Detailed information for compound 867393

Basic information

Technical information
  • TDR Targets ID: 867393
  • Name: N-(4-methoxyphenyl)-2-[6-(4-methylpiperidin-1 -yl)sulfonyl-3-oxo-1,4-benzothiazin-4-yl]acet amide
  • MW: 489.608 | Formula: C23H27N3O5S2
  • H donors: 1 H acceptors: 4 LogP: 2.9 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)CN1C(=O)CSc2c1cc(cc2)S(=O)(=O)N1CCC(CC1)C
  • InChi: 1S/C23H27N3O5S2/c1-16-9-11-25(12-10-16)33(29,30)19-7-8-21-20(13-19)26(23(28)15-32-21)14-22(27)24-17-3-5-18(31-2)6-4-17/h3-8,13,16H,9-12,14-15H2,1-2H3,(H,24,27)
  • InChiKey: BWGSLFVNXZCITM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-methoxyphenyl)-2-[6-[(4-methyl-1-piperidyl)sulfonyl]-3-oxo-1,4-benzothiazin-4-yl]acetamide
  • N-(4-methoxyphenyl)-2-[6-[(4-methyl-1-piperidinyl)sulfonyl]-3-oxo-1,4-benzothiazin-4-yl]acetamide
  • 2-[3-keto-6-[(4-methyl-1-piperidyl)sulfonyl]-1,4-benzothiazin-4-yl]-N-(4-methoxyphenyl)acetamide
  • N-(4-methoxyphenyl)-2-[6-(4-methylpiperidin-1-yl)sulfonyl-3-oxo-1,4-benzothiazin-4-yl]ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0139 0.0139
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0036 0.0036
Echinococcus granulosus serotonin receptor 0.0012 0.0015 0.0011
Schistosoma mansoni biogenic amine receptor 0.0012 0.0015 0.0015
Leishmania major trypanothione reductase 0.005 0.0114 0.0114
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0008 0.0004 0.0908
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Brugia malayi CXXC zinc finger family protein 0.0035 0.0073 0.0073
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.028 0.8933
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0029 0.0029
Brugia malayi RE15519p 0.0012 0.0015 0.0015
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0029 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0015 0.0015
Echinococcus multilocularis g-protein coupled receptor 0.0012 0.0015 0.0011
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0029 0.2536
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0015 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0015 0.0011
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0008 0.0004 0.0908
Echinococcus granulosus geminin 0.0358 0.0905 0.0902
Schistosoma mansoni hypothetical protein 0.0358 0.0905 0.0905
Schistosoma mansoni amine GPCR 0.0012 0.0015 0.0015
Plasmodium falciparum transporter, putative 0.0026 0.005 0.44
Echinococcus multilocularis cpg binding protein 0.0037 0.0079 0.0075
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0035 0.0035
Echinococcus multilocularis GPCR, family 2 0.0019 0.0033 0.003
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0036 0.0036
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0015 0.0015
Onchocerca volvulus 0.0026 0.005 0.0035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Schistosoma mansoni amine GPCR 0.0012 0.0015 0.0015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0139 0.0139
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0029 0.0391
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.005 0.005
Onchocerca volvulus 0.0151 0.0373 0.0359
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0572 0.1457 0.1454
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0008 0.0004 0.0003
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0015 0.0011
Plasmodium falciparum amino acid transporter, putative 0.0026 0.005 0.44
Echinococcus granulosus g-protein coupled receptor 0.0012 0.0015 0.0011
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0026 0.005 0.0047
Schistosoma mansoni amine GPCR 0.0012 0.0015 0.0015
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0015 0.0011
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0114 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0036 0.0036
Brugia malayi ORL1-like opioid receptor 0.0012 0.0015 0.0015
Loa Loa (eye worm) melatonin receptor type 1A 0.0012 0.0015 0.0015
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0042 0.0038
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0015 0.0015
Brugia malayi glutathione reductase 0.005 0.0114 0.0113
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0015 0.0011
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0015 0.0011
Echinococcus multilocularis dna polymerase kappa 0.002 0.0036 0.0033
Schistosoma mansoni opsin-like receptor 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0029 0.2536
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Plasmodium vivax amine transporter, putative 0.0026 0.005 0.44
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.028 0.8933
Echinococcus granulosus serotonin transporter 0.0151 0.0373 0.037
Schistosoma mansoni DNA helicase recq5 0.0009 0.0008 0.0008
Echinococcus granulosus peptide allatostatin:somatostatin 0.0012 0.0015 0.0011
Brugia malayi AKH receptor 0.0012 0.0015 0.0015
Brugia malayi hypothetical protein 0.0247 0.0621 0.0621
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0033 0.0033
Brugia malayi Pre-SET motif family protein 0.0033 0.0068 0.0068
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0017 0.0017
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0063 0.5486
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0033 0.003
Schistosoma mansoni hypothetical protein 0.0008 0.0004 0.0004
Schistosoma mansoni amine GPCR 0.0012 0.0015 0.0015
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.0313 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0012 0.0015 0.0011
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0008 0.0004 0.0908
Trypanosoma brucei trypanothione reductase 0.005 0.0114 0.0114
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0004 0.00000000015515
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0029 0.0026
Plasmodium vivax SET domain protein, putative 0.0033 0.0068 0.5961
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0012 0.0015 0.0011
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0026 0.005 0.0047
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.0556 0.0556
Schistosoma mansoni cpg binding protein 0.0037 0.0079 0.0079
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0126 0.0126
