Detailed information for compound 1105823

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 426.507 | Formula: C27H26N2O3
  • H donors: 2 H acceptors: 3 LogP: 3.45 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@]4(O)Cc2c1nc1ccccc1c2)CC1CC1
  • InChi: 1S/C27H26N2O3/c30-20-8-7-17-12-21-27(31)13-18-11-16-3-1-2-4-19(16)28-23(18)25-26(27,22(17)24(20)32-25)9-10-29(21)14-15-5-6-15/h1-4,7-8,11,15,21,25,30-31H,5-6,9-10,12-14H2/t21-,25+,26+,27-/m1/s1
  • InChiKey: HTYCDZLDBAZXNO-NVSKSXHLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opioid receptor, mu 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, kappa 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, delta 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0004 0.0002
Schistosoma mansoni zinc finger protein 0.0039 0.004 0.0038
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.002 0.082
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0004 0.0002
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0044 0.0161
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0002 0.0007
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0016 0.0004 0.0002
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0044 0.0546
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0072 0.007
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0059 0.0073 0.2754
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0042 0.0045 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0004 0.0002
Plasmodium vivax acetyl-CoA synthetase, putative 0.0042 0.0045 0.1629
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0022 0.0077
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0085
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0004 0.0002
Brugia malayi Bromodomain containing protein 0.0033 0.0032 0.0121
Schistosoma mansoni lamin 0.0027 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0033 0.0031
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0004 0.001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0058 0.0216
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0072 0.0094 0.0352
Loa Loa (eye worm) hypothetical protein 0.003 0.0026 0.0094
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0052
Mycobacterium ulcerans beta-lactamase 0.0072 0.0094 0.0193
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0045 0.0087
Echinococcus multilocularis sex peptide receptor 0.0016 0.0004 0.0002
Schistosoma mansoni amine GPCR 0.0016 0.0004 0.0002
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0008 0.0124
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0041 0.0038
Onchocerca volvulus 0.0039 0.0041 0.0509
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0171 0.0252 1
Schistosoma mansoni hypothetical protein 0.0034 0.0033 0.0031
Echinococcus granulosus serotonin receptor 0.0016 0.0004 0.0002
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0008 0.0124
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0004 0.0002
Plasmodium vivax vivapain-3 0.0018 0.0007 0.0081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.017 0.0302
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0142 0.0205 0.0379
Leishmania major cathepsin L-like protease 0.013 0.0187 0.9086
Echinococcus granulosus g protein coupled receptor 0.0016 0.0004 0.0002
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0142 0.0205 0.0434
Echinococcus granulosus intermediate filament protein 0.0027 0.0022 0.0019
Schistosoma mansoni hypothetical protein 0.0288 0.0438 0.0435
Leishmania major acetyl-CoA synthetase, putative 0.0042 0.0045 0.2014
Brugia malayi jmjC domain containing protein 0.0038 0.004 0.0152
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0336 0.0516 0.1975
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0033 0.0398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0398
Loa Loa (eye worm) hypothetical protein 0.0072 0.0094 0.0352
Echinococcus granulosus cysteine protease 0.0018 0.0007 0.0004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0004 0.0001
Brugia malayi sulfakinin receptor protein 0.0016 0.0004 0.0017
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.004 0.0037
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0004 0.0002
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0004 0.0002
Echinococcus granulosus chromobox protein 1 0.0068 0.0087 0.0084
Echinococcus multilocularis neuropeptide receptor A26 0.0923 0.1452 0.145
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0094 0.0352
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0045 0.0087
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0094 0.0193
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0016 0.0004 0.0017
Echinococcus multilocularis peregrin 0.0033 0.0032 0.0029
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0054 0.2708
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0039 0.049
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0059 0.0073 0.2754
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0077 0.0075
Echinococcus multilocularis microtubule associated protein 2 0.6281 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0004 0.0002
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0042 0.0045 0.1629
Brugia malayi follicle stimulating hormone receptor 0.024 0.0361 0.1385
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.004 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0007 0.011
Brugia malayi AMP-binding enzyme family protein 0.0142 0.0205 0.0786
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0187 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0016 0.0004 0.0002
Echinococcus multilocularis lamin dm0 0.0027 0.0022 0.0019
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.0176 0.0173
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0045 0.0087
Onchocerca volvulus 0.0042 0.0045 0.0571
Brugia malayi hypothetical protein 0.0016 0.0004 0.0017
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0008 0.0154
Loa Loa (eye worm) hypothetical protein 0.0049 0.0056 0.0209
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0042 0.0045 0.2217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0033 0.0398
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0072 0.027
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0827 0.1298 0.1296
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0187 1
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0004 0.0002
Entamoeba histolytica hypothetical protein 0.0288 0.0438 1
Brugia malayi RNA binding protein 0.0062 0.0077 0.0296
Brugia malayi putative neuropeptide receptor 0.0016 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Plasmodium vivax vivapain-2 0.0034 0.0033 0.115
Echinococcus granulosus neuropeptide receptor A26 0.0923 0.1452 0.145
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0033 0.0615
Entamoeba histolytica hypothetical protein 0.0288 0.0438 1
Brugia malayi Bromodomain containing protein 0.0148 0.0215 0.0823
