (eye worm) RecQ helicase 0.0044 0.0184 0.0597
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0204 0.0661
Trypanosoma brucei glucosidase, putative 0.0036 0.0135 0.0387
Trypanosoma brucei DNA polymerase kappa, putative 0.0116 0.0607 0.1779
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0033 0.0086
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0097 0.0492 0.1468
Echinococcus granulosus voltage dependent calcium channel 0.0094 0.0474 0.1226
Brugia malayi mbt repeat family protein 0.0046 0.0198 0.0641
Loa Loa (eye worm) hypothetical protein 0.0018 0.0032 0.0102
Entamoeba histolytica acyl-coA synthetase, putative 0.0073 0.0355 0.2225
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.004 0.0158 0.0409
Mycobacterium tuberculosis Conserved hypothetical protein 0.0101 0.0518 0.1553
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0015 0.0036
Schistosoma mansoni cpg binding protein 0.0064 0.03 0.0774
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0112 0.0694
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0116 0.0607 0.1976
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0355 0.1032
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0045
Trypanosoma brucei DNA polymerase IV, putative 0.0116 0.0607 0.1779
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0033 0.0103
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0081 0.0262
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0035 0.0035
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0281 0.0726
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0052 0.006
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0095 0.048 0.048
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0065 0.0182
Onchocerca volvulus 0.0044 0.0185 0.0752
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.087 0.2252
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0052 0.006
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0052 0.006
Loa Loa (eye worm) hypothetical protein 0.0099 0.0503 0.1637
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0059 0.0084
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0198 0.0509
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1593 0.5188
Brugia malayi Pre-SET motif family protein 0.0205 0.1127 0.3669
Trypanosoma cruzi phosphomannose isomerase, putative 0.0095 0.048 0.1404
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0048 0.0048
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0032 0.0102
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0052 0.006
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0052 0.006
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0091 0.0457 0.1337
Loa Loa (eye worm) glutaminase 2 0.0537 0.307 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0116 0.0607 0.1976
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0108 0.0108
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0052 0.0165
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0021 0.0055
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0135 0.0437
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0052 0.006
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0089 0.0253
Echinococcus multilocularis expressed protein 0.0033 0.0116 0.0116
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0552 0.3158 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0492 0.1437
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0052 0.006
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0032 0.0102
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0355 0.2225
Brugia malayi ImpB/MucB/SamB family protein 0.014 0.0746 0.2429
Brugia malayi ImpB/MucB/SamB family protein 0.009 0.0453 0.1474
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0464 0.2911
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0048 0.0123
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0052 0.006
Loa Loa (eye worm) hypothetical protein 0.0031 0.011 0.0354
Schistosoma mansoni chromobox protein 0.0079 0.0387 0.1
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0081 0.0398 0.0398
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0015 0.0045
Entamoeba histolytica hypothetical protein 0.0041 0.0164 0.1023
Giardia lamblia DINP protein human, muc B family 0.0097 0.0492 0.2943
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0052 0.0142
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0033 0.0086
Mycobacterium tuberculosis Conserved hypothetical protein 0.009 0.0453 0.1346
Schistosoma mansoni hypothetical protein 0.0286 0.1601 0.4145
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0038 0.0121
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0059 0.0084
Loa Loa (eye worm) hypothetical protein 0.0134 0.0712 0.2317
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0116 0.0375
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0135 0.0387
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0094 0.0474 0.1226
Loa Loa (eye worm) hypothetical protein 0.0171 0.0927 0.3017
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0355 0.1154
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0081 0.0262
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0059 0.0273 0.4472
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0198 0.0512
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0328 0.0955
Loa Loa (eye worm) hypothetical protein 0.0073 0.0355 0.1154
Trypanosoma brucei DNA polymerase kappa, putative 0.0116 0.0607 0.1779
Trichomonas vaginalis set domain proteins, putative 0.0233 0.1291 0.4203
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0272 0.0765
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0503 0.1637
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0117 0.19
Mycobacterium ulcerans glutaminase 0.0537 0.307 0.9717
Loa Loa (eye worm) hypothetical protein 0.0432 0.2452 0.7989
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0033 0.0085
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0464 0.151
Mycobacterium ulcerans DNA polymerase IV 0.0116 0.0607 0.1839
Toxoplasma gondii hypothetical protein 0.0017 0.0026 0.0417
Echinococcus granulosus voltage dependent calcium channel 0.002 0.004 0.0104
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0059 0.0167
