Detailed information for compound 932880

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 357.384 | Formula: C17H15N3O4S
  • H donors: 1 H acceptors: 6 LogP: 1.83 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)c1cccc(n1)S(=O)(=O)N1CCCC1C(=O)O
  • InChi: 1S/C17H15N3O4S/c18-11-12-6-8-13(9-7-12)14-3-1-5-16(19-14)25(23,24)20-10-2-4-15(20)17(21)22/h1,3,5-9,15H,2,4,10H2,(H,21,22)
  • InChiKey: MPFZYRPEJBNKBI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0067 0.0075
Brugia malayi hypothetical protein 0.0076 0.0908 0.1041
Echinococcus multilocularis aryl hydrocarbon receptor 0.0142 0.1895 0.1895
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0001 0.0001
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0031 0.0225 0.5
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0029 0.0199 0.0783
Leishmania major hypothetical protein, conserved 0.0029 0.0199 0.1145
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0132 0.1736 0.1736
Onchocerca volvulus Peroxidasin homolog 0.0055 0.0582 0.2973
Echinococcus multilocularis thyroid hormone receptor alpha 0.0043 0.0403 0.0403
Brugia malayi Animal haem peroxidase family protein 0.0055 0.0582 0.0668
Brugia malayi EGF-like domain containing protein 0.0018 0.003 0.0035
Schistosoma mansoni hypothetical protein 0.0132 0.1736 0.1736
Echinococcus multilocularis mitogen activated protein kinase 11 0.0131 0.1727 0.1727
Onchocerca volvulus Putative endochitinase 0.0093 0.1157 0.6068
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.0403 0.0403
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0067 0.0067
Brugia malayi tailless protein 0.002 0.0067 0.0077
Echinococcus granulosus fibropellin Ia 0.0018 0.003 0.003
Echinococcus granulosus intermediate filament protein 0.0027 0.0167 0.0167
Toxoplasma gondii microneme protein MIC17B 0.002 0.0067 0.0148
Trypanosoma cruzi heat shock protein 90, putative 0.0066 0.0759 0.4392
Brugia malayi notch-like transmembrane receptor 0.0018 0.003 0.0035
Schistosoma mansoni septate junction protein 0.0018 0.003 0.003
Onchocerca volvulus 0.0029 0.0199 0.0908
Brugia malayi EGF-like domain containing protein 0.0018 0.003 0.0035
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1248 0.1431
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0564 0.0564
Echinococcus granulosus calcium activated potassium channel variant 0.0042 0.0392 0.0392
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0018 0.0032 0.0032
Brugia malayi Hsp90 protein 0.0027 0.0174 0.0199
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Brugia malayi MAP kinase sur-1 0.0053 0.0564 0.0647
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.0403 0.0403
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0445 0.0511
Echinococcus granulosus lamin 0.0027 0.0167 0.0167
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0564 0.7352
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Schistosoma mansoni nuclear receptor 0.002 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.019
Loa Loa (eye worm) hypothetical protein 0.0043 0.0403 0.046
Loa Loa (eye worm) animal heme peroxidase 0.0055 0.0582 0.0666
Brugia malayi PAN domain containing protein 0.002 0.0067 0.0077
Brugia malayi nuclear hormone receptor 0.0043 0.0403 0.0462
Loa Loa (eye worm) hypothetical protein 0.0142 0.1886 0.2162
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0067 0.0067
Schistosoma mansoni patched 1 0.0042 0.0394 0.0394
Brugia malayi Serotonin receptor 0.0384 0.5514 0.6322
Schistosoma mansoni laminin gamma-3 chain 0.0018 0.003 0.003
Echinococcus multilocularis fibropellin Ia 0.0018 0.003 0.003
Echinococcus granulosus endoplasmin 0.0053 0.0557 0.0557
Echinococcus multilocularis neural cadherin 0.0018 0.003 0.003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0042 0.0238
Entamoeba histolytica hypothetical protein 0.0076 0.0908 0.7305
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0029 0.0199 0.0783
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0908 0.0908
Echinococcus multilocularis protein patched 0.0042 0.0394 0.0394
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0564 0.0564
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0025
Brugia malayi Nuclear hormone receptor E75 0.002 0.0067 0.0077
Brugia malayi Nuclear hormone receptor E75 0.002 0.0067 0.0077
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.0403 0.0403
Echinococcus granulosus Ankyrin 0.0016 0.0002 0.0002
Echinococcus granulosus neural cadherin 0.0018 0.003 0.003
Entamoeba histolytica heat shock protein 90, putative 0.0066 0.0759 0.605
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0167 0.019
Loa Loa (eye worm) hypothetical protein 0.0055 0.0582 0.0666
Schistosoma mansoni hypothetical protein 0.0018 0.003 0.003
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.0403 0.0462
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Echinococcus multilocularis GPCR, family 2 0.0031 0.0236 0.0236
Echinococcus multilocularis jun protein 0.0087 0.1069 0.1069
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.003 0.0035
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Brugia malayi beta-lactamase 0.0029 0.0199 0.0228
Loa Loa (eye worm) hypothetical protein 0.0055 0.0582 0.0666
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0067 0.0075
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0353 0.2036
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Mycobacterium ulcerans chitinase/cellulase 0.0071 0.0825 1
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0067 0.0067
Brugia malayi PAN domain containing protein 0.002 0.0067 0.0077
Loa Loa (eye worm) hypothetical protein 0.0057 0.0615 0.0704
