Detailed information for compound 1031917

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 719.785 | Formula: C46H33N5O4
  • H donors: 2 H acceptors: 4 LogP: 10.65 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: [O-][N+](=O)OCCOc1ccc(cc1)/C/1=c/2\cc/c(=C(/C3=N/C(=C(\c4[nH]c(/C(=C/5\N=C1C=C5)/c1ccccc1)cc4)/c1ccccc1)/C=C3)\c1ccccc1)/[nH]2
  • InChi: 1S/C46H33N5O4/c52-51(53)55-29-28-54-34-18-16-33(17-19-34)46-41-26-24-39(49-41)44(31-12-6-2-7-13-31)37-22-20-35(47-37)43(30-10-4-1-5-11-30)36-21-23-38(48-36)45(32-14-8-3-9-15-32)40-25-27-42(46)50-40/h1-27,47,50H,28-29H2/b43-35-,43-36-,44-37-,44-39-,45-38-,45-40-,46-41-,46-42-
  • InChiKey: JIMZKNCMPCFBFT-CRLDETFASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0016 0.0026 0.0046
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0026 0.0026
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0015 0.0041
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0097 0.0275
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0144 0.0934 0.0934
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.011 0.0248
Brugia malayi hypothetical protein 0.0051 0.0272 0.0745
Leishmania major alpha tubulin 0.0399 0.2755 0.779
Mycobacterium tuberculosis Probable esterase LipL 0.0116 0.074 0.14
Echinococcus granulosus tubulin alpha chain 0.0399 0.2755 0.2755
Echinococcus granulosus Tubulin beta 2C chain 0.0507 0.353 0.353
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0025 0.0085 0.0178
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0023 0.0064
Schistosoma mansoni smad1 5 8 and 0.0033 0.0145 0.013
Echinococcus granulosus calpain 0.0019 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0144 0.0934 0.2599
Trichomonas vaginalis tubulin, putative 0.0507 0.353 1
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0025 0.0085 0.0178
Trypanosoma brucei alpha tubulin 0.0399 0.2755 0.779
Entamoeba histolytica tubulin alpha chain, putative 0.0399 0.2755 0.779
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1561 0.4386
Onchocerca volvulus 0.0016 0.0026 0.0075
Loa Loa (eye worm) tubulin alpha chain 0.0399 0.2755 0.7804
Loa Loa (eye worm) pax transcription factor protein 2 0.0234 0.1583 0.4484
Loa Loa (eye worm) hypothetical protein 0.0045 0.0228 0.0646
Brugia malayi Bromodomain containing protein 0.0082 0.0496 0.1381
Brugia malayi Flap endonuclease-1 0.0026 0.0092 0.0233
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.0037 0.0105
Echinococcus multilocularis tubulin alpha chain 0.0399 0.2755 0.2755
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.047 0.1274
Onchocerca volvulus Putative neutral sphingomyelinase 0.0016 0.0023 0.0051
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0152 0.0997 0.0997
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0026 0.0011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0078 0.047 0.133
Echinococcus multilocularis cysteine protease 0.0016 0.0026 0.0026
Loa Loa (eye worm) tubulin beta-1 chain 0.0507 0.353 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0227 0.0644
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0026 0.0011
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0015 0.0041
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0188 0.0188
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0274 0.1867 0.5259
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0071 0.0415 0.0776
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0023 0.0064
Leishmania major DNA polymerase eta, putative 0.0039 0.0187 0.0469
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0188 0.0473
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0354 0.0946
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.074 0.2045
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0078 0.047 0.1274
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0078 0.047 0.5741
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0116 0.074 0.074
Leishmania major beta tubulin 0.0507 0.353 1
Echinococcus granulosus neuropeptide receptor A26 0.0455 0.3158 0.3158
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0044 0.0062
Plasmodium falciparum alpha tubulin 2 0.0399 0.2755 0.779
Leishmania major alpha tubulin 0.0399 0.2755 0.779
Giardia lamblia Beta tubulin 0.0507 0.353 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0023 0.0036
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0075 0.0447 0.1209
Schistosoma mansoni bromodomain containing protein 0.0069 0.0405 0.0391
Echinococcus granulosus Tubulin beta 2C chain 0.0507 0.353 0.353
Trypanosoma cruzi epsilon tubulin, putative 0.0286 0.1954 0.5506
Trichomonas vaginalis tubulin beta chain, putative 0.0399 0.2755 0.779
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0026 0.0075
Onchocerca volvulus Fatty acid synthase homolog 0.0045 0.0232 0.139
Brugia malayi Cathepsin L-like precursor 0.0016 0.0026 0.0046
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0255 0.0255
Brugia malayi MH2 domain containing protein 0.0015 0.0015 0.0013
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0089 0.0789
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0118 0.0103
Onchocerca volvulus 0.0234 0.1583 1
Schistosoma mansoni alpha glucosidase 0.0075 0.0447 0.0433
Onchocerca volvulus 0.0026 0.0097 0.0526
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0044 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.0997 0.0984
Leishmania major beta tubulin 0.0507 0.353 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0044 0.0062
Schistosoma mansoni tubulin subunit epsilon 0.0286 0.1954 0.1942
Leishmania major delta tubulin, putative 0.0124 0.0797 0.2208
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.01 0.0934
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.01 0.017
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0118 0.0118
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0043 0.0043
Onchocerca volvulus 0.0026 0.0097 0.0526
Echinococcus granulosus tubulin alpha chain 0.0399 0.2755 0.2755
Onchocerca volvulus 0.0044 0.0221 0.1319
Toxoplasma gondii beta tubulin 0.0507 0.353 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0048 0.0255 0.0663
Brugia malayi Pre-SET motif family protein 0.0203 0.136 0.3837
Schistosoma mansoni ap endonuclease 0.0078 0.047 0.0456
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0272 0.0711
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0354 0.0946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0011
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0044 0.0062
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0116 0.074 0.074
Brugia malayi calpain family protein 1 0.0063 0.0362 0.1
Brugia malayi PHD-finger family protein 0.0027 0.0104 0.0268
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0092 0.0198
Onchocerca volvulus 0.0016 0.0026 0.0075
Echinococcus granulosus tubulin subunit beta 0.0507 0.353 0.353
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0124 0.0797 0.2208
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.0038 0.0052
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0023 0.0064
Plasmodium falciparum tubulin gamma chain 0.0286 0.1954 0.5506
Brugia malayi MH1 domain containing protein 0.0018 0.0039 0.0084
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0145 0.0145
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0303 0.0303
Mycobacterium ulcerans beta-lactamase 0.0116 0.074 0.9254
Trypanosoma brucei tubulin delta chain 0.0124 0.0797 0.2208
Onchocerca volvulus 0.0016 0.0023 0.0051
Echinococcus granulosus tubulin delta chain 0.0124 0.0797 0.0797
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0041
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0475 0.1289
