Detailed information for compound 88474

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 263.377 | Formula: C19H21N
  • H donors: 0 H acceptors: 0 LogP: 4.11 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(N1CC2c3c(CC1c1c2cccc1)cccc3)C
  • InChi: 1S/C19H21N/c1-13(2)20-12-18-15-8-4-3-7-14(15)11-19(20)17-10-6-5-9-16(17)18/h3-10,13,18-19H,11-12H2,1-2H3
  • InChiKey: KGILZEYELXMKRP-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Glutamate NMDA receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0014 0.0037 0.0969
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0014 0.0037 0.0096
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1797 0.6401
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0567 0.099
Echinococcus granulosus zinc finger protein 0.0019 0.0091 0.0126
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0014 0.0037 0.0002
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0083 0.5
Leishmania major hypothetical protein, conserved 0.0036 0.0286 0.0876
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0064 0.0088
Echinococcus granulosus nervana 2 0.008 0.079 0.1094
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0163 0.2814
Brugia malayi RNA, U transporter 1 0.0172 0.1832 0.3426
Mycobacterium leprae Probable lipase LipE 0.0036 0.0286 0.0428
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0286 0.0998
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0062 0.0579 0.2047
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0016 0.0058 0.008
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0567 0.0964
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0567 0.0964
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0286 0.0436
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1797 0.6401
Echinococcus multilocularis caspase 8 0.0062 0.0579 0.0579
Onchocerca volvulus 0.002 0.01 0.0105
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0016 0.0053 0.0053
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0005 0.0007
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0014 0.0037 0.0096
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0014 0.0037 0.064
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0328 0.0454
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0036 0.0094
Brugia malayi Bromodomain containing protein 0.0037 0.0297 0.0555
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.007 0.0097
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0328 0.1148
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0032 0.0239 0.0239
Schistosoma mansoni importin-beta 2 0.0011 0.0006 0.0009
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0077 0.1322
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0016 0.0053 0.0148
Trypanosoma brucei metacaspase MCA2 0.0062 0.0579 0.1797
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.008 0.079 0.1094
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0286 0.0443
Mycobacterium leprae Isocitrate lyase 0.0085 0.084 0.147
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.0383 0.0383
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0271 0.0375
Brugia malayi beta-lactamase family protein 0.0036 0.0286 0.0534
Trypanosoma brucei glucosidase, putative 0.004 0.0328 0.1008
Trypanosoma brucei metacaspase 5, putative 0.0062 0.0579 0.1797
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0286 0.0876
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0016 0.0053 0.0054
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0271 0.0271
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0124 0.0124
Plasmodium falciparum calcium-transporting ATPase 0.0016 0.0053 0.0924
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0647 0.7219 1
Brugia malayi Pre-SET motif family protein 0.0208 0.2243 0.4193
Schistosoma mansoni importin beta-1 0.0061 0.0564 0.0781
Brugia malayi Na,K-ATPase alpha subunit 0.0041 0.0342 0.064
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0061
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0016 0.0053 0.0924
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.0181 0.1932 0.3646
Onchocerca volvulus 0.0104 0.1053 0.1901
Schistosoma mansoni hypothetical protein 0.0354 0.3891 0.5389
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0567 0.0567
Trypanosoma brucei metacaspase 0.0062 0.0579 0.1797
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0016 0.0053 0.0054
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0044 0.0136
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.004 0.0326 0.0512
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0014 0.0037 0.011
Mycobacterium ulcerans isocitrate lyase Icl 0.0181 0.1932 0.3527
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0176 0.0606
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0067 0.0632 0.0876
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0083 0.0115
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0044 0.0136
Trypanosoma brucei calcium-translocating P-type ATPase 0.0016 0.0053 0.0148
Brugia malayi Bromodomain containing protein 0.0073 0.07 0.1309
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0016 0.0058 0.0899
Echinococcus multilocularis nmda type glutamate receptor 0.0032 0.0239 0.0239
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0014 0.0037 0.0002
Echinococcus granulosus calcium transporting atpase 0.0016 0.0053 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1797 0.6401
Loa Loa (eye worm) hypothetical protein 0.008 0.079 0.1094
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0286 0.0396
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0328 0.1491
