Detailed information for compound 1087911

Basic information

Technical information
  • TDR Targets ID: 1087911
  • Name: N-phenylphenothiazine-10-carboxamide
  • MW: 318.392 | Formula: C19H14N2OS
  • H donors: 1 H acceptors: 1 LogP: 4.37 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1c2ccccc2Sc2c1cccc2)Nc1ccccc1
  • InChi: 1S/C19H14N2OS/c22-19(20-14-8-2-1-3-9-14)21-15-10-4-6-12-17(15)23-18-13-7-5-11-16(18)21/h1-13H,(H,20,22)
  • InChiKey: YNMBQQBSDFDHFH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-phenyl-10-phenothiazinecarboxamide
  • Oprea1_595012
  • STK067361
  • Oprea1_517446
  • ZINC00267871
  • BAS 01095156
  • Phenothiazine-10-carboxylic acid phenylamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens butyrylcholinesterase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Carboxylesterase family protein butyrylcholinesterase 602 aa 546 aa 30.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0049 0.087
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0074 0.0615
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0014 0.002 0.0023
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0318 0.3527 0.6672
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0001 0.0002
Entamoeba histolytica calpain large subunit domain III containing protein 0.0019 0.0074 0.1082
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0025 0.0144 0.1204
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0001 0.0002
Echinococcus multilocularis zinc finger protein 0.0028 0.0178 0.0178
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0281 0.4157
Schistosoma mansoni neutral sphingomyelinase 0.0012 0.0001 0.0001
Mycobacterium ulcerans thioesterase TesA 0.0022 0.012 0.0854
Loa Loa (eye worm) hypothetical protein 0.0115 0.1186 0.2244
Brugia malayi Cathepsin L-like precursor 0.0016 0.0049 0.0094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0432 0.0435
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0001 0.0002
Trypanosoma brucei inositol phosphorylceramide synthase 0.0025 0.0144 0.1204
Schistosoma mansoni alpha-glucosidase 0.0274 0.3017 0.3038
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.0364 0.0364
Brugia malayi hypothetical protein 0.0014 0.002 0.0038
Trypanosoma brucei glycosyl hydrolase-like protein 0.0026 0.0164 0.1372
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.1186 0.4689
Leishmania major cathepsin L-like protease 0.0016 0.0049 0.0407
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0408 0.0411
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0001 0.0002
Mycobacterium ulcerans Type I modular polyketide synthase 0.0027 0.0171 0.1298
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0049 0.0094
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0408 0.0411
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0151 0.1595 0.3017
Loa Loa (eye worm) beta-lactamase 0.0115 0.1186 0.2244
Schistosoma mansoni BC026374 protein (S09 family) 0.0014 0.002 0.002
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0171 0.0171
Mycobacterium ulcerans polyketide synthase Pks13 0.004 0.0325 0.2616
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.0386 0.5715
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0049 0.087
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0074 0.0615
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0281 0.1107
Leishmania major hypothetical protein, conserved 0.0115 0.1186 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0049 0.0191
Mycobacterium tuberculosis Probable lipase LipE 0.0115 0.1186 0.1423
Mycobacterium ulcerans polyketide synthase 0.0029 0.0191 0.1464
Echinococcus multilocularis lysosomal alpha glucosidase 0.0318 0.3527 0.3527
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0674 0.2663
Schistosoma mansoni cript-related 0.0012 0.0001 0.0001
Loa Loa (eye worm) cysteine protease 0.0016 0.0049 0.0094
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0029 0.0191 0.0228
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0556 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0071 0.0674 0.2663
Loa Loa (eye worm) hypothetical protein 0.0085 0.0835 0.158
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0281 0.2361
Schistosoma mansoni inositol monophosphatase 0.0036 0.0281 0.0283
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0096 0.0096
Leishmania major cathepsin L-like protease 0.0016 0.0049 0.0407
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0025 0.0144 0.2571
Trypanosoma cruzi kinesin, putative 0.0019 0.0074 0.0615
Toxoplasma gondii cathepsin CPL 0.0016 0.0049 0.0407
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0484 0.0487
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0556 0.2196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0191
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0082 0.0681
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Onchocerca volvulus 0.0184 0.1981 0.7835
Loa Loa (eye worm) hypothetical protein 0.0016 0.0049 0.0094
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0049 0.0195