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0023 0.0064
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.0447 0.1209
Toxoplasma gondii hypothetical protein 0.0025 0.0085 0.0241
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0044 0.0062
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0026 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.0997 0.0984
Leishmania major alpha tubulin 0.0399 0.2755 0.779
Loa Loa (eye worm) hypothetical protein 0.0016 0.0026 0.0075
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0145 0.0145
Schistosoma mansoni transcription factor LCR-F1 0.0144 0.0934 0.0921
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0116 0.074 0.2075
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0272 0.0711
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0188 0.0473
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0023 0.0064
Leishmania major hypothetical protein, conserved 0.0017 0.0029 0.0019
Plasmodium falciparum alpha tubulin 1 0.0399 0.2755 0.779
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0063 0.0362 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0188 0.0473
Trichomonas vaginalis tubulin beta chain, putative 0.0399 0.2755 0.779
Schistosoma mansoni tubulin subunit beta 0.0507 0.353 0.352
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0023 0.0023
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0188 0.0507
Brugia malayi calpain 5 0.0019 0.0044 0.0097
Plasmodium vivax vivapain-2 0.0016 0.0026 0.0011
Leishmania major alpha tubulin 0.0399 0.2755 0.779
Leishmania major cathepsin L-like protease 0.0016 0.0026 0.0011
Giardia lamblia Beta tubulin 0.0507 0.353 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0075 0.0447 0.1266
Leishmania major alpha tubulin 0.0399 0.2755 0.779
Echinococcus multilocularis calpain family protein 1, d 0.0045 0.0227 0.0227
Onchocerca volvulus 0.0016 0.0023 0.0051
Loa Loa (eye worm) hypothetical protein 0.0048 0.0255 0.0723
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0054 0.0334
Leishmania major alpha tubulin 0.0399 0.2755 0.779
Trypanosoma brucei beta tubulin 0.0507 0.353 1
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0027 0.01 0.017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0152 0.0997 0.2824
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0015 0.0015
Schistosoma mansoni lamin 0.0026 0.0097 0.0083
Leishmania major kinesin, putative 0.0019 0.0044 0.0062
Trypanosoma cruzi tubulin gamma chain 0.0286 0.1954 0.5506
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0025 0.0085 0.0178
Echinococcus multilocularis lamin 0.0026 0.0097 0.0097
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0075 0.0447 0.1209
Plasmodium vivax tubulin alpha chain, putative 0.0399 0.2755 0.779
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0026 0.0011
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0026 0.0026
Echinococcus granulosus smad 0.0033 0.0145 0.0145
Schistosoma mansoni cript-related 0.0016 0.0023 0.0008
Leishmania major beta tubulin 0.0507 0.353 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0188 0.0473
Mycobacterium ulcerans cell division protein FtsZ 0.0124 0.0797 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0023 0.0036
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0078 0.047 0.047
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0048 0.0249 0.0679
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0188 0.0473
Echinococcus multilocularis tubulin alpha chain 0.0399 0.2755 0.2755
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0188 0.0473
Loa Loa (eye worm) hypothetical protein 0.0047 0.0243 0.0689
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0354 0.0946
Schistosoma mansoni hypothetical protein 0.0116 0.074 0.0727
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0023 0.0064
Trichomonas vaginalis tubulin gamma chain, putative 0.0124 0.0797 0.2208
Echinococcus granulosus tubulin alpha 0.0286 0.1954 0.1954
Echinococcus granulosus tubulin beta 1 chain 0.0507 0.353 0.353
Loa Loa (eye worm) hypothetical protein 0.0026 0.0097 0.0275
Mycobacterium tuberculosis Probable exported protein 0.0016 0.0023 0.0022
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0078 0.047 0.1274
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0368 0.2535 0.7181
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0044 0.0062
Leishmania major gamma-tubulin 0.0286 0.1954 0.5506
Entamoeba histolytica hypothetical protein 0.0025 0.0085 0.0178
Schistosoma mansoni hypothetical protein 0.0116 0.074 0.0727
Echinococcus granulosus tubulin alpha chain 0.0399 0.2755 0.2755
Loa Loa (eye worm) hypothetical protein 0.0116 0.074 0.2096
Echinococcus granulosus lysosomal alpha glucosidase 0.0339 0.2331 0.2331
Entamoeba histolytica cysteine protease, putative 0.0016 0.0026 0.0011
Leishmania major zeta tubulin, putative 0.0124 0.0797 0.2208
Plasmodium falciparum tubulin epsilon chain, putative 0.0286 0.1954 0.5506
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0044 0.0062
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0023 0.0036
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0092 0.0198
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0026 0.0011
Echinococcus granulosus zinc finger protein 0.0021 0.0063 0.0063
Echinococcus multilocularis calpain 5 0.0019 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.1413 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0241
Echinococcus multilocularis lysosomal alpha glucosidase 0.0339 0.2331 0.2331
Brugia malayi CCR4 0.0016 0.0023 0.0036
Giardia lamblia Gamma tubulin 0.0286 0.1954 0.5506
Plasmodium vivax calpain, putative 0.0019 0.0044 0.0062
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0048 0.0255 0.0663
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0303 0.0303
Brugia malayi Glycosyl hydrolases family 31 protein 0.0075 0.0447 0.1241
Trypanosoma brucei alpha tubulin, putative 0.0162 0.1066 0.2975
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0023 0.0036
Schistosoma mansoni tubulin subunit beta 0.0124 0.0797 0.0784
Echinococcus granulosus calpain A 0.0067 0.0385 0.0385
Trypanosoma brucei glycosyl hydrolase-like protein 0.0028 0.011 0.0248
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0079 0.0475 0.5806
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0025 0.0085 0.0178
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0067 0.0385 0.0385
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0023 0.0064
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0241
Echinococcus multilocularis tubulin epsilon chain 0.0286 0.1954 0.1954
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0023 0.0036
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0188 0.0473
Leishmania major alpha tubulin 0.0399 0.2755 0.779
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0188 0.0534
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0044 0.003
Toxoplasma gondii cathepsin CPL 0.0016 0.0026 0.0074
Mycobacterium leprae Probable polyketide synthase Pks1 0.0027 0.01 0.0934
Brugia malayi Cathepsin L-like precursor 0.0016 0.0026 0.0046
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0025 0.0085 0.0178
Loa Loa (eye worm) beta-tubulin 0.0507 0.353 1
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0071 0.0201
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0272 0.0771
Echinococcus multilocularis dna polymerase eta 0.0066 0.0379 0.0379
Brugia malayi Cathepsin L-like precursor 0.0016 0.0026 0.0046
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0023 0.0064
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0116 0.074 0.2073