Onchocerca volvulus 0.0067 0.0632 0.1108
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0035 0.0278 0.052
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0567 0.0785
Echinococcus multilocularis GPCR, family 2 0.0015 0.005 0.005
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0016 0.0053 0.0074
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.002 0.0099 0.0138
Echinococcus granulosus importin subunit beta 1 0.0061 0.0564 0.0781
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0036 0.0107
Echinococcus granulosus snurportin 1 0.0647 0.7219 1
Brugia malayi beta-lactamase 0.0036 0.0286 0.0534
Schistosoma mansoni ATPase 0.0014 0.0037 0.0051
Plasmodium falciparum cysteine repeat modular protein 1 0.002 0.01 0.1732
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.0383 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0023 0.0137 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0062 0.0579 0.2047
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0396
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0041 0.0342 0.0474
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.148 0.205
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0564 0.175
Mycobacterium ulcerans isocitrate lyase AceAb 0.0181 0.1932 0.3527
Brugia malayi follicle stimulating hormone receptor 0.0231 0.2502 0.4677
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0114
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0567 0.0785
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0396
Echinococcus granulosus geminin 0.0354 0.3891 0.5389
Trypanosoma cruzi ISWI complex protein 0.0015 0.0044 0.0025
Trypanosoma brucei metacaspase MCA3 0.0062 0.0579 0.1797
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0286 0.079
Trichomonas vaginalis cation-transporting ATPase, putative 0.0014 0.0037 0.011
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0062 0.0579 0.1082
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0286 0.0534
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0083 0.0273
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0163 0.0401
Brugia malayi PHD-finger family protein 0.0024 0.015 0.028
Onchocerca volvulus 0.008 0.079 0.1406
Plasmodium falciparum metacaspase-like protein 0.0062 0.0579 1
Loa Loa (eye worm) hypothetical protein 0.0482 0.5348 0.7408
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0424 0.0587
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0286 0.0998
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0286 0.0443
Schistosoma mansoni hypothetical protein 0.002 0.01 0.0139
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0062 0.0579 0.2047
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0567 0.0964
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.0469 0.5196 1
Onchocerca volvulus 0.0082 0.0812 0.1447
Brugia malayi hypothetical protein 0.0482 0.5348 1
Onchocerca volvulus 0.002 0.0099 0.0104
Echinococcus multilocularis snurportin 1 0.0647 0.7219 0.7219
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0134 0.1403 0.1403
Schistosoma mansoni hypothetical protein 0.002 0.0103 0.0143
Echinococcus granulosus transportin 1 0.0011 0.0006 0.0009
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0564 0.175
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0016 0.0053 0.0074
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0051
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0286 0.0998
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0016 0.0058 0.008
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1446 0.4466
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0016 0.0058 0.1512
Schistosoma mansoni lozenge 0.006 0.0563 0.0779
Trypanosoma cruzi metacaspase, putative 0.0062 0.0579 0.1719
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.2804 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0342 0.0474
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0016 0.0058 0.0161
Mycobacterium ulcerans hypothetical protein 0.0154 0.1623 0.2949
Echinococcus granulosus nervana 2 0.008 0.079 0.1094
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0062 0.0579 0.2047
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0014 0.003 0.003
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0297 0.1038
Trypanosoma brucei Metacaspase-4 0.0062 0.0579 0.1797
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0016 0.0053 0.0074
Echinococcus multilocularis nervana 2 0.008 0.079 0.079
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0434 0.1529
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0083 0.2165
Loa Loa (eye worm) runx1 0.006 0.0563 0.0779
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0062 0.0579 0.2047
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0062 0.0579 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0812 0.1124
Loa Loa (eye worm) TK/ROR protein kinase 0.002 0.01 0.0139
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.2502 0.3465
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0134 0.1403 0.1944
Onchocerca volvulus 0.0036 0.0286 0.0455
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0062 0.0579 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.005 0.0069
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0297 0.0411
Loa Loa (eye worm) hypothetical protein 0.0144 0.1514 0.2098
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0286 0.4878
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.0181 0.1932 0.3646
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.19 0.6771
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0014 0.0037 0.0002
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0035 0.0278 0.0385
