Detailed information for compound 1051097

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 274.358 | Formula: C16H22N2O2
  • H donors: 0 H acceptors: 1 LogP: 3.09 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(Cc1coc(n1)c1ccc(cc1)OC)C
  • InChi: 1S/C16H22N2O2/c1-4-5-10-18(2)11-14-12-20-16(17-14)13-6-8-15(19-3)9-7-13/h6-9,12H,4-5,10-11H2,1-3H3
  • InChiKey: WZQWSCJPQQSTJM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0358
Schistosoma mansoni hypothetical protein 0.0024 0.004 0.0093
Brugia malayi Cathepsin L-like precursor 0.0016 0.0008 0.0014
Toxoplasma gondii aldehyde dehydrogenase 0.0251 0.1016 1
Entamoeba histolytica hypothetical protein 0.0039 0.0103 0.1196
Entamoeba histolytica cysteine protease, putative 0.0016 0.0008 0.0091
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0103 0.0097
Loa Loa (eye worm) hypothetical protein 0.0037 0.0099 0.0342
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0067
Loa Loa (eye worm) hypothetical protein 0.0044 0.0125 0.0432
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0103 0.0358
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0058 0.0188 0.2178
Onchocerca volvulus 0.0016 0.0008 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0188 0.0575
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0205 0.2365
Toxoplasma gondii microneme protein MIC17A 0.0015 0.0004 0.004
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0067
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0092 0.0277
Onchocerca volvulus 0.0051 0.0159 0.0489
Plasmodium vivax SET domain protein, putative 0.0095 0.0348 1
Brugia malayi hypothetical protein 0.0019 0.0019 0.0055
Loa Loa (eye worm) hypothetical protein 0.0051 0.0159 0.055
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0014
Leishmania major hypothetical protein, conserved 0.0026 0.0051 0.0437
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0021 0.0026 0.002
Echinococcus multilocularis RUN 0.002 0.0022 0.0016
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0468 0.1945 0.6738
Brugia malayi tailless protein 0.0017 0.0011 0.0023
Onchocerca volvulus 0.0044 0.0125 0.0381
Onchocerca volvulus Poor gastrulation protein homolog 0.0017 0.0009 0.0017
Entamoeba histolytica elongation factor-2 kinase, putative 0.0044 0.0125 0.1442
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0008 0.0005
Leishmania major cathepsin L-like protease 0.0062 0.0205 0.1963
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0092 0.0086
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0042 0.103
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.006 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0092 0.0317
Loa Loa (eye worm) glutamate receptor 0.004 0.0111 0.0386
Brugia malayi hypothetical protein 0.0017 0.0011 0.0023
Plasmodium falciparum thioredoxin reductase 0.0046 0.0136 0.71
Brugia malayi hypothetical protein 0.0039 0.0103 0.0358
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0099 0.0341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0078
Echinococcus granulosus expressed protein 0.0751 0.3163 0.3158
Brugia malayi nuclear receptor RXR 0.0017 0.0011 0.0023
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0019 0.0018 0.0043
Brugia malayi Cytochrome P450 family protein 0.0077 0.0269 0.0956
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0103 0.0097
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0103 0.0358
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0092 0.0086
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0008 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0092 0.0317
Brugia malayi Kringle domain containing protein 0.0024 0.004 0.013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0092 0.0086
Toxoplasma gondii subtilisin SUB12 0.0015 0.0004 0.004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0008 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0205 0.2309
Schistosoma mansoni polycystin 1-related 0.002 0.0022 0.0052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0037
Brugia malayi von Willebrand factor type A domain containing protein 0.0044 0.0125 0.0435
Mycobacterium ulcerans hydrolase 0.0019 0.0018 0.0112
Loa Loa (eye worm) hypothetical protein 0.0044 0.0125 0.0432
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0136 0.0129
Brugia malayi hypothetical protein 0.0039 0.0103 0.0358
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Schistosoma mansoni 6-phosphofructokinase 0.0216 0.0865 0.1999
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0099 0.0228
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0092 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Loa Loa (eye worm) 6-phosphofructokinase 0.0216 0.0865 0.2996
Loa Loa (eye worm) hypothetical protein 0.0044 0.0125 0.0432
Leishmania major cathepsin L-like protease 0.0062 0.0205 0.1963
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0008 0.0005
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0039 0.0386
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0205 0.2309
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0251 0.1016 0.101
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0092 0.0086
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0103 0.0097
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0092 0.0213
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0021 0.0026 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0205 0.2309
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0092 0.0086
Brugia malayi phosphofructokinase 0.0216 0.0865 0.3101
Onchocerca volvulus 0.0016 0.0008 0.0012
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0008 0.0018
Schistosoma mansoni hypothetical protein 0.0409 0.1693 0.3912
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0044 0.0125 0.0118
Treponema pallidum hypothetical protein 0.0044 0.0125 0.0271
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0004 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0037
Brugia malayi CXXC zinc finger family protein 0.0029 0.0061 0.0205
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0185 0.0179
Leishmania major cathepsin L-like protease 0.0016 0.0008 0.0015
Plasmodium vivax thrombospondin-related anonymous protein 0.0044 0.0125 0.3465
Toxoplasma gondii microneme protein MIC17C 0.0015 0.0004 0.004
Schistosoma mansoni hypothetical protein 0.0169 0.0665 0.1537
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0017 0.0009 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0092 0.0086