Echinococcus granulosus neuropeptide s receptor 0.0012 0.0015 0.0011
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0008 0.0004 0.0908
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0062
Toxoplasma gondii cytochrome p450 superfamily protein 0.0008 0.0004 0.0209
Schistosoma mansoni DNA polymerase eta 0.002 0.0036 0.0036
Schistosoma mansoni myosin xvIII 0.0012 0.0015 0.0015
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0033 0.0033
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0063 0.0063
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0008 0.0004 0.0908
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0126 0.0126
Brugia malayi hypothetical protein 0.002 0.0035 0.0034
Brugia malayi GnHR receptor homolog 0.0012 0.0015 0.0015
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0114 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0008 0.2118
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0012 0.0015 0.0015
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.005 0.005
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0015 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0036
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0126 0.0126
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0008 0.0004 0.0908
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0063 0.0059
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.005
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0009 0.0006
Echinococcus granulosus neuropeptide receptor 0.0012 0.0015 0.0011
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0012 0.0015 0.0015
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0068 0.4333
Echinococcus granulosus tachykinin peptides receptor 99D 0.0012 0.0015 0.0011
Schistosoma mansoni neuropeptide receptor 0.0012 0.0015 0.0015
Leishmania major cytochrome p450-like protein 0.0008 0.0004 0.0003
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0015 0.0015
Toxoplasma gondii exonuclease III APE 0.002 0.0035 0.2213
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0035 0.0483
Brugia malayi cytochrome P450 0.0008 0.0004 0.0003
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0019 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0033 0.003
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0035 0.963
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0026 0.005 0.0047
Echinococcus granulosus dro:myosuppressin receptor 0.0012 0.0015 0.0011
Echinococcus granulosus vesicular acetylcholine transporter 0.3891 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0012 0.0015 0.0015
Echinococcus multilocularis sex peptide receptor 0.0012 0.0015 0.0011
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0026 0.005 0.005
Brugia malayi sulfakinin receptor protein 0.0012 0.0015 0.0015
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0036 0.0036
Brugia malayi Tachykinin-like peptides receptor 99D 0.0012 0.0015 0.0015
Echinococcus multilocularis neuropeptide FF receptor 2 0.0012 0.0015 0.0011
Echinococcus multilocularis serotonin receptor 0.0012 0.0015 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0015 0.0015
Schistosoma mansoni adenoreceptor 0.0012 0.0015 0.0015
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0015 0.0011
Schistosoma mansoni sodium-dependent amino acid transporter 0.0026 0.005 0.005
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0029 0.0029
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0008 0.0487
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0033 0.003
Schistosoma mansoni cpg binding protein 0.0037 0.0079 0.0079
Echinococcus granulosus G protein coupled receptor 139 0.0012 0.0015 0.0011
Plasmodium vivax glutathione reductase, putative 0.005 0.0114 1
Schistosoma mansoni histamine h1 receptor 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Echinococcus granulosus neuropeptide receptor A26 0.0012 0.0015 0.0011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0029 0.0029
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0012 0.0015 0.0015
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.028 0.8933
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Echinococcus multilocularis serotonin transporter 0.0151 0.0373 0.037
Loa Loa (eye worm) hypothetical protein 0.1972 0.506 0.506
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.3857 0.9914 0.9914
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0015 0.0011
Schistosoma mansoni hypothetical protein 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0029 0.802
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.003 0.003
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0015 0.0015
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0012 0.0015 0.0015
Brugia malayi Pre-SET motif family protein 0.0222 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0035 0.3045
Echinococcus granulosus g protein coupled receptor 0.0012 0.0015 0.0011
Leishmania major C-8 sterol isomerase-like protein 0.3857 0.9914 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0008 0.0004 0.0908
Onchocerca volvulus 0.0033 0.0068 0.0053
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0015 0.0011
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0253 0.0635 0.0634
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0004 0.00000000015515
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0015 0.0011
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0015 0.0011
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0036 1
Echinococcus granulosus neuropeptide receptor 0.0012 0.0015 0.0011
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.005 0.005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0035 0.0031
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0029 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0036
Plasmodium falciparum glutathione reductase 0.0017 0.0029 0.2536
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0008 0.067
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0036 0.0033
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0035 0.1012