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0044 0.0136
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.008 0.079 0.1094
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0203 0.0281
Echinococcus multilocularis calcium transporting atpase 0.0016 0.0053 0.0053
Brugia malayi Kringle domain containing protein 0.002 0.01 0.0187
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.3193 1
Schistosoma mansoni transmemberane protein 0.008 0.079 0.1094
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.0006 0.0009
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0297 0.0911
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0532 0.0737
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0124 0.0172
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0014 0.003 0.0042
Echinococcus granulosus caspase 2 0.0144 0.1514 0.2098
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.005 0.0069
Loa Loa (eye worm) hypothetical protein 0.0037 0.0297 0.0411
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0083 0.0147
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0216 0.0299
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.002 0.0099 0.0332
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0083 0.0115
Entamoeba histolytica Ran family GTPase 0.0045 0.0383 0.1746
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.0006 0.0009
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.0006 0.011
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0061
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0014 0.003 0.0042
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0014 0.0037 0.011
Loa Loa (eye worm) RecQ helicase 0.0026 0.0176 0.0244
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0083 0.1431
Onchocerca volvulus 0.002 0.0099 0.0104
Trypanosoma brucei ISWI complex protein 0.0015 0.0044 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0579 0.2047
Trypanosoma cruzi metacaspase, putative 0.0062 0.0579 0.1719
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0016 0.0058 0.0999
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0064 0.0088
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0286 0.0443
Schistosoma mansoni ap endonuclease 0.0018 0.0083 0.0115
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0083 0.0273
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0579 1
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0016 0.0058 0.0999
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0041 0.0342 0.0474
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0176 0.0606
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0163 0.2734
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.148 0.205
Schistosoma mansoni caspase-7 (C14 family) 0.0144 0.1514 0.2098
Echinococcus granulosus Na:K ATPase alpha subunit 0.0041 0.0342 0.0474
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0083 0.0055
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0044 0.0025
Schistosoma mansoni alpha-glucosidase 0.0154 0.1627 0.2254
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.01 0.0139
Onchocerca volvulus Cell death protein 3 homolog 0.0144 0.1514 0.2771
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0023 0.0137 0.0157
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0016 0.0058 0.0239
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0016 0.0053 0.0219
Onchocerca volvulus 0.004 0.0326 0.0531
Entamoeba histolytica hypothetical protein 0.0049 0.0434 0.1985
Leishmania major calcium-transporting ATPase, putative 0.0016 0.0053 0.0148
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0201 0.2161 0.7701
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0343 0.097
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.0016 0.0058 0.0008
Loa Loa (eye worm) hypothetical protein 0.0133 0.1385 0.1918
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0286 0.0396
Echinococcus granulosus nervana 2 0.0067 0.0632 0.0876
Toxoplasma gondii kringle domain-containing protein 0.002 0.01 0.1732
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0083 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1797 0.6401
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0403 0.0558
Brugia malayi MH2 domain containing protein 0.0131 0.1367 0.2555
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.0006 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0579 0.2047
Mycobacterium tuberculosis Conserved protein 0.0036 0.0286 0.0443
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0424 0.0792
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0297 0.0297
Toxoplasma gondii hypothetical protein 0.0047 0.0411 0.7104
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0297 0.0825
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.008 0.079 0.079
Leishmania major P-type ATPase, putative 0.0016 0.0053 0.0148
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0016 0.0053 0.0053
Brugia malayi Latrophilin receptor protein 2 0.0015 0.005 0.0093
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0023 0.0137 0.0155
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.002 0.0099 0.0332
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0579 0.2047
Echinococcus multilocularis importin subunit beta 1 0.0061 0.0564 0.0564
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0403 0.0403
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0083 0.024
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.0564 0.9745
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0014 0.0037 0.0096
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.19 0.6771