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.011 0.0248
Mycobacterium ulcerans polyketide synthase Pks13 0.0038 0.0177 0.1941
Brugia malayi Tubulin beta chain 0.0124 0.0797 0.2236
Loa Loa (eye worm) inositol-1 0.0079 0.0475 0.1344
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0044 0.0062
Giardia lamblia Alpha-tubulin 0.0399 0.2755 0.779
Loa Loa (eye worm) hypothetical protein 0.0016 0.0023 0.0064
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0447 0.1209
Echinococcus granulosus microtubule associated protein 2 0.0679 0.4757 0.4757
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0011
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0083 0.0138
Echinococcus granulosus synaptojanin 1 0.0016 0.0023 0.0023
Brugia malayi beta-tubulin, identical 0.0507 0.353 1
Onchocerca volvulus 0.0016 0.0026 0.0075
Brugia malayi Calcitonin receptor-like protein seb-1 0.0368 0.2535 0.7173
Echinococcus granulosus lamin 0.0026 0.0097 0.0097
Trypanosoma brucei ISWI complex protein 0.0017 0.0029 0.0019
Trichomonas vaginalis tubulin alpha chain, putative 0.0162 0.1066 0.2975
Brugia malayi beta-lactamase 0.0116 0.074 0.2073
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0026 0.0011
Trichomonas vaginalis tubulin gamma chain, putative 0.0286 0.1954 0.5506
Brugia malayi MH2 domain containing protein 0.0483 0.3358 0.9513
Leishmania major cathepsin L-like protease 0.0016 0.0026 0.0011
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0368 0.2535 0.7173
Schistosoma mansoni alpha tubulin 0.0399 0.2755 0.2744
Leishmania major cathepsin L-like protease 0.0062 0.0354 0.0946
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0023 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0011
Plasmodium vivax vivapain-2 0.0016 0.0026 0.0011
Schistosoma mansoni hypothetical protein 0.0116 0.074 0.0727
Schistosoma mansoni Smad4 0.0033 0.0145 0.013
Schistosoma mansoni synaptojanin 0.0016 0.0023 0.0008
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0743 0.5214 1
Trypanosoma cruzi beta tubulin, putative 0.0507 0.353 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0144 0.0934 0.0934
Loa Loa (eye worm) tubulin alpha 2 0.0274 0.1867 0.529
Trypanosoma cruzi zeta tubulin, putative 0.0124 0.0797 0.2208
Loa Loa (eye worm) tubulin gamma chain 0.0286 0.1954 0.5535
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0255 0.1535
Onchocerca volvulus 0.0116 0.074 0.4624
Echinococcus multilocularis tubulin alpha chain 0.0399 0.2755 0.2755
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0089 0.0149
Brugia malayi intermediate filament protein 0.0026 0.0097 0.0247
Loa Loa (eye worm) hypothetical protein 0.0045 0.0227 0.0644
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0023 0.0036
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0079 0.0475 0.1289
Trypanosoma brucei beta tubulin 0.0286 0.1954 0.5506
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0102 0.0226
Brugia malayi MH1 domain containing protein 0.0033 0.0145 0.0382
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0025 0.0085 0.0178
Loa Loa (eye worm) calpain 5 0.0019 0.0044 0.0125
Trichomonas vaginalis tubulin beta chain, putative 0.0162 0.1066 0.2975
Loa Loa (eye worm) hypothetical protein 0.0051 0.0272 0.0771
Brugia malayi Glycosyl hydrolases family 31 protein 0.0339 0.2331 0.6593
Schistosoma mansoni DNA polymerase eta 0.0066 0.0379 0.0365
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.011 0.0248
Trypanosoma brucei DNA polymerase eta, putative 0.0066 0.0379 0.1017
Loa Loa (eye worm) hypothetical protein 0.0251 0.1704 0.4828
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0077 0.0218
Echinococcus granulosus calpain 5 0.0019 0.0044 0.0044
Schistosoma mansoni inositol monophosphatase 0.0079 0.0475 0.0461
Leishmania major alpha tubulin 0.0399 0.2755 0.779
Plasmodium vivax sphingomyelin synthase 2, putative 0.0025 0.0085 0.0178
Brugia malayi Sphingomyelin synthase-related 1 0.0025 0.0085 0.0213
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0354 0.0946
Echinococcus multilocularis tubulin delta chain 0.0124 0.0797 0.0797
Echinococcus granulosus neutral alpha glucosidase AB 0.0075 0.0447 0.0447
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0377 0.0377
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0054 0.0334
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0255 0.0241
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0026 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0112
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0023 0.0036
Brugia malayi Isocitrate dehydrogenase 0.0048 0.0255 0.0697
Loa Loa (eye worm) tubulin alpha-3 chain 0.0237 0.1598 0.4528
Leishmania major alpha tubulin 0.0399 0.2755 0.779
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0078 0.047 0.1274
Echinococcus multilocularis tubulin alpha 1C chain 0.0399 0.2755 0.2755
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0026 0.0011
Mycobacterium leprae Probable lipase LipE 0.0116 0.074 0.9254
Onchocerca volvulus 0.0231 0.1561 0.9861
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0255 0.0723
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0102 0.0226
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0025 0.0085 0.0178
Loa Loa (eye worm) tubulin alpha 2 0.0112 0.0711 0.2013
Mycobacterium ulcerans esterase/lipase LipP 0.0116 0.074 0.9254
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0188 0.0473
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0272 0.0711
Leishmania major beta tubulin 0.0507 0.353 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0078 0.047 0.1274
Brugia malayi ImpB/MucB/SamB family protein 0.0066 0.0379 0.1049
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0025 0.0085 0.0178
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0188 0.0473
Loa Loa (eye worm) fibroinase 0.0016 0.0026 0.0075
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0078 0.047 0.047
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.011 0.0248
Echinococcus multilocularis microtubule associated protein 2 0.0679 0.4757 0.4757
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0145 0.0409
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0077 0.0126
Mycobacterium ulcerans polyketide synthase 0.0027 0.01 0.0934
Echinococcus granulosus inositol monophosphatase 1 0.0079 0.0475 0.0475
Loa Loa (eye worm) tubulin beta chain 0.0124 0.0797 0.2258
Loa Loa (eye worm) hypothetical protein 0.0063 0.0362 0.1026
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0026 0.0075
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0025 0.0085 0.0213
Echinococcus multilocularis tubulin alpha chain 0.0399 0.2755 0.2755
Entamoeba histolytica hypothetical protein 0.0144 0.0934 0.2599
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0044 0.0062
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0044 0.0062
Entamoeba histolytica hypothetical protein 0.0025 0.0085 0.0178
Loa Loa (eye worm) BEN-1 protein 0.0507 0.353 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0475 0.1289
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0188 0.0473
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0286 0.1954 0.5535
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0092 0.0261
Leishmania major cathepsin L-like protease 0.0062 0.0354 0.0946
Echinococcus multilocularis Tubulin beta 2C chain 0.0507 0.353 0.353
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0026 0.0011
Brugia malayi alpha-tubulin 0.0399 0.2755 0.7798
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0048 0.0255 0.0663
Trypanosoma brucei antigen, putative 0.0019 0.0044 0.0062