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0106 0.0148 0.056
Plasmodium vivax glutathione reductase, putative 0.0047 0.0054 0.199
Brugia malayi beta-lactamase family protein 0.0072 0.0094 0.0359
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0004 0.0002
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0077 0.0289
Echinococcus granulosus allatostatin A receptor 0.0016 0.0004 0.0002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0004 0.0001
Schistosoma mansoni peptidase Clp (S14 family) 0.0171 0.0252 0.025
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0084 0.179
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0004 0.0002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0092 0.0126 0.0123
Onchocerca volvulus 0.0034 0.0033 0.0406
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0045 0.0087
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0033 0.0128
Brugia malayi beta-lactamase family protein 0.0072 0.0094 0.0359
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.0187 1
Onchocerca volvulus 0.0027 0.0022 0.0243
Echinococcus multilocularis orexin receptor type 2 0.0016 0.0004 0.0002
Schistosoma mansoni hypothetical protein 0.0123 0.0176 0.0173
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0004 0.0002
Loa Loa (eye worm) beta-lactamase 0.0072 0.0094 0.0352
Brugia malayi Cathepsin L-like precursor 0.0034 0.0033 0.0128
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0058 0.0223
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0087 0.1146
Schistosoma mansoni cellular tumor antigen P53 0.031 0.0474 0.0471
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0054 0.0201
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0094 0.0193
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0044 0.0546
Echinococcus granulosus peptidase Clp S14 family 0.0112 0.0158 0.0156
Onchocerca volvulus 0.031 0.0474 0.6554
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0187 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0042 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0033 0.0398
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0142 0.0205 0.0434
Schistosoma mansoni neuropeptide receptor 0.0016 0.0004 0.0002
Echinococcus multilocularis neuropeptide s receptor 0.0923 0.1452 0.145
Echinococcus multilocularis tumor protein p63 0.212 0.3361 0.336
Entamoeba histolytica acyl-CoA synthetase, putative 0.0142 0.0205 0.4601
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0016 0.0004 0.0017
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.002 0.082
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0142 0.0205 0.0779
Loa Loa (eye worm) hypothetical protein 0.0084 0.0113 0.0426
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0077 0.0075
Plasmodium vivax SET domain protein, putative 0.0059 0.0072 0.2722
Leishmania major cathepsin L-like protease 0.013 0.0187 0.9086
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0016 0.0004 0.0002
Echinococcus granulosus g protein coupled receptor 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0431 0.0666 0.2548
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0033 0.0398
Brugia malayi cathepsin L-like precursor 0.0023 0.0015 0.0059
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0087 0.1146
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0045 0.0174
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0106 0.0148 0.5775
Schistosoma mansoni hypothetical protein 0.0041 0.0044 0.0041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0045 0.0087
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0004 0.0002
Schistosoma mansoni microtubule-associated protein tau 0.6281 1 1
Echinococcus multilocularis lamin 0.0027 0.0022 0.0019
Schistosoma mansoni hypothetical protein 0.0039 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0041 0.0038
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0004 0.0002
Onchocerca volvulus 0.0072 0.0094 0.1247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0398
Leishmania major 4-coumarate:coa ligase-like protein 0.0142 0.0205 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0004 0.0002
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0002
Brugia malayi hypothetical protein 0.0288 0.0438 0.1677
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0045 0.0087
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0007 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0022 0.0235
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0072 0.0094 0.0352
Echinococcus granulosus dro:myosuppressin receptor 0.0016 0.0004 0.0002
Echinococcus granulosus tumor protein p63 0.212 0.3361 0.336
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0024 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0004 0.0002
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0073 0.0148
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0004 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0045 0.0174
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0008 0.0124
Brugia malayi Pre-SET motif family protein 0.0409 0.0631 0.2417
Brugia malayi ORL1-like opioid receptor 0.0016 0.0004 0.0017
Leishmania major cathepsin L-like protease 0.0034 0.0033 0.1423
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0118 0.0167 0.0164
Echinococcus multilocularis G-protein coupled receptor, putative 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0033 0.0398
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0094 0.4882
Onchocerca volvulus 0.0027 0.0022 0.0243
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0084 0.0082
Brugia malayi neuropeptide F receptor 0.0016 0.0004 0.0017
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0073 0.0071
Toxoplasma gondii ABC1 family protein 0.0072 0.0094 0.3587
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0398
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0004 0.0002
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0024 0.0773
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0033 0.1566
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0004 0.0015
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Brugia malayi hypothetical protein 0.1649 0.261 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0151 0.0316
Brugia malayi Melatonin receptor type 1A 0.0016 0.0004 0.0017
Brugia malayi CHD4 protein 0.0015 0.0003 0.001
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0004 0.0002
Brugia malayi Cathepsin L-like precursor 0.0034 0.0033 0.0128
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0038 0.0714
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0015 0.0146
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0042 0.0045 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0004 0.0002
Schistosoma mansoni chromobox protein 0.0068 0.0087 0.0084
Brugia malayi hypothetical protein 0.0039 0.0041 0.0157
