Detailed information for compound 938693

Basic information

Technical information
  • TDR Targets ID: 938693
  • Name: 3-[(3R,4R)-3,4-dimethyl-1-[[(1S,2S)-2-phenylc yclopropyl]methyl]piperidin-4-yl]phenol
  • MW: 335.482 | Formula: C23H29NO
  • H donors: 1 H acceptors: 1 LogP: 5.26 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cccc(c1)[C@]1(C)CCN(C[C@@H]1C)C[C@H]1C[C@@H]1c1ccccc1
  • InChi: 1S/C23H29NO/c1-17-15-24(16-19-13-22(19)18-7-4-3-5-8-18)12-11-23(17,2)20-9-6-10-21(25)14-20/h3-10,14,17,19,22,25H,11-13,15-16H2,1-2H3/t17-,19+,22+,23+/m0/s1
  • InChiKey: ZBKMHZDNQWQSNM-FEWCVYDTSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(3R,4R)-3,4-dimethyl-1-[[(1S,2S)-2-phenylcyclopropyl]methyl]-4-piperidyl]phenol
  • 3-[(3R,4R)-3,4-dimethyl-1-[[(1S,2S)-2-phenylcyclopropyl]methyl]-4-piperidinyl]phenol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Kappa opioid receptor Starlite/ChEMBL References
Rattus norvegicus Delta opioid receptor Starlite/ChEMBL References
Rattus norvegicus Mu opioid receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Delta opioid receptor   372 aa 316 aa 26.9 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Delta opioid receptor   372 aa 330 aa 24.2 %
Schistosoma mansoni rhodopsin-like orphan GPCR Kappa opioid receptor   380 aa 379 aa 22.4 %
Onchocerca volvulus Kappa opioid receptor   380 aa 310 aa 24.2 %
Schistosoma japonicum Rhodopsin, putative Mu opioid receptor   398 aa 328 aa 23.2 %
Echinococcus granulosus allatostatin A receptor Delta opioid receptor   372 aa 302 aa 27.8 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Delta opioid receptor   372 aa 315 aa 28.6 %
Onchocerca volvulus Phospholipase d-related homolog Kappa opioid receptor   380 aa 326 aa 20.9 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Delta opioid receptor   372 aa 320 aa 25.6 %
Loa Loa (eye worm) neuropeptide F receptor Delta opioid receptor   372 aa 317 aa 23.3 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Kappa opioid receptor   380 aa 352 aa 20.2 %
Onchocerca volvulus Delta opioid receptor   372 aa 386 aa 22.8 %
Brugia malayi hypothetical protein Kappa opioid receptor   380 aa 319 aa 21.6 %
Echinococcus granulosus somatostatin receptor Kappa opioid receptor   380 aa 342 aa 19.6 %
Onchocerca volvulus Delta opioid receptor   372 aa 344 aa 22.1 %
Onchocerca volvulus Mitogen-activated protein kinase kinase kinase 8 homolog Kappa opioid receptor   380 aa 395 aa 20.3 %
Echinococcus multilocularis growth hormone secretagogue receptor type 1 Kappa opioid receptor   380 aa 306 aa 21.2 %
Onchocerca volvulus Delta opioid receptor   372 aa 349 aa 22.1 %
Brugia malayi hypothetical protein Kappa opioid receptor   380 aa 320 aa 20.6 %
Brugia malayi ORL1-like opioid receptor Delta opioid receptor   372 aa 300 aa 24.7 %
Brugia malayi GnHR receptor homolog Delta opioid receptor   372 aa 313 aa 18.5 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Mu opioid receptor   398 aa 334 aa 23.1 %
Echinococcus multilocularis allatostatin A receptor Delta opioid receptor   372 aa 302 aa 28.5 %
Onchocerca volvulus Delta opioid receptor   372 aa 353 aa 21.0 %
Onchocerca volvulus Programmed cell death protein 5 homolog Mu opioid receptor   398 aa 323 aa 24.1 %
Onchocerca volvulus Phosphoinositide 3-kinase adapter subunit homolog Kappa opioid receptor   380 aa 323 aa 22.6 %
Echinococcus granulosus thyrotropin releasing hormone receptor Delta opioid receptor   372 aa 330 aa 24.5 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Mu opioid receptor   398 aa 397 aa 22.7 %
Schistosoma mansoni peptide (allatostatin)-like receptor Delta opioid receptor   372 aa 353 aa 29.2 %
Schistosoma mansoni neuropeptide F-like receptor Mu opioid receptor   398 aa 335 aa 20.6 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Delta opioid receptor   372 aa 366 aa 22.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Brugia malayi RE15519p 0.0021 0.0045 0.0097
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0476 0.0476
Schistosoma mansoni ap endonuclease 0.002 0.0038 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.049 0.2056
Echinococcus multilocularis serotonin receptor 0.0021 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0033 0.0172 0.0366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0309 0.1298
Toxoplasma gondii cathepsin CPL 0.0252 0.2382 1
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Brugia malayi Cathepsin L-like precursor 0.0173 0.1583 0.3377
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0411 0.1726
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.1298 0.277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0129 0.0542
Onchocerca volvulus 0.0028 0.012 0.0321
Trypanosoma cruzi cysteine peptidase, putative 0.0252 0.2382 0.5082
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0087 0.0716 0.2893
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0301 0.1123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.049 0.2056
Brugia malayi G protein-coupled receptor 0.0021 0.0045 0.0097
Toxoplasma gondii cathepsin CPC2 0.0057 0.0411 0.1726
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Toxoplasma gondii LsmAD domain-containing protein 0.0105 0.0897 0.3768
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0352 0.3394 0.7241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0361 0.1514
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0001 0.0002
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0045 0.0045
Echinococcus granulosus cathepsin b 0.0479 0.4687 0.4687
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Schistosoma mansoni transcription factor LCR-F1 0.0221 0.2067 0.299
Echinococcus granulosus chromobox protein 1 0.008 0.0641 0.0641
Brugia malayi G-protein coupled receptor 0.0021 0.0045 0.0097
Onchocerca volvulus 0.0252 0.2382 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0252 0.2382 1
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Echinococcus granulosus dnaJ subfamily B 0.0404 0.3924 0.3924
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.032 0.1177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.049 0.2056
Loa Loa (eye worm) cathepsin B 0.0188 0.1734 0.3699
Plasmodium vivax ataxin-2 like protein, putative 0.0105 0.0897 0.3667
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0057 0.0411 0.0595
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0038 1
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0045 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.049 0.2056
Brugia malayi sulfakinin receptor protein 0.0021 0.0045 0.0097
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0038 0.0407
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0127 0.0533
Echinococcus granulosus microtubule associated protein 2 0.0699 0.6913 0.6913
Schistosoma mansoni smad1 5 8 and 0.0024 0.0076 0.0109