Mycobacterium tuberculosis Probable thioesterase TesA 0.0022 0.012 0.0142
Onchocerca volvulus 0.0014 0.002 0.0079
Mycobacterium tuberculosis Probable hydrolase 0.0115 0.1186 0.1423
Brugia malayi Bromodomain containing protein 0.005 0.0436 0.0825
Loa Loa (eye worm) hypothetical protein 0.0055 0.0496 0.0939
Onchocerca volvulus 0.0232 0.2529 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0038
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0071 0.0674 0.1276
Loa Loa (eye worm) hypothetical protein 0.0062 0.0577 0.1092
Trichomonas vaginalis maltase-glucoamylase, putative 0.0071 0.0674 0.2663
Onchocerca volvulus 0.0014 0.002 0.0079
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0731 0.0736
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0115 0.1186 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.1186 0.2244
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0074 0.0615
Brugia malayi Glycosyl hydrolases family 31 protein 0.0026 0.0164 0.031
Onchocerca volvulus 0.0016 0.0049 0.0195
Onchocerca volvulus 0.0016 0.0049 0.0195
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0025 0.0144 0.0565
Echinococcus granulosus BC026374 protein S09 family 0.0014 0.002 0.002
Onchocerca volvulus 0.0115 0.1186 0.4691
Treponema pallidum exodeoxyribonuclease (exoA) 0.006 0.0556 1
Brugia malayi beta-lactamase family protein 0.0115 0.1186 0.2244
Onchocerca volvulus 0.0115 0.1186 0.4691
Schistosoma mansoni hypothetical protein 0.0096 0.0964 0.0971
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0164 0.0643
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.058 0.4881
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0115 0.1186 0.2244
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0082 0.0803 0.0809
Loa Loa (eye worm) hypothetical protein 0.0207 0.2244 0.4244
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0026 0.0164 0.1372
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.0556 0.4684
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0049 0.005
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0001 0.0002
Brugia malayi Cathepsin L-like precursor 0.0016 0.0049 0.0094
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0049 0.0049
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.006 0.0556 0.0667
Schistosoma mansoni gliotactin 0.0014 0.002 0.002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0261 0.0261
Brugia malayi hypothetical protein 0.0035 0.0261 0.0494
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0096 0.0096
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0408 0.1613
Toxoplasma gondii type I fatty acid synthase, putative 0.0029 0.0191 0.16
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0237 0.0283
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0074 0.0615
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0281 0.1107
Loa Loa (eye worm) bromodomain containing protein 0.0025 0.0152 0.0287
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0049 0.0191
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0018 0.0066 0.0396
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0408 0.0772
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.1186 0.4689
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0074 0.0615
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.1186 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0164 0.031
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0071 0.0674 0.2663
Echinococcus multilocularis calpain 0.0019 0.0074 0.0074
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0027 0.0171 0.094
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0029 0.0191 0.1112
Onchocerca volvulus Putative neutral sphingomyelinase 0.0012 0.0001 0.0005
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.0164 0.0643
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0171 0.0173
Loa Loa (eye worm) hypothetical protein 0.0303 0.3347 0.6331
Echinococcus multilocularis neutral sphingomyelinase 0.0012 0.0001 0.0001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0432 0.0432
Schistosoma mansoni hypothetical protein 0.0025 0.0145 0.0146
Brugia malayi mbt repeat family protein 0.0048 0.0408 0.0772
Trichomonas vaginalis maltase-glucoamylase, putative 0.0026 0.0164 0.0643
Loa Loa (eye worm) hypothetical protein 0.0115 0.1186 0.2244
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0049 0.0191
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0012 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0272
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0001 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.1186 0.1195
Trypanosoma brucei glucosidase, putative 0.0071 0.0674 0.568
Loa Loa (eye worm) carboxylesterase 0.0082 0.0803 0.152
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0074 0.0615
Trypanosoma cruzi ISWI complex protein 0.0018 0.0072 0.0594
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0049 0.0191
Echinococcus granulosus sphingomyelin synthase protein 1 0.0025 0.0144 0.0145