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0081 0.0278
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0103 0.0358
Onchocerca volvulus 0.0044 0.0125 0.0381
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0092 0.0277
Schistosoma mansoni lipoxygenase 0.002 0.0022 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0092 0.0317
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0185 0.9808
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0092 0.0213
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0188 0.5328
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0103 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0092 0.0317
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0044 0.0125 0.6504
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0008 0.0018
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0175 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0092 0.0317
Loa Loa (eye worm) hypothetical protein 0.0044 0.0125 0.0432
Echinococcus multilocularis bloom syndrome protein 0.0041 0.0112 0.0106
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0022 0.0471
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0011 0.0004
Toxoplasma gondii PAN/Apple domain-containing protein 0.0015 0.0004 0.004
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0103 0.0239
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0004 0.004
Toxoplasma gondii microneme protein MIC4 0.0015 0.0004 0.004
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0207
Echinococcus granulosus survival motor neuron protein 1 0.024 0.0966 0.096
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0092 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0103 0.0307
Schistosoma mansoni glutamate receptor NMDA 0.0021 0.0026 0.0061
Onchocerca volvulus 0.0044 0.0125 0.0381
Onchocerca volvulus 0.0044 0.0125 0.0381
Trichomonas vaginalis DNA helicase recq1, putative 0.0041 0.0112 0.0334
Echinococcus granulosus bloom syndrome protein 0.0041 0.0112 0.0106
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0004 0.004
Loa Loa (eye worm) hypothetical protein 0.004 0.0111 0.0384
Echinococcus granulosus metabotropic glutamate receptor 5 0.013 0.0497 0.049
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0081 0.0281
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0099 0.0092
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0092 0.0213
Brugia malayi nuclear hormone receptor 0.0017 0.0011 0.0023
Loa Loa (eye worm) intermediate filament protein 0.0083 0.0296 0.1026
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0136 0.3783
Echinococcus granulosus glutamate receptor 2 0.0021 0.0026 0.002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.1016 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0095 0.0348 0.0342
Loa Loa (eye worm) cysteine protease 0.0016 0.0008 0.0027
Onchocerca volvulus 0.0083 0.0296 0.0922
Brugia malayi hypothetical protein 0.024 0.0966 0.3465
Schistosoma mansoni hypothetical protein 0.0257 0.1041 0.2405
Onchocerca volvulus 0.0083 0.0296 0.0922
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0099 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0008 0.0005
Trichomonas vaginalis rotamase, putative 0.0033 0.0078 0.0226
Loa Loa (eye worm) hypothetical protein 0.0044 0.0125 0.0432
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0037
Schistosoma mansoni 6-phosphofructokinase 0.0216 0.0865 0.1999
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0011 0.0023
Echinococcus multilocularis tumor protein p63 0.0352 0.1448 0.1443
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0011 0.0024
Brugia malayi Cathepsin L-like precursor 0.0016 0.0008 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0008 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0205 0.2309
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0092 0.0213
Echinococcus granulosus slit 2 protein 0.0024 0.0042 0.0035
Brugia malayi von Willebrand factor type A domain containing protein 0.0044 0.0125 0.0435
Onchocerca volvulus 0.002 0.0022 0.0058
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0188 0.5328
Giardia lamblia Hypothetical protein 0.0019 0.0018 0.062
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0103 0.0097
Onchocerca volvulus 0.0016 0.0008 0.0012
Brugia malayi nuclear hormone receptor 0.0036 0.0092 0.0317
Brugia malayi Intermediate filament tail domain containing protein 0.0083 0.0296 0.1052
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0019 0.0018 0.0036
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0006 0.0074
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0011 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0092 0.0317
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0004 0.0014
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0389 0.3788
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0181 0.2098
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0389 0.3788
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0092 0.0317
Mycobacterium ulcerans arylsulfatase AtsB 0.0019 0.0018 0.0112
Brugia malayi nuclear receptor NHR-67 0.0017 0.0011 0.0023
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0103 0.0239
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0011 0.0004
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0019 0.0045
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0008 0.0012
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0103 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0099 0.0291
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0099 0.0092
Mycobacterium tuberculosis Probable sulfatase 0.0019 0.0018 0.0112
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0006 0.0063
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0099 0.0914
Treponema pallidum NADH oxidase 0.0016 0.0006 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Loa Loa (eye worm) hypothetical protein 0.0039 0.0104 0.0361
Brugia malayi hypothetical protein 0.002 0.0022 0.0066
Entamoeba histolytica hypothetical protein, conserved 0.0044 0.0125 0.1442
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0159 0.0367
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0092 0.0319
Entamoeba histolytica hypothetical protein 0.0039 0.0103 0.1196
Schistosoma mansoni intermediate filament proteins 0.0083 0.0296 0.0685
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0092 0.0319