Giardia lamblia Hypothetical protein 0.0057 0.0411 0.2202
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0057 0.0411 0.1593
Trypanosoma brucei PAB1-binding protein , putative 0.0105 0.0897 0.3768
Echinococcus granulosus GPCR family 2 0.0033 0.0172 0.0172
Plasmodium falciparum serine repeat antigen 3 0.0057 0.0411 0.1593
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.031 0.1301
Brugia malayi putative neuropeptide receptor NPR1 0.0021 0.0045 0.0097
Onchocerca volvulus 0.0043 0.0267 0.0948
Schistosoma mansoni hypothetical protein 0.0021 0.0045 0.0066
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Brugia malayi follicle stimulating hormone receptor 0.0021 0.0045 0.0097
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0921 0.3867
Onchocerca volvulus 0.0232 0.2183 0.9148
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0021 0.0045 0.0097
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0252 0.2382 0.2382
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0565 0.1205
Echinococcus granulosus cathepsin L cysteine proteinase 0.0252 0.2382 0.2382
Schistosoma mansoni neuropeptide receptor 0.0021 0.0045 0.0066
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0018 0.0019 0.008
Loa Loa (eye worm) TYRA-2 protein 0.0021 0.0045 0.0097
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0057 0.0411 0.1593
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0045 0.0066
Trichomonas vaginalis chromobox protein, putative 0.0048 0.032 0.1345
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0252 0.2382 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0057 0.0411 0.1593
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0044 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Schistosoma mansoni biogenic amine receptor 0.0021 0.0045 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0017 0 0.0001
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0252 0.2382 0.5082
Plasmodium falciparum serine repeat antigen 5 0.0057 0.0411 0.1593
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0057 0.0411 0.1593
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0921 0.3867
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Echinococcus granulosus cathepsin L 0.0136 0.121 0.121
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0301 0.1263
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0021 0.0045 0.0066
Schistosoma mansoni hypothetical protein 0.0221 0.2067 0.299
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0252 0.2382 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0057 0.0411 0.0595
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0021 0.0045 0.0045
Brugia malayi CHD4 protein 0.0017 0.0001 0.0001
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0136 0.121 0.1751
Loa Loa (eye worm) melatonin receptor type 1A 0.0021 0.0045 0.0097
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1898 0.405
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0038 0.0158
Schistosoma mansoni neuropeptide f receptor 76f 0.0021 0.0045 0.0066
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Echinococcus granulosus cathepsin l1 0.0173 0.1583 0.1583
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0029 0.0129 0.039
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0038 0.0081
Trypanosoma cruzi target of rapamycin kinase 3 0.0069 0.0536 0.1144
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0301 0.1263
Echinococcus multilocularis chromobox protein 1 0.008 0.0641 0.0641
Plasmodium vivax unspecified product 0.0136 0.121 0.5001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0136 0.121 0.5081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0057 0.0411 0.1726
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0411 0.1726
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0021 0.0045 0.0097
Leishmania major cathepsin L-like protease 0.0252 0.2382 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0535 0.2247
Giardia lamblia Cathepsin L precursor 0.0057 0.0411 0.2202
Giardia lamblia Cysteine protease 0.0057 0.0411 0.2202
Giardia lamblia Cathepsin B precursor 0.0188 0.1734 1
Brugia malayi neuropeptide F receptor 0.0021 0.0045 0.0097
Brugia malayi Cathepsin L-like precursor 0.0252 0.2382 0.5082
Schistosoma mansoni growth hormone secretagogue receptor 0.0021 0.0045 0.0066
Schistosoma mansoni hypothetical protein 0.0033 0.0172 0.0248
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0127 0.0533
Trypanosoma cruzi cysteine proteinase, putative 0.0136 0.121 0.2582
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0045 0.0097
Giardia lamblia Cathepsin B precursor 0.0057 0.0411 0.2202
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0129 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.049 0.2056
Plasmodium falciparum ataxin-2 like protein, putative 0.0105 0.0897 0.3667
Echinococcus granulosus neuropeptide FF receptor 2 0.0021 0.0045 0.0045
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0127 0.0533
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0057 0.0411 0.1593
Schistosoma mansoni cathepsin F (C01 family) 0.0252 0.2382 0.3446
Schistosoma mansoni microtubule-associated protein tau 0.0699 0.6913 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0045 0.0045
Entamoeba histolytica cysteine protease, putative 0.0057 0.0411 0.1726
Echinococcus granulosus g protein coupled receptor 0.0021 0.0045 0.0045
Brugia malayi PHD-finger family protein 0.003 0.0132 0.0282
Echinococcus granulosus alpha 1A adrenergic receptor 0.0021 0.0045 0.0045
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Giardia lamblia Cathepsin B precursor 0.0057 0.0411 0.2202
Plasmodium falciparum serine repeat antigen 9 0.0057 0.0411 0.1593
Loa Loa (eye worm) hypothetical protein 0.0057 0.0411 0.0877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0535 0.2247
Loa Loa (eye worm) hypothetical protein 0.0057 0.0411 0.0877
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0087 0.0716 0.1528
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0411 0.0877
Schistosoma mansoni cathepsin F (C01 family) 0.0173 0.1583 0.229
Echinococcus multilocularis somatostatin receptor 0.0021 0.0045 0.0045
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0057 0.0411 0.1593
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0038 0.0158
Giardia lamblia Cathepsin L precursor 0.0057 0.0411 0.2202
Plasmodium vivax serine-repeat antigen (SERA) 0.0057 0.0411 0.1593
Schistosoma mansoni opsin-like receptor 0.0021 0.0045 0.0066
Onchocerca volvulus 0.0252 0.2382 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0076 0.0076
Echinococcus multilocularis cysteine protease 0.0252 0.2382 0.2382
Schistosoma mansoni ap endonuclease 0.002 0.0038 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0029 0.0129 0.0542