Loa Loa (eye worm) glutathione reductase 0.005 0.0114 0.0113
Schistosoma mansoni opsin-like receptor 0.0012 0.0015 0.0015
Schistosoma mansoni cytochrome P450 0.0008 0.0004 0.0004
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0015 0.0011
Echinococcus multilocularis neuropeptide s receptor 0.0012 0.0015 0.0011
Brugia malayi hypothetical protein 0.0012 0.0015 0.0015
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0008 0.0004 0.0908
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0036 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0008 0.0004 0.0908
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0012 0.0015 0.0015
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0015 0.0011
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0029 0.0029
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0029 0.1843
Echinococcus multilocularis neuropeptide receptor A26 0.0012 0.0015 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0036
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0008 0.0004 0.0003
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0042 0.0591
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.005
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Brugia malayi hypothetical protein 0.0012 0.0015 0.0015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0004 0.00000000015515
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0015 0.0011
Brugia malayi putative neuropeptide receptor NPR1 0.0012 0.0015 0.0015
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0035 0.0035
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0015 0.0011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0029 0.0029
Schistosoma mansoni vesicular acetylcholine transporter 0.3891 1 1
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0114 0.0113
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0015 0.0166
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0151 0.0373 0.0373
Schistosoma mansoni neuropeptide receptor 0.0012 0.0015 0.0015
Echinococcus granulosus 7tm_1 domain containing protein 0.0012 0.0015 0.0011
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0008
Onchocerca volvulus 0.005 0.0114 0.0099
Mycobacterium tuberculosis Probable reductase 0.0115 0.028 0.8933
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0015 0.0015
Brugia malayi hypothetical protein 0.0012 0.0015 0.0015
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0008 0.0004 0.0908
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.0621 0.0618
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0036
Schistosoma mansoni amine GPCR 0.0012 0.0015 0.0015
Trypanosoma brucei C-8 sterol isomerase, putative 0.3857 0.9914 1
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0015 0.0011
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0008 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0036 0.0036
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0015 0.0015
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0026 0.005 0.005
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0063 0.5486
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0015 0.0011
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0026 0.005 0.0047
Schistosoma mansoni ap endonuclease 0.002 0.0035 0.0035
Echinococcus multilocularis dro:myosuppressin receptor 0.0012 0.0015 0.0011
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0015 0.0011
Schistosoma mansoni cpg binding protein 0.0035 0.0073 0.0073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0015 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0068 0.0068
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0029 0.0029
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0004 0.00000000015515
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Brugia malayi Dopamine receptor 0.0012 0.0015 0.0015
Plasmodium falciparum thioredoxin reductase 0.0017 0.0029 0.2536
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0041 0.009 0.009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0015 0.0015
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0019 0.0016
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0012 0.0015 0.0011
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.005 0.3199
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0156 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.005 0.005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0015 0.0011
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0151 0.0373 0.0373
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.005 0.3199
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0008 0.0004 0.0908
Leishmania major cytochrome p450-like protein 0.0008 0.0004 0.0003
Echinococcus multilocularis sodium and chloride dependent glycine 0.0026 0.005 0.0047
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0004 0.00000000015515
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0004 0.00000000015515
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0126 0.0123
Brugia malayi G-protein coupled receptor 0.0012 0.0015 0.0015
Echinococcus granulosus fmrfamide receptor 0.0012 0.0015 0.0011
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0068 0.0064
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0015 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0036
Echinococcus granulosus tm gpcr rhodopsin 0.0572 0.1457 0.1454
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0036 0.0504
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0029 0.2536
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0114 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0036 0.0036
Brugia malayi Cytochrome P450 family protein 0.0008 0.0004 0.0003
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0026 0.005 1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.3857 0.9914 0.9914
Brugia malayi hypothetical protein 0.0012 0.0015 0.0015
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0033 0.003
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0033
Loa Loa (eye worm) serotonin transporter b 0.0151 0.0373 0.0373
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.005