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0235 0.0609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0229 0.0628
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0108 0.028
Echinococcus multilocularis protein dispatched 1 0.0055 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0165
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0095 0.048 0.1562
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.1019 0.1019
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.0355 0.1032
Echinococcus granulosus chromobox protein 1 0.0079 0.0387 0.1002
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0094 0.0474 0.1226
Echinococcus multilocularis Protein lozenge 0.0054 0.0242 0.0242
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.049 0.1265
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0116 0.0375
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0108 0.035
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0116 0.0375
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0052 0.0142
Trypanosoma cruzi DNA polymerase kappa, putative 0.0116 0.0607 0.1779
Schistosoma mansoni hypothetical protein 0.0031 0.0108 0.0278
Trypanosoma brucei phosphomannose isomerase 0.0095 0.048 0.1404
Echinococcus granulosus Chromobox protein 3 0.0013 0.0001 0.0003
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0101 0.0518 0.1553
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1593 0.5188
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0198 0.0509
Schistosoma mansoni glutaminase 0.0537 0.307 0.7947
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0064 0.0177
Schistosoma mansoni SET domain protein 0.0016 0.002 0.005
Trypanosoma brucei DNA polymerase eta, putative 0.014 0.0746 0.2187
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0117 0.0333
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0464 0.151
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0034 0.0126 0.0327
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0205 0.0666
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0464 0.1202
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0015 0.0039
Echinococcus multilocularis voltage dependent calcium channel 0.0094 0.0474 0.0474
Brugia malayi mbt repeat family protein 0.0046 0.0198 0.0641
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0081 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0015
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0281 0.1569 0.4612
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0099 0.0505 1
Mycobacterium ulcerans hypothetical protein 0.0313 0.1755 0.5511
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0015 0.0036
Schistosoma mansoni hypothetical protein 0.0046 0.0195 0.0503
Loa Loa (eye worm) hypothetical protein 0.0031 0.0108 0.035
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0272 0.0765
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0328 0.0955
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.049 0.1592
Echinococcus granulosus snurportin 1 0.0348 0.1965 0.5089
Plasmodium falciparum DNA repair protein REV1, putative 0.0028 0.0089 0.1752
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0032 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0015
Brugia malayi Heterochromatin protein 1 0.0079 0.0387 0.1258
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0165
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0033 0.0086
Schistosoma mansoni rotamase 0.0033 0.0116 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0015
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0066 0.0212
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0026 0.0065
Schistosoma mansoni DNA helicase recq5 0.0018 0.0032 0.0081
Entamoeba histolytica hypothetical protein 0.0023 0.0059 0.0363
Loa Loa (eye worm) MBCTL1 0.0053 0.0235 0.0763
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0052 0.0833
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0052 0.0142
Brugia malayi hypothetical protein 0.0016 0.002 0.0061
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0045
Brugia malayi MH2 domain containing protein 0.0135 0.0717 0.2332
Trypanosoma brucei DNA polymerase kappa, putative 0.0116 0.0607 0.1779
Echinococcus multilocularis chromobox protein 2 0.0013 0.0001 0.0001
Brugia malayi CXXC zinc finger family protein 0.0061 0.028 0.0908
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1593 0.5188
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.011 0.0282
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0066 0.0184
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0081 0.0398 0.1293
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0013 0.0001 0.00000000072426
Echinococcus granulosus Niemann Pick C1 protein 0.0111 0.0578 0.1496
Mycobacterium ulcerans DNA polymerase IV 0.0116 0.0607 0.1839
Echinococcus multilocularis snurportin 1 0.0348 0.1965 0.1965
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.049 0.1267
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0198 0.0641
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.087 0.2831
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0135 0.0437
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0033 0.063
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0113 0.0588 0.152
Loa Loa (eye worm) hypothetical protein 0.0073 0.0355 0.1154
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0052 0.006
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.0015 0.0276
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0111 0.0578 0.188
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0135 0.0437
Loa Loa (eye worm) heterochromatin protein 1 0.0079 0.0387 0.1258
Onchocerca volvulus 0.0171 0.0927 0.3777
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0261 0.0676
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0081 0.0398 0.1028
Schistosoma mansoni ran 0.0024 0.0066 0.0169
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0032 0.0032
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0065 0.0169
Schistosoma mansoni voltage-gated cation channel 0.0094 0.0474 0.1224
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0102 0.0521 0.1523
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0052 0.006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0116 0.0607 0.1779
