Detailed information for compound 1284663

Basic information

Technical information
  • TDR Targets ID: 1284663
  • Name: N-(2,3-dihydro-1,4-benzodioxin-7-yl)-6-[(3-me thoxyphenyl)methyl]-7,8-dihydro-5H-pyrido[4,3 -d]pyrimidin-2-amine
  • MW: 404.462 | Formula: C23H24N4O3
  • H donors: 1 H acceptors: 2 LogP: 3.17 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)CN1CCc2c(C1)cnc(n2)Nc1ccc2c(c1)OCCO2
  • InChi: 1S/C23H24N4O3/c1-28-19-4-2-3-16(11-19)14-27-8-7-20-17(15-27)13-24-23(26-20)25-18-5-6-21-22(12-18)30-10-9-29-21/h2-6,11-13H,7-10,14-15H2,1H3,(H,24,25,26)
  • InChiKey: AUFUKFJZTCPKFF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,3-dihydro-1,4-benzodioxin-7-yl-[6-(3-methoxybenzyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]amine
  • G421-0544
  • NCGC00131180-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0205 0.135
Echinococcus multilocularis calpain 0.0019 0.0045 0.0042
Brugia malayi nuclear hormone receptor 0.0012 0.0003 0.0006
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0212 0.0209
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0112 0.0555 0.3652
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0006
Echinococcus granulosus calpain 5 0.0019 0.0045 0.006
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0026 0.0035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0031 0.0202
Echinococcus granulosus calpain A 0.0068 0.0316 0.042
Loa Loa (eye worm) fatty acid synthase 0.0027 0.0089 0.0175
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0153 0.0783 0.1463
Brugia malayi Cathepsin L-like precursor 0.0017 0.0031 0.0061
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0115 0.0573 0.0571
Schistosoma mansoni alpha-glucosidase 0.0287 0.1522 0.2025
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0543
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0006
Echinococcus multilocularis beta LACTamase domain containing family member 0.0153 0.0783 0.078
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0977 0.5335 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0363 0.1946 0.3848
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0281 0.0374
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0065 0.0429
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0003 0.0006
Schistosoma mansoni ap endonuclease 0.0079 0.0377 0.0501
Loa Loa (eye worm) hypothetical protein 0.0016 0.0026 0.0052
Trichomonas vaginalis inositol monophosphatase, putative 0.0012 0.0003 0.0017
Leishmania major cathepsin L-like protease 0.0064 0.0291 0.3702
Loa Loa (eye worm) hypothetical protein 0.0153 0.0783 0.1548
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0028 0.0091 0.1131
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0003 0.0004
Echinococcus granulosus tar DNA binding protein 0.0062 0.0281 0.0374
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0065 0.0803
Trichomonas vaginalis maltase-glucoamylase, putative 0.0074 0.0346 0.2281
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0031 0.0202
Loa Loa (eye worm) RNA binding protein 0.0062 0.0281 0.0556
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0153 0.0783 0.1548
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0031 0.0202
Echinococcus granulosus traf and tnf receptor associated protein 0.0016 0.0026 0.0035
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.009 0.0593
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0281 0.0279
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0018 0.0039 0.0467
Mycobacterium tuberculosis Probable lipase LipD 0.0153 0.0783 0.1463
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0031 0.0202
Loa Loa (eye worm) hypothetical protein 0.0047 0.02 0.0395
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0028 0.0091 0.1131
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0045 0.006
Echinococcus granulosus zinc finger protein 0.0023 0.0064 0.0085
Mycobacterium tuberculosis Probable thioesterase TesA 0.0023 0.0065 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0031 0.0202
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0006
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0926 0.5057 1
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0016 0.0026 0.0307
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0016 0.0026 0.0478
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.009 0.0593
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0003 0.0004
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0026 0.0307
Onchocerca volvulus 0.0016 0.0026 0.0175
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0026 0.0478
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0291 0.3702
Brugia malayi Importin beta-1 subunit 0.0028 0.0095 0.0188
Schistosoma mansoni hypothetical protein 0.0072 0.0333 0.0443
Schistosoma mansoni zinc finger protein 0.0018 0.0036 0.0048
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.025 0.0494
Brugia malayi nuclear receptor NHR-88 0.0012 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0026 0.0052
Loa Loa (eye worm) calpain 0.0019 0.0045 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0291 0.3702
Trypanosoma brucei antigen, putative 0.0019 0.0045 0.0543
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0028 0.0091 0.1131
Brugia malayi Inositol monophosphatase family protein 0.0012 0.0003 0.0005
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0003 0.0004
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0003 0.0006
Loa Loa (eye worm) beta-lactamase 0.0153 0.0783 0.1548
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0022 0.0061 0.0748
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0048 0.0205 0.5098
Leishmania major kinesin, putative 0.0019 0.0045 0.0543
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0031 0.0028
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0045 0.0543
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0028 0.0091 0.0165
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0052 0.0228 0.045
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0045 0.0543
Schistosoma mansoni bromodomain containing protein 0.0074 0.0344 0.0458
