Detailed information for compound 1100520

Basic information

Technical information
  • TDR Targets ID: 1100520
  • Name: N-phenyl-1-[1-(phenylmethyl)benzimidazol-2-yl ]diazenylnaphthalen-2-amine
  • MW: 453.537 | Formula: C30H23N5
  • H donors: 1 H acceptors: 1 LogP: 7.94 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)Nc1ccc2c(c1N=Nc1nc3c(n1Cc1ccccc1)cccc3)cccc2
  • InChi: 1S/C30H23N5/c1-3-11-22(12-4-1)21-35-28-18-10-9-17-26(28)32-30(35)34-33-29-25-16-8-7-13-23(25)19-20-27(29)31-24-14-5-2-6-15-24/h1-20,31H,21H2
  • InChiKey: DAEPSCKFIWDJAQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-phenyl-1-[1-(phenylmethyl)benzimidazol-2-yl]azo-naphthalen-2-amine
  • N-phenyl-1-[[1-(phenylmethyl)-2-benzimidazolyl]azo]-2-naphthalenamine
  • [1-[1-(benzyl)benzimidazol-2-yl]azo-2-naphthyl]-phenyl-amine
  • N-phenyl-1-[1-(phenylmethyl)benzimidazol-2-yl]diazenyl-naphthalen-2-amine
  • ZINC03876656
  • AE-848/30862064

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum mitogen-activated protein kinase 2 Starlite/ChEMBL No references
Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 1 Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 6 Starlite/ChEMBL No references
Leishmania mexicana glucose transporter, lmgt2 Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 7 Starlite/ChEMBL No references
Plasmodium falciparum calcium-dependent protein kinase 1 Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Proline--tRNA ligase Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Calcium-dependent protein kinase 4 Starlite/ChEMBL No references
Plasmodium falciparum hexose transporter Starlite/ChEMBL No references
Plasmodium falciparum lysine--tRNA ligase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania major glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium yoelii calcium-dependent protein kinase-3 Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 2 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K04567 lysyl-tRNA synthetase, class II, putative Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium yoelii cdk-related protein kinase 6-related Get druggable targets OG5_155179 All targets in OG5_155179
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Toxoplasma gondii calcium-dependent protein kinase CDPK2A Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 4, putative Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania major protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Leishmania infantum glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II alpha chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium hominis aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Toxoplasma gondii lysine-tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania mexicana glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii putative sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania major lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania infantum glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus multilocularis calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Leishmania donovani glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II beta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium knowlesi calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium falciparum protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Theileria parva mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Brugia malayi Cam kinase protein 1 Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calcium-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Babesia bovis mitogen-activated protein kinase, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium yoelii mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium hominis CDPK2 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum calmodulin-domain protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum CMGC kinase, MAPK family, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium berghei calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium berghei protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania donovani glucose transporter 3, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium berghei mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania donovani protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii Plasmodium falciparum CDPK2 protein Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii Ser/Thr protein kinase Get druggable targets OG5_145294 All targets in OG5_145294
Leishmania donovani lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium falciparum calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K07191 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Babesia bovis lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania infantum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium hominis Kars protein Get druggable targets OG5_126972 All targets in OG5_126972
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II delta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium vivax calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calmodulin-domain protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 3, putative Get druggable targets OG5_127135 All targets in OG5_127135
Brugia malayi lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium knowlesi lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium falciparum proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Toxoplasma gondii protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Plasmodium vivax proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter 2A Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania infantum glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K07299 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium knowlesi CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Toxoplasma gondii facilitative glucose transporter GT1 Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma cruzi hexose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Entamoeba histolytica prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi protein kinase 7, putative Get druggable targets OG5_145294 All targets in OG5_145294
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calmodulin-domain protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Loa Loa (eye worm) sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Neospora caninum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum IPR005828,General substrate transporter,domain-containing Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Loa Loa (eye worm) CAMK/CAMK2 protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis solute carrier family 2, facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum ko:K01881 prolyl-tRNA synthetase [EC6.1.1.15], putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Mycobacterium leprae Probable prolyl tRNA synthetase ProS Get druggable targets OG5_127154 All targets in OG5_127154
Theileria parva calmodulin-domain protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium vivax hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium vivax lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium knowlesi calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium yoelii prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei gambiense glucose transporter,glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense glucose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium yoelii lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Theileria parva lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Cryptosporidium parvum mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Neospora caninum Glucose transporter 1A, related Get druggable targets OG5_127135 All targets in OG5_127135
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter 1E Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum expressed protein Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calmodulin-like domain protein kinase isoenzyme gamma, related Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Chlamydia trachomatis lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Cryptosporidium parvum lysyl-tRNA synthetase (NOB+tRNA synthetase) Get druggable targets OG5_126972 All targets in OG5_126972
Toxoplasma gondii calcium-dependent protein kinase CDPK2B Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Schistosoma japonicum ko:K08794 calcium/calmodulin-dependent protein kinase I, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania infantum glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania mexicana glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii calcium-dept. protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum Calcium-dependent protein kinase 2, related Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum IPR000924,Glutamyl-tRNA synthetase, class Ic;IPR001412,Aminoacyl-tRNA synthetase, class I,domain-containing Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma cruzi lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium knowlesi calcium-dependent protein kinase 5, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium knowlesi hexose transporter, putative Get druggable targets OG5_127135 All targets in OG5_127135