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0091 0.0457 0.1182
Loa Loa (eye worm) hypothetical protein 0.0048 0.0205 0.0666
Loa Loa (eye worm) hypothetical protein 0.0055 0.0247 0.08
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0099 0.0505 0.1642
Echinococcus multilocularis Niemann Pick C1 protein 0.0111 0.0578 0.0578
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0059 0.0084
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0095 0.048 0.1562
Loa Loa (eye worm) hypothetical protein 0.014 0.0746 0.2429
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0065 0.0104
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0272 0.0704
Echinococcus granulosus dna polymerase eta 0.014 0.0746 0.1932
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0083
Trypanosoma cruzi DNA damage repair protein, putative 0.0028 0.0089 0.0253
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.008 0.0259
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0028 0.0089 0.1452
Brugia malayi hypothetical protein 0.0041 0.0164 0.0531
Schistosoma mansoni hypothetical protein 0.0046 0.0195 0.0503
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0072 0.14
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0164 0.0422
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0001 0.00000000087403
Trypanosoma brucei DNA polymerase IV, putative 0.0116 0.0607 0.1779
Echinococcus multilocularis sodium channel protein 0.004 0.0158 0.0158
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0464 0.151
Loa Loa (eye worm) hypothetical protein 0.0064 0.0302 0.0981
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0095 0.048 0.1562
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0052 0.0833
Echinococcus multilocularis bloom syndrome protein 0.0044 0.0184 0.0184
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0052 0.006
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0032 0.0102
Trichomonas vaginalis rotamase, putative 0.0032 0.0112 0.036
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0059 0.0084
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0003 0.0008
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0083 0.0414 0.1209
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0094 0.0474 0.1224
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0052 0.0165
Loa Loa (eye worm) hypothetical protein 0.0033 0.0117 0.0376
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0032 0.011 0.0247
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0205 0.0532
Loa Loa (eye worm) hypothetical protein 0.0054 0.0243 0.079
Leishmania major importin beta-1 subunit, putative 0.0026 0.008 0.0226
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0015 0.0034
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.009 0.0453 0.1174
Loa Loa (eye worm) hypothetical protein 0.0055 0.0247 0.08
Mycobacterium ulcerans hypothetical protein 0.0101 0.0518 0.1553
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0503 0.1637
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0235 0.0235
Schistosoma mansoni hypothetical protein 0.0081 0.0398 0.1028
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0015
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.04 0.1035
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0052 0.0165
Schistosoma mansoni kinase 0.0047 0.0199 0.0514
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.013 0.0333
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0034 0.0126 0.0126
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0593 0.3399 1
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0095 0.048 0.9511
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.011 0.0282
Entamoeba histolytica hypothetical protein 0.0041 0.0164 0.1023
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0052 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0116 0.0607 0.1779
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.04 0.04
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0066 0.107
Schistosoma mansoni hypothetical protein 0.0067 0.0321 0.0827
Leishmania major DNA polymerase eta, putative 0.014 0.0746 0.2187
Echinococcus multilocularis GPCR, family 2 0.0031 0.0108 0.0108
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0355 0.1154
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0052 0.0165
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.1019 0.2639
Schistosoma mansoni hypothetical protein 0.0013 0.0001 0.00000000011403
Loa Loa (eye worm) oxidoreductase 0.0022 0.0052 0.0165
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0001 0.00000000014349
Loa Loa (eye worm) hypothetical protein 0.0081 0.04 0.1299
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1127 0.3669
Loa Loa (eye worm) hypothetical protein 0.0067 0.0321 0.1041
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0073 0.0355 0.1032
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0328 0.0955
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0052 0.0142
Echinococcus multilocularis chromobox protein 1 0.0079 0.0387 0.0387
Schistosoma mansoni ran 0.0024 0.0066 0.0169
Trypanosoma brucei unspecified product 0.0062 0.0289 0.0842
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0032 0.0513
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.008 0.0226
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0052 0.1005
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0091 0.0457 0.1184
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0066 0.0066
Mycobacterium ulcerans hypothetical protein 0.0024 0.0065 0.0104
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0052 0.0134
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0021 0.0066
Echinococcus multilocularis tumor protein p63 0.0383 0.2165 0.2165
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0015 0.0045
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.087 0.087
Leishmania major DNA polymerase kappa, putative 0.0097 0.0492 0.1437
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0321 0.1041
Echinococcus granulosus cpg binding protein 0.0064 0.03 0.0776
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0059 0.0951
Echinococcus granulosus dnaJ subfamily B 0.0399 0.2259 0.5849
