Detailed information for compound 1024253

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 365.43 | Formula: C23H19N5
  • H donors: 2 H acceptors: 2 LogP: 4.63 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc2c(cccc2c2c1nn(c2)c1ccccc1)NCc1ccccc1
  • InChi: 1S/C23H19N5/c24-23-22-19(15-28(27-22)17-10-5-2-6-11-17)18-12-7-13-20(21(18)26-23)25-14-16-8-3-1-4-9-16/h1-13,15,25H,14H2,(H2,24,26)
  • InChiKey: STNHPPUKBIEADN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein adenosine A1 receptor 326 aa 305 aa 21.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0202 0.1081 0.1226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0217 0.0244
Leishmania major peptidylprolyl isomerase-like protein 0.0218 0.1183 0.426
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0064 0.0209 0.0203
Giardia lamblia Cathepsin L precursor 0.0046 0.0094 0.0276
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0188 0.0993 0.1136
Brugia malayi Cathepsin L-like precursor 0.0057 0.0162 0.018
Schistosoma mansoni hypothetical protein 0.0068 0.0229 0.0257
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0209 0.022
Echinococcus multilocularis neuropeptide receptor A26 0.0493 0.2925 0.2921
Trichomonas vaginalis calmodulin, putative 0.0078 0.0297 0.1019
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0092
Brugia malayi cathepsin Z-like cysteine proteinase 0.0046 0.0094 0.0101
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0209 0.0699
Loa Loa (eye worm) cathepsin B 0.0466 0.2753 0.3167
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0046 0.0094 0.0648
Schistosoma mansoni immunophilin 0.0218 0.1183 0.1355
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0046 0.0094 0.0276
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0034 0.0018 0.0014
Schistosoma mansoni calpain-7 (C02 family) 0.0202 0.1081 0.1238
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0253 0.086
Leishmania major cathepsin L-like protease 0.0064 0.0209 0.0699
Schistosoma mansoni chromobox protein 0.0071 0.0253 0.0285
Brugia malayi chromobox protein homolog 3 0.004 0.0055 0.0056
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0218 0.1183 0.426
Brugia malayi Calmodulin-like protein 0.0034 0.0018 0.0014
Schistosoma mansoni mitochondrial solute carrier 0.0034 0.0018 0.0014
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0098 0.0092
Entamoeba histolytica calpain family cysteine protease, putative 0.0061 0.0186 0.1443
Echinococcus granulosus calcium uptake protein 1 0.0034 0.0018 0.0014
Onchocerca volvulus 0.0109 0.0495 0.2586
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Plasmodium falciparum serine repeat antigen 4 0.0046 0.0094 0.0648
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0186 0.0194
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0264 0.0297
Schistosoma mansoni centrin 0.0034 0.0018 0.0014
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0466 0.2753 0.3153
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0202 0.1081 0.3888
Echinococcus multilocularis programmed cell death protein 0.0078 0.0297 0.0291
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0046 0.0094 0.0276
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Echinococcus granulosus cathepsin L 0.0046 0.0094 0.0101
Giardia lamblia Encystation-specific protease 0.0046 0.0094 0.0276
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0218 0.1183 0.1355
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0055 0.0134
Onchocerca volvulus 0.0046 0.0094 0.0489
Schistosoma mansoni immunophilin 0.0218 0.1183 0.1355
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0132 0.0416
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0218 0.1183 0.426
Plasmodium falciparum serine repeat antigen 7 0.0046 0.0094 0.0648
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0202 0.1081 0.1226
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0094 0.0276
Plasmodium falciparum centrin-4 0.0044 0.008 0.0534
Plasmodium falciparum serine repeat antigen 9 0.0046 0.0094 0.0648
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0061 0.0186 0.0194
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0132 0.0416
Echinococcus multilocularis expressed conserved protein 0.0096 0.0409 0.0403
Trichomonas vaginalis centrin, putative 0.0044 0.008 0.0227
Loa Loa (eye worm) hypothetical protein 0.0109 0.0495 0.057
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0034 0.0018 0.0012
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.0725 0.0828
Brugia malayi Cathepsin L-like precursor 0.0057 0.0162 0.018
Trypanosoma cruzi major cysteine proteinase, putative 0.0046 0.0094 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Brugia malayi Cathepsin L-like precursor 0.0064 0.0209 0.0234
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.0495 0.0563
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0132 0.0131
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0061 0.0186 0.0615
Echinococcus granulosus cathepsin L cysteine protease 0.0054 0.014 0.0155
Loa Loa (eye worm) hypothetical protein 0.0046 0.0094 0.0108
Brugia malayi beta-lactamase 0.0109 0.0495 0.0563
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0264 0.0297
Giardia lamblia Cysteine protease 0.0046 0.0094 0.0276
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0132 0.0126
Loa Loa (eye worm) hypothetical protein 0.0057 0.0162 0.0187
Plasmodium vivax vivapain-2 0.0064 0.0209 0.1641
Echinococcus multilocularis chromobox protein 1 0.0071 0.0253 0.0247
Brugia malayi Calcitonin receptor-like protein seb-1 0.0213 0.1154 0.1322
Entamoeba histolytica hypothetical protein 0.0046 0.0094 0.0648
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.0094 0.0101
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0218 0.1183 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.014 0.0447