Candida albicans hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium falciparum mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania braziliensis lmgt2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani glucose transporter 1 Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium knowlesi calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium knowlesi proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum protein kinase, PfPK7 homolog, putative Get druggable targets OG5_145294 All targets in OG5_145294
Giardia lamblia Lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Brugia malayi Sugar transporter family protein Get druggable targets OG5_127135 All targets in OG5_127135
Babesia bovis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Brugia malayi bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Giardia lamblia Prolyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum proline-tRNA synthetase; class II aaRS (ybak RNA binding domain plus tRNA synthetase) Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 1, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Cryptosporidium parvum hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Entamoeba histolytica protein kinase, putative Calcium-dependent protein kinase 4   528 aa 429 aa 26.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 protein kinase 6 305 aa 338 aa 27.2 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 499 aa 29.3 %
Neospora caninum CAM kinase, CDPK family, putative Calcium-dependent protein kinase 4   528 aa 463 aa 32.0 %
Leishmania donovani protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Trypanosoma brucei glucose transporter, putative hexose transporter 504 aa 426 aa 22.3 %
Trypanosoma brucei gambiense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Trypanosoma brucei protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 28.8 %
Babesia bovis mitogen-activated protein kinase, putative Calcium-dependent protein kinase 4   528 aa 427 aa 23.4 %
Cryptosporidium hominis hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Trypanosoma brucei protein lipid droplet kinase (LDK) protein kinase 7 343 aa 310 aa 25.2 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Calcium-dependent protein kinase 4   528 aa 468 aa 35.9 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 29.0 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 522 aa 25.5 %
Neospora caninum Calcium-dependent protein kinase, related Calcium-dependent protein kinase 4   528 aa 516 aa 35.5 %
Leishmania braziliensis protein kinase, putative Calcium-dependent protein kinase 4   528 aa 490 aa 27.3 %
Cryptosporidium hominis calmodulin-domain protein kinase 2 Calcium-dependent protein kinase 4   528 aa 468 aa 36.1 %
Toxoplasma gondii calcium-dependent protein kinase CDPK6 Calcium-dependent protein kinase 4   528 aa 453 aa 34.0 %
Leishmania infantum protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Toxoplasma gondii calcium-dependent protein kinase CDPK9 Calcium-dependent protein kinase 4   528 aa 500 aa 34.2 %
Leishmania mexicana protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.2 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 527 aa 25.6 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 517 aa 27.9 %
Toxoplasma gondii calcium-dependent protein kinase CDPK2 Calcium-dependent protein kinase 4   528 aa 480 aa 36.9 %
Theileria parva calmodulin-domain protein kinase, putative Calcium-dependent protein kinase 4   528 aa 454 aa 31.9 %
Trypanosoma brucei glucose transporter, putative solute carrier family 2 (facilitated glucose transporter), member 1 492 aa 395 aa 23.5 %
Giardia lamblia Kinase, NEK Calcium-dependent protein kinase 4   528 aa 509 aa 19.8 %
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Cryptosporidium hominis calcium-dependent protein kinase Calcium-dependent protein kinase 4   528 aa 502 aa 29.7 %
Leishmania major protein kinase, putative Calcium-dependent protein kinase 4   528 aa 488 aa 27.5 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands Calcium-dependent protein kinase 4   528 aa 501 aa 28.9 %
Theileria parva protein kinase, putative Calcium-dependent protein kinase 4   528 aa 507 aa 27.4 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 509 aa 25.5 %
Babesia bovis calcium-dependent protein kinase, putative Calcium-dependent protein kinase 4   528 aa 450 aa 30.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni protein kinase 0.0039 0.0427 0.0736
Brugia malayi RNA, U transporter 1 0.0083 0.0989 0.1274
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0006 0.0018 0.0021
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0373 0.048
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0133 0.2039
Onchocerca volvulus 0.0233 0.2887 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0433 0.1254
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.131 0.1687
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0163 0.0472
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0497 0.7952
Echinococcus granulosus importin 5 0.0006 0.0009 0.0002
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2887 0.835
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Onchocerca volvulus 0.0015 0.0128 0.0419
Plasmodium vivax glycine--tRNA ligase, putative 0.0007 0.0029 0.003
Giardia lamblia Sugar-proton symporter 0.0018 0.0163 0.346
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0133 0.1914
Onchocerca volvulus 0.0018 0.0163 0.0542
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0007 0.0029 0.0083
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0133 0.2039
Mycobacterium tuberculosis Probable reductase 0.0101 0.1219 0.3603
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.062 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.062 0.0912
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0101 0.1219 0.3603
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0007 0.0029 0.0037
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0318 0.0401
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0433 0.1254
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Trichomonas vaginalis hypothetical protein 0.0006 0.0009 0.0025
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0133 0.3933
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Brugia malayi glutathione reductase 0.0044 0.05 0.0644
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0133 0.0172
Onchocerca volvulus 0.0032 0.0344 0.1171
Loa Loa (eye worm) G protein alpha subunit 3 0.0006 0.0017 0.0022
Loa Loa (eye worm) sugar transporter 0.0126 0.1534 0.1976
Brugia malayi Melatonin receptor type 1A 0.0005 0.0007 0.0009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.176 0.226
Brugia malayi Pre-SET motif family protein 0.003 0.0318 0.041
Brugia malayi glycyl-tRNA synthetase 0.0007 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0218 0.3422
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0218 0.3319
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0163 0.021
Brugia malayi G protein-coupled receptor F59B2.13 0.0005 0.0007 0.0009
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0053 0.0046
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0238 0.0689
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0039 0.0427 0.0625
Leishmania major hypothetical protein, conserved 0.0054 0.062 1
Echinococcus granulosus Threonyl tRNA synthetase C 0.0007 0.0029 0.0028
Brugia malayi hypothetical protein 0.0035 0.0379 0.0488
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0039 0.0427 0.0625
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0006 0.0017 0.001
Toxoplasma gondii glycyl-tRNA synthetase 0.0007 0.0029 0.0045
Echinococcus multilocularis dnaJ subfamily B 0.0457 0.5715 0.5712
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0211 0.4682
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0031 0.0089
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Trypanosoma cruzi sugar transporter, putative 0.0018 0.0163 0.2409
Brugia malayi neuropeptide F receptor 0.0005 0.0007 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0815 0.1415
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0017 0.0022
Echinococcus granulosus transportin 1 0.0006 0.0009 0.0002
Brugia malayi Sugar transporter family protein 0.0018 0.0163 0.021
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0007 0.0029 0.0326
Onchocerca volvulus 0.0018 0.0163 0.0542
Onchocerca volvulus Arrow homolog 0.0015 0.0128 0.0419
