Detailed information for compound 103044

Basic information

Technical information
  • TDR Targets ID: 103044
  • Name: 3-hydroxypropyl-dimethyl-[[4-[[7-(4-methylphe nyl)-2,3-dihydro-1-benzoxepine-4-carbonyl]ami no]phenyl]methyl]azanium iodide
  • MW: 598.515 | Formula: C30H35IN2O3
  • H donors: 2 H acceptors: 2 LogP: 5.65 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCCC[N+](Cc1ccc(cc1)NC(=O)C1=Cc2cc(ccc2OCC1)c1ccc(cc1)C)(C)C.[I-]
  • InChi: 1S/C30H34N2O3.HI/c1-22-5-9-24(10-6-22)25-11-14-29-27(19-25)20-26(15-18-35-29)30(34)31-28-12-7-23(8-13-28)21-32(2,3)16-4-17-33;/h5-14,19-20,33H,4,15-18,21H2,1-3H3;1H
  • InChiKey: FANJFZGLCWKZRI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-hydroxypropyl-dimethyl-[[4-[[7-(p-tolyl)-2,3-dihydro-1-benzoxepine-4-carbonyl]amino]phenyl]methyl]ammonium iodide
  • 3-hydroxypropyl-dimethyl-[[4-[[oxo-[7-(p-tolyl)-2,3-dihydro-1-benzoxepin-4-yl]methyl]amino]phenyl]methyl]ammonium iodide
  • 3-hydroxypropyl-dimethyl-[[4-[[7-(4-methylphenyl)-2,3-dihydro-1-benzoxepin-4-yl]carbonylamino]phenyl]methyl]azanium iodide
  • 3-hydroxypropyl-dimethyl-[4-[[7-(p-tolyl)-2,3-dihydro-1-benzoxepine-4-carbonyl]amino]benzyl]ammonium iodide
  • 3-hydroxypropyl-dimethyl-[[4-[[7-(4-methylphenyl)2,3-dihydro-1-benzoxepine-4-carbonyl]amino]phenyl]methyl]azanium iodide
  • 3-hydroxypropyl-dimethyl-[[4-[[7-(p-tolyl)2,3-dihydro-1-benzoxepine-4-carbonyl]amino]phenyl]methyl]ammonium iodide
  • 3-hydroxypropyl-dimethyl-[4-[[7-(p-tolyl)2,3-dihydro-1-benzoxepine-4-carbonyl]amino]benzyl]ammonium iodide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-C motif) receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.2055 0.2299
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.005 0.0159
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0215 0.2291 0.2557
Onchocerca volvulus 0.0096 0.0979 0.3701
Loa Loa (eye worm) hypothetical protein 0.003 0.025 0.0464
Mycobacterium ulcerans hypothetical protein 0.0024 0.0184 0.1576
Trypanosoma brucei ISWI complex protein 0.0015 0.0086 0.0476
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Trichomonas vaginalis ferritin, putative 0.0008 0.001 0.0004
Schistosoma mansoni glucose transport protein 0.0215 0.2291 0.2562
Giardia lamblia Lysyl-tRNA synthetase 0.0048 0.0447 0.6849
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0649 0.0719
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Trypanosoma brucei glucose transporter, putative 0.0067 0.0653 0.5724
Echinococcus granulosus microtubule associated protein 2 0.0816 0.8941 1
Loa Loa (eye worm) sugar transporter 0.0215 0.2291 0.4349
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0209
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.061 0.0682
Loa Loa (eye worm) hypothetical protein 0.0054 0.0518 0.0974
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0106 0.0118
Mycobacterium ulcerans hypothetical protein 0.0011 0.0035 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0653 0.2459
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0184 0.023
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0066 0.0649 0.0719
Trichomonas vaginalis sugar transport protein, putative 0.003 0.025 0.0923
Loa Loa (eye worm) hypothetical protein 0.0108 0.1115 0.211
Brugia malayi CXXC zinc finger family protein 0.0029 0.0238 0.044
Brugia malayi mbt repeat family protein 0.0048 0.0445 0.0834
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Loa Loa (eye worm) hypothetical protein 0.0048 0.0445 0.0834
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.1115 0.1241
Echinococcus multilocularis expressed protein 0.0008 0.001 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0035 0.01
Brugia malayi hypothetical protein 0.0008 0.0008 0.0003
Onchocerca volvulus 0.003 0.025 0.0923
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0105 0.0127
Loa Loa (eye worm) hypothetical protein 0.003 0.025 0.0464
Schistosoma mansoni ferritin 0.0008 0.001 0.0011
Brugia malayi beta-lactamase family protein 0.0108 0.1115 0.211
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0265 0.0296
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.025 0.0464
Schistosoma mansoni ferritin light chain 0.0008 0.001 0.0011
Schistosoma mansoni glucose transporter 0.003 0.025 0.028
Giardia lamblia Sugar-proton symporter 0.003 0.025 0.346
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0008 0.0008 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0184 0.138
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0091 0.0095
Trypanosoma brucei glucose transporter, putative 0.0067 0.0653 0.5724
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0233 0.1833
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.005 0.0367
Trypanosoma cruzi glucose transporter, putative 0.003 0.025 0.1998
Loa Loa (eye worm) G protein alpha subunit 3 0.0008 0.0008 0.0003
Brugia malayi beta-lactamase 0.0108 0.1115 0.211
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Plasmodium vivax SET domain protein, putative 0.0031 0.0265 0.0216
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0083
Brugia malayi hypothetical protein 0.0018 0.0121 0.0217
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.005 0.0049
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0064 0.0629 0.9689
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Onchocerca volvulus 0.003 0.025 0.0923
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0184 0.1576
Onchocerca volvulus 0.003 0.025 0.0923