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0021 0.0045 0.0066
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0411 0.0595
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0045 0.0045
Echinococcus granulosus sex peptide receptor 0.0021 0.0045 0.0045
Brugia malayi cathepsin F-like cysteine proteinase 0.0057 0.0411 0.0877
Brugia malayi Tachykinin-like peptides receptor 99D 0.0021 0.0045 0.0097
Brugia malayi Cathepsin L-like precursor 0.0173 0.1583 0.3377
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0021 0.0045 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0043 0.0272 0.058
Plasmodium vivax vivapain-3 0.0136 0.121 0.5001
Plasmodium vivax unspecified product 0.0079 0.0632 0.2535
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0045 0.0045
Trichomonas vaginalis set domain proteins, putative 0.0232 0.2183 0.9164
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0479 0.4687 0.6781
Brugia malayi cathepsin L precursor 0.0057 0.0411 0.0877
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0021 0.0045 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0252 0.2382 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0021 0.0045 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0406 0.1705
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0036 0.02 0.0839
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0057 0.0411 0.1726
Brugia malayi Papain family cysteine protease containing protein 0.0057 0.0411 0.0877
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0127 0.0381
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Trypanosoma cruzi cysteine protease, putative 0.0136 0.121 0.2582
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0173 0.1583 0.6646
Trypanosoma cruzi cysteine proteinase, putative 0.0136 0.121 0.2582
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0301 0.1263
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0057 0.0411 0.1726
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.049 0.2056
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Brugia malayi Cathepsin L-like precursor 0.0252 0.2382 0.5082
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0127 0.0533
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0127 0.0533
Brugia malayi Papain family cysteine protease containing protein 0.0252 0.2382 0.5082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0411 0.1726
Onchocerca volvulus 0.0057 0.0411 0.1566
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0001 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Brugia malayi Smad1 0.0024 0.0076 0.0161
Schistosoma mansoni amine GPCR 0.0021 0.0045 0.0066
Leishmania major cathepsin L-like protease 0.0252 0.2382 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0127
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0057 0.0411 0.0595
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0038 0.0038
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0046 0.0303 0.0646
Schistosoma mansoni hypothetical protein 0.0021 0.0045 0.0066
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Brugia malayi Papain family cysteine protease containing protein 0.0136 0.121 0.2582
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0021 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0173 0.1583 0.6646
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Brugia malayi Pre-SET motif family protein 0.0204 0.1898 0.405
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0057 0.0411 0.1726
Schistosoma mansoni smad1 5 8 and 0.0024 0.0076 0.0109
Schistosoma mansoni chromobox protein 0.008 0.0641 0.0928
Trichomonas vaginalis chromobox protein, putative 0.008 0.0641 0.2692
Loa Loa (eye worm) hypothetical protein 0.0147 0.1321 0.2819
Echinococcus granulosus dro:myosuppressin receptor 0.0021 0.0045 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0267 0.0386
Entamoeba histolytica hypothetical protein 0.0057 0.0411 0.1726
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Trichomonas vaginalis chromobox protein, putative 0.0048 0.032 0.1345
Schistosoma mansoni hypothetical protein 0.0021 0.0045 0.0066
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0172 0.0172
Schistosoma mansoni alpha-1 adrenergic receptor 0.0021 0.0045 0.0066
Onchocerca volvulus Cathepsin L homolog 0.0057 0.0411 0.1566
Loa Loa (eye worm) hypothetical protein 0.0037 0.0212 0.0451
Plasmodium falciparum serine repeat antigen 8 0.0057 0.0411 0.1593
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0045 0.0066
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.1298 0.1298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0309 0.1298
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Plasmodium vivax unspecified product 0.0057 0.0411 0.1593
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.121 0.5081
Echinococcus granulosus g protein coupled receptor 0.0021 0.0045 0.0045
Trypanosoma cruzi cruzipain precursor, putative 0.0252 0.2382 0.5082
Leishmania major cathepsin L-like protease 0.0252 0.2382 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0172 0.0172
Plasmodium vivax vivapain-1 0.0136 0.121 0.5001
Loa Loa (eye worm) hypothetical protein 0.0079 0.0632 0.1348
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0127 0.0381
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0021 0.0045 0.0045
Echinococcus multilocularis zinc finger protein 0.0024 0.008 0.008
Brugia malayi Cathepsin L-like precursor 0.0252 0.2382 0.5082
Schistosoma mansoni hypothetical protein 0.0033 0.0172 0.0248
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0021 0.0045 0.0066
Entamoeba histolytica cysteine proteinase, putative 0.0252 0.2382 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0303 0.0438
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0411 0.0877
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0921 0.3867
Leishmania major cathepsin L-like protease 0.0252 0.2382 1
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0921 0.1332
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0072 0.0072
Entamoeba histolytica hypothetical protein 0.0221 0.2067 0.8678
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0632 0.1348
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0411 0.1726
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0921 0.0921
Plasmodium falciparum serine repeat antigen 7 0.0057 0.0411 0.1593
Echinococcus granulosus fmrfamide receptor 0.0021 0.0045 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0309 0.1298
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0069 0.0536 0.225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0019 0.008
Echinococcus granulosus cysteine protease 0.0136 0.121 0.121
Echinococcus multilocularis neuropeptide receptor A26 0.0021 0.0045 0.0045
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0127 0.0381
