Detailed information for compound 1241298

Basic information

Technical information
  • TDR Targets ID: 1241298
  • Name: 1-[(4-bromophenyl)methyl]-4-(2-methoxyphenyl) piperazine; oxalic acid
  • MW: 451.311 | Formula: C20H23BrN2O5
  • H donors: 2 H acceptors: 4 LogP: 1.48 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(=O)O.COc1ccccc1N1CCN(CC1)Cc1ccc(cc1)Br
  • InChi: 1S/C18H21BrN2O.C2H2O4/c1-22-18-5-3-2-4-17(18)21-12-10-20(11-13-21)14-15-6-8-16(19)9-7-15;3-1(4)2(5)6/h2-9H,10-14H2,1H3;(H,3,4)(H,5,6)
  • InChiKey: DPZLWFHPULANMP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4-bromobenzyl)-4-(2-methoxyphenyl)piperazine; oxalic acid
  • 1-[(4-bromophenyl)methyl]-4-(2-methoxyphenyl)piperazine; ethanedioic acid
  • 1-(4-Bromo-benzyl)-4-(2-methoxy-phenyl)-piperazine
  • MLS001205108
  • SMR000516041

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0034 0.0113
Echinococcus granulosus smad 0.0016 0.0034 0.0041
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0407 0.3771
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0666 0.3821
Loa Loa (eye worm) hypothetical protein 0.0186 0.1078 0.3549
Loa Loa (eye worm) hypothetical protein 0.0199 0.1158 0.3815
Brugia malayi calpain 7 0.0019 0.0051 0.0168
Brugia malayi Glycosyl hydrolases family 31 protein 0.0503 0.3036 1
Echinococcus multilocularis calpain 5 0.0019 0.0051 0.0051
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0113 0.1049
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0035 0.0035
Echinococcus granulosus importin subunit beta 1 0.0029 0.0113 0.0135
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0666 0.2193
Echinococcus granulosus neuropeptide s receptor 0.0464 0.2792 0.3319
Echinococcus granulosus dnaJ subfamily B 0.0427 0.2567 0.3052
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0034 0.0041
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0118 0.0387
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0189 0.1086
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0503 0.3036 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0039 0.0046
Echinococcus granulosus tumor protein p63 0.0344 0.2052 0.2439
Echinococcus multilocularis mitogen activated protein kinase 11 0.0126 0.0707 0.0707
Loa Loa (eye worm) hypothetical protein 0.005 0.0243 0.08
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0131 0.075
Entamoeba histolytica hypothetical protein 0.0144 0.0818 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0329 0.1085
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.1376 0.1376
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0056 0.0185
Brugia malayi phosphofructokinase 0.0119 0.0666 0.2193
Mycobacterium ulcerans hypothetical protein 0.0186 0.1078 0.6185
Plasmodium vivax sphingomyelin synthase 2, putative 0.0025 0.0085 0.0496
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0126 0.0707 0.6563
Loa Loa (eye worm) calpain 5 0.0019 0.0051 0.0168
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0131 0.075
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0034 0.0113
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0407 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0112 0.0621 0.2046
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0621 0.5764
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0042 0.0189 0.1752
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0033 0.011
Schistosoma mansoni hypothetical protein 0.0034 0.0145 0.0173
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0666 0.6176
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0329 0.0329
Schistosoma mansoni hypothetical protein 0.0064 0.0329 0.0391
Plasmodium vivax importin-beta 2, putative 0.0029 0.0113 0.0767
Echinococcus multilocularis mitogen activated protein kinase 14 0.0126 0.0707 0.0707
Schistosoma mansoni cpg binding protein 0.0034 0.014 0.0166
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0033 0.0193
Brugia malayi hypothetical protein 0.0234 0.1376 0.4533
Schistosoma mansoni lamin 0.0027 0.0097 0.0116
Brugia malayi Cytochrome P450 family protein 0.002 0.0056 0.0185
Schistosoma mansoni cpg binding protein 0.003 0.0118 0.014
Mycobacterium tuberculosis Probable lipase LipD 0.0186 0.1078 0.1486
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0034 0.0034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.1115 0.1325
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.028
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0219 0.1256
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0407 0.3771
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0034 0.0041
Brugia malayi CXXC zinc finger family protein 0.003 0.0118 0.0387
Trichomonas vaginalis alpha-glucosidase, putative 0.0112 0.0621 0.3566
Echinococcus multilocularis hypothetical protein 0.0019 0.0051 0.0051
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0078 0.0078
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0078 0.0413 0.3745
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.0872 0.0872
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0666 0.3821
Brugia malayi glutaminase DH11.1 0.0293 0.1742 0.5738
Echinococcus multilocularis GPCR, family 2 0.0064 0.0329 0.0329
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0033 0.004