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0164 0.0643
Echinococcus granulosus calpain A 0.0019 0.0074 0.0075
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0074 0.0075
Onchocerca volvulus 0.0025 0.0151 0.0597
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0281 0.2361
Echinococcus granulosus traf and tnf receptor associated protein 0.0012 0.0001 0.0001
Schistosoma mansoni zinc finger protein 0.0028 0.0178 0.0179
Echinococcus multilocularis beta LACTamase domain containing family member 0.0115 0.1186 0.1186
Echinococcus multilocularis para nitrobenzyl esterase 0.0014 0.002 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0191
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0026 0.0162 0.0193
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0272
Mycobacterium ulcerans esterase/lipase LipP 0.0115 0.1186 1
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0408 0.0411
Echinococcus multilocularis hypothetical protein 0.0019 0.0074 0.0074
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0049 0.0049
Echinococcus granulosus carboxylesterase 5A 0.0082 0.0803 0.0809
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0029 0.0191 0.0228
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0001 0.0002
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0674 0.2663
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.2205 0.4171
Brugia malayi Carboxylesterase family protein 0.0082 0.0803 0.152
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0027 0.0171 0.0204
Brugia malayi PHD-finger family protein 0.0034 0.0252 0.0476
Echinococcus multilocularis geminin 0.0874 0.993 0.993
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.1186 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0014 0.002 0.002
Echinococcus granulosus calpain 0.0019 0.0074 0.0075
Echinococcus multilocularis acetylcholinesterase 0.0082 0.0803 0.0803
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0049 0.087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.058 0.4881
Echinococcus multilocularis neuropeptide s receptor 0.0447 0.5006 0.5006
Loa Loa (eye worm) ctsf protein 0.0016 0.0049 0.0094
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0014 0.002 0.0023
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.0164 0.0643
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0053 0.0466 0.3924
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0027 0.0171 0.1298
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.0964 0.0971
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0027 0.0171 0.0324
Entamoeba histolytica hypothetical protein 0.0025 0.0144 0.2121
Onchocerca volvulus 0.0016 0.0049 0.0195
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0074 0.0615
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0191
Loa Loa (eye worm) hypothetical protein 0.0115 0.1186 0.2244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0191
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0074 0.0075
Schistosoma mansoni zinc finger protein 0.0018 0.0072 0.0072
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0261 0.0263
Loa Loa (eye worm) hypothetical protein 0.0082 0.0803 0.152
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.1595 0.1595
Mycobacterium ulcerans Type I modular polyketide synthase 0.0027 0.0171 0.1298
Toxoplasma gondii exonuclease III APE 0.006 0.0556 0.4684
Mycobacterium leprae Probable polyketide synthase Pks1 0.0029 0.0191 0.1112
Loa Loa (eye worm) hypothetical protein 0.0045 0.0383 0.0724
Mycobacterium ulcerans beta-lactamase 0.0115 0.1186 1
Echinococcus granulosus GPCR family 2 0.0096 0.0964 0.0971
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0049 0.0191
Brugia malayi Bromodomain containing protein 0.0094 0.0942 0.1782
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.0556 0.8246
Schistosoma mansoni hypothetical protein 0.0874 0.993 1
Echinococcus granulosus acetylcholinesterase 0.0082 0.0803 0.0809
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0074 0.0075
Loa Loa (eye worm) hypothetical protein 0.0082 0.0803 0.152
Loa Loa (eye worm) hypothetical protein 0.0096 0.0964 0.1823
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0026 0.0164 0.2415
Echinococcus multilocularis neuroligin 0.0014 0.002 0.002
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0197 0.1652
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0001 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0191
Schistosoma mansoni ap endonuclease 0.006 0.0556 0.056
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0164 0.0643
Brugia malayi Carboxylesterase family protein 0.0014 0.002 0.0038
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0303 0.3347 0.6331
Echinococcus granulosus acetylcholinesterase 0.0082 0.0803 0.0809
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0171 0.0204
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.058 0.4881
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0014 0.002 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.1186 0.4689
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.2158 0.2158