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.088 0.6195 0.6195
Loa Loa (eye worm) tubulin beta-2A chain 0.0507 0.353 1
Plasmodium vivax sphingomyelin synthase 1, putative 0.0025 0.0085 0.0178
Schistosoma mansoni tubulin subunit beta 0.0507 0.353 0.352
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0354 0.0946
Mycobacterium ulcerans polyketide synthase 0.0025 0.0089 0.0789
Loa Loa (eye worm) hypothetical protein 0.0077 0.0463 0.1311
Loa Loa (eye worm) hypothetical protein 0.0237 0.1598 0.4528
Trypanosoma brucei tubulin gamma chain 0.0286 0.1954 0.5506
Loa Loa (eye worm) hypothetical protein 0.0016 0.0023 0.0064
Toxoplasma gondii type I fatty acid synthase, putative 0.0027 0.01 0.0283
Loa Loa (eye worm) hypothetical protein 0.0399 0.2755 0.7804
Entamoeba histolytica hypothetical protein 0.0025 0.0085 0.0178
Onchocerca volvulus 0.0023 0.0077 0.0398
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0207 0.1385 0.1385
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0079 0.0475 0.0152
Leishmania major beta tubulin 0.0507 0.353 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.074 0.2096
Echinococcus multilocularis beta tubulin 0.0507 0.353 0.353
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0025 0.0085 0.0178
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0027 0.01 0.0934
Echinococcus granulosus neutral sphingomyelinase 0.0016 0.0023 0.0023
Toxoplasma gondii exonuclease III APE 0.0078 0.047 0.133
Loa Loa (eye worm) fatty acid synthase 0.0025 0.0086 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0102 0.0226
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.011 0.0248
Echinococcus multilocularis GPCR, family 2 0.0116 0.074 0.074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0011
Brugia malayi Cell division protein ftsZ 0.0124 0.0797 0.2236
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0085 0.0178
Trichomonas vaginalis tubulin gamma chain, putative 0.0507 0.353 1
Brugia malayi MH1 domain containing protein 0.0018 0.0039 0.0084
Loa Loa (eye worm) hypothetical protein 0.0016 0.0023 0.0064
Schistosoma mansoni neutral sphingomyelinase 0.0016 0.0023 0.0008
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0015 0.0015
Trichomonas vaginalis tubulin alpha chain, putative 0.0162 0.1066 0.2975
Echinococcus multilocularis zinc finger protein 0.0021 0.0063 0.0063
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0016 0.0023 0.0023
Echinococcus granulosus tubulin alpha 3 chain 0.0399 0.2755 0.2755
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0303 0.0303
Entamoeba histolytica protein kinase, putative 0.0019 0.0044 0.0062
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0596
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0028 0.011 0.0606
Loa Loa (eye worm) alpha-tubulin 0.0399 0.2755 0.7804
Loa Loa (eye worm) hypothetical protein 0.0116 0.074 0.2096
Echinococcus granulosus Tubulin beta 2C chain 0.0507 0.353 0.353
Leishmania major cathepsin L-like protease 0.0016 0.0026 0.0011
Echinococcus multilocularis smad 0.0033 0.0145 0.0145
Plasmodium vivax tubulin gamma chain, putative 0.0286 0.1954 0.5506
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0023 0.0064
Echinococcus multilocularis deoxyribonuclease 1 2 0.0016 0.0023 0.0023
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0354 0.0946
Entamoeba histolytica hypothetical protein 0.0144 0.0934 0.2599
Echinococcus multilocularis beta tubulin 0.0507 0.353 0.353
Leishmania major cathepsin L-like protease 0.0016 0.0026 0.0011
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0447 0.1209
Loa Loa (eye worm) MH2 domain-containing protein 0.0483 0.3358 0.9514
Schistosoma mansoni tubulin subunit beta 0.0507 0.353 0.352
Schistosoma mansoni hypothetical protein 0.0023 0.0072 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0251 0.0237
Echinococcus granulosus tubulin gamma 1 chain 0.0286 0.1954 0.1954
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.011 0.0248
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0188 0.034
Trypanosoma brucei unspecified product 0.0039 0.0188 0.0473
Brugia malayi tubulin alpha-2 chain 0.0399 0.2755 0.7798
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0092 0.0092
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0272 0.0711
Loa Loa (eye worm) transcription factor SMAD2 0.0483 0.3358 0.9514
Giardia lamblia Epsilon tubulin 0.0124 0.0797 0.2208
Schistosoma mansoni tubulin subunit beta 0.0507 0.353 0.352
Brugia malayi MH1 domain containing protein 0.0033 0.0145 0.0382
Echinococcus multilocularis Tubulin beta 2C chain 0.0507 0.353 0.353
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0241
Onchocerca volvulus 0.0116 0.074 0.4624
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0097 0.0275
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0188 0.0188
Schistosoma mansoni zinc finger protein 0.0021 0.0063 0.0048
Schistosoma mansoni intermediate filament proteins 0.0026 0.0097 0.0083
Echinococcus granulosus peroxisome assembly protein 26 0.0399 0.2755 0.2755
Plasmodium vivax delta tubulin, putative 0.0124 0.0797 0.2208
Onchocerca volvulus 0.0016 0.0026 0.0075
Brugia malayi tubulin alpha chain - mouse 0.0399 0.2755 0.7798
Echinococcus multilocularis tubulin gamma 1 chain 0.0286 0.1954 0.1954
Brugia malayi Tubulin alpha chain 0.0399 0.2755 0.7798
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0447 0.1209
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0191 0.0191
Leishmania major beta tubulin 0.0507 0.353 1
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0059 0.0401
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0048 0.0255 0.0663
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0023 0.0023
Trichomonas vaginalis tubulin, putative 0.0124 0.0797 0.2208
Echinococcus multilocularis neuropeptide receptor A26 0.0455 0.3158 0.3158
Brugia malayi hypothetical protein 0.0144 0.0934 0.2626
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0044 0.0044
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0025 0.0085 0.0085
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0078 0.047 0.1274
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0044 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0188 0.0473
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0026 0.0011
Loa Loa (eye worm) hypothetical protein 0.0028 0.011 0.0311
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0015 0.0015
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0067 0.0385 0.0385
Echinococcus multilocularis hypothetical protein 0.0399 0.2755 0.2755
Onchocerca volvulus 0.0116 0.074 0.4624
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0011
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0092 0.0198
Entamoeba histolytica tubulin family protein 0.0507 0.353 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0152 0.0997 0.0997
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0026 0.0011
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0086 0.0071
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.047 0.1274
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0399 0.2755 0.779
Echinococcus granulosus beta tubulin 0.0507 0.353 0.353
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0255 0.0723
Schistosoma mansoni microtubule-associated protein tau 0.0679 0.4757 0.4749
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0025 0.0085 0.0213
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0188 0.0473
Schistosoma mansoni tubulin subunit alpha 0.0399 0.2755 0.2744
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0118 0.0333
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0089 0.0789
Brugia malayi Tubulin beta chain 0.0162 0.1066 0.3001