Loa Loa (eye worm) melatonin receptor type 1A 0.0016 0.0004 0.001
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0016 0.0004 0.0002
Brugia malayi hypothetical protein 0.0016 0.0004 0.0017
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0033 0.115
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0033 0.0121
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0077 0.0075
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2904 0.4613 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.0205 0.0779
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0038 0.1636
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0033 0.0031
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0042 0.0045 0.1629
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.01 0.0139 0.029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0004 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0126 0.0123
Onchocerca volvulus 0.0039 0.0041 0.0509
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0033 0.0615
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0032 0.0058
Brugia malayi hypothetical protein 0.0016 0.0004 0.0017
Schistosoma mansoni polycystin 1-related 0.0039 0.0041 0.0038
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0001
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0042 0.0045 0.0166
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0022 0.0077
Trypanosoma cruzi ISWI complex protein 0.003 0.0027 0.1211
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0126 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0398
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0003 0.0003
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0171 0.0252 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0151 0.0316
Schistosoma mansoni neuropeptide f receptor 76f 0.0016 0.0004 0.0002
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0171 0.0252 0.0482
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0045 0.0087
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0094 0.0193
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0042 0.0045 0.0087
Schistosoma mansoni bromodomain containing protein 0.0125 0.0178 0.0175
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0142 0.0205 0.0434
Entamoeba histolytica hypothetical protein 0.0288 0.0438 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0004 0.0002
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0038 0.1801
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0094 0.0136
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0142 0.0205 0.0434
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0106 0.0148 0.031
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0004 0.0002
Trypanosoma brucei trypanothione reductase 0.0047 0.0054 0.2708
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0077 0.0075
Echinococcus granulosus neuropeptide receptor 0.0016 0.0004 0.0002
Leishmania major cathepsin L-like protease 0.013 0.0187 0.9086
Brugia malayi AMP-binding enzyme family protein 0.0142 0.0205 0.0786
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0004 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0004 0.0002
Mycobacterium ulcerans acetyl-CoA synthetase 0.0042 0.0045 0.0087
Brugia malayi Pre-SET motif family protein 0.0059 0.0072 0.0277
Echinococcus multilocularis survival motor neuron protein 1 0.1649 0.261 0.2608
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0042 0.0045 0.0087
Mycobacterium tuberculosis Possible penicillin-binding protein 0.046 0.0713 0.1536
Mycobacterium ulcerans acyl-CoA synthetase 0.0142 0.0205 0.0434
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0004 0.0002
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0054 0.0052
Schistosoma mansoni biogenic amine receptor 0.0016 0.0004 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0142 0.0205 0.0434
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0016 0.0004 0.0017
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0042 0.0045 0.089
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0008 0.0025
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Echinococcus granulosus fmrfamide receptor 0.0016 0.0004 0.0002
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0119 0.0169 0.9008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0004 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0187 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0045 0.0087
Trypanosoma brucei ISWI complex protein 0.003 0.0027 0.1211
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0008 0.0124
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0073 0.0148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0187 1
Onchocerca volvulus 0.0023 0.0015 0.0154
Brugia malayi Dopamine receptor protein 2 0.0016 0.0004 0.0017
Leishmania major 4-coumarate:coa ligase-like protein 0.0142 0.0205 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.008 0.0107 0.0403
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0094 0.0359
Leishmania major trypanothione reductase 0.0047 0.0054 0.246
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.01 0.0139 0.029
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0022 0.0077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0094 0.0091
Echinococcus granulosus g protein coupled receptor 0.0016 0.0004 0.0002
Echinococcus multilocularis chromobox protein 1 0.0068 0.0087 0.0084
Brugia malayi G-protein coupled receptor 0.0016 0.0004 0.0017
Echinococcus multilocularis chromobox protein 1 0.0068 0.0087 0.0084
Onchocerca volvulus 0.0431 0.0666 0.9241
Echinococcus multilocularis dro:myosuppressin receptor 0.0016 0.0004 0.0002
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0001
Schistosoma mansoni lipoxygenase 0.0163 0.0238 0.0236
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0069 0.0066
Loa Loa (eye worm) runx1 0.0054 0.0065 0.0242
Echinococcus granulosus cathepsin L 0.0018 0.0007 0.0004
Schistosoma mansoni opsin-like receptor 0.0016 0.0004 0.0002
Brugia malayi Doublecortin family protein 0.0039 0.0041 0.0157
Toxoplasma gondii cathepsin CPL 0.0034 0.0033 0.115
Schistosoma mansoni alpha-1 adrenergic receptor 0.0016 0.0004 0.0002
Echinococcus granulosus peregrin 0.0033 0.0032 0.0029
Plasmodium falciparum acyl-CoA synthetase 0.0106 0.0148 0.5775
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0007 0.0004
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0007 0.011
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0004 0.0002
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0004 0.0002
Echinococcus multilocularis G protein coupled receptor 139 0.0016 0.0004 0.0002
Leishmania major hypothetical protein, conserved 0.003 0.0027 0.11
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0094 0.0091
Entamoeba histolytica cysteine protease, putative 0.0034 0.0033 0.0615
Echinococcus granulosus g-protein coupled receptor 0.0016 0.0004 0.0002