Schistosoma mansoni hypothetical protein 0.0168 0.228 0.228
Entamoeba histolytica heat shock protein 90, putative 0.0066 0.0759 0.605
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.0403 0.0403
Mycobacterium ulcerans heat shock protein 90 0.0053 0.0557 0.658
Brugia malayi ecdysteroid receptor 0.0043 0.0403 0.0462
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0067 0.0197
Echinococcus multilocularis beta LACTamase domain containing family member 0.0029 0.0199 0.0199
Brugia malayi Animal haem peroxidase family protein 0.0055 0.0582 0.0668
Onchocerca volvulus 0.002 0.0067 0.0197
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.3393 0.3889
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0394 0.0394
Mycobacterium leprae conserved hypothetical protein 0.0029 0.0199 0.3294
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0103 0.0103
Toxoplasma gondii PAN domain-containing protein 0.002 0.0067 0.0148
Brugia malayi Delta serrate ligand family protein 0.0018 0.003 0.0035
Onchocerca volvulus 0.0132 0.1736 0.9189
Schistosoma mansoni hypothetical protein 0.0018 0.003 0.003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.0403 0.046
Echinococcus multilocularis microtubule associated protein 2 0.0685 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0582 0.0666
Brugia malayi PAN domain containing protein 0.002 0.0067 0.0077
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0564 0.3262
Brugia malayi EGF-like domain containing protein 0.0018 0.003 0.0035
Mycobacterium tuberculosis Probable lipase LipD 0.0029 0.0199 0.0783
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0043 0.0403 0.046
Schistosoma mansoni hypothetical protein 0.0018 0.003 0.003
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0002 0.0002
Mycobacterium ulcerans chitinase/cellulase 0.0071 0.0825 1
Schistosoma mansoni notch 0.0018 0.003 0.003
Echinococcus granulosus calcium activated potassium channel 0.0046 0.0453 0.0453
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0199 0.239
Echinococcus multilocularis endoplasmin 0.0053 0.0557 0.0557
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0564 0.7352
Toxoplasma gondii 1,3(4)-beta-glucanase 0.002 0.0067 0.0148
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0042 0.0049
Leishmania major heat shock protein 83-1 0.0066 0.0759 0.4392
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0403 0.0462
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0027 0.0174 0.1107
Schistosoma mansoni zinc finger protein 0.0016 0.0002 0.0002
Mycobacterium tuberculosis Conserved protein 0.0029 0.0199 0.0783
Echinococcus granulosus fetal alzheimer antigen falz 0.0018 0.0038 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.0403 0.046
Brugia malayi PAN domain containing protein 0.002 0.0067 0.0077
Toxoplasma gondii PAN/Apple domain-containing protein 0.002 0.0067 0.0148
Brugia malayi Endoplasmin precursor 0.0066 0.0759 0.087
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0564 0.3262
Onchocerca volvulus Peroxidasin homolog 0.0055 0.0582 0.2973
Loa Loa (eye worm) animal heme peroxidase 0.0055 0.0582 0.0666
Schistosoma mansoni notch 0.0018 0.003 0.003
Trypanosoma brucei Heat shock protein 83, putative 0.0066 0.0759 0.4392
Loa Loa (eye worm) hypothetical protein 0.0031 0.0236 0.0269
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0027 0.0174 0.0174
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0564 0.3262
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0199 0.1139
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0067 0.0067
Mycobacterium ulcerans beta-lactamase 0.0029 0.0199 0.2001
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Echinococcus granulosus neuropeptide s receptor 0.0471 0.6804 0.6804
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0029 0.0198 0.0198
Leishmania major heat shock protein 83-1 0.0066 0.0759 0.4392
Loa Loa (eye worm) hypothetical protein 0.0071 0.0825 0.0944
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0053 0.0557 0.0557
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.0199 0.239
Onchocerca volvulus 0.002 0.0067 0.0197
Schistosoma mansoni hypothetical protein 0.0168 0.228 0.228
Trypanosoma brucei heat shock protein, putative 0.0066 0.0759 0.4392
Brugia malayi GCC2 and GCC3 family protein 0.0018 0.003 0.0035
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0042 0.0237
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0394 0.045
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0174 0.0993
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0174 0.2044
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0018 0.003 0.003
Leishmania major heat shock protein 83-1 0.0066 0.0759 0.4392
Echinococcus multilocularis potassium large conductance calcium activated 0.0045 0.0439 0.0439
Onchocerca volvulus 0.002 0.0067 0.0197
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0127 0.1664 0.1664
Echinococcus granulosus hypothetical protein 0.057 0.8281 0.8281
Mycobacterium tuberculosis Conserved protein 0.0029 0.0199 0.0783
Leishmania major heat shock protein 83-1 0.0066 0.0759 0.4392
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0067 0.0197
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0067 0.0075
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0029 0.0199 0.0227
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0042 0.0238
Loa Loa (eye worm) hypothetical protein 0.0026 0.016 0.0182
Echinococcus granulosus protein jagged 2 0.0018 0.003 0.003
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.0403 0.0403
Brugia malayi Blistered cuticle protein 3 0.0055 0.0582 0.0668
Schistosoma mansoni coup transcription factor 0.0043 0.0403 0.0403