Loa Loa (eye worm) hypothetical protein 0.0105 0.0897 0.1915
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0127 0.0533
Brugia malayi Cathepsin L-like precursor 0.0252 0.2382 0.5082
Echinococcus multilocularis cathepsin L cysteine protease 0.0252 0.2382 0.2382
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0136 0.121 0.5081
Echinococcus multilocularis chromobox protein 1 0.008 0.0641 0.0641
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.121 0.5081
Echinococcus multilocularis serotonin receptor 0.0021 0.0045 0.0045
Schistosoma mansoni cathepsin F (C01 family) 0.0252 0.2382 0.3446
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0045 0.0045
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0045 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Schistosoma mansoni amine GPCR 0.0021 0.0045 0.0066
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0045 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0129 0.0542
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.012 0.0257
Schistosoma mansoni cellular tumor antigen P53 0.0147 0.1321 0.1911
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0045 0.0066
Schistosoma mansoni hypothetical protein 0.0182 0.1678 0.2427
Brugia malayi putative neuropeptide receptor 0.0021 0.0045 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0535 0.2247
Entamoeba histolytica cysteine proteinase 2 0.0136 0.121 0.5081
Echinococcus multilocularis cathepsin b 0.0479 0.4687 0.4687
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0057 0.0411 0.1726
Schistosoma mansoni amine GPCR 0.0021 0.0045 0.0066
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0136 0.121 0.1751
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0921 0.3867
Loa Loa (eye worm) ctsf protein 0.0252 0.2382 0.5082
Giardia lamblia Cysteine protease 0.0057 0.0411 0.2202
Brugia malayi MH2 domain containing protein 0.0024 0.0076 0.0161
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0301 0.1263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0355 0.1492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0355 0.1492
Onchocerca volvulus 0.0252 0.2382 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0021 0.0045 0.0097
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0136 0.121 0.1751
Schistosoma mansoni Smad4 0.0024 0.0076 0.0109
Schistosoma mansoni smad 0.0024 0.0076 0.0109
Giardia lamblia Cathepsin L precursor 0.0057 0.0411 0.2202
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0252 0.2382 1
Loa Loa (eye worm) hypothetical protein 0.0173 0.1583 0.3377
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.1298 0.1298
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0021 0.0045 0.0097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0135 0.0195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0045 0.0066
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0029 0.0129 0.0187
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0921 0.1965
Schistosoma mansoni opsin-like receptor 0.0021 0.0045 0.0066
Brugia malayi GnHR receptor homolog 0.0021 0.0045 0.0097
Brugia malayi hypothetical protein 0.0105 0.0897 0.1915
Brugia malayi MH2 domain containing protein 0.0352 0.3394 0.7241
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0135 0.0135
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0038 0.0038
Schistosoma mansoni cpg binding protein 0.0028 0.012 0.0174
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0172 0.0172
Loa Loa (eye worm) phosphatidylinositol 3 0.0029 0.0129 0.0275
Loa Loa (eye worm) hypothetical protein 0.0479 0.4687 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0903 0.1927
Giardia lamblia Cathepsin B precursor 0.0057 0.0411 0.2202
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0127 0.0533
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0535 0.2247
Onchocerca volvulus 0.0252 0.2382 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0188 0.1734 0.7279
Schistosoma mansoni chromobox protein 0.008 0.0641 0.0928
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0028
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0045 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0154 0.0646
Echinococcus multilocularis cathepsin b 0.0479 0.4687 0.4687
Entamoeba histolytica cysteine protease, putative 0.0252 0.2382 1
Brugia malayi hypothetical protein 0.0221 0.2067 0.441
Entamoeba histolytica cysteine protease, putative 0.0057 0.0411 0.1726
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0001 0.0001
Echinococcus granulosus cpg binding protein 0.0032 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Entamoeba histolytica cysteine proteinase, putative 0.0173 0.1583 0.6646
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0037 0.0078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0252 0.2382 1
Loa Loa (eye worm) fibroinase 0.0252 0.2382 0.5082
Loa Loa (eye worm) hypothetical protein 0.0057 0.0411 0.0877
Entamoeba histolytica cysteine proteinase, putative 0.0252 0.2382 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.0716 0.3006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1298 0.1878
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0252 0.2382 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0136 0.121 0.5081
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0172 0.0366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Trypanosoma cruzi cysteine peptidase, putative 0.0252 0.2382 0.5082
Brugia malayi Cathepsin L-like precursor 0.0079 0.0632 0.1348
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0135 0.0565
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0479 0.4687 0.6781
Loa Loa (eye worm) hypothetical protein 0.0057 0.0411 0.0877
Loa Loa (eye worm) hypothetical protein 0.0057 0.0411 0.0877
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0479 0.4687 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Plasmodium falciparum cysteine proteinase falcipain 1 0.0136 0.121 0.5001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0129 0.0542
Brugia malayi Cathepsin L-like precursor 0.0252 0.2382 0.5082
Echinococcus granulosus hypothetical protein 0.0021 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0045 0.0045
Schistosoma mansoni cathepsin B (C01 family) 0.0057 0.0411 0.0595
Echinococcus multilocularis neuropeptide s receptor 0.0021 0.0045 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.031 0.1301
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0045 0.0045
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.003 0.0127
Schistosoma mansoni hypothetical protein 0.0033 0.0172 0.0248
Giardia lamblia Cathepsin B precursor 0.0188 0.1734 1
Echinococcus granulosus neuropeptide receptor A26 0.0021 0.0045 0.0045
Brugia malayi Melatonin receptor type 1A 0.0021 0.0045 0.0097
Toxoplasma gondii exonuclease III APE 0.002 0.0038 0.0158