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0044 0.0125 0.0432
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0058 0.0188 0.041
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0021 0.0026 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0103 0.0307
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0103 0.0097
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0022 0.0016
Loa Loa (eye worm) doublecortin family protein 0.002 0.0022 0.0078
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0185 0.1768
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0058 0.0188 0.0575
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0037
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0006 0.0074
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0185 0.1768
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0011 0.0004
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0078 0.09
Schistosoma mansoni thyroid hormone receptor 0.0293 0.1195 0.2761
Brugia malayi steroid hormone receptor 0.0036 0.0092 0.0317
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.006 0.0201
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0111 0.0104
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0214 0.0495
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0044 0.0125 0.0432
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0092 0.0086
Loa Loa (eye worm) hypothetical protein 0.0039 0.0104 0.0361
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0145
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0439 0.4286
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0008 0.0001
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0251 0.1016 0.101
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0037
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.0125 0.0435
Brugia malayi Pre-SET motif family protein 0.0095 0.0348 0.1238
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0027
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0014
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0185 0.0564
Mycobacterium ulcerans sulfatase 0.0019 0.0018 0.0112
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0358
Mycobacterium ulcerans arylsulfatase AtsD 0.0019 0.0018 0.0112
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0071 0.0636
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0103 0.0239
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.006 0.0588
Giardia lamblia Hypothetical protein 0.0019 0.0018 0.062
Brugia malayi metabotropic glutamate receptor type 2 0.0054 0.0169 0.0593
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0067
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0037
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.003 0.0067 0.0231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0205 0.2309
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Brugia malayi von Willebrand factor type A domain containing protein 0.0044 0.0125 0.0435
Onchocerca volvulus 0.0044 0.0125 0.0381
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.006 0.0053
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0044 0.0125 0.0432
Echinococcus granulosus lamin dm0 0.0083 0.0296 0.029
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0095 0.0348 0.3424
Onchocerca volvulus 0.0016 0.0008 0.0012
Schistosoma mansoni loxhd1 0.002 0.0022 0.0052
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.0042 0.0097
Leishmania major trypanothione reductase 0.0046 0.0136 0.128
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0092 0.0086
Onchocerca volvulus 0.0016 0.0008 0.0012
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0019 0.0013
Echinococcus granulosus lamin 0.0083 0.0296 0.029
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0188 1
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0099 0.0092
Loa Loa (eye worm) TK/ROR protein kinase 0.0024 0.004 0.0139
Echinococcus granulosus intermediate filament protein 0.0083 0.0296 0.029
Toxoplasma gondii 6-phosphofructokinase 0.0058 0.0188 0.1854
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0136 0.0129
Echinococcus granulosus RUN 0.002 0.0022 0.0016
Echinococcus multilocularis leukotriene A 4 hydrolase 0.025 0.1011 0.1006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0092 0.0317
Entamoeba histolytica hypothetical protein 0.0037 0.0099 0.1141
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0099 0.1141
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.006 0.0201
Brugia malayi follicle stimulating hormone receptor 0.0468 0.1945 0.6993
Toxoplasma gondii hypothetical protein 0.0015 0.0004 0.004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0092 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0103 0.0307
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0022 0.0016
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0185 0.0179
Toxoplasma gondii phosphofructokinase PFKII 0.0058 0.0188 0.1854
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0099 0.0092
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0099 0.1075
Schistosoma mansoni hypothetical protein 0.0017 0.0009 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0008 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Brugia malayi Cathepsin L-like precursor 0.0016 0.0008 0.0014
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.0042 0.0136
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.006 0.2932
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0175 0.0168
Schistosoma mansoni coup transcription factor 0.0036 0.0092 0.0213
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0188 1
Mycobacterium tuberculosis Probable reductase 0.0105 0.0389 0.3788
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0185 0.0564
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0092 0.0086
Echinococcus granulosus expressed protein 0.0033 0.0081 0.0075
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0185 0.2137
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0103 0.0239
Echinococcus multilocularis cysteine protease 0.0016 0.0008 0.0001
Loa Loa (eye worm) hypothetical protein 0.0431 0.179 0.6199
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0389 0.3788
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0006 0.0074
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0148 0.0517
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0103 0.0097
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0044 0.0125 0.3465