Echinococcus multilocularis BC026374 protein (S09 family) 0.0014 0.002 0.002
Echinococcus granulosus histone acetyltransferase KAT2B 0.0164 0.1754 0.1766
Leishmania major cathepsin L-like protease 0.0016 0.0049 0.0407
Brugia malayi Carboxylesterase family protein 0.0014 0.002 0.0038
Mycobacterium ulcerans polyketide synthase Pks9 0.0018 0.0066 0.0396
Echinococcus granulosus neuropeptide receptor A26 0.0447 0.5006 0.5041
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0272
Onchocerca volvulus Fatty acid synthase homolog 0.0049 0.0421 0.1664
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0014 0.002 0.002
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0074 0.0075
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0151 0.0286
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0049 0.0195
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0012 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0191
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.0964 0.1823
Loa Loa (eye worm) hypothetical protein 0.0175 0.1879 0.3554
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.058 0.4881
Onchocerca volvulus 0.0016 0.0049 0.0195
Entamoeba histolytica hypothetical protein 0.0025 0.0144 0.2121
Plasmodium vivax sphingomyelin synthase 1, putative 0.0025 0.0144 0.1204
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0303 0.3347 0.6331
Brugia malayi Glycosyl hydrolases family 31 protein 0.0318 0.3527 0.6672
Onchocerca volvulus 0.0115 0.1186 0.4691
Loa Loa (eye worm) hypothetical protein 0.0115 0.1186 0.2244
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0053 0.0466 0.184
Echinococcus granulosus calpain A 0.0065 0.0614 0.0618
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0001 0.0002
Onchocerca volvulus 0.0016 0.0049 0.0195
Echinococcus multilocularis neuropeptide receptor A26 0.0447 0.5006 0.5006
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0049 0.0195
Plasmodium vivax vivapain-2 0.0016 0.0049 0.0407
Echinococcus multilocularis neutral alpha glucosidase AB 0.0071 0.0674 0.0674
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0074 0.0075
Brugia malayi Pre-SET motif family protein 0.0029 0.0197 0.0373
Schistosoma mansoni ap endonuclease 0.006 0.0556 0.056
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0556 0.4684
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0001 0.0002
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0025 0.0144 0.0272
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0053 0.0466 0.3924
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0049 0.0191
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0027 0.0171 0.094
Echinococcus granulosus neuropeptide s receptor 0.0447 0.5006 0.5041
Schistosoma mansoni alpha-glucosidase 0.0274 0.3017 0.3038
Schistosoma mansoni synaptojanin 0.0012 0.0001 0.0001
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0025 0.0144 0.0272
Brugia malayi Latrophilin receptor protein 2 0.0096 0.0964 0.1823
Echinococcus granulosus cathepsin l1 0.0016 0.0049 0.005
Trichomonas vaginalis conserved hypothetical protein 0.017 0.1824 0.7211
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0065 0.0614 0.0618
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0356 0.0358
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0025 0.0144 0.0565
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0674 0.2663
Entamoeba histolytica hypothetical protein 0.0035 0.0261 0.386
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0674 0.2663
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0049 0.005
Plasmodium vivax hypothetical protein, conserved 0.0115 0.1186 1
Schistosoma mansoni hypothetical protein 0.0096 0.0964 0.0971
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0038
Entamoeba histolytica hypothetical protein 0.0025 0.0144 0.2121
Plasmodium falciparum histone acetyltransferase GCN5 0.0046 0.0386 0.693
Brugia malayi Sphingomyelin synthase-related 1 0.0025 0.0144 0.0272
Brugia malayi Glycosyl hydrolases family 31 protein 0.0071 0.0674 0.1276
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.058 0.4881
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0025 0.0151 0.018
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0356 0.0356
Schistosoma mansoni carbon catabolite repressor protein 0.0012 0.0001 0.0001
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0172 0.1841 0.1841
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0022 0.0111 0.0778
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0038
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0025 0.0144 0.0272
Leishmania major cathepsin L-like protease 0.0062 0.058 0.4881
Schistosoma mansoni hypothetical protein 0.0207 0.2244 0.226
Loa Loa (eye worm) acetylcholinesterase 1 0.0082 0.0803 0.152
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0484 0.0487
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0018 0.0062 0.0516
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0074 0.0615
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0025 0.0144 0.1204
