Detailed information for compound 950705

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 544.65 | Formula: C25H31F3N2O4S2
  • H donors: 0 H acceptors: 4 LogP: 4.63 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(CN(S(=O)(=O)c1ccc(cc1)C=C1CCN(CC1)S(=O)(=O)C)Cc1ccccc1C(F)(F)F)C
  • InChi: 1S/C25H31F3N2O4S2/c1-19(2)17-30(18-22-6-4-5-7-24(22)25(26,27)28)36(33,34)23-10-8-20(9-11-23)16-21-12-14-29(15-13-21)35(3,31)32/h4-11,16,19H,12-15,17-18H2,1-3H3
  • InChiKey: FZKHRGDBHXKBBU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAR-related orphan receptor C Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi jmjC domain containing protein 0.0013 0.0005 0.0006
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0083 0.0147
Echinococcus multilocularis Niemann Pick C1 protein 0.0135 0.1604 0.1604
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.003 0.0231 0.0298
Schistosoma mansoni hypothetical protein 0.0236 0.2909 0.3751
Schistosoma mansoni jumonji domain containing protein 0.0013 0.0005 0.0006
Brugia malayi jmjC domain containing protein 0.0047 0.0454 0.0585
Onchocerca volvulus 0.0031 0.0251 0.0324
Echinococcus granulosus GTP binding nuclear protein Ran 0.0034 0.0279 0.036
Trichomonas vaginalis esterase, putative 0.003 0.0231 0.0697
Schistosoma mansoni lipoxygenase 0.0017 0.0066 0.0085
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0019 0.0083 0.0136
Brugia malayi Animal haem peroxidase family protein 0.0608 0.7755 1
Brugia malayi Bromodomain containing protein 0.0133 0.1566 0.2019
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0371 0.0478
Schistosoma mansoni hypothetical protein 0.0039 0.0351 0.0453
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0075 0.0861
Trypanosoma brucei importin beta-1 subunit, putative 0.0046 0.0436 1
Entamoeba histolytica hypothetical protein 0.0066 0.0697 0.3884
Loa Loa (eye worm) hypothetical protein 0.0181 0.2201 0.2838
Echinococcus granulosus lipoxygenase domain containing protein 0.0017 0.0066 0.0085
Loa Loa (eye worm) hypothetical protein 0.0608 0.7755 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0034 0.0279 0.0279
Brugia malayi T-complex protein 1, beta subunit 0.0019 0.0093 0.012
Giardia lamblia Histone acetyltransferase GCN5 0.0035 0.0301 1
Onchocerca volvulus 0.0019 0.0083 0.0107
Onchocerca volvulus 0.0608 0.7755 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0034 0.0279 0.6091
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0231 0.0697
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0034 0.0279 0.036
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0031 0.0251 0.0787
Giardia lamblia Sentrin specific protease, putative 0.0031 0.0251 0.7789
Echinococcus multilocularis beta LACTamase domain containing family member 0.003 0.0231 0.0231
Trichomonas vaginalis ran, putative 0.0034 0.0279 0.0913
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0019 0.0083 0.1343
Loa Loa (eye worm) hypothetical protein 0.0063 0.0663 0.0855
Trichomonas vaginalis antibiotic synthetase, putative 0.0019 0.0083 0.0036
Giardia lamblia TCP-1 chaperonin subunit beta 0.0019 0.0093 0.083
Brugia malayi Animal haem peroxidase family protein 0.0608 0.7755 1
Plasmodium falciparum acyl-CoA synthetase 0.0047 0.0456 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0034 0.0279 0.9038
Echinococcus granulosus Niemann Pick C1 protein 0.0135 0.1604 0.2068
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0045 0.0422 0.1635
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0167 0.202 0.2605
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0121 0.1411 0.182
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0538 0.0694
Plasmodium vivax hypothetical protein, conserved 0.003 0.0231 0.5017
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0054 0.0538 0.0538
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.1075 0.1386
Onchocerca volvulus 0.019 0.2316 0.2987
Echinococcus multilocularis geminin 0.0451 0.5708 0.5708
Plasmodium vivax sentrin-specific protease 2, putative 0.0031 0.0251 0.5463
Schistosoma mansoni patched 1 0.0041 0.0371 0.0478
Brugia malayi Importin beta-1 subunit 0.0046 0.0436 0.0563
Loa Loa (eye worm) animal heme peroxidase 0.0608 0.7755 1
Echinococcus granulosus lysine specific demethylase 6a 0.0013 0.0005 0.0006
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0019 0.0093 0.1969
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0371 0.132
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0395 0.1431
Brugia malayi hypothetical protein 0.0017 0.0066 0.0085
Schistosoma mansoni cpg binding protein 0.0031 0.024 0.0309
Schistosoma mansoni sex comb on midleg homolog 0.0038 0.0338 0.0436
Brugia malayi RNA recognition motif domain containing protein 0.0167 0.202 0.2605
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0045 0.0422 0.1635
Mycobacterium ulcerans acyl-CoA synthetase 0.0063 0.0663 1
Brugia malayi Flap endonuclease-1 0.0024 0.0148 0.019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0053 0.0533 0.7784
