Detailed information for compound 992081

Basic information

Technical information
  • TDR Targets ID: 992081
  • Name: 1-[(5-bromo-2-oxoindol-3-yl)amino]-3-(4-nitro phenyl)thiourea
  • MW: 420.241 | Formula: C15H10BrN5O3S
  • H donors: 3 H acceptors: 3 LogP: 3.56 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(Nc1ccc(cc1)[N+](=O)[O-])N/N=C/1\C(=O)Nc2c1cc(Br)cc2
  • InChi: 1S/C15H10BrN5O3S/c16-8-1-6-12-11(7-8)13(14(22)18-12)19-20-15(25)17-9-2-4-10(5-3-9)21(23)24/h1-7H,(H2,17,20,25)(H,18,19,22)
  • InChiKey: IKCIOMBDYMAAMD-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-[(5-bromo-2-oxo-indol-3-yl)amino]-3-(4-nitrophenyl)thiourea
  • 1-[(5-bromo-2-oxo-3-indolyl)amino]-3-(4-nitrophenyl)thiourea
  • 1-[(5-bromo-2-keto-indol-3-yl)amino]-3-(4-nitrophenyl)thiourea
  • NSC716772
  • NCI60_040348

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0144 0.0421
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0096
Brugia malayi Cytochrome P450 family protein 0.0029 0.0051 0.0142
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0085 0.022 0.0437
Giardia lamblia Kinase, CMGC CK2 0.0134 0.037 0.1649
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0144 0.0421
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0005 0.0005
Onchocerca volvulus 0.0231 0.0662 0.7213
Mycobacterium ulcerans putative regulatory protein 0.0019 0.002 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.0532 0.1557
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0071 0.0153
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0005 0.0011
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0144 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0406 0.1193 0.3488
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0019 0.0019
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0144 0.0421
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0071 0.0153
Echinococcus granulosus geminin 0.0165 0.0463 0.0463
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.005 0.0145
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0034 0.0065 0.0065
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0144 0.0421
Echinococcus multilocularis musashi 0.0026 0.0042 0.0042
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0042 0.0095
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.0532 0.1557
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0105 0.0281 0.0817
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.005 0.0351
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0085 0.022 0.022
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0069 0.0069
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0051 0.0357
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0486 0.1436 0.1436
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0144 0.0898
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.114 0.3419 1
Echinococcus multilocularis Ankyrin 0.0014 0.0006 0.0006
Brugia malayi Cytochrome P450 family protein 0.0019 0.002 0.0052
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0315 0.0918 0.0918
Trichomonas vaginalis PIKK family atypical protein kinase 0.0133 0.0365 0.1067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0323 0.0943 0.2757
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0209
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0029 0.0055
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0237 0.0681 0.1985
Entamoeba histolytica hypothetical protein 0.0035 0.0069 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0019 0.0057
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0114 0.0333
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0439 0.1294 0.3784
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.002 0.0045
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0134 0.037 0.5398
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0144 0.0421
Schistosoma mansoni survival motor neuron protein 0.0094 0.0248 0.0493
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0209
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0019 0.0019
Entamoeba histolytica hypothetical protein 0.0105 0.0281 0.077
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0069 0.0135
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.037 0.1081
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0019 0.0057
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0105 0.0281 0.0822
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0286 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0019 0.005
Brugia malayi Cytochrome P450 family protein 0.0019 0.002 0.0052
Brugia malayi SH2 domain containing protein 0.0333 0.0973 0.2842
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0486 0.1436 0.2872
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0144 0.0421
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0036 0.0071 0.0518
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0086 0.0193
Giardia lamblia Kinase, PLK 0.0188 0.0532 0.2487
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0474 0.1399 0.2798
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0105 0.0281 0.4089
Schistosoma mansoni protein kinase 0.0134 0.037 0.0736
Loa Loa (eye worm) phosphatidylinositol 3 0.0474 0.1399 0.3158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.1315 0.3846
Trichomonas vaginalis PIKK family atypical protein kinase 0.0411 0.121 0.354
Leishmania major hypothetical protein, unknown function 0.0105 0.0281 0.0755
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0029 0.0055
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0315 0.0918 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0286 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0237 0.0681 1
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.005 0.0114 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0051 0.0097