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0427 0.042
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Brugia malayi Pre-SET motif family protein 0.0205 0.253 0.3259
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0433 0.1254
Plasmodium vivax threonine--tRNA ligase, putative 0.0007 0.0029 0.003
Leishmania major glucose transporter, lmgt3 0.0039 0.0433 0.695
Brugia malayi hypothetical protein 0.0018 0.0163 0.021
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1534 0.1527
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0006 0.0017 0.0017
Schistosoma mansoni sugar transporter 0.0018 0.0163 0.0273
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.0029 0.0174
Toxoplasma gondii facilitative glucose transporter GT1 0.0126 0.1534 0.3438
Schistosoma mansoni ap endonuclease 0.0022 0.0218 0.0369
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0133 0.0386
Leishmania major protein kinase, putative 0.0039 0.0427 0.6848
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Echinococcus granulosus General substrate transporter 0.0108 0.1309 0.1679
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0015 0.0128 0.0121
Loa Loa (eye worm) hypothetical protein 0.0074 0.0876 0.1129
Plasmodium vivax importin-beta 2, putative 0.0029 0.0308 0.0447
Plasmodium falciparum importin beta, putative 0.0029 0.0308 0.0447
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0473 0.3385
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0015 0.0128 0.0121
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0022
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0295 0.0288
Plasmodium falciparum calcium-dependent protein kinase 2 0.0039 0.0427 0.0625
Trichomonas vaginalis esterase, putative 0.0042 0.0473 0.1368
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0015 0.0128 0.0211
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0218 0.4997
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0244 0.0306
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Echinococcus granulosus expressed protein 0.0006 0.0017 0.0013
Echinococcus multilocularis transportin 1 0.0006 0.0009 0.0002
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0433 0.1254
Echinococcus multilocularis muscleblind protein 0.0619 0.7762 0.7761
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Entamoeba histolytica Ran family GTPase 0.0022 0.0211 0.4824
Trichomonas vaginalis myo-inositol transporter, putative 0.0018 0.0163 0.0472
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.3457 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0373 0.0366
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0473 0.1365
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0251 0.0726
Trypanosoma brucei sugar transporter, putative 0.0018 0.0163 0.2527
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0082 0.0105
Echinococcus granulosus solute carrier family 22 0.0018 0.0163 0.0201
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0133 0.1914
Schistosoma mansoni protein kinase 0.0039 0.0427 0.0736
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.0108 0.1973
Brugia malayi basement membrane proteoglycan precursor 0.0015 0.0128 0.0165
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0015 0.0128 0.0419
Entamoeba histolytica hypothetical protein 0.0024 0.0238 0.5485
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2247 0.6501
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0101 0.1219 0.3603
Loa Loa (eye worm) G-protein coupled receptor 0.0005 0.0007 0.0009
Entamoeba histolytica protein kinase, putative 0.0039 0.0427 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0005 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0015 0.0128 0.0121
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Onchocerca volvulus 0.0006 0.0017 0.0035
Schistosoma mansoni hypothetical protein 0.0015 0.0128 0.0211
Schistosoma mansoni hypothetical protein 0.0074 0.0876 0.1522
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0373 0.048
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0133 0.0186
Loa Loa (eye worm) TYRA-2 protein 0.0005 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Plasmodium vivax glutathione reductase, putative 0.0044 0.05 0.0733
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0211 0.3198
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0296 0.0372
Echinococcus granulosus solute carrier family 22 0.0018 0.0163 0.0201
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2247 0.6501
Onchocerca volvulus 0.0006 0.0017 0.0035
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0497 0.7983
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0318 0.0545
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0006 0.0017 0.0022
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0007 0.0029 0.0078
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.253 0.3259
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1534 0.1968
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0373 0.0471
Mycobacterium tuberculosis Possible penicillin-binding protein 0.027 0.3351 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0133 0.2039
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0163 0.2527
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0473 0.1368
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0295 0.2059
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0015 0.0128 0.0165
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0473 0.1365
Mycobacterium tuberculosis Conserved protein 0.0042 0.0473 0.1365
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0053 0.0046
Echinococcus multilocularis solute carrier family 22 0.0018 0.0163 0.0156
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Toxoplasma gondii thioredoxin reductase 0.0044 0.05 0.1108
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0005 0.0007 0.0009
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0133 0.1914
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0022
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0076 0.0098
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0006 0.0018 0.0155
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.3457 1
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0473 1
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0433 0.6902
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Schistosoma mansoni ran 0.0022 0.0211 0.0356
Chlamydia trachomatis proline--tRNA ligase 0.0013 0.0108 0.2978
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0007 0.0029 0.0021
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0006 0.0017 0.0022
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0295 0.6084
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0018 0.0053
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0006 0.0017 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0089
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0218 0.4391
Loa Loa (eye worm) hypothetical protein 0.0042 0.0473 0.0609
Schistosoma mansoni hypothetical protein 0.0034 0.0373 0.064
Onchocerca volvulus 0.0006 0.0017 0.0035
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0007 0.0029 0.023
Trypanosoma cruzi glucose transporter, putative 0.0018 0.0163 0.2409
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.0108 0.4189
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2247 0.6501
Brugia malayi enteropeptidase precursor 0.0015 0.0128 0.0165
Onchocerca volvulus 0.0018 0.0163 0.0542
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0006 0.0017 0.0017
Mycobacterium ulcerans hypothetical protein 0.0042 0.0473 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Trypanosoma brucei glucose transporter, putative 0.0039 0.0433 0.695
Echinococcus multilocularis muscleblind protein 1 0.0619 0.7762 0.7761
Schistosoma mansoni glycyl-tRNA synthetase 0.0007 0.0029 0.0038
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0308 0.4898
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Schistosoma mansoni hypothetical protein 0.0015 0.0128 0.0211
Brugia malayi Tachykinin-like peptides receptor 99D 0.0005 0.0007 0.0009
Loa Loa (eye worm) neuropeptide F receptor 0.0005 0.0007 0.0009
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0133 0.0221
Brugia malayi Importin beta-1 subunit 0.0029 0.0308 0.0397
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0427 0.0542
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0006 0.0017 0.0017
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0433 0.695
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0006 0.0017 0.0017
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0007 0.0029 0.0045
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Leishmania major hypothetical protein, conserved 0.0006 0.0018 0.0155
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0133 0.0163
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0218 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0133 0.0186