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0055 0.0582 0.0666
Echinococcus multilocularis neurogenic locus protein delta 0.0018 0.003 0.003
Brugia malayi hypothetical protein 0.0055 0.0582 0.0668
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0031 0.0227 0.0259
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0042 0.0392 0.0448
Onchocerca volvulus 0.0043 0.0403 0.2007
Toxoplasma gondii hypothetical protein 0.002 0.0067 0.0148
Loa Loa (eye worm) hypothetical protein 0.0029 0.0199 0.0227
Brugia malayi heat shock protein 90 0.0066 0.0759 0.087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0445 0.0445
Schistosoma mansoni lamin 0.0027 0.0167 0.0167
Echinococcus granulosus neuropeptide receptor A26 0.0471 0.6804 0.6804
Loa Loa (eye worm) hypothetical protein 0.003 0.0213 0.0243
Brugia malayi nuclear receptor RXR 0.0022 0.0103 0.0118
Echinococcus multilocularis neurogenic locus notch protein 0.0018 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0018 0.003 0.003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0403 0.046
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Toxoplasma gondii Hsp90 domain-containing protein 0.0027 0.0174 0.0389
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0042 0.0238
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0199 0.1145
Leishmania major heat shock protein 83-1 0.0066 0.0759 0.4392
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0564 0.3262
Echinococcus granulosus mitogen activated protein kinase 14 0.0131 0.1727 0.1727
Mycobacterium ulcerans esterase/lipase LipP 0.0029 0.0199 0.2001
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0027 0.0174 0.0174
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0067 0.0075
Schistosoma mansoni hypothetical protein 0.004 0.0371 0.0371
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.0403 0.0462
Schistosoma mansoni heat shock protein 0.0066 0.0759 0.0759
Echinococcus multilocularis tumor protein p63 0.0366 0.5241 0.5241
Toxoplasma gondii microneme protein MIC4 0.002 0.0067 0.0148
Onchocerca volvulus Huntingtin homolog 0.0122 0.1584 0.8369
Brugia malayi endochitinase 0.0083 0.1007 0.1155
Plasmodium vivax endoplasmin, putative 0.0066 0.0759 0.4369
Echinococcus granulosus mitogen activated protein kinase 11 0.0131 0.1727 0.1727
Loa Loa (eye worm) notch protein 0.0018 0.003 0.0033
Plasmodium vivax heat shock protein 90, putative 0.0027 0.0174 0.0993
Loa Loa (eye worm) Notch2 0.0018 0.003 0.0033
Brugia malayi ecdysone receptor 0.002 0.0067 0.0077
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.0403 0.0403
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0131 0.1727 0.1978
Loa Loa (eye worm) DR-78 0.002 0.0067 0.0075
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0132 0.1736 0.1736
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0042 0.0263
Brugia malayi hypothetical protein 0.0022 0.0103 0.0118
Loa Loa (eye worm) MaxiK calcium-activated potassium channel 0.003 0.0213 0.0243
Trypanosoma cruzi heat shock protein 90, putative 0.0053 0.0557 0.3221
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.0403 0.0462
Schistosoma mansoni heat shock protein 0.0027 0.0174 0.0174
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0067 0.0075
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1248 0.1431
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0018 0.0037 0.0209
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0403 0.0403
Onchocerca volvulus Putative endochitinase 0.0083 0.1007 0.5263
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0116
Echinococcus granulosus tumor protein p63 0.0366 0.5241 0.5241
Leishmania major heat shock protein, putative 0.0027 0.0174 0.0998
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0167 0.019
Onchocerca volvulus 0.0029 0.0199 0.0908
Echinococcus granulosus heat shock protein 90 0.0053 0.0557 0.0557
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0236 0.0269
Onchocerca volvulus 0.002 0.0067 0.0197
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0199 0.0199
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.0403 0.046
Echinococcus granulosus protein jagged 1 0.0018 0.003 0.003
Brugia malayi Animal haem peroxidase family protein 0.0055 0.0582 0.0668
Brugia malayi CHE-14 protein 0.0042 0.0394 0.0451
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0403 0.0462
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0564 0.7325
Giardia lamblia Heat shock protein HSP 90-alpha 0.0053 0.0557 0.7227
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0067 0.0077
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0018 0.0032 0.0035
Echinococcus granulosus peroxidasin 0.0055 0.0582 0.0582
Echinococcus granulosus slit 2 protein 0.0018 0.003 0.003
Toxoplasma gondii ABC1 family protein 0.0029 0.0199 0.0447
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0018 0.003 0.000000072763
Schistosoma mansoni retinoic acid receptor RXR 0.0149 0.2 0.2
Onchocerca volvulus 0.002 0.0067 0.0197
Toxoplasma gondii PAN domain-containing protein 0.0312 0.4427 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0582 0.0666
Echinococcus granulosus FTZ F1 alpha 0.0043 0.0403 0.0403
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0564 0.3262
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.0403 0.2007
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0908 0.0908
Brugia malayi Endochitinase 0.0093 0.1157 0.1326
Brugia malayi EGF-like domain containing protein 0.0018 0.003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Trichomonas vaginalis heat shock protein, putative 0.0053 0.0557 0.7255
Mycobacterium leprae Probable lipase LipE 0.0029 0.0199 0.3294
Loa Loa (eye worm) heat shock protein 75 0.0027 0.0174 0.0197