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Schistosoma mansoni hypothetical protein 0.0044 0.0125 0.0288
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0011 0.0021
Treponema pallidum 76K protein 0.0044 0.0125 0.0271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0205 0.2309
Entamoeba histolytica phosphofructokinase, putative 0.0216 0.0865 1
Schistosoma mansoni rotamase 0.0033 0.0081 0.0188
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0071 0.0748
Entamoeba histolytica hypothetical protein 0.0044 0.0125 0.1442
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0078 0.09
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0081 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0008 0.0005
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0008 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0092 0.0317
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0022 0.0016
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0017 0.0009 0.0019
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0188 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0145
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0008 0.0091
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0051 0.2426
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0216 0.0865 0.8504
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0004 0.0014
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0188 0.0575
Brugia malayi conserved hypotetical protein 0.0017 0.0011 0.0023
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0011 0.0004
Schistosoma mansoni cpg binding protein 0.003 0.0068 0.0157
Schistosoma mansoni rab6-interacting 0.002 0.0022 0.0052
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0011 0.0037
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0082 0.029 0.1003
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0051 0.0514
Loa Loa (eye worm) hypothetical protein 0.0036 0.0092 0.0319
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0205 0.2365
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0019 0.0017 0.0038
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0231
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0103 0.0097
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0008 0.0014
Loa Loa (eye worm) hypothetical protein 0.0095 0.0348 0.1205
Onchocerca volvulus 0.0017 0.0011 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0037
Echinococcus multilocularis metabotropic glutamate receptor 2 0.009 0.0323 0.0317
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0188 1
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.0865 0.2712
Loa Loa (eye worm) hypothetical protein 0.024 0.0966 0.3346
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0011 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0008 0.0005
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0103 0.0239
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.0042 0.0136
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0188 0.0575
Echinococcus granulosus collagen alpha 1VII chain 0.0044 0.0125 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.004 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0103 0.0307
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0103 0.0239
Loa Loa (eye worm) DR-78 0.0017 0.0011 0.0037
Onchocerca volvulus 0.0753 0.3173 1
Leishmania major cathepsin L-like protease 0.0016 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0036 0.0092 0.0319
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0139
Leishmania major hypothetical protein, conserved 0.0024 0.004 0.0335
Loa Loa (eye worm) glutamate receptor 0.0106 0.0395 0.1367
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.013 0.045
Loa Loa (eye worm) runx1 0.0054 0.017 0.0589
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0185 1
Schistosoma mansoni nuclear receptor 0.0017 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0033
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0019 0.0018 0.0112
Schistosoma mansoni DNA helicase recq1 0.0028 0.006 0.0138
Brugia malayi hypothetical protein 0.0044 0.0125 0.0435
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0008 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.0865 0.2712
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0358
Loa Loa (eye worm) hypothetical protein 0.0036 0.0092 0.0319
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0092 0.0213
Brugia malayi ecdysteroid receptor 0.0036 0.0092 0.0317
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0092 0.0086
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0008 0.0027
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0099 0.0092
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0092 0.0317
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0011 0.0004
Schistosoma mansoni metabotropic glutamate receptor 0.0054 0.0169 0.039
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0389 0.3788
Mycobacterium ulcerans 6-phosphofructokinase 0.0216 0.0865 0.8504
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0092 0.0317
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0358
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0687 0.2887 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0008 0.0082
Schistosoma mansoni cpg binding protein 0.003 0.0068 0.0157
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0205 0.2365
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0008 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.006 0.0053
Brugia malayi hypothetical protein 0.0264 0.107 0.3838
Echinococcus multilocularis Protein lozenge 0.0054 0.017 0.0164
Echinococcus granulosus voltage dependent calcium channel subunit 0.1066 0.4514 0.4511
Toxoplasma gondii microneme protein MIC2 0.0044 0.0125 0.1228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0008 0.0005
Brugia malayi Sulfatase family protein 0.0019 0.0018 0.0049
Toxoplasma gondii microneme protein, putative 0.0015 0.0004 0.004
Echinococcus multilocularis 6 phosphofructokinase 0.0216 0.0865 0.0859
Loa Loa (eye worm) leukotriene A4 hydrolase 0.025 0.1011 0.3503
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0125 0.3465
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0257 0.1041 0.1035
Loa Loa (eye worm) hypothetical protein 0.0044 0.0125 0.0432
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0103 0.0239
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0136 0.128