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0072 0.14
Echinococcus granulosus GPCR family 2 0.0031 0.0108 0.028
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.04 0.1299
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.1593 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0229 0.0628
Echinococcus granulosus dna polymerase kappa 0.0116 0.0607 0.1573
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0003 0.0016
Onchocerca volvulus 0.0073 0.0355 0.1445
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0112 0.0318
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0065 0.0104
Loa Loa (eye worm) X11 protein 0.0067 0.0317 0.1031
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.0184 0.0597
Schistosoma mansoni amyloid beta A4 protein related 0.0067 0.0317 0.0819
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0059 0.0951
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1593 0.5188
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0055 0.0247 0.08
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0066 0.0212
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.006 0.0276 0.0896
Leishmania major mitochondrial DNA polymerase beta 0.0593 0.3399 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0116 0.0607 0.1779
Plasmodium falciparum importin beta, putative 0.0033 0.0117 0.2293
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0033 0.063
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0128
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0272 0.0701
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0052 0.006
Schistosoma mansoni alpha-glucosidase 0.0139 0.0738 0.191
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0033 0.0103
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0081 0.0262
Toxoplasma gondii hypothetical protein 0.0096 0.0486 0.7972
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0272 0.0765
Echinococcus multilocularis expressed conserved protein 0.0105 0.0538 0.0538
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0243 0.0707
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0089 0.0253
Entamoeba histolytica hypothetical protein 0.0041 0.0164 0.1023
Trichomonas vaginalis glutaminase, putative 0.0537 0.307 1
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0059 0.0163
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0272 0.0272
Mycobacterium tuberculosis Conserved hypothetical protein 0.0313 0.1755 0.5511
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0052 0.006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0081 0.0262
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0091 0.0457 0.1337
Echinococcus granulosus expressed protein 0.0033 0.0116 0.03
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0091 0.0457 0.2722
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0001 0.00000000027661
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0033 0.0086
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0065 0.0104
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.00000000014349
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0015 0.0015
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0015 0.0039
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0064 0.0393
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0083 0.0414 0.1209
Trypanosoma cruzi DNA damage repair protein, putative 0.0028 0.0089 0.0253
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0001 0.00000000014349
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0015 0.0039
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0052 0.006
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0052 0.006
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0387 0.1258
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0229 0.0628
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0052 0.0833
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0001 0.00000000014349
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.01 0.1972
Schistosoma mansoni SET domain protein 0.0034 0.0126 0.0325
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0135 0.0437
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0052 0.0165
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0184 0.0597
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0015 0.0036
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0094 0.0474 0.1224
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0066 0.0171
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0059 0.0023
Schistosoma mansoni chromobox protein 0.0079 0.0387 0.1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.0689 0.1782
Echinococcus multilocularis voltage dependent calcium channel 0.0094 0.0474 0.0474
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0035 0.0091
Leishmania major DNA polymerase eta, putative 0.0078 0.0382 0.1115
Trichomonas vaginalis importin beta-1, putative 0.0026 0.008 0.0259
Trypanosoma brucei RNA helicase, putative 0.0102 0.0525 0.1537
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0091 0.0457 0.1359
Mycobacterium ulcerans hypothetical protein 0.0028 0.0089 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0015
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0026 0.0026
Trichomonas vaginalis ran, putative 0.0024 0.0066 0.0212
Plasmodium vivax acyl-CoA synthetase, putative 0.0055 0.0247 0.4875
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0015 0.0036
Entamoeba histolytica hypothetical protein 0.0041 0.0164 0.1023
Loa Loa (eye worm) hypothetical protein 0.0035 0.0128 0.0415
Onchocerca volvulus 0.0081 0.04 0.1627
Echinococcus multilocularis dna polymerase eta 0.014 0.0746 0.0746
Schistosoma mansoni hypothetical protein 0.0081 0.0398 0.1028
Schistosoma mansoni hypothetical protein 0.0046 0.0195 0.0503
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0094 0.0474 0.0474
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.049 0.1265
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0192 0.0623
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0015
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0052 0.006
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0112 0.0318
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0281 0.0913
Leishmania major DNA damage repair protein, putative 0.0028 0.0089 0.0253
