Detailed information for compound 938797

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 335.482 | Formula: C23H29NO
  • H donors: 1 H acceptors: 1 LogP: 5.26 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cccc(c1)[C@]1(C)CCN(C[C@@H]1C)C[C@@H]1C[C@H]1c1ccccc1
  • InChi: 1S/C23H29NO/c1-17-15-24(16-19-13-22(19)18-7-4-3-5-8-18)12-11-23(17,2)20-9-6-10-21(25)14-20/h3-10,14,17,19,22,25H,11-13,15-16H2,1-2H3/t17-,19-,22-,23+/m0/s1
  • InChiKey: ZBKMHZDNQWQSNM-MZGVDSNGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Mu opioid receptor Starlite/ChEMBL References
Cavia porcellus Kappa opioid receptor Starlite/ChEMBL References
Rattus norvegicus Delta opioid receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis thyrotropin releasing hormone receptor Delta opioid receptor   372 aa 330 aa 24.2 %
Schistosoma mansoni rhodopsin-like orphan GPCR Kappa opioid receptor   380 aa 379 aa 22.4 %
Onchocerca volvulus Delta opioid receptor   372 aa 316 aa 26.9 %
Onchocerca volvulus Phospholipase d-related homolog Kappa opioid receptor   380 aa 326 aa 20.9 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Delta opioid receptor   372 aa 315 aa 28.6 %
Schistosoma japonicum Rhodopsin, putative Mu opioid receptor   398 aa 328 aa 23.2 %
Onchocerca volvulus Kappa opioid receptor   380 aa 310 aa 24.2 %
Echinococcus granulosus allatostatin A receptor Delta opioid receptor   372 aa 302 aa 27.8 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Delta opioid receptor   372 aa 320 aa 25.6 %
Loa Loa (eye worm) neuropeptide F receptor Delta opioid receptor   372 aa 317 aa 23.3 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Kappa opioid receptor   380 aa 352 aa 20.2 %
Brugia malayi hypothetical protein Kappa opioid receptor   380 aa 319 aa 21.6 %
Echinococcus granulosus somatostatin receptor Kappa opioid receptor   380 aa 342 aa 19.6 %
Onchocerca volvulus Delta opioid receptor   372 aa 386 aa 22.8 %
Onchocerca volvulus Delta opioid receptor   372 aa 349 aa 22.1 %
Onchocerca volvulus Mitogen-activated protein kinase kinase kinase 8 homolog Kappa opioid receptor   380 aa 395 aa 20.3 %
Onchocerca volvulus Delta opioid receptor   372 aa 344 aa 22.1 %
Echinococcus multilocularis growth hormone secretagogue receptor type 1 Kappa opioid receptor   380 aa 306 aa 21.2 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Mu opioid receptor   398 aa 334 aa 23.1 %
Brugia malayi hypothetical protein Kappa opioid receptor   380 aa 320 aa 20.6 %
Brugia malayi ORL1-like opioid receptor Delta opioid receptor   372 aa 300 aa 24.7 %
Brugia malayi GnHR receptor homolog Delta opioid receptor   372 aa 313 aa 18.5 %
Onchocerca volvulus Programmed cell death protein 5 homolog Mu opioid receptor   398 aa 323 aa 24.1 %
Onchocerca volvulus Delta opioid receptor   372 aa 353 aa 21.0 %
Echinococcus granulosus thyrotropin releasing hormone receptor Delta opioid receptor   372 aa 330 aa 24.5 %
Onchocerca volvulus Phosphoinositide 3-kinase adapter subunit homolog Kappa opioid receptor   380 aa 323 aa 22.6 %
Echinococcus multilocularis allatostatin A receptor Delta opioid receptor   372 aa 302 aa 28.5 %
Schistosoma mansoni neuropeptide F-like receptor Mu opioid receptor   398 aa 335 aa 20.6 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Delta opioid receptor   372 aa 366 aa 22.7 %
Schistosoma mansoni peptide (allatostatin)-like receptor Delta opioid receptor   372 aa 353 aa 29.2 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Mu opioid receptor   398 aa 397 aa 22.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi PAB1-binding protein , putative 0.0105 0.0897 0.1915
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0045 0.0045
Echinococcus multilocularis G-protein coupled receptor, putative 0.0021 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Echinococcus granulosus chromobox protein 1 0.008 0.0641 0.0641
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0079 0.0632 0.1348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0411 0.1726
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0303 0.0303
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0252 0.2382 0.5082
Loa Loa (eye worm) hypothetical protein 0.0018 0.0019 0.0041
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0001 0.0001
Echinococcus multilocularis g-protein coupled receptor 0.0021 0.0045 0.0045
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0021 0.0045 0.0045
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0021 0.0045 0.0097
Brugia malayi CXXC zinc finger family protein 0.0028 0.012 0.0257
Echinococcus granulosus g-protein coupled receptor 0.0021 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0411 0.0595
Echinococcus granulosus cathepsin L cysteine protease 0.0136 0.121 0.121
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0045 0.0045
Echinococcus granulosus 7TM GPCR rhodopsin 0.0021 0.0045 0.0045
Plasmodium falciparum ataxin-2 like protein, putative 0.0105 0.0897 0.3667
Plasmodium falciparum serine repeat antigen 6 0.0057 0.0411 0.1593
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.031 0.1301
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0021 0.0045 0.0045
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0087 0.0716 0.3006
Echinococcus granulosus neuropeptide receptor 0.0021 0.0045 0.0045
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0087 0.0716 0.0716
Brugia malayi hypothetical protein 0.0068 0.052 0.111
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0045 0.0045
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0021 0.0045 0.0066
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0172 0.0366
Schistosoma mansoni cpg binding protein 0.0032 0.0155 0.0225
Brugia malayi Dopamine receptor 0.0021 0.0045 0.0097
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0045 0.0097
Plasmodium vivax serine-repeat antigen (SERA) 0.0057 0.0411 0.1593
Loa Loa (eye worm) hypothetical protein 0.0252 0.2382 0.5082
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0057 0.0411 0.1593
Schistosoma mansoni opsin-like receptor 0.0021 0.0045 0.0066
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0173 0.1583 0.3377
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Giardia lamblia Cysteine protease 0.0057 0.0411 0.2202
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0411 0.1726
Trichomonas vaginalis ferritin, putative 0.0017 0 0.0001
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0076 0.0161
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0127 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0057 0.0411 0.1726
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0057 0.0411 0.0877
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0057 0.0411 0.1593
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0045 0.0066
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0045 0.0066