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.025 0.1998
Loa Loa (eye worm) hypothetical protein 0.0044 0.0407 0.0763
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0116 0.0066
Plasmodium vivax proline--tRNA ligase, putative 0.0075 0.0747 0.07
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0064 0.0629 0.5603
Leishmania major hypothetical protein, conserved 0.003 0.025 0.1998
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0367 0.3231
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0012 0.005 0.0651
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0653 0.2459
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0692 0.7573 1
Onchocerca volvulus 0.0108 0.1115 0.4221
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0048 0.0447 0.1671
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0812 0.8898 0.9952
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0649 0.2443
Trypanosoma brucei glucose transporter, putative 0.0067 0.0653 0.5724
Echinococcus granulosus solute carrier family 22 0.003 0.025 0.0273
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Trypanosoma brucei protein kinase, putative 0.0056 0.0536 0.4643
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0323 0.4707
Brugia malayi Cam kinase protein 1 0.0066 0.0649 0.1223
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.005 0.0367
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0653 0.2459
Entamoeba histolytica protein kinase, putative 0.0066 0.0649 1
Trichomonas vaginalis conserved hypothetical protein 0.0215 0.2291 0.8708
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0008 0.0008 0.0003
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0649 0.0719
Brugia malayi Major Facilitator Superfamily protein 0.003 0.025 0.0464
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0589 0.0652
Plasmodium falciparum calcium-dependent protein kinase 5 0.0066 0.0649 0.0602
Brugia malayi beta-lactamase family protein 0.0108 0.1115 0.211
Treponema pallidum threonyl-tRNA synthetase 0.0012 0.005 0.256
Schistosoma mansoni ferritin 0.0008 0.001 0.0011
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0066 0.0649 0.5686
Loa Loa (eye worm) hypothetical protein 0.0016 0.0091 0.0161
Brugia malayi mbt repeat family protein 0.0048 0.0445 0.0834
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.1115 0.4221
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.005 0.0144
Echinococcus granulosus ferritin 0.0008 0.001 0.0003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0589 0.5243
Loa Loa (eye worm) hypothetical protein 0.0108 0.1115 0.211
Brugia malayi hypothetical protein 0.003 0.025 0.0464
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.005 0.0024
Loa Loa (eye worm) sugar transporter 0.003 0.025 0.0464
Onchocerca volvulus 0.003 0.025 0.0923
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0589 0.0659
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0003
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0445 0.049
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0008 0.0008 0.0009
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0066 0.0649 0.0602
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0066 0.0649 0.0932
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0008 0.0008 0.0003
Schistosoma mansoni smad1 5 8 and 0.0008 0.0007 0.0008
Schistosoma mansoni sugar transporter 0.003 0.025 0.028
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0653 0.2459
Schistosoma mansoni sugar transporter 0.003 0.025 0.028
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0323 0.0354
Trypanosoma cruzi hexose transporter 0.0067 0.0653 0.5724
Loa Loa (eye worm) hypothetical protein 0.003 0.025 0.0464
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0589 0.5132
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0536 0.0593
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0116 0.0141
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0184 0.1576
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0536 0.4643
Loa Loa (eye worm) histone methyltransferase 0.001 0.0028 0.0041
Loa Loa (eye worm) hypothetical protein 0.0483 0.5259 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0323 0.0354
Leishmania major protein kinase, putative 0.0066 0.0649 0.5686
Echinococcus granulosus lysyl tRNA synthetase 0.0048 0.0447 0.0492
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.025 0.0201
Mycobacterium leprae Probable lipase LipE 0.0108 0.1115 1
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0008 0.0009
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0064 0.0629 0.1185
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0347 0.3759 0.5646
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.005 0.0083
Plasmodium falciparum calcium-dependent protein kinase 1 0.0066 0.0649 0.0602
Plasmodium vivax CDK-related protein kinase 6, putative 0.0911 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0233 0.043
Echinococcus multilocularis solute carrier family 22 0.003 0.025 0.0273
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.025 0.0319
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0536 0.2013
Toxoplasma gondii protein kinase, putative 0.0607 0.6631 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0048 0.0447 0.3954
Plasmodium falciparum proline--tRNA ligase 0.0075 0.0747 0.07
Echinococcus granulosus solute carrier family 22 0.003 0.025 0.0273
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.005 0.0049