Echinococcus granulosus bloom syndrome protein 0.0044 0.0184 0.0477
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0185 0.0477
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0044 0.014
Echinococcus multilocularis protein patched 0.0048 0.0205 0.0205
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0066 0.0217
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0073 0.0355 0.1032
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0021 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0243 0.0707
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0464 0.151
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0261 0.0261
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0272 0.4455
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0235 0.0609
Entamoeba histolytica Ran family GTPase 0.0024 0.0066 0.0409
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0015 0.0229
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.049 0.1267
Trypanosoma brucei hypothetical protein, conserved 0.0207 0.1139 0.3344
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0032 0.0083
Echinococcus granulosus chromobox protein 1 0.0079 0.0387 0.1002
Echinococcus granulosus expressed conserved protein 0.0105 0.0538 0.1394
Echinococcus granulosus amyloid beta A4 protein 0.0067 0.0317 0.0822
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0205 0.0666
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0015
Trypanosoma brucei DNA damage repair protein, putative 0.0028 0.0089 0.0253
Plasmodium vivax importin-beta 2, putative 0.0033 0.0117 0.2293
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0111 0.0578 0.3624
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0094 0.0474 0.154
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0052 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0015
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0083 0.0414 0.1209
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0065 0.0182
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0198 0.0198
Trypanosoma brucei unspecified product 0.011 0.0569 0.1666
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0059 0.0273 0.0768
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0089 0.0232
Schistosoma mansoni hypothetical protein 0.0041 0.0164 0.0422
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0117 0.0117
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0198 0.0509
Leishmania major DNA polymerase kappa, putative 0.0028 0.0089 0.0253
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0503 0.1637
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0066 0.1292
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0095 0.048 0.1432
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0003 0.0008
Schistosoma mansoni apoptosis regulator bax 0.0081 0.0398 0.1028
Brugia malayi Importin beta-1 subunit 0.0033 0.0117 0.0376
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.011 0.011
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0387 0.1258
Loa Loa (eye worm) hypothetical protein 0.0044 0.0184 0.0597
Onchocerca volvulus 0.0022 0.0052 0.0207
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0052 0.0142
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0073 0.0355 0.1032
Loa Loa (eye worm) hypothetical protein 0.0081 0.0398 0.1293
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0281 0.1569 0.4612
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0032 0.0032
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0135 0.0842
Mycobacterium ulcerans hypothetical protein 0.0101 0.0518 0.1553
Plasmodium vivax DNA repair protein REV1, putative 0.0028 0.0089 0.1752
Schistosoma mansoni ap endonuclease 0.0018 0.0033 0.0082
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0033 0.0103
Mycobacterium tuberculosis Conserved protein 0.0024 0.0065 0.0104
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0065 0.0065
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0355 0.1036
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0135 0.0387
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0355 0.1154
Echinococcus granulosus chromobox protein 2 0.0013 0.0001 0.0003
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0029 0.0097 0.0274
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1593 0.5188
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0033 0.0199
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0281 0.0726
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0034 0.0004
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0609 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0135 0.0437
Brugia malayi jmjC domain containing protein 0.0015 0.0015 0.0045
Echinococcus multilocularis microtubule associated protein 2 0.0673 0.3862 0.3862
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0052 0.0165
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0003 0.0008
Brugia malayi glucose-6-phosphate dehydrogenase 0.0091 0.0457 0.1487
Loa Loa (eye worm) glutaminase 0.0537 0.307 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0052 0.0142
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0464 0.1357
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0083
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0003 0.0008
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0052 0.0165
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.049 0.049
Leishmania major hypothetical protein, conserved 0.0025 0.0072 0.02
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.049 0.1265
Trypanosoma brucei DNA polymerase kappa, putative 0.0116 0.0607 0.1779
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.087 0.087
Plasmodium vivax SET domain protein, putative 0.0031 0.011 0.2158
Onchocerca volvulus 0.0093 0.0472 0.192
Schistosoma mansoni alpha-glucosidase 0.0139 0.0738 0.191
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0045
Brugia malayi hypothetical protein 0.0432 0.2452 0.7989
Trypanosoma brucei DNA polymerase kappa, putative 0.0116 0.0607 0.1779
Trypanosoma brucei DNA damage repair protein, putative 0.0028 0.0089 0.0253
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0095 0.048 0.1562
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0001 0.00000000014349