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0473 0.0601
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0815 0.105
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0031 0.0328 0.0422
Brugia malayi Dopamine receptor protein 1 0.0005 0.0007 0.0009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0053 0.0059
Leishmania major myo-inositol/proton symporter (MIT) 0.0018 0.0163 0.2527
Onchocerca volvulus 0.0018 0.0163 0.0542
Echinococcus multilocularis General substrate transporter 0.0108 0.1309 0.1303
Echinococcus granulosus snurportin 1 0.0312 0.388 0.4993
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Echinococcus granulosus solute carrier family 22 0.0018 0.0163 0.0201
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0473 0.1368
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0133 0.2039
Echinococcus multilocularis expressed protein 0.0006 0.0017 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0318 0.0545
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0006 0.0017 0.005
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0018 0.0163 0.0435
Entamoeba histolytica protein kinase, putative 0.0039 0.0427 1
Toxoplasma gondii sugar transporter ST3 0.0018 0.0163 0.0348
Plasmodium falciparum calcium-dependent protein kinase 4 0.0039 0.0427 0.0625
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0015 0.0128 0.0121
Trypanosoma brucei glucose transporter 1E 0.0039 0.0433 0.695
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0163 0.0472
Echinococcus granulosus low density lipoprotein receptor ldl 0.0015 0.0128 0.0155
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0397 0.0503
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0815 0.0808
Mycobacterium tuberculosis Conserved protein 0.0042 0.0473 0.1365
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0295 0.0504
Schistosoma mansoni glucose transport protein 0.0126 0.1534 0.2674
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0038 0.0417 0.9764
Loa Loa (eye worm) hypothetical protein 0.0042 0.0473 0.0609
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0038 0.0417 0.0529
Brugia malayi RE15519p 0.0005 0.0007 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.2372 0.686
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0133 0.2694
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.0497 0.0728
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0163 0.021
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0308 0.4898
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.05 0.0733
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0295 0.0427
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0006 0.0017 0.0013
Echinococcus multilocularis importin 5 0.0006 0.0009 0.0002
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.062 0.1378
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0005 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.0126 0.1534 0.2674
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0473 0.1365
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2247 0.6501
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0427 0.0542
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0295 0.038
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0039 0.0427 0.0542
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.3457 1
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.0029 0.0174
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0218 0.0281
Brugia malayi larval opioid receptor 0.0005 0.0007 0.0009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.176 0.1754
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Brugia malayi putative neuropeptide receptor 0.0005 0.0007 0.0009
Trypanosoma brucei glucose transporter, putative 0.0039 0.0433 0.695
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.131 0.1687
Loa Loa (eye worm) hypothetical protein 0.0038 0.0417 0.0538
Brugia malayi beta-lactamase family protein 0.0042 0.0473 0.0609
Onchocerca volvulus 0.0042 0.0473 0.1617
Chlamydia trachomatis lysine--tRNA ligase 0.0028 0.0295 1
Echinococcus multilocularis glycyl tRNA synthetase 0.0007 0.0029 0.0021
Schistosoma mansoni cpg binding protein 0.0034 0.0368 0.0631
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0473 0.1368
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0163 0.0201
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0016 0.0135 0.0174
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0006 0.0017 0.005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.176 0.226
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0017 0.0017
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0417 0.0719
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0018 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.176 0.3071
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Trypanosoma brucei glucose transporter, putative 0.0039 0.0433 0.695
Toxoplasma gondii ABC1 family protein 0.0042 0.0473 0.1047
Brugia malayi GnHR receptor homolog 0.0005 0.0007 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0089
Schistosoma mansoni hypothetical protein 0.0034 0.0373 0.064
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0007 0.0029 0.0037
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0211 0.0262
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0211 0.0271
Brugia malayi major facilitator superfamily protein 0.0018 0.0163 0.021
Echinococcus granulosus geminin 0.0183 0.2256 0.2899
Plasmodium falciparum protein kinase 6 0.0536 0.6707 1
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0007 0.0029 0.0037
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0163 0.021
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0006 0.0017 0.001
Trypanosoma brucei glucose transporter, putative 0.0039 0.0433 0.695
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0089
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0133 0.1914
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0037
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Brugia malayi Cam kinase protein 1 0.0039 0.0427 0.055
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0089
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0473 0.0693
Echinococcus granulosus GPCR family 2 0.0034 0.0373 0.0471
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0015 0.0128 0.0211
Echinococcus granulosus basement membrane specific heparan sulfate 0.0015 0.0128 0.0155
Loa Loa (eye worm) hypothetical protein 0.003 0.0318 0.041
Echinococcus granulosus importin subunit beta 1 0.0029 0.0308 0.0388
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0295 0.6849
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.062 0.0912
Onchocerca volvulus 0.0042 0.0473 0.1617
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.176 0.2268
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0295 0.6084
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.3457 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0295 0.4682
Plasmodium vivax hexose transporter 0.0126 0.1534 0.2276
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0238 0.3658
Mycobacterium tuberculosis Probable dehydrogenase 0.0101 0.1219 0.3603
Echinococcus granulosus basement membrane specific heparan sulfate 0.0015 0.0128 0.0155
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0204 0.2516 0.3743
Trypanosoma cruzi hexose transporter 0.0039 0.0433 0.6902
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0497 0.7983
Schistosoma mansoni ap endonuclease 0.0022 0.0218 0.0369
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0204 0.2516 0.5652
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.1534 0.4436
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Plasmodium falciparum thioredoxin reductase 0.0015 0.0133 0.0186
Onchocerca volvulus 0.0018 0.0163 0.0542
Brugia malayi hypothetical protein 0.0054 0.062 0.0799
Schistosoma mansoni importin beta-1 0.0029 0.0308 0.0527
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0218 0.0312
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0815 0.1415
Brugia malayi hypothetical protein 0.0006 0.0017 0.0022
Leishmania major threonyl-tRNA synthetase, putative 0.0007 0.0029 0.0326
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0007 0.0029 0.0475
Brugia malayi Dopamine receptor 0.0005 0.0007 0.0009
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0007 0.0029 0.0037
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0133 0.0386
Echinococcus granulosus tar DNA binding protein 0.0069 0.0815 0.1041
Plasmodium falciparum calcium-dependent protein kinase 3 0.0039 0.0427 0.0625
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0295 0.0853
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2247 0.6501
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.176 0.3071
Schistosoma mansoni hypothetical protein 0.0183 0.2256 0.3939
Plasmodium vivax CDK-related protein kinase 6, putative 0.0536 0.6707 1