Schistosoma mansoni hypothetical protein 0.0115 0.0573 0.0762
Mycobacterium leprae conserved hypothetical protein 0.0153 0.0783 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0297 0.0588
Leishmania major hypothetical protein, conserved 0.0016 0.0026 0.0307
Loa Loa (eye worm) hypothetical protein 0.0926 0.5057 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0041 0.0166 0.0307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0291 0.3702
Brugia malayi mbt repeat family protein 0.005 0.0212 0.0419
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1326 0.2623
Loa Loa (eye worm) hypothetical protein 0.0065 0.0297 0.0588
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0048 0.0205 0.2596
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0482 0.0953
Schistosoma mansoni importin beta-1 0.0028 0.0095 0.0126
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0031 0.0361
Brugia malayi Cathepsin L-like precursor 0.0017 0.0031 0.0061
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0047
Schistosoma mansoni hypothetical protein 0.0893 0.4872 0.6479
Echinococcus multilocularis zinc finger protein 0.0023 0.0064 0.0061
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0079 0.0377 0.0374
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0003 0.0004
Onchocerca volvulus 0.005 0.0212 0.1395
Mycobacterium ulcerans lipase LipD 0.0153 0.0783 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0026 0.0052
Brugia malayi Bromodomain containing protein 0.0087 0.042 0.083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0031 0.0202
Echinococcus multilocularis geminin 0.0893 0.4872 0.4871
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0003 0.0006
Onchocerca volvulus 0.0017 0.0031 0.0202
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0079 0.0377 0.4797
Loa Loa (eye worm) hypothetical protein 0.0046 0.019 0.0377
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0003 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.0247 0.0328
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0026 0.0052
Leishmania major cathepsin L-like protease 0.0017 0.0031 0.0361
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0026 0.0052
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0026 0.0478
Leishmania major cathepsin L-like protease 0.0017 0.0031 0.0361
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0031 0.0028
Mycobacterium ulcerans polyketide synthase Pks9 0.0018 0.0039 0.0467
Giardia lamblia hypothetical protein 0.0016 0.0026 0.0641
Onchocerca volvulus 0.0048 0.0204 0.1343
Brugia malayi Pre-SET motif family protein 0.0036 0.0137 0.0271
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0482 0.048
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0281 0.0556
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.009 0.1122
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0079 0.0377 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0003 0.0004
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0003 0.0019
Loa Loa (eye worm) latrophilin receptor protein 2 0.0115 0.0573 0.1134
Loa Loa (eye worm) hypothetical protein 0.0082 0.0392 0.0776
Loa Loa (eye worm) hypothetical protein 0.0048 0.0205 0.0406
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0211 0.1106 0.1471
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0023 0.0063 0.0113
Schistosoma mansoni nocturnin 0.0016 0.0026 0.0035
Echinococcus granulosus inositol monophosphatase 1 0.0112 0.0555 0.0737
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0291 0.3702
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0031 0.0202
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0048 0.0205 0.2596
Onchocerca volvulus 0.0026 0.0081 0.0532
Schistosoma mansoni pap-inositol-14-phosphatase 0.0012 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0048 0.0205 0.3698
Toxoplasma gondii ABC1 family protein 0.0153 0.0783 1
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0016 0.0026 0.0307
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0031 0.0202
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0095 0.1183
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0026 0.0175
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0115 0.0573 0.0571
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.002 0.0048 0.0085
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0184 0.0952 0.1883
Toxoplasma gondii hypothetical protein 0.0048 0.0205 0.2596
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0543
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0291 0.3702
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0026 0.0307
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0053 0.0106
Trypanosoma brucei hypothetical protein, conserved 0.0153 0.0783 1
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0216 0.2732
Echinococcus multilocularis cysteine protease 0.0017 0.0031 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0153 0.0783 0.1548
Trypanosoma cruzi hypothetical protein, conserved 0.0153 0.0783 1
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0026 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0031 0.0202
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0016 0.0026 0.0035
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0333 0.0443
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0016 0.0026 0.0052
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0482 0.0953
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0005
Onchocerca volvulus 0.0153 0.0783 0.5155
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0048 0.0205 0.0406
Mycobacterium tuberculosis Probable hydrolase 0.0153 0.0783 0.1463
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0026 0.0307
Loa Loa (eye worm) hypothetical protein 0.0153 0.0783 0.1548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0031 0.0202
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0016 0.0026 0.0035
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0026 0.0478
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0029 0.01 0.1253
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0026 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0003 0.0006