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0194
Echinococcus multilocularis calpain 5 0.0202 0.1081 0.1076
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0079 0.0091
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0699 0.4232 1
Schistosoma mansoni hypothetical protein 0.0068 0.0229 0.0257
Loa Loa (eye worm) hypothetical protein 0.0213 0.1154 0.1328
Entamoeba histolytica cysteine protease, putative 0.0046 0.0094 0.0648
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0218 0.1183 1
Onchocerca volvulus 0.0032 0.0006 0.0031
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0055 0.0286
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0186 0.0615
Brugia malayi calcium-binding protein 0.0034 0.0018 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.014 0.0447
Schistosoma mansoni neuronal calcium sensor 0.0034 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0046 0.0094 0.0108
Loa Loa (eye worm) calpain 5 0.0141 0.0697 0.0801
Loa Loa (eye worm) hypothetical protein 0.0032 0.0006 0.0007
Giardia lamblia Hypothetical protein 0.0046 0.0094 0.0276
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0218 0.1183 0.1355
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0217 0.0244
Echinococcus multilocularis fk506 binding protein 0.0218 0.1183 0.1178
Brugia malayi Probable myosin regulatory light chain 0.0044 0.008 0.0086
Plasmodium vivax vivapain-2 0.0064 0.0209 0.1641
Onchocerca volvulus 0.0064 0.0209 0.1093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Trichomonas vaginalis calmodulin, putative 0.0044 0.008 0.0227
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.057 0.3411 0.3407
Loa Loa (eye worm) hypothetical protein 0.0046 0.0094 0.0108
Loa Loa (eye worm) hypothetical protein 0.0146 0.0726 0.0835
Leishmania major fk506-binding protein 1-like protein 0.0218 0.1183 0.426
Brugia malayi calpain 5 0.0061 0.0186 0.0208
Schistosoma mansoni hypothetical protein 0.0068 0.0229 0.0257
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0094 0.0276
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.0495 0.0563
Echinococcus granulosus calpain 0.0202 0.1081 0.1238
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0218 0.1183 0.1343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.014 0.0447
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0209 0.0699
Brugia malayi calpain 7 0.0202 0.1081 0.1238
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0218 0.1183 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0495 0.0563
Echinococcus granulosus chromobox protein 1 0.0071 0.0253 0.0285
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0098 0.0106
Echinococcus multilocularis calpain 0.0202 0.1081 0.1076
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0466 0.2753 1
Brugia malayi Papain family cysteine protease containing protein 0.0064 0.0209 0.0234
Loa Loa (eye worm) hypothetical protein 0.0046 0.0094 0.0108
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.014 0.0155
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1403 0.8691 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0162 0.0527
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0218 0.1183 0.1355
Toxoplasma gondii ABC1 family protein 0.0109 0.0495 0.1744
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0448 0.0509
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0046 0.0094 0.0276
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.0044 0.008 0.0419
Brugia malayi programmed cell death protein 6 0.0034 0.0018 0.0014
Brugia malayi cathepsin L-like cysteine proteinase 0.0046 0.0094 0.0101
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0046 0.0094 0.0648
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0217 0.025
Echinococcus multilocularis calbindin 32 0.0034 0.0018 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Giardia lamblia Cathepsin L precursor 0.0046 0.0094 0.0276
Brugia malayi calpain family protein 1 0.0536 0.3194 0.3671
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0094 0.0276
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0094 0.0101
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0218 0.1183 0.1361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0094 0.0276
Echinococcus granulosus cathepsin b 0.1403 0.8691 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0046 0.0094 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Loa Loa (eye worm) hypothetical protein 0.0061 0.0186 0.0214
Toxoplasma gondii cathepsin CPC1 0.0046 0.0094 0.0276
Leishmania major cathepsin L-like protease 0.0064 0.0209 0.0699
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0202 0.1081 0.1226
Leishmania major kinesin, putative 0.0141 0.0697 0.2481
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0213 0.1154 0.1322
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0218 0.1183 0.426
Schistosoma mansoni centrin-related 0.0034 0.0018 0.0014
Toxoplasma gondii centrin family protein 0.0044 0.008 0.0227
Plasmodium vivax serine-repeat antigen (SERA) 0.0046 0.0094 0.0648
Entamoeba histolytica cysteine protease, putative 0.0046 0.0094 0.0648
Onchocerca volvulus 0.0109 0.0495 0.2586
Schistosoma mansoni rab 0.0034 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0109 0.0495 0.057
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0209 0.022
Entamoeba histolytica calmodulin, putative 0.0044 0.008 0.0534
Echinococcus granulosus chromobox protein 1 0.0071 0.0253 0.0285
Echinococcus multilocularis calpain A 0.057 0.3411 0.3407
Loa Loa (eye worm) hypothetical protein 0.0054 0.0141 0.0163
Trichomonas vaginalis calcium binding protein, putative 0.0078 0.0297 0.1019
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0217 0.0244
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0218 0.1183 0.1343
Onchocerca volvulus Cathepsin L homolog 0.0064 0.0209 0.1093