Echinococcus granulosus zinc finger protein 0.0038 0.0337 0.0434
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0096 0.1094 0.141
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0024 0.016 0.2668
Schistosoma mansoni hypothetical protein 0.0039 0.0351 0.0453
Toxoplasma gondii aldehyde dehydrogenase 0.0053 0.0533 0.9096
Brugia malayi jmjC domain containing protein 0.0013 0.0005 0.0006
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0031 0.0251 0.0324
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0167 0.2016 0.26
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0019 0.0083 0.1184
Schistosoma mansoni rab6-interacting 0.0017 0.0066 0.0085
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0585 1
Mycobacterium ulcerans esterase/lipase LipP 0.003 0.0231 0.2654
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0024 0.0148 0.2464
Loa Loa (eye worm) hypothetical protein 0.0047 0.0456 0.0587
Leishmania major acetyl-CoA synthetase, putative 0.0019 0.0083 0.1184
Schistosoma mansoni flap endonuclease-1 0.0021 0.0118 0.0152
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0167 0.202 0.2605
Echinococcus granulosus lipoxygenase domain containing protein 0.0017 0.0066 0.0085
Loa Loa (eye worm) hypothetical protein 0.003 0.0231 0.0298
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0057 0.0588 0.0588
Mycobacterium ulcerans hypothetical protein 0.003 0.0231 0.2654
Loa Loa (eye worm) hypothetical protein 0.003 0.0231 0.0298
Echinococcus granulosus RUN 0.0017 0.0066 0.0085
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0053 0.0533 0.8019
Schistosoma mansoni polycystin 1-related 0.0017 0.0066 0.0085
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0019 0.0093 0.012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0121 0.1411 0.182
Echinococcus multilocularis phd:f box containing protein 0.0013 0.0005 0.0005
Trichomonas vaginalis flap endonuclease-1, putative 0.0024 0.0148 0.0326
Brugia malayi jmjC domain containing protein 0.0013 0.0005 0.0006
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0057 0.0588 0.0758
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0024 0.0148 0.1761
Mycobacterium ulcerans beta-lactamase 0.003 0.0231 0.2654
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0038 0.0338 0.0436
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0191 0.233 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0121 0.1411 0.182
Brugia malayi Calcitonin receptor-like protein seb-1 0.0181 0.2201 0.2838
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0075 0.5
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0029 0.022 0.022
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0083 0.0107
Echinococcus multilocularis flap endonuclease 1 0.0024 0.0148 0.0148
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0075 0.0817 0.1054
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0019 0.0093 0.0117
Schistosoma mansoni jumonji/arid domain-containing protein 0.0052 0.0515 0.0665
Schistosoma mansoni zinc finger protein 0.0026 0.0181 0.0233
Loa Loa (eye worm) hypothetical protein 0.0038 0.0338 0.0436
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0019 0.0093 0.0084
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0031 0.0251 0.0324
Loa Loa (eye worm) latrophilin receptor protein 2 0.0057 0.0588 0.0758
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0121 0.1411 0.1411
Loa Loa (eye worm) hypothetical protein 0.003 0.0231 0.0298
Schistosoma mansoni tar DNA-binding protein 0.0167 0.202 0.2605
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0075 0.0861
Schistosoma mansoni peroxidasin 0.0608 0.7755 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0052 0.0515 0.0665
Brugia malayi Animal haem peroxidase family protein 0.0608 0.7755 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0063 0.0663 0.3672
Plasmodium vivax SET domain protein, putative 0.0024 0.016 0.3436
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0083 0.0136
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0063 0.0663 0.2693
Toxoplasma gondii ABC1 family protein 0.003 0.0231 0.3895
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0075 0.0096
Loa Loa (eye worm) hypothetical protein 0.0073 0.0787 0.1015
Schistosoma mansoni hypothetical protein 0.0057 0.0588 0.0758
Trypanosoma brucei ISWI complex protein 0.0026 0.0181 0.4077
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0066 0.0697 0.0899
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0053 0.0533 0.0687
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0019 0.0083 0.0136
Echinococcus granulosus JmjC domain containing protein 4 0.0013 0.0005 0.0006
Echinococcus granulosus flap endonuclease 1 0.0024 0.0148 0.019
Schistosoma mansoni zinc finger protein 0.0038 0.0337 0.0434
Onchocerca volvulus 0.0017 0.0066 0.0085
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0063 0.0663 0.2693
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0075 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0251 0.0324