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0752 0.2244 0.2244
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0005 0.0005
Brugia malayi hypothetical protein 0.0019 0.0019 0.005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0069 0.0069
Toxoplasma gondii hypothetical protein 0.0019 0.002 0.0122
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0144 0.0421
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.0071 0.0982
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0263 0.076 0.2218
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0446 0.1316 0.9394
Brugia malayi Pre-SET motif family protein 0.0029 0.0051 0.0141
Schistosoma mansoni hypothetical protein 0.0105 0.0281 0.0559
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0086 0.0086
Loa Loa (eye worm) phosphatidylinositol 3 0.1473 0.443 1
Brugia malayi Pre-SET motif family protein 0.0203 0.0577 0.1681
Brugia malayi intermediate filament protein 0.0026 0.0042 0.0117
Brugia malayi hypothetical protein 0.0035 0.0069 0.0197
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0248 0.072
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.002 0.0059
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0105 0.0281 0.2146
Brugia malayi Protein kinase domain containing protein 0.0131 0.036 0.1048
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0042 0.0117
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0237 0.0681 0.0681
Brugia malayi hypoxia-induced factor 1 0.0148 0.041 0.1194
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0019 0.005
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0209
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0237 0.0681 0.1945
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0122 0.0356
Brugia malayi hypothetical protein 0.016 0.0448 0.1304
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0044
Entamoeba histolytica hypothetical protein 0.0035 0.0069 0.0147
Entamoeba histolytica protein kinase domain containing protein 0.005 0.0114 0.0278
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0019 0.0019
Brugia malayi 6-phosphofructokinase 0.0107 0.0286 0.083
Brugia malayi intracellular kinase 0.005 0.0114 0.0327
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.114 0.3419 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0002
Toxoplasma gondii FATC domain-containing protein 0.0263 0.076 0.5861
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0072 0.0211
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0034 0.0065 0.0185
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0019 0.005
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0047 0.0047
Entamoeba histolytica hypothetical protein 0.0954 0.2855 0.8341
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0144 0.0421
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0086 0.0244
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0012 0.002
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0006 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0474 0.1399 0.4092
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0084 0.0164
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.331 1 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0105 0.0281 0.0635
Schistosoma mansoni hypothetical protein 0.015 0.0419 0.0834
Schistosoma mansoni hypothetical protein 0.0014 0.0005 0.0006
Echinococcus multilocularis cyclin dependent kinase 19 0.0131 0.036 0.036
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0051 0.0051
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0315 0.0918 0.2071
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0019 0.0034
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0144 0.0421
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.001 0.0029
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0105 0.0281 0.2146
Giardia lamblia Kinase, CMGC GSK 0.005 0.0114 0.0331
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0105 0.0281 0.0281
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.005 1
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0019 0.0019
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0131 0.036 0.0813
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0286 0.0767
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0019 0.0034
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0237 0.0681 0.199
Echinococcus multilocularis lamin 0.0026 0.0042 0.0042
Brugia malayi Protein kinase domain containing protein 0.0315 0.0918 0.2679
Brugia malayi PXA domain containing protein 0.002 0.0024 0.0063
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0064
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0188 0.0532 0.1429
Loa Loa (eye worm) hypothetical protein 0.0752 0.2244 0.5066
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0188 0.0532 0.0532
Schistosoma mansoni hypothetical protein 0.0094 0.0248 0.0493
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0286 1
Echinococcus granulosus single minded 2 0.0039 0.008 0.008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0051 0.0097
Loa Loa (eye worm) phosphatidylinositol 3 0.0105 0.0281 0.0635
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.037 0.1081
Toxoplasma gondii ck2 beta subunit 0.0036 0.0071 0.0518
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.114 0.3419 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0034 0.0065 0.0065
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0286 0.0783
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0071 0.0153
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.0071 0.0982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0281 0.0822
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0144 0.0421