Trichomonas vaginalis tubulin beta chain, putative 0.0399 0.2755 0.779
Loa Loa (eye worm) hypothetical protein 0.0116 0.074 0.2096
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0023 0.0064
Schistosoma mansoni smad 0.0033 0.0145 0.013
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0188 0.2085
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0272 0.0711
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0255 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0011
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0255 0.0663
Trypanosoma brucei unspecified product 0.0027 0.0102 0.0226
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.011 0.0248
Echinococcus granulosus traf and tnf receptor associated protein 0.0016 0.0023 0.0023
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.074 0.2045
Trypanosoma brucei zeta tubulin, putative 0.0124 0.0797 0.2208
Schistosoma mansoni synaptojanin 0.0016 0.0023 0.0008
Trichomonas vaginalis tubulin beta chain, putative 0.0399 0.2755 0.779
Schistosoma mansoni flap endonuclease-1 0.0023 0.0075 0.006
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.136 0.3854
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.074 0.2045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0011
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0043 0.0028
Schistosoma mansoni alpha tubulin 0.0399 0.2755 0.2744
Trypanosoma brucei beta tubulin 0.0507 0.353 1
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0092 0.0198
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0092 0.0198
Echinococcus granulosus tubulin alpha 3 chain 0.0399 0.2755 0.2755
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.074 0.2045
Echinococcus multilocularis beta LACTamase domain containing family member 0.0116 0.074 0.074
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0188 0.0473
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0097 0.0247
Trypanosoma brucei hypothetical protein, conserved 0.0116 0.074 0.2045
Echinococcus multilocularis Tubulin alpha 1 chain 0.0399 0.2755 0.2755
Trypanosoma cruzi tubulin delta chain 0.0124 0.0797 0.2208
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0039 0.0187 0.053
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0145 0.0145
Echinococcus granulosus tubulin epsilon chain 0.0286 0.1954 0.1954
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0048 0.0255 0.0469
Trichomonas vaginalis tubulin alpha chain, putative 0.0162 0.1066 0.2975
Echinococcus multilocularis tubulin alpha 1C chain 0.0399 0.2755 0.2755
Trypanosoma brucei epsilon tubulin 0.0286 0.1954 0.5506
Echinococcus multilocularis geminin 0.1413 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0455 0.3158 0.3158
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0251 0.0251
Mycobacterium ulcerans thioesterase 0.0021 0.0059 0.0401
Echinococcus multilocularis tubulin alpha 3 chain 0.0399 0.2755 0.2755
Trypanosoma cruzi ISWI complex protein 0.0017 0.0029 0.0019
Echinococcus multilocularis tubulin alpha 3 chain 0.0399 0.2755 0.2755
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0089 0.0789
Echinococcus multilocularis calpain 0.0019 0.0044 0.0044
Loa Loa (eye worm) tubulin alpha chain 0.0399 0.2755 0.7804
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0071 0.0415 0.5036
Brugia malayi Smad1 0.0033 0.0145 0.0382
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0025 0.0085 0.0178
Brugia malayi Tubulin alpha-2 chain 0.0399 0.2755 0.7798
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0255 0.0723
Onchocerca volvulus 0.0016 0.0026 0.0075
Giardia lamblia Beta tubulin 0.0507 0.353 1
Brugia malayi Bromodomain containing protein 0.0042 0.0209 0.0566
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0067 0.0385 0.0371
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0092 0.0261
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0255 0.0241
Schistosoma mansoni inositol monophosphatase 0.0079 0.0475 0.0461
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0026 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0011
Echinococcus granulosus beta tubulin 0.0507 0.353 0.353
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0089 0.0149
Toxoplasma gondii ABC1 family protein 0.0116 0.074 0.2095
Brugia malayi Pax transcription factor protein 2 0.0234 0.1583 0.4468
Echinococcus granulosus intermediate filament protein 0.0026 0.0097 0.0097
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0044 0.003
Schistosoma mansoni tubulin subunit beta 0.0507 0.353 0.352
Leishmania major alpha tubulin 0.0399 0.2755 0.779
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0188 0.0188
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0188 0.0473
Entamoeba histolytica tubulin family protein 0.0507 0.353 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0044 0.0062
Leishmania major beta tubulin 0.0507 0.353 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0354 0.0946
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0023 0.0036
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0188 0.034
Loa Loa (eye worm) hypothetical protein 0.0063 0.0362 0.1026
Trichomonas vaginalis hypothetical protein 0.0025 0.0085 0.0178
Loa Loa (eye worm) hypothetical protein 0.0116 0.074 0.2096
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.074 0.2045
Loa Loa (eye worm) tubulin alpha 2 0.0274 0.1867 0.529
Brugia malayi mbt repeat family protein 0.0048 0.0255 0.0697
Loa Loa (eye worm) hypothetical protein 0.0368 0.2535 0.7181
Leishmania major beta tubulin 0.0507 0.353 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0316 0.0836
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0255 0.0255
Schistosoma mansoni calpain (C02 family) 0.0019 0.0044 0.003
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0027 0.01 0.017
Schistosoma mansoni zinc finger protein 0.0017 0.0029 0.0015
Loa Loa (eye worm) calpain family protein 1 0.0045 0.0227 0.0644
Schistosoma mansoni hypothetical protein 0.1413 1 1
Schistosoma mansoni spingomyelin synthetase-related 0.0025 0.0085 0.0071
Plasmodium vivax tubulin beta chain, putative 0.0507 0.353 1
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0015 0.0015
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0188 0.0174
Trypanosoma brucei inositol phosphorylceramide synthase 0.0025 0.0085 0.0178
Plasmodium vivax tubulin alpha chain, putative 0.0399 0.2755 0.779
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0377 0.0377
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0023 0.0064
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0124 0.0797 1
Loa Loa (eye worm) BEN-1 protein 0.0507 0.353 1
Schistosoma mansoni alpha tubulin 0.0399 0.2755 0.2744
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0027 0.01 0.0934
Echinococcus granulosus calpain A 0.0019 0.0044 0.0044
Mycobacterium ulcerans lipase LipD 0.0116 0.074 0.9254
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0044 0.003
Schistosoma mansoni hypothetical protein 0.031 0.2124 0.2113
Brugia malayi Tubulin alpha chain 0.0124 0.0797 0.2236
Loa Loa (eye worm) calpain family protein 1 0.0063 0.0362 0.1026
Leishmania major DNA polymerase eta, putative 0.0066 0.0379 0.1017
Schistosoma mansoni tubulin subunit delta 0.0124 0.0797 0.0784
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0089 0.0224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0354 0.0946
Leishmania major alpha glucosidase II subunit, putative 0.0075 0.0447 0.1209
Leishmania major beta tubulin 0.0507 0.353 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0255 0.0663
Echinococcus granulosus flap endonuclease 1 0.0026 0.0092 0.0092