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0453 0.0656
Loa Loa (eye worm) transcription factor SMAD2 0.0352 0.3394 0.7241
Brugia malayi Papain family cysteine protease containing protein 0.0136 0.121 0.2582
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0411 0.1726
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0479 0.4687 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0252 0.2382 1
Leishmania major hypothetical protein, conserved 0.0105 0.0897 0.3667
Entamoeba histolytica hypothetical protein 0.0221 0.2067 0.8678
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0087 0.0716 0.0716
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0038 0.0407
Schistosoma mansoni smad1 5 8 and 0.0024 0.0076 0.0109
Trypanosoma cruzi cysteine peptidase, putative 0.0252 0.2382 0.5082
Schistosoma mansoni amine GPCR 0.0021 0.0045 0.0066
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Loa Loa (eye worm) cysteine protease 0.0252 0.2382 0.5082
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0411 0.0595
Entamoeba histolytica cysteine protease, putative 0.0057 0.0411 0.1726
Echinococcus granulosus zinc finger protein 0.0024 0.008 0.008
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0029 0.0129 0.0542
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0057 0.0411 0.1593
Entamoeba histolytica cysteine protease, putative 0.0057 0.0411 0.1726
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0127
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0045 0.0066
Brugia malayi neuropeptide F receptor 0.0021 0.0045 0.0097
Echinococcus multilocularis Smad4 0.0024 0.0076 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Giardia lamblia Cysteine protease 0.0057 0.0411 0.2202
Echinococcus granulosus 7tm_1 domain containing protein 0.0021 0.0045 0.0045
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0188 0.1734 0.3699
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0057 0.0411 0.2202
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0127 0.5
Echinococcus granulosus somatostatin receptor 0.0021 0.0045 0.0045
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0241 0.0865
Giardia lamblia Cathepsin L precursor 0.0057 0.0411 0.2202
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0057 0.0411 0.0877
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0127 0.0533
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.121 0.5081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0411 0.1726
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0136 0.121 0.2582
Giardia lamblia GTOR 0.0087 0.0716 0.3999
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1298 0.1878
Loa Loa (eye worm) hypothetical protein 0.0173 0.1583 0.3377
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0476 0.0476
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.1368 0.1368
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0127
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0029 0.0129 0.0129
Schistosoma mansoni neuropeptide receptor 0.0021 0.0045 0.0066
Schistosoma mansoni adenoreceptor 0.0021 0.0045 0.0066
Toxoplasma gondii cathepsin B 0.0188 0.1734 0.7279
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0921 0.1332
Giardia lamblia Cathepsin B precursor 0.0188 0.1734 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.031 0.031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0045 0.0066
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.031 0.031
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0045 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0303 0.0438
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.049 0.2056
Onchocerca volvulus 0.0173 0.1583 0.6581
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0221 0.2067 0.2067
Brugia malayi G-protein coupled receptor 0.0021 0.0045 0.0097
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0087 0.0716 0.1036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Brugia malayi Papain family cysteine protease containing protein 0.0057 0.0411 0.0877
Onchocerca volvulus 0.0035 0.0188 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0129 0.0542
Plasmodium vivax vivapain-2 0.0252 0.2382 1
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0172 0.0366
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0045 0.0045
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.121 0.2582
Loa Loa (eye worm) hypothetical protein 0.0045 0.0286 0.061
Echinococcus granulosus orexin receptor type 2 0.0021 0.0045 0.0045
Echinococcus granulosus neuropeptide s receptor 0.0021 0.0045 0.0045
Brugia malayi Serotonin receptor 0.0021 0.0045 0.0097
Echinococcus granulosus Smad4 0.0024 0.0076 0.0076
Giardia lamblia Cathepsin B precursor 0.0057 0.0411 0.2202
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0045 0.0045
Onchocerca volvulus 0.0147 0.1321 0.546
Brugia malayi Bromodomain containing protein 0.0041 0.0248 0.0529
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Leishmania major cathepsin L-like protease 0.0252 0.2382 1
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0045 0.0045
Brugia malayi Bromodomain containing protein 0.0078 0.0626 0.1337
Echinococcus multilocularis GPCR, family 2 0.0033 0.0172 0.0172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0361 0.1514
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0921 0.3768
Schistosoma mansoni hypothetical protein 0.0182 0.1678 0.2427
Trichomonas vaginalis chromobox protein, putative 0.008 0.0641 0.2692
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Brugia malayi Serotonin receptor 0.0021 0.0045 0.0097
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0029 0.0129 0.0275
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0361 0.1514
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Giardia lamblia Cathepsin L precursor 0.0057 0.0411 0.2202
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Echinococcus multilocularis neuropeptide FF receptor 2 0.0021 0.0045 0.0045
Onchocerca volvulus 0.0252 0.2382 1
Brugia malayi Cathepsin L-like precursor 0.0252 0.2382 0.5082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0076 0.0161
Loa Loa (eye worm) hypothetical protein 0.0069 0.0531 0.1133
Schistosoma mansoni cathepsin S (C01 family) 0.0057 0.0411 0.0595
Leishmania major cathepsin L-like protease 0.0252 0.2382 1
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Schistosoma mansoni myosin xvIII 0.0021 0.0045 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0045 0.0066
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0045 0.0097
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0057 0.0411 0.1593
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0038 0.0158
Echinococcus multilocularis microtubule associated protein 2 0.0699 0.6913 0.6913
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0045 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0411 0.1726