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0209
Plasmodium vivax SET domain protein, putative 0.0029 0.0051 0.0674
Echinococcus granulosus expressed conserved protein 0.008 0.0205 0.0205
Echinococcus granulosus casein kinase ii subunit alpha 0.0134 0.037 0.037
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0144 0.0421
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0064
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0286 0.0835
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0286 0.0568
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0002 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.0532 0.1557
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0044
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.002 0.0045
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0486 0.1436 0.42
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0109 0.0215
Loa Loa (eye worm) hypothetical protein 0.0029 0.0051 0.0114
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0209
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0002 0.0002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0474 0.1399 0.4088
Loa Loa (eye worm) hypothetical protein 0.0256 0.0738 0.1665
Brugia malayi hypothetical protein 0.0099 0.0262 0.0759
Loa Loa (eye worm) hypothetical protein 0.0026 0.0041 0.0092
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0474 0.1399 0.4092
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0026 0.0043 0.0118
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0005 0.0012
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0474 0.1399 0.4092
Plasmodium falciparum glycogen synthase kinase 3 0.005 0.0114 0.1452
Echinococcus granulosus voltage dependent calcium channel 0.0034 0.0065 0.0065
Loa Loa (eye worm) gastrulation defective protein 1 0.0128 0.035 0.079
Leishmania major phosphatidylinositol 4-kinase, putative 0.0105 0.0281 0.0755
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0423 0.1245 0.364
Loa Loa (eye worm) CYP4Cod1 0.0019 0.002 0.0045
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.005 0.0483
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0384 0.1126 0.8023
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0085 0.022 0.022
Giardia lamblia Casein kinase II beta chain 0.0036 0.0071 0.0111
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0209
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0005 0.0056
Entamoeba histolytica hypothetical protein 0.0263 0.076 0.2179
Loa Loa (eye worm) Csnk2b protein 0.0036 0.0071 0.0161
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0286 0.0645
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0474 0.1399 1
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.002 0.0059
Entamoeba histolytica protein kinase, putative 0.005 0.0114 0.0278
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0001 0.0001
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0069 0.0197
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0144 0.0421
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0249 0.0728
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.114 0.3419 1
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0019 0.0019
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0446 0.1316 0.353
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0256 0.0738 0.5685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0384 0.1126 0.3294
Echinococcus granulosus lamin 0.0026 0.0042 0.0042
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.0071 0.0777
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0105 0.0281 0.1894
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.037 0.1081
Toxoplasma gondii GAF domain-containing protein 0.0019 0.002 0.0122
Schistosoma mansoni hypothetical protein 0.0035 0.0069 0.0135
Trypanosoma brucei Casein kinase II 0.0134 0.037 0.2535
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0034
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0144 0.0421
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0019 0.0034
Schistosoma mansoni hypothetical protein 0.0165 0.0463 0.0922
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0105 0.0281 0.0822
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.005 0.0114 0.0333
Echinococcus granulosus protein kinase shaggy 0.005 0.0114 0.0114
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0026 0.0043 0.0043
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0144 0.0421
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0087 0.0228 0.0228
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.114 0.3419 1
Plasmodium falciparum casein kinase II beta chain 0.0036 0.0071 0.0809
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0233 0.067 0.196
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0105 0.0281 0.0822
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0029
Echinococcus granulosus glycogen synthase kinase 3 beta 0.005 0.0114 0.0114
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0034 0.0065 0.0065
Plasmodium vivax hypothetical protein 0.0105 0.0281 0.4089
Schistosoma mansoni serine/threonine protein kinase 0.0315 0.0918 0.1834
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0105 0.0281 0.0559
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0233 0.067 0.1955
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.001 0.0029
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.005 0.0145
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0237 0.0681 0.199
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0954 0.2855 0.8341
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0034 0.0065 0.0065
Leishmania major phosphatidylinositol 3-kinase, putative 0.0237 0.0681 0.1826
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0019 0.0019