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0475 0.1289
Echinococcus multilocularis Tubulin alpha 1 chain 0.0399 0.2755 0.2755
Plasmodium vivax hypothetical protein, conserved 0.0116 0.074 0.2045
Brugia malayi mbt repeat family protein 0.0048 0.0255 0.0697
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0059 0.0401
Schistosoma mansoni ap endonuclease 0.0078 0.047 0.0456
Loa Loa (eye worm) cysteine protease 0.0016 0.0026 0.0075
Trypanosoma brucei beta tubulin 0.0507 0.353 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0026 0.0026
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0188 0.0473
Mycobacterium tuberculosis Conserved protein 0.0116 0.074 0.14
Echinococcus multilocularis inositol monophosphatase 1 0.0079 0.0475 0.0475
Entamoeba histolytica tubulin alpha-1 chain 0.0399 0.2755 0.779
Trichomonas vaginalis tubulin, putative 0.0162 0.1066 0.2975
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0152 0.0997 0.2803
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0011
Brugia malayi beta-lactamase family protein 0.0116 0.074 0.2073
Echinococcus multilocularis Tubulin alpha 1 chain 0.0399 0.2755 0.2755
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0043 0.0043
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0086 0.0086
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0145 0.0409
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0026 0.0011
Trichomonas vaginalis tubulin epsilon chain, putative 0.0507 0.353 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0188 0.0473
Brugia malayi Tubulin alpha-2 chain 0.0399 0.2755 0.7798
Entamoeba histolytica hypothetical membrane-spanning protein 0.0025 0.0085 0.0178
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0475 0.1289
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0354 0.0946
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0092 0.0198
Loa Loa (eye worm) MBCTL1 0.0055 0.0303 0.0859
Echinococcus multilocularis cysteine protease 0.0016 0.0026 0.0026
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0025 0.0085 0.0213
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0339 0.2331 0.6603
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0026 0.0011
Plasmodium falciparum flap endonuclease 1 0.0026 0.0092 0.0198
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0475 0.1289
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0188 0.0473
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0274 0.1867 0.529
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0089 0.0789
Giardia lamblia Delta tubulin 0.0124 0.0797 0.2208
Trypanosoma brucei glucosidase, putative 0.0075 0.0447 0.1209
Brugia malayi Cathepsin L-like precursor 0.0016 0.0026 0.0046
Echinococcus multilocularis neutral alpha glucosidase AB 0.0075 0.0447 0.0447
Brugia malayi beta-lactamase family protein 0.0116 0.074 0.2073
Echinococcus granulosus tubulin alpha 1C chain 0.0399 0.2755 0.2755
Schistosoma mansoni alpha-glucosidase 0.0292 0.1994 0.1982
Brugia malayi MH2 domain containing protein 0.0033 0.0145 0.0382
Plasmodium vivax tubulin epsilon chain, putative 0.0286 0.1954 0.5506
Trichomonas vaginalis tubulin, putative 0.0162 0.1066 0.2975
Leishmania major beta tubulin 0.0507 0.353 1
Leishmania major alpha tubulin 0.0399 0.2755 0.779
Echinococcus granulosus Tubulin alpha 1 chain 0.0399 0.2755 0.2755
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0025 0.0085 0.0178
Trichomonas vaginalis tubulin gamma chain, putative 0.0286 0.1954 0.5506
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0354 0.0946
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0025 0.0085 0.0213
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0048 0.0255 0.0255
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0016 0.0023 0.0023
Schistosoma mansoni tubulin subunit beta 0.0507 0.353 0.352
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0026 0.0075
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0255 0.0255
Echinococcus multilocularis Tubulin beta 2C chain 0.0507 0.353 0.353
Trichomonas vaginalis tubulin beta chain, putative 0.0507 0.353 1
Trypanosoma cruzi epsilon tubulin, putative 0.0286 0.1954 0.5506
Giardia lamblia Alpha-tubulin 0.0399 0.2755 0.779
Echinococcus multilocularis neutral sphingomyelinase 0.0016 0.0023 0.0023
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0026 0.0012
Echinococcus granulosus Smad4 0.0033 0.0145 0.0145
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0023 0.0064
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.011 0.0283
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0072 0.0072
Echinococcus multilocularis tubulin beta 1 chain 0.0507 0.353 0.353
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0044 0.0062
Trichomonas vaginalis tubulin alpha chain, putative 0.0507 0.353 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0399 0.2755 0.779
Entamoeba histolytica calpain large subunit domain III containing protein 0.0019 0.0044 0.0062
Loa Loa (eye worm) hypothetical protein 0.0016 0.0023 0.0064
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0078 0.047 0.1274
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0255 0.0255
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0079 0.0475 0.1344
Echinococcus multilocularis tubulin subunit TubB 0.0399 0.2755 0.2755
Schistosoma mansoni nocturnin 0.0016 0.0023 0.0008
Loa Loa (eye worm) alpha-tubulin 0.0399 0.2755 0.7804
Leishmania major beta tubulin 0.0507 0.353 1
Leishmania major cathepsin L-like protease 0.0062 0.0354 0.0946
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.074 0.2045
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0152 0.0997 0.0997
Echinococcus granulosus tubulin alpha chain 0.0399 0.2755 0.2755
Trypanosoma brucei zeta tubulin 0.0124 0.0797 0.2208
Trypanosoma brucei alpha tubulin 0.0399 0.2755 0.779
Leishmania major beta tubulin 0.0507 0.353 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.074 0.2096
Echinococcus granulosus tubulin beta 4A class IVa 0.0507 0.353 0.353
Loa Loa (eye worm) isocitrate dehydrogenase 0.0048 0.0255 0.0723
Onchocerca volvulus 0.0016 0.0026 0.0075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0026 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0011
Brugia malayi Inositol-1 0.0079 0.0475 0.132
Schistosoma mansoni smad1 5 8 and 0.0033 0.0145 0.013
Schistosoma mansoni hypothetical protein 0.0116 0.074 0.0727
Leishmania major cathepsin L-like protease 0.0016 0.0026 0.0011
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0054 0.0334
Schistosoma mansoni alpha-glucosidase 0.0292 0.1994 0.1982
Loa Loa (eye worm) hypothetical protein 0.0274 0.1867 0.529
Trypanosoma brucei epsilon tubulin 0.0286 0.1954 0.5506
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0145 0.0145
Mycobacterium ulcerans hypothetical protein 0.0116 0.074 0.9254
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0089 0.0789
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0303 0.0303
Echinococcus multilocularis lamin dm0 0.0026 0.0097 0.0097
Trichomonas vaginalis tubulin beta chain, putative 0.0399 0.2755 0.779
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0067 0.0385 0.0371
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.011 0.0248
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0026 0.0011
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0251 0.0251
Leishmania major epsilon tubulin, putative 0.0286 0.1954 0.5506
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0188 0.0473
Loa Loa (eye worm) hypothetical protein 0.0066 0.0379 0.1075
Schistosoma mansoni carbon catabolite repressor protein 0.0016 0.0023 0.0008
Brugia malayi exodeoxyribonuclease III family protein 0.0078 0.047 0.1306