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0536 0.1008
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0536 0.0593
Schistosoma mansoni GTP-binding protein alpha subunit 0.0008 0.0008 0.0009
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0454 0.05
Toxoplasma gondii sugar transporter ST2 0.003 0.025 0.0327
Onchocerca volvulus 0.003 0.025 0.0923
Schistosoma mansoni hypothetical protein 0.0021 0.0145 0.0162
Plasmodium vivax hypothetical protein, conserved 0.0108 0.1115 0.107
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0008 0.0008 0.0009
Echinococcus granulosus expressed protein 0.0008 0.0008 0.0002
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0145 0.0264
Leishmania major hypothetical protein, conserved 0.0108 0.1115 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.1115 0.211
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0445 0.049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0265 0.0296
Echinococcus granulosus calcium dependent protein kinase 0.0062 0.0599 0.0663
Schistosoma mansoni protein kinase 0.0066 0.0649 0.0726
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0238 0.044
Schistosoma mansoni ferritin 0.0008 0.001 0.0011
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.025 0.0273
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Onchocerca volvulus Putative transporter 0.003 0.025 0.0923
Mycobacterium ulcerans hypothetical protein 0.0108 0.1115 1
Loa Loa (eye worm) hypothetical protein 0.003 0.025 0.0464
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0209
Echinococcus granulosus dnaJ subfamily B 0.0413 0.4489 0.5016
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0447 0.3954
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0008 0.0008 0.0003
Echinococcus granulosus neuropeptide s receptor 0.0467 0.5088 0.5687
Loa Loa (eye worm) hypothetical protein 0.0096 0.0979 0.185
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.1115 0.1241
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0091 0.0095
Brugia malayi Sugar transporter family protein 0.003 0.025 0.0464
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0008 0.0008 0.0009
Onchocerca volvulus 0.0031 0.0265 0.0977
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Schistosoma mansoni protein kinase 0.0066 0.0649 0.0726
Loa Loa (eye worm) hypothetical protein 0.003 0.025 0.0464
Loa Loa (eye worm) hypothetical protein 0.0048 0.0447 0.0838
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0003
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0106 0.0111
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.1115 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0469 0.088
Echinococcus granulosus survival motor neuron protein 1 0.0483 0.5259 0.5879
Brugia malayi MH2 domain containing protein 0.0119 0.1239 0.2346
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0315 0.0345
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0106 0.0111
Echinococcus multilocularis GPCR, family 2 0.0016 0.0091 0.0095
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0653 0.5724
Onchocerca volvulus 0.003 0.025 0.0923
Plasmodium falciparum lysine--tRNA ligase 0.0048 0.0447 0.0398
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.1006 0.1903
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.005 0.0144
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0536 0.2013
Trypanosoma brucei glucose transporter, putative 0.0067 0.0653 0.5724
Echinococcus multilocularis survival motor neuron protein 1 0.0483 0.5259 0.5879
Brugia malayi major facilitator superfamily protein 0.003 0.025 0.0464
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.1115 0.1462
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0116 0.1666
Trypanosoma brucei sugar transporter, putative 0.003 0.025 0.1998
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.1999 0.2229
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0106 0.0118
Trypanosoma cruzi sugar transporter, putative 0.003 0.025 0.1998
Loa Loa (eye worm) hypothetical protein 0.003 0.025 0.0464
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0518 0.0572
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0518 0.0572
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.025 0.0273
Brugia malayi hypothetical protein 0.0483 0.5259 1
Onchocerca volvulus 0.003 0.025 0.0923
Schistosoma mansoni hypothetical protein 0.0016 0.0091 0.0102
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0454 0.0507
Schistosoma mansoni smad 0.0008 0.0007 0.0008
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0649 0.0719
Trichomonas vaginalis conserved hypothetical protein 0.003 0.025 0.0923
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0184 0.2737
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0536 0.4643
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0048 0.0447 0.3813
Schistosoma mansoni zinc finger protein 0.0015 0.0086 0.0096
Brugia malayi hypothetical protein 0.003 0.025 0.0464
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0215 0.2291 0.2557
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0265 0.0289
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0323 0.2665
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0323 0.1198
Schistosoma mansoni glucose transport protein 0.0215 0.2291 0.2562
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1239 0.2346
Schistosoma mansoni hypothetical protein 0.0695 0.7607 0.8507