Trypanosoma cruzi casein kinase II, putative 0.0134 0.037 0.1081
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0144 0.0421
Plasmodium vivax glycogen synthase kinase 3, putative 0.005 0.0114 0.1613
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0255 0.0736 0.2108
Loa Loa (eye worm) hypothetical protein 0.0035 0.007 0.0158
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.015 0.0419 0.1225
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0755 0.2251 0.6582
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0237 0.0681 0.1536
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0144 0.0421
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0519 0.1538 0.4493
Echinococcus multilocularis expressed protein 0.0366 0.1072 0.1072
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0474 0.1399 0.4058
Brugia malayi Uncoordinated protein 44 0.0014 0.0005 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0439 0.1294 0.3784
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0315 0.0918 0.2679
Trichomonas vaginalis PIKK family atypical protein kinase 0.0439 0.1294 0.3784
Loa Loa (eye worm) hypothetical protein 0.0333 0.0973 0.2197
Echinococcus multilocularis voltage dependent calcium channel 0.0034 0.0065 0.0065
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0286 0.0286
Plasmodium falciparum GAF domain-related protein, putative 0.0019 0.002 0.0037
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0036 0.0071 0.0372
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0105 0.0281 0.0281
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.037 0.1081
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0144 0.0421
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0105 0.0281 0.0817
Loa Loa (eye worm) hypothetical protein 0.0432 0.1272 0.2872
Mycobacterium leprae conserved hypothetical protein 0.0105 0.0281 0.9844
Loa Loa (eye worm) phosphatidylinositol 3 0.0105 0.0281 0.0635
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0005 0.0005
Onchocerca volvulus 0.0099 0.0261 0.2848
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0144 0.0421
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.005 0.0114 0.0849
Toxoplasma gondii CMGC kinase, CK2 family 0.0134 0.037 0.2832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.1315 0.3846
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0042 0.0095
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0105 0.0281 0.3975
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.006 0.0144 0.0144
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.005 0.0145
Echinococcus multilocularis voltage dependent calcium channel 0.0034 0.0065 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0439 0.1294 0.3784
Mycobacterium ulcerans putative regulatory protein 0.0019 0.002 0.0007
Entamoeba histolytica hypothetical protein 0.0105 0.0281 0.077
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0005 0.0006
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0069 0.1861
Echinococcus granulosus cyclin dependent kinase 19 0.0131 0.036 0.036
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0286 0.0835
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0001 0.0001
Schistosoma mansoni fkbp-rapamycin associated protein 0.0233 0.067 0.1338
Leishmania major phosphatidylinositol kinase related protein, putative 0.0135 0.0371 0.0996
Trichomonas vaginalis PIKK family atypical protein kinase 0.0289 0.0838 0.245
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.006 0.0144 0.0284
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0105 0.0281 0.0817
Trypanosoma cruzi polo-like protein kinase, putative 0.0188 0.0532 0.1557
Mycobacterium tuberculosis Conserved hypothetical protein 0.0105 0.0281 0.9832
Echinococcus granulosus survival motor neuron protein 1 0.0462 0.1364 0.1364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0418 0.1232 0.3602
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1659 0.4995 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0144 0.0421
Leishmania major protein kinase, putative 0.0021 0.0026 0.0069
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0423 0.1245 0.3604
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0025 0.0068
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0087 0.0228 0.0452
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.1035 0.31 0.9062
Loa Loa (eye worm) phosphatidylinositol 3 0.0105 0.0281 0.0635
Loa Loa (eye worm) hypothetical protein 0.015 0.0419 0.0945
Schistosoma mansoni serine/threonine protein kinase 0.0131 0.036 0.0717
Trichomonas vaginalis PIKK family atypical protein kinase 0.0411 0.121 0.3539
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0002 0.0002
Echinococcus granulosus tumor protein p63 0.0331 0.0967 0.0967
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0286 0.0835
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0096 0.0189
Trypanosoma cruzi polo-like protein kinase, putative 0.0188 0.0532 0.1557
Echinococcus granulosus casein kinase ii subunit beta 0.0036 0.0071 0.0071
Echinococcus multilocularis high voltage activated calcium channel beta 0.0085 0.022 0.022
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.006 0.0144 0.0144
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.006 0.0144 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0474 0.1399 0.4092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0384 0.1126 0.3294
Entamoeba histolytica protein kinase domain containing protein 0.0134 0.037 0.103
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0315 0.0918 0.2071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0051 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0263 0.076 0.2223
Entamoeba histolytica casein kinase, putative 0.0134 0.037 0.103