Trichomonas vaginalis sucrase-isomaltase, putative 0.0075 0.0447 0.1209
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0026 0.0011
Mycobacterium leprae conserved hypothetical protein 0.0116 0.074 0.9254
Loa Loa (eye worm) hypothetical protein 0.0055 0.0303 0.0859
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0044 0.0062
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.01 0.0934
Schistosoma mansoni hypothetical protein 0.0017 0.0029 0.0015
Brugia malayi Tubulin gamma chain 0.0286 0.1954 0.5522
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0354 0.0946
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0044 0.0062
Loa Loa (eye worm) tubulin alpha-2 chain 0.0399 0.2755 0.7804
Toxoplasma gondii alpha-tubulin I, putative 0.0399 0.2755 0.7804
Trypanosoma brucei epsilon tubulin 0.0286 0.1954 0.5506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0011
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0187 0.0469
Schistosoma mansoni hypothetical protein 0.0144 0.0934 0.0921
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0124 0.0797 0.2258
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0026 0.0026
Plasmodium falciparum tubulin delta chain, putative 0.0124 0.0797 0.2208
Trypanosoma brucei beta tubulin 0.0507 0.353 1
Trypanosoma brucei alpha tubulin 0.0399 0.2755 0.779
Trichomonas vaginalis conserved hypothetical protein 0.0124 0.0797 0.2208
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0471 0.3273 0.9272
Onchocerca volvulus 0.0048 0.0255 0.1535
Loa Loa (eye worm) hypothetical protein 0.0471 0.3273 0.9274
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0044 0.0062
Brugia malayi MH2 domain containing protein 0.0033 0.0145 0.0382
Treponema pallidum cell division protein FtsZ 0.0124 0.0797 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0048 0.0255 0.0255
Echinococcus granulosus Tubulin beta 2C chain 0.0507 0.353 0.353
Leishmania major beta tubulin 0.0507 0.353 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0044 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0011
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0447 0.1209
Brugia malayi calpain 7 0.0019 0.0044 0.0097
Trichomonas vaginalis tubulin beta chain, putative 0.0399 0.2755 0.779
Trypanosoma brucei alpha tubulin 0.0399 0.2755 0.779
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0044 0.0062
Echinococcus multilocularis tubulin alpha chain 0.0399 0.2755 0.2755
Trichomonas vaginalis tubulin epsilon chain, putative 0.0399 0.2755 0.779
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0594
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0241
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0026 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0188 0.0473
Brugia malayi latrophilin 2 splice variant baaae 0.0251 0.1704 0.4813
Echinococcus granulosus tubulin alpha chain 0.0399 0.2755 0.2755
Echinococcus multilocularis tubulin alpha 0.0286 0.1954 0.1954
Leishmania major beta tubulin 0.0507 0.353 1
Leishmania major DNA polymerase kappa, putative 0.0039 0.0188 0.0473
Echinococcus multilocularis Tubulin beta 2C chain 0.0507 0.353 0.353
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0255 0.0255
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0089 0.0789
Entamoeba histolytica hypothetical protein 0.0025 0.0085 0.0178
Loa Loa (eye worm) hypothetical protein 0.0048 0.0251 0.0711
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0078 0.047 0.0881
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0089 0.0149
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0507 0.353 0.353
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.0997 0.0984
Leishmania major beta tubulin 0.0507 0.353 1
Leishmania major glycosyl hydrolase-like protein 0.0028 0.011 0.0248
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0188 0.0174
Mycobacterium tuberculosis Conserved protein 0.0116 0.074 0.14
Loa Loa (eye worm) ctsf protein 0.0016 0.0026 0.0075
Leishmania major beta tubulin 0.0507 0.353 1
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0025 0.0085 0.0178
Treponema pallidum exodeoxyribonuclease (exoA) 0.0078 0.047 0.5771
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.011 0.0248
Leishmania major hypothetical protein, conserved 0.0051 0.0272 0.0711
Schistosoma mansoni hypothetical protein 0.0251 0.1704 0.1692
Loa Loa (eye worm) Smad1 0.0033 0.0145 0.0409
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0475 0.1289
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0021 0.0056 0.0086
Trypanosoma brucei kinesin, putative 0.0019 0.0044 0.0062
Schistosoma mansoni lamin 0.0026 0.0097 0.0083
Schistosoma mansoni smad1 5 8 and 0.0033 0.0145 0.013
Mycobacterium leprae cell division protein FtsZ 0.0124 0.0797 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0116 0.074 0.074
Echinococcus multilocularis Smad4 0.0033 0.0145 0.0145
Echinococcus granulosus cathepsin l1 0.0016 0.0026 0.0026
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0255 0.0255
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0026 0.0011
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0447 0.1209
Loa Loa (eye worm) tubulin beta-4 chain 0.0507 0.353 1
Onchocerca volvulus 0.0045 0.0227 0.1357
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0043 0.0028
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0044 0.0062
Trypanosoma cruzi DNA polymerase eta, putative 0.0066 0.0379 0.1017
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0188 0.0473
Brugia malayi Latrophilin receptor protein 2 0.0116 0.074 0.2075
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.074 0.0726
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0162 0.1066 0.2975
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0152 0.0997 0.0997
Echinococcus multilocularis isocitrate dehydrogenase 0.0048 0.0255 0.0255
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0044 0.0062
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0447 0.1209
Giardia lamblia DINP protein human, muc B family 0.0039 0.0188 0.0473
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0077 0.019
Echinococcus multilocularis traf and tnf receptor associated protein 0.0016 0.0023 0.0023
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0048 0.0255 0.0241
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0026 0.0026
Toxoplasma gondii beta-1 tubulin, putative 0.0507 0.353 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0207 0.1385 0.1385
Plasmodium falciparum tubulin beta chain 0.0507 0.353 1
Trypanosoma brucei unspecified product 0.0027 0.0102 0.0226
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0145 0.013
Loa Loa (eye worm) hypothetical protein 0.0195 0.13 0.3682
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0354 0.0946
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0116 0.074 0.074
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0026 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0011
Leishmania major alpha tubulin 0.0399 0.2755 0.779
Echinococcus granulosus alpha tubulin 0.0399 0.2755 0.2755
Trichomonas vaginalis maltase-glucoamylase, putative 0.0075 0.0447 0.1209
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0354 0.0946
Trichomonas vaginalis inositol monophosphatase, putative 0.0079 0.0475 0.1289
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0354 0.0946
Echinococcus granulosus sphingomyelin synthase protein 1 0.0025 0.0085 0.0085
Loa Loa (eye worm) beta-lactamase 0.0116 0.074 0.2096
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0255 0.0241
Brugia malayi Tubulin beta-1 chain 0.0507 0.353 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0116 0.074 0.14