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0029 0.01 0.0183
Brugia malayi Glycosyl hydrolases family 31 protein 0.0333 0.1779 0.3518
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0003 0.0006
Schistosoma mansoni zinc finger protein 0.0023 0.0064 0.0085
Schistosoma mansoni hypothetical protein 0.0317 0.1692 0.225
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0003 0.0006
Entamoeba histolytica hypothetical protein 0.0048 0.0205 0.3698
Mycobacterium ulcerans Type I modular polyketide synthase 0.0028 0.0091 0.1131
Echinococcus granulosus neutral sphingomyelinase 0.0016 0.0026 0.0035
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0026 0.0478
Brugia malayi ecdysteroid receptor 0.0012 0.0003 0.0006
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0056 0.0247 0.0244
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0112 0.0555 0.3652
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0045 0.0543
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0031 0.0041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0482 0.0641
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0016 0.0026 0.0307
Echinococcus multilocularis snurportin 1 0.0303 0.1613 0.1611
Schistosoma mansoni synaptojanin 0.0016 0.0026 0.0035
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0026 0.0478
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0045 0.0543
Toxoplasma gondii type I fatty acid synthase, putative 0.0029 0.01 0.1253
Schistosoma mansoni calpain (C02 family) 0.0019 0.0045 0.006
Schistosoma mansoni survival motor neuron protein 0.0047 0.0199 0.0264
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0016 0.0026 0.0307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0291 0.3702
Loa Loa (eye worm) hypothetical protein 0.0048 0.0205 0.0406
Schistosoma mansoni spingomyelin synthetase-related 0.0048 0.0205 0.0273
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0048 0.0205 0.135
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0212 0.0282
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0003 0.0006
Leishmania major GTP-binding protein, putative 0.0021 0.0053 0.0652
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.009 0.0593
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0016 0.0026 0.0307
Entamoeba histolytica hypothetical protein 0.0048 0.0205 0.3698
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0346 0.2281
Trypanosoma cruzi ISWI complex protein 0.0018 0.0036 0.0432
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0029 0.01 0.1253
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0053 0.0652
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0346 0.2281
Loa Loa (eye worm) hypothetical protein 0.0231 0.1216 0.2406
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0074 0.0346 0.2281
Schistosoma mansoni hypothetical protein 0.0248 0.1311 0.1743
Mycobacterium ulcerans esterase/lipase LipP 0.0153 0.0783 1
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0031 0.0061
Leishmania major cathepsin L-like protease 0.0017 0.0031 0.0361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0291 0.3702
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0074 0.0346 0.4408
Loa Loa (eye worm) hypothetical protein 0.0153 0.0783 0.1548
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0047 0.0045
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0026 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0003 0.0006
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0212 0.0419
Schistosoma mansoni ran 0.0021 0.0053 0.0071
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0026 0.0478
Brugia malayi TAR-binding protein 0.0062 0.0281 0.0556
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0026 0.0052
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0016 0.0026 0.0307
Brugia malayi calpain family protein 1 0.0065 0.0297 0.0588
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0026 0.0478
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0048 0.0205 0.0406
Schistosoma mansoni hypothetical protein 0.0893 0.4872 0.6479
Brugia malayi Cathepsin L-like precursor 0.0017 0.0031 0.0061
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0482 0.0641
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0016 0.0026 0.0175
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0031 0.0202
Mycobacterium tuberculosis Conserved protein 0.0153 0.0783 0.1463
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0018 0.0037 0.0443
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0045 0.0042
Mycobacterium ulcerans thioesterase 0.0023 0.0065 0.0804
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0261 0.3309
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0016 0.0026 0.0175
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.009 0.1624
Toxoplasma gondii cathepsin CPL 0.0017 0.0031 0.0361
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0281 0.0556
Schistosoma mansoni alpha glucosidase 0.0074 0.0346 0.0461
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0212 0.0282
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0079 0.0377 0.6794
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0083 0.008
Plasmodium vivax hypothetical protein, conserved 0.0153 0.0783 1
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0023 0.0065 0.0804
Plasmodium vivax vivapain-2 0.0017 0.0031 0.0055
Leishmania major cathepsin L-like protease 0.0064 0.0291 0.3702
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0031 0.0202
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0053 0.0051
Echinococcus granulosus calpain 0.0019 0.0045 0.006
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0031 0.0119
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0026 0.0052
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0137 0.0135
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0083 0.011
Echinococcus multilocularis calpain family protein 1, d 0.0046 0.019 0.0188
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0026 0.0081 0.016
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0016 0.0026 0.0307
Schistosoma mansoni hypothetical protein 0.0018 0.0036 0.0048