Echinococcus multilocularis neuropeptide receptor A26 0.0467 0.5088 0.5687
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0629 0.0703
Plasmodium vivax sugar transporter, putative 0.003 0.025 0.0201
Schistosoma mansoni hypothetical protein 0.0034 0.0294 0.0329
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0315 0.0345
Loa Loa (eye worm) hypothetical protein 0.003 0.025 0.0464
Plasmodium falciparum hexose transporter 0.0215 0.2291 0.2252
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0012 0.005 0.1686
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.025 0.2179
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0012 0.005 0.0651
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0184 0.1576
Echinococcus multilocularis zinc finger protein 0.0021 0.0152 0.0162
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.025 0.0319
Loa Loa (eye worm) hypothetical protein 0.0024 0.0184 0.0337
Onchocerca volvulus 0.0108 0.1115 0.4221
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0381 0.1422
Leishmania major glucose transporter, lmgt3 0.0067 0.0653 0.5724
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0564 0.0802
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0653 0.2459
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.025 0.0273
Brugia malayi major facilitator superfamily protein 0.003 0.025 0.0464
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0066 0.0649 0.0602
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.1115 0.4221
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0536 0.2013
Loa Loa (eye worm) hypothetical protein 0.0024 0.0184 0.0337
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0105 0.0127
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0091 0.0161
Trypanosoma cruzi ISWI complex protein 0.0015 0.0086 0.0476
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.1115 0.1462
Trypanosoma brucei glucose transporter 2A 0.0067 0.0653 0.5724
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0184 0.1576
Loa Loa (eye worm) hypothetical protein 0.003 0.025 0.0464
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.1115 1
Mycobacterium leprae conserved hypothetical protein 0.0011 0.0035 0.0227
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.025 0.2179
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.005 0.0049
Schistosoma mansoni hypothetical protein 0.0015 0.0086 0.0096
Loa Loa (eye worm) hypothetical protein 0.0037 0.0323 0.0601
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Mycobacterium ulcerans sugar transporter 0.003 0.025 0.2179
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0096 0.0979 0.1095
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0747 0.6594
Trichomonas vaginalis conserved hypothetical protein 0.003 0.025 0.0923
Loa Loa (eye worm) hypothetical protein 0.0071 0.07 0.132
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.1115 0.1462
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.005 0.0144
Echinococcus multilocularis ferritin 0.0008 0.001 0.0003
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0185 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0035 0.01
Loa Loa (eye worm) hypothetical protein 0.0041 0.0368 0.0687
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0064 0.0629 0.0697
Echinococcus multilocularis lysyl tRNA synthetase 0.0048 0.0447 0.0492
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Loa Loa (eye worm) hypothetical protein 0.003 0.025 0.0464
Schistosoma mansoni cpg binding protein 0.0029 0.0238 0.0266
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0518 0.0572
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0747 0.6594
Loa Loa (eye worm) hypothetical protein 0.0052 0.0495 0.093
Loa Loa (eye worm) hypothetical protein 0.0064 0.0629 0.1185
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0653 0.5724
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0075 0.0747 0.108
Brugia malayi Major Facilitator Superfamily protein 0.003 0.025 0.0464
Schistosoma mansoni hypothetical protein 0.0016 0.0091 0.0102
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0215 0.2291 0.2557
Mycobacterium tuberculosis Conserved protein 0.0108 0.1115 0.1462
Brugia malayi Bromodomain containing protein 0.0038 0.0341 0.0636
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.2055 0.2293
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0066 0.0649 0.1223
Loa Loa (eye worm) hypothetical protein 0.0096 0.0979 0.185
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0064 0.0629 0.0697
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0091 0.0161
Echinococcus multilocularis solute carrier family 22 0.003 0.025 0.0273
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.005 0.0144
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.025 0.028
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0233 0.1833
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0445 0.049
Schistosoma mansoni bromodomain containing protein 0.0065 0.0636 0.0711
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.1999 0.2229
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0008 0.0008 0.0009
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0445 0.0498
Plasmodium vivax lysine--tRNA ligase, putative 0.0048 0.0447 0.0398
Trypanosoma cruzi ISWI complex protein 0.0015 0.0086 0.0476
Brugia malayi PHD-finger family protein 0.0027 0.0211 0.0389
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0596 0.066