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0252 0.2382 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0921 1
Echinococcus multilocularis cysteine protease 0.0252 0.2382 0.2382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0425 0.1785
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0045 0.0066
Loa Loa (eye worm) hypothetical protein 0.0072 0.0565 0.1205
Echinococcus granulosus tachykinin peptides receptor 99D 0.0021 0.0045 0.0045
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0021 0.0045 0.0097
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0921 0.3867
Onchocerca volvulus 0.0173 0.1583 0.6581
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0221 0.2067 0.2067
Brugia malayi G-protein coupled receptor 0.0021 0.0045 0.0097
Brugia malayi Papain family cysteine protease containing protein 0.0057 0.0411 0.0877
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0087 0.0716 0.1036
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0172 0.0366
Plasmodium vivax vivapain-2 0.0252 0.2382 1
Onchocerca volvulus 0.0035 0.0188 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0129 0.0542
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.121 0.2582
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0045 0.0045
Echinococcus granulosus orexin receptor type 2 0.0021 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0045 0.0286 0.061
Echinococcus granulosus neuropeptide s receptor 0.0021 0.0045 0.0045
Brugia malayi Serotonin receptor 0.0021 0.0045 0.0097
Echinococcus granulosus Smad4 0.0024 0.0076 0.0076
Giardia lamblia Cathepsin B precursor 0.0057 0.0411 0.2202
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0045 0.0045
Onchocerca volvulus 0.0147 0.1321 0.546
Brugia malayi Bromodomain containing protein 0.0041 0.0248 0.0529
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0045 0.0045
Leishmania major cathepsin L-like protease 0.0252 0.2382 1
Brugia malayi Bromodomain containing protein 0.0078 0.0626 0.1337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0361 0.1514
Echinococcus multilocularis GPCR, family 2 0.0033 0.0172 0.0172
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0921 0.3768
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Trichomonas vaginalis chromobox protein, putative 0.008 0.0641 0.2692
Schistosoma mansoni hypothetical protein 0.0182 0.1678 0.2427
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0029 0.0129 0.0275
Brugia malayi Serotonin receptor 0.0021 0.0045 0.0097
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Giardia lamblia Cathepsin L precursor 0.0057 0.0411 0.2202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0361 0.1514
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Echinococcus multilocularis neuropeptide FF receptor 2 0.0021 0.0045 0.0045
Brugia malayi Cathepsin L-like precursor 0.0252 0.2382 0.5082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Onchocerca volvulus 0.0252 0.2382 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0076 0.0161
Loa Loa (eye worm) hypothetical protein 0.0069 0.0531 0.1133
Leishmania major cathepsin L-like protease 0.0252 0.2382 1
Schistosoma mansoni cathepsin S (C01 family) 0.0057 0.0411 0.0595
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0045 0.0066
Schistosoma mansoni myosin xvIII 0.0021 0.0045 0.0066
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0057 0.0411 0.1593
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0045 0.0097
Echinococcus multilocularis microtubule associated protein 2 0.0699 0.6913 0.6913
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0038 0.0158
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0038 0.0081
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0045 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0411 0.1726
Echinococcus granulosus peptide allatostatin:somatostatin 0.0021 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0117 0.0117
Loa Loa (eye worm) acetyltransferase 0.0152 0.1368 0.2919
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0021 0.0045 0.0066
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Brugia malayi MH1 domain containing protein 0.0024 0.0076 0.0161
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0045 0.0045
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0045 0.0045
Toxoplasma gondii target of rapamycin (TOR), putative 0.0065 0.049 0.2056
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0029 0.0129 0.0275
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0479 0.4687 0.6781
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0921 0.1965
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1298 0.1878
Brugia malayi G protein-coupled receptor F59B2.13 0.0021 0.0045 0.0097
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0021 0.0045 0.0097
Echinococcus granulosus neuropeptide receptor 0.0021 0.0045 0.0045
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0038 0.0081
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0127 0.0381
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0021 0.0045 0.0066
Echinococcus multilocularis cathepsin L 0.0057 0.0411 0.0411
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Schistosoma mansoni fkbp-rapamycin associated protein 0.0016 0.00000001237 0.000000017895
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0057 0.0411 0.2202
Echinococcus granulosus serotonin receptor 0.0021 0.0045 0.0045
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0087 0.0716 0.3006
Schistosoma mansoni zinc finger protein 0.0024 0.008 0.0115
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0301 0.0301
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0127 0.0533
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0072 0.0104
Giardia lamblia Cathepsin L-like protease 0.0057 0.0411 0.2202
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0021 0.0045 0.0066
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0903 0.1927
Schistosoma mansoni cathepsin s 0.0079 0.0632 0.0914
Giardia lamblia Cathepsin B precursor 0.0057 0.0411 0.2202
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0072 0.0072
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0411 0.0595
Loa Loa (eye worm) Smad1 0.0024 0.0076 0.0161
Schistosoma mansoni bromodomain containing protein 0.0067 0.0511 0.0739
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0045 0.0097
Plasmodium falciparum serine repeat antigen 1 0.0057 0.0411 0.1593
Echinococcus granulosus smad 0.0024 0.0076 0.0076
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0286 0.103
Loa Loa (eye worm) hypothetical protein 0.0035 0.0188 0.0401
Brugia malayi Dopamine receptor protein 2 0.0021 0.0045 0.0097
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0001 0.0001
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0001 0.0001