Giardia lamblia Cathepsin L-like protease 0.0046 0.0094 0.0276
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Echinococcus multilocularis hypothetical protein 0.0202 0.1081 0.1076
Loa Loa (eye worm) myosin regulatory light chain 1 0.0044 0.008 0.0092
Echinococcus multilocularis GPCR, family 2 0.0068 0.0229 0.0224
Toxoplasma gondii cathepsin CPC2 0.0046 0.0094 0.0276
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0046 0.0094 0.0101
Schistosoma mansoni hypothetical protein 0.0061 0.0186 0.0208
Echinococcus granulosus calpain A 0.0202 0.1081 0.1238
Loa Loa (eye worm) hypothetical protein 0.0475 0.281 0.3233
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0186 0.0194
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0061 0.0186 0.0615
Echinococcus granulosus cathepsin l cysteine peptidase 0.0064 0.0209 0.0234
Schistosoma mansoni myosin regulatory light chain 0.0044 0.008 0.0086
Echinococcus multilocularis chromobox protein 1 0.0071 0.0253 0.0247
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0132 0.0126
Loa Loa (eye worm) hypothetical protein 0.0034 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0148 0.074 0.0852
Schistosoma mansoni hypothetical protein 0.0526 0.3136 0.3603
Plasmodium falciparum calpain 0.0061 0.0186 0.1443
Brugia malayi EF hand family protein 0.0034 0.0018 0.0014
Schistosoma mansoni chromobox protein 0.0071 0.0253 0.0285
Schistosoma mansoni hypothetical protein 0.0146 0.0726 0.0829
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.0495 0.057
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0186 0.0194
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Entamoeba histolytica cysteine protease, putative 0.0064 0.0209 0.1641
Loa Loa (eye worm) hypothetical protein 0.0046 0.0094 0.0108
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0194
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0132 0.0145
Onchocerca volvulus 0.0044 0.008 0.0419
Echinococcus granulosus neurocalcin 0.0034 0.0018 0.0014
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0035 0.0021 0.0026
Giardia lamblia Cathepsin B precursor 0.0046 0.0094 0.0276
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0068 0.0229 0.0257
Toxoplasma gondii calmodulin, putative 0.0044 0.008 0.0227
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0188 0.0993 0.0988
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0218 0.1183 0.1178
Schistosoma mansoni hypothetical protein 0.0073 0.0264 0.0297
Leishmania major cathepsin L-like protease 0.0064 0.0209 0.0699
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0218 0.1183 0.5
Trypanosoma brucei cysteine peptidase, putative 0.0061 0.0186 0.0615
Toxoplasma gondii calcium binding protein precursor, putative 0.0044 0.008 0.0227
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.014 0.105
Trypanosoma cruzi cysteine protease, putative 0.0054 0.014 0.0141
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0202 0.1081 0.1226
Echinococcus granulosus neuropeptide receptor A26 0.0493 0.2925 0.3361
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0035 0.0021 0.0003
Schistosoma mansoni calmodulin 0.0034 0.0018 0.0014
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0218 0.1183 0.1343
Echinococcus granulosus geminin 0.0526 0.3136 0.3603
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0074 0.0204
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0253 0.0291
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.057 0.3411 0.392
Brugia malayi Latrophilin receptor protein 2 0.0068 0.0229 0.0257
Schistosoma mansoni immunophilin 0.0188 0.0993 0.1136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0079 0.0084
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0466 0.2753 0.3162
Echinococcus granulosus calpain 5 0.0202 0.1081 0.1238
Trypanosoma cruzi centrin-3 0.0078 0.0297 0.0321
Brugia malayi calpain family protein 1 0.0536 0.3194 0.3671
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Echinococcus multilocularis cathepsin L cysteine protease 0.0064 0.0209 0.0203
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0209 0.0699
Trypanosoma brucei kinesin, putative 0.0141 0.0697 0.2481
Brugia malayi Cathepsin L-like cysteine proteinase 0.0057 0.0162 0.018
Echinococcus granulosus calumenin 0.0034 0.0018 0.0014
Onchocerca volvulus Cathepsin F homolog 0.0064 0.0209 0.1093
Toxoplasma gondii calcium-dependent protein kinase 0.0035 0.0021 0.0011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1403 0.8691 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0046 0.0094 0.0648
Entamoeba histolytica cysteine protease, putative 0.0046 0.0094 0.0648
Trichomonas vaginalis calcium binding protein, putative 0.0044 0.008 0.0227
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0202 0.1081 0.1226
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0094 0.0276
Echinococcus multilocularis cysteine protease 0.0064 0.0209 0.0203
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0092
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0218 0.1183 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0054 0.014 0.105
Trypanosoma cruzi centrin, putative 0.0078 0.0297 0.0321
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0495 0.1744
Plasmodium vivax vivapain-1 0.0054 0.014 0.105
Loa Loa (eye worm) hypothetical protein 0.0109 0.0495 0.057
Brugia malayi cathepsin Z-like cysteine proteinase 0.0046 0.0094 0.0101
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0466 0.2753 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0046 0.0094 0.0101
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0064 0.0209 0.0241
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0132 0.0416
Leishmania major cathepsin L-like protease 0.0064 0.0209 0.0699
Loa Loa (eye worm) hypothetical protein 0.0044 0.0079 0.0091