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0016 0.0026 0.0175
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0212 0.0209
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0115 0.0573 0.0762
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0184 0.0952 0.1883
Echinococcus multilocularis neutral alpha glucosidase AB 0.0074 0.0346 0.0344
Plasmodium falciparum importin beta, putative 0.0028 0.0095 0.1951
Schistosoma mansoni synaptojanin 0.0016 0.0026 0.0035
Trichomonas vaginalis penicillin-binding protein, putative 0.0153 0.0783 0.5155
Onchocerca volvulus Fatty acid synthase homolog 0.005 0.0213 0.1406
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0003 0.0006
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0281 0.0556
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0079 0.0377 0.0702
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0079 0.0377 0.4797
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0003 0.0004
Brugia malayi calpain 7 0.0019 0.0045 0.0089
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0079 0.0377 0.4797
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0026 0.0307
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0321 0.0428
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0005
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0031 0.0119
Brugia malayi Inositol monophosphatase family protein 0.0012 0.0003 0.0005
Mycobacterium tuberculosis Probable lipase LipE 0.0153 0.0783 0.1463
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0012 0.0003 0.0003
Trichomonas vaginalis Phospholipase C precursor, putative 0.0016 0.0026 0.0175
Trypanosoma brucei kinesin, putative 0.0019 0.0045 0.0543
Loa Loa (eye worm) fibroinase 0.0017 0.0031 0.0061
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0079 0.0377 0.4797
Echinococcus multilocularis synaptojanin 1 0.0016 0.0026 0.0024
Mycobacterium ulcerans Type I modular polyketide synthase 0.0028 0.0091 0.1131
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0048 0.0205 0.0203
Echinococcus granulosus synaptojanin 1 0.0016 0.0026 0.0035
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0095 0.1183
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0003 0.0006
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0061 0.0081
Echinococcus granulosus geminin 0.0893 0.4872 0.6479
Trichomonas vaginalis inositol monophosphatase, putative 0.0012 0.0003 0.0017
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0074 0.0346 0.2281
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0153 0.0783 0.1463
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0068 0.0316 0.042
Echinococcus granulosus inositol monophosphatase 0.0012 0.0003 0.0003
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0346 0.2281
Schistosoma mansoni hypothetical protein 0.0024 0.007 0.0094
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0016 0.0026 0.0175
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0169 0.0224
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0115 0.0573 0.0762
Entamoeba histolytica hypothetical protein 0.0072 0.0333 0.6008
Schistosoma mansoni hypothetical protein 0.0047 0.0199 0.0264
Echinococcus multilocularis microtubule associated protein 2 0.1372 0.752 0.7519
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0003 0.0006
Loa Loa (eye worm) acyl carrier protein 0.0013 0.0008 0.0016
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0321 0.0319
Entamoeba histolytica hypothetical membrane-spanning protein 0.0048 0.0205 0.3698
Trypanosoma brucei glucosidase, putative 0.0074 0.0346 0.4408
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0012 0.0003 0.0017
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0068 0.0316 0.042
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0048 0.0205 0.2596
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0053 0.0652
Loa Loa (eye worm) hypothetical protein 0.0056 0.0247 0.0488
Trypanosoma cruzi ISWI complex protein 0.0018 0.0036 0.0432
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0031 0.0361
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0028 0.0091 0.018
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0016 0.0026 0.0307
Toxoplasma gondii type I fatty acid synthase, putative 0.002 0.0047 0.0566
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0079 0.0377 0.0745
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0053 0.0356
Brugia malayi CCR4 0.0016 0.0026 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.0925 0.6089
Leishmania major endonuclease/exonuclease protein-like protein 0.0016 0.0026 0.0307
Leishmania major cathepsin L-like protease 0.0017 0.0031 0.0361
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0065 0.0429
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0048 0.0205 0.0406
Echinococcus multilocularis GPCR, family 2 0.0115 0.0573 0.0571
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0031 0.0202
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0543
Plasmodium vivax vivapain-2 0.0017 0.0031 0.0055
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0031 0.0119
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0137 0.1725
Brugia malayi latrophilin 2 splice variant baaae 0.0248 0.1311 0.2592
Echinococcus multilocularis calpain A 0.0068 0.0316 0.0313
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0048 0.0205 0.135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0031 0.0202
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0016 0.0026 0.0024
Brugia malayi beta-lactamase 0.0153 0.0783 0.1548
Schistosoma mansoni cript-related 0.0016 0.0026 0.0035
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0074 0.0346 0.0685
Plasmodium vivax calpain, putative 0.0019 0.0045 0.0243
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0074 0.0346 0.6246
Loa Loa (eye worm) hypothetical protein 0.0363 0.1946 0.3848
Echinococcus granulosus neutral alpha glucosidase AB 0.0074 0.0346 0.0461
Brugia malayi Cathepsin L-like precursor 0.0017 0.0031 0.0061
Onchocerca volvulus 0.0153 0.0783 0.5155
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0053 0.0768
Brugia malayi Latrophilin receptor protein 2 0.0115 0.0573 0.1134