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.0556 0.056
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.0964 0.0964
Schistosoma mansoni synaptojanin 0.0012 0.0001 0.0001
Loa Loa (eye worm) MBCTL1 0.0054 0.0484 0.0915
Onchocerca volvulus 0.0047 0.0402 0.1588
Echinococcus granulosus histone acetyltransferase KAT2B 0.0053 0.0466 0.047
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0029 0.0191 0.1112
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0074 0.0615
Entamoeba histolytica cysteine protease, putative 0.0016 0.0049 0.0717
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0025 0.0144 0.0272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.058 0.4881
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0018 0.014
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.7538 0.7538
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0025 0.0144 0.1204
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0001 0.0002
Entamoeba histolytica protein kinase, putative 0.0019 0.0074 0.1082
Echinococcus multilocularis calpain 5 0.0019 0.0074 0.0074
Onchocerca volvulus 0.0014 0.002 0.0079
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0022 0.0111 0.0778
Brugia malayi Cathepsin L-like precursor 0.0016 0.0049 0.0094
Plasmodium vivax sphingomyelin synthase 2, putative 0.0025 0.0144 0.1204
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0408 0.0408
Loa Loa (eye worm) fatty acid synthase 0.0027 0.0167 0.0316
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0025 0.0144 0.1204
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0049 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.1595 0.1606
Loa Loa (eye worm) carboxylesterase 0.0014 0.002 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.058 0.4881
Loa Loa (eye worm) hypothetical protein 0.005 0.0432 0.0817
Brugia malayi Cathepsin L-like precursor 0.0016 0.0049 0.0094
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0074 0.0615
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.1186 0.1195
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0484 0.0484
Schistosoma mansoni alpha glucosidase 0.0071 0.0674 0.0679
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0025 0.0144 0.1204
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0408 0.0408
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.1186 0.4689
Echinococcus granulosus geminin 0.0874 0.993 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0318 0.3527 0.3552
Echinococcus multilocularis cysteine protease 0.0016 0.0049 0.0049
Brugia malayi beta-lactamase family protein 0.0115 0.1186 0.2244
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0432 0.0435
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0074 0.0615
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0014 0.002 0.0075
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0145 0.0274
Toxoplasma gondii ABC1 family protein 0.0115 0.1186 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.0556 0.4684
Leishmania major cathepsin L-like protease 0.0016 0.0049 0.0407
Brugia malayi latrophilin 2 splice variant baaae 0.0207 0.2244 0.4244
Schistosoma mansoni hypothetical protein 0.0096 0.0964 0.0971
Brugia malayi Cathepsin L-like precursor 0.0016 0.0049 0.0094
Trypanosoma brucei ISWI complex protein 0.0018 0.0072 0.0594
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0029 0.0191 0.1464
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0281 0.2238
Brugia malayi Carboxylesterase family protein 0.0082 0.0803 0.152
Leishmania major cathepsin L-like protease 0.0016 0.0049 0.0407
Schistosoma mansoni bromodomain containing protein 0.008 0.078 0.0786
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0025 0.0144 0.2571
Onchocerca volvulus 0.0014 0.002 0.0079
Brugia malayi Pre-SET motif family protein 0.0204 0.2205 0.4171
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0281 0.1107
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0053 0.0466 0.3924
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0197 0.0198
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0556 0.2196
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0735 0.833 1
Echinococcus multilocularis traf and tnf receptor associated protein 0.0012 0.0001 0.0001
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0027 0.0171 0.0204
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0025 0.0144 0.0565
Onchocerca volvulus 0.0044 0.0364 0.144
Trypanosoma brucei hypothetical protein, conserved 0.0115 0.1186 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.006 0.0556 1
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0049 0.0407
Brugia malayi calpain family protein 1 0.0062 0.0577 0.1092
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.0964 0.1823
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0191
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0074 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0197 0.0198
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0049 0.0094
Brugia malayi calpain 7 0.0019 0.0074 0.014