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0078 0.0413 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0112 0.0621 0.7594
Mycobacterium tuberculosis Conserved protein 0.0186 0.1078 0.1486
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0145 0.0145
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0025 0.0085 0.0786
Schistosoma mansoni ferritin 0.0017 0.0036 0.0042
Loa Loa (eye worm) cytochrome P450 0.0011 0 0.0001
Schistosoma mansoni ferritin 0.0017 0.0036 0.0042
Echinococcus granulosus calpain 5 0.0019 0.0051 0.0061
Echinococcus multilocularis lysosomal alpha glucosidase 0.0503 0.3036 0.3036
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0112 0.0621 0.7594
Loa Loa (eye worm) calpain 0.0019 0.0051 0.0168
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0407 0.3771
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0042 0.0189 0.1752
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0163 0.0538
Schistosoma mansoni survival motor neuron protein 0.0048 0.0227 0.027
Schistosoma mansoni zinc finger protein 0.0024 0.0083 0.0099
Mycobacterium ulcerans beta-lactamase 0.0186 0.1078 0.6185
Onchocerca volvulus 0.0016 0.0033 0.0193
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.1115 0.1325
Schistosoma mansoni microtubule-associated protein tau 0.1375 0.8412 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0283 0.2622
Entamoeba histolytica hypothetical protein 0.0025 0.0085 0.104
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0079 0.0455
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0219 0.1256
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0112 0.0621 0.5631
Trypanosoma brucei glycosyl hydrolase-like protein 0.0042 0.0189 0.1752
Brugia malayi Stress-activated protein kinase jnk-1 0.023 0.1348 0.4441
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.0029
Onchocerca volvulus 0.0186 0.1078 0.6238
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0051 0.0471
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0189 0.1086
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0186 0.1078 0.1486
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0113 0.1025
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0051 0.0471
Toxoplasma gondii aldehyde dehydrogenase 0.019 0.1103 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.028
Loa Loa (eye worm) CYP4Cod1 0.002 0.0056 0.0185
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0163 0.1246
Onchocerca volvulus 0.0016 0.0033 0.0193
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0182 0.2225
Loa Loa (eye worm) acetyltransferase 0.0152 0.0872 0.2872
Schistosoma mansoni alpha-glucosidase 0.0433 0.2604 0.3096
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0186 0.1078 0.1486
Entamoeba histolytica hypothetical protein 0.0025 0.0085 0.104
Mycobacterium tuberculosis Probable esterase LipL 0.0186 0.1078 0.1486
Trypanosoma brucei hypothetical protein, conserved 0.0186 0.1078 1
Echinococcus multilocularis ferritin 0.0017 0.0036 0.0035
Trichomonas vaginalis esterase, putative 0.0186 0.1078 0.6186
Echinococcus granulosus microtubule associated protein 2 0.1375 0.8412 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0078 0.0413 0.5052
Onchocerca volvulus 0.0186 0.1078 0.6238
Echinococcus granulosus GPCR family 2 0.0064 0.0329 0.0391
Schistosoma mansoni apoferritin-2 0.0017 0.0036 0.0042
Brugia malayi Glycosyl hydrolases family 31 protein 0.0112 0.0621 0.2046
Loa Loa (eye worm) Smad1 0.0016 0.0034 0.0113
Leishmania major cathepsin L-like protease 0.0016 0.0033 0.0298
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0227 0.0748
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0186 0.1078 0.1281
Schistosoma mansoni ap endonuclease 0.0037 0.0163 0.0194
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0113 0.1049
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0051 0.046
Echinococcus granulosus sphingomyelin synthase protein 1 0.0025 0.0085 0.0101
Leishmania major cathepsin L-like protease 0.0016 0.0033 0.0298
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.1423 0.4688
Leishmania major hypothetical protein, conserved 0.0186 0.1078 0.977
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0036 0.0202
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0033 0.0407
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0078 0.0093
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0056 0.0519
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0033 0.0033
Schistosoma mansoni glutaminase 0.0293 0.1742 0.2071
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.1376 0.1636
Toxoplasma gondii cathepsin CPL 0.0016 0.0033 0.0298
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0033 0.0191
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0666 0.0791
Mycobacterium ulcerans aldehyde dehydrogenase 0.019 0.1103 0.6331
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0068 0.0351 0.0418
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0131 0.1182
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0474 0.2854 0.94
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0186 0.1078 0.6185
Trichomonas vaginalis penicillin-binding protein, putative 0.0186 0.1078 0.6186
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0163 0.3385