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0006 0.0017 0.0022
Loa Loa (eye worm) hypothetical protein 0.0619 0.7762 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0218 1
Giardia lamblia Prolyl-tRNA synthetase 0.0038 0.0417 1
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0006 0.0017 0.005
Plasmodium falciparum calcium-dependent protein kinase 5 0.0039 0.0427 0.0625
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2247 0.6501
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0006 0.0017 0.0013
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0038 0.0417 0.0538
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0295 0.4682
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0163 0.021
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0089
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0005 0.0007 0.0009
Plasmodium falciparum glutathione reductase 0.0044 0.05 0.0733
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0089
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0015 0.0128 0.0211
Trichomonas vaginalis helicase, putative 0.0007 0.0031 0.0089
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0815 0.105
Brugia malayi Sugar transporter family protein 0.0018 0.0163 0.021
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0006 0.0017 0.0022
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0126 0.1534 0.1527
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0163 0.0156
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0473 0.1368
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0005 0.0007 0.0009
Schistosoma mansoni sugar transporter 0.0018 0.0163 0.0273
Echinococcus multilocularis solute carrier family 22 0.0018 0.0163 0.0156
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0015 0.0128 0.0165
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0017 0.0017
Plasmodium falciparum hexose transporter 0.0126 0.1534 0.2276
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0427 0.042
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0427 0.1236
Schistosoma mansoni sugar transporter 0.0018 0.0163 0.0273
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0497 0.7983
Giardia lamblia Hexose transporter 0.0018 0.0163 0.346
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0039 0.0427 0.0944
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0005 0.0007 0.0009
Brugia malayi major facilitator superfamily protein 0.0018 0.0163 0.021
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0113 0.1362 1
Schistosoma mansoni GTP-binding protein alpha subunit 0.0006 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Trypanosoma brucei glucose transporter, putative 0.0039 0.0433 0.695
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0473 0.1368
Schistosoma mansoni glucose transport protein 0.0126 0.1534 0.2674
Onchocerca volvulus 0.0018 0.0163 0.0542
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0163 0.021
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0211 0.0455
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0007 0.0029 0.0326
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0017 0.0022
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0427 0.042
Plasmodium falciparum threonine--tRNA ligase 0.0007 0.0029 0.003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0373 0.0471
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0473 0.1365
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0473 0.0816
Onchocerca volvulus 0.0015 0.0128 0.0419
Trichomonas vaginalis sugar transport protein, putative 0.0018 0.0163 0.0472
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0133 0.0186
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0163 0.0472
Brugia malayi Serotonin receptor 0.0005 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0018 0.0053
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0039 0.0427 0.055
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0876 0.1129
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0006 0.0017 0.0013
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0017 0.0017
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0318 0.0311
Brugia malayi beta-lactamase family protein 0.0042 0.0473 0.0609
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0133 0.0281
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0015 0.0128 0.0155
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0101 0.1219 0.3603
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0007 0.0029 0.0475
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0473 0.7596
Leishmania major glucose transporter, lmgt1 0.0039 0.0433 0.695
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1534 0.1527
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0133 0.2039
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0433 0.695
Brugia malayi Serotonin receptor 0.0005 0.0007 0.0009
Mycobacterium tuberculosis Conserved protein 0.0042 0.0473 0.1365
Mycobacterium ulcerans beta-lactamase 0.0042 0.0473 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0133 0.1914
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0211 0.0301
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.176 0.1754
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0078 0.0091
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0473 0.0816
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0006 0.0017 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0163 0.0472
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.05 0.8008
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0433 0.1254
Echinococcus granulosus translational activator gcn1 0.0006 0.0009 0.0002
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0295 0.0645
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0433 0.1254
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0417 0.0719
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0078 0.0071
Toxoplasma gondii exonuclease III APE 0.0022 0.0218 0.0471
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0433 0.695
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0238 0.0689
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.05 0.0644
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Brugia malayi putative neuropeptide receptor NPR1 0.0005 0.0007 0.0009
Treponema pallidum NADH oxidase 0.0015 0.0133 0.5534
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0005 0.0007 0.0009
Leishmania major hypothetical protein, conserved 0.0018 0.0163 0.2527
Echinococcus granulosus muscleblind protein 0.0619 0.7762 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0473 0.1365
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Onchocerca volvulus 0.0018 0.0163 0.0542
Plasmodium falciparum protein kinase 7 0.0357 0.4444 0.6622
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0427 0.0542
Brugia malayi CXXC zinc finger family protein 0.0032 0.0344 0.0444
Echinococcus granulosus low density lipoprotein receptor protein 0.0015 0.0128 0.0155
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0278 0.3457 0.4454
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0039 0.0427 0.055
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0211 0.3303
Loa Loa (eye worm) hypothetical protein 0.0034 0.0373 0.048
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0006 0.0017 0.005
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0113 0.1362 0.4031
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0006 0.0017 0.0022
Echinococcus granulosus glycyl tRNA synthetase 0.0007 0.0029 0.0028
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0006 0.0017 0.0022
Trypanosoma brucei glucose transporter, putative 0.0039 0.0433 0.695
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Echinococcus multilocularis low density lipoprotein receptor protein 0.0015 0.0128 0.0121
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0006 0.0017 0.0017
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0295 0.0371
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0133 0.1914
Schistosoma mansoni hypothetical protein 0.0312 0.388 0.6784
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0473 0.7559
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0163 0.3187
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0473 0.0609
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0295 0.0504
Brugia malayi sulfakinin receptor protein 0.0005 0.0007 0.0009
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0433 0.695
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0218 0.4868
Trypanosoma brucei glucose transporter, putative 0.0039 0.0433 0.695
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0473 0.0609
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0031 0.0089
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Onchocerca volvulus Putative transporter 0.0018 0.0163 0.0542
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0006 0.0017 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0089