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0026 0.0052
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.1216 0.1214
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0031 0.0061
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0006
Leishmania major cathepsin L-like protease 0.0064 0.0291 0.3702
Loa Loa (eye worm) hypothetical protein 0.005 0.0212 0.0419
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0026 0.0175
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0212 0.0282
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.0247 0.0328
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0041 0.0166 0.0307
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0053 0.136
Onchocerca volvulus 0.0017 0.0031 0.0202
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0031 0.0202
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0003 0.0004
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0016 0.0026 0.0478
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0281 0.0374
Echinococcus granulosus beta LACTamase domain containing family member 0.0153 0.0783 0.1041
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0153 0.0783 0.1041
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0031 0.0028
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.025 0.0247
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0543
Leishmania major pantothenate kinase subunit, putative 0.0016 0.0026 0.0307
Loa Loa (eye worm) hypothetical protein 0.0046 0.0195 0.0385
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0212 0.0282
Echinococcus granulosus snurportin 1 0.0303 0.1613 0.2146
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0029 0.01 0.1253
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0026 0.0052
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0026 0.0052
Brugia malayi beta-lactamase family protein 0.0153 0.0783 0.1548
Brugia malayi RNA binding protein 0.0062 0.0281 0.0556
Loa Loa (eye worm) hypothetical protein 0.0016 0.0026 0.0052
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0018 0.0039 0.0467
Schistosoma mansoni coup transcription factor 0.0012 0.0003 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0081 0.016
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0153 0.0783 0.1548
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0027 0.0086 0.0157
Onchocerca volvulus 0.0016 0.0026 0.0175
Leishmania major hypothetical protein, conserved 0.0016 0.0026 0.0307
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0015 0.0162
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0003 0.0004
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0026 0.0307
Onchocerca volvulus 0.0047 0.0199 0.1309
Entamoeba histolytica hypothetical protein 0.0048 0.0205 0.3698
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0363 0.1946 0.3848
Onchocerca volvulus 0.0017 0.0031 0.0202
Schistosoma mansoni ran 0.0021 0.0053 0.0071
Onchocerca volvulus 0.0017 0.0031 0.0202
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0028 0.009 0.0593
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0045 0.0543
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0026 0.0307
Mycobacterium tuberculosis Conserved protein 0.0153 0.0783 0.1463
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0153 0.0783 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0053 0.0963
Schistosoma mansoni myo inositol monophosphatase 0.0012 0.0003 0.0003
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0079 0.0377 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0031 0.0041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0482 0.048
Trichomonas vaginalis ap endonuclease, putative 0.0079 0.0377 0.2481
Trichomonas vaginalis sucrase-isomaltase, putative 0.0074 0.0346 0.2281
Loa Loa (eye worm) hypothetical protein 0.0115 0.0573 0.1134
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0281 0.0374
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0031 0.0202
Schistosoma mansoni hypothetical protein 0.0303 0.1613 0.2146
Echinococcus multilocularis neutral sphingomyelinase 0.0016 0.0026 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0291 0.3702
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0003 0.0006
Loa Loa (eye worm) cysteine protease 0.0017 0.0031 0.0061
Loa Loa (eye worm) hypothetical protein 0.0248 0.1311 0.2592
Mycobacterium ulcerans thioesterase TesA 0.0023 0.0065 0.0804
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0003 0.0004
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0031 0.0041
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.0012 0.0003 0.0017
Onchocerca volvulus 0.0017 0.0031 0.0202
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0068 0.0316 0.0313
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0026 0.0307
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0045 0.0543
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0026 0.0307
Echinococcus multilocularis calpain 5 0.0019 0.0045 0.0042
Mycobacterium ulcerans Type I modular polyketide synthase 0.0028 0.0091 0.1131
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0053 0.0652
Entamoeba histolytica hypothetical protein 0.0023 0.0065 0.1175
Trypanosoma cruzi kinesin, putative 0.0019 0.0045 0.0543
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0026 0.0478
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0291 0.3702
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0026 0.0052
Entamoeba histolytica hypothetical protein 0.0072 0.0333 0.6008
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.0555 0.7076
Toxoplasma gondii exonuclease III APE 0.0079 0.0377 0.4797
Entamoeba histolytica hypothetical protein 0.0048 0.0205 0.3698
Brugia malayi mbt repeat family protein 0.005 0.0212 0.0419
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0153 0.0783 0.1041
Mycobacterium ulcerans hypothetical protein 0.0153 0.0783 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0031 0.0202
Echinococcus multilocularis lysosomal alpha glucosidase 0.0333 0.1779 0.1777
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0048 0.0205 0.2596
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0079 0.0377 0.4797