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0038 0.0081
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Echinococcus granulosus peptide allatostatin:somatostatin 0.0021 0.0045 0.0045
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0117 0.0117
Loa Loa (eye worm) acetyltransferase 0.0152 0.1368 0.2919
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Brugia malayi MH1 domain containing protein 0.0024 0.0076 0.0161
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0021 0.0045 0.0066
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0045 0.0045
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0045 0.0045
Toxoplasma gondii target of rapamycin (TOR), putative 0.0065 0.049 0.2056
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0479 0.4687 0.6781
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0029 0.0129 0.0275
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1298 0.1878
Brugia malayi G protein-coupled receptor F59B2.13 0.0021 0.0045 0.0097
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0921 0.1965
Echinococcus granulosus neuropeptide receptor 0.0021 0.0045 0.0045
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0021 0.0045 0.0097
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0127 0.0381
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0038 0.0081
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Schistosoma mansoni fkbp-rapamycin associated protein 0.0016 0.00000001237 0.000000017895
Echinococcus multilocularis cathepsin L 0.0057 0.0411 0.0411
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0021 0.0045 0.0066
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0057 0.0411 0.2202
Echinococcus granulosus serotonin receptor 0.0021 0.0045 0.0045
Schistosoma mansoni zinc finger protein 0.0024 0.008 0.0115
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0087 0.0716 0.3006
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0127 0.0533
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0301 0.0301
Giardia lamblia Cathepsin L-like protease 0.0057 0.0411 0.2202
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0021 0.0045 0.0066
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0072 0.0104
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0903 0.1927
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0072 0.0072
Giardia lamblia Cathepsin B precursor 0.0057 0.0411 0.2202
Schistosoma mansoni cathepsin s 0.0079 0.0632 0.0914
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0411 0.0595
Loa Loa (eye worm) Smad1 0.0024 0.0076 0.0161
Plasmodium falciparum serine repeat antigen 1 0.0057 0.0411 0.1593
Echinococcus granulosus smad 0.0024 0.0076 0.0076
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0045 0.0097
Schistosoma mansoni bromodomain containing protein 0.0067 0.0511 0.0739
Loa Loa (eye worm) hypothetical protein 0.0035 0.0188 0.0401
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0286 0.103
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0001 0.0001
Brugia malayi Dopamine receptor protein 2 0.0021 0.0045 0.0097
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0188 0.0188
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0286 0.1201
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0001 0.0001
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0057 0.0411 0.1593
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0057 0.0411 0.1593
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0535 0.2247
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0057 0.0411 0.1726
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Echinococcus granulosus allatostatin A receptor 0.0021 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0047 0.0307 0.0655
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0076 0.0076
Plasmodium falciparum serine repeat antigen 2 0.0057 0.0411 0.1593
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0252 0.2382 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0057 0.0411 0.0595
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0045 0.0066
Loa Loa (eye worm) hypothetical protein 0.0106 0.0903 0.1927
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0001 0.0001
Echinococcus multilocularis dro:myosuppressin receptor 0.0021 0.0045 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.031 0.1301
Schistosoma mansoni histamine h1 receptor 0.0021 0.0045 0.0066
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0057 0.0411 0.1726
Echinococcus granulosus cathepsin l cysteine peptidase 0.0252 0.2382 0.2382
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0057 0.0411 0.1726
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0921 0.3867
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0087 0.0716 0.3006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0172 0.0172
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0252 0.2382 0.2382
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0045 0.0066
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0021 0.0045 0.0097
Brugia malayi cathepsin F-like cysteine proteinase 0.0079 0.0632 0.1348
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0646 0.6373 0.6373
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0057 0.0411 0.2202
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0411 0.1726
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0449 0.1883
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0021 0.0045 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0045 0.0066
Loa Loa (eye worm) hypothetical protein 0.0173 0.1583 0.3377
Trypanosoma cruzi cysteine peptidase, putative 0.0252 0.2382 0.5082
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0045 0.0045
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0127 0.0533
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0411 0.1726
Brugia malayi AKH receptor 0.0021 0.0045 0.0097
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0076 0.0109
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0057 0.0411 0.0877
Toxoplasma gondii cathepsin CPC1 0.0057 0.0411 0.1726
Trypanosoma brucei cysteine peptidase C (CPC) 0.0188 0.1734 0.7279
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Echinococcus granulosus tm gpcr rhodopsin 0.0646 0.6373 0.6373
Brugia malayi 6-phosphofructokinase 0.0107 0.0921 0.1965
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0252 0.2382 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0587 0.2464
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Brugia malayi cathepsin L-like cysteine proteinase 0.0057 0.0411 0.0877
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0021 0.0045 0.0097
Echinococcus granulosus geminin 0.0182 0.1678 0.1678
Echinococcus multilocularis cathepsin L cysteine protease 0.0252 0.2382 0.2382
Giardia lamblia Cathepsin L precursor 0.0057 0.0411 0.2202