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0133 0.1914
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0006 0.0017 0.0022
Brugia malayi Calcium binding EGF domain containing protein 0.0015 0.0128 0.0165
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0218 0.0211
Schistosoma mansoni hypothetical protein 0.0024 0.0244 0.0415
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0089
Schistosoma mansoni hypothetical protein 0.0034 0.0373 0.064
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0163 0.3187
Onchocerca volvulus 0.0018 0.0163 0.0542
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0373 0.0366
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0022
Mycobacterium tuberculosis Probable oxidoreductase 0.0113 0.1362 0.4031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0089
Loa Loa (eye worm) hypothetical protein 0.0038 0.0417 0.0538
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165
Brugia malayi follicle stimulating hormone receptor 0.0005 0.0007 0.0009
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0497 0.7952
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0133 0.1914
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0018 0.0163 0.0231
Loa Loa (eye worm) hypothetical protein 0.0042 0.0473 0.0609
Brugia malayi Sugar transporter family protein 0.0126 0.1534 0.1976
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0211 0.0301
Schistosoma mansoni importin-beta 2 0.0006 0.0009 0.0003
Brugia malayi Muscleblind-like protein 0.0619 0.7762 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0039 0.0427 0.0625
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.176 0.3071
Loa Loa (eye worm) importin-beta domain-containing protein 0.0006 0.0009 0.0011
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Leishmania major hypothetical protein, conserved 0.0042 0.0473 0.7596
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0218 0.0272
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0042 0.0473 0.0609
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0133 0.2532
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0218 0.0599
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0078 0.0101
Plasmodium falciparum mitogen-activated protein kinase 2 0.0204 0.2516 0.3743
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0397 0.039
Echinococcus multilocularis thioredoxin glutathione reductase 0.0045 0.0507 0.0501
Echinococcus multilocularis solute carrier family 22 0.0018 0.0163 0.0156
Schistosoma mansoni glucose transporter 0.0018 0.0163 0.0273
Schistosoma mansoni GTP-binding protein alpha subunit 0.0006 0.0017 0.0017
Schistosoma mansoni glucose transport protein 0.0126 0.1534 0.2674
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2247 0.6501
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0015 0.0128 0.0155
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0815 0.1415
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0619 0.7762 1
Onchocerca volvulus 0.003 0.0318 0.108
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0006 0.0017 0.005
Mycobacterium ulcerans lipase LipD 0.0042 0.0473 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0473 0.0609
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0006 0.0017 0.0022
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0133 0.0186
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.0457 0.5715 1
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Brugia malayi Thioredoxin reductase 0.0044 0.05 0.0644
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Loa Loa (eye worm) hypothetical protein 0.0039 0.0427 0.055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0318 0.0545
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0218 0.3319
Plasmodium vivax calcium-dependent protein kinase, putative 0.0039 0.0427 0.0625
Onchocerca volvulus 0.0015 0.0128 0.0419
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0015 0.0128 0.0165
Trichomonas vaginalis ran, putative 0.0022 0.0211 0.0609
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0211 0.3198
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0318 0.0545
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0133 0.2039
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0133 0.5534
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0022
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0211 0.0271
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0089
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0133 0.2039
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0089
Brugia malayi G protein-coupled receptor 0.0005 0.0007 0.0009
Brugia malayi G-protein alpha subunit 0.0006 0.0017 0.0022
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0241 0.0669
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0113 0.1362 0.4031
Echinococcus multilocularis solute carrier family 22 0.0018 0.0163 0.0156
Brugia malayi Dopamine receptor protein 2 0.0005 0.0007 0.0009
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0163 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0089
Brugia malayi hypothetical protein 0.0018 0.0163 0.021
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165
Schistosoma mansoni sugar transporter 0.0018 0.0163 0.0273
Onchocerca volvulus 0.0042 0.0473 0.1617
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0244 0.0237
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0006 0.0017 0.001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.131 0.1687
Brugia malayi ORL1-like opioid receptor 0.0005 0.0007 0.0009
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0238 0.0689
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0053 0.0059
Plasmodium vivax sugar transporter, putative 0.0018 0.0163 0.0231
Trypanosoma brucei trypanothione reductase 0.0044 0.05 0.8039
Brugia malayi kap beta 3 protein 0.0006 0.0009 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0813 0.1411
Brugia malayi neuropeptide F receptor 0.0005 0.0007 0.0009
Loa Loa (eye worm) sugar transporter 0.0018 0.0163 0.021
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0295 0.0427
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Onchocerca volvulus 0.0018 0.0163 0.0542
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.0497 0.11
Leishmania major trypanothione reductase 0.0044 0.05 0.8039
Onchocerca volvulus 0.0018 0.0163 0.0542
Brugia malayi TAR-binding protein 0.0069 0.0815 0.105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0133 0.1914
Echinococcus granulosus low density lipoprotein receptor ldl 0.0015 0.0128 0.0155
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0209 0.3176
Plasmodium falciparum thioredoxin reductase 0.0044 0.05 0.0733
Loa Loa (eye worm) hypothetical protein 0.0054 0.062 0.0799
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0018 0.0163 0.0435
Echinococcus multilocularis translational activator gcn1 0.0006 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0101 0.1219 0.3603
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0006 0.0017 0.001
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0163 0.0273
Trypanosoma brucei glucose transporter 2A 0.0039 0.0433 0.695
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0006 0.0011 0.0006
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0128 0.0211
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0006 0.0017 0.0022
Plasmodium vivax SET domain protein, putative 0.003 0.0318 0.0462
Brugia malayi RNA binding protein 0.0069 0.0815 0.105
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0006 0.0017 0.005
Brugia malayi G-protein coupled receptor 0.0005 0.0007 0.0009
Schistosoma mansoni protein kinase 0.0039 0.0427 0.0736
Mycobacterium leprae Probable lipase LipE 0.0042 0.0473 0.3385
Loa Loa (eye worm) beta-lactamase 0.0042 0.0473 0.0609
Onchocerca volvulus 0.0018 0.0163 0.0542
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0473 0.7559
Onchocerca volvulus 0.0018 0.0163 0.0542
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0015 0.0133 0.0346
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0015 0.0128 0.0419
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0006 0.0017 0.0017
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0163 0.3187
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0018 0.0163 0.7108
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Entamoeba histolytica hypothetical protein 0.0028 0.0295 0.6837
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Onchocerca volvulus 0.0018 0.0163 0.0542
Echinococcus multilocularis geminin 0.0183 0.2256 0.225
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0133 0.0281
Echinococcus granulosus solute carrier family 22 0.0018 0.0163 0.0201
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0433 0.6902
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0038 0.0417 0.2971