Plasmodium vivax vivapain-2 0.0016 0.0008 0.0044
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0103 0.0097
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0103 0.0358
Brugia malayi Thioredoxin reductase 0.0046 0.0136 0.0474
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0439 0.4286
Loa Loa (eye worm) hypothetical protein 0.0036 0.0092 0.0319
Brugia malayi nuclear receptor RXR 0.0019 0.0019 0.0055
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0145
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0389 0.3788
Brugia malayi nuclear receptor NHR-88 0.0036 0.0092 0.0317
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0024 0.004 0.0992
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0006 0.0074
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0092 0.0086
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.006 0.0588
Schistosoma mansoni cell polarity protein 0.0024 0.0042 0.0097
Echinococcus multilocularis expressed protein 0.0033 0.0081 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0008 0.0005
Schistosoma mansoni rab6-interacting 0.002 0.0022 0.0052
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0103 0.0239
Brugia malayi hypothetical protein 0.0026 0.0051 0.0167
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0092 0.0317
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0358
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0067
Brugia malayi PXA domain containing protein 0.0039 0.0103 0.0358
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0188 0.0575
Echinococcus granulosus dnaJ subfamily B 0.0409 0.1693 0.1688
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0037
Brugia malayi hypothetical protein 0.002 0.0022 0.0066
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0095 0.0348 0.0342
Loa Loa (eye worm) hypothetical protein 0.0044 0.0125 0.0432
Loa Loa (eye worm) hypothetical protein 0.0431 0.179 0.6199
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0092 0.0086
Echinococcus granulosus 6 phosphofructokinase 0.0216 0.0865 0.0859
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0095 0.0348 0.0342
Trichomonas vaginalis DNA helicase recq, putative 0.0041 0.0112 0.0334
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0103 0.0239
Schistosoma mansoni cpg binding protein 0.0029 0.0061 0.0141
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0216 0.0865 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0099 0.1141
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0019 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0092 0.0319
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0019 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0008 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0103 0.0307
Schistosoma mansoni metabotropic glutamate receptor 0.009 0.0323 0.0747
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0103 0.0358
Brugia malayi 6-phosphofructokinase 0.0216 0.0865 0.3101
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0092 0.0319
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0014
Schistosoma mansoni zinc finger protein 0.0017 0.0011 0.0024
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0061 0.0212
Chlamydia trachomatis glutamine binding protein 0.0019 0.0017 0.0609
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0257 0.1041 0.1035
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0092 0.0317
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0078 0.0707
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1066 0.4514 0.4511
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0136 0.047
Onchocerca volvulus 0.0036 0.0092 0.0277
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0021 0.0026 0.002
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.081 0.3417 0.3413
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0004 0.004
Echinococcus multilocularis musashi 0.0083 0.0296 0.029
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0011 0.0037
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0148 0.1706
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0188 0.0575
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0099 0.0092
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0439 0.1057
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0092 0.0317
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0092 0.0213
Brugia malayi Cathepsin L-like precursor 0.0016 0.0008 0.0014
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0011 0.0024
Plasmodium falciparum glutathione reductase 0.0046 0.0136 0.71
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0019 0.0018 0.0036
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0205 0.2365
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0004 0.004
Trichomonas vaginalis DNA helicase recq, putative 0.0031 0.0071 0.0203
Schistosoma mansoni lipoxygenase 0.0055 0.0175 0.0404
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0358
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0021 0.0026 0.002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0092 0.0317
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0011 0.0004
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0078 0.09
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0008 0.0001
Brugia malayi hypothetical protein 0.0019 0.0019 0.0055
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0101 0.5216
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0006 0.0074
Echinococcus granulosus cathepsin l1 0.0016 0.0008 0.0001
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.0966 0.096
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0008 0.0012
Schistosoma mansoni thyroid hormone receptor 0.0293 0.1195 0.2761
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0021 0.0026 0.002
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0044 0.0125 0.0435
Toxoplasma gondii microneme protein MIC17B 0.0015 0.0004 0.004
Schistosoma mansoni DNA helicase recq5 0.0028 0.006 0.0138
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0092 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0205 0.2309
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0019 0.0017 0.011
Echinococcus multilocularis pikachurin 0.0024 0.0042 0.0035
Brugia malayi von Willebrand factor type A domain containing protein 0.0044 0.0125 0.0435
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0019 0.0013
Brugia malayi Zona pellucida-like domain containing protein 0.0044 0.0125 0.0435