Leishmania major cathepsin L-like protease 0.0034 0.0033 0.1423
Echinococcus granulosus neuropeptide s receptor 0.0923 0.1452 0.145
Brugia malayi G protein-coupled receptor F59B2.13 0.0016 0.0004 0.0017
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0042 0.0045 0.2217
Mycobacterium ulcerans lipase LipD 0.0072 0.0094 0.0193
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0033 0.0398
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0008
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0007 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.007 0.009 0.0088
Mycobacterium tuberculosis Probable reductase 0.0108 0.0151 0.0316
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0004 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0142 0.0205 0.0434
Echinococcus multilocularis cysteine protease 0.0034 0.0033 0.0031
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.004 0.0037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.01 0.0139 0.029
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0045 0.0174
Loa Loa (eye worm) hypothetical protein 0.0072 0.0094 0.0352
Schistosoma mansoni hypothetical protein 0.0336 0.0516 0.0513
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.002 0.0602
Brugia malayi TAR-binding protein 0.0062 0.0077 0.0296
Schistosoma mansoni acetyl-CoA synthetase 0.0042 0.0045 0.0043
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.0361 0.1379
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Echinococcus granulosus 7TM GPCR rhodopsin 0.0016 0.0004 0.0002
Schistosoma mansoni opsin-like receptor 0.0016 0.0004 0.0002
Plasmodium falciparum cysteine proteinase falcipain 1 0.0018 0.0007 0.0081
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0038 0.1801
Brugia malayi intermediate filament protein 0.0027 0.0022 0.0084
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0033 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0004 0.0002
Brugia malayi Cathepsin L-like precursor 0.0034 0.0033 0.0128
Echinococcus multilocularis neuropeptide FF receptor 2 0.0016 0.0004 0.0002
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0038 0.0035
Echinococcus granulosus geminin 0.0334 0.0512 0.051
Brugia malayi Serotonin receptor 0.0016 0.0004 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0039 0.0482
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0016 0.0004 0.0002
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0016 0.0004 0.0002
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0001
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0042 0.0045 0.0166
Leishmania major acetyl-CoA synthetase, putative 0.0042 0.0045 0.2014
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.0187 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0171 0.0252 1
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0007 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0004 0.0002
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0038 0.0458
Toxoplasma gondii exonuclease III APE 0.0018 0.0008 0.0124
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0004 0.0002
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0118 0.0167 0.0164
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Schistosoma mansoni intermediate filament proteins 0.0027 0.0022 0.0019
Mycobacterium ulcerans TetR family transcriptional regulator 0.2904 0.4613 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0398
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0033 0.0406
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0092 0.0089
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2904 0.4613 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0008 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0045 0.0087
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0045 0.0174
Echinococcus granulosus fetal alzheimer antigen falz 0.0044 0.005 0.0047
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0038 0.1323
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0033 0.003
Echinococcus granulosus somatostatin receptor 0.0016 0.0004 0.0002
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.002 0.0602
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0042 0.0045 0.0043
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0033 0.115
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0171 0.0252 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0044 0.0554
Echinococcus multilocularis thyroid hormone receptor alpha 0.0133 0.0192 0.0189
Loa Loa (eye worm) glutathione reductase 0.0047 0.0054 0.0201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0187 1
Onchocerca volvulus 0.0465 0.0721 1
Schistosoma mansoni lozenge 0.0054 0.0065 0.0063
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0171 0.0252 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0398
Loa Loa (eye worm) hypothetical protein 0.0431 0.0666 0.2548
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0097 0.0094
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.002 0.082
Echinococcus multilocularis somatostatin receptor 0.0016 0.0004 0.0002
Plasmodium falciparum thioredoxin reductase 0.0047 0.0054 0.199
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0087 0.0326
Schistosoma mansoni hypothetical protein 0.0334 0.0512 0.051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0072 0.007
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0288 0.0438 0.0435
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0073 0.2753
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0171 0.0252 0.0961
Loa Loa (eye worm) hypothetical protein 0.0072 0.0094 0.0352
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2904 0.4613 1
Schistosoma mansoni survival motor neuron protein 0.0336 0.0516 0.0513
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0008 0.0169
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0073 0.0148
Echinococcus multilocularis musashi 0.0027 0.0022 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0398
Brugia malayi Cathepsin L-like precursor 0.0034 0.0033 0.0128
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0033 0.0121
Onchocerca volvulus Alhambra homolog 0.0028 0.0024 0.0275
Echinococcus granulosus peptide allatostatin:somatostatin 0.0016 0.0004 0.0002
Onchocerca volvulus 0.003 0.0026 0.0307
Loa Loa (eye worm) inositol-1 0.0037 0.0038 0.0137
Entamoeba histolytica acyl-CoA synthetase, putative 0.0142 0.0205 0.4601
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0142 0.0205 0.0434
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0008 0.0031
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0042 0.0039
Echinococcus granulosus neuropeptide FF receptor 2 0.0016 0.0004 0.0002
Trichomonas vaginalis antibiotic synthetase, putative 0.0042 0.0045 0.0563
Mycobacterium tuberculosis Conserved protein 0.0072 0.0094 0.0193
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0042 0.0045 0.0087
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0004 0.0002