Brugia malayi Bromodomain containing protein 0.006 0.0667 0.0764
Plasmodium falciparum endoplasmin, putative 0.0041 0.0376 0.2158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.0403 0.046
Leishmania major chitinase 0.0083 0.1007 0.583
Schistosoma mansoni hypothetical protein 0.004 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0132 0.1736 0.1989
Trypanosoma brucei protein kinase, putative 0.0053 0.0564 0.3262
Mycobacterium tuberculosis Possible chitinase 0.0071 0.0825 0.326
Echinococcus granulosus heat shock protein 0.0066 0.0759 0.0759
Treponema pallidum heat shock protein 90 0.0053 0.0557 1
Plasmodium falciparum conserved protein, unknown function 0.0132 0.1736 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0067 0.0067
Toxoplasma gondii hypothetical protein 0.002 0.0067 0.0148
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Echinococcus granulosus zinc finger protein 0.0016 0.0002 0.0002
Toxoplasma gondii heat shock protein HSP90 0.0066 0.0759 0.1712
Loa Loa (eye worm) hypothetical protein 0.0125 0.163 0.1868
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0067 0.0067
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0564 0.3262
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0029 0.0199 0.2001
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0103 0.0116
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0042 0.0237
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1537 0.1761
Brugia malayi Bromodomain containing protein 0.0031 0.0227 0.026
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.0403 0.0462
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Trypanosoma cruzi Heat shock protein 83, putative 0.0066 0.0759 0.4392
Loa Loa (eye worm) hypothetical protein 0.0068 0.0779 0.0892
Brugia malayi Peroxidasin 0.0055 0.0582 0.0668
Mycobacterium ulcerans putative regulatory protein 0.0049 0.0496 0.5802
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0042 0.0047
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0564 0.3262
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0564 0.7352
Onchocerca volvulus 0.0027 0.0167 0.0736
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0033 0.0256 0.0292
Leishmania major heat shock protein 83-1 0.0066 0.0759 0.4392
Echinococcus granulosus potassium large conductance calcium activated 0.0045 0.0439 0.0439
Brugia malayi endochitinase 0.0093 0.1157 0.1326
Brugia malayi P38 map kinase family protein 2 0.0131 0.1727 0.198
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.1227 0.1407
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0067 0.0067
Brugia malayi PAN domain containing protein 0.002 0.0067 0.0077
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0599 0.8722 1
Schistosoma mansoni hypothetical protein 0.0071 0.0825 0.0825
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0067 0.0075
Brugia malayi MH2 domain containing protein 0.0118 0.1537 0.1763
Echinococcus granulosus nuclear factor of activated T cells 5 0.008 0.096 0.096
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0103 0.0118
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0053 0.0557 0.2201
Onchocerca volvulus 0.0054 0.0568 0.2898
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0445 0.0445
Schistosoma mansoni intermediate filament proteins 0.0027 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0043 0.0403 0.046
Schistosoma mansoni calcium-activated potassium channel 0.0042 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0043 0.0403 0.046
Brugia malayi Cadherin domain containing protein 0.0018 0.003 0.0035
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1248 0.143
Schistosoma mansoni calcium-activated potassium channel 0.0045 0.0439 0.0439
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0043 0.0403 0.046
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Loa Loa (eye worm) hypothetical protein 0.0043 0.0403 0.046
Loa Loa (eye worm) endoplasmin 0.0066 0.0759 0.0869
Schistosoma mansoni notch 0.0018 0.003 0.003
Echinococcus granulosus delta-like protein 1 0.0018 0.003 0.003
Entamoeba histolytica hypothetical protein 0.0076 0.0908 0.7305
Echinococcus multilocularis heat shock protein 90 0.0066 0.0759 0.0759
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0042 0.0238
Trypanosoma brucei heat shock protein 90, putative 0.0066 0.0759 0.4392
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0053 0.0557 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0018 0.0038 0.0038
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0403 0.0403
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0103 0.0118
Brugia malayi follicle stimulating hormone receptor 0.0243 0.3393 0.389
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0067 0.0067
Trypanosoma brucei heat shock protein 90, putative 0.0066 0.0759 0.4392
Onchocerca volvulus 0.0029 0.0199 0.0908
Brugia malayi intermediate filament protein 0.0027 0.0167 0.0191
Onchocerca volvulus Chorion peroxidase homolog 0.0055 0.0582 0.2973
Leishmania major heat shock protein 83-1 0.0066 0.0759 0.4392
Echinococcus multilocularis geminin 0.0168 0.228 0.228
Trichomonas vaginalis endoplasmin, putative 0.0041 0.0376 0.4789
Schistosoma mansoni neuropeptide receptor 0.0166 0.2256 0.2256
Plasmodium vivax hypothetical protein, conserved 0.0132 0.1736 1
Loa Loa (eye worm) microfilarial chitinase 0.0081 0.0974 0.1115
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0018 0.0037 0.0209
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Loa Loa (eye worm) hypothetical protein 0.0099 0.1248 0.143
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.003 0.0035
Trypanosoma brucei heat shock protein, putative 0.0066 0.0759 0.4392