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.1693 0.1688
Leishmania major ATP-dependent phosphofructokinase 0.0216 0.0865 0.8504
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0014
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0011 0.0023
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0011 0.0024
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0515 0.2151 0.497
Brugia malayi laminin alpha chain 0.0024 0.0042 0.0136
Onchocerca volvulus 0.0029 0.0061 0.018
Leishmania major cathepsin L-like protease 0.0016 0.0008 0.0015
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.006 0.0053
Schistosoma mansoni hypothetical protein 0.0049 0.0148 0.0341
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0011 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0008 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Brugia malayi nuclear receptor NHR-88 0.0017 0.0011 0.0023
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0058 0.0188 0.1854
Echinococcus granulosus geminin 0.0169 0.0665 0.0659
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0006 0.0063
Schistosoma mansoni hypothetical protein 0.002 0.0022 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0095 0.0348 0.0804
Brugia malayi von Willebrand Factor 0.0044 0.0125 0.0435
Mycobacterium tuberculosis Possible hydrolase 0.0019 0.0018 0.0112
Echinococcus multilocularis tissue type plasminogen activator 0.0024 0.004 0.0034
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0083 0.0296 0.1026
Leishmania major cathepsin L-like protease 0.0016 0.0008 0.0015
Onchocerca volvulus 0.0016 0.0008 0.0012
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0019 0.0018 0.0112
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0103 0.0097
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0037
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0103 0.0358
Echinococcus granulosus metabotropic glutamate receptor 2 0.009 0.0323 0.0317
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0011 0.0023
Schistosoma mansoni hypothetical protein 0.0044 0.0125 0.0288
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Onchocerca volvulus 0.0044 0.0125 0.0381
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0111 0.0104
Schistosoma mansoni ap endonuclease 0.0058 0.0185 0.0427
Leishmania major cathepsin L-like protease 0.0016 0.0008 0.0015
Schistosoma mansoni ap endonuclease 0.0058 0.0185 0.0427
Echinococcus granulosus pikachurin 0.0024 0.0042 0.0035
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0185 0.5226
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0103 0.0097
Schistosoma mansoni lamin 0.0083 0.0296 0.0685
Loa Loa (eye worm) ctsf protein 0.0016 0.0008 0.0027
Loa Loa (eye worm) hypothetical protein 0.0044 0.0125 0.0432
Loa Loa (eye worm) hypothetical protein 0.0036 0.0092 0.0319
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0186 0.1834
Echinococcus granulosus GPCR family 3 C terminal 0.0017 0.0009 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0205 0.2309
Echinococcus multilocularis metabotropic glutamate receptor 5 0.013 0.0497 0.049
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0008 0.0082
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0008 0.0082
Loa Loa (eye worm) hypothetical protein 0.013 0.0497 0.172
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.1016 1
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0103 0.0239
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0185 0.0651
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0039 0.0103 0.0307
Brugia malayi intermediate filament protein 0.0083 0.0296 0.1052
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0103 0.0097
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.0865 0.2712
Schistosoma mansoni hypothetical protein 0.0169 0.0665 0.1537
Onchocerca volvulus 0.0431 0.179 0.5636
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0014
Brugia malayi Pre-SET motif family protein 0.0662 0.278 1
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0103 0.0358
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0044 0.0125 0.6504
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0216 0.0865 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0008 0.0027
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0004 0.0014
Brugia malayi PXA domain containing protein 0.0039 0.0103 0.0358
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0092 0.0319
Echinococcus multilocularis GPCR, family 3, C terminal 0.0017 0.0009 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0008 0.0005
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0103 0.0239
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0051 0.0584
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0099 0.0291
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0185 0.2079
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.005 0.0116
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0014
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0185 0.2137
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.0181
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0103 0.0097
Loa Loa (eye worm) phosphofructokinase 0.0216 0.0865 0.2996
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0216 0.0865 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0205 0.2309
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0014
Echinococcus multilocularis glutamate receptor 2 0.0021 0.0026 0.002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0092 0.0213
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0185 0.9808
Echinococcus multilocularis slit 2 protein 0.0024 0.0042 0.0035
Brugia malayi Cathepsin L-like precursor 0.0016 0.0008 0.0014
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.006 0.0207
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0662 0.278 0.963
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0205 0.2309
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0006 0.0074
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0026 0.0049 0.0042
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0011 0.0004
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0006 0.0015
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.0042 0.0035
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.0044 0.0125 0.0432
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0092 0.0319
Echinococcus multilocularis geminin 0.0169 0.0665 0.0659