Echinococcus granulosus alpha 1A adrenergic receptor 0.0012 0.0015 0.0011
Trypanosoma cruzi cytochrome P450, putative 0.0008 0.0004 0.0003
Leishmania major DNA polymerase kappa, putative 0.002 0.0036 0.0036
Schistosoma mansoni sodium/chloride dependent transporter 0.0026 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Echinococcus multilocularis allatostatin A receptor 0.0012 0.0015 0.0011
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0026 0.005 0.005
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.005 0.005
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.005 0.005
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0008 0.0008
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0012 0.0015 0.0015
Brugia malayi hypothetical protein 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.005 0.3199
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.028 0.8933
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0036 0.1055
Schistosoma mansoni biogenic amine receptor 0.0012 0.0015 0.0015
Echinococcus granulosus neuropeptide FF receptor 2 0.0012 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0026 0.005 0.005
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0015 0.0011
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0114 0.0114
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0029 0.0026
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0009 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0012 0.0015 0.0015
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0012 0.0015 0.0011
Brugia malayi G-protein coupled receptor 0.0012 0.0015 0.0015
Echinococcus multilocularis orexin receptor type 2 0.0012 0.0015 0.0011
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0035 0.0168
Trypanosoma brucei unspecified product 0.002 0.0036 0.0036
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0029 0.2536
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0008 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0151 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Schistosoma mansoni alpha-1 adrenergic receptor 0.0012 0.0015 0.0015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0015 0.0011
Loa Loa (eye worm) norepinephrine transporter 0.0151 0.0373 0.0373
Onchocerca volvulus 0.0026 0.005 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0036
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0015 0.0015
Onchocerca volvulus 0.0253 0.0635 0.0621
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0068 0.0064
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0004 0.00000000015515
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0036 0.0036
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0012 0.0015 0.0015
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0015 0.0011
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0035 0.303
Echinococcus granulosus dnaJ subfamily B 0.0494 0.1256 0.1253
Plasmodium vivax hypothetical protein, conserved 0.0026 0.005 0.44
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0035 0.0035
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0035 0.0035
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0151 0.0373 0.0373
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0126 0.0123
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0015 0.0015
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0015 0.0011
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0063 0.0063
Brugia malayi G protein-coupled receptor F59B2.13 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0009 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0015 0.0015
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0035 0.0035
Brugia malayi hypothetical protein 0.0012 0.0015 0.0015
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0012 0.0015 0.0011
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0008 0.0004 0.0908
Schistosoma mansoni hypothetical protein 0.0041 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0036 0.0036
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0012 0.0015 0.0015
Echinococcus granulosus somatostatin receptor 0.0012 0.0015 0.0011
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0012 0.0015 0.0011
Trypanosoma cruzi cytochrome P450, putative 0.0008 0.0004 0.0003
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.3891 1 1
Brugia malayi hypothetical protein 0.0026 0.005 0.005
Brugia malayi larval opioid receptor 0.0012 0.0015 0.0015
Echinococcus granulosus 7TM GPCR rhodopsin 0.0012 0.0015 0.0011
Echinococcus granulosus cpg binding protein 0.0037 0.0079 0.0075
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0015 0.0011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0126 0.0123
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.005
Brugia malayi Cytochrome P450 family protein 0.0008 0.0004 0.0003
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0023 0.2005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0068 0.0068
Echinococcus granulosus bloom syndrome protein 0.0022 0.0042 0.0038
Trypanosoma brucei cytochrome P450, putative 0.0008 0.0004 0.0003
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0012 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.005
Brugia malayi Cytochrome P450 family protein 0.0008 0.0004 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0029 0.0029
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0004 0.0003
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.028 0.8933
Brugia malayi G protein-coupled receptor 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0008 0.0004 0.0003
Echinococcus granulosus sex peptide receptor 0.0012 0.0015 0.0011
Toxoplasma gondii hypothetical protein 0.0026 0.005 0.3199
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0015 0.0011
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0035 0.9377
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0026 0.005 0.005
Brugia malayi Thioredoxin reductase 0.005 0.0114 0.0113
Leishmania major DNA polymerase eta, putative 0.002 0.0036 0.0036
Echinococcus multilocularis geminin 0.0358 0.0905 0.0902