Brugia malayi beta-lactamase family protein 0.003 0.0231 0.0298
Echinococcus multilocularis tar DNA binding protein 0.0167 0.202 0.202
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0106 0.1227 0.1582
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0371 0.0371
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0251 0.0787
Brugia malayi jmjC domain containing protein 0.0013 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0251 0.0324
Entamoeba histolytica acyl-CoA synthetase, putative 0.0063 0.0663 0.3672
Brugia malayi Pre-SET motif family protein 0.0167 0.2016 0.26
Mycobacterium leprae conserved hypothetical protein 0.003 0.0231 0.2552
Onchocerca volvulus 0.003 0.0231 0.0298
Brugia malayi CXXC zinc finger family protein 0.0026 0.0178 0.023
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0141 0.1678 1
Brugia malayi T-complex protein 1, beta subunit 0.0019 0.0093 0.012
Schistosoma mansoni lipoxygenase 0.0048 0.047 0.0606
Brugia malayi acetyltransferase, GNAT family protein 0.0135 0.1599 0.2063
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0031 0.0251 0.3031
Echinococcus multilocularis peroxidasin 0.0608 0.7755 0.7755
Echinococcus granulosus cpg binding protein 0.0031 0.024 0.0309
Loa Loa (eye worm) Ulp1 protease 0.0075 0.0817 0.1054
Onchocerca volvulus 0.0024 0.016 0.0206
Echinococcus multilocularis RUN 0.0017 0.0066 0.0066
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0031 0.0251 0.0787
Brugia malayi hypothetical protein 0.0608 0.7755 1
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0141 0.1678 0.2164
Echinococcus granulosus GPCR family 2 0.0057 0.0588 0.0758
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.003 0.0231 0.0298
Mycobacterium ulcerans lipase LipD 0.003 0.0231 0.2654
Entamoeba histolytica hypothetical protein 0.0066 0.0697 0.3884
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0075 0.0075
Brugia malayi hypothetical protein 0.0017 0.0066 0.0085
Loa Loa (eye worm) beta-lactamase 0.003 0.0231 0.0298
Leishmania major acetyl-CoA synthetase, putative 0.0019 0.0083 0.1184
Loa Loa (eye worm) hypothetical protein 0.0608 0.7755 1
Echinococcus multilocularis sentrin specific protease 8 0.0075 0.0817 0.0817
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0019 0.0083 0.0147
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0063 0.0663 1
Onchocerca volvulus 0.0042 0.0391 0.0504
Echinococcus multilocularis cpg binding protein 0.0031 0.024 0.024
Echinococcus multilocularis lipoxygenase domain containing protein 0.0017 0.0066 0.0066
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0013 0.0005 0.0006
Mycobacterium tuberculosis Conserved protein 0.003 0.0231 0.0797
Echinococcus multilocularis jumonji domain containing 1A 0.0013 0.0005 0.0005
Echinococcus multilocularis SAM and MBT domain containing protein 0.0038 0.0338 0.0338
Mycobacterium tuberculosis Probable lipase LipD 0.003 0.0231 0.0797
Echinococcus granulosus histone acetyltransferase KAT2B 0.0127 0.1499 0.1933
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0031 0.0251 0.0324
Loa Loa (eye worm) hypothetical protein 0.0063 0.0663 0.0855
Leishmania major importin beta-1 subunit, putative 0.0037 0.0324 0.4846
Schistosoma mansoni phd/f-box containing protein 0.0013 0.0005 0.0006
Echinococcus granulosus tar DNA binding protein 0.0167 0.202 0.2605
Plasmodium falciparum importin beta, putative 0.0046 0.0436 0.9576
Brugia malayi RNA binding protein 0.0167 0.202 0.2605
Echinococcus multilocularis sentrin specific protease 7 0.0141 0.1678 0.1678
Entamoeba histolytica hypothetical protein 0.0037 0.0324 0.1554
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.003 0.0231 0.0298
Leishmania major 4-coumarate:coa ligase-like protein 0.0063 0.0663 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0063 0.0663 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0019 0.0083 0.0147
Schistosoma mansoni methyl-cpg binding protein mbd 0.0029 0.022 0.0283
Trichomonas vaginalis penicillin-binding protein, putative 0.003 0.0231 0.0697
Trichomonas vaginalis Sentrin-specific protease, putative 0.0075 0.0817 0.3314
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0085
Echinococcus granulosus SAM and MBT domain containing protein 0.0038 0.0338 0.0436
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0019 0.0093 0.1092
Echinococcus multilocularis sentrin specific protease 1 0.0031 0.0251 0.0251
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0024 0.0148 0.2172
Trypanosoma cruzi hypothetical protein 0.0075 0.0817 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0019 0.0083 0.0083
Loa Loa (eye worm) acetyltransferase 0.0135 0.1599 0.2063
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0024 0.016 0.016
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0135 0.1599 0.2063
Mycobacterium tuberculosis Probable hydrolase 0.003 0.0231 0.0797
Brugia malayi mbt repeat family protein 0.0038 0.0338 0.0436
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0037 0.0324 0.1112