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0474 0.1399 0.4058
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0577 0.1302
Onchocerca volvulus 0.0026 0.0042 0.0458
Onchocerca volvulus 0.0026 0.0042 0.0458
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.114 0.3419 1
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0025 0.0074
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0209
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0034
Brugia malayi serine/threonine-protein kinase plk-2 0.0188 0.0532 0.1552
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.005 0.0483
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0318 0.0926 0.2708
Toxoplasma gondii target of rapamycin (TOR), putative 0.0439 0.1294 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0042 0.0095
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0105 0.0281 0.0822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0439 0.1294 0.3784
Onchocerca volvulus 0.0105 0.0281 0.3064
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0406 0.1193 0.32
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.005 0.0351
Loa Loa (eye worm) hypothetical protein 0.0158 0.0441 0.0996
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0486 0.1436 0.4196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0474 0.1399 0.4092
Plasmodium falciparum casein kinase 2, alpha subunit 0.0134 0.037 0.5309
Echinococcus multilocularis casein kinase ii subunit beta 0.0036 0.0071 0.0071
Brugia malayi Csnk2b protein 0.0036 0.0071 0.0202
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0019 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0233 0.067 0.196
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0522 0.1545 0.4488
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0209
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0237 0.0681 0.0681
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0237 0.0681 0.1359
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0034 0.0065 0.0127
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0144 0.0421
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.0532 0.1557
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0026 0.0043 0.0081
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0486 0.1436 0.1436
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0286 0.0645
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.016 0.0449 0.3109
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0019 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0439 0.1294 0.3784
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.005 0.0089
Entamoeba histolytica protein kinase domain containing protein 0.005 0.0114 0.0278
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0005 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.037 0.1081
Trypanosoma brucei protein kinase, putative 0.005 0.0114 0.0681
Brugia malayi FAT domain containing protein 0.015 0.0419 0.1219
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0286 0.0783
Schistosoma mansoni hypothetical protein 0.0165 0.0463 0.0922
Entamoeba histolytica hypothetical protein 0.0035 0.0069 0.0147
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0105 0.0281 0.3975
Brugia malayi 6-phosphofructokinase 0.0107 0.0286 0.083
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0046
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0286 0.0286
Echinococcus granulosus bloom syndrome protein 0.0021 0.0025 0.0025
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0105 0.0281 0.4089
Echinococcus multilocularis lamin dm0 0.0026 0.0042 0.0042
Toxoplasma gondii hypothetical protein 0.0019 0.002 0.0122
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0144 0.0421
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0406 0.1193 0.8502
Loa Loa (eye worm) CMGC/GSK protein kinase 0.005 0.0114 0.0257
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0019 0.0019
Onchocerca volvulus 0.0094 0.0248 0.2705
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0019 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0122 0.0356
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.0071 0.0777
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0315 0.0918 0.0918
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0209
Schistosoma mansoni lamin 0.0026 0.0042 0.008
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0026 0.0043 0.0124
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0209
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.001 0.0029
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0233 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0104
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0087 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0099 0.0261 0.059
Plasmodium vivax hypothetical protein, conserved 0.0019 0.002 0.0225
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0237 0.0681 0.5243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0411 0.121 0.3539
Plasmodium vivax unspecified product 0.0134 0.037 0.5398
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0291 0.0845 0.4099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.0351 0.1027
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0024 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0289 0.0838 0.245
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0423 0.1245 0.3636
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.0532 0.1557
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0019 0.0019
Echinococcus granulosus Ankyrin 0.0014 0.0006 0.0006
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0752 0.2244 0.2244
Onchocerca volvulus 0.004 0.0084 0.0917
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0105 0.0281 0.1894
Trypanosoma brucei polo-like protein kinase 0.0188 0.0532 0.3716