Plasmodium vivax vivapain-3 0.0054 0.014 0.105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Schistosoma mansoni Mername-AA248 (C02 family) 0.0202 0.1081 0.1238
Loa Loa (eye worm) hypothetical protein 0.0032 0.0002 0.0003
Echinococcus granulosus Myosin regulatory light chain 0.0044 0.008 0.0086
Echinococcus granulosus programmed cell death protein 0.0078 0.0297 0.0335
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0132 0.0131
Brugia malayi Cathepsin L-like precursor 0.0064 0.0209 0.0234
Echinococcus multilocularis calmodulin 0.0034 0.0018 0.0012
Trypanosoma brucei calpain-like protein, putative 0.0202 0.1081 0.3888
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.057 0.3411 0.392
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0213 0.1154 0.1328
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0202 0.1081 0.3888
Onchocerca volvulus 0.0032 0.0006 0.0031
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0006 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0098 0.0106
Echinococcus granulosus cysteine protease 0.0054 0.014 0.0155
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.014 0.0141
Toxoplasma gondii hypothetical protein 0.0061 0.0186 0.0615
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0046 0.0094 0.0101
Echinococcus multilocularis calmodulin 0.0034 0.0018 0.0012
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0448 0.0509
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Leishmania major cysteine peptidase A (CPA) 0.0064 0.0209 0.0699
Trichomonas vaginalis hypothetical protein 0.0061 0.0186 0.0615
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Schistosoma mansoni cathepsin F (C01 family) 0.0064 0.0209 0.0234
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Loa Loa (eye worm) hypothetical protein 0.0109 0.0495 0.057
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0074 0.0204
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0054 0.014 0.0155
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0186 0.0615
Trypanosoma brucei Calpain-like protein 2 0.0061 0.0186 0.0615
Schistosoma mansoni neuronal calcium sensor 0.0034 0.0018 0.0014
Schistosoma mansoni hypothetical protein 0.0526 0.3136 0.3603
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0046 0.0094 0.0276
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0218 0.1183 1
Schistosoma mansoni calpain-7 (C02 family) 0.0202 0.1081 0.1238
Plasmodium vivax serine-repeat antigen (SERA) 0.0046 0.0094 0.0648
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0034 0.0018 0.0012
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0253 0.086
Entamoeba histolytica cysteine proteinase, putative 0.0057 0.0162 0.1238
Giardia lamblia Programmed cell death protein-like protein 0.0044 0.008 0.0227
Echinococcus multilocularis centrin 2 0.0034 0.0018 0.0012
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0186 0.0615
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0094 0.0276
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0495 0.1744
Trypanosoma brucei Calpain-like protein 1.1 0.0061 0.0186 0.0615
Onchocerca volvulus Cathepsin L homolog 0.0064 0.0209 0.1093
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0046 0.0094 0.0101
Loa Loa (eye worm) hypothetical protein 0.0064 0.0209 0.0241
Schistosoma mansoni neuronal calcium sensor 0.0034 0.0018 0.0014
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.0094 0.0101
Trypanosoma brucei Calpain-like protein CALP1.3 0.0061 0.0186 0.0615
Trypanosoma brucei calpain-like protein, putative 0.0202 0.1081 0.3888
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1403 0.8691 1
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.0044 0.008 0.0227
Trypanosoma brucei calpain, putative 0.0061 0.0186 0.0615
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0006 0.0007
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0046 0.0094 0.0108
Toxoplasma gondii calmodulin CAM2 0.0044 0.008 0.0227
Leishmania major calpain protease-like protein 0.0061 0.0186 0.0615
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0094 0.0101
Leishmania major cathepsin L-like protease 0.0064 0.0209 0.0699
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0132 0.0416
Onchocerca volvulus 0.0064 0.0209 0.1093
Entamoeba histolytica hypothetical protein 0.0073 0.0264 0.2108
Entamoeba histolytica hypothetical protein 0.0073 0.0264 0.2108
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0218 0.1183 0.426
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.008 0.0227
Loa Loa (eye worm) hypothetical protein 0.0057 0.0162 0.0187
Schistosoma mansoni cathepsin F (C01 family) 0.0057 0.0162 0.018
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0202 0.1081 0.3888
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0209 0.022
Trypanosoma brucei hypothetical protein 0.0061 0.0186 0.0615
Onchocerca volvulus 0.0064 0.0209 0.1093
Trypanosoma cruzi kinesin, putative 0.0141 0.0697 0.0782
Loa Loa (eye worm) calpain family protein 1 0.0394 0.2299 0.2645
Trichomonas vaginalis centrin, putative 0.0044 0.008 0.0227
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0094 0.0276
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0046 0.0094 0.0276
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0264 0.0258
Echinococcus multilocularis protein patched 0.0044 0.0079 0.0073
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0132 0.0416
Trichomonas vaginalis calpain, putative 0.0061 0.0186 0.0615
Onchocerca volvulus 0.0148 0.074 0.3866
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0046 0.0094 0.0648
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0046 0.0094 0.0648
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0068 0.0229 0.0224
Trichomonas vaginalis calpain, putative 0.0061 0.0186 0.0615
Entamoeba histolytica cysteine proteinase, putative 0.0064 0.0209 0.1641