Plasmodium falciparum histone acetyltransferase GCN5 0.0035 0.0301 0.6574
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0047 0.0454 0.0585
Echinococcus multilocularis expressed conserved protein 0.011 0.1268 0.1268
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0047 0.0454 0.0454
Schistosoma mansoni aldehyde dehydrogenase 0.0053 0.0533 0.0687
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0057 0.0588 0.0758
Trypanosoma brucei importin beta-1 subunit, putative 0.0046 0.0436 1
Schistosoma mansoni phosphatidylserine receptor 0.0013 0.0005 0.0006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0056 0.0567 0.0732
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0231 0.524
Schistosoma mansoni jumonji domain containing protein 0.0047 0.0454 0.0585
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0047 0.0456 0.1782
Mycobacterium tuberculosis Probable lipase LipE 0.003 0.0231 0.0797
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0031 0.0251 0.0787
Mycobacterium tuberculosis Probable conserved lipoprotein 0.003 0.0231 0.0797
Plasmodium falciparum sentrin-specific protease 1 0.0031 0.0251 0.5463
Onchocerca volvulus Peroxidasin homolog 0.0608 0.7755 1
Entamoeba histolytica hypothetical protein 0.0066 0.0697 0.3884
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0031 0.0251 0.4242
Echinococcus granulosus histone acetyltransferase MYST2 0.0043 0.0407 0.0525
Loa Loa (eye worm) hypothetical protein 0.0077 0.0848 0.1094
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0057 0.0588 0.0588
Brugia malayi beta-lactamase 0.003 0.0231 0.0298
Onchocerca volvulus Peroxidase homolog 0.0608 0.7755 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0017 0.0066 0.0066
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0083 0.0107
Loa Loa (eye worm) hypothetical protein 0.0043 0.0407 0.0525
Mycobacterium ulcerans aldehyde dehydrogenase 0.0053 0.0533 0.7784
Loa Loa (eye worm) Ulp1 protease 0.0031 0.0251 0.0324
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0019 0.0083 0.0136
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0042 0.0391 0.0504
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0019 0.0083 0.0107
Loa Loa (eye worm) hypothetical protein 0.003 0.0231 0.0298
Schistosoma mansoni acetyl-CoA synthetase 0.0019 0.0083 0.0107
Echinococcus granulosus geminin 0.0451 0.5708 0.736
Onchocerca volvulus 0.0019 0.0083 0.0107
Echinococcus multilocularis JmjC domain containing protein 4 0.0013 0.0005 0.0005
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0063 0.0663 1
Loa Loa (eye worm) TAR-binding protein 0.0167 0.202 0.2605
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0395 0.051
Echinococcus granulosus fetal alzheimer antigen falz 0.004 0.0361 0.0465
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0019 0.0083 0.0147
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0034 0.0279 0.6091
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0031 0.0251 0.0787
Brugia malayi AMP-binding enzyme family protein 0.0063 0.0663 0.0855
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0053 0.0533 0.2121
Loa Loa (eye worm) hypothetical protein 0.0054 0.0538 0.0694
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0181 0.2201 0.2838
Loa Loa (eye worm) MBCTL1 0.0043 0.0407 0.0525
Trypanosoma cruzi ISWI complex protein 0.0026 0.0181 0.2166
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0456 0.647
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0538 0.0694
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0019 0.0093 0.012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0121 0.1411 0.182
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0231 0.2783
Loa Loa (eye worm) blistered cuticle protein 3 0.0608 0.7755 1
Leishmania major T-complex protein 1, beta subunit, putative 0.0019 0.0093 0.1348
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0019 0.0083 0.1343
Loa Loa (eye worm) flap endonuclease-1 0.0024 0.0148 0.019
Plasmodium vivax importin-beta 2, putative 0.0046 0.0436 0.9576
Giardia lamblia Flap structure-specific endonuclease 0.0024 0.0148 0.3229
Onchocerca volvulus Chorion peroxidase homolog 0.0608 0.7755 1
Onchocerca volvulus 0.0017 0.0066 0.0085
Schistosoma mansoni cpg binding protein 0.0026 0.0178 0.023
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0047 0.0456 1
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0231 0.0697
Schistosoma mansoni hypothetical protein 0.0057 0.0588 0.0758
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0083 0.0136
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0638 0.0823
Loa Loa (eye worm) hypothetical protein 0.0608 0.7755 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0063 0.0663 0.3672
Onchocerca volvulus 0.0026 0.0178 0.023
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0019 0.0083 0.0136
Onchocerca volvulus 0.0019 0.0083 0.0107
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0019 0.0093 0.0093
Onchocerca volvulus 0.0038 0.0338 0.0436