Loa Loa (eye worm) hypothetical protein 0.0048 0.0205 0.0406
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0031 0.0202
Plasmodium vivax sphingomyelin synthase 1, putative 0.0048 0.0205 0.2361
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0026 0.0307
Mycobacterium tuberculosis Conserved protein 0.0153 0.0783 0.1463
Leishmania major RNA-editing complex protein MP100, putative 0.0016 0.0026 0.0307
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0022 0.0061 0.0748
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0482 0.0641
Mycobacterium ulcerans polyketide synthase 0.0029 0.01 0.1253
Loa Loa (eye worm) ctsf protein 0.0017 0.0031 0.0061
Echinococcus granulosus calpain A 0.0019 0.0045 0.006
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0022 0.0061 0.0748
Brugia malayi Sphingomyelin synthase-related 1 0.0048 0.0205 0.0406
Leishmania major glycosyl hydrolase-like protein 0.0028 0.009 0.1122
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.025 0.0332
Mycobacterium ulcerans beta-lactamase 0.0153 0.0783 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.025 0.0494
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0065 0.0429
Schistosoma mansoni neutral sphingomyelinase 0.0016 0.0026 0.0035
Plasmodium vivax sphingomyelin synthase 2, putative 0.0048 0.0205 0.2361
Trypanosoma brucei inositol phosphorylceramide synthase 0.0048 0.0205 0.2596
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0003 0.0006
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0003 0.0004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0003 0.0004
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0048 0.0205 0.2596
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0031 0.0202
Trypanosoma cruzi kinesin, putative 0.0019 0.0045 0.0543
Brugia malayi calpain family protein 1 0.0065 0.0297 0.0588
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0016 0.0025 0.0042
Loa Loa (eye worm) hypothetical protein 0.0048 0.0205 0.0406
Onchocerca volvulus 0.0153 0.0783 0.5155
Leishmania major alpha glucosidase II subunit, putative 0.0074 0.0346 0.4408
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0068 0.0316 0.042
Onchocerca volvulus 0.0036 0.0137 0.0903
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0026 0.0307
Brugia malayi Cathepsin L-like precursor 0.0017 0.0031 0.0061
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0031 0.0028
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.0555 0.7076
Schistosoma mansoni alpha-glucosidase 0.0287 0.1522 0.2025
Loa Loa (eye worm) calpain family protein 1 0.0065 0.0297 0.0588
Trichomonas vaginalis D-aminoacylase, putative 0.0153 0.0783 0.5155
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0112 0.0555 0.7076
Trypanosoma cruzi hypothetical protein, conserved 0.0153 0.0783 1
Plasmodium vivax SET domain protein, putative 0.0036 0.0137 0.1462
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0003 0.0006
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0028 0.0091 0.0165
Schistosoma mansoni carbon catabolite repressor protein 0.0016 0.0026 0.0035
Brugia malayi beta-lactamase family protein 0.0153 0.0783 0.1548
Mycobacterium leprae Probable polyketide synthase Pks1 0.0029 0.01 0.1253
Trypanosoma brucei ISWI complex protein 0.0018 0.0036 0.0432
Onchocerca volvulus 0.0017 0.0031 0.0202
Echinococcus multilocularis traf and tnf receptor associated protein 0.0016 0.0026 0.0024
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0169 0.0166
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0003 0.0004
Brugia malayi RNA, U transporter 1 0.0081 0.0384 0.076
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1518 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.0555 0.7076
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0045 0.0543
Loa Loa (eye worm) hypothetical protein 0.0048 0.0205 0.0406
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0482 0.0641
Entamoeba histolytica calpain large subunit domain III containing protein 0.0019 0.0045 0.0809
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0137 0.0182
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0026 0.0307
Mycobacterium tuberculosis Probable exported protein 0.0016 0.0026 0.0045
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0199 0.0393
Trichomonas vaginalis esterase, putative 0.0153 0.0783 0.5155
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0026 0.0052
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0061 0.0081
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0003 0.0019
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.025 0.0332
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0115 0.0573 0.1134
Echinococcus granulosus importin subunit beta 1 0.0028 0.0095 0.0126
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0003
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0047 0.0063
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0026 0.0307
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0543
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.009 0.0593
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0212 0.1395
Echinococcus multilocularis hypothetical protein 0.0019 0.0045 0.0042
Schistosoma mansoni ap endonuclease 0.0079 0.0377 0.0501
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.01 0.049 0.6247
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0053 0.0106
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0029 0.01 0.0183
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0003 0.0006
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0027 0.0086 0.0157
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0543
Loa Loa (eye worm) hypothetical protein 0.0028 0.0095 0.0188
Echinococcus multilocularis deoxyribonuclease 1 2 0.0016 0.0026 0.0024
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0029 0.01 0.0183
Mycobacterium leprae Probable lipase LipE 0.0153 0.0783 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0031 0.0061
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0026 0.0175
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0003 0.0006