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0057 0.0411 0.1593
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0286 0.1201
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0188 0.0188
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0535 0.2247
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0057 0.0411 0.1593
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0057 0.0411 0.1726
Echinococcus granulosus allatostatin A receptor 0.0021 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Loa Loa (eye worm) hypothetical protein 0.0047 0.0307 0.0655
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0076 0.0076
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0252 0.2382 1
Plasmodium falciparum serine repeat antigen 2 0.0057 0.0411 0.1593
Trypanosoma cruzi PAB1-binding protein , putative 0.0105 0.0897 0.1915
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0411 0.1726
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0079 0.0632 0.1348
Echinococcus granulosus chromobox protein 1 0.008 0.0641 0.0641
Echinococcus multilocularis G-protein coupled receptor, putative 0.0021 0.0045 0.0045
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0018 0.0019 0.0041
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0252 0.2382 0.5082
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0021 0.0045 0.0045
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0001 0.0001
Echinococcus multilocularis g-protein coupled receptor 0.0021 0.0045 0.0045
Echinococcus granulosus g-protein coupled receptor 0.0021 0.0045 0.0045
Brugia malayi CXXC zinc finger family protein 0.0028 0.012 0.0257
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0021 0.0045 0.0097
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0411 0.0595
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0045 0.0045
Echinococcus granulosus 7TM GPCR rhodopsin 0.0021 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Echinococcus granulosus cathepsin L cysteine protease 0.0136 0.121 0.121
Plasmodium falciparum ataxin-2 like protein, putative 0.0105 0.0897 0.3667
Plasmodium falciparum serine repeat antigen 6 0.0057 0.0411 0.1593
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.031 0.1301
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0021 0.0045 0.0045
Echinococcus granulosus neuropeptide receptor 0.0021 0.0045 0.0045
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0087 0.0716 0.3006
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0087 0.0716 0.0716
Brugia malayi hypothetical protein 0.0068 0.052 0.111
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0045 0.0045
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0021 0.0045 0.0066
Brugia malayi Dopamine receptor 0.0021 0.0045 0.0097
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0172 0.0366
Schistosoma mansoni cpg binding protein 0.0032 0.0155 0.0225
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0045 0.0097
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Plasmodium vivax serine-repeat antigen (SERA) 0.0057 0.0411 0.1593
Loa Loa (eye worm) hypothetical protein 0.0252 0.2382 0.5082
Schistosoma mansoni opsin-like receptor 0.0021 0.0045 0.0066
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0173 0.1583 0.3377
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0057 0.0411 0.1593
Giardia lamblia Cysteine protease 0.0057 0.0411 0.2202
Trichomonas vaginalis ferritin, putative 0.0017 0 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0411 0.1726
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0076 0.0161
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0127 0.5
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0057 0.0411 0.0877
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0057 0.0411 0.1726
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Loa Loa (eye worm) transcription factor SMAD2 0.0352 0.3394 0.7241
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0453 0.0656
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0057 0.0411 0.1593
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0045 0.0066
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0045 0.0066
Brugia malayi Papain family cysteine protease containing protein 0.0136 0.121 0.2582
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0479 0.4687 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0252 0.2382 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0411 0.1726
Entamoeba histolytica hypothetical protein 0.0221 0.2067 0.8678
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0087 0.0716 0.0716
Leishmania major hypothetical protein, conserved 0.0105 0.0897 0.3667
Schistosoma mansoni amine GPCR 0.0021 0.0045 0.0066
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0038 0.0407
Schistosoma mansoni smad1 5 8 and 0.0024 0.0076 0.0109
Trypanosoma cruzi cysteine peptidase, putative 0.0252 0.2382 0.5082
Loa Loa (eye worm) cysteine protease 0.0252 0.2382 0.5082
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0029 0.0129 0.0542
Entamoeba histolytica cysteine protease, putative 0.0057 0.0411 0.1726
Echinococcus granulosus zinc finger protein 0.0024 0.008 0.008
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0411 0.0595
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0127
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0057 0.0411 0.1593
Entamoeba histolytica cysteine protease, putative 0.0057 0.0411 0.1726
Echinococcus multilocularis Smad4 0.0024 0.0076 0.0076
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0045 0.0066
Brugia malayi neuropeptide F receptor 0.0021 0.0045 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0021 0.0045 0.0045
Giardia lamblia Cysteine protease 0.0057 0.0411 0.2202
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0188 0.1734 0.3699
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0057 0.0411 0.2202
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0127 0.5
Giardia lamblia Cathepsin L precursor 0.0057 0.0411 0.2202
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0057 0.0411 0.0877
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0241 0.0865
Echinococcus granulosus somatostatin receptor 0.0021 0.0045 0.0045
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.121 0.5081
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0127 0.0533
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0411 0.1726
Giardia lamblia GTOR 0.0087 0.0716 0.3999
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0136 0.121 0.2582
Loa Loa (eye worm) hypothetical protein 0.0173 0.1583 0.3377
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1298 0.1878
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0476 0.0476
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.1368 0.1368
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0029 0.0129 0.0129