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0403 0.0462
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.0403 0.0403
Schistosoma mansoni slit 0.0018 0.003 0.003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0087 0.1069 0.1069
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0564 0.1272
Toxoplasma gondii microneme protein MIC17C 0.002 0.0067 0.0148
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0779 0.0894
Brugia malayi Animal haem peroxidase family protein 0.0055 0.0582 0.0668
Schistosoma mansoni hypothetical protein 0.0068 0.0779 0.0779
Loa Loa (eye worm) hypothetical protein 0.0098 0.1227 0.1405
Echinococcus multilocularis G protein coupled receptor 139 0.0166 0.2256 0.2256
Onchocerca volvulus 0.0055 0.0582 0.2973
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0042 0.0165
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0174 0.0993
Loa Loa (eye worm) hypothetical protein 0.0029 0.0199 0.0227
Loa Loa (eye worm) PHD-finger family protein 0.0017 0.0015 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0403 0.0403
Giardia lamblia Heat shock protein HSP 90-alpha 0.0066 0.0759 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.0403 0.0403
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0042 0.0042
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0564 0.0564
Onchocerca volvulus 0.002 0.0067 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.0403 0.0462
Brugia malayi Cadherin domain containing protein 0.0018 0.003 0.0035
Brugia malayi PAN domain containing protein 0.002 0.0067 0.0077
Schistosoma mansoni nuclear hormone receptor 0.002 0.0067 0.0067
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0067 0.0075
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0403 0.0462
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0394 0.5034
Entamoeba histolytica chitinase, putative 0.0083 0.1007 0.8144
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0236 0.0236
Loa Loa (eye worm) beta-lactamase 0.0029 0.0199 0.0227
Echinococcus granulosus protein jagged 2 0.0018 0.003 0.003
Schistosoma mansoni jun-related protein 0.0071 0.0825 0.0825
Schistosoma mansoni hypothetical protein 0.0031 0.0236 0.0236
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0027 0.0174 0.0771
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0029 0.0199 0.0228
Onchocerca volvulus 0.002 0.0067 0.0197
Brugia malayi PHD-finger family protein 0.002 0.0066 0.0076
Schistosoma mansoni hypothetical protein 0.0018 0.003 0.003
Echinococcus multilocularis notch 0.0018 0.003 0.003
Trypanosoma cruzi heat shock protein 85, putative 0.0066 0.0759 0.4392
Onchocerca volvulus 0.002 0.0067 0.0197
Brugia malayi EGF-like domain containing protein 0.0018 0.003 0.0035
Echinococcus multilocularis neuropeptide receptor 0.0166 0.2256 0.2256
Brugia malayi PAS domain containing protein 0.0066 0.0752 0.0862
Plasmodium vivax heat shock protein, putative 0.0027 0.0174 0.0993
Schistosoma mansoni nuclear receptor 0.002 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0034 0.0279 0.0318
Onchocerca volvulus 0.0027 0.0167 0.0736
Leishmania major heat shock protein 83-1 0.0066 0.0759 0.4392
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0116
Echinococcus granulosus heat shock protein 90 0.0066 0.0759 0.0759
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Schistosoma mansoni peroxidasin 0.0055 0.0582 0.0582
Echinococcus multilocularis protein jagged 2 0.0018 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0055 0.0582 0.0666
Schistosoma mansoni bromodomain containing protein 0.0051 0.0526 0.0526
Onchocerca volvulus 0.0142 0.1886 1
Brugia malayi Protein kinase domain containing protein 0.0017 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0122 0.1584 0.1815
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0564 0.0645
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.003 0.0213 0.0244
Schistosoma mansoni hypothetical protein 0.0031 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0001 0.0001
Echinococcus multilocularis slit 2 protein 0.0018 0.003 0.003
Loa Loa (eye worm) animal heme peroxidase 0.0055 0.0582 0.0666
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0053 0.0557 0.3221
Onchocerca volvulus 0.0055 0.0582 0.2973
Echinococcus granulosus lamin dm0 0.0027 0.0167 0.0167
Giardia lamblia Grp94/Hsp90 0.0053 0.0557 0.7227
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.0403 0.0403
Echinococcus multilocularis neuropeptide s receptor 0.0471 0.6804 0.6804
Echinococcus multilocularis protein jagged 1 0.0018 0.003 0.003
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0042 0.0163
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0067 0.0077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0199 0.0199
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.125 0.125
Onchocerca volvulus 0.0055 0.0582 0.2973
Onchocerca volvulus 0.002 0.0067 0.0197
Entamoeba histolytica hypothetical protein 0.0076 0.0908 0.7305
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0087 0.1069 0.1069
Brugia malayi PAN domain containing protein 0.002 0.0067 0.0077
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0067 0.0067
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1537 0.1761
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0445 0.0509
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.0403 0.046
Brugia malayi Animal haem peroxidase family protein 0.0055 0.0582 0.0668
Loa Loa (eye worm) animal heme peroxidase 0.0055 0.0582 0.0666
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.1854 0.1854
Echinococcus granulosus aryl hydrocarbon receptor 0.0142 0.1895 0.1895
Mycobacterium ulcerans hypothetical protein 0.0029 0.0199 0.2001