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1022 0.4327 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0011 0.0004
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0078 0.0832
Echinococcus multilocularis nmda type glutamate receptor 0.0026 0.0049 0.0042
Toxoplasma gondii hypothetical protein 0.0015 0.0004 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0092 0.0317
Onchocerca volvulus 0.0044 0.0125 0.0381
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0008 0.0012
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0092 0.0277
Entamoeba histolytica hypothetical protein 0.0037 0.0099 0.1141
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0022 0.0016
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.006 0.2932
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0103 0.0097
Toxoplasma gondii cathepsin CPL 0.0016 0.0008 0.0078
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0019 0.0017 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Echinococcus granulosus tumor protein p63 0.0352 0.1448 0.1443
Brugia malayi EGF-like domain containing protein 0.0024 0.0042 0.0136
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0017 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.0044 0.0125 0.0432
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0008 0.0001
Loa Loa (eye worm) glutathione reductase 0.0046 0.0136 0.047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0008 0.0005
Trichomonas vaginalis set domain proteins, putative 0.0753 0.3173 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0185 0.1768
Brugia malayi Receptor family ligand binding region containing protein 0.003 0.0067 0.0226
Plasmodium falciparum thrombospondin-related anonymous protein 0.0044 0.0125 0.6504
Brugia malayi Zona pellucida-like domain containing protein 0.0044 0.0125 0.0435
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0011 0.0037
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0021 0.0026 0.002
Brugia malayi glutathione reductase 0.0046 0.0136 0.0474
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.0083 0.0296 0.1026
Loa Loa (eye worm) fibroinase 0.0016 0.0008 0.0027
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0092 0.0086
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0103 0.0097
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0008 0.0005
Brugia malayi hypothetical protein 0.0037 0.0099 0.0341
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0136 0.1567
Brugia malayi ecdysone receptor 0.0017 0.0011 0.0023
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0099 0.1141
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0205 0.2309
Entamoeba histolytica recQ family helicase, putative 0.0031 0.0071 0.0816
Brugia malayi hypothetical protein 0.0431 0.179 0.6432
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0022 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0044 0.0125 0.0432
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0093 0.0337 0.12
Loa Loa (eye worm) CUTiclin-Like family member 0.0044 0.0125 0.0432
Mycobacterium ulcerans arylsulfatase, AslA 0.0019 0.0018 0.0112
Echinococcus granulosus tissue type plasminogen activator 0.0024 0.004 0.0034
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0004 0.004
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0103 0.0358
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.025 0.1011 0.2337
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0185 0.2137
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0092 0.0319
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0008 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.0865 0.2712
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0078 0.0766
Toxoplasma gondii kringle domain-containing protein 0.0024 0.004 0.0396
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2344 1 1
Onchocerca volvulus 0.0016 0.0008 0.0012
Entamoeba histolytica hypothetical protein 0.0037 0.0099 0.1141
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0103 0.0358
Loa Loa (eye worm) cytochrome P450 family protein 0.0077 0.0269 0.0933
Entamoeba histolytica hypothetical protein 0.0037 0.0099 0.1141
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0348 0.0804
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0251 0.1016 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0125 0.0432
Echinococcus granulosus cpg binding protein 0.003 0.0068 0.0062
Toxoplasma gondii exonuclease III APE 0.0058 0.0185 0.1819
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0006 0.0008
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0044 0.0125 0.3465
Loa Loa (eye worm) RecQ helicase 0.0041 0.0112 0.0388
Schistosoma mansoni survival motor neuron protein 0.0049 0.0148 0.0341
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.1016 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0021 0.0026 0.002
Schistosoma mansoni nuclear receptor 0.0017 0.0011 0.0024
Echinococcus multilocularis lamin 0.0083 0.0296 0.029
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0188 0.0575
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0022 0.0016
Entamoeba histolytica phosphofructokinase, putative 0.0216 0.0865 1
Loa Loa (eye worm) hypothetical protein 0.0472 0.1964 0.6802
Echinococcus multilocularis expressed protein 0.0751 0.3163 0.3158
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0117 0.0439 0.1015
Brugia malayi Metabotropic glutamate receptor precursor. 0.0106 0.0395 0.1407
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0019 0.0017 0.0609
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0092 0.0086
Plasmodium vivax vivapain-2 0.0016 0.0008 0.0044
Entamoeba histolytica hypothetical protein, conserved 0.0044 0.0125 0.1442
Onchocerca volvulus 0.0049 0.0148 0.0453
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0011 0.0024
Loa Loa (eye worm) 6-phosphofructokinase 0.0216 0.0865 0.2996
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0008 0.0005
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0103 0.0097
Leishmania major cathepsin L-like protease 0.0062 0.0205 0.1963
Entamoeba histolytica phosphofructokinase, putative 0.0216 0.0865 1
Echinococcus multilocularis cysteine protease 0.0016 0.0008 0.0001
Schistosoma mansoni aldehyde dehydrogenase 0.0251 0.1016 0.2348
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0185 0.064
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0051 0.0584
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0091 0.033 0.0324