Entamoeba histolytica acyl-coA synthetase, putative 0.0142 0.0205 0.4601
Mycobacterium tuberculosis Conserved protein 0.0072 0.0094 0.0193
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0033 0.003
Loa Loa (eye worm) fibroinase 0.0034 0.0033 0.0121
Onchocerca volvulus 0.0034 0.0033 0.0406
Loa Loa (eye worm) hypothetical protein 0.0039 0.0041 0.015
Onchocerca volvulus 0.0042 0.0045 0.0571
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0034 0.0033 0.012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Leishmania major cathepsin L-like protease 0.0034 0.0033 0.1423
Schistosoma mansoni ap endonuclease 0.0018 0.0008 0.0005
Echinococcus granulosus sex peptide receptor 0.0016 0.0004 0.0002
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0106 0.0148 0.031
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0033 0.0031
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0038 0.0458
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0042 0.0045 0.2014
Loa Loa (eye worm) hypothetical protein 0.1649 0.261 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0016 0.0004 0.0002
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0171 0.0252 0.0537
Echinococcus granulosus transcription factor Dp 1 0.0038 0.004 0.0037
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Echinococcus granulosus chromobox protein 1 0.0068 0.0087 0.0084
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0142 0.0205 0.0379
Plasmodium falciparum phd finger protein, putative 0.0028 0.0024 0.0773
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0004 0.001
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0024 0.0085
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0024 0.0773
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0042 0.0045 0.003
Brugia malayi larval opioid receptor 0.0016 0.0004 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0045 0.0087
Mycobacterium ulcerans transcriptional regulator 0.2904 0.4613 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0007 0.011
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0007 0.011
Echinococcus multilocularis serotonin receptor 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.005 0.0058 0.0216
Brugia malayi Bromodomain containing protein 0.0076 0.0099 0.0381
Schistosoma mansoni zinc finger protein 0.003 0.0027 0.0024
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0171 0.0252 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0033 0.003
Brugia malayi PHD-finger family protein 0.0049 0.0057 0.0219
Schistosoma mansoni biogenic amine receptor 0.0016 0.0004 0.0002
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0016 0.0004 0.0002
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0004 0.0015
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0004 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0028
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0094 0.3587
Mycobacterium tuberculosis Conserved protein 0.0072 0.0094 0.0193
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0033 0.1423
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0038 0.1323
Echinococcus multilocularis g-protein coupled receptor 0.0016 0.0004 0.0002
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0166 0.0628
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0016 0.0004 0.0002
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0033 0.0406
Brugia malayi hypothetical protein 0.0016 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.0069
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0171 0.0252 1
Schistosoma mansoni biogenic amine receptor 0.0016 0.0004 0.0002
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0092 0.0126 0.0476
Schistosoma mansoni lipoxygenase 0.0233 0.035 0.0347
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0004 0.0002
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0171 0.0252 0.0537
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0094 0.124
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0004 0.0002
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0042 0.0045 0.1629
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0004 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0028
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.0187 1
Brugia malayi hypothetical protein 0.0016 0.0004 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0187 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0008 0.0169
Echinococcus multilocularis peptidase Clp (S14 family) 0.0112 0.0158 0.0156
Echinococcus granulosus orexin receptor type 2 0.0016 0.0004 0.0002
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0044 0.005 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0398
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0004 0.0002
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0171 0.0252 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0034 0.0031
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0151 0.0316
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0084 0.0082
Echinococcus granulosus neuropeptide receptor 0.0016 0.0004 0.0002
Leishmania major 4-coumarate:coa ligase-like protein 0.0142 0.0205 1
Onchocerca volvulus 0.0042 0.0045 0.0571
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0084 0.0315
Brugia malayi beta-lactamase 0.0072 0.0094 0.0359
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0007 0.0027
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0016 0.0004 0.0002
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0084 0.4349
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0038 0.1801
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0094 0.4882
Echinococcus multilocularis cysteine protease 0.0034 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.0076 0.01 0.0375
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0042 0.0045 0.003
Trichomonas vaginalis set domain proteins, putative 0.0465 0.0721 1
Schistosoma mansoni myosin xvIII 0.0016 0.0004 0.0002
Echinococcus granulosus cathepsin l1 0.0034 0.0033 0.0031
Leishmania major hypothetical protein, conserved 0.0072 0.0094 0.4436
Schistosoma mansoni neuropeptide receptor 0.0016 0.0004 0.0002
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0005 0.0002
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0024 0.0022
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Loa Loa (eye worm) cysteine protease 0.0034 0.0033 0.0121
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0016 0.0004 0.0002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0033 0.0398
Schistosoma mansoni chromobox protein 0.0068 0.0087 0.0084
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0033 0.0398
Loa Loa (eye worm) hypothetical protein 0.0039 0.0041 0.015
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0004 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0094 0.124
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0094 0.0091