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0094 0.0101
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0064 0.0209 0.0241
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0218 0.1183 0.426
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0094 0.0276
Leishmania major cathepsin L-like protease 0.0064 0.0209 0.0699
Giardia lamblia Cathepsin B precursor 0.0466 0.2753 1
Trypanosoma brucei caltractin, putative 0.0078 0.0297 0.1019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Echinococcus granulosus neuronal calcium sensor 0.0034 0.0018 0.0014
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0218 0.1183 0.426
Echinococcus multilocularis calpain 7 (C02 family) 0.0202 0.1081 0.1076
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0034 0.0018 0.0014
Echinococcus multilocularis calcyphosin protein 0.0044 0.008 0.0074
Schistosoma mansoni hypothetical protein 0.0042 0.0069 0.0072
Schistosoma mansoni calpain C (C02 family) 0.0202 0.1081 0.1238
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0218 0.1183 0.1355
Echinococcus multilocularis calpain family protein 1, d 0.0394 0.2299 0.2295
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0202 0.1081 0.1226
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0495 0.1744
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0068 0.0229 0.0257
Loa Loa (eye worm) latrophilin receptor protein 2 0.0068 0.0229 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0079 0.0222
Giardia lamblia Cathepsin L-like protease 0.0046 0.0094 0.0276
Schistosoma mansoni cathepsin F (C01 family) 0.0064 0.0209 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0064 0.0209 0.0699
Onchocerca volvulus 0.0034 0.0018 0.0095
Trichomonas vaginalis calpain, putative 0.0061 0.0186 0.0615
Brugia malayi cathepsin L-like precursor 0.0057 0.0162 0.018
Echinococcus granulosus GPCR family 2 0.0068 0.0229 0.0257
Giardia lamblia Calmodulin 0.0044 0.008 0.0227
Brugia malayi hypothetical protein 0.0148 0.074 0.0845
Echinococcus multilocularis calcium uptake protein 1 0.0034 0.0018 0.0012
Brugia malayi calpain 5 0.0141 0.0697 0.0795
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0132 0.0131
Trypanosoma brucei cysteine peptidase C (CPC) 0.0466 0.2753 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.057 0.3411 0.392
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0094 0.0276
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0202 0.1081 0.1226
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0054 0.014 0.0141
Giardia lamblia Cathepsin B precursor 0.0046 0.0094 0.0276
Schistosoma mansoni hypothetical protein 0.0068 0.0229 0.0257
Giardia lamblia Cathepsin B precursor 0.0046 0.0094 0.0276
Echinococcus multilocularis cathepsin b 0.1403 0.8691 0.8691
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0094 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0094 0.0276
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1403 0.8691 1
Leishmania major hypothetical protein, unknown function 0.0061 0.0186 0.0615
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0094 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Schistosoma mansoni myosin regulatory light chain 0.0044 0.008 0.0086
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0054 0.014 0.0155
Echinococcus granulosus programmed cell death protein 6 0.0044 0.008 0.0086
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.0458 0.052
Leishmania major protein kinase, putative 0.0035 0.0021 0.0011
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0079 0.0084
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0061 0.0186 0.0194
Echinococcus multilocularis protein dispatched 1 0.005 0.0118 0.0112
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0209 0.0699
Brugia malayi beta-lactamase family protein 0.0109 0.0495 0.0563
Leishmania major calpain family cysteine protease-like protein 0.0061 0.0186 0.0615
Mycobacterium leprae Probable lipase LipE 0.0109 0.0495 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.0018 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0209 0.0699
Mycobacterium leprae conserved hypothetical protein 0.0109 0.0495 0.5
Giardia lamblia Cathepsin L precursor 0.0046 0.0094 0.0276
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0536 0.3194 0.3671
Schistosoma mansoni hypothetical protein 0.0042 0.0069 0.0072
Entamoeba histolytica grainin 2 0.0044 0.008 0.0534
Giardia lamblia Hypothetical protein 0.0046 0.0094 0.0276
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0035 0.0021 0.0011
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0092
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0094 0.0276
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.0725 0.072
Echinococcus multilocularis neuropeptide s receptor 0.0493 0.2925 0.2921
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0132 0.0131
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0068 0.0229 0.0224
Loa Loa (eye worm) hypothetical protein 0.0109 0.0495 0.057
Loa Loa (eye worm) calpain family protein 1 0.0536 0.3194 0.3675
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.0094 0.0101
Brugia malayi Cathepsin L-like precursor 0.0064 0.0209 0.0234
Trypanosoma cruzi cysteine proteinase, putative 0.0054 0.014 0.0141
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0448 0.369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0202 0.1081 0.1226
Brugia malayi Cathepsin L-like precursor 0.0064 0.0209 0.0234
Trypanosoma brucei Calpain-like protein 1.2 0.0061 0.0186 0.0615
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0046 0.0094 0.0276
Onchocerca volvulus 0.0064 0.0209 0.1093
Echinococcus multilocularis cathepsin L 0.0054 0.014 0.0135
Loa Loa (eye worm) hypothetical protein 0.0068 0.0229 0.0264
Echinococcus granulosus tar DNA binding protein 0.0066 0.0217 0.0244