Mycobacterium ulcerans aldehyde dehydrogenase 0.019 0.1103 0.6331
Loa Loa (eye worm) inositol-1 0.0078 0.0413 0.1361
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0112 0.0621 0.3566
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0163 0.0194
Entamoeba histolytica calpain large subunit domain III containing protein 0.0019 0.0051 0.0625
Schistosoma mansoni ferritin 0.0017 0.0036 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0033 0.0191
Echinococcus granulosus snurportin 1 0.0313 0.1863 0.2215
Echinococcus granulosus beta LACTamase domain containing family member 0.0186 0.1078 0.1281
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0192 0.1115 0.3671
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0112 0.0621 0.3566
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0051 0.0471
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0051 0.0471
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0163 0.0936
Loa Loa (eye worm) hypothetical protein 0.0186 0.1078 0.3549
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0131 0.1182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0033 0.0191
Brugia malayi calpain family protein 1 0.0065 0.0331 0.109
Loa Loa (eye worm) beta-lactamase 0.0186 0.1078 0.3549
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0051 0.0471
Entamoeba histolytica hypothetical protein 0.0024 0.0079 0.0968
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0025 0.0085 0.0786
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0316 0.2931
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0145 0.0173
Entamoeba histolytica hypothetical protein 0.0144 0.0818 1
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0163 0.0538
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.1115 0.1114
Trichomonas vaginalis hypothetical protein 0.0025 0.0085 0.0488
Brugia malayi Cathepsin L-like precursor 0.0016 0.0033 0.011
Brugia malayi MH2 domain containing protein 0.0016 0.0034 0.0113
Brugia malayi hypothetical protein 0.005 0.0239 0.0786
Onchocerca volvulus 0.005 0.0243 0.1405
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0034 0.0034
Schistosoma mansoni inositol monophosphatase 0.0078 0.0413 0.0491
Schistosoma mansoni calpain (C02 family) 0.0019 0.0051 0.0061
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0219 0.026
Schistosoma mansoni hypothetical protein 0.0048 0.0227 0.027
Loa Loa (eye worm) hypothetical protein 0.0065 0.0331 0.109
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0097 0.0321
Schistosoma mansoni smad 0.0016 0.0034 0.0041
Mycobacterium tuberculosis Probable lipase LipE 0.0186 0.1078 0.1486
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0131 0.1182
Brugia malayi Cathepsin L-like precursor 0.0016 0.0033 0.011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0163 0.1513
Schistosoma mansoni aldehyde dehydrogenase 0.019 0.1103 0.1311
Schistosoma mansoni apoferritin-2 0.0017 0.0036 0.0042
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0163 0.0938
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0061 0.0202
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0113 0.0113
Leishmania major importin beta-1 subunit, putative 0.0024 0.0079 0.0715
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.0832 0.0989
Brugia malayi 6-phosphofructokinase 0.0119 0.0666 0.2193
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.028
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0163 0.0938
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0163 0.1513
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0033 0.0191
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0219 0.1777
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0189 0.1086
Schistosoma mansoni lamin 0.0027 0.0097 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0033 0.0191
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0329 0.1085
Schistosoma mansoni alpha-glucosidase 0.0433 0.2604 0.3096
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0407 0.3575
Brugia malayi Cathepsin L-like precursor 0.0016 0.0033 0.011
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0131 0.1597
Loa Loa (eye worm) hypothetical protein 0.0043 0.02 0.0657
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0144 0.0818 0.0818
Schistosoma mansoni hypothetical protein 0.002 0.0056 0.0067
Brugia malayi Bromodomain containing protein 0.0041 0.0185 0.0609
Loa Loa (eye worm) glutaminase 0.0293 0.1742 0.5738
Schistosoma mansoni hypothetical protein 0.0139 0.079 0.0939
Trypanosoma cruzi hypothetical protein, conserved 0.0186 0.1078 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0033 0.0191
Echinococcus multilocularis cpg binding protein 0.0034 0.014 0.0139
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0025 0.0085 0.0786
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0316 0.2931
Entamoeba histolytica hypothetical protein 0.0025 0.0085 0.104
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0033 0.0305
Trypanosoma cruzi hypothetical protein, conserved 0.0186 0.1078 1
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0025 0.0085 0.028
Loa Loa (eye worm) hypothetical protein 0.0065 0.0331 0.109
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0148 0.0148
Brugia malayi calpain 5 0.0019 0.0051 0.0168
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0163 0.1478