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0127
Toxoplasma gondii cathepsin B 0.0188 0.1734 0.7279
Schistosoma mansoni adenoreceptor 0.0021 0.0045 0.0066
Schistosoma mansoni neuropeptide receptor 0.0021 0.0045 0.0066
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.031 0.031
Giardia lamblia Cathepsin B precursor 0.0188 0.1734 1
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0921 0.1332
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0045 0.0066
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.031 0.031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0303 0.0438
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.049 0.2056
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0045 0.0066
Echinococcus multilocularis geminin 0.0182 0.1678 0.1678
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0404 0.3924 0.5677
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0045 0.0045
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0045 0.0045
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0021 0.0045 0.0066
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0033 0.0172 0.0248
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0221 0.2067 0.2067
Plasmodium vivax vivapain-2 0.0252 0.2382 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0038 0.0407
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0241 0.101
Brugia malayi cathepsin Z-like cysteine proteinase 0.0057 0.0411 0.0877
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Brugia malayi 6-phosphofructokinase 0.0107 0.0921 0.1965
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0921 0.3867
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Echinococcus multilocularis tumor protein p63 0.1004 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0154 0.0646
Trypanosoma cruzi cruzipain precursor, putative 0.0079 0.0632 0.1348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.007 0.0293
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0929 0.924 0.924
Giardia lamblia Cathepsin L-like protease 0.0057 0.0411 0.2202
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0127 0.1375
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0921 1
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Echinococcus multilocularis sex peptide receptor 0.0021 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0057 0.0411 0.1726
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.1298 0.277
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0 0.0001
Echinococcus multilocularis allatostatin A receptor 0.0021 0.0045 0.0045
Brugia malayi ORL1-like opioid receptor 0.0021 0.0045 0.0097
Toxoplasma gondii preprocathepsin c precursor, putative 0.0057 0.0411 0.1726
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0241 0.1196
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0903 0.1927
Brugia malayi Cathepsin L-like cysteine proteinase 0.0173 0.1583 0.3377
Echinococcus granulosus cathepsin L 0.0057 0.0411 0.0411
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0127
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0188 0.1734 0.7235
Schistosoma mansoni neuropeptide receptor 0.0021 0.0045 0.0066
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0087 0.0716 0.3006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.1368 0.1979
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0921 1
Echinococcus multilocularis orexin receptor type 2 0.0021 0.0045 0.0045
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0921 1
Brugia malayi MH1 domain containing protein 0.0024 0.0076 0.0161
Loa Loa (eye worm) phosphatidylinositol 3 0.0087 0.0716 0.1528
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0087 0.0716 0.1528
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Plasmodium falciparum serine repeat antigen 4 0.0057 0.0411 0.1593
Schistosoma mansoni cathepsin C 0.0057 0.0411 0.0595
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0021 0.0045 0.0045
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0921 0.1965
Echinococcus multilocularis G protein coupled receptor 139 0.0021 0.0045 0.0045
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0188 0.1734 0.2508
Entamoeba histolytica hypothetical protein 0.0221 0.2067 0.8678
Brugia malayi chromobox protein homolog 3 0.0045 0.0286 0.061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0479 0.4687 0.6781
Echinococcus multilocularis cpg binding protein 0.0032 0.0155 0.0155
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0057 0.0411 0.1593
Onchocerca volvulus Cathepsin L homolog 0.0252 0.2382 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0303 0.0303
Schistosoma mansoni amine GPCR 0.0021 0.0045 0.0066
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0411 0.0595
Entamoeba histolytica hypothetical protein 0.0221 0.2067 0.8678
Echinococcus multilocularis smad 0.0024 0.0076 0.0076
Entamoeba histolytica cysteine protease, putative 0.0057 0.0411 0.1726
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0087 0.0716 0.1528
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.121 0.5081
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0029 0.0129 0.0275
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0127 0.0533
Echinococcus granulosus g protein coupled receptor 0.0021 0.0045 0.0045
Brugia malayi Heterochromatin protein 1 0.008 0.0641 0.1368
Brugia malayi cathepsin Z-like cysteine proteinase 0.0057 0.0411 0.0877
Schistosoma mansoni cpg binding protein 0.0032 0.0155 0.0225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0252 0.2382 1
Schistosoma mansoni hypothetical protein 0.0072 0.0565 0.0817
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.003 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.0716 0.3006
Onchocerca volvulus 0.0252 0.2382 1
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.121 0.5081
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0021 0.0045 0.0066
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0045 0.0045
Echinococcus granulosus cathepsin l1 0.0252 0.2382 0.2382
Leishmania major cathepsin L-like protease 0.0252 0.2382 1
Schistosoma mansoni neuropeptide receptor 0.0021 0.0045 0.0066
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0252 0.2382 1
Onchocerca volvulus Cathepsin F homolog 0.0252 0.2382 1
Brugia malayi larval opioid receptor 0.0021 0.0045 0.0097
Onchocerca volvulus 0.0252 0.2382 1
Brugia malayi Dopamine receptor protein 1 0.0021 0.0045 0.0097
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0057 0.0411 0.0595
Loa Loa (eye worm) hypothetical protein 0.0106 0.0903 0.1927
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0045 0.0066
Echinococcus multilocularis dro:myosuppressin receptor 0.0021 0.0045 0.0045
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0001 0.0001
Echinococcus granulosus cathepsin l cysteine peptidase 0.0252 0.2382 0.2382