Trypanosoma brucei calpain, putative 0.0061 0.0186 0.0615
Loa Loa (eye worm) calpain 0.0202 0.1081 0.1244
Loa Loa (eye worm) hypothetical protein 0.0102 0.0448 0.0515
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0495 0.1744
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0094 0.0101
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0098 0.0106
Onchocerca volvulus 0.0034 0.0018 0.0095
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0132 0.0145
Schistosoma mansoni hypothetical protein 0.0042 0.0069 0.0072
Trypanosoma brucei calpain-like protein, putative 0.0202 0.1081 0.3888
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0209 0.0699
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0046 0.0094 0.0648
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0217 0.0212
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0194
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0132 0.0416
Giardia lamblia Cathepsin B precursor 0.0466 0.2753 1
Echinococcus granulosus calbindin 32 0.0034 0.0018 0.0014
Echinococcus multilocularis cathepsin L 0.0046 0.0094 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Trypanosoma cruzi kinesin, putative 0.0141 0.0697 0.0782
Echinococcus multilocularis cathepsin b 0.1403 0.8691 0.8691
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0217 0.0244
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0046 0.0094 0.0276
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Brugia malayi Neuronal calcium sensor family protein 1 0.0044 0.008 0.0086
Leishmania major cathepsin L-like protease 0.0064 0.0209 0.0699
Trypanosoma brucei calpain-like protein, putative 0.0202 0.1081 0.3888
Loa Loa (eye worm) FKBP5 protein 0.0218 0.1183 0.1361
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0186 0.0615
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0495 0.0563
Schistosoma mansoni myosin light chain 0.0044 0.008 0.0086
Brugia malayi CHE-14 protein 0.0044 0.0079 0.0084
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0217 0.025
Echinococcus multilocularis neurocalcin 0.0034 0.0018 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0217 0.0244
Echinococcus granulosus expressed conserved protein 0.0096 0.0409 0.0464
Plasmodium falciparum cysteine proteinase falcipain 3 0.0064 0.0209 0.1641
Trypanosoma cruzi centrin, putative 0.0078 0.0297 0.0321
Trichomonas vaginalis esterase, putative 0.0109 0.0495 0.1744
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0094 0.0276
Schistosoma mansoni calmodulin-related 0.0044 0.008 0.0086
Echinococcus multilocularis neuronal calcium sensor 0.0034 0.0018 0.0012
Entamoeba histolytica cysteine protease, putative 0.0046 0.0094 0.0648
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0186 0.0194
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1403 0.8691 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0495 0.057
Giardia lamblia Cathepsin L precursor 0.0046 0.0094 0.0276
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0064 0.0209 0.1641
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0209 0.022
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0186 0.0615
Echinococcus multilocularis EF hand domain containing family member A2 0.0034 0.0018 0.0012
Echinococcus granulosus cathepsin L cysteine proteinase 0.0064 0.0209 0.0234
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0035 0.0021 0.0003
Trichomonas vaginalis immunophilin, putative 0.0218 0.1183 0.426
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.014 0.105
Schistosoma mansoni hypothetical protein 0.0034 0.0018 0.0014
Schistosoma mansoni calpain-2 (C02 family) 0.0061 0.0186 0.0208
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0046 0.0094 0.0108
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0186 0.0615
Brugia malayi RNA binding protein 0.0066 0.0217 0.0244
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0209 0.0699
Trichomonas vaginalis fk506-binding protein, putative 0.0218 0.1183 0.426
Giardia lamblia Cathepsin L precursor 0.0046 0.0094 0.0276
Giardia lamblia Cathepsin B precursor 0.0046 0.0094 0.0276
Echinococcus multilocularis cathepsin L cysteine protease 0.0064 0.0209 0.0203
Trypanosoma cruzi conserved protein 0.0061 0.0186 0.0194
Brugia malayi cathepsin B-like cysteine proteinase 0.1403 0.8691 1
Toxoplasma gondii EF hand domain-containing protein 0.0044 0.008 0.0227
Loa Loa (eye worm) ctsf protein 0.0064 0.0209 0.0241
Giardia lamblia Cysteine protease 0.0046 0.0094 0.0276
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0218 0.1183 0.1343
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0194
Echinococcus granulosus neuropeptide s receptor 0.0493 0.2925 0.3361
Echinococcus multilocularis Calcium binding protein 0.0044 0.008 0.0074
Brugia malayi beta-lactamase family protein 0.0109 0.0495 0.0563
Echinococcus granulosus cathepsin l1 0.0057 0.0162 0.018
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0046 0.0094 0.0101
Brugia malayi EF hand family protein 0.0034 0.0018 0.0014
Schistosoma mansoni patched 1 0.0044 0.0079 0.0084
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.014 0.0155
Schistosoma mansoni cathepsin B (C01 family) 0.0046 0.0094 0.0101
Echinococcus multilocularis cysteine protease 0.0064 0.0209 0.0203
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0046 0.0094 0.0648
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0194
Entamoeba histolytica cysteine proteinase, putative 0.0064 0.0209 0.1641
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Giardia lamblia Cysteine protease 0.0046 0.0094 0.0276
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Giardia lamblia Cysteine protease 0.0046 0.0094 0.0276
Plasmodium falciparum serine repeat antigen 1 0.0046 0.0094 0.0648
Brugia malayi Cathepsin L-like precursor 0.0064 0.0209 0.0234
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0194