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0092 0.0213
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0103 0.0239
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0044 0.0125 0.3465
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0058 0.0188 1
Onchocerca volvulus 0.0017 0.0011 0.0021
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0103 0.0097
Loa Loa (eye worm) CUTiclin family member 0.0044 0.0125 0.0432
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0103 0.0239
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0103 0.0097
Schistosoma mansoni lamin 0.0083 0.0296 0.0685
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0015 0.0004 0.004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0348 0.0804
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.0042 0.0097
Brugia malayi hypothetical protein 0.0017 0.0011 0.0024
Schistosoma mansoni hypothetical protein 0.0551 0.2301 0.5318
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0092 0.0086
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0051 0.2426
Brugia malayi Cathepsin L-like precursor 0.0016 0.0008 0.0014
Brugia malayi von Willebrand factor type A domain containing protein 0.0044 0.0125 0.0435
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0251 0.1016 1
Onchocerca volvulus 0.0095 0.0348 0.1085
Brugia malayi Cache domain containing protein 0.0472 0.1964 0.7059
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0006 0.0074
Trichomonas vaginalis rotamase, putative 0.0033 0.0081 0.0236
Brugia malayi von Willebrand factor type A domain containing protein 0.0044 0.0125 0.0435
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0175
Brugia malayi Bloom's syndrome protein homolog 0.0041 0.0112 0.0389
Brugia malayi hypothetical protein 0.0017 0.0011 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0092 0.0319
Schistosoma mansoni serine-rich repeat protein 0.0551 0.2301 0.5318
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.013 0.0453
Plasmodium vivax glutathione reductase, putative 0.0046 0.0136 0.3783
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0185 0.0402
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0103 0.0358
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0008 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0067
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0019 0.0055
Loa Loa (eye worm) hypothetical protein 0.0036 0.0092 0.0319
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0071 0.0816
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0092 0.0319
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0019 0.0017 0.0038
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0216 0.0865 0.1882
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1085 0.4596 1
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0103 0.0239
Echinococcus granulosus leukotriene A 4 hydrolase 0.025 0.1011 0.1006
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0019 0.0067
Brugia malayi von Willebrand factor type A domain containing protein 0.0044 0.0125 0.0435
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0044 0.0125 0.0374
Onchocerca volvulus 0.002 0.0022 0.0058
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0051 0.0497
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0006 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0008 0.0005
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0022 0.0884
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0099 0.0092
Brugia malayi 6-phosphofructokinase 0.0216 0.0865 0.3101
Mycobacterium ulcerans arylsulfatase AtsD 0.0019 0.0018 0.0112
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0099 0.0092
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0037
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0099 0.5072
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.003 0.0067 0.0231
Toxoplasma gondii thioredoxin reductase 0.0046 0.0136 0.1334
Brugia malayi hypothetical protein 0.0019 0.0018 0.0049
Echinococcus multilocularis cpg binding protein 0.003 0.0068 0.0062
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0103 0.0097
Plasmodium falciparum cysteine repeat modular protein 1 0.0024 0.004 0.1861
Schistosoma mansoni aldehyde dehydrogenase 0.0251 0.1016 0.2348
Echinococcus multilocularis thyroid hormone receptor alpha 0.0293 0.1195 0.1189
Loa Loa (eye worm) hypothetical protein 0.0036 0.0092 0.0319
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0348 0.0804
Brugia malayi hypothetical protein 0.0115 0.0431 0.1539
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0439 0.4286
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0008 0.0005
Echinococcus multilocularis lamin dm0 0.0083 0.0296 0.029
Entamoeba histolytica hypothetical protein 0.0039 0.0103 0.1196
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0103 0.0358
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0006 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036
Schistosoma mansoni hypothetical protein 0.0037 0.0099 0.0228
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.0044 0.0125 0.0432
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0044 0.0125 0.1228
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0099 0.0228
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0099 0.0291
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0008 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0078
Schistosoma mansoni lozenge 0.0054 0.017 0.0393
Brugia malayi Doublecortin family protein 0.002 0.0022 0.0066
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0008 0.0001
Brugia malayi von Willebrand factor type A domain containing protein 0.0044 0.0125 0.0435
Trypanosoma brucei trypanothione reductase 0.0046 0.0136 0.1505
Onchocerca volvulus 0.0024 0.004 0.0114
Echinococcus granulosus nmda type glutamate receptor 0.0026 0.0049 0.0042
Schistosoma mansoni slit 0.0024 0.0042 0.0097
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0037
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0051 0.1293
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.0042 0.0145
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.0042 0.0035
Brugia malayi Protein kinase domain containing protein 0.0024 0.004 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0036

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 9 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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