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0112 0.0318
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0015 0.0015
Schistosoma mansoni importin beta-1 0.0033 0.0117 0.0299
Schistosoma mansoni ap endonuclease 0.0018 0.0033 0.0082
Leishmania major GTP-binding protein, putative 0.0024 0.0066 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0109 0.0351
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.008 0.0259
Loa Loa (eye worm) hypothetical protein 0.0053 0.0235 0.0763
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0052 0.006
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0235 0.0607
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0015 0.0045
Schistosoma mansoni hypothetical protein 0.0102 0.0525 0.1358
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0272 0.0765
Trypanosoma cruzi DNA polymerase kappa, putative 0.0116 0.0607 0.1779
Entamoeba histolytica hypothetical protein 0.0026 0.008 0.0499
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0052 0.1005
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0101 0.0518 0.8507
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.1139 0.3344
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0464 0.151
Brugia malayi jmjC domain containing protein 0.0057 0.0261 0.0847
Schistosoma mansoni mannose-6-phosphate isomerase 0.0095 0.048 0.1241
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0464 0.151
Plasmodium vivax JmjC domain containing protein 0.0015 0.0015 0.0276
Echinococcus granulosus importin subunit beta 1 0.0033 0.0117 0.0302
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0065 0.0104
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0099 0.0505 0.1642
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0184 0.0597
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0099 0.0505 0.8286
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0095 0.048 0.9511
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0164 0.0424
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0072 0.02
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0026 0.0067
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.074 0.2216
Mycobacterium ulcerans hypothetical protein 0.0073 0.0355 0.1032
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0072 0.02
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0095 0.048 0.1562
Loa Loa (eye worm) hypothetical protein 0.0059 0.0268 0.0872
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0135 0.035
Brugia malayi SET domain containing protein 0.0016 0.0021 0.0066
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0135 0.0437
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0112 0.0318
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0261 0.0261
Leishmania major hypothetical protein, conserved 0.0015 0.0015 0.0034
Echinococcus multilocularis amyloid beta A4 protein 0.0067 0.0317 0.0317
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.009 0.0453 0.1474
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0094 0.0474 0.1226
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0198 0.0512
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0043 0.0179 0.1121
Brugia malayi jmjC domain containing protein 0.0015 0.0015 0.0045
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0205 0.0532
Schistosoma mansoni alpha glucosidase 0.0036 0.0135 0.0347
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0081 0.0262
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0097 0.0492 0.1437
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.1593 1
Onchocerca volvulus 0.0046 0.0198 0.0802
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0021 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1593 0.5188
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0052 0.0131
Brugia malayi jmjC domain containing protein 0.0015 0.0015 0.0045
Onchocerca volvulus 0.0056 0.0253 0.1029
Brugia malayi hypothetical protein 0.0171 0.0927 0.3017
Toxoplasma gondii exonuclease III APE 0.0018 0.0033 0.0522
Loa Loa (eye worm) voltage-dependent calcium channel 0.002 0.004 0.0128
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0464 0.1357
Onchocerca volvulus 0.0022 0.0052 0.0207
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.2259 0.2259
Onchocerca volvulus 0.0061 0.028 0.1137
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0204 0.0828
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0464 0.1357
Trypanosoma brucei DNA polymerase kappa, putative 0.0116 0.0607 0.1779
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0003 0.0008
Brugia malayi RNA, U transporter 1 0.0093 0.0469 0.1525
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0108 0.028
Giardia lamblia Kinase, PLK 0.0092 0.0464 0.2769
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0099 0.0505 0.3028
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0091 0.0457 0.1487
Brugia malayi glutaminase DH11.1 0.0537 0.307 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0052 0.0142
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0272 0.079
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0001 0.00000000014349
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0052 0.006
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0052 0.0165
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.009 0.0453 0.0453
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0026 0.0026
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0108 0.035
Schistosoma mansoni hypothetical protein 0.0046 0.0195 0.0503
Echinococcus multilocularis dna polymerase kappa 0.0116 0.0607 0.0607
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0059 0.1148
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0048 0.0152
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0261 0.0673
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.0184 0.0597
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0184 0.0748
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.028 0.0908
Trypanosoma brucei DNA polymerase IV, putative 0.011 0.0569 0.1666
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0057 0.0259 0.0752
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0229 0.0628
Brugia malayi Pre-SET motif family protein 0.0031 0.011 0.0354