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0454 0.05
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0233 0.1833
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0215 0.2291 0.2557
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0747 0.6594
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0445 0.1665
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0184 0.138
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0747 0.6594
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0294 0.0547
Mycobacterium tuberculosis Conserved hypothetical protein 0.0011 0.0035 0.0033
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.025 0.1998
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.1115 0.1462
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0447 0.05
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0209
Echinococcus multilocularis calcium dependent protein kinase 0.0062 0.0599 0.0663
Schistosoma mansoni zinc finger protein 0.0021 0.0152 0.017
Echinococcus granulosus cpg binding protein 0.0033 0.0277 0.0303
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.1115 0.1462
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0215 0.2291 0.2557
Leishmania major hypothetical protein, conserved 0.0015 0.0086 0.0476
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0028 0.0024
Schistosoma mansoni cpg binding protein 0.0033 0.0277 0.031
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0233 0.0183
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0008 0.0003
Trichomonas vaginalis glucose transporter, putative 0.003 0.025 0.0923
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0008 0.0008 0.0009
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0589 0.0652
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0008 0.0003
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0445 0.049
Echinococcus granulosus neuropeptide receptor A26 0.0467 0.5088 0.5687
Trypanosoma brucei glucose transporter, putative 0.0067 0.0653 0.5724
Schistosoma mansoni microtubule-associated protein tau 0.0816 0.8941 1
Brugia malayi G-protein alpha subunit 0.0008 0.0008 0.0003
Echinococcus granulosus solute carrier family 22 0.003 0.025 0.0273
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.0168 0.1435
Schistosoma mansoni hypothetical protein 0.0016 0.0091 0.0102
Schistosoma mansoni glucose transport protein 0.0215 0.2291 0.2562
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0066 0.0649 0.0932
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0536 0.0593
Trichomonas vaginalis conserved hypothetical protein 0.003 0.025 0.0923
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0066 0.0649 0.1223
Leishmania major lysyl-tRNA synthetase, putative 0.0048 0.0447 0.3813
Onchocerca volvulus 0.0029 0.0238 0.0874
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0008 0.0008 0.0003
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0091 0.0095
Schistosoma mansoni ferritin 0.0008 0.001 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0184 0.1576
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0009 0.001
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0008 0.0009
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0116 0.0965
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0323 0.1198
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0003
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.4489 0.5016
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0653 0.5724
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0589 0.5243
Onchocerca volvulus 0.003 0.025 0.0923
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0008 0.0008 0.0002
Leishmania major glucose transporter, lmgt2 0.0067 0.0653 0.5724
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Brugia malayi Trypsin family protein 0.0096 0.0979 0.185
Onchocerca volvulus 0.003 0.025 0.0923
Schistosoma mansoni GTP-binding protein alpha subunit 0.0008 0.0008 0.0009
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.005 0.0144
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.005 0.0054
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0347 0.3759 0.3727
Leishmania major glucose transporter/membrane transporter D2, putative 0.0067 0.0653 0.5724
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0184 0.023
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0323 0.4905
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0105 0.0127
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0649 0.0719
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0008 0.0008 0.0002
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.1115 0.211
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.2576 0.4891
Entamoeba histolytica hypothetical protein 0.0048 0.0447 0.6841
Giardia lamblia Hexose transporter 0.003 0.025 0.346
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Onchocerca volvulus 0.003 0.025 0.0923
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0007 0.0008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.1115 0.1247
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0066 0.0649 0.0932
Trichomonas vaginalis conserved hypothetical protein 0.003 0.025 0.0923
Echinococcus granulosus expressed protein 0.0008 0.001 0.0003
Chlamydia trachomatis lysine--tRNA ligase 0.0048 0.0447 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0209
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.2055 0.2299
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0215 0.2291 0.2557