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0021 0.0045 0.0097
Schistosoma mansoni biogenic amine receptor 0.0021 0.0045 0.0066
Brugia malayi Papain family cysteine protease containing protein 0.0057 0.0411 0.0877
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0921 0.3867
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0045 0.0045
Brugia malayi phosphofructokinase 0.0107 0.0921 0.1965
Brugia malayi fibroinase precursor 0.0057 0.0411 0.0877
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.121 0.5081
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.1302 0.1302
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0045 0.0066
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0076 0.0076
Echinococcus granulosus cathepsin b 0.0479 0.4687 0.4687
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0057 0.0411 0.0877
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0029 0.0129 0.0129
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.1368 0.2919
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0069 0.0536 0.2126
Giardia lamblia Encystation-specific protease 0.0057 0.0411 0.2202
Leishmania major phosphatidylinositol 3-kinase, putative 0.0029 0.0129 0.039
Brugia malayi cathepsin L-like precursor 0.0173 0.1583 0.3377
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0188 0.0188
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0041 0.0251 0.1052
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0045 0.0045
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0045 0.0045
Onchocerca volvulus Cathepsin L homolog 0.0252 0.2382 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0632 0.1348
Trypanosoma cruzi PAB1-binding protein , putative 0.0105 0.0897 0.1915
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0057 0.0411 0.2202
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0921 0.0921
Brugia malayi MH2 domain containing protein 0.0024 0.0076 0.0161
Schistosoma mansoni biogenic amine receptor 0.0021 0.0045 0.0066
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0021 0.0045 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0286 0.1201
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0252 0.2382 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0045 0.0066
Plasmodium vivax SET domain protein, putative 0.003 0.0135 0.0413
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0087 0.0716 0.2893
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.1298 0.1298
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0038 0.0081
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0127 0.0526
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.3924 0.3924
Schistosoma mansoni hypothetical protein 0.0047 0.031 0.0449
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0079 0.0632 0.1348
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.0716 0.3006
Echinococcus granulosus G protein coupled receptor 139 0.0021 0.0045 0.0045
Leishmania major cysteine peptidase A (CPA) 0.0252 0.2382 1
Loa Loa (eye worm) heterochromatin protein 1 0.008 0.0641 0.1368
Giardia lamblia Hypothetical protein 0.0057 0.0411 0.2202
Loa Loa (eye worm) hypothetical protein 0.0057 0.0411 0.0877
Echinococcus multilocularis cathepsin L 0.0136 0.121 0.121
Brugia malayi Pre-SET motif family protein 0.003 0.0135 0.0287
Loa Loa (eye worm) hypothetical protein 0.0079 0.0632 0.1348
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0921 0.1965
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0038 0.0158
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.1298 0.1298
Leishmania major cathepsin L-like protease 0.0252 0.2382 1
Entamoeba histolytica cysteine protease, putative 0.0057 0.0411 0.1726
Schistosoma mansoni hypothetical protein 0.002 0.0037 0.0053
Echinococcus multilocularis geminin 0.0182 0.1678 0.1678
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0404 0.3924 0.5677
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0045 0.0045
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0045 0.0045
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Schistosoma mansoni hypothetical protein 0.0021 0.0045 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0221 0.2067 0.2067
Schistosoma mansoni hypothetical protein 0.0033 0.0172 0.0248
Plasmodium vivax vivapain-2 0.0252 0.2382 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0038 0.0407
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0241 0.101
Brugia malayi cathepsin Z-like cysteine proteinase 0.0057 0.0411 0.0877
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Brugia malayi 6-phosphofructokinase 0.0107 0.0921 0.1965
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0921 0.3867
Echinococcus multilocularis tumor protein p63 0.1004 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0154 0.0646
Giardia lamblia Cathepsin L-like protease 0.0057 0.0411 0.2202
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0929 0.924 0.924
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.007 0.0293
Trypanosoma cruzi cruzipain precursor, putative 0.0079 0.0632 0.1348
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0921 1
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0127 0.1375
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.1298 0.277
Echinococcus multilocularis sex peptide receptor 0.0021 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0057 0.0411 0.1726
Echinococcus multilocularis allatostatin A receptor 0.0021 0.0045 0.0045
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0 0.0001
Brugia malayi ORL1-like opioid receptor 0.0021 0.0045 0.0097
Toxoplasma gondii preprocathepsin c precursor, putative 0.0057 0.0411 0.1726
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0241 0.1196
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0903 0.1927
Brugia malayi Cathepsin L-like cysteine proteinase 0.0173 0.1583 0.3377
Echinococcus granulosus cathepsin L 0.0057 0.0411 0.0411
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0127
Schistosoma mansoni neuropeptide receptor 0.0021 0.0045 0.0066
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0188 0.1734 0.7235
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0087 0.0716 0.3006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.1368 0.1979
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0921 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0921 1
Echinococcus multilocularis orexin receptor type 2 0.0021 0.0045 0.0045
Loa Loa (eye worm) phosphatidylinositol 3 0.0087 0.0716 0.1528
Brugia malayi MH1 domain containing protein 0.0024 0.0076 0.0161
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0087 0.0716 0.1528
Plasmodium falciparum serine repeat antigen 4 0.0057 0.0411 0.1593
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Schistosoma mansoni cathepsin C 0.0057 0.0411 0.0595