Entamoeba histolytica hypothetical protein 0.0025 0.0144 0.2121
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0115 0.1186 0.1423
Echinococcus granulosus calpain 5 0.0019 0.0074 0.0075
Schistosoma mansoni calpain (C02 family) 0.0019 0.0074 0.0075
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0051 0.045 0.0851
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0484 0.0487
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0025 0.0144 0.0144
Echinococcus multilocularis deoxyribonuclease 1 2 0.0012 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0408 0.0772
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.058 0.4881
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0049 0.0094
Loa Loa (eye worm) carboxylesterase 0.0014 0.002 0.0038
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.0964 0.0971
Loa Loa (eye worm) calpain 0.0019 0.0074 0.014
Schistosoma mansoni spingomyelin synthetase-related 0.0025 0.0144 0.0145
Schistosoma mansoni inositol monophosphatase 0.0036 0.0281 0.0283
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0281 0.2361
Mycobacterium ulcerans hypothetical protein 0.0115 0.1186 1
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0025 0.0144 0.1204
Schistosoma mansoni hypothetical protein 0.0096 0.0964 0.0971
Loa Loa (eye worm) hypothetical protein 0.0053 0.047 0.0889
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0172 0.1841 0.1854
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0074 0.0615
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0191
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.0964 0.0964
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0071 0.0674 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0281 0.2361
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0164 0.0643
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0197 0.0197
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0025 0.0151 0.0286
Brugia malayi mbt repeat family protein 0.0048 0.0408 0.0772
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0065 0.0614 0.0618
Trichomonas vaginalis sucrase-isomaltase, putative 0.0071 0.0674 0.2663
Onchocerca volvulus 0.0016 0.0049 0.0195
Plasmodium vivax vivapain-2 0.0016 0.0049 0.0407
Loa Loa (eye worm) fibroinase 0.0016 0.0049 0.0094
Giardia lamblia Histone acetyltransferase GCN5 0.0046 0.0386 0.693
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0012 0.0001 0.0002
Mycobacterium ulcerans polyketide synthase 0.0027 0.0171 0.1298
Leishmania major alpha glucosidase II subunit, putative 0.0071 0.0674 0.568
Onchocerca volvulus 0.0012 0.0001 0.0005
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0014 0.002 0.002
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.004 0.0325 0.0389
Trichomonas vaginalis esterase, putative 0.0115 0.1186 0.4689
Loa Loa (eye worm) hypothetical protein 0.0471 0.5286 1
Echinococcus multilocularis calpain A 0.0065 0.0614 0.0614
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0074 0.0615
Echinococcus granulosus microtubule associated protein 2 0.0667 0.7538 0.7592
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0049 0.0407
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0674 0.2663
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0038
Schistosoma mansoni acetylcholinesterase 0.0014 0.002 0.002
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0731 0.0731
Echinococcus multilocularis acetylcholinesterase 0.0082 0.0803 0.0803
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0191
Entamoeba histolytica hypothetical protein 0.0035 0.0261 0.386
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0025 0.0144 0.0565
Schistosoma mansoni hypothetical protein 0.0301 0.3328 0.3352
Loa Loa (eye worm) hypothetical protein 0.0046 0.0389 0.0737
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0164 0.0643
Brugia malayi Calcitonin receptor-like protein seb-1 0.0303 0.3347 0.6331
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0096 0.0096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0191
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0115 0.1186 0.1423
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Entamoeba histolytica hypothetical protein 0.0035 0.0261 0.386
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0151 0.1595 0.3017
Mycobacterium leprae conserved hypothetical protein 0.0115 0.1186 1
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0026 0.0164 0.0648
Onchocerca volvulus 0.0012 0.0001 0.0005
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.0556 0.1052
Loa Loa (eye worm) acyl carrier protein 0.0012 0.0004 0.0007
Brugia malayi Carboxylesterase family protein 0.0014 0.002 0.0038
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0071 0.0674 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.004 0.0325 0.0389
Trypanosoma brucei kinesin, putative 0.0019 0.0074 0.0615
Mycobacterium leprae Probable lipase LipE 0.0115 0.1186 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.1595 0.1606
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0115 0.1186 0.1423