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.2243 0.3107
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0016 0.0053 0.0924
Leishmania major metacaspase, putative 0.0062 0.0579 0.1797
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0286 0.0443
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.0383 0.0715
Leishmania major calcium motive p-type ATPase, putative 0.0016 0.0053 0.0148
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0016 0.0058 0.0184
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0286 0.079
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0083 0.1335
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.0383 0.053
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0297 0.0411
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0064 0.0088
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0286 0.0998
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0062 0.0579 0.0802
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0328 0.1148
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0328 0.1491
Echinococcus granulosus nmda type glutamate receptor 0.0032 0.0239 0.0331
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0016 0.0053 0.0074
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0328 0.1148
Brugia malayi hypothetical protein 0.0025 0.0163 0.0305
Mycobacterium leprae PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) 0.0181 0.1932 0.3522
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.0383 0.6608
Echinococcus multilocularis geminin 0.0354 0.3891 0.3891
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.005 0.0069
Trypanosoma cruzi metacaspase, putative 0.0062 0.0579 0.1719
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0016 0.0058 0.0239
Echinococcus multilocularis Protein lozenge 0.006 0.0563 0.0563
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0014 0.0037 0.0096
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0079 0.1267
Schistosoma mansoni bromodomain containing protein 0.0061 0.0571 0.0791
Brugia malayi Importin beta-1 subunit 0.0061 0.0564 0.1055
Plasmodium falciparum transportin 0.0011 0.0006 0.011
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0083 0.0355
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.148 0.148
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0434 0.1529
Schistosoma mansoni hypothetical protein 0.0015 0.005 0.0069
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0201 0.2161 1
Brugia malayi Protein kinase domain containing protein 0.002 0.01 0.0187
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0328 0.1148
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0124 0.0172
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.002 0.0099 0.0099
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1446 0.4518
Plasmodium vivax P-type ATPase4, putative 0.0016 0.0053 0.0823
Leishmania major calcium-translocating P-type ATPase 0.0014 0.0037 0.0096
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0567 0.1758
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0103 0.0143
Mycobacterium tuberculosis Conserved protein 0.0036 0.0286 0.0443
Plasmodium vivax calcium-transporting ATPase, putative 0.0016 0.0053 0.0823
Schistosoma mansoni hypothetical protein 0.0033 0.0251 0.0347
Loa Loa (eye worm) hypothetical protein 0.0025 0.0165 0.0229
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0062 0.0579 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0297 0.0297
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0163 0.2814
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0383 0.1096
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0014 0.0037 0.011
Trichomonas vaginalis cdc25c, putative 0.002 0.0099 0.0332
Brugia malayi Pre-SET motif family protein 0.003 0.0216 0.0403
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0286 0.0428
Loa Loa (eye worm) hypothetical protein 0.008 0.079 0.1094
Schistosoma mansoni caspase-3 (C14 family) 0.0134 0.1403 0.1944
Echinococcus granulosus m phase inducer phosphatasecdc25 0.002 0.0099 0.0138
Trypanosoma cruzi metacaspase 5, putative 0.0062 0.0579 0.1719
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0014 0.0037 0.0142
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0014 0.0037 0.0142
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0297 0.1348
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0297 0.1038
Trichomonas vaginalis set domain proteins, putative 0.0237 0.257 0.9163
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0297 0.7758
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0016 0.0058 0.0108
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.0383 0.6608
Plasmodium falciparum importin beta, putative 0.0061 0.0564 0.9745
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0343 0.1055
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0328 0.0613
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0016 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0039 0.0324 0.0448
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0036 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0297 0.1038
Chlamydia trachomatis glutamine binding protein 0.0023 0.0137 0.5
Echinococcus granulosus lysosomal alpha glucosidase 0.0179 0.191 0.2646
Loa Loa (eye worm) hypothetical protein 0.0015 0.005 0.0069
Echinococcus granulosus apoptotic protease activating factor 1 0.0082 0.0812 0.1124
Mycobacterium ulcerans beta-lactamase 0.0036 0.0286 0.0436
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0023 0.0137 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0216 0.0216
Onchocerca volvulus 0.0036 0.0286 0.0455