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.016 0.0206
Plasmodium vivax acyl-CoA synthetase, putative 0.0047 0.0456 1
Echinococcus granulosus survival motor neuron protein 1 0.0207 0.2535 0.3269
Schistosoma mansoni hypothetical protein 0.0039 0.0351 0.0453
Leishmania major hypothetical protein, conserved 0.0026 0.0181 0.2672
Entamoeba histolytica Flap nuclease, putative 0.0024 0.0148 0.0456
Brugia malayi Blistered cuticle protein 3 0.0608 0.7755 1
Brugia malayi jmjC domain containing protein 0.0052 0.0515 0.0665
Schistosoma mansoni transcription factor LCR-F1 0.0066 0.0697 0.0899
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0371 0.0478
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0031 0.0251 0.11
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0063 0.0663 1
Schistosoma mansoni rab6-interacting 0.0017 0.0066 0.0085
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0075 0.0096
Leishmania major GTP-binding protein, putative 0.0034 0.0279 0.4169
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0121 0.1411 0.182
Schistosoma mansoni hypothetical protein 0.0042 0.0391 0.0504
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.1075 0.6236
Loa Loa (eye worm) bromodomain containing protein 0.0033 0.0275 0.0355
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0034 0.0279 0.3379
Echinococcus multilocularis histone acetyltransferase MYST2 0.0043 0.0407 0.0407
Echinococcus granulosus Polycystic kidney disease protein 0.0017 0.0066 0.0085
Echinococcus multilocularis importin subunit beta 1 0.0046 0.0436 0.0436
Schistosoma mansoni hypothetical protein 0.0035 0.0299 0.0386
Plasmodium falciparum T-complex protein 1 subunit beta 0.0019 0.0093 0.1969
Loa Loa (eye worm) hypothetical protein 0.0608 0.7755 1
Echinococcus granulosus beta LACTamase domain containing family member 0.003 0.0231 0.0298
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0045 0.0422 0.1635
Brugia malayi AMP-binding enzyme family protein 0.0063 0.0663 0.0855
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0075 0.1552
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0034 0.0279 0.4729
Echinococcus granulosus phd:f box containing protein 0.0013 0.0005 0.0006
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0019 0.0083 0.096
Loa Loa (eye worm) hypothetical protein 0.0608 0.7755 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0395 0.6728
Loa Loa (eye worm) hypothetical protein 0.0608 0.7755 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0085
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0031 0.0251 0.0787
Schistosoma mansoni ap endonuclease 0.0018 0.0075 0.0096
Brugia malayi Bromodomain containing protein 0.0069 0.0733 0.0945
Schistosoma mansoni hypothetical protein 0.0026 0.0181 0.0233
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.1075 0.1386
Brugia malayi mbt repeat family protein 0.0038 0.0338 0.0436
Echinococcus multilocularis expressed conserved protein 0.0089 0.1 0.1
Schistosoma mansoni sex comb on midleg homolog 0.0038 0.0338 0.0436
Schistosoma mansoni tar DNA-binding protein 0.0167 0.202 0.2605
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0034 0.0279 0.036
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0075 0.0817 0.3314
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0019 0.0083 0.096
Loa Loa (eye worm) hypothetical protein 0.0095 0.1075 0.1386
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0063 0.0663 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.004 0.0361 0.0465
Echinococcus granulosus snurportin 1 0.0488 0.6195 0.7989
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0031 0.0251 0.4242
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0019 0.0093 0.012
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0019 0.0083 0.0136
Echinococcus multilocularis Polycystic kidney disease protein 0.0017 0.0066 0.0066
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0121 0.1411 0.1411
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0031 0.0251 0.11
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.003 0.0231 0.0797
Loa Loa (eye worm) T-complex protein 1 0.0019 0.0093 0.012
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0395 0.8665
Plasmodium vivax flap endonuclease 1, putative 0.0024 0.0148 0.3173
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0019 0.0083 0.0107
Loa Loa (eye worm) hypothetical protein 0.0608 0.7755 1
Schistosoma mansoni peroxidasin 0.0608 0.7755 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0121 0.1411 0.182
Schistosoma mansoni hypothetical protein 0.0057 0.0588 0.0758
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0031 0.0251 0.0324
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0075 0.0817 0.3314
Loa Loa (eye worm) mbt repeat family protein 0.0038 0.0338 0.0436
Brugia malayi RNA, U transporter 1 0.013 0.1534 0.1978
Schistosoma mansoni hypothetical protein 0.0017 0.0066 0.0085
Schistosoma mansoni aldehyde dehydrogenase 0.0053 0.0533 0.0687