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0049 0.0191
Onchocerca volvulus 0.0029 0.0197 0.0779
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.1595 0.1606
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0484 0.0915
Echinococcus multilocularis synaptojanin 1 0.0012 0.0001 0.0001
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0049 0.0191
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.1186 0.4689
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0096 0.0096
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0408 0.0411
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0191
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0049 0.005
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.0556 0.1052
Plasmodium vivax SET domain protein, putative 0.0029 0.0197 0.1652
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0471 0.5286 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0014 0.002 0.002
Echinococcus multilocularis carboxylesterase 5A 0.0082 0.0803 0.0803
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0001 0.0002
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0432 0.0435
Loa Loa (eye worm) calpain family protein 1 0.0044 0.0364 0.0689
Trypanosoma cruzi kinesin, putative 0.0019 0.0074 0.0615
Leishmania major cathepsin L-like protease 0.0062 0.058 0.4881
Mycobacterium tuberculosis Probable esterase LipL 0.0115 0.1186 0.1423
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0175 0.1879 0.3554
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.0084 0.0099
Loa Loa (eye worm) calpain family protein 1 0.0062 0.0577 0.1092
Loa Loa (eye worm) acetyltransferase 0.0172 0.1841 0.3483
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.1595 0.1595
Trypanosoma brucei antigen, putative 0.0019 0.0074 0.0615
Mycobacterium tuberculosis Carboxylesterase LipT 0.0014 0.002 0.0023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0049 0.0191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.058 0.4881
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0517 0.4355
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0062 0.0577 0.0582
Loa Loa (eye worm) inositol-1 0.0036 0.0281 0.0532
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0001 0.0002
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0026 0.0164 0.1372
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0049 0.0717
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0261 0.0263
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0029 0.0191 0.1464
Loa Loa (eye worm) calpain 5 0.0019 0.0074 0.014
Toxoplasma gondii hypothetical protein 0.0025 0.0144 0.1204
Mycobacterium leprae Polyketide synthase Pks13 0.004 0.0325 0.2311
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0484 0.0484
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0281 0.2361
Echinococcus granulosus zinc finger protein 0.0028 0.0178 0.0179
Echinococcus multilocularis cysteine protease 0.0016 0.0049 0.0049
Brugia malayi CCR4 0.0012 0.0001 0.0002
Trypanosoma cruzi ISWI complex protein 0.0018 0.0072 0.0594
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0272
Trichomonas vaginalis set domain proteins, putative 0.0232 0.2529 1
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0674 0.568
Echinococcus granulosus neutral alpha glucosidase AB 0.0071 0.0674 0.0679
Onchocerca volvulus 0.0048 0.0408 0.1613
Schistosoma mansoni nocturnin 0.0012 0.0001 0.0001
Brugia malayi beta-lactamase 0.0115 0.1186 0.2244
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0281 0.0283
Mycobacterium tuberculosis Conserved protein 0.0115 0.1186 0.1423
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.1595 0.1606
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.058 0.4881
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0272
Brugia malayi Cathepsin L-like precursor 0.0016 0.0049 0.0094
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0281 0.0281
Brugia malayi Carboxylesterase family protein 0.0014 0.002 0.0038
Echinococcus granulosus synaptojanin 1 0.0012 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0049 0.0191
Mycobacterium ulcerans Type I modular polyketide synthase 0.0027 0.0171 0.1298
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0022 0.0111 0.0398
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0022 0.0115 0.0136
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0026 0.0162 0.0193
Trichomonas vaginalis spcc417.12 protein, putative 0.0014 0.002 0.0075
Trichomonas vaginalis bromodomain-containing protein, putative 0.0053 0.0466 0.184
Brugia malayi calpain 5 0.0019 0.0074 0.014
Mycobacterium ulcerans thioesterase 0.0022 0.012 0.0854
Loa Loa (eye worm) hypothetical protein 0.0115 0.1186 0.2244
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0015 0.0037 0.0043
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0426 0.3583
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0066
Loa Loa (eye worm) hypothetical protein 0.0062 0.0577 0.1092
Trichomonas vaginalis hypothetical protein 0.0025 0.0144 0.0565