Plasmodium vivax SET domain protein, putative 0.003 0.0216 0.3656
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0396
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.3193 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0014 0.003 0.0042
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0016 0.0053 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1797 0.6401
Brugia malayi beta-lactamase family protein 0.0036 0.0286 0.0534
Echinococcus multilocularis caspase 2 0.0144 0.1514 0.1514
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0328 0.1008
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0343 0.097
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.008 0.079 0.079
Schistosoma mansoni ap endonuclease 0.0018 0.0083 0.0115
Trichomonas vaginalis cation-transporting ATPase, putative 0.0014 0.0037 0.011
Loa Loa (eye worm) hypothetical protein 0.0482 0.5348 0.7408
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0014 0.0037 0.011
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0034 0.0262 0.0383
Mycobacterium tuberculosis Conserved protein 0.0036 0.0286 0.0443
Schistosoma mansoni alpha-glucosidase 0.0154 0.1627 0.2254
Loa Loa (eye worm) hypothetical protein 0.0062 0.0579 0.0802
Mycobacterium ulcerans hypothetical protein 0.0036 0.0286 0.0436
Plasmodium vivax cysteine repeat modular protein 1, putative 0.002 0.01 0.164
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.2492 0.4737
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0083 0.0049
Echinococcus multilocularis zinc finger protein 0.0019 0.0091 0.0091
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0036 0.0094
Brugia malayi Glycosyl hydrolases family 31 protein 0.0179 0.191 0.3572
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0328 0.0328
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0176 0.0176
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0343 0.097
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0067 0.0632 0.0876
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0044 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0328 0.0923
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0286 0.0998
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.148 0.205
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0396
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0044 0.0136
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0014 0.0037 0.0142
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.008 0.079 0.1094
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.0181 0.1932 0.3646
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0016 0.0053 0.0074
Onchocerca volvulus 0.0036 0.0286 0.0455
Brugia malayi Cell death protein 3 precursor 0.0144 0.1514 0.2831
Echinococcus multilocularis caspase 3 0.0073 0.0701 0.0701
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0286 0.0443
Echinococcus multilocularis glutamate receptor 2 0.0014 0.003 0.003
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0403 0.0558
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0044 0.0119
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0016 0.0058 0.0068
Onchocerca volvulus 0.002 0.0099 0.0104
Leishmania major hypothetical protein, conserved 0.0025 0.0163 0.0491
Plasmodium vivax importin-beta 2, putative 0.0061 0.0564 0.9742
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.148 0.148
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.148 0.205
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.005 0.0093
Echinococcus granulosus bloom syndrome protein 0.0026 0.0176 0.0244
Schistosoma mansoni zinc finger protein 0.0015 0.0044 0.0061
Loa Loa (eye worm) hypothetical protein 0.0032 0.0238 0.033
Schistosoma mansoni hypothetical protein 0.0011 0.0005 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0579 0.2047
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.002 0.0099 0.0332
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.2804 1
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0016 0.0058 0.008
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.191 0.191
Echinococcus multilocularis tissue type plasminogen activator 0.002 0.01 0.01
Schistosoma mansoni hypothetical protein 0.0354 0.3891 0.5389
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0014 0.0037 0.0969
Echinococcus multilocularis translational activator gcn1 0.0011 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0082 0.0812 0.1124
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0014 0.0037 0.0037
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0434 0.126
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0328 0.1148
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0579 0.2047
Onchocerca volvulus 0.0482 0.5348 1
Schistosoma mansoni hypothetical protein 0.0015 0.005 0.0069
Echinococcus granulosus importin 5 0.0011 0.0006 0.0009
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0297 0.0411
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0044 0.0136
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0014 0.0037 0.0096
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0014 0.0037 0.011
Loa Loa (eye worm) hypothetical protein 0.002 0.0099 0.0138
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.1367 0.1893
Trypanosoma cruzi metacaspase 5, putative 0.0062 0.0579 0.1719
Leishmania major hypothetical protein, conserved 0.0015 0.0044 0.0119
Schistosoma mansoni caspase-7 (C14 family) 0.0134 0.1403 0.1944
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0062 0.0579 0.2047
Schistosoma mansoni alpha glucosidase 0.004 0.0328 0.0454
Echinococcus multilocularis nervana 2 0.008 0.079 0.079