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0021 0.0045 0.0045
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0921 0.1965
Entamoeba histolytica hypothetical protein 0.0221 0.2067 0.8678
Echinococcus multilocularis G protein coupled receptor 139 0.0021 0.0045 0.0045
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0188 0.1734 0.2508
Brugia malayi chromobox protein homolog 3 0.0045 0.0286 0.061
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0479 0.4687 0.6781
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0057 0.0411 0.1593
Onchocerca volvulus Cathepsin L homolog 0.0252 0.2382 1
Echinococcus multilocularis cpg binding protein 0.0032 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0303 0.0303
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0411 0.0595
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Entamoeba histolytica hypothetical protein 0.0221 0.2067 0.8678
Schistosoma mansoni amine GPCR 0.0021 0.0045 0.0066
Echinococcus multilocularis smad 0.0024 0.0076 0.0076
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0127 0.0533
Echinococcus granulosus g protein coupled receptor 0.0021 0.0045 0.0045
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0087 0.0716 0.1528
Entamoeba histolytica cysteine protease, putative 0.0057 0.0411 0.1726
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0029 0.0129 0.0275
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.121 0.5081
Brugia malayi Heterochromatin protein 1 0.008 0.0641 0.1368
Brugia malayi cathepsin Z-like cysteine proteinase 0.0057 0.0411 0.0877
Schistosoma mansoni hypothetical protein 0.0072 0.0565 0.0817
Schistosoma mansoni cpg binding protein 0.0032 0.0155 0.0225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0252 0.2382 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.003 0.0127
Onchocerca volvulus 0.0252 0.2382 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.0716 0.3006
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.121 0.5081
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0021 0.0045 0.0066
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0045 0.0045
Echinococcus granulosus cathepsin l1 0.0252 0.2382 0.2382
Leishmania major cathepsin L-like protease 0.0252 0.2382 1
Schistosoma mansoni neuropeptide receptor 0.0021 0.0045 0.0066
Onchocerca volvulus 0.0252 0.2382 1
Onchocerca volvulus Cathepsin F homolog 0.0252 0.2382 1
Brugia malayi Dopamine receptor protein 1 0.0021 0.0045 0.0097
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0252 0.2382 1
Brugia malayi larval opioid receptor 0.0021 0.0045 0.0097
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0038 0.0081
Trypanosoma cruzi target of rapamycin kinase 3 0.0069 0.0536 0.1144
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0029 0.0129 0.039
Echinococcus multilocularis chromobox protein 1 0.008 0.0641 0.0641
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0301 0.1263
Plasmodium vivax unspecified product 0.0136 0.121 0.5001
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0411 0.1726
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0057 0.0411 0.1726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0136 0.121 0.5081
Giardia lamblia Cathepsin L precursor 0.0057 0.0411 0.2202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0535 0.2247
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0021 0.0045 0.0097
Leishmania major cathepsin L-like protease 0.0252 0.2382 1
Giardia lamblia Cysteine protease 0.0057 0.0411 0.2202
Giardia lamblia Cathepsin B precursor 0.0188 0.1734 1
Brugia malayi Cathepsin L-like precursor 0.0252 0.2382 0.5082
Brugia malayi neuropeptide F receptor 0.0021 0.0045 0.0097
Schistosoma mansoni hypothetical protein 0.0033 0.0172 0.0248
Schistosoma mansoni growth hormone secretagogue receptor 0.0021 0.0045 0.0066
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0127 0.0533
Trypanosoma cruzi cysteine proteinase, putative 0.0136 0.121 0.2582
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0045 0.0097
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0127
Giardia lamblia Cathepsin B precursor 0.0057 0.0411 0.2202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.049 0.2056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0129 0.0542
Plasmodium falciparum ataxin-2 like protein, putative 0.0105 0.0897 0.3667
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0127 0.0533
Echinococcus granulosus neuropeptide FF receptor 2 0.0021 0.0045 0.0045
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0057 0.0411 0.1593
Schistosoma mansoni cathepsin F (C01 family) 0.0252 0.2382 0.3446
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0045 0.0045
Schistosoma mansoni microtubule-associated protein tau 0.0699 0.6913 1
Echinococcus granulosus g protein coupled receptor 0.0021 0.0045 0.0045
Entamoeba histolytica cysteine protease, putative 0.0057 0.0411 0.1726
Echinococcus granulosus alpha 1A adrenergic receptor 0.0021 0.0045 0.0045
Brugia malayi PHD-finger family protein 0.003 0.0132 0.0282
Giardia lamblia Cathepsin B precursor 0.0057 0.0411 0.2202
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Plasmodium falciparum serine repeat antigen 9 0.0057 0.0411 0.1593
Loa Loa (eye worm) hypothetical protein 0.0057 0.0411 0.0877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0535 0.2247
Loa Loa (eye worm) hypothetical protein 0.0057 0.0411 0.0877
Echinococcus multilocularis somatostatin receptor 0.0021 0.0045 0.0045
Schistosoma mansoni cathepsin F (C01 family) 0.0173 0.1583 0.229
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0411 0.0877
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0087 0.0716 0.1528
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0038 0.0158
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0057 0.0411 0.1593
Plasmodium vivax serine-repeat antigen (SERA) 0.0057 0.0411 0.1593
Giardia lamblia Cathepsin L precursor 0.0057 0.0411 0.2202
Onchocerca volvulus 0.0252 0.2382 1
Schistosoma mansoni opsin-like receptor 0.0021 0.0045 0.0066
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0076 0.0076
Echinococcus multilocularis cysteine protease 0.0252 0.2382 0.2382
Schistosoma mansoni ap endonuclease 0.002 0.0038 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0021 0.0045 0.0066
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0029 0.0129 0.0542
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0411 0.0595
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Brugia malayi Tachykinin-like peptides receptor 99D 0.0021 0.0045 0.0097
Brugia malayi cathepsin F-like cysteine proteinase 0.0057 0.0411 0.0877
Echinococcus granulosus sex peptide receptor 0.0021 0.0045 0.0045
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0045 0.0045
Brugia malayi Cathepsin L-like precursor 0.0173 0.1583 0.3377