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0004 0.0002
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0042 0.0045 0.0087
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0004 0.001
Brugia malayi Cathepsin L-like precursor 0.0023 0.0015 0.0059
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0042 0.0045 0.003
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0042 0.0045 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0398
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Leishmania major cathepsin L-like protease 0.0034 0.0033 0.1423
Echinococcus granulosus tm gpcr rhodopsin 0.0641 0.1002 0.0999
Brugia malayi chromobox protein homolog 3 0.0038 0.0039 0.0151
Schistosoma mansoni hypothetical protein 0.0028 0.0024 0.0022
Mycobacterium leprae Probable lipase LipE 0.0072 0.0094 0.0136
Loa Loa (eye worm) hypothetical protein 0.0139 0.0201 0.0765
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0033 0.0398
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0094 0.124
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0033 0.0127
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0016 0.0004 0.0002
Echinococcus granulosus alpha 1A adrenergic receptor 0.0016 0.0004 0.0002
Brugia malayi hypothetical protein 0.0016 0.0004 0.0017
Brugia malayi RE15519p 0.0016 0.0004 0.0017
Schistosoma mansoni rab6-interacting 0.0039 0.0041 0.0038
Brugia malayi G protein-coupled receptor 0.0016 0.0004 0.0017
Echinococcus multilocularis RUN 0.0039 0.0041 0.0038
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0016 0.0004 0.001
Brugia malayi MH2 domain containing protein 0.0117 0.0166 0.0634
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0077 0.0296
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0033 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0187 1
Echinococcus granulosus tar DNA binding protein 0.0062 0.0077 0.0075
Onchocerca volvulus 0.0034 0.0033 0.0406
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0112 0.0158 0.0333
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0004 0.0002
Brugia malayi hypothetical protein 0.0016 0.0004 0.0017
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0084 0.0322
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0094 0.0193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0007 0.011
Echinococcus granulosus cathepsin l1 0.0023 0.0015 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.01 0.0139 0.029
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0094 0.4882
Entamoeba histolytica hypothetical protein 0.0288 0.0438 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0166 0.0628
Trypanosoma cruzi ISWI complex protein 0.003 0.0027 0.1211
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0041 0.0038
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.0176 0.0173
Schistosoma mansoni neuropeptide receptor 0.0016 0.0004 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0094 0.124
Echinococcus multilocularis zinc finger protein 0.0039 0.004 0.0038
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0016 0.0004 0.0002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0008 0.0005
Echinococcus granulosus 7tm_1 domain containing protein 0.0016 0.0004 0.0002
Schistosoma mansoni lamin 0.0027 0.0022 0.0019
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0015 0.0013
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0094 0.0193
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0024 0.0773
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0142 0.0205 0.0434
Brugia malayi AKH receptor 0.0016 0.0004 0.0017
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0042 0.0045 0.2217
Brugia malayi G-protein coupled receptor 0.0016 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0288 0.0438 0.0435
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0073 0.0071
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0004 0.0002
Echinococcus multilocularis allatostatin A receptor 0.0016 0.0004 0.0002
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0033 0.0406
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0112 0.0158 0.0333
Plasmodium falciparum glutathione reductase 0.0047 0.0054 0.199
Brugia malayi Cathepsin L-like precursor 0.0034 0.0033 0.0128
Plasmodium vivax vivapain-2 0.0034 0.0033 0.115
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0007 0.0027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0033 0.0398
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0042 0.0045 0.0174
Onchocerca volvulus 0.0042 0.0045 0.0571
Plasmodium vivax unspecified product 0.0018 0.0007 0.0081
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0094 0.0193
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0008 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0187 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Echinococcus multilocularis Protein lozenge 0.0054 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0016 0.0004 0.0002
Schistosoma mansoni opsin-like receptor 0.0016 0.0004 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0039 0.0482
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0094 0.0193
Loa Loa (eye worm) oxidoreductase 0.0042 0.0045 0.0166
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0084 0.4349
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0054 0.199
Brugia malayi Cathepsin L-like precursor 0.0023 0.0015 0.0059
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0039 0.0144
Onchocerca volvulus 0.0336 0.0516 0.7134
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0016 0.0004 0.001
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0127 0.0125
Brugia malayi jmjC domain containing protein 0.0093 0.0127 0.0487
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0004 0.0002
Brugia malayi hypothetical protein 0.0016 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0034 0.0033 0.0121
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0094 0.124
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0042 0.0045 0.2217
Trichomonas vaginalis esterase, putative 0.0072 0.0094 0.124
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0022 0.0084
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0041 0.1451
Trypanosoma cruzi cruzipain precursor, putative 0.013 0.0187 1
Toxoplasma gondii hypothetical protein 0.0059 0.0073 0.2754
Leishmania major hypothetical protein, conserved 0.0026 0.002 0.0745
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0015 0.0059
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0042 0.0045 0.0087
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0004 0.0002
Onchocerca volvulus 0.0142 0.0205 0.2802
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0094 0.0193
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.0003 0.0012
Brugia malayi Inositol-1 0.0037 0.0038 0.0145
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0042 0.0045 0.2217