Brugia malayi Cathepsin L-like precursor 0.0016 0.0033 0.011
Brugia malayi beta-lactamase family protein 0.0186 0.1078 0.3549
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0189 0.2311
Loa Loa (eye worm) hypothetical protein 0.0016 0.0033 0.011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0033 0.0191
Schistosoma mansoni calpain-7 (C02 family) 0.0029 0.0109 0.013
Brugia malayi MH1 domain containing protein 0.0016 0.0034 0.0113
Loa Loa (eye worm) hypothetical protein 0.0077 0.0407 0.1339
Trypanosoma brucei kinesin, putative 0.0019 0.0051 0.0471
Brugia malayi MH1 domain containing protein 0.0016 0.0034 0.0113
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0097 0.0321
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.1115 0.1325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0033 0.0191
Leishmania major hypothetical protein, conserved 0.0015 0.0024 0.0217
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0163 0.1997
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.1115 0.1325
Schistosoma mansoni hypothetical protein 0.0064 0.0329 0.0391
Echinococcus multilocularis tumor protein p63 0.0344 0.2052 0.2051
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0131 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0033 0.0191
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0025 0.0085 0.028
Echinococcus multilocularis neuropeptide s receptor 0.0464 0.2792 0.2791
Schistosoma mansoni ferritin 0.0017 0.0036 0.0042
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.028
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0051 0.046
Schistosoma mansoni smad1 5 8 and 0.0016 0.0034 0.0041
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0189 0.0623
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0316 0.2931
Loa Loa (eye worm) ctsf protein 0.0016 0.0033 0.011
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0033 0.0033
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0025 0.0085 0.0786
Leishmania major kinesin, putative 0.0019 0.0051 0.046
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.032 0.2898
Schistosoma mansoni hypothetical protein 0.0064 0.0329 0.0391
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0182 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0189 0.1086
Loa Loa (eye worm) calpain family protein 1 0.0065 0.0331 0.109
Leishmania major cytochrome p450-like protein 0.002 0.0056 0.0507
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0033 0.0407
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0068 0.0351 0.0418
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.003
Echinococcus granulosus c-Jun N-terminal kinases 0.023 0.1348 0.1603
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.019 0.1103 0.1521
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0051 0.0471
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0056 0.0185
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.0413 0.2372
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0021 0.0069
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0051 0.0471
Schistosoma mansoni cpg binding protein 0.0034 0.014 0.0166
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0025 0.0085 0.0085
Onchocerca volvulus 0.0027 0.0097 0.0564
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0025 0.0085 0.1388
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0033 0.0191
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0413 0.3833
Echinococcus multilocularis calpain 0.0019 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0033 0.0191
Trypanosoma brucei antigen, putative 0.0019 0.0051 0.0471
Loa Loa (eye worm) calpain family protein 1 0.0045 0.0212 0.0699
Schistosoma mansoni Smad4 0.0016 0.0034 0.0041
Mycobacterium leprae Probable lipase LipE 0.0186 0.1078 1
Plasmodium vivax hypothetical protein, conserved 0.0186 0.1078 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0035 0.0041
Echinococcus multilocularis neuropeptide receptor A26 0.0464 0.2792 0.2791
Echinococcus granulosus mitogen activated protein kinase 11 0.0126 0.0707 0.0841
Echinococcus multilocularis calpain family protein 1, d 0.0045 0.0212 0.0212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0316 0.2931
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0316 0.2931
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0316 0.2931
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0033 0.0191
Echinococcus multilocularis neutral alpha glucosidase AB 0.0112 0.0621 0.0621
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0126 0.0707 0.6412
Onchocerca volvulus 0.0186 0.1078 0.6238
Leishmania major ATP-dependent phosphofructokinase 0.0119 0.0666 0.6034
Onchocerca volvulus 0.0016 0.0033 0.0193
Entamoeba histolytica hypothetical protein 0.0144 0.0818 1
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0126 0.0707 0.6563
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0666 0.3821
Brugia malayi Sphingomyelin synthase-related 1 0.0025 0.0085 0.028
Schistosoma mansoni aldehyde dehydrogenase 0.019 0.1103 0.1311
Toxoplasma gondii ABC1 family protein 0.0186 0.1078 0.977
Echinococcus granulosus lamin 0.0027 0.0097 0.0116
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0128
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0051 0.0471