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0005 0.0007 0.0009
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0218 0.0281
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0318 0.0311
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0053 0.0081
Echinococcus granulosus cpg binding protein 0.0034 0.0368 0.0465
Brugia malayi G-protein coupled receptor 0.0005 0.0007 0.0009
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0433 0.1254
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1534 0.1968
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0039 0.0427 0.0944
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.062 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Mycobacterium ulcerans sugar transporter 0.0018 0.0163 0.3187
Onchocerca volvulus 0.0015 0.0128 0.0419
Schistosoma mansoni hypothetical protein 0.0034 0.0373 0.064
Toxoplasma gondii sugar transporter ST1 0.0018 0.0163 0.0348
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0006 0.0017 0.001
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0015 0.0128 0.0165
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Onchocerca volvulus Glucosylceramidase homolog 0.0183 0.2247 0.778
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0006 0.0017 0.005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.176 0.2268
Loa Loa (eye worm) hypothetical protein 0.0029 0.0308 0.0397
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.062 0.0912
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0473 0.1365
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0039 0.0427 0.6848
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0473 0.1365
Plasmodium falciparum proline--tRNA ligase 0.0044 0.0497 0.0728
Entamoeba histolytica G protein alpha subunit, putative 0.0006 0.0017 0.0201
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0163 0.2409
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0163 0.0348
Loa Loa (eye worm) glutathione reductase 0.0044 0.05 0.0644
Leishmania major glucose transporter, lmgt2 0.0039 0.0433 0.695
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0038 0.0417 0.1207
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0007 0.0029 0.023
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0133 0.2039
Leishmania major hypothetical protein, conserved 0.0006 0.0018 0.0155
Onchocerca volvulus 0.0015 0.0128 0.0419
Brugia malayi hypothetical protein 0.0018 0.0163 0.021
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0344 0.0444
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0318 0.0698
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0427 0.0736
Onchocerca volvulus 0.0018 0.0163 0.0542
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0815 0.105
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0038 0.0417 0.041
Brugia malayi beta-lactamase 0.0042 0.0473 0.0609
Loa Loa (eye worm) melatonin receptor type 1A 0.0005 0.0007 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0005 0.0007 0.0009
Loa Loa (eye worm) neuropeptide F receptor 0.0005 0.0007 0.0009
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0015 0.0128 0.0121
Echinococcus multilocularis cpg binding protein 0.0034 0.0368 0.0361
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0006 0.0017 0.0013
Echinococcus granulosus thioredoxin glutathione reductase 0.0045 0.0507 0.0645
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0721 0.1606
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0218 0.0312
Leishmania major importin beta-1 subunit, putative 0.0024 0.0238 0.3756
Schistosoma mansoni ran 0.0022 0.0211 0.0356
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0082 0.0105
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0373 0.048
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.3457 1
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.3457 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0089
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0133 0.5534
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0163 0.0472
Leishmania major GTP-binding protein, putative 0.0022 0.0211 0.3303
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0101 0.1219 0.8937
Onchocerca volvulus 0.0018 0.0163 0.0542
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0218 0.063
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0133 0.0126
Plasmodium falciparum calcium-dependent protein kinase 1 0.0039 0.0427 0.0625
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0241 0.166
Echinococcus multilocularis GPCR, family 2 0.0034 0.0373 0.0366
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0473 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0163 0.0201
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0005 0.0007 0.0009
Loa Loa (eye worm) RNA binding protein 0.0069 0.0815 0.105
Loa Loa (eye worm) hypothetical protein 0.0108 0.131 0.1687
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0015 0.0128 0.0121
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0815 0.1415
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0007 0.0029 0.0031
Onchocerca volvulus 0.0015 0.0128 0.0419
Brugia malayi AKH receptor 0.0005 0.0007 0.0009
Loa Loa (eye worm) G-protein coupled receptor 0.0005 0.0007 0.0009
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0039 0.0427 0.0944
Loa Loa (eye worm) hypothetical protein 0.0028 0.0295 0.038
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0241 0.0669
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0308 0.0301
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Echinococcus granulosus dnaJ subfamily B 0.0457 0.5715 0.736
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0278 0.3457 0.4454
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1534 0.1968
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0308 0.0675
Schistosoma mansoni hypothetical protein 0.0183 0.2256 0.3939
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0473 0.0466
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0008 0.0039 0.0499
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0038 0.0417 0.0538
Toxoplasma gondii sugar transporter ST2 0.0018 0.0163 0.0348
Schistosoma mansoni cpg binding protein 0.0034 0.0368 0.0631
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0433 0.6902
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0006 0.0017 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.2372 0.686
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0218 0.3422
Brugia malayi CUB domain containing protein 0.0015 0.0128 0.0165
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0039 0.0427 0.055
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0163 0.0472
Toxoplasma gondii protein kinase, putative 0.0357 0.4444 1
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0006 0.0017 0.005
Loa Loa (eye worm) kap beta 3 protein 0.0006 0.0009 0.0011
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0133 0.2532
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0211 0.0204
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0015 0.0128 0.0121
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0815 0.1415
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0218 0.063
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1534 0.1527
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Onchocerca volvulus 0.0018 0.0163 0.0542
Trypanosoma brucei glucose transporter, putative 0.0039 0.0433 0.695
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.05 0.1446
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.388 0.4998
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0133 0.2532
Loa Loa (eye worm) hypothetical protein 0.0042 0.0473 0.0609
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0089
Schistosoma mansoni cpg binding protein 0.0032 0.0344 0.0591
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.062 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0427 0.042
Plasmodium falciparum glutathione reductase 0.0015 0.0133 0.0186
Echinococcus multilocularis snurportin 1 0.0312 0.388 0.3875
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1534 0.1968
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0017 0.0022
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0295 0.4598
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165

Activities

Activity type Activity value Assay description Source Reference
CC50 = 88.01 uM NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) ChEMBL. 18579783
EC50 (functional) = 36.8 nM MMV: Inhibition of Plasmodium falciparum 3D7 (EC50). ChEMBL. No reference
EC50 (functional) = 48 nM MMV: Inhibition of Plasmodium falciparum K1 (EC50). ChEMBL. No reference
EC50 (functional) = 0.669 uM NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (functional) = 2.734 uM NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