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0046 0.0094 0.0276
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0132 0.0416
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0098 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0055 0.0134
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.014 0.105
Brugia malayi MAP kinase sur-1 0.0052 0.0132 0.0145
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0098 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.014 0.105
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Brugia malayi RasGEF domain containing protein 0.0044 0.008 0.0086
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Schistosoma mansoni cathepsin S (C01 family) 0.0046 0.0094 0.0101
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0202 0.1081 0.1226
Loa Loa (eye worm) calpain D 0.0061 0.0186 0.0214
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0046 0.0094 0.0648
Onchocerca volvulus 0.0109 0.0495 0.2586
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0046 0.0094 0.0648
Entamoeba histolytica hypothetical protein 0.0073 0.0264 0.2108
Plasmodium falciparum serine repeat antigen 6 0.0046 0.0094 0.0648
Echinococcus multilocularis Myosin regulatory light chain 0.0044 0.008 0.0074
Entamoeba histolytica grainin 2 0.0078 0.0297 0.2393
Giardia lamblia Cathepsin L precursor 0.0046 0.0094 0.0276
Echinococcus granulosus Calcium binding protein 0.0044 0.008 0.0086
Onchocerca volvulus 0.0064 0.0209 0.1093
Plasmodium vivax unspecified product 0.0046 0.0094 0.0648
Echinococcus granulosus calpain A 0.057 0.3411 0.392
Brugia malayi TAR-binding protein 0.0066 0.0217 0.0244
Loa Loa (eye worm) EF hand family protein 0.0034 0.0018 0.0021
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0448 0.0442
Schistosoma mansoni hypothetical protein 0.0034 0.0018 0.0014
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0034 0.0018 0.0014
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0046 0.0094 0.0648
Onchocerca volvulus 0.0034 0.0018 0.0095
Schistosoma mansoni hypothetical protein 0.0042 0.0069 0.0072
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Loa Loa (eye worm) fibroinase 0.0064 0.0209 0.0241
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0209 0.0699
Giardia lamblia Cathepsin B precursor 0.0046 0.0094 0.0276
Entamoeba histolytica cysteine protease, putative 0.0046 0.0094 0.0648
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0132 0.0416
Loa Loa (eye worm) RNA binding protein 0.0066 0.0217 0.025
Echinococcus multilocularis programmed cell death protein 6 0.0044 0.008 0.0074
Entamoeba histolytica hypothetical protein 0.0073 0.0264 0.2108
Brugia malayi Cathepsin L-like precursor 0.0064 0.0209 0.0234
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.0495 0.0489
Toxoplasma gondii preprocathepsin c precursor, putative 0.0046 0.0094 0.0276
Brugia malayi Myosin regulatory light chain 1 0.0044 0.008 0.0086
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0044 0.008 0.0419
Trichomonas vaginalis centrin, putative 0.0044 0.008 0.0227
Echinococcus multilocularis geminin 0.0526 0.3136 0.3131
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0202 0.1081 0.1226
Loa Loa (eye worm) hypothetical protein 0.0394 0.2299 0.2645
Onchocerca volvulus 0.0064 0.0209 0.1093
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0046 0.0094 0.0648
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0061 0.0186 0.0194
Echinococcus granulosus calpain 7 C02 family 0.0202 0.1081 0.1238
Echinococcus granulosus calcyphosin protein 0.0044 0.008 0.0086
Plasmodium falciparum cysteine proteinase falcipain 1 0.0054 0.014 0.105
Loa Loa (eye worm) hypothetical protein 0.1403 0.8691 1
Schistosoma mansoni ef hand domain family member A2 0.0034 0.0018 0.0014
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0054 0.014 0.0155
Loa Loa (eye worm) beta-lactamase 0.0109 0.0495 0.057
Loa Loa (eye worm) hypothetical protein 0.0188 0.0993 0.1142
Loa Loa (eye worm) myosin Light Chain family member 0.0044 0.008 0.0092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Schistosoma mansoni calpain (C02 family) 0.0202 0.1081 0.1238
Loa Loa (eye worm) cysteine protease 0.0064 0.0209 0.0241
Loa Loa (eye worm) hypothetical protein 0.0334 0.1915 0.2203
Loa Loa (eye worm) hypothetical protein 0.0046 0.0094 0.0108
Entamoeba histolytica cysteine protease, putative 0.0046 0.0094 0.0648
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0098 0.0106
Echinococcus multilocularis programmed cell death protein 0.0078 0.0297 0.0291
Trypanosoma brucei protein kinase, putative 0.0052 0.0132 0.0416
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0094 0.0276
Schistosoma mansoni reticulocalbin 0.0034 0.0018 0.0014
Plasmodium falciparum serine repeat antigen 5 0.0046 0.0094 0.0648
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0186 0.0615
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0495 0.055
Echinococcus granulosus centrin 2 0.0034 0.0018 0.0014
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0132 0.0152
Trichomonas vaginalis kakapo, putative 0.0044 0.008 0.0227
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0202 0.1081 0.3888
Leishmania major cathepsin L-like protease 0.0064 0.0209 0.0699
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0098 0.0106
Entamoeba histolytica cysteine proteinase 2 0.0054 0.014 0.105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0162 0.0527
Brugia malayi calpain D 0.0061 0.0186 0.0208
Schistosoma mansoni calmodulin related calcium binding protein 0.0034 0.0018 0.0014
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0098 0.0092
Trypanosoma brucei centrin-3 0.0078 0.0297 0.1019
Brugia malayi cathepsin L precursor 0.0046 0.0094 0.0101
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Brugia malayi hypothetical protein 0.0073 0.0264 0.0297