Trichomonas vaginalis glutaminase, putative 0.0293 0.1742 1
Echinococcus multilocularis smad 0.0016 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0313 0.1863 0.2215
Echinococcus multilocularis inositol monophosphatase 1 0.0078 0.0413 0.0413
Trichomonas vaginalis D-aminoacylase, putative 0.0186 0.1078 0.6186
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0407 0.3684
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0033 0.0033
Echinococcus multilocularis microtubule associated protein 2 0.1375 0.8412 0.8412
Trichomonas vaginalis maltase-glucoamylase, putative 0.0112 0.0621 0.3566
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0316 0.2931
Trichomonas vaginalis sucrase-isomaltase, putative 0.0112 0.0621 0.3566
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0189 0.1086
Mycobacterium ulcerans esterase/lipase LipP 0.0186 0.1078 0.6185
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0182 0.3983
Brugia malayi RNA, U transporter 1 0.0083 0.0447 0.1472
Trichomonas vaginalis alpha-glucosidase, putative 0.0112 0.0621 0.3566
Echinococcus granulosus intermediate filament protein 0.0027 0.0097 0.0116
Brugia malayi Importin beta-1 subunit 0.0029 0.0113 0.0374
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0033 0.011
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0025 0.0085 0.1388
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0234 0.2169
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0329 0.0391
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0025 0.0085 0.0488
Echinococcus granulosus calpain 0.0019 0.0051 0.0061
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0039 0.0039
Trypanosoma brucei glucosidase, putative 0.0112 0.0621 0.5764
Echinococcus granulosus neutral alpha glucosidase AB 0.0112 0.0621 0.0739
Trichomonas vaginalis D-aminoacylase, putative 0.0186 0.1078 0.6186
Schistosoma mansoni zinc finger protein 0.0015 0.0024 0.0029
Leishmania major cathepsin L-like protease 0.0016 0.0033 0.0298
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0119 0.0666 0.0918
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0033 0.0191
Leishmania major alpha glucosidase II subunit, putative 0.0112 0.0621 0.5631
Entamoeba histolytica hypothetical protein 0.0025 0.0085 0.104
Echinococcus granulosus 6 phosphofructokinase 0.0119 0.0666 0.0791
Brugia malayi beta-lactamase family protein 0.0186 0.1078 0.3549
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0025 0.0085 0.0488
Schistosoma mansoni hypothetical protein 0.069 0.4185 0.4975
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0033 0.0191
Onchocerca volvulus 0.0048 0.0227 0.1314
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0131 0.075
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0666 0.8137
Trypanosoma brucei ISWI complex protein 0.0015 0.0024 0.0223
Echinococcus granulosus cpg binding protein 0.0034 0.014 0.0166
Toxoplasma gondii hypothetical protein 0.0025 0.0085 0.0768
Trypanosoma cruzi kinesin, putative 0.0019 0.0051 0.0471
Loa Loa (eye worm) hypothetical protein 0.0474 0.2854 0.94
Brugia malayi 6-phosphofructokinase 0.0119 0.0666 0.2193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0033 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0193 0.1125 0.6456
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0033 0.0191
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0666 0.8137
Echinococcus granulosus zinc finger protein 0.0024 0.0083 0.0099
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0666 0.6176
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0033 0.0193
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0078 0.0413 0.2371
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0329 0.0329
Trichomonas vaginalis D-aminoacylase, putative 0.0186 0.1078 0.6186
Brugia malayi MH2 domain containing protein 0.0242 0.1423 0.4688
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0051 0.0471
Schistosoma mansoni ferritin light chain 0.0017 0.0036 0.0042
Loa Loa (eye worm) hypothetical protein 0.0186 0.1078 0.3549
Schistosoma mansoni spingomyelin synthetase-related 0.0025 0.0085 0.0101
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0039 0.0046
Brugia malayi intermediate filament protein 0.0027 0.0097 0.0321
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0244 0.0804
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0033 0.0191
Echinococcus multilocularis c Jun NH2 terminal kinase 0.023 0.1348 0.1348
Echinococcus granulosus cathepsin l1 0.0016 0.0033 0.004
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0126 0.0707 0.6563
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0025 0.0085 0.028
Loa Loa (eye worm) glutaminase 2 0.0293 0.1742 0.5738
Trichomonas vaginalis alpha-glucosidase, putative 0.0112 0.0621 0.3566
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0219 0.1981
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0163 0.2029
Echinococcus multilocularis zinc finger protein 0.0024 0.0083 0.0083
Onchocerca volvulus 0.0016 0.0033 0.0193
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0036 0.0049
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0186 0.1078 0.1281
Onchocerca volvulus 0.0016 0.0033 0.0193
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0329 0.0391