Echinococcus granulosus lysine specific demethylase 5A 0.0052 0.0515 0.0665
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0107
Schistosoma mansoni hypothetical protein 0.0451 0.5708 0.736
Schistosoma mansoni ran 0.0034 0.0279 0.036
Loa Loa (eye worm) hypothetical protein 0.0057 0.0588 0.0758
Loa Loa (eye worm) hypothetical protein 0.0608 0.7755 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0075 0.1552
Toxoplasma gondii propionate-CoA ligase 0.0019 0.0083 0.1343
Trypanosoma brucei SUMO1/Ulp2, putative 0.0031 0.0251 0.5706
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0019 0.0083 0.0107
Onchocerca volvulus Dual oxidase homolog 0.0608 0.7755 1
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0031 0.0251 0.3031
Loa Loa (eye worm) jmjC domain-containing protein 0.0013 0.0005 0.0006
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0075 0.0817 0.4632
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0034 0.0279 0.6361
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0019 0.0083 0.0147
Trypanosoma cruzi ISWI complex protein 0.0026 0.0181 0.2166
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0019 0.0083 0.0107
Leishmania major hypothetical protein, conserved 0.003 0.0231 0.3434
Loa Loa (eye worm) hypothetical protein 0.0063 0.0663 0.0855
Toxoplasma gondii t-complex protein beta subunit 0.0019 0.0093 0.1529
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0019 0.0093 0.012
Loa Loa (eye worm) hypothetical protein 0.0031 0.0251 0.0324
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0638 0.0638
Echinococcus granulosus sentrin specific protease 8 0.0075 0.0817 0.1054
Trichomonas vaginalis antibiotic synthetase, putative 0.0019 0.0083 0.0036
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0019 0.0083 0.096
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0066 0.0085
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0043 0.0407 0.0525
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0083 0.0107
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0031 0.0251 0.11
Plasmodium falciparum LCCL domain-containing protein 0.0017 0.0066 0.1358
Loa Loa (eye worm) hypothetical protein 0.003 0.0231 0.0298
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0083 0.0107
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0019 0.0083 0.1807
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0107
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0106 0.1227 0.1227
Schistosoma mansoni ran 0.0034 0.0279 0.036
Brugia malayi beta-lactamase family protein 0.003 0.0231 0.0298
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.0178 0.023
Plasmodium vivax sentrin-specific protease 1, putative 0.0031 0.0251 0.5463
Loa Loa (eye worm) hypothetical protein 0.0124 0.1454 0.1875
Schistosoma mansoni jumonji/arid domain-containing protein 0.0052 0.0515 0.0665
Schistosoma mansoni bromodomain containing protein 0.0113 0.1306 0.1684
Onchocerca volvulus Peroxidasin homolog 0.0608 0.7755 1
Toxoplasma gondii exonuclease III APE 0.0018 0.0075 0.1205
Brugia malayi latrophilin 2 splice variant baaae 0.0124 0.1454 0.1875
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0154 0.1846 0.2381
Loa Loa (eye worm) hypothetical protein 0.005 0.049 0.0631
Schistosoma mansoni tar DNA-binding protein 0.0167 0.202 0.2605
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0075 0.1062
Brugia malayi TAR-binding protein 0.0167 0.202 0.2605
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0075 0.0817 0.3314
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0075 0.0112
Brugia malayi AMP-binding enzyme family protein 0.0063 0.0663 0.0855
Onchocerca volvulus 0.0063 0.0663 0.0855
Loa Loa (eye worm) hypothetical protein 0.0608 0.7755 1
Trichomonas vaginalis chaperonin, putative 0.0019 0.0093 0.0084
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0488 0.6195 0.7989
Brugia malayi PHD-finger family protein 0.0047 0.0455 0.0587
Loa Loa (eye worm) animal heme peroxidase 0.0608 0.7755 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0019 0.0083 0.0136
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0043 0.0407 0.0407
Echinococcus multilocularis GPCR, family 2 0.0057 0.0588 0.0588
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0299 0.0386
Brugia malayi Doublecortin family protein 0.0017 0.0066 0.0085
Schistosoma mansoni hypothetical protein 0.0451 0.5708 0.736
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0023 0.0141 0.0181
Loa Loa (eye worm) hypothetical protein 0.0046 0.0436 0.0563
Loa Loa (eye worm) hypothetical protein 0.0047 0.0456 0.0587
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0083 0.0147
Echinococcus multilocularis lysine specific demethylase 5A 0.0047 0.0454 0.0454
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0045 0.0422 0.1635
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.1075 0.1075
Schistosoma mansoni hypothetical protein 0.0039 0.0351 0.0453
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0031 0.0251 0.374
Echinococcus multilocularis lysine specific demethylase 6a 0.0013 0.0005 0.0005