Entamoeba histolytica rodhanase-like domain containing protein 0.002 0.0099 0.0432
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0044 0.0136
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0328 0.0454
Loa Loa (eye worm) hypothetical protein 0.0048 0.0424 0.0587
Loa Loa (eye worm) hypothetical protein 0.0061 0.0564 0.0781
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0567 0.9789
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0067 0.0632 0.0632
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0328 0.1148
Loa Loa (eye worm) hypothetical protein 0.002 0.0099 0.0138
Loa Loa (eye worm) hypothetical protein 0.0028 0.0189 0.0261
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0016 0.0053 0.0074
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0216 0.3726
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0016 0.0053 0.0168
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0434 0.1529
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0258 0.2804 0.5242
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0041 0.0342 0.8953
Plasmodium falciparum metacaspase 1 0.0062 0.0579 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0044 0.0176
Brugia malayi Rhodanese-like domain containing protein 0.002 0.0099 0.0186
Loa Loa (eye worm) hypothetical protein 0.0037 0.0298 0.0412
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0014 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0015 0.005 0.0069
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0286 0.0396
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0216 0.0299
Schistosoma mansoni glutamate receptor NMDA 0.0014 0.003 0.0042
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0041 0.0342 0.0474
Echinococcus multilocularis nervana 2 0.0067 0.0632 0.0632
Echinococcus granulosus nervana 2 0.0067 0.0632 0.0876
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0067 0.0632 0.0876
Brugia malayi kap beta 3 protein 0.0011 0.0006 0.0012
Toxoplasma gondii ABC1 family protein 0.0036 0.0286 0.4935
Onchocerca volvulus 0.002 0.0099 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0579 0.2047
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0328 0.1148
Echinococcus granulosus tissue type plasminogen activator 0.002 0.01 0.0139
Echinococcus multilocularis nervana 2 0.0067 0.0632 0.0632
Plasmodium vivax metacaspase 1, putative 0.0062 0.0579 1
Trichomonas vaginalis ran, putative 0.0045 0.0383 0.1345
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0016 0.0053 0.0074
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.148 0.2767
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.3193 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.0383 0.053
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0424 0.0792
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0297 0.0297
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.0383 0.657
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0044 0.0136
Echinococcus multilocularis caspase 0.0134 0.1403 0.1403
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0041 0.0342 0.0342
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0286 0.0443
Brugia malayi hypothetical protein 0.0016 0.0061 0.0115
Brugia malayi hypothetical protein 0.0082 0.0812 0.1518
Brugia malayi Membrane calcium atpase protein 3 0.0016 0.0053 0.01
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0297 0.0825
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0083 0.024
Echinococcus granulosus caspase 8 0.0062 0.0579 0.0802
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0064 0.0064
Trichomonas vaginalis cdc25b, putative 0.002 0.0099 0.0332
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0396
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.005 0.005
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0251 0.0468
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0083 0.0147
Echinococcus granulosus caspase 0.0134 0.1403 0.1944
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0297 0.0911
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1623 0.3047
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.1797 0.3304
Toxoplasma gondii P-type ATPase4, putative 0.0016 0.0053 0.0924
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0383 0.1096
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1797 0.6401
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0014 0.003 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1797 0.6401
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0179 0.191 0.2646
Trichomonas vaginalis cation-transporting ATPase, putative 0.0014 0.0037 0.011
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0014 0.003 0.0042
Loa Loa (eye worm) hypothetical protein 0.0046 0.0403 0.0558
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0163 0.2814
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0286 0.0286
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0567 0.0785
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0328 0.1148
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.0485 0.5378 1
Mycobacterium leprae Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) 0.0485 0.5378 1
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.3193 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.005 0.005
Echinococcus granulosus translational activator gcn1 0.0011 0.0006 0.0009
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.002 0.0099 0.0332
Echinococcus multilocularis transportin 1 0.0011 0.0006 0.0006
Schistosoma mansoni ran 0.0045 0.0383 0.053
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0114
Schistosoma mansoni hypothetical protein 0.0015 0.005 0.0069