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0021 0.0045 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0043 0.0272 0.058
Plasmodium vivax vivapain-3 0.0136 0.121 0.5001
Plasmodium vivax unspecified product 0.0079 0.0632 0.2535
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0045 0.0045
Trichomonas vaginalis set domain proteins, putative 0.0232 0.2183 0.9164
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Brugia malayi cathepsin L precursor 0.0057 0.0411 0.0877
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0479 0.4687 0.6781
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0021 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0252 0.2382 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0021 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0057 0.0411 0.1726
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0406 0.1705
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0036 0.02 0.0839
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0127 0.0381
Brugia malayi Papain family cysteine protease containing protein 0.0057 0.0411 0.0877
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Trypanosoma cruzi cysteine protease, putative 0.0136 0.121 0.2582
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Brugia malayi RE15519p 0.0021 0.0045 0.0097
Schistosoma mansoni ap endonuclease 0.002 0.0038 0.0055
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0476 0.0476
Echinococcus multilocularis serotonin receptor 0.0021 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0033 0.0172 0.0366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.049 0.2056
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Toxoplasma gondii cathepsin CPL 0.0252 0.2382 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0309 0.1298
Brugia malayi Cathepsin L-like precursor 0.0173 0.1583 0.3377
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0411 0.1726
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0129 0.0542
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.1298 0.277
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0087 0.0716 0.2893
Trypanosoma cruzi cysteine peptidase, putative 0.0252 0.2382 0.5082
Onchocerca volvulus 0.0028 0.012 0.0321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.049 0.2056
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0301 0.1123
Brugia malayi G protein-coupled receptor 0.0021 0.0045 0.0097
Toxoplasma gondii cathepsin CPC2 0.0057 0.0411 0.1726
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Toxoplasma gondii LsmAD domain-containing protein 0.0105 0.0897 0.3768
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Loa Loa (eye worm) MH2 domain-containing protein 0.0352 0.3394 0.7241
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0361 0.1514
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0045 0.0045
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0001 0.0002
Echinococcus granulosus cathepsin b 0.0479 0.4687 0.4687
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Schistosoma mansoni transcription factor LCR-F1 0.0221 0.2067 0.299
Onchocerca volvulus 0.0252 0.2382 1
Brugia malayi G-protein coupled receptor 0.0021 0.0045 0.0097
Echinococcus granulosus chromobox protein 1 0.008 0.0641 0.0641
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0252 0.2382 1
Echinococcus granulosus dnaJ subfamily B 0.0404 0.3924 0.3924
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.049 0.2056
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.032 0.1177
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0057 0.0411 0.0595
Loa Loa (eye worm) cathepsin B 0.0188 0.1734 0.3699
Plasmodium vivax ataxin-2 like protein, putative 0.0105 0.0897 0.3667
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0038 0.0407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.049 0.2056
Brugia malayi sulfakinin receptor protein 0.0021 0.0045 0.0097
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0045 0.0045
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0038 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0127 0.0533
Schistosoma mansoni smad1 5 8 and 0.0024 0.0076 0.0109
Echinococcus granulosus microtubule associated protein 2 0.0699 0.6913 0.6913
Trypanosoma brucei PAB1-binding protein , putative 0.0105 0.0897 0.3768
Giardia lamblia Hypothetical protein 0.0057 0.0411 0.2202
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0057 0.0411 0.1593
Echinococcus granulosus GPCR family 2 0.0033 0.0172 0.0172
Plasmodium falciparum serine repeat antigen 3 0.0057 0.0411 0.1593
Onchocerca volvulus 0.0043 0.0267 0.0948
Brugia malayi putative neuropeptide receptor NPR1 0.0021 0.0045 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.031 0.1301
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Brugia malayi follicle stimulating hormone receptor 0.0021 0.0045 0.0097
Schistosoma mansoni hypothetical protein 0.0021 0.0045 0.0066
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0021 0.0045 0.0097
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0921 0.3867
Onchocerca volvulus 0.0232 0.2183 0.9148
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0252 0.2382 0.2382
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0565 0.1205
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0018 0.0019 0.008
Schistosoma mansoni neuropeptide receptor 0.0021 0.0045 0.0066
Echinococcus granulosus cathepsin L cysteine proteinase 0.0252 0.2382 0.2382
Trichomonas vaginalis chromobox protein, putative 0.0048 0.032 0.1345
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0057 0.0411 0.1593
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0045 0.0066
Loa Loa (eye worm) TYRA-2 protein 0.0021 0.0045 0.0097
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0057 0.0411 0.1593
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0252 0.2382 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0044 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0 0.0001
Schistosoma mansoni biogenic amine receptor 0.0021 0.0045 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0252 0.2382 0.5082
Plasmodium falciparum serine repeat antigen 5 0.0057 0.0411 0.1593
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0057 0.0411 0.1593
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0921 0.3867
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0301 0.1263
Echinococcus granulosus cathepsin L 0.0136 0.121 0.121
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0021 0.0045 0.0066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0252 0.2382 1
Schistosoma mansoni hypothetical protein 0.0221 0.2067 0.299
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0057 0.0411 0.0595
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0021 0.0045 0.0045
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0136 0.121 0.1751
Brugia malayi CHD4 protein 0.0017 0.0001 0.0001