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0447 0.3954
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0008 0.0008 0.0002
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0066 0.0649 0.1223
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0112 0.0201
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.025 0.0464
Chlamydia trachomatis proline--tRNA ligase 0.0023 0.0168 0.2978
Toxoplasma gondii sugar transporter ST3 0.003 0.025 0.0327
Onchocerca volvulus 0.009 0.0909 0.3437
Brugia malayi Major Facilitator Superfamily protein 0.003 0.025 0.0464
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0008 0.0008 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.1115 0.4221
Mycobacterium tuberculosis Conserved protein 0.0108 0.1115 0.1462
Toxoplasma gondii lysine-tRNA ligase 0.0048 0.0447 0.0625
Echinococcus multilocularis solute carrier family 22 0.003 0.025 0.0273
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0008 0.0008 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.025 0.0464
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0048 0.0079
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.1115 0.4221
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.1115 1
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.005 0.0083
Schistosoma mansoni apoferritin-2 0.0008 0.001 0.0011
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0184 0.2737
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0008 0.0008 0.0003
Trypanosoma brucei glucose transporter, putative 0.0067 0.0653 0.5724
Trichomonas vaginalis set domain proteins, putative 0.0245 0.263 1
Entamoeba histolytica protein kinase, putative 0.0066 0.0649 1
Trichomonas vaginalis esterase, putative 0.0108 0.1115 0.4221
Schistosoma mansoni hypothetical protein 0.029 0.3128 0.3499
Brugia malayi glycyl-tRNA synthetase 0.0012 0.005 0.0083
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0048 0.0447 0.3813
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0536 0.4643
Schistosoma mansoni sugar transporter 0.003 0.025 0.028
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.1115 0.4221
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.0168 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0596 0.066
Echinococcus granulosus geminin 0.0695 0.7607 0.8506
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.025 0.0327
Onchocerca volvulus 0.003 0.025 0.0923
Loa Loa (eye worm) hypothetical protein 0.0064 0.0629 0.1185
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0008 0.0009
Leishmania major glucose transporter, lmgt1 0.0067 0.0653 0.5724
Onchocerca volvulus 0.003 0.025 0.0923
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0265 0.0349
Trypanosoma cruzi hexose transporter, putative 0.003 0.025 0.1998
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0209
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0323 0.0361
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0536 0.4643
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.2055 0.2293
Onchocerca volvulus 0.003 0.025 0.0923
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.025 1
Schistosoma mansoni hypothetical protein 0.0013 0.0058 0.0065
Loa Loa (eye worm) beta-lactamase 0.0108 0.1115 0.211
Onchocerca volvulus 0.0108 0.1115 0.4221
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0028 0.0024
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0323 0.0601
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0367 0.0472
Plasmodium falciparum calcium-dependent protein kinase 4 0.0066 0.0649 0.0602
Mycobacterium ulcerans integral membrane transport protein 0.003 0.025 0.2179
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0193 0.2055 0.39
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Schistosoma mansoni Smad4 0.0008 0.0007 0.0008
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0064 0.0629 0.2367
Onchocerca volvulus 0.0245 0.263 1
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0589 0.0841
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0008 0.0008 0.0002
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0536 0.076
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0209 0.0385
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0091 0.0095
Mycobacterium tuberculosis Conserved protein 0.0108 0.1115 0.1462
Leishmania major hypothetical protein, conserved 0.0029 0.0233 0.1833
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Brugia malayi hypothetical protein 0.003 0.025 0.0464
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0008 0.0008 0.0003
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0058 0.0058
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0009 0.0002
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0064 0.0629 0.1185
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0445 0.0498
Plasmodium falciparum protein kinase 7 0.0607 0.6631 0.6614
Onchocerca volvulus 0.003 0.025 0.0923
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0008 0.0008 0.0002
Mycobacterium ulcerans lipase LipD 0.0108 0.1115 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0008 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.1115 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0058 0.0058
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0008 0.0008 0.0002
Echinococcus multilocularis General substrate transporter 0.0184 0.1957 0.2183
Brugia malayi follicle stimulating hormone receptor 0.024 0.2576 0.4891