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0026 0.0307
Schistosoma mansoni hypothetical protein 0.0115 0.0573 0.0762
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.025 0.0332
Echinococcus granulosus lysosomal alpha glucosidase 0.0333 0.1779 0.2366
Trypanosoma brucei RNA editing exonuclease 2 0.0016 0.0026 0.0307
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0281 0.0374
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.009 0.0593
Giardia lamblia Inositol 5-phosphatase 4 0.0016 0.0026 0.0641
Brugia malayi Bromodomain containing protein 0.0045 0.0184 0.0364
Leishmania major importin beta-1 subunit, putative 0.0023 0.0065 0.0803
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0137 0.0182
Mycobacterium ulcerans polyketide synthase Pks13 0.0041 0.0166 0.21
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0048 0.0205 0.135
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0026 0.0307
Onchocerca volvulus 0.0046 0.019 0.1254
Leishmania major hypothetical protein, conserved 0.0153 0.0783 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.0555 0.7076
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0016 0.0026 0.0175
Trichomonas vaginalis hypothetical protein 0.0048 0.0205 0.135
Entamoeba histolytica hypothetical protein 0.0072 0.0333 0.6008
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0048 0.0205 0.0406
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0045 0.006
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0045 0.0543
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0003 0.0019
Trichomonas vaginalis D-aminoacylase, putative 0.0153 0.0783 0.5155
Trichomonas vaginalis ran, putative 0.0021 0.0053 0.0352
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0543
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0003 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0031 0.0202
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0031 0.0202
Echinococcus granulosus GPCR family 2 0.0115 0.0573 0.0762
Loa Loa (eye worm) hypothetical protein 0.0046 0.019 0.0377
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0095 0.1183
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0291 0.3702
Loa Loa (eye worm) hypothetical protein 0.0045 0.0184 0.0365
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.013 0.0173
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0045 0.0543
Brugia malayi Glycosyl hydrolases family 31 protein 0.0074 0.0346 0.0685
Echinococcus multilocularis neuropeptide receptor A26 0.0467 0.2518 0.2516
Echinococcus multilocularis cysteine protease 0.0017 0.0031 0.0028
Echinococcus granulosus cathepsin l1 0.0017 0.0031 0.0041
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0016 0.0026 0.0478
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0031 0.0041
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0006
Mycobacterium tuberculosis Probable esterase LipL 0.0153 0.0783 0.1463
Schistosoma mansoni microtubule-associated protein tau 0.1372 0.752 1
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0045 0.0543
Schistosoma mansoni inositol monophosphatase 0.0112 0.0555 0.0737
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0003 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0031 0.0202
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0048 0.0205 0.2596
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0006
Leishmania major hypothetical protein, conserved 0.0016 0.0026 0.0307
Brugia malayi hypothetical protein 0.0231 0.1216 0.2406
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0031 0.0553
Schistosoma mansoni inositol monophosphatase 0.0112 0.0555 0.0737
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0031 0.0553
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.009 0.0178
Loa Loa (eye worm) hypothetical protein 0.0017 0.0031 0.0061
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0047 0.0063
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0012 0.0003 0.0046
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0028 0.0091 0.0165
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0003 0.0004
Echinococcus granulosus neuropeptide receptor A26 0.0467 0.2518 0.3349
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0003 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0281 0.0374
Brugia malayi Pre-SET motif family protein 0.0251 0.1326 0.2623
Onchocerca volvulus 0.0193 0.1003 0.6603
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0026 0.0024
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0026 0.0052
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0346 0.2281
Trichomonas vaginalis penicillin-binding protein, putative 0.0153 0.0783 0.5155
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0003 0.0004
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0045 0.0543
Loa Loa (eye worm) calpain 5 0.0019 0.0045 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0031 0.0202
Mycobacterium leprae Polyketide synthase Pks13 0.0041 0.0166 0.21
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0112 0.0555 1
Chlamydia trachomatis 3'(2'),5'-bisphosphate nucleotidase CysQ 0.0012 0.0003 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0003 0.0006
Echinococcus multilocularis lysosomal alpha glucosidase 0.0333 0.1779 0.1777
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0031 0.0202
Brugia malayi PHD-finger family protein 0.0029 0.0098 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0003 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0031 0.0202
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0048 0.0205 0.5098
Echinococcus multilocularis inositol monophosphatase 1 0.0112 0.0555 0.0552
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0029 0.01 0.1253
Entamoeba histolytica cysteine protease, putative 0.0017 0.0031 0.0553
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0333 0.0331
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0016 0.0026 0.0307
Schistosoma mansoni hypothetical protein 0.0115 0.0573 0.0762
Loa Loa (eye worm) hypothetical protein 0.0153 0.0783 0.1548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0031 0.0202
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0065 0.0297 0.0395