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0495 0.1744
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0495 0.1744
Onchocerca volvulus 0.0064 0.0209 0.1093
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0495 0.055
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0046 0.0094 0.0648
Echinococcus granulosus EF hand domain containing family member A2 0.0034 0.0018 0.0014
Entamoeba histolytica calpain large subunit domain III containing protein 0.0141 0.0697 0.5824
Echinococcus granulosus EF HAND 1 calcium binding site 0.0034 0.0018 0.0014
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0217 0.0244
Entamoeba histolytica protein kinase, putative 0.0142 0.07 0.585
Echinococcus multilocularis calumenin 0.0034 0.0018 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.014 0.0447
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0064 0.0209 0.0203
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0132 0.0416
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0064 0.0209 0.1641
Loa Loa (eye worm) hypothetical protein 0.0536 0.3194 0.3675
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0186 0.0194
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0068 0.0229 0.0257
Echinococcus granulosus cathepsin b 0.1403 0.8691 1
Plasmodium vivax calpain, putative 0.0202 0.1081 0.9127
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Brugia malayi latrophilin 2 splice variant baaae 0.0146 0.0726 0.0829
Echinococcus granulosus cathepsin l1 0.0064 0.0209 0.0234
Toxoplasma gondii cathepsin B 0.0466 0.2753 1
Plasmodium falciparum serine repeat antigen 2 0.0046 0.0094 0.0648
Loa Loa (eye worm) programmed cell death protein 6 0.0034 0.0018 0.0021
Onchocerca volvulus 0.0044 0.008 0.0419
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0202 0.1081 0.3888
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0046 0.0094 0.0648
Plasmodium falciparum serine repeat antigen 3 0.0046 0.0094 0.0648
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0162 0.0166
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0194
Plasmodium falciparum serine repeat antigen 8 0.0046 0.0094 0.0648
Loa Loa (eye worm) hypothetical protein 0.004 0.0055 0.0063
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0218 0.1183 0.1355
Schistosoma mansoni reticulocalbin 0.0034 0.0018 0.0014
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0061 0.0186 0.0615
Leishmania major hypothetical protein, conserved 0.0109 0.0495 0.1744
Brugia malayi fibroinase precursor 0.0046 0.0094 0.0101
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0061 0.0186 0.0615
Echinococcus granulosus EF hand domain containing family member A2 0.0034 0.0018 0.0014
Loa Loa (eye worm) calmodulin-like protein 0.0034 0.0018 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0094 0.0276
Onchocerca volvulus Cathepsin L homolog 0.0046 0.0094 0.0489
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0046 0.0094 0.0108
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.008 0.0072
Giardia lamblia Cathepsin B precursor 0.0466 0.2753 1
Plasmodium vivax unspecified product 0.0054 0.014 0.105
Plasmodium vivax myosin A tail domain interacting protein MTIP, putative 0.0044 0.008 0.0534
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0495 0.4094
Echinococcus granulosus cathepsin L 0.0054 0.014 0.0155
Toxoplasma gondii cathepsin CPL 0.0064 0.0209 0.0699
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0061 0.0186 0.0194
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0046 0.0094 0.0648
Brugia malayi cathepsin F-like cysteine proteinase 0.0046 0.0094 0.0101
Leishmania major hypothetical protein, conserved 0.0061 0.0186 0.0615
Loa Loa (eye worm) hypothetical protein 0.0057 0.0162 0.0187
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0046 0.0094 0.0648
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0186 0.0194
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0209 0.022
Onchocerca volvulus 0.0334 0.1915 1
Trichomonas vaginalis caltractin, putative 0.0044 0.008 0.0227
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0132 0.0145
Trypanosoma brucei antigen, putative 0.0202 0.1081 0.3888
Echinococcus granulosus calmodulin 0.0034 0.0018 0.0014
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0079 0.0073
Schistosoma mansoni neuronal calcium sensor 0.0034 0.0018 0.0014
Schistosoma mansoni cathepsin C 0.0046 0.0094 0.0101
Onchocerca volvulus 0.0057 0.0162 0.0848
Schistosoma mansoni calmodulin 0.0034 0.0018 0.0014
Trichomonas vaginalis caltractin, putative 0.0044 0.008 0.0227
Brugia malayi Heterochromatin protein 1 0.0071 0.0253 0.0285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Trypanosoma cruzi cysteine proteinase, putative 0.0054 0.014 0.0141
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0194
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0074 0.0386
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0209 0.0699
Echinococcus multilocularis EF hand domain containing family member A2 0.0034 0.0018 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0064 0.0209 0.0699
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 1 % Displacement of [3H]ZM241385 from human recombinant adenosine A2A receptor expressed in CHO cell membranes at 1 uM by scintillation counting ChEMBL. 21616671
Inhibition (binding) = 1 % Displacement of [125I]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells at 1 uM by scintillation counting ChEMBL. 21616671
Inhibition (functional) = 3 % Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP levels at 1 uM ChEMBL. 21616671
Ki (binding) = 455 nM Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in CHO cell membranes by scintillation counting ChEMBL. 21616671

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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