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0025 0.0085 0.028
Loa Loa (eye worm) hypothetical protein 0.0069 0.0357 0.1175
Brugia malayi Smad1 0.0016 0.0034 0.0113
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0035 0.0041
Trichomonas vaginalis ferritin, putative 0.0017 0.0036 0.0204
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0413 0.3833
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0666 0.0791
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0203 0.1186 0.3908
Entamoeba histolytica hypothetical protein 0.0025 0.0085 0.104
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.028
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.1423 0.4688
Echinococcus multilocularis 6 phosphofructokinase 0.0119 0.0666 0.0665
Loa Loa (eye worm) phosphofructokinase 0.0119 0.0666 0.2193
Trichomonas vaginalis penicillin-binding protein, putative 0.0186 0.1078 0.6186
Onchocerca volvulus 0.0291 0.1728 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0051 0.046
Trypanosoma brucei cytochrome P450, putative 0.002 0.0056 0.0519
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0097 0.0321
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0065 0.0331 0.0393
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0039 0.0046
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0192 0.1115 0.3671
Echinococcus granulosus expressed protein 0.0017 0.0036 0.0042
Schistosoma mansoni transcription factor LCR-F1 0.0144 0.0818 0.0973
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.004
Brugia malayi Cathepsin L-like precursor 0.0016 0.0033 0.011
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0045 0.0212 0.0699
Echinococcus granulosus inositol monophosphatase 1 0.0078 0.0413 0.0491
Echinococcus granulosus lysosomal alpha glucosidase 0.0503 0.3036 0.3609
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0051 0.0471
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0189 0.1086
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0033 0.004
Brugia malayi Inositol-1 0.0078 0.0413 0.1361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0316 0.2931
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.1863 0.6136
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0079 0.0455
Brugia malayi Cytochrome P450 family protein 0.0011 0 0.0001
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0163 0.6376
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0051 0.0061
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0163 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0033 0.0191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0316 0.2931
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0666 0.8137
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0324 0.0385
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0025 0.0085 0.0488
Brugia malayi PHD-finger family protein 0.003 0.0115 0.0379
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0243 0.0289
Loa Loa (eye worm) hypothetical protein 0.0045 0.0212 0.0699
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.023 0.1348 0.4441
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0163 0.0163
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0666 0.2193
Mycobacterium ulcerans lipase LipD 0.0186 0.1078 0.6185
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0051 0.0061
Leishmania major cathepsin L-like protease 0.0016 0.0033 0.0298
Leishmania major cathepsin L-like protease 0.0062 0.0316 0.2864
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0068 0.0351 0.0418
Brugia malayi P38 map kinase family protein 2 0.0126 0.0707 0.233
Echinococcus granulosus mitogen activated protein kinase 14 0.0126 0.0707 0.0841
Loa Loa (eye worm) hypothetical protein 0.0186 0.1078 0.3549
Leishmania major cathepsin L-like protease 0.0062 0.0316 0.2864
Schistosoma mansoni smad1 5 8 and 0.0016 0.0034 0.0041
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0036 0.0049
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.019 0.1103 0.1103
Echinococcus multilocularis lamin dm0 0.0027 0.0097 0.0097
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0325 0.0386
Plasmodium falciparum importin beta, putative 0.0029 0.0113 0.2147
Echinococcus multilocularis mitogen activated protein kinase 11 0.0126 0.0707 0.0707
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0131 0.2608
Echinococcus granulosus ferritin 0.0017 0.0036 0.0042
Echinococcus granulosus calpain A 0.0068 0.0351 0.0418
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0119 0.0666 0.6176
Toxoplasma gondii exonuclease III APE 0.0037 0.0163 0.1478
Schistosoma mansoni calpain-7 (C02 family) 0.0029 0.0109 0.013
Echinococcus granulosus lamin dm0 0.0027 0.0097 0.0116
Loa Loa (eye worm) hypothetical protein 0.0042 0.0189 0.0623
Entamoeba histolytica protein kinase, putative 0.002 0.0057 0.0694
Echinococcus multilocularis cysteine protease 0.0016 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0033 0.0191
Plasmodium vivax sphingomyelin synthase 1, putative 0.0025 0.0085 0.0496
Leishmania major hypothetical protein, conserved 0.0077 0.0407 0.3684
Echinococcus multilocularis cysteine protease 0.0016 0.0033 0.0033
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0051 0.0471
Loa Loa (eye worm) hypothetical protein 0.0234 0.1376 0.4533