Brugia malayi Animal haem peroxidase family protein 0.0608 0.7755 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.003 0.0231 0.0797
Echinococcus granulosus polycomb protein SCMH1 0.0038 0.0338 0.0436
Echinococcus granulosus importin subunit beta 1 0.0046 0.0436 0.0563
Schistosoma mansoni hypothetical protein 0.0057 0.0588 0.0758
Loa Loa (eye worm) animal heme peroxidase 0.0608 0.7755 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0038 0.0338 0.0436
Echinococcus granulosus sentrin specific protease 1 0.0031 0.0251 0.0324
Entamoeba histolytica hypothetical protein 0.0066 0.0697 0.3884
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.016 0.0206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0083 0.0147
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0075 0.0096
Plasmodium falciparum flap endonuclease 1 0.0024 0.0148 0.3173
Loa Loa (eye worm) hypothetical protein 0.0608 0.7755 1
Brugia malayi CHE-14 protein 0.0041 0.0371 0.0478
Schistosoma mansoni importin beta-1 0.0046 0.0436 0.0563
Schistosoma mansoni myelin transcription factor 1 myt1 0.0043 0.0407 0.0525
Loa Loa (eye worm) hypothetical protein 0.0047 0.0456 0.0587
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0083 0.0136
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0395 0.1431
Trypanosoma cruzi importin beta-1 subunit, putative 0.0037 0.0324 0.3928
Echinococcus granulosus jumonji domain containing 1A 0.0013 0.0005 0.0006
Brugia malayi hypothetical protein 0.0207 0.2535 0.3269
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0019 0.0083 0.0136
Toxoplasma gondii HEAT repeat-containing protein 0.0046 0.0436 0.7435
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0083 0.0136
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0395 0.6728
Schistosoma mansoni protein phosphatase 2C 0.0013 0.0005 0.0006
Echinococcus granulosus sentrin specific protease 7 0.0141 0.1678 0.2164
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0075 0.0817 0.1054
Loa Loa (eye worm) hypothetical protein 0.0608 0.7755 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0083 0.0136
Echinococcus multilocularis survival motor neuron protein 1 0.0207 0.2535 0.2535
Mycobacterium ulcerans acyl-CoA synthetase 0.0063 0.0663 1
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0031 0.0251 0.11
Brugia malayi Latrophilin receptor protein 2 0.0057 0.0588 0.0758
Loa Loa (eye worm) hypothetical protein 0.0065 0.0692 0.0893
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0066 0.0066
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0066 0.0697 0.0697
Mycobacterium tuberculosis Conserved protein 0.003 0.0231 0.0797
Onchocerca volvulus 0.0608 0.7755 1
Schistosoma mansoni cpg binding protein 0.0031 0.024 0.0309
Plasmodium vivax multidomain scavenger receptor, putative 0.0017 0.0066 0.1358
Entamoeba histolytica Ran family GTPase 0.0034 0.0279 0.1276
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0041 0.0371 0.0478
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0019 0.0083 0.0147
Echinococcus granulosus expressed conserved protein 0.011 0.1268 0.1636
Schistosoma mansoni loxhd1 0.0017 0.0066 0.0085
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0037 0.0324 0.1112
Schistosoma mansoni hypothetical protein 0.0124 0.1454 0.1875
Loa Loa (eye worm) hypothetical protein 0.0608 0.7755 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0006
Echinococcus granulosus peroxidasin 0.0608 0.7755 1
Loa Loa (eye worm) oxidoreductase 0.0019 0.0083 0.0107
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0019 0.0093 0.2056
Echinococcus granulosus expressed conserved protein 0.0089 0.1 0.1289
Mycobacterium ulcerans acyl-CoA synthetase 0.0063 0.0663 1
Brugia malayi Animal haem peroxidase family protein 0.0608 0.7755 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0013 0.0005 0.0006
Schistosoma mansoni hypothetical protein 0.0066 0.0697 0.0899
Echinococcus multilocularis snurportin 1 0.0488 0.6195 0.6195
Onchocerca volvulus 0.003 0.0231 0.0298
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0135 0.1599 0.1599
Mycobacterium tuberculosis Probable esterase LipL 0.003 0.0231 0.0797
Plasmodium vivax acetyl-CoA synthetase, putative 0.0019 0.0083 0.173
Mycobacterium tuberculosis Conserved protein 0.003 0.0231 0.0797
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0031 0.0251 0.4242
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0019 0.0083 0.0136
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.003 0.0231 0.2654
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0083 0.0136
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0019 0.0083 0.096
Onchocerca volvulus 0.003 0.0231 0.0298
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0043 0.0407 0.0525
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0019 0.0083 0.0147
Echinococcus multilocularis protein patched 0.0041 0.0371 0.0371
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0063 0.0663 1