Brugia malayi Rhodanese-like domain containing protein 0.002 0.0099 0.0186
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0062 0.0579 0.2047
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.2804 1
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.1367 0.1893
Onchocerca volvulus 0.0237 0.257 0.4761
Schistosoma mansoni ran 0.0045 0.0383 0.053
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0328 0.1148
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0328 0.0923
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.148 0.205
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.008 0.079 0.1094
Entamoeba histolytica rodhanase-like domain containing protein 0.002 0.0099 0.0432
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0258 0.2804 0.3884
Echinococcus multilocularis apoptotic protease activating factor 1 0.0082 0.0812 0.0812
Trichomonas vaginalis esterase, putative 0.0036 0.0286 0.0998
Loa Loa (eye worm) hypothetical protein 0.0068 0.0653 0.0905
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.1446 0.4518
Toxoplasma gondii exonuclease III APE 0.0018 0.0083 0.1431
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0016 0.0053 0.0168
Entamoeba histolytica rodhanase-like domain containing protein 0.002 0.0099 0.0432
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0176 0.0329
Schistosoma mansoni ATPase 0.0014 0.0037 0.0051
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0016 0.0053 0.0074
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0016 0.0053 0.0053
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0044 0.0119
Echinococcus granulosus GPCR family 2 0.0015 0.005 0.0069
Trypanosoma cruzi metacaspase, putative 0.0062 0.0579 0.1719
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.008 0.079 0.079
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.2804 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0163 0.0401
Mycobacterium ulcerans lipase LipD 0.0036 0.0286 0.0436
Loa Loa (eye worm) hypothetical protein 0.0033 0.0251 0.0347
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0083 0.0155
Loa Loa (eye worm) hypothetical protein 0.0025 0.0163 0.0226
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.191 0.191
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0023 0.0137 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0044 0.0025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0286 0.0396
Schistosoma mansoni hypothetical protein 0.0647 0.7219 1
Leishmania major GTP-binding protein, putative 0.0045 0.0383 0.118
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0062 0.0579 0.2047
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0062 0.0579 0.2047
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0016 0.0058 0.0161
Leishmania major hypothetical protein, conserved 0.002 0.01 0.0295
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0297 0.0555
Echinococcus granulosus glutamate receptor 2 0.0014 0.003 0.0042
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0016 0.0053 0.01
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0163 0.0491
Echinococcus multilocularis importin 5 0.0011 0.0006 0.0006
Leishmania major importin beta-1 subunit, putative 0.0049 0.0434 0.1342
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0286 0.0436
Schistosoma mansoni zinc finger protein 0.0019 0.0091 0.0126
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0396
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0445 0.1293
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.014 0.2411
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0044 0.0136
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0014 0.003 0.003
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0016 0.0058 0.0058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.148 0.205
Trichomonas vaginalis cdc25b, putative 0.002 0.0099 0.0332
Trypanosoma cruzi ISWI complex protein 0.0015 0.0044 0.0025
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0297 0.0411
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0297 0.0411
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.2804 1
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.2804 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0345 0.0477
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0113 0.0156
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0403 0.0558
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0014 0.0037 0.0051
Onchocerca volvulus 0.003 0.0216 0.0323
Loa Loa (eye worm) beta-lactamase 0.0036 0.0286 0.0396
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0016 0.0053 0.0924
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.01 0.0202
Echinococcus granulosus caspase 3 0.0073 0.0701 0.0971
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.008 0.079 0.1094
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.0383 0.118
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0286 0.0443
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0532 0.0532
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0328 0.5659
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.002 0.0099 0.0332
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0016 0.0058 0.0068

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1879 nM Inhibition of [3H]-MK-801 binding to the PCP receptor site in guinea pig brain homogenate ChEMBL. 8101572
IC50 (binding) = 1879 nM Inhibition of [3H]-MK-801 binding to the PCP receptor site in guinea pig brain homogenate ChEMBL. 8101572

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

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