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.004 0.0145
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0004 0.0002
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0004 0.0001
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0004 0.0002
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.017 0.0358
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0052
Echinococcus granulosus histone lysine methyltransferase setb 0.0092 0.0126 0.0123
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0058 0.0223
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0024 0.0022
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0036 0.0036 0.0067
Loa Loa (eye worm) hypothetical protein 0.0106 0.0148 0.056
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0008 0.0043
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0409 0.0631 0.2411
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0016 0.0004 0.0017
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0005 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0004 0.0002
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0042 0.0039
Echinococcus granulosus GPCR family 2 0.0016 0.0004 0.0001
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0042 0.0045 0.0087
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0008 0.0169
Brugia malayi Serotonin receptor 0.0016 0.0004 0.0017
Schistosoma mansoni rab6-interacting 0.0039 0.0041 0.0038
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0042 0.0045 0.0087
Schistosoma mansoni loxhd1 0.0039 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Schistosoma mansoni ap endonuclease 0.0018 0.0008 0.0005
Schistosoma mansoni inositol monophosphatase 0.0037 0.0038 0.0035
Loa Loa (eye worm) TYRA-2 protein 0.0016 0.0004 0.001
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0004 0.0002
Schistosoma mansoni thyroid hormone receptor 0.0133 0.0192 0.0189
Echinococcus granulosus zinc finger protein 0.0039 0.004 0.0038
Brugia malayi hypothetical protein 0.0039 0.0041 0.0157
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0016 0.0004 0.0017
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0004 0.001
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0054 0.0052
Brugia malayi Heterochromatin protein 1 0.0068 0.0087 0.0333
Brugia malayi glutathione reductase 0.0047 0.0054 0.0208
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0033 0.0398
Toxoplasma gondii thioredoxin reductase 0.0047 0.0054 0.199
Mycobacterium ulcerans hypothetical protein 0.0142 0.0205 0.0434
Echinococcus granulosus lamin dm0 0.0027 0.0022 0.0019
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0084 0.3952
Schistosoma mansoni adenoreceptor 0.0016 0.0004 0.0002
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0233 0.035 0.0347
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0045 0.0087
Onchocerca volvulus 0.0034 0.0033 0.0406
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0005 0.0019
Loa Loa (eye worm) hypothetical protein 0.0142 0.0205 0.0779
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0005 0.0002
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.017 0.0358
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0041 0.015
Echinococcus multilocularis geminin 0.0334 0.0512 0.051
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0233 0.035 0.0347
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0073 0.0071
Onchocerca volvulus 0.0034 0.0033 0.0406
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0004 0.0002
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.017 0.0358
Echinococcus granulosus hypothetical protein 0.0016 0.0004 0.0002
Onchocerca volvulus 0.007 0.009 0.1196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0187 1
Schistosoma mansoni thyroid hormone receptor 0.0133 0.0192 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0073
Schistosoma mansoni hypothetical protein 0.0334 0.0512 0.051
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.004 0.0037
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0059 0.0073 0.0091
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0033 0.0031
Onchocerca volvulus 0.0072 0.0094 0.1247
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0038 0.0458
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0084 0.0082
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0127 0.0125
Schistosoma mansoni amine GPCR 0.0016 0.0004 0.0002
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0042 0.0045 0.0087
Mycobacterium ulcerans hypothetical protein 0.0072 0.0094 0.0193
Loa Loa (eye worm) ctsf protein 0.0034 0.0033 0.0121
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0041 0.1451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0015 0.0146
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0038 0.0071
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0077 0.0075
Onchocerca volvulus 0.0034 0.0033 0.0406
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0042 0.0045 0.0087
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0016 0.0004 0.0002
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0002
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0033 0.115
Echinococcus multilocularis GPCR, family 2 0.0016 0.0004 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0004 0.0002
Brugia malayi hypothetical protein 0.0026 0.002 0.0076
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0042 0.0045 0.0087
Brugia malayi Thioredoxin reductase 0.0047 0.0054 0.0208
Schistosoma mansoni neuropeptide receptor 0.0016 0.0004 0.0002
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0084 0.4349
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0059 0.0073 0.2754
Brugia malayi Tachykinin-like peptides receptor 99D 0.0016 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Schistosoma mansoni histamine h1 receptor 0.0016 0.0004 0.0002
Brugia malayi hypothetical protein 0.0431 0.0666 0.2553
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0001
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0171 0.0252 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0398
Echinococcus granulosus lamin 0.0027 0.0022 0.0019
Onchocerca volvulus 0.0034 0.0033 0.0406
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0151 0.0316
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0016 0.0004 0.0002
Brugia malayi hypothetical protein 0.0017 0.0005 0.002
Brugia malayi AMP-binding enzyme family protein 0.0142 0.0205 0.0786
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0016 0.0004 0.0002
Loa Loa (eye worm) RNA binding protein 0.0062 0.0077 0.0289
Trypanosoma cruzi major cysteine proteinase, putative 0.0102 0.0142 0.7552
Brugia malayi Cathepsin L-like precursor 0.0034 0.0033 0.0128
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0073 0.0071
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0008 0.1609
Toxoplasma gondii propionate-CoA ligase 0.0042 0.0045 0.1629