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0033 0.0191
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0025 0.0085 0.0768
Mycobacterium tuberculosis Conserved protein 0.0186 0.1078 0.1486
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.0413 0.2372
Loa Loa (eye worm) hypothetical protein 0.0139 0.079 0.2601
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0316 0.2931
Mycobacterium tuberculosis Probable hydrolase 0.0186 0.1078 0.1486
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0131 0.2608
Mycobacterium tuberculosis Conserved protein 0.0186 0.1078 0.1486
Entamoeba histolytica hypothetical membrane-spanning protein 0.0025 0.0085 0.104
Brugia malayi Cathepsin L-like precursor 0.0016 0.0033 0.011
Echinococcus multilocularis Smad4 0.0016 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0374
Loa Loa (eye worm) hypothetical protein 0.0186 0.1078 0.3549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0316 0.2931
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0316 0.2931
Onchocerca volvulus 0.0016 0.0033 0.0193
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0034 0.0041
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0189 0.1086
Echinococcus multilocularis mitogen activated protein kinase 14 0.0126 0.0707 0.0707
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0329 0.1085
Loa Loa (eye worm) cysteine protease 0.0016 0.0033 0.011
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.079 0.2601
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0033 0.0298
Schistosoma mansoni hypothetical protein 0.069 0.4185 0.4975
Schistosoma mansoni ferritin light chain 0.0017 0.0036 0.0042
Mycobacterium ulcerans 6-phosphofructokinase 0.0119 0.0666 0.382
Echinococcus multilocularis lysosomal alpha glucosidase 0.0503 0.3036 0.3036
Onchocerca volvulus 0.0027 0.0097 0.0564
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.019 0.1103 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0324 0.0323
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0144 0.0818 0.0973
Schistosoma mansoni bromodomain containing protein 0.0067 0.0345 0.0411
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0119 0.0666 1
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0131 0.075
Onchocerca volvulus 0.0045 0.0212 0.1229
Loa Loa (eye worm) hypothetical protein 0.0037 0.0163 0.0536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0033 0.0191
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0001 0.0002
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0036 0.0326
Plasmodium vivax calpain, putative 0.0019 0.0051 0.0171
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0051 0.0471
Schistosoma mansoni hypothetical protein 0.0064 0.0329 0.0391
Echinococcus multilocularis dnaJ subfamily B 0.0427 0.2567 0.2567
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0316 0.2931
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.003
Brugia malayi MH2 domain containing protein 0.0016 0.0034 0.0113
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0131 0.075
Schistosoma mansoni intermediate filament proteins 0.0027 0.0097 0.0116
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0021 0.0069
Schistosoma mansoni ap endonuclease 0.0037 0.0163 0.0194
Schistosoma mansoni hypothetical protein 0.0427 0.2567 0.3052
Schistosoma mansoni hypothetical protein 0.0144 0.0818 0.0973
Loa Loa (eye worm) fibroinase 0.0016 0.0033 0.011
Leishmania major cathepsin L-like protease 0.0016 0.0033 0.0298
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0051 0.0471
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.0872 0.1037
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0051 0.0471
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0186 0.1078 0.3549
Brugia malayi Calcitonin receptor-like protein seb-1 0.0203 0.1186 0.3908
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0025 0.0085 0.0488
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.019 0.1103 0.1311
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0316 0.2931
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0079 0.0455
Schistosoma mansoni inositol monophosphatase 0.0078 0.0413 0.0491
Entamoeba histolytica cysteine protease, putative 0.0016 0.0033 0.0407
Schistosoma mansoni serine/threonine protein kinase 0.023 0.1348 0.1603
Leishmania major glycosyl hydrolase-like protein 0.0042 0.0189 0.1712
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0033 0.0191
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0163 0.1513
Mycobacterium ulcerans aldehyde dehydrogenase 0.019 0.1103 0.6331
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0203 0.1186 0.3908
Brugia malayi beta-lactamase 0.0186 0.1078 0.3549
Brugia malayi Cytochrome P450 family protein 0.005 0.0244 0.0804
Echinococcus granulosus Smad4 0.0016 0.0034 0.0041
Trypanosoma cruzi kinesin, putative 0.0019 0.0051 0.0471
Entamoeba histolytica hypothetical protein 0.0144 0.0818 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0033 0.0191
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0033 0.0191
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0621 0.5764
Loa Loa (eye worm) hypothetical protein 0.0203 0.1186 0.3908
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0051 0.0061