Treponema pallidum sodium- and chloride- dependent transporter 0.0151 0.0373 1
Trichomonas vaginalis set domain proteins, putative 0.0253 0.0635 1
Brugia malayi neuropeptide F receptor 0.0012 0.0015 0.0015
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.0621 0.0618
Schistosoma mansoni neuropeptide f receptor 76f 0.0012 0.0015 0.0015
Echinococcus granulosus dna polymerase eta 0.002 0.0036 0.0033
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0008 0.0004 0.0908
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0004 0.00000000015515
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.3891 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0015 0.0011
Echinococcus granulosus GPCR family 2 0.0019 0.0033 0.003
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0029 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0126 0.0123
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0035 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.0313 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0036 0.0504
Brugia malayi Dopamine receptor protein 2 0.0012 0.0015 0.0015
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0012 0.0015 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0015 0.0015
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0035 0.0031
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0015 0.0015
Echinococcus multilocularis somatostatin receptor 0.0012 0.0015 0.0011
Schistosoma mansoni survival motor neuron protein 0.005 0.0114 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0014 0.0019 0.0019
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0036 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.002 0.002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0035 0.963
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0029 0.0029
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0015 0.0015
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0026 0.005 0.0047
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0114 0.3564
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0012 0.0015 0.0011
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0029 0.0825
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0029 0.0029
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0029 0.0029
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0177 0.0177
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0029 0.0029
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.006 0.0139 0.0139
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0008 0.0008
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0008 0.0008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0035 0.0035
Trypanosoma brucei unspecified product 0.0014 0.002 0.002
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0008 0.0004 0.0908
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0033 0.0033
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0012 0.0015 0.0011
Schistosoma mansoni growth hormone secretagogue receptor 0.0012 0.0015 0.0015
Brugia malayi follicle stimulating hormone receptor 0.0253 0.0635 0.0634
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0008 0.0004 0.0908
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.002 0.002
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0035 0.3045
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0015 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0247 0.0621 0.0621
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0023 0.1428
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.005 0.005
Leishmania major cytochrome p450-like protein 0.0008 0.0004 0.0003
Schistosoma mansoni biogenic amine receptor 0.0012 0.0015 0.0015
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0014 0.0014
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.0313 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0008 0.0004 0.0908
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0029 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0068 0.0068
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0015 0.0015
Trypanosoma cruzi C-8 sterol isomerase, putative 0.3857 0.9914 1
Brugia malayi hypothetical protein 0.0012 0.0015 0.0015
Schistosoma mansoni DNA helicase recq1 0.0009 0.0008 0.0008
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0029 0.802
Onchocerca volvulus 0.0035 0.0073 0.0059
Schistosoma mansoni opsin-like receptor 0.0012 0.0015 0.0015
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0012 0.0015 0.0011
Schistosoma mansoni sodium/chloride dependent transporter 0.0151 0.0373 0.0373
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0015 0.0011
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0029 0.0029
Brugia malayi Serotonin receptor 0.0012 0.0015 0.0015
Brugia malayi hypothetical protein 0.003 0.0063 0.0062
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.005
Loa Loa (eye worm) TYRA-2 protein 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0494 0.1256 0.1256
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0015 0.0015
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0015 0.0014
Plasmodium falciparum glutathione reductase 0.005 0.0114 1
Echinococcus granulosus g protein coupled receptor 0.0012 0.0015 0.0011
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0035 0.0483
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0008 0.0004
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0008 0.0004 0.0908
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0151 0.0373 0.0373
Loa Loa (eye worm) CYP4Cod1 0.0008 0.0004 0.0003
Brugia malayi putative neuropeptide receptor 0.0012 0.0015 0.0015
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0036 0.0036
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0036 0.1055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0015 0.0015
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Schistosoma mansoni ap endonuclease 0.002 0.0035 0.0035
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0012 0.0015 0.0015
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0015 0.0011
Brugia malayi Melatonin receptor type 1A 0.0012 0.0015 0.0015