Brugia malayi Dopamine receptor protein 1 0.0016 0.0004 0.0017
Brugia malayi Probable ClpP-like protease 0.0171 0.0252 0.0967
Loa Loa (eye worm) hypothetical protein 0.0072 0.0094 0.0352
Brugia malayi hypothetical protein 0.0016 0.0004 0.0017
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0072 0.2722
Schistosoma mansoni amine GPCR 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0052
Loa Loa (eye worm) hypothetical protein 0.0106 0.0148 0.056
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0034 0.0125
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0002
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0151 0.026
Schistosoma mansoni hypothetical protein 0.003 0.0027 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0398
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0042 0.0045 0.0087
Schistosoma mansoni transcription factor LCR-F1 0.0288 0.0438 0.0435
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0171 0.0252 0.025
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0073 0.3405
Plasmodium vivax acyl-CoA synthetase, putative 0.0106 0.0148 0.5775
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0004 0.0002
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0041 0.0038
Brugia malayi GnHR receptor homolog 0.0016 0.0004 0.0017
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0004 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0022 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0398
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0004 0.0002
Brugia malayi hypothetical protein 0.0016 0.0004 0.0017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0073 0.0148
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0106 0.0148 0.056
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0004 0.0002
Giardia lamblia PHD finger protein 15 0.0028 0.0024 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0041 0.0038
Schistosoma mansoni amine GPCR 0.0016 0.0004 0.0002
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0112 0.0158 0.0276
Trichomonas vaginalis antibiotic synthetase, putative 0.0042 0.0045 0.0563
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0166
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0007 0.0004
Brugia malayi Dopamine receptor 0.0016 0.0004 0.0017
Echinococcus granulosus survival motor neuron protein 1 0.1649 0.261 0.2608
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0016 0.0004 0.001
Schistosoma mansoni inositol monophosphatase 0.0037 0.0038 0.0035
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0045 0.0174
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0016 0.0004 0.0002
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0054 0.0107
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0092 0.0089
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0042 0.0045 0.0087
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.002 0.0602
Echinococcus granulosus G protein coupled receptor 139 0.0016 0.0004 0.0002
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0033 0.003
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0166
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0077 0.0075
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0094 0.0193
Loa Loa (eye worm) hypothetical protein 0.0106 0.0148 0.056
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0042 0.0045 0.2217
Echinococcus granulosus RUN 0.0039 0.0041 0.0038
Brugia malayi putative neuropeptide receptor NPR1 0.0016 0.0004 0.0017
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0016 0.0004 0.001
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.031 0.0474 0.181
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0045 0.0087
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0044 0.005 0.0047
Brugia malayi PHD-finger family protein 0.0028 0.0024 0.0092
Echinococcus multilocularis cathepsin L 0.0018 0.0007 0.0004
Brugia malayi neuropeptide F receptor 0.0016 0.0004 0.0017
Echinococcus multilocularis serotonin receptor 0.0016 0.0004 0.0002
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0077 0.0289
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0015 0.0196
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0641 0.1002 0.0999
Onchocerca volvulus 0.0072 0.0094 0.1247
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0007 0.011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0187 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.002 0.0602
Schistosoma mansoni amine GPCR 0.0016 0.0004 0.0002
Leishmania major cathepsin L-like protease 0.0034 0.0033 0.1423
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0016 0.0004 0.0002
Plasmodium vivax vivapain-1 0.0018 0.0007 0.0081
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0004 0.0002
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0151 0.0316
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0094 0.0091
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0033 0.0031

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 9.78 nM Inverse agonist activity at human DOR expressed in CHO cell membranes by [35S]GTPgammaS binding assay ChEMBL. 26048798
Emax (binding) = 32.4 % Inverse agonist activity at human DOR expressed in CHO cell membranes by [35S]GTPgammaS binding assay relative to control ChEMBL. 26048798
IC50 ratio (functional) = 7.5 Competitive inhibition of Ethylketazocine on Guinea pig ileal longitudinal muscle for the opioid receptor kappa at 100 nM ChEMBL. 1851846
IC50 ratio (functional) = 9.9 Competitive inhibition of Morphine on Guinea pig ileal longitudinal muscle for the opioid receptor mu at 100 nM ChEMBL. 1851846
IC50 ratio (functional) = 54 Competitive inhibition of the DADLE on mouse vas deferens for the opioid receptor delta at 100 nM ChEMBL. 1851846
Ke (functional) = 1.9 Antagonistic potency at opioid receptor delta (100 nM) (Ke =IC50 in the presence of antagonist divided by the control IC50 value) ChEMBL. 1851846
Ke (functional) = 11 Antagonistic potency at opioid receptor mu (100 nM) (Ke =IC50 in the presence of antagonist divided by the control IC50 value) ChEMBL. 1851846
Ke (functional) = 15.4 Antagonistic potency at opioid receptor kappa (100 nM) (Ke =IC50 in the presence of antagonist divided by the control IC50 value) ChEMBL. 1851846
Ki (binding) = 0.407 nM Displacement of [3H]DPDPE from human DOR expressed in CHO cells ChEMBL. 26048798
Ki (binding) = 11 nM Displacement of [3H]U-69,593 from human KOR expressed in CHO cells ChEMBL. 26048798
Ki (binding) = 20.8 nM Displacement of [3H]DAMGO from human MOR expressed in CHO cells ChEMBL. 26048798
Ratio (binding) = 6 Selectivity ratio is IC50 value of mu-opioid receptor to that of delta-opioid receptor ChEMBL. 1851846
Ratio (binding) = 8 Selectivity ratio is IC50 value of opioid receptor kappa to that of opioid receptor delta ChEMBL. 1851846

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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