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0112 0.0555 1
Echinococcus granulosus microtubule associated protein 2 0.1372 0.752 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.025 0.0247
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0053 0.0652
Trichomonas vaginalis inositol monophosphatase, putative 0.0112 0.0555 0.3652
Loa Loa (eye worm) inositol-1 0.0112 0.0555 0.1097
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0003 0.0004
Entamoeba histolytica protein kinase, putative 0.0019 0.0045 0.0809
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0211 0.1106 0.1104
Brugia malayi exodeoxyribonuclease III family protein 0.0079 0.0377 0.0745
Brugia malayi Inositol-1 0.0112 0.0555 0.1097
Echinococcus granulosus sphingomyelin synthase protein 1 0.0048 0.0205 0.0273
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0079 0.0377 0.4632
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0212 0.0282
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0482 0.0641
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.009 0.0593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0031 0.0202
Loa Loa (eye worm) calpain family protein 1 0.0046 0.019 0.0377
Echinococcus multilocularis neuropeptide s receptor 0.0467 0.2518 0.2516
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.1613 0.3191
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0026 0.0307
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.009 0.1122
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0048 0.0205 0.135
Brugia malayi hypothetical protein 0.0072 0.0333 0.0659
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0291 0.3702
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0026 0.0052
Loa Loa (eye worm) hypothetical protein 0.0028 0.009 0.0178
Entamoeba histolytica hypothetical protein 0.0072 0.0333 0.6008
Leishmania major hypothetical protein, conserved 0.0018 0.0036 0.0432
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0026 0.0307
Onchocerca volvulus 0.0012 0.0003 0.0019
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0047 0.0063
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0079 0.0377 0.0501
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0031 0.0061
Onchocerca volvulus 0.0017 0.0031 0.0202
Echinococcus granulosus neuropeptide s receptor 0.0467 0.2518 0.3349
Trichomonas vaginalis ap endonuclease, putative 0.0079 0.0377 0.2481
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0291 0.3702
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0153 0.0783 0.1463
Loa Loa (eye worm) hypothetical protein 0.0153 0.0783 0.1548
Brugia malayi steroid hormone receptor 0.0012 0.0003 0.0006
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0026 0.0307
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0026 0.0307
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0333 0.1779 0.3518
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0363 0.1946 0.3848
Leishmania major cathepsin L-like protease 0.0017 0.0031 0.0361
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0083 0.011
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0074 0.0346 0.6246
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0026 0.0081 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0003 0.0006
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0543
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0026 0.0052
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0012 0.0003 0.0017
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0095 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0346 0.4408
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0003 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0291 0.3702
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0053 0.0071
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0048 0.0205 0.5098
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0333 0.0443
Schistosoma mansoni hypothetical protein 0.0115 0.0573 0.0762
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.009 0.0593
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0051 0.0102
Echinococcus granulosus histone lysine methyltransferase setb 0.0056 0.0247 0.0328
Onchocerca volvulus Putative neutral sphingomyelinase 0.0016 0.0026 0.0175
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0291 0.3702
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.01 0.049 0.0914
Onchocerca volvulus 0.0286 0.1518 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0346 0.2281
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0003 0.0006
Brugia malayi calpain 5 0.0019 0.0045 0.0089
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0291 0.3702
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0003 0.0004
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.1216 0.1618
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.007 0.0139
Trypanosoma brucei glycosyl hydrolase-like protein 0.0028 0.009 0.1122
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0031 0.0202
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.009 0.0593
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0346 0.4408
Loa Loa (eye worm) hypothetical protein 0.005 0.0212 0.0419
Loa Loa (eye worm) MBCTL1 0.0056 0.025 0.0494
Treponema pallidum exodeoxyribonuclease (exoA) 0.0079 0.0377 1
Mycobacterium ulcerans polyketide synthase 0.0028 0.0091 0.1131
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0026 0.0307
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0006
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0112 0.0555 0.7076
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0026 0.0052
Trichomonas vaginalis D-aminoacylase, putative 0.0153 0.0783 0.5155
Plasmodium vivax importin-beta 2, putative 0.0028 0.0095 0.0904
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0003 0.0006
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0012 0.0003 0.0046
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0045 0.006

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 0.8913 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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