Brugia malayi Pre-SET motif family protein 0.0029 0.0118 0.0306
Onchocerca volvulus 0.0016 0.0026 0.0075
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0116 0.074 0.14
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0038 0.0177 0.0319
Echinococcus granulosus Tubulin alpha 1 chain 0.0399 0.2755 0.2755
Schistosoma mansoni hypothetical protein 0.0023 0.0071 0.0056
Echinococcus multilocularis musashi 0.0026 0.0097 0.0097
Mycobacterium tuberculosis Probable lipase LipE 0.0116 0.074 0.14
Plasmodium vivax SET domain protein, putative 0.0029 0.0118 0.0271
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0237 0.1598 0.4492
Echinococcus multilocularis Tubulin beta 2C chain 0.0507 0.353 0.353
Onchocerca volvulus 0.0162 0.1066 0.6706
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.011 0.0248
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.047 0.1274
Loa Loa (eye worm) latrophilin receptor protein 2 0.0116 0.074 0.2097
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0016 0.0023 0.0008
Mycobacterium leprae Polyketide synthase Pks13 0.0038 0.0177 0.1941
Trypanosoma cruzi zeta tubulin, putative 0.0124 0.0797 0.2208
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0116 0.074 0.2096
Loa Loa (eye worm) nuclear factor I 0.0018 0.0039 0.0112
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.074 0.2045
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0191 0.0191
Schistosoma mansoni tubulin subunit alpha 0.0399 0.2755 0.2744
Echinococcus multilocularis peroxisome assembly protein 26 0.0399 0.2755 0.2755
Echinococcus granulosus Tubulin beta 2C chain 0.0507 0.353 0.353
Entamoeba histolytica hypothetical protein 0.0025 0.0085 0.0178
Echinococcus granulosus GPCR family 2 0.0116 0.074 0.074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0354 0.0946
Trypanosoma cruzi alpha tubulin, putative 0.0399 0.2755 0.779
Schistosoma mansoni tubulin subunit alpha 0.0124 0.0797 0.0784
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0188 0.0473
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0116 0.074 0.9254
Toxoplasma gondii beta-tubulin, putative 0.0507 0.353 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0118 0.0103
Echinococcus multilocularis hypothetical protein 0.0019 0.0044 0.0044
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.011 0.011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.074 0.0726
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0303 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0011
Mycobacterium tuberculosis Probable hydrolase 0.0116 0.074 0.14
Echinococcus multilocularis synaptojanin 1 0.0016 0.0023 0.0023
Echinococcus granulosus lamin dm0 0.0026 0.0097 0.0097
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0075 0.0447 0.1266
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0195 0.13 0.3664
Echinococcus granulosus Tubulin alpha 1 chain 0.0399 0.2755 0.2755
Onchocerca volvulus 0.0029 0.0118 0.0657
Echinococcus multilocularis calpain A 0.0067 0.0385 0.0385
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0241
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0026 0.0012
Entamoeba histolytica hypothetical protein 0.0144 0.0934 0.2599
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0116 0.074 0.14
Echinococcus granulosus dna polymerase eta 0.0066 0.0379 0.0379
Echinococcus multilocularis lysosomal alpha glucosidase 0.0339 0.2331 0.2331
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0059 0.0091
Echinococcus multilocularis tubulin subunit beta 0.0507 0.353 0.353
Toxoplasma gondii alpha tubulin TUBA1 0.0399 0.2755 0.7804
Leishmania major beta tubulin 0.0507 0.353 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0251 0.0237
Brugia malayi isocitrate dehydrogenase 0.0048 0.0255 0.0697
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0038 0.0177 0.0319
Entamoeba histolytica tubulin gamma chain 0.0286 0.1954 0.5506
Loa Loa (eye worm) hypothetical protein 0.0116 0.074 0.2097
Trichomonas vaginalis tubulin alpha chain, putative 0.0286 0.1954 0.5506
Leishmania major beta tubulin 0.0507 0.353 1
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0015 0.0013
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0083 0.0138
Trichomonas vaginalis esterase, putative 0.0116 0.074 0.2045
Echinococcus granulosus neuropeptide s receptor 0.0455 0.3158 0.3158
Schistosoma mansoni tubulin subunit alpha 0.0399 0.2755 0.2744
Echinococcus granulosus dna polymerase kappa 0.0039 0.0188 0.0188
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0116 0.074 0.074
Trypanosoma cruzi kinesin, putative 0.0019 0.0044 0.0062
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0044 0.0062
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0016 0.0023 0.0064
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0048 0.0135
Trypanosoma cruzi kinesin, putative 0.0019 0.0044 0.0062
Echinococcus granulosus tubulin alpha 1C chain 0.0399 0.2755 0.2755
Mycobacterium tuberculosis Probable lipase LipD 0.0116 0.074 0.14
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.001 0.0028
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0255 0.0663
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0272 0.0711
Brugia malayi Cathepsin L-like precursor 0.0016 0.0026 0.0046
Trypanosoma cruzi ISWI complex protein 0.0017 0.0029 0.0019
Loa Loa (eye worm) calpain 0.0019 0.0044 0.0125
Loa Loa (eye worm) tubulin beta chain 0.0507 0.353 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.0447 0.1209
Brugia malayi hypothetical protein 0.0033 0.0144 0.038
Leishmania major hypothetical protein, conserved 0.0116 0.074 0.2045
Echinococcus granulosus tubulin subunit TubB 0.0399 0.2755 0.2755
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0124 0.0797 0.2258
Mycobacterium tuberculosis Conserved protein 0.0116 0.074 0.14
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0447 0.1209
Brugia malayi calpain family protein 1 0.0063 0.0362 0.1
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0259 0.0675
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0026 0.0073
Trichomonas vaginalis tubulin epsilon chain, putative 0.0507 0.353 1
Onchocerca volvulus 0.0196 0.131 0.826
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0026 0.0011
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.047 0.1274
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0092 0.0198
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0026 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0189 0.1262 0.3533
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0086 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0124 0.0797 0.2208
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0072 0.0072
Trypanosoma cruzi tubulin delta chain 0.0124 0.0797 0.2208
Schistosoma mansoni tubulin subunit gamma 0.0286 0.1954 0.1942
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0303 0.0833
Trichomonas vaginalis tubulin epsilon chain, putative 0.0124 0.0797 0.2208
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0188 0.2085
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0025 0.0085 0.0178
Mycobacterium tuberculosis Cell division protein FtsZ 0.0124 0.0797 0.151
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.011 0.0248

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.8 uM Cytotoxicity against human Bel7402 after 72 hrs by MTT assay ChEMBL. 19233650
IC50 (functional) = 8.7 uM Cytotoxicity against human MCF7 after 72 hrs by MTT assay ChEMBL. 19233650

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19233650

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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