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0057 0.0411 0.1726
Schistosoma mansoni histamine h1 receptor 0.0021 0.0045 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.031 0.1301
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0172 0.0172
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0087 0.0716 0.3006
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0921 0.3867
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0057 0.0411 0.1726
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0252 0.2382 0.2382
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0045 0.0066
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0021 0.0045 0.0097
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0057 0.0411 0.2202
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0646 0.6373 0.6373
Brugia malayi cathepsin F-like cysteine proteinase 0.0079 0.0632 0.1348
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0449 0.1883
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0021 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0411 0.1726
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Trypanosoma cruzi cysteine peptidase, putative 0.0252 0.2382 0.5082
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0045 0.0066
Loa Loa (eye worm) hypothetical protein 0.0173 0.1583 0.3377
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0411 0.1726
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0127 0.0533
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0045 0.0045
Brugia malayi AKH receptor 0.0021 0.0045 0.0097
Toxoplasma gondii cathepsin CPC1 0.0057 0.0411 0.1726
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0057 0.0411 0.0877
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0076 0.0109
Trypanosoma brucei cysteine peptidase C (CPC) 0.0188 0.1734 0.7279
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Echinococcus granulosus tm gpcr rhodopsin 0.0646 0.6373 0.6373
Brugia malayi 6-phosphofructokinase 0.0107 0.0921 0.1965
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0021 0.0045 0.0097
Brugia malayi cathepsin L-like cysteine proteinase 0.0057 0.0411 0.0877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0587 0.2464
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0252 0.2382 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0252 0.2382 0.2382
Giardia lamblia Cathepsin L precursor 0.0057 0.0411 0.2202
Echinococcus granulosus geminin 0.0182 0.1678 0.1678
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0021 0.0045 0.0097
Schistosoma mansoni biogenic amine receptor 0.0021 0.0045 0.0066
Brugia malayi Papain family cysteine protease containing protein 0.0057 0.0411 0.0877
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0921 0.3867
Brugia malayi phosphofructokinase 0.0107 0.0921 0.1965
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0045 0.0045
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.121 0.5081
Brugia malayi fibroinase precursor 0.0057 0.0411 0.0877
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.1302 0.1302
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0076 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0045 0.0066
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0029 0.0129 0.0129
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0057 0.0411 0.0877
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Echinococcus granulosus cathepsin b 0.0479 0.4687 0.4687
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.1368 0.2919
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Giardia lamblia Encystation-specific protease 0.0057 0.0411 0.2202
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0069 0.0536 0.2126
Brugia malayi cathepsin L-like precursor 0.0173 0.1583 0.3377
Leishmania major phosphatidylinositol 3-kinase, putative 0.0029 0.0129 0.039
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0188 0.0188
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0041 0.0251 0.1052
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0045 0.0045
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0045 0.0045
Onchocerca volvulus Cathepsin L homolog 0.0252 0.2382 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0632 0.1348
Trypanosoma cruzi PAB1-binding protein , putative 0.0105 0.0897 0.1915
Brugia malayi MH2 domain containing protein 0.0024 0.0076 0.0161
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0921 0.0921
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0057 0.0411 0.2202
Schistosoma mansoni biogenic amine receptor 0.0021 0.0045 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0286 0.1201
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0021 0.0045 0.0045
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0045 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0252 0.2382 1
Plasmodium vivax SET domain protein, putative 0.003 0.0135 0.0413
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0087 0.0716 0.2893
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0038 0.0081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.1298 0.1298
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0127 0.0526
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.3924 0.3924
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0079 0.0632 0.1348
Schistosoma mansoni hypothetical protein 0.0047 0.031 0.0449
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.0716 0.3006
Echinococcus granulosus G protein coupled receptor 139 0.0021 0.0045 0.0045
Leishmania major cysteine peptidase A (CPA) 0.0252 0.2382 1
Loa Loa (eye worm) heterochromatin protein 1 0.008 0.0641 0.1368
Giardia lamblia Hypothetical protein 0.0057 0.0411 0.2202
Loa Loa (eye worm) hypothetical protein 0.0079 0.0632 0.1348
Brugia malayi Pre-SET motif family protein 0.003 0.0135 0.0287
Loa Loa (eye worm) hypothetical protein 0.0057 0.0411 0.0877
Echinococcus multilocularis cathepsin L 0.0136 0.121 0.121
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0921 0.1965
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0038 0.0158
Entamoeba histolytica cysteine protease, putative 0.0057 0.0411 0.1726
Leishmania major cathepsin L-like protease 0.0252 0.2382 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.1298 0.1298
Schistosoma mansoni hypothetical protein 0.002 0.0037 0.0053

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 56.1 nM Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of rat brain membranes ChEMBL. 9599247
Ki (binding) = 388 nM Inhibition of [3H]U69,593 binding to Opioid receptor kappa 1 of guinea pig membranes ChEMBL. 9599247
Ki (binding) = 827 nM Inhibition of [3H]-DADLE binding to Opioid receptor delta 1 of rat brain membranes ChEMBL. 9599247

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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