Toxoplasma gondii sugar transporter ST1 0.003 0.025 0.0327
Schistosoma mansoni survival motor neuron protein 0.0098 0.1006 0.1126
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.005 0.0024
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0323 0.1198
Brugia malayi Sugar transporter family protein 0.0215 0.2291 0.4349
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0536 0.06
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Loa Loa (eye worm) hypothetical protein 0.003 0.025 0.0464
Trypanosoma brucei glucose transporter 1E 0.0067 0.0653 0.5724
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0323 0.2665
Toxoplasma gondii ABC1 family protein 0.0108 0.1115 0.1638
Schistosoma mansoni hypothetical protein 0.0413 0.4489 0.502
Brugia malayi Pre-SET motif family protein 0.0031 0.0265 0.0491
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.005 0.0049
Mycobacterium leprae conserved hypothetical protein 0.0108 0.1115 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0323 0.0354
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.005 0.0367
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0008 0.0008 0.0003
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0445 0.0498
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0323 0.0354
Trypanosoma brucei glucose transporter, putative 0.0067 0.0653 0.5724
Brugia malayi Pre-SET motif family protein 0.0215 0.2301 0.4369
Onchocerca volvulus 0.0098 0.1006 0.3807
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0323 0.0361
Loa Loa (eye worm) hypothetical protein 0.003 0.025 0.0464
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0536 0.4643
Onchocerca volvulus 0.0048 0.0445 0.1665
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0008 0.0003
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0649 0.0719
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0536 0.4643
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0008 0.0008 0.0009
Schistosoma mansoni smad1 5 8 and 0.0008 0.0007 0.0008
Echinococcus multilocularis expressed protein 0.0008 0.0008 0.0002
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0185 0.0206
Loa Loa (eye worm) hypothetical protein 0.003 0.025 0.0464
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0009 0.0002
Echinococcus multilocularis geminin 0.0695 0.7607 0.8506
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0003
Schistosoma mansoni hypothetical protein 0.0215 0.2291 0.2562
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0184 0.0337
Loa Loa (eye worm) hypothetical protein 0.0108 0.1115 0.211
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0091 0.0161
Onchocerca volvulus 0.003 0.025 0.0923
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.025 0.0273
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0589 0.5243
Onchocerca volvulus 0.0024 0.0184 0.0669
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.1115 0.1247
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0184 0.1576
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0653 0.5724
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0536 0.4643
Brugia malayi Sugar transporter family protein 0.003 0.025 0.0464
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0184 0.1576
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.025 0.0923
Schistosoma mansoni hypothetical protein 0.0016 0.0091 0.0102
Loa Loa (eye worm) hypothetical protein 0.0024 0.0184 0.0337
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0747 0.6594
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.1115 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0066 0.0649 0.0602
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0536 0.2013
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0653 0.5724
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0009 0.0002
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0008 0.0008 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0035 0.01
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0233 0.03
Mycobacterium ulcerans beta-lactamase 0.0108 0.1115 1
Echinococcus granulosus General substrate transporter 0.0184 0.1957 0.2183
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0323 0.0354
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0105 0.0127
Brugia malayi hypothetical protein 0.0029 0.0233 0.043
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0008 0.0008 0.0003
Trypanosoma brucei glucose transporter, putative 0.0067 0.0653 0.5724
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0454 0.0507
Loa Loa (eye worm) hypothetical protein 0.003 0.025 0.0464
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0066 0.0649 0.0602
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0469 0.088
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0215 0.2291 0.2557
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0629 0.0703
Echinococcus multilocularis cpg binding protein 0.0033 0.0277 0.0303
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.2055 0.2299
Trichomonas vaginalis conserved hypothetical protein 0.003 0.025 0.0923
Plasmodium vivax hexose transporter 0.0215 0.2291 0.2252
Schistosoma mansoni hypothetical protein 0.0695 0.7607 0.8507
Echinococcus multilocularis microtubule associated protein 2 0.0816 0.8941 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.2301 0.4369
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0323 0.2665
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0653 0.2459