Echinococcus granulosus Niemann Pick C1 protein 0.0159 0.0858 0.2221
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.1593 1
Onchocerca volvulus 0.0025 0.0074 0.0296
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0593 0.3399 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0052 0.006
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0052 0.006
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0235 0.0235
Plasmodium falciparum acyl-CoA synthetase 0.0055 0.0247 0.4875
Trypanosoma cruzi phosphomannose isomerase, putative 0.0095 0.048 0.1404
Schistosoma mansoni hypothetical protein 0.0031 0.0108 0.0278
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0135 0.0135
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0001 0.00000000027661
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0464 0.151
Brugia malayi Niemann-Pick C1 protein precursor 0.0111 0.0578 0.188
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0094 0.0474 0.0474
Echinococcus multilocularis Niemann Pick C1 protein 0.0159 0.0858 0.0858
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0135 0.0437
Trypanosoma cruzi DNA polymerase kappa, putative 0.0116 0.0607 0.1779
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0135 0.0437
Schistosoma mansoni cpg binding protein 0.0064 0.03 0.0774
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0059 0.1148
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.049 0.1592
Brugia malayi CHD4 protein 0.0016 0.0021 0.0066
Onchocerca volvulus 0.0013 0.0001 0.0000000291
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0001 0.00000000027661
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0205 0.0205
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0065 0.0182
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0066 0.0184
Leishmania major phosphomannose isomerase 0.0095 0.048 0.1404
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0064 0.0177
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0089 0.0253
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0052 0.006
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0059 0.0163
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0026 0.0067
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0355 0.1036
Trypanosoma brucei chrX additional, unordered contigs 0.0028 0.0089 0.0253
Onchocerca volvulus 0.0233 0.1291 0.5262
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0015 0.0015
Onchocerca volvulus 0.0432 0.2452 1
Echinococcus multilocularis Chromo domain 0.0013 0.0001 0.0001
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0015 0.0229
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0464 0.151
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0099 0.0505 0.1642
Schistosoma mansoni hypothetical protein 0.0031 0.0108 0.0278
Schistosoma mansoni DNA polymerase eta 0.014 0.0746 0.193
Entamoeba histolytica phosphomannose isomerase, putative 0.0095 0.048 0.301
Schistosoma mansoni hypothetical protein 0.0081 0.0398 0.1028
Schistosoma mansoni cpg binding protein 0.0061 0.028 0.0722
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0135 0.0387
Entamoeba histolytica hypothetical protein 0.0013 0.0001 0.00000000027661
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0052 0.0052
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0064 0.0177
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0094 0.0474 0.0474
Echinococcus granulosus tumor protein p63 0.0383 0.2165 0.5605
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0135 0.0842
Onchocerca volvulus 0.0022 0.0052 0.0207
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0056 0.0253 0.0822
Schistosoma mansoni hypothetical protein 0.0399 0.2259 0.5848
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1593 0.5188
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0015 0.0036
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0281 0.0728
Brugia malayi jmjC domain containing protein 0.0015 0.0015 0.0045
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.009 0.0453 0.1171
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0001 0.00000000011403
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0281 0.1569 0.4612
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.087 0.2831
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0073 0.0355 0.1154
Echinococcus multilocularis chromobox protein 1 0.0079 0.0387 0.0387
Echinococcus granulosus microtubule associated protein 2 0.0673 0.3862 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0164 0.0164
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0052 0.0165
Entamoeba histolytica deoxycytidyl transferase, putative 0.009 0.0453 0.2841
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.0717 0.2332
Brugia malayi chromobox protein homolog 3 0.0044 0.0184 0.0597
Loa Loa (eye worm) hypothetical protein 0.0025 0.0072 0.023
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0081 0.0398 0.0398
Brugia malayi hypothetical protein 0.0064 0.0302 0.0981
Trypanosoma brucei unspecified product 0.0062 0.0289 0.0842
Trichomonas vaginalis helicase, putative 0.0014 0.0006 0.0015
Schistosoma mansoni DNA helicase recq1 0.0018 0.0032 0.0081
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0272 0.0701
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0112 0.1817
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0081 0.0398 0.103
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0051 0.0226 0.0619
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0052 0.0142
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.049 0.049
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0055 0.0247 0.471
Brugia malayi polk-prov protein 0.0054 0.0243 0.079
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0098 0.16
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0052 0.0142
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.074 0.2263
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0083 0.0414 0.1209
Echinococcus multilocularis cpg binding protein 0.0064 0.03 0.03
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0355 0.1032
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.0355 0.1032

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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