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0008 0.0004 0.0908
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0029 0.802
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0042 0.0591
Schistosoma mansoni hypothetical protein 0.005 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.003
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0008 0.0004 0.0908
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0008 0.0004 0.0908
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0036 0.0036
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0063 0.5486
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0012 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0012 0.0015 0.0015
Brugia malayi neuropeptide F receptor 0.0012 0.0015 0.0015
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0015 0.0011
Echinococcus multilocularis sodium and chloride dependent glycine 0.0026 0.005 0.0047
Echinococcus multilocularis serotonin receptor 0.0012 0.0015 0.0011
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0036
Toxoplasma gondii thioredoxin reductase 0.005 0.0114 0.727
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0015 0.0015
Loa Loa (eye worm) RecQ helicase 0.0022 0.0042 0.0041
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0015 0.0015
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Echinococcus multilocularis G-protein coupled receptor, putative 0.0012 0.0015 0.0011
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0033
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.028 0.8933
Echinococcus granulosus sodium and chloride dependent glycine 0.0026 0.005 0.0047
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0029 0.0391
Brugia malayi Cytochrome P450 family protein 0.0008 0.0004 0.0003
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0015 0.0015
Brugia malayi hypothetical protein 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Giardia lamblia DINP protein human, muc B family 0.002 0.0036 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0068 0.0064
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0042 0.0041
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0012 0.0015 0.0015
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0063 0.3988
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0029 0.0029
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0015 0.0011
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0026 0.005 0.0047
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0008 0.0004 0.0908
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0026 0.005 0.0047
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0015 0.0015
Echinococcus granulosus orexin receptor type 2 0.0012 0.0015 0.0011
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0036 0.0036
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0063 0.0063
Loa Loa (eye worm) cytochrome P450 0.0008 0.0004 0.0003
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0012 0.0015 0.0015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0015 0.0011
Brugia malayi hypothetical protein 0.0012 0.0015 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Brugia malayi Serotonin receptor 0.0012 0.0015 0.0015
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0029 0.802
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0015 0.0011
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0036 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.0313 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0015 0.0011
Echinococcus multilocularis vesicular acetylcholine transporter 0.3891 1 1
Echinococcus granulosus g protein coupled receptor 0.0012 0.0015 0.0011
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0114 0.0114
Trypanosoma brucei unspecified product 0.0014 0.002 0.002
Echinococcus multilocularis dna polymerase eta 0.002 0.0036 0.0033
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0008 0.0004 0.0003
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0029 0.1843
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0008 0.0487
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Toxoplasma gondii hypothetical protein 0.0026 0.005 0.3199
Echinococcus granulosus hypothetical protein 0.0012 0.0015 0.0011
Loa Loa (eye worm) solute carrier family 6 member 4 0.0151 0.0373 0.0373
Echinococcus granulosus allatostatin A receptor 0.0012 0.0015 0.0011
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0029 0.0029
Echinococcus granulosus sodium and chloride dependent glycine 0.0026 0.005 0.0047
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0009 0.0006
Onchocerca volvulus 0.0026 0.005 0.0035
Schistosoma mansoni hypothetical protein 0.0012 0.0015 0.0015
Echinococcus granulosus dna polymerase kappa 0.002 0.0036 0.0033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0126 0.0126
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0068 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0036
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.1256 0.1253
Echinococcus multilocularis G protein coupled receptor 139 0.0012 0.0015 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0015 0.0011
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0004 0.0003
Schistosoma mansoni neuropeptide receptor 0.0012 0.0015 0.0015
Brugia malayi Dopamine receptor protein 1 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0068
Leishmania major hypothetical protein, conserved 0.003 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Schistosoma mansoni sodium/chloride dependent transporter 0.0026 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0358 0.0905 0.0905
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0073 0.0073
Brugia malayi hypothetical protein 0.0012 0.0015 0.0015
Plasmodium falciparum thioredoxin reductase 0.005 0.0114 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0008 0.0004
Schistosoma mansoni neuropeptide receptor 0.0012 0.0015 0.0015
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0012 0.0015 0.0015

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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