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0564 0.0564
Trypanosoma brucei heat shock protein, putative 0.0066 0.0759 0.4392
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Loa Loa (eye worm) hypothetical protein 0.0055 0.0582 0.0666
Onchocerca volvulus 0.0049 0.0505 0.2555
Echinococcus granulosus expressed conserved protein 0.0092 0.1138 0.1138
Onchocerca volvulus Putative endochitinase 0.0093 0.1157 0.6068
Echinococcus granulosus geminin 0.0168 0.228 0.228
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0067 0.0077
Onchocerca volvulus Neurogenic locus notch homolog 0.0018 0.0032 0.0011
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.0403 0.0462
Trypanosoma brucei heat shock protein, putative 0.0066 0.0759 0.4392
Loa Loa (eye worm) hypothetical protein 0.0055 0.0582 0.0666
Brugia malayi PAN domain containing protein 0.002 0.0067 0.0077
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0445 0.0445
Schistosoma mansoni heat shock protein 0.0066 0.0759 0.0759
Echinococcus multilocularis protein jagged 1 0.0018 0.003 0.003
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0199 0.1145
Schistosoma mansoni hypothetical protein 0.0031 0.0236 0.0236
Echinococcus multilocularis neurogenic locus notch protein 4 0.0018 0.003 0.003
Leishmania major heat shock protein 83-1 0.0066 0.0759 0.4392
Echinococcus multilocularis mitogen activated protein kinase 14 0.0131 0.1727 0.1727
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.0403 0.0403
Toxoplasma gondii subtilisin SUB12 0.002 0.0067 0.0148
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Loa Loa (eye worm) hypothetical protein 0.0055 0.0582 0.0666
Mycobacterium tuberculosis Probable lipase LipE 0.0029 0.0199 0.0783
Echinococcus granulosus single minded 2 0.0049 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Echinococcus granulosus neurogenic locus notch protein 0.0018 0.003 0.003
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0131 0.1727 1
Toxoplasma gondii PAN domain-containing protein 0.002 0.0067 0.0148
Echinococcus multilocularis mitogen activated protein kinase 11 0.0131 0.1727 0.1727
Onchocerca volvulus 0.0068 0.0789 0.4089
Trypanosoma brucei heat shock protein, putative 0.0066 0.0759 0.4392
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0067 0.0067
Brugia malayi hypothetical protein 0.002 0.0067 0.0077
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0018 0.0037 0.0209
Echinococcus granulosus neuropeptide receptor 0.0166 0.2256 0.2256
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0067 0.0067
Brugia malayi hypothetical protein 0.0022 0.0103 0.0118
Loa Loa (eye worm) hypothetical protein 0.0122 0.1584 0.1815
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0116
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.0023 0.0126
Echinococcus multilocularis protein dispatched 1 0.0048 0.0482 0.0482
Onchocerca volvulus 0.002 0.0067 0.0197
Loa Loa (eye worm) hypothetical protein 0.0125 0.1639 0.1878
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.1854 0.1854
Echinococcus multilocularis heat shock protein 0.0066 0.0759 0.0759
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Trypanosoma brucei heat shock protein 84, putative 0.0027 0.0174 0.0998
Schistosoma mansoni hypothetical protein 0.004 0.0371 0.0371
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.0199 0.239
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Toxoplasma gondii microneme protein MIC17A 0.002 0.0067 0.0148
Loa Loa (eye worm) hypothetical protein 0.0043 0.0403 0.046
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.0023 0.0126
Brugia malayi small heat shock protein 0.0599 0.8722 1
Brugia malayi nuclear hormone receptor 0.002 0.0067 0.0077
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0048 0.0483 0.0483
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0564 0.0564
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0131 0.1727 1
Schistosoma mansoni cell polarity protein 0.0018 0.003 0.003
Schistosoma mansoni lamin 0.0027 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0564 0.7352
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0131 0.1727 1
Mycobacterium tuberculosis Probable hydrolase 0.0029 0.0199 0.0783
Toxoplasma gondii PAN domain-containing protein 0.002 0.0067 0.0148
Echinococcus multilocularis calcium activated potassium channel 0.0046 0.0453 0.0453
Toxoplasma gondii hypothetical protein 0.0132 0.1736 0.3919
Loa Loa (eye worm) hypothetical protein 0.0055 0.0582 0.0666
Onchocerca volvulus Putative endochitinase 0.0093 0.1157 0.6068
Echinococcus multilocularis transfer RNA-Lys 0.0049 0.0496 0.0496
Trypanosoma cruzi heat shock protein 85, putative 0.0066 0.0759 0.4392
Leishmania major heat shock protein 83-1 0.0066 0.0759 0.4392
Trypanosoma brucei heat shock protein, putative 0.0066 0.0759 0.4392
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.0403 0.2007
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.1227 0.1227
Toxoplasma gondii microneme protein, putative 0.002 0.0067 0.0148
Leishmania major heat shock protein 83-1 0.0066 0.0759 0.4392
Brugia malayi conserved hypotetical protein 0.002 0.0067 0.0077
Brugia malayi nuclear receptor NHR-67 0.002 0.0067 0.0077
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.0403 0.0403
Echinococcus multilocularis lamin 0.0027 0.0167 0.0167
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0445 0.0445
Schistosoma mansoni endoplasmin 0.0066 0.0759 0.0759
Schistosoma mansoni notch 0.0018 0.003 0.003
Onchocerca volvulus Peroxidase homolog 0.0055 0.0582 0.2973
Schistosoma mansoni hypothetical protein 0.0076 0.0908 0.0908
Toxoplasma gondii heat shock protein 75, putative 0.0027 0.0174 0.0389