Mycobacterium leprae Probable lipase LipE 0.003 0.0231 0.2552
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0048 0.047 0.047
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0231 0.0697
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0181 0.2201 0.2838
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0019 0.0083 0.005
Loa Loa (eye worm) doublecortin family protein 0.0017 0.0066 0.0085
Loa Loa (eye worm) hypothetical protein 0.0608 0.7755 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0063 0.0663 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0029 0.022 0.0283
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0053 0.0533 0.0533
Loa Loa (eye worm) hypothetical protein 0.0608 0.7755 1
Brugia malayi Pre-SET motif family protein 0.0024 0.016 0.0206
Echinococcus multilocularis polycomb protein SCMH1 0.0038 0.0338 0.0338
Leishmania major 4-coumarate:coa ligase-like protein 0.0063 0.0663 1
Mycobacterium ulcerans hypothetical protein 0.0063 0.0663 1
Onchocerca volvulus Peroxidase homolog 0.0608 0.7755 1
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0371 0.0478
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0024 0.0148 0.3314
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0034 0.0279 0.3379
Schistosoma mansoni tar DNA-binding protein 0.0167 0.202 0.2605
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0083 0.0147
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0031 0.0251 0.0787
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0019 0.0083 0.0136
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0231 0.2783
Brugia malayi hypothetical protein 0.0066 0.0697 0.0899
Trichomonas vaginalis penicillin-binding protein, putative 0.003 0.0231 0.0697
Onchocerca volvulus 0.0019 0.0083 0.0107
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0154 0.1846 0.1846
Loa Loa (eye worm) animal heme peroxidase 0.0608 0.7755 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0456 0.0587
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0019 0.0083 0.0147
Echinococcus granulosus histone lysine methyltransferase setb 0.0054 0.0538 0.0694
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0057 0.0588 0.0758
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0121 0.1411 0.182
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0048 0.047 0.0606
Loa Loa (eye worm) RNA binding protein 0.0167 0.202 0.2605
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0083 0.0136
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0031 0.0251 0.0324
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0019 0.0083 0.1807
Schistosoma mansoni ap endonuclease 0.0018 0.0075 0.0096
Schistosoma mansoni survival motor neuron protein 0.0042 0.0391 0.0504
Echinococcus granulosus methyl CpG binding domain protein 2 0.0029 0.022 0.0283
Entamoeba histolytica acetyltransferase, GNAT family 0.0035 0.0301 0.1412
Loa Loa (eye worm) hypothetical protein 0.003 0.0231 0.0298
Schistosoma mansoni hypothetical protein 0.0488 0.6195 0.7989
Brugia malayi Peroxidasin 0.0608 0.7755 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.004 0.0361 0.0361
Echinococcus multilocularis protein dispatched 1 0.0046 0.0445 0.0445
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0083 0.0136
Mycobacterium ulcerans aldehyde dehydrogenase 0.0053 0.0533 0.7784
Echinococcus multilocularis zinc finger protein 0.0038 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0047 0.0456 0.0587
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.003 0.0231 0.0298
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0075 0.1621
Trichomonas vaginalis set domain proteins, putative 0.019 0.2316 1
Loa Loa (eye worm) hypothetical protein 0.0207 0.2535 0.3269
Onchocerca volvulus 0.0608 0.7755 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0013 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0121 0.141 0.1818
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0083 0.0107
Trichomonas vaginalis importin beta-1, putative 0.0037 0.0324 0.1112
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0031 0.0251 0.0787
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0019 0.0083 0.173

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 0.075 uM Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain expressed in bacterial expression system assessed as inhibition of SRC1 co-activator peptide recruitment after 3 hrs by TR-FRET analysis ChEMBL. 25453817
Efficacy (binding) = -84 % Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain expressed in bacterial expression system assessed as inhibition of SRC1 co-activator peptide recruitment at 10 uM after 3 hrs by TR-FRET analysis relative to apo-RORc basal activity ChEMBL. 25453817
IC50 (binding) = 0.014 uM Displacement of [3H]25-hydroxycholesterol from human RORc-LBD expressed in bacterial expression system after 3 hrs by scintillation counting analysis ChEMBL. 25453817

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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