Growth Inhibition (functional) = 28.0754 % MMV: Measure of pLDH activity as indication of parasite viability. Gametocytogenesis of 3D7 Plasmodium falciparum strain was induced in vitro and asexual parasites were depleted with N-acetylglucosamine. Gametocytes were treated with dihydroartemisinin, epoxomicin, methylene blue, primaquine, puromycin or chloroquine in 96-well plates and the pLDH activity was evaluated using a modified Makler protocol. Mosquito infectivity was measured by the standard membrane feeding assay. ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) = 0.064 uM MMV: Modified 3H-Hyoxanthine uptake assay; RPMI 1640 (Invitrogen cat#23400-013) without Sodium Bicarbonate (NaHCO3). ChEMBL. No reference
IC50 (functional) = 0.125 uM MMV: 3H-Hyoxanthine uptake assay; RPMI 1640 (Invitrogen cat#11875-093) with Sodium Bicarbonate (NaHCO3) 2000 mg/mL. ChEMBL. No reference
IC50 (functional) = 0.13607263565063477 uM MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). ChEMBL. No reference
IC50 (functional) = 0.136072635650635 uM MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). ChEMBL. No reference
IC50 (functional) = 0.216911837458611 uM MMV: Inhibition of Trypanosoma brucei rhodesiense (STIB 900) (HAT in vitro). ChEMBL. No reference
IC50 = 0.3894052505493164 uM MMV: Cytotoxicity against human fibroblasts (MRC-5) cells. ChEMBL. No reference
IC50 (functional) > 0.5 uM MMV: Modified 3H-Hyoxanthine uptake assay; 1% O2, 5% CO2 in N2. ChEMBL. No reference
IC50 (functional) > 0.5 uM MMV: 3H-Hyoxanthine uptake assay; 5% O2, 5% CO2 in N2. ChEMBL. No reference
IC50 (functional) = 0.879536211490631 uM MMV: Inhibition of Trypanosoma brucei brucei (Squib 427) (HAT in vitro). ChEMBL. No reference
IC50 (functional) > 1 uM MMV: MAP2K Protein kinase inhibition assay using recombinant PfMAP2K, protein substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 0.5 mM DTT, 1 mM MgCl2, 0.5 mg/mL BSA, and 10 ug/ml MAP2 in a buffer of 50 mM HEPES (pH 7.0). 0.5 mg/mL histone III-S served as the substrate (13); 100 uM AMP-PNP, an ATP analog, was used as a control inhibitor. Incubation time was 4 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK1 Protein kinase inhibition assay using recombinant PfCDPK1, syntide 2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK6 Protein kinase inhibition assay using recombinant PfPK6, Myelin Basic Protein (MBP) substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1.5 uM ATP, 5 mM MnCl2, and 15 ug/ml PK6 in a buffer of 100 mM Tris-HCl (pH 7.5). 50 ug/mL MBP was provided as the substrate; 10 uM staurosporine was used as a control inhibitor. Incubation time was 3 hours and 40 minutes.The catalytic activity of each kinase was considered proportional to ATP consumed, as determined from measurements of residual [ATP] with the luciferase-based reagent Kinase-Glo (Promega) following incubation. Luminescence (proportional to residual [ATP]) was measured on the plate readers FLx800 (BioTek Instruments, Winooski, VT, USA) and MicroBeta2. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK4 Protein kinase inhibition assay using recombinant PfCDPK4, syntide2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK7 Protein kinase inhibition assay using recombinant PfPK7, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 2 mM DTT, 20 mM MgCl2, 2 mM MnCl2, 0.01% BSA, and 6 ug/ml PK7, in a buffer of 20 mM Tris-HCl (pH 7.5). The enzyme itself was the only substrate present (since autophosphorylation occurs); 100 uM 1NA-PP1 was used as a control inhibitor. Incubation time was 3 hours. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: ProRS recombinant Plasmodium falciparum Prolyl-tRNA-synthetase, assay with yeast tRNA, ATP, and proline and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: KRS recombinant Plasmodium falciparum Lysyl-tRNA-synthetase, assay with yeast tRNA, ATP, and lysine and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) = 3.0068132877349854 uM MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. ChEMBL. No reference
IC50 (functional) = 3.00681328773499 uM MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. ChEMBL. No reference
IC50 (functional) = 13.48 uM MMV: A total of 100ul of inoculum was added to each well (parasite/cell ratio, ~10:1; final volume, 200 ul). Six hours after inoculation, nonadherent parasites were removed, and 100 ul of complete DMEM (1% penicillin-streptomycin, 3% FBS) supplemented with inhibitors at different concentrations (2-fold serial dilutions starting from 30 uM) was added to all except the negative-control wells. Positive controls, consisting of pyrimethamine (PYR) and sulfadiazine (SDZ) (20-mg/ml stocks in DMSO), were tested at a 2mg/ml final concentration. Each test was performed in triplicate. ChEMBL. No reference
IC50 (functional) > 30 uM MMV: Primary screening was performed with each compound at a 30 uM final concentration and in triplicate in sealed 96-well polystyrene microtiter plates. Parasite inocula (100 ul) comprising 20000 parasites/ml were added to each well and grown at 37 degrees C in a humidified atmosphere of 5% CO2 for 72 h. Positive controls consisted of metronidazole at 1 mg/ml. The growth of E. histolytica trophozoites in each well was determined microscopically by measuring the diameters of the confluent cells in drug-containing wells relative to those in the nega- tive-control wells. ChEMBL. No reference
Inhibition (functional) = -2 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 1.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = -2 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 11.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = -0.509285024504123 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Male gamete exflagellation was recorded and analysed by automated microscopy after 20 min. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 2.81713132358803 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = 2.8171313235880318 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = 7.1235550548208 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 7.123555054820802 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 7.16791817370582 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Female gamete formation was recorded 24 hr later by automated microscopy detection of surface labelling of female gametes with a Cy3-conjugated antibody reactive to Pfs25. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 14.9 % MMV: Screen against Mtb, single point, replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 18.7 % MMV: Screen against Mtb, single point, non replicating, at 25uM ChEMBL. No reference
Inhibition (binding) = 35.9 % MMV: Deoxyhypusine hydroxylase activity assay. ChEMBL. No reference
Inhibition (functional) = 93.00145581 % MMV: NCI60 panel. Malaria Box compounds were tested for inhibition of the human Renal Cancer cell line ACHN ChEMBL. No reference
Inhibition (functional) = 96 % MMV: Inhibition of Plasmodium falciparum 3D7 at 5uM compound concentration. ChEMBL. No reference
IZ = 1 mm MMV: Selection for compounds that exhibit enhanced toxicity in combination with artemisinin. Assay utilized the disc diffusion method with the observance of a clear zone indicating inhibition of growth. Synthetic complete medium containing 3% glycerol as a carbon source (SCG) was used in each assay. 10 uL of each compound was added to a paper disc which was placed on SCG and SCG+Artemisinin (0.2 uM) plates seeded with 10e6 yeast cells (WC081 strain: Mat a, leu2 delta 0, lys2 delta 0, ura3 delta 0, his3 delta 1, pdr1 delta::HIS3, pdr3 delta::kanMX4, derived from BY4742, regulators of Multi-drug resistance transporters have been deleted to enhance toxicity of compounds). Plates were incubated at 30 degrees C for 5 days and clear zones were measured. Compounds that produced a larger clear zone in the presence of artemisinin was considered to have an additive interaction with artemisinin. Results are reported as diameter of clear zone on SCG+artemisinin plates - diameter of clear zone on SCG plates without artemisinin. ChEMBL. No reference
Ratio (functional) = 0.863013698630137 MMV: Compounds (1uM) were screened in a 72hr growth assay monitored by flow cytometry both in the presence and absence of supplemental isopentenyl pyrophosphate (IPP) 200uM. Compounds which fail to show anti-malarial activity when chemically rescued by IPP are therefore specific to the apicoplast. The values are expressed as the ratio of the corresponding activity with and without IPP, respectively. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 24 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 48 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 72 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma cruzi ChEMBL23
Plasmodium falciparum ChEMBL23 18579783
Homo sapiens ChEMBL23
Trypanosoma brucei gambiense
Leishmania infantum ChEMBL23
Toxoplasma gondii ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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