Onchocerca volvulus 0.0035 0.0069 0.0757
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0105 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0012
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0286 0.1926
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0474 0.1399 0.1399
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0086 0.0086
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0019 0.0019
Giardia lamblia Phosphatidylinositol 4-kinase 0.0105 0.0281 0.1193
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0474 0.1399 0.3755
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0286 0.0645
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0175 0.0494 0.1115
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0423 0.1245 0.364
Schistosoma mansoni hypothetical protein 0.008 0.0205 0.0406
Loa Loa (eye worm) hypothetical protein 0.0233 0.067 0.1513
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0263 0.076 0.2223
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0237 0.0681 0.1826
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0423 0.1245 0.8879
Echinococcus granulosus intermediate filament protein 0.0026 0.0042 0.0042
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0237 0.0681 0.0681
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.1315 0.3846
Entamoeba histolytica hypothetical protein 0.0105 0.0281 0.077
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.005 0.0662
Giardia lamblia GTOR 0.0474 0.1399 0.6953
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0233 0.067 0.067
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.005 0.0662
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0036 0.0071 0.0191
Brugia malayi PAS domain containing protein 0.0048 0.0107 0.0307
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0144 0.0421
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.006 0.0144 0.0421
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1659 0.4995 0.4995
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0019 0.0034
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0105 0.0281 0.0822
Brugia malayi PXA domain containing protein 0.002 0.0024 0.0063
Echinococcus multilocularis survival motor neuron protein 1 0.0462 0.1364 0.1364
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0019 0.0019
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0209
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0286 0.0783
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0263 0.076 0.1518
Echinococcus multilocularis serine protein kinase ATM 0.0263 0.076 0.076
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.0071 0.0209
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0044
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.005 0.0114 0.0306
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0135 0.0371 0.1086
Brugia malayi hypothetical protein 0.0462 0.1364 0.3984
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0181 0.0181
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0019 0.005
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.005 0.0145
Onchocerca volvulus 0.0048 0.0109 0.1193
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0286 0.0568
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0467 0.138 0.4001
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0019 0.0057
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.005 0.0145
Loa Loa (eye worm) hypothetical protein 0.0462 0.1364 0.3078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0289 0.0838 0.245
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0237 0.0681 0.199
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0034 0.0065 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.1315 0.3846
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0034
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0029 0.0067
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0669 0.199 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0029 0.0029
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0034 0.0065 0.0065
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0237 0.0681 0.1945
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0002 0.0002
Echinococcus multilocularis casein kinase ii subunit alpha 0.0134 0.037 0.037
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0286 0.0835
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0012
Schistosoma mansoni lamin 0.0026 0.0042 0.008
Echinococcus multilocularis geminin 0.0165 0.0463 0.0463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0411 0.121 0.354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0418 0.1232 0.3602
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0144 0.0421
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0795 0.2374 0.2374
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.005 0.0145
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0019 0.0019
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0237 0.0681 0.5243
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0026 0.0043 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0281 0.0822
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.0532 0.1557
Loa Loa (eye worm) phosphatidylinositol 3 0.0105 0.0281 0.0635
Entamoeba histolytica serine/threonine protein kinase, putative 0.0188 0.0532 0.1509
Echinococcus multilocularis expressed conserved protein 0.008 0.0205 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0296 0.0859 0.2512
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0237 0.0681 0.199
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0283 0.0821 0.5811
Loa Loa (eye worm) calcium channel 0.0034 0.0065 0.0148
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.114 0.3419 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.002 0.0059