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0025 0.0144 0.2571
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0071 0.0674 0.568
Loa Loa (eye worm) hypothetical protein 0.0044 0.0364 0.0689
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0049 0.0717
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0191
Schistosoma mansoni hypothetical protein 0.0035 0.0261 0.0263
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0074 0.0615
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0408 0.0411
Plasmodium vivax calpain, putative 0.0019 0.0074 0.0615
Entamoeba histolytica hypothetical protein 0.0025 0.0144 0.2121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.058 0.4881
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.0556 0.4684
Brugia malayi calpain family protein 1 0.0062 0.0577 0.1092
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0185 0.0186
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.0556 0.4684
Brugia malayi Inositol-1 0.0036 0.0281 0.0532
Schistosoma mansoni hypothetical protein 0.0874 0.993 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.058 0.4881
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0022 0.012 0.0477
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.0556 0.0556
Mycobacterium tuberculosis Probable lipase LipD 0.0115 0.1186 0.1423
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0171 0.0173
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0074 0.0615
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.7538 0.7592
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.058 0.4881
Mycobacterium ulcerans lipase LipD 0.0115 0.1186 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0049 0.0049
Leishmania major kinesin, putative 0.0019 0.0074 0.0615
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0144 0.0565
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0001 0.0002
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0065 0.0614 0.0618
Entamoeba histolytica hypothetical membrane-spanning protein 0.0025 0.0144 0.2121
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0237 0.1525
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0014 0.002 0.002
Mycobacterium tuberculosis Conserved protein 0.0115 0.1186 0.1423
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0074 0.0615
Echinococcus granulosus neuroligin 0.0014 0.002 0.002
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.006 0.0556 1
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0065 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0044 0.0364 0.0689
Loa Loa (eye worm) hypothetical protein 0.0054 0.0484 0.0915
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0115 0.1186 0.2244
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0074 0.0615
Onchocerca volvulus 0.0014 0.002 0.0079
Onchocerca volvulus 0.0016 0.0049 0.0195
Brugia malayi acetyltransferase, GNAT family protein 0.0172 0.1841 0.3483
Mycobacterium tuberculosis Conserved protein 0.0115 0.1186 0.1423
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.058 0.4881
Echinococcus multilocularis lysosomal alpha glucosidase 0.0318 0.3527 0.3527
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0038
Leishmania major hypothetical protein, conserved 0.0018 0.0072 0.0594
Leishmania major cathepsin L-like protease 0.0062 0.058 0.4881
Echinococcus granulosus para nitrobenzyl esterase 0.0014 0.002 0.002
Echinococcus granulosus beta LACTamase domain containing family member 0.0115 0.1186 0.1195
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.058 0.4881
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0012 0.0001 0.0001
Leishmania major glycosyl hydrolase-like protein 0.0026 0.0164 0.1372
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.2158 0.2173
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0029 0.0191 0.0228
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.006 0.0556 0.4598
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0038
Echinococcus multilocularis GPCR, family 2 0.0096 0.0964 0.0964
Schistosoma mansoni hypothetical protein 0.0018 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0049 0.0191
Echinococcus granulosus neutral sphingomyelinase 0.0012 0.0001 0.0001
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0001 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.1595 0.1606
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0074 0.0615
Entamoeba histolytica hypothetical protein 0.0035 0.0261 0.386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0049 0.0191
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0674 0.568
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0074 0.0615

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) Inhibition of human recombinant AChE by modified Ellman's spectrophotometric method ChEMBL. 20181484
Ki (binding) = 0.31 uM Inhibition of human plasma BuChE by modified Ellman's spectrophotometric method ChEMBL. 20181484

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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