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0033 0.0193
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0131 0.075
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0042 0.0189 0.1095
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0051 0.0471
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0148 0.0176
Echinococcus multilocularis calpain A 0.0068 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.0186 0.1078 0.3549
Echinococcus multilocularis musashi 0.0027 0.0097 0.0097
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0666 0.3821
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.007 0.0363 0.3365
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0051 0.0051
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0131 0.151
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0012 0.0014
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0033 0.004
Echinococcus multilocularis geminin 0.069 0.4185 0.4185
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0033 0.011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0321
Schistosoma mansoni smad1 5 8 and 0.0016 0.0034 0.0041
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0025 0.0085 0.1388
Echinococcus multilocularis lamin 0.0027 0.0097 0.0097
Echinococcus multilocularis beta LACTamase domain containing family member 0.0186 0.1078 0.1077
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0036 0.0202
Echinococcus multilocularis snurportin 1 0.0313 0.1863 0.1863
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0056 0.0519
Onchocerca volvulus 0.0016 0.0033 0.0193
Trichomonas vaginalis alpha-glucosidase, putative 0.0112 0.0621 0.3566
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.1115 0.1114
Schistosoma mansoni importin beta-1 0.0029 0.0113 0.0135
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0316 0.2931
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.0872 0.2872
Loa Loa (eye worm) hypothetical protein 0.0047 0.0222 0.073
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0079 0.0732
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.1115 0.1325
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0131 0.075
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0068 0.0351 0.0351
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0126 0.0707 0.233
Trypanosoma cruzi ISWI complex protein 0.0015 0.0024 0.0223
Trichomonas vaginalis inositol monophosphatase, putative 0.0078 0.0413 0.2372
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.007 0.0363 0.05
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0311
Brugia malayi Cytochrome P450 family protein 0.002 0.0056 0.0185
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0199 0.1158 0.3815
Echinococcus granulosus neuropeptide receptor A26 0.0464 0.2792 0.3319
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1186 0.7249 1
Echinococcus granulosus geminin 0.069 0.4185 0.4975
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0033 0.004
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0163 0.3485
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0056 0.0321
Schistosoma mansoni alpha glucosidase 0.0112 0.0621 0.0739
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0186 0.1078 0.1486
Mycobacterium leprae conserved hypothetical protein 0.0186 0.1078 1
Brugia malayi Bromodomain containing protein 0.0078 0.0416 0.1369
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0131 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.0329 0.1085
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0035 0.0041
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0131 0.0932
Brugia malayi hypothetical protein 0.0144 0.0818 0.2695
Echinococcus multilocularis expressed protein 0.0017 0.0036 0.0035
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0413 0.3833
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0189 0.1086
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0407 1
Leishmania major cathepsin L-like protease 0.0062 0.0316 0.2864
Mycobacterium ulcerans glutaminase 0.0293 0.1742 1
Brugia malayi hypothetical protein 0.0077 0.0407 0.1339
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0025 0.0085 0.0786
Trypanosoma cruzi ISWI complex protein 0.0015 0.0024 0.0223
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0085 0.0488
Trichomonas vaginalis alpha-glucosidase, putative 0.0112 0.0621 0.3566
Echinococcus granulosus calpain A 0.0019 0.0051 0.0061
Brugia malayi calpain family protein 1 0.0065 0.0331 0.109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0033 0.0191
Brugia malayi cytochrome P450 0.0011 0 0.0001
Onchocerca volvulus 0.003 0.0118 0.0681
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0413 0.3745
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0051 0.0471
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0078 0.0093
Trypanosoma brucei inositol phosphorylceramide synthase 0.0025 0.0085 0.0786
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0219 0.1981
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0056 0.0186
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0186 0.1078 0.3549
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0131 0.0932

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.4716 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.