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0105 0.0281 0.2146
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0029 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0411 0.121 0.3539
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0041 0.0086 0.0252
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0029 0.008
Loa Loa (eye worm) hypothetical protein 0.0048 0.0109 0.0247
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0087 0.0228 0.0452
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0855 0.2554 0.7471
Leishmania major casein kinase II, putative 0.0134 0.037 0.0992
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0044
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0144 0.0421
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0158 0.0441 0.1291
Onchocerca volvulus 0.005 0.0114 0.1242
Leishmania major phosphatidylinositol kinase, putative 0.0105 0.0281 0.0755
Trypanosoma cruzi hypothetical protein, conserved 0.1136 0.3408 0.9966
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.005 0.0145
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.0665 0.1502
Trichomonas vaginalis conserved hypothetical protein 0.0256 0.0738 0.2157
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0043 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0411 0.121 0.354
Onchocerca volvulus 0.0105 0.0281 0.3064
Loa Loa (eye worm) hypothetical protein 0.0034 0.0065 0.0148
Entamoeba histolytica protein kinase rad3, putative 0.0233 0.067 0.1914
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0144 0.0898
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0855 0.2554 0.7471
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0019 0.0019
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0043 0.0124
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0134 0.037 0.0834
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0041 0.0086 0.0252
Schistosoma mansoni netrin receptor unc5 0.0014 0.0005 0.0006
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0072 0.0211
Onchocerca volvulus Serine\/threonine kinase homolog 0.0188 0.0532 0.5802
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0144 0.0421
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0105 0.0281 0.0559
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1659 0.4995 0.4995
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0105 0.0281 0.077
Brugia malayi hypothetical protein 0.0019 0.0019 0.005
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0237 0.0681 0.1359
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0029 0.0029
Giardia lamblia Kinase, CMGC GSK 0.005 0.0114 0.0331
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0237 0.0681 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0034 0.0065 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.1315 0.3846
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0019 0.0057
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0662 0.1935
Brugia malayi Casein kinase II, alpha chain 0.0134 0.037 0.1075
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0041 0.0086 0.0252
Brugia malayi follicle stimulating hormone receptor 0.0232 0.0665 0.1941
Onchocerca volvulus 0.0099 0.0261 0.2848
Plasmodium vivax hypothetical protein, conserved 0.0105 0.0281 0.4089
Plasmodium falciparum casein kinase II beta chain 0.0036 0.0071 0.0809
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0105 0.0281 0.0281
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0105 0.0281 0.4089
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.0351 0.1027
Schistosoma mansoni hypothetical protein 0.005 0.0115 0.0226
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0249 0.0728
Brugia malayi M-phase phosphoprotein, mpp8 0.0099 0.0261 0.0758
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0026 0.0043 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0019 0.0057
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0105 0.0281 0.0281
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0019 0.0019
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0237 0.0681 0.479
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0209
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0096 0.0189
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0005
Echinococcus multilocularis tumor protein p63 0.0331 0.0967 0.0967
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.041 0.0926
Schistosoma mansoni casein kinase II beta subunit 0.0036 0.0071 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0122 0.0356
Giardia lamblia Hypothetical protein 0.0105 0.0281 0.1193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0384 0.1126 0.3294
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0029 0.0067
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0188 0.0532 0.0532
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0175 0.0494 0.1439
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0423 0.1245 0.364
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0019 0.0019
Trypanosoma cruzi target of rapamycin kinase 3 0.0446 0.1316 0.3847
Schistosoma mansoni serine/threonine protein kinase 0.0188 0.0532 0.1062
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0209
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0107 0.021
Schistosoma mansoni intermediate filament proteins 0.0026 0.0042 0.008
Loa Loa (eye worm) CMGC/GSK protein kinase 0.005 0.0114 0.0257
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0019 0.0034
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0019 0.0044
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0237 0.0681 0.199
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0188 0.0532 0.1202