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0038 0.0158
Loa Loa (eye worm) melatonin receptor type 1A 0.0021 0.0045 0.0097
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1898 0.405
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Echinococcus granulosus cathepsin l1 0.0173 0.1583 0.1583
Schistosoma mansoni neuropeptide f receptor 76f 0.0021 0.0045 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Schistosoma mansoni amine GPCR 0.0021 0.0045 0.0066
Schistosoma mansoni cellular tumor antigen P53 0.0147 0.1321 0.1911
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0045 0.0045
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.012 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0129 0.0542
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0045 0.0066
Schistosoma mansoni hypothetical protein 0.0182 0.1678 0.2427
Brugia malayi putative neuropeptide receptor 0.0021 0.0045 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0535 0.2247
Echinococcus multilocularis cathepsin b 0.0479 0.4687 0.4687
Entamoeba histolytica cysteine proteinase 2 0.0136 0.121 0.5081
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0921 0.3867
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0136 0.121 0.1751
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0057 0.0411 0.1726
Schistosoma mansoni amine GPCR 0.0021 0.0045 0.0066
Giardia lamblia Cysteine protease 0.0057 0.0411 0.2202
Brugia malayi MH2 domain containing protein 0.0024 0.0076 0.0161
Loa Loa (eye worm) ctsf protein 0.0252 0.2382 0.5082
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0301 0.1263
Onchocerca volvulus 0.0252 0.2382 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0355 0.1492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0355 0.1492
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0021 0.0045 0.0097
Schistosoma mansoni Smad4 0.0024 0.0076 0.0109
Schistosoma mansoni smad 0.0024 0.0076 0.0109
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0136 0.121 0.1751
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Giardia lamblia Cathepsin L precursor 0.0057 0.0411 0.2202
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0252 0.2382 1
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0173 0.1583 0.3377
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0135 0.0195
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0021 0.0045 0.0097
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.1298 0.1298
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0045 0.0066
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0029 0.0129 0.0187
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0921 0.1965
Schistosoma mansoni opsin-like receptor 0.0021 0.0045 0.0066
Brugia malayi GnHR receptor homolog 0.0021 0.0045 0.0097
Brugia malayi hypothetical protein 0.0105 0.0897 0.1915
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0135 0.0135
Brugia malayi MH2 domain containing protein 0.0352 0.3394 0.7241
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0038 0.0038
Schistosoma mansoni cpg binding protein 0.0028 0.012 0.0174
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Loa Loa (eye worm) hypothetical protein 0.0479 0.4687 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0029 0.0129 0.0275
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0172 0.0172
Giardia lamblia Cathepsin B precursor 0.0057 0.0411 0.2202
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0127 0.0533
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0903 0.1927
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0535 0.2247
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0188 0.1734 0.7279
Onchocerca volvulus 0.0252 0.2382 1
Schistosoma mansoni chromobox protein 0.008 0.0641 0.0928
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0154 0.0646
Echinococcus multilocularis cathepsin b 0.0479 0.4687 0.4687
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0045 0.0045
Entamoeba histolytica cysteine protease, putative 0.0057 0.0411 0.1726
Brugia malayi hypothetical protein 0.0221 0.2067 0.441
Entamoeba histolytica cysteine protease, putative 0.0252 0.2382 1
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0001 0.0001
Echinococcus granulosus cpg binding protein 0.0032 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Entamoeba histolytica cysteine proteinase, putative 0.0173 0.1583 0.6646
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0037 0.0078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0252 0.2382 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1298 0.1878
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0252 0.2382 1
Entamoeba histolytica cysteine proteinase, putative 0.0252 0.2382 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.0716 0.3006
Loa Loa (eye worm) hypothetical protein 0.0057 0.0411 0.0877
Loa Loa (eye worm) fibroinase 0.0252 0.2382 0.5082
Entamoeba histolytica cysteine proteinase 1, putative 0.0136 0.121 0.5081
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0172 0.0366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Trypanosoma cruzi cysteine peptidase, putative 0.0252 0.2382 0.5082
Brugia malayi Cathepsin L-like precursor 0.0079 0.0632 0.1348
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0479 0.4687 0.6781
Loa Loa (eye worm) hypothetical protein 0.0057 0.0411 0.0877
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0135 0.0565
Loa Loa (eye worm) hypothetical protein 0.0057 0.0411 0.0877
Brugia malayi cathepsin B-like cysteine proteinase 0.0479 0.4687 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0136 0.121 0.5001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0129 0.0542
Echinococcus granulosus hypothetical protein 0.0021 0.0045 0.0045
Brugia malayi Cathepsin L-like precursor 0.0252 0.2382 0.5082
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.031 0.1301
Echinococcus multilocularis neuropeptide s receptor 0.0021 0.0045 0.0045
Schistosoma mansoni cathepsin B (C01 family) 0.0057 0.0411 0.0595
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0045 0.0045
Giardia lamblia Cathepsin B precursor 0.0188 0.1734 1
Schistosoma mansoni hypothetical protein 0.0033 0.0172 0.0248
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0045 0.0045
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.003 0.0127
Brugia malayi Melatonin receptor type 1A 0.0021 0.0045 0.0097
Echinococcus granulosus neuropeptide receptor A26 0.0021 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0252 0.2382 1
Toxoplasma gondii exonuclease III APE 0.002 0.0038 0.0158
Echinococcus multilocularis cysteine protease 0.0252 0.2382 0.2382
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0921 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0045 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0425 0.1785