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0199 0.1145
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0236 0.027
Echinococcus multilocularis zinc finger protein 0.0016 0.0002 0.0002
Echinococcus multilocularis Ankyrin 0.0016 0.0002 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0445 0.0445
Onchocerca volvulus Putative endochitinase 0.0083 0.1007 0.5263
Brugia malayi PAN domain containing protein 0.002 0.0067 0.0077
Toxoplasma gondii PAN domain-containing protein 0.002 0.0067 0.0148
Loa Loa (eye worm) hypothetical protein 0.0055 0.0582 0.0666
Echinococcus multilocularis peroxidasin 0.0055 0.0582 0.0582
Echinococcus multilocularis neurogenic locus protein delta 0.0018 0.003 0.003
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.1227 1
Mycobacterium tuberculosis Conserved protein 0.0029 0.0199 0.0783
Brugia malayi hypothetical protein 0.0122 0.1584 0.1816
Loa Loa (eye worm) hypothetical protein 0.0055 0.0582 0.0666
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.003 0.0035
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0048 0.0483 0.0483
Leishmania major heat shock protein 83-1 0.0066 0.0759 0.4392
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0445 0.0445
Schistosoma mansoni microtubule-associated protein tau 0.0685 1 1
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0067 0.0067
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0236 0.0236
Schistosoma mansoni single-minded 0.0066 0.0752 0.0752
Onchocerca volvulus 0.002 0.0067 0.0197
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0125 0.163 0.1869
Trichomonas vaginalis heat shock protein, putative 0.0066 0.0759 1
Toxoplasma gondii exonuclease III APE 0.0018 0.0042 0.0093
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0029 0.0198 0.0198
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0403 0.0403
Loa Loa (eye worm) heat shock protein 90 0.0066 0.0759 0.0869
Trypanosoma cruzi heat shock protein 85, putative 0.0053 0.0557 0.3221
Echinococcus multilocularis musashi 0.0027 0.0167 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.0403 0.046
Brugia malayi nuclear receptor NHR-88 0.0043 0.0403 0.0462
Trichomonas vaginalis heat shock protein, putative 0.0053 0.0557 0.7255
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.0403 0.046
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Mycobacterium ulcerans lipase LipD 0.0029 0.0199 0.2001
Schistosoma mansoni nuclear hormone receptor 0.002 0.0067 0.0067
Brugia malayi bZIP transcription factor family protein 0.0087 0.1069 0.1226
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0403 0.0462
Toxoplasma gondii PAN domain-containing protein 0.0312 0.4427 1
Brugia malayi nuclear receptor NHR-88 0.002 0.0067 0.0077
Leishmania major heat shock protein 83-1 0.0066 0.0759 0.4392
Schistosoma mansoni endoplasmin 0.0066 0.0759 0.0759
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.0403 0.0403
Echinococcus multilocularis fat cadherin tumor suppressor 0.0018 0.003 0.003
Trichomonas vaginalis heat shock protein, putative 0.0041 0.0376 0.4789
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Trypanosoma cruzi heat shock protein 85, putative 0.0066 0.0759 0.4392
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0103 0.0103
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0185 0.2526 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0568 0.065
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Mycobacterium tuberculosis Probable esterase LipL 0.0029 0.0199 0.0783
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.0403 0.0462
Plasmodium falciparum heat shock protein 90 0.0066 0.0759 0.4369
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0167 0.0191
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0445 0.0445
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.0403 0.0403
Brugia malayi hypothetical protein 0.0068 0.0789 0.0905
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0018 0.0032 0.0032
Plasmodium vivax heat shock protein 86, putative 0.0066 0.0759 0.4369
Leishmania major heat shock protein 83-1 0.0066 0.0759 0.4392
Leishmania major heat shock protein 83-1 0.0066 0.0759 0.4392
Brugia malayi EGF-like domain containing protein 0.0018 0.003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.0403 0.0462
Brugia malayi hypothetical protein 0.002 0.0067 0.0077
Echinococcus multilocularis neuropeptide receptor A26 0.0471 0.6804 0.6804
Echinococcus multilocularis neurogenic locus notch protein 0.0018 0.003 0.003
Brugia malayi beta-lactamase family protein 0.0029 0.0199 0.0228
Echinococcus multilocularis expressed conserved protein 0.0092 0.1138 0.1138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.0403 0.046
Trichomonas vaginalis esterase, putative 0.0029 0.0199 0.239
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0067 0.0077
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0018 0.0038 0.0038
Schistosoma mansoni aryl hydrocarbon receptor 0.0191 0.2624 0.2624
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0568 0.0568
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.0403 0.0403
Onchocerca volvulus Dual oxidase homolog 0.0055 0.0582 0.2973
Schistosoma mansoni hypothetical protein 0.0031 0.0236 0.0236
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0149 0.2 0.2
Echinococcus granulosus neurogenic locus notch protein 4 0.0018 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0132 0.1736 0.1989
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0053 0.0557 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0055 0.0582 0.0666
Loa Loa (eye worm) hypothetical protein 0.0051 0.0535 0.0611