Leishmania major hypothetical protein, conserved 0.1241 0.3727 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0255 0.0736 0.2153
Brugia malayi Serotonin receptor 0.0457 0.1349 0.3943
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0181 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0411 0.121 0.354
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0019 0.0034
Echinococcus granulosus high voltage activated calcium channel beta 0.0085 0.022 0.022
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.005 1
Leishmania major protein kinase, putative 0.0016 0.001 0.0027
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0209
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0044
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.005 0.0114 0.0224
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0019 0.0057
Loa Loa (eye worm) hypothetical protein 0.0105 0.0281 0.0635
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0105 0.0281 0.0822
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.015 0.0419 0.0419
Trichomonas vaginalis PIKK family atypical protein kinase 0.0384 0.1126 0.3294
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0019 0.0057
Schistosoma mansoni kinase 0.0097 0.0256 0.0509
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.005 0.0351
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0105 0.0281 0.0559
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0144 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0439 0.1294 0.3784
Brugia malayi Death domain containing protein 0.0014 0.0005 0.0009
Echinococcus multilocularis protein kinase shaggy 0.005 0.0114 0.0114
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0474 0.1399 0.1399
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0025 0.0025
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0114 0.0333
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0144 0.0421
Leishmania major cytochrome p450-like protein 0.0019 0.002 0.0054
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0263 0.076 0.5367
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0047 0.0104 0.0235
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.0071 0.0209
Schistosoma mansoni voltage-gated cation channel 0.0034 0.0065 0.0127
Schistosoma mansoni single-minded 0.0048 0.0107 0.021
Mycobacterium leprae conserved hypothetical protein 0.0019 0.002 0.0708
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0423 0.1245 0.364
Brugia malayi phosphofructokinase 0.0107 0.0286 0.083
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.047 0.1387 0.2773
Echinococcus granulosus lamin dm0 0.0026 0.0042 0.0042
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0144 0.0421
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0286 0.0835
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0019 0.0019
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0025 0.0074
Leishmania major phosphatidylinositol 3-kinase, putative 0.0384 0.1126 0.3023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0044
Toxoplasma gondii hypothetical protein 0.0052 0.0122 0.0908
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0019 0.0044
Echinococcus granulosus death domain containing protein 0.0014 0.0005 0.0005
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0051 0.0051
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.0532 0.1557
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0005 0.0008
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0034 0.0065 0.0127
Loa Loa (eye worm) RecQ helicase 0.0021 0.0025 0.0057
Loa Loa (eye worm) hypothetical protein 0.0099 0.0262 0.0591
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0069 0.0069
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.002 0.0007
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.037 0.1081
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0486 0.1436 0.42
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0474 0.1399 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0318 0.0926 0.2709
Echinococcus granulosus serine protein kinase ATM 0.0263 0.076 0.076
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.037 0.1081
Loa Loa (eye worm) hypothetical protein 0.016 0.0448 0.1011
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0209
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0286 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.001 0.0029
Entamoeba histolytica hypothetical protein 0.0035 0.0069 0.0147
Echinococcus multilocularis 0.0105 0.0281 0.0281
Loa Loa (eye worm) phosphatidylinositol 3 0.0318 0.0926 0.209
Brugia malayi Protein kinase domain containing protein 0.0017 0.0015 0.0038
Loa Loa (eye worm) phosphatidylinositol 3 0.0406 0.1193 0.2692
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0144 0.0421
Echinococcus multilocularis Zinc finger, PHD finger 0.0237 0.0681 0.0681
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.015 0.0419 0.0419
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0474 0.1399 0.3755
Echinococcus granulosus expressed protein 0.0366 0.1072 0.1072
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0051 0.0114

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.757 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.593 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.285 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.223 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.111 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.098 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.096 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.01 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.924 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.695 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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