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0469 0.088
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1239 0.2346
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0649 0.0726
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0518 0.0974
Loa Loa (eye worm) hypothetical protein 0.0066 0.0649 0.1223
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0184 0.1576
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.005 0.0083
Echinococcus granulosus zinc finger protein 0.0021 0.0152 0.0162
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0589 0.0766
Loa Loa (eye worm) hypothetical protein 0.0049 0.0454 0.0851
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.1115 0.1462
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0184 0.1576
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0233 0.0183
Giardia lamblia Prolyl-tRNA synthetase 0.0064 0.0629 1
Echinococcus multilocularis neuropeptide s receptor 0.0467 0.5088 0.5687
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0233 0.0183
Loa Loa (eye worm) hypothetical protein 0.0108 0.1115 0.211
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.005 0.0083
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0653 0.5724
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0041 0.0367 0.0472
Echinococcus multilocularis solute carrier family 22 0.003 0.025 0.0273
Schistosoma mansoni ferritin light chain 0.0008 0.001 0.0011
Onchocerca volvulus 0.003 0.025 0.0923
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0184 0.0337
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0649 0.0719
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0184 0.138
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0447 0.05
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.1115 0.1462
Echinococcus granulosus solute carrier family 22 0.003 0.025 0.0273
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0008 0.0008 0.0003
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0116 0.0066
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.005 0.0056
Loa Loa (eye worm) hypothetical protein 0.0038 0.0342 0.0638
Loa Loa (eye worm) hypothetical protein 0.003 0.025 0.0464
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0008 0.0008 0.0009
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0323 0.2665
Schistosoma mansoni smad1 5 8 and 0.0008 0.0007 0.0008
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0589 0.0659
Loa Loa (eye worm) MBCTL1 0.0054 0.0518 0.0974
Plasmodium falciparum calcium-dependent protein kinase 3 0.0066 0.0649 0.0602
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.2055 0.2293
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0245 0.0267
Brugia malayi MAP kinase sur-1 0.0056 0.0536 0.1008
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0185 0.0199
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0008 0.0008 0.0002
Brugia malayi lysyl-tRNA synthetase 0.0048 0.0447 0.0838
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0445 0.0834
Schistosoma mansoni protein kinase 0.0066 0.0649 0.0726
Schistosoma mansoni sugar transporter 0.003 0.025 0.028
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0009 0.0002
Echinococcus granulosus GPCR family 2 0.0016 0.0091 0.0095
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0184 0.2737
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0518 0.0579
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.2055 0.2293
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.1115 0.211
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0536 0.0593
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0653 0.2459
Schistosoma mansoni cpg binding protein 0.0033 0.0277 0.031
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0649 0.0719
Loa Loa (eye worm) hypothetical protein 0.005 0.0469 0.088
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Schistosoma mansoni apoferritin-2 0.0008 0.001 0.0011
Plasmodium falciparum mitogen-activated protein kinase 2 0.0347 0.3759 0.3727
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0193 0.2055 0.39
Toxoplasma gondii facilitative glucose transporter GT1 0.0215 0.2291 0.3421
Plasmodium vivax calcium-dependent protein kinase, putative 0.0066 0.0649 0.0602
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0319 0.2633
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0518 0.0572
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0536 0.8397
Schistosoma mansoni hypothetical protein 0.0098 0.1006 0.1126
Loa Loa (eye worm) hypothetical protein 0.0108 0.1115 0.211
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0184 0.0337
Brugia malayi Bromodomain containing protein 0.0077 0.0766 0.1445
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0323 0.0354
Trichomonas vaginalis sugar transporter, putative 0.003 0.025 0.0923
Loa Loa (eye worm) hypothetical protein 0.0034 0.0294 0.0547
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0096 0.0979 0.1095
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0215 0.2291 0.2557
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0012 0.005 0.1686

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.0068 uM Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES ChEMBL. 10821717
IC50 (binding) = 0.0068 uM Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES ChEMBL. 10821717

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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