Echinococcus granulosus beta LACTamase domain containing family member 0.0029 0.0199 0.0199
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0908 0.0908
Trypanosoma brucei heat shock protein, putative 0.0066 0.0759 0.4392
Echinococcus granulosus neurogenic locus notch protein 0.0018 0.003 0.003
Trypanosoma cruzi heat shock protein, putative 0.0027 0.0174 0.0998
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0001 0.0001
Leishmania major protein kinase, putative 0.0018 0.0037 0.0209
Entamoeba histolytica hypothetical protein 0.0076 0.0908 0.7305
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0403 0.0462
Echinococcus granulosus notch 0.0018 0.003 0.003
Echinococcus granulosus GPCR family 2 0.0031 0.0236 0.0236
Leishmania major heat shock protein 83-1 0.0066 0.0759 0.4392
Loa Loa (eye worm) hypothetical protein 0.0085 0.1033 0.1183
Echinococcus multilocularis nuclear factor of activated T cells 5 0.008 0.096 0.096
Schistosoma mansoni peroxidasin 0.0055 0.0582 0.0582
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0132 0.1736 0.199
Onchocerca volvulus 0.002 0.0067 0.0197
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.1227 0.1227
Trichomonas vaginalis heat shock protein, putative 0.0053 0.0557 0.7255
Brugia malayi isocitrate dehydrogenase 0.0016 0.0001 0.0002
Brugia malayi nuclear receptor RXR 0.002 0.0067 0.0077
Echinococcus multilocularis mitogen activated protein kinase 14 0.0131 0.1727 0.1727
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0018 0.0037 0.0209
Loa Loa (eye worm) hypothetical protein 0.0042 0.0394 0.045
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Brugia malayi bHLH-PAS transcription factor 0.0049 0.0496 0.0569
Schistosoma mansoni zinc finger protein 0.002 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0018 0.003 0.003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0236 0.0236
Loa Loa (eye worm) cuticular endochitinase 0.0083 0.1007 0.1153
Brugia malayi EGF-like domain containing protein 0.0018 0.003 0.0035
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0067 0.0075
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0042 0.0263
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0067 0.0067
Echinococcus granulosus neurogenic locus protein delta 0.0018 0.003 0.003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0055 0.0582 0.0666
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0116
Schistosoma mansoni hypothetical protein 0.0018 0.003 0.003
Echinococcus multilocularis heat shock protein 90 0.0053 0.0557 0.0557
Echinococcus multilocularis lamin dm0 0.0027 0.0167 0.0167
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0055 0.0582 0.0666
Echinococcus granulosus protein jagged 1 0.0018 0.003 0.003
Loa Loa (eye worm) chitinase I 0.0083 0.1007 0.1153
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.0403 0.0462
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0029 0.0199 0.0783
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0067 0.0067
Onchocerca volvulus 0.0132 0.1736 0.9189
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Schistosoma mansoni hypothetical protein 0.004 0.0371 0.0371
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0403 0.0462
Onchocerca volvulus Huntingtin homolog 0.0122 0.1584 0.8369
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0236 0.027
Toxoplasma gondii heat shock protein 90, putative 0.0066 0.0759 0.1712
Schistosoma mansoni ap endonuclease 0.0018 0.0042 0.0042
Brugia malayi beta-lactamase family protein 0.0029 0.0199 0.0228
Echinococcus multilocularis calcium activated potassium channel variant 0.0042 0.0392 0.0392
Schistosoma mansoni hypothetical protein 0.0017 0.0015 0.0015
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0029 0.0199 0.0227
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Loa Loa (eye worm) hypothetical protein 0.0029 0.0199 0.0227
Brugia malayi PAN domain containing protein 0.002 0.0067 0.0077
Brugia malayi Muscle positioning protein 4 0.0018 0.003 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0199 0.239
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0001
Leishmania major heat shock protein 83-1 0.0066 0.0759 0.4392
Onchocerca volvulus Peroxidase homolog 0.0055 0.0582 0.2973
Brugia malayi hypothetical protein 0.0017 0.0023 0.0026
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0199 0.239
Schistosoma mansoni ap endonuclease 0.0018 0.0042 0.0042
Toxoplasma gondii EGF family domain-containing protein 0.0018 0.003 0.0066
Trypanosoma brucei heat shock protein, putative 0.0066 0.0759 0.4392
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0131 0.1727 1
Echinococcus multilocularis conserved hypothetical protein 0.0555 0.8066 0.8066
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0018 0.003 0.0035
Echinococcus granulosus jun protein 0.0087 0.1069 0.1069
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.0403 0.0403
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.0403 0.2007
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0033
Onchocerca volvulus 0.002 0.0067 0.0197
Schistosoma mansoni notch 0.0018 0.003 0.003
Schistosoma mansoni notch 0.0018 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0029 0.0199 0.0227
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0075
Brugia malayi steroid hormone receptor 0.0043 0.0403 0.0462
Leishmania major protein kinase, putative 0.0018 0.0037 0.0209
Loa Loa (eye worm) hypothetical protein 0.0029 0.0199 0.0227
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.0023 0.0126

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 21000 nM Inhibition of human 11-betaHSD1 by biochemical assay ChEMBL. 25266782

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.