Echinococcus granulosus tachykinin peptides receptor 99D 0.0021 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0072 0.0565 0.1205
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0021 0.0045 0.0097
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0921 0.3867
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0173 0.1583 0.6646
Trypanosoma cruzi cysteine proteinase, putative 0.0136 0.121 0.2582
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0057 0.0411 0.1726
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0301 0.1263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.049 0.2056
Entamoeba histolytica cysteine protease, putative 0.0136 0.121 0.5081
Brugia malayi Cathepsin L-like precursor 0.0252 0.2382 0.5082
Brugia malayi Papain family cysteine protease containing protein 0.0252 0.2382 0.5082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0411 0.1726
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0127 0.0533
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0127 0.0533
Onchocerca volvulus 0.0057 0.0411 0.1566
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Leishmania major cathepsin L-like protease 0.0252 0.2382 1
Schistosoma mansoni amine GPCR 0.0021 0.0045 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Brugia malayi Smad1 0.0024 0.0076 0.0161
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0127
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0057 0.0411 0.0595
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0046 0.0303 0.0646
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Schistosoma mansoni hypothetical protein 0.0021 0.0045 0.0066
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0001 0.0001
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0021 0.0045 0.0045
Brugia malayi Papain family cysteine protease containing protein 0.0136 0.121 0.2582
Brugia malayi Pre-SET motif family protein 0.0204 0.1898 0.405
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0173 0.1583 0.6646
Schistosoma mansoni chromobox protein 0.008 0.0641 0.0928
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0057 0.0411 0.1726
Schistosoma mansoni smad1 5 8 and 0.0024 0.0076 0.0109
Trichomonas vaginalis chromobox protein, putative 0.008 0.0641 0.2692
Entamoeba histolytica hypothetical protein 0.0057 0.0411 0.1726
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0267 0.0386
Echinococcus granulosus dro:myosuppressin receptor 0.0021 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0147 0.1321 0.2819
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Schistosoma mansoni hypothetical protein 0.0021 0.0045 0.0066
Trichomonas vaginalis chromobox protein, putative 0.0048 0.032 0.1345
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0172 0.0172
Onchocerca volvulus Cathepsin L homolog 0.0057 0.0411 0.1566
Schistosoma mansoni alpha-1 adrenergic receptor 0.0021 0.0045 0.0066
Plasmodium falciparum serine repeat antigen 8 0.0057 0.0411 0.1593
Loa Loa (eye worm) hypothetical protein 0.0037 0.0212 0.0451
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.1298 0.1298
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0045 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0309 0.1298
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.121 0.5081
Plasmodium vivax unspecified product 0.0057 0.0411 0.1593
Trypanosoma cruzi cruzipain precursor, putative 0.0252 0.2382 0.5082
Leishmania major cathepsin L-like protease 0.0252 0.2382 1
Echinococcus granulosus g protein coupled receptor 0.0021 0.0045 0.0045
Plasmodium vivax vivapain-1 0.0136 0.121 0.5001
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0172 0.0172
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0127 0.0381
Loa Loa (eye worm) hypothetical protein 0.0079 0.0632 0.1348
Schistosoma mansoni hypothetical protein 0.0033 0.0172 0.0248
Echinococcus multilocularis zinc finger protein 0.0024 0.008 0.008
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0021 0.0045 0.0045
Brugia malayi Cathepsin L-like precursor 0.0252 0.2382 0.5082
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0021 0.0045 0.0066
Entamoeba histolytica cysteine proteinase, putative 0.0252 0.2382 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0303 0.0438
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0921 0.3867
Leishmania major cathepsin L-like protease 0.0252 0.2382 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0411 0.0877
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0921 0.1332
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0411 0.1726
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0097
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0072 0.0072
Entamoeba histolytica hypothetical protein 0.0221 0.2067 0.8678
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0632 0.1348
Plasmodium falciparum serine repeat antigen 7 0.0057 0.0411 0.1593
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0921 0.0921
Echinococcus granulosus fmrfamide receptor 0.0021 0.0045 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0309 0.1298
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0252 0.2382 1
Echinococcus granulosus cysteine protease 0.0136 0.121 0.121
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0019 0.008
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0069 0.0536 0.225
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0127 0.0381
Echinococcus multilocularis neuropeptide receptor A26 0.0021 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0105 0.0897 0.1915
Brugia malayi Cathepsin L-like precursor 0.0252 0.2382 0.5082
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0127 0.0533
Brugia malayi hypothetical protein 0.0021 0.0045 0.0097
Echinococcus multilocularis cathepsin L cysteine protease 0.0252 0.2382 0.2382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0136 0.121 0.5081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0252 0.2382 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0045 0.0045
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.121 0.5081
Echinococcus multilocularis chromobox protein 1 0.008 0.0641 0.0641
Schistosoma mansoni cathepsin F (C01 family) 0.0252 0.2382 0.3446
Echinococcus multilocularis serotonin receptor 0.0021 0.0045 0.0045
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0045 0.0045
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0045 0.0066

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.75 nM Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of rat brain membranes ChEMBL. 9599247
Ki (binding) = 81.8 nM Inhibition of [3H]U69,593 binding to Opioid receptor kappa 1 of guinea pig membranes ChEMBL. 9599247
Ki (binding) = 709 nM Inhibition of [3H]-DADLE binding to Opioid receptor delta 1 of rat brain membranes ChEMBL. 9599247

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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