Detailed information for compound 1108277

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 371.175 | Formula: C14H12Cl2N4O4
  • H donors: 3 H acceptors: 6 LogP: 1.04 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1OC([C@@H]([C@@H]1O)O)n1cnc2c1nc1cc(Cl)c(cc1n2)Cl
  • InChi: 1S/C14H12Cl2N4O4/c15-5-1-7-8(2-6(5)16)19-13-12(18-7)17-4-20(13)14-11(23)10(22)9(3-21)24-14/h1-2,4,9-11,14,21-23H,3H2/t9-,10-,11-,14?/m1/s1
  • InChiKey: WCDLKFDMGMUZSG-POGOCJABSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0017 0.0024 0.011
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0015 0.0752
Loa Loa (eye worm) hypothetical protein 0.0074 0.0195 0.0895
Brugia malayi hypothetical protein 0.0132 0.0369 0.1697
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0163 0.7939
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0024 0.0022
Brugia malayi calpain 7 0.0021 0.0036 0.0167
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.011 0.0304 0.3266
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0036 0.1773
Brugia malayi Cathepsin L-like precursor 0.0017 0.0024 0.011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0024 0.0155
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0139 0.0139
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0269 0.0314
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0024 0.0155
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0274 0.0274
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0055 0.0139 0.127
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0063 0.0164 0.0191
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0024 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0163 0.7939
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0069 0.0181 0.0387
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0139 0.0162
Loa Loa (eye worm) hypothetical protein 0.0074 0.0195 0.0895
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0037 0.1119
Giardia lamblia Pyruvate kinase 0.0017 0.0027 0.0195
Loa Loa (eye worm) hypothetical protein 0.0069 0.0182 0.0836
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0139 0.0901
Schistosoma mansoni phd/f-box containing protein 0.0063 0.0164 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0001 0.0003
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0271 0.0316
Onchocerca volvulus 0.0026 0.0051 0.0327
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0195 0.9471
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0205 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0339 0.0776
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0024 0.0155
Trypanosoma brucei unspecified product 0.0014 0.0017 0.0847
Onchocerca volvulus Huntingtin homolog 0.0132 0.0369 0.2386
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0319 0.0931 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.007
Loa Loa (eye worm) hypothetical protein 0.0055 0.0139 0.0638
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0172 0.0201
Toxoplasma gondii thioredoxin reductase 0.0048 0.0118 0.104
Onchocerca volvulus 0.0099 0.0271 0.175
Plasmodium falciparum acyl-CoA synthetase 0.0055 0.0139 0.1498
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.015 0.0423 0.1946
Echinococcus multilocularis muscleblind protein 0.0487 0.1432 0.1432
Onchocerca volvulus Huntingtin homolog 0.0132 0.0369 0.2386
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0159 0.7567
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0126 0.0578
Echinococcus granulosus survival motor neuron protein 1 0.0735 0.2175 0.2538
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0032
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.0402 0.0469
Loa Loa (eye worm) hypothetical protein 0.0049 0.0121 0.0552
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0024 0.1185
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0076 0.0487
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0001 0.0001
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0118 0.127
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0195 0.0443
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0039 0.0037
Schistosoma mansoni hypothetical protein 0.0041 0.0098 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0037 0.1787
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.0195 0.632
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0039 0.0169
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0139 0.0139
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0209 0.0601 0.1392
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.0205 0.1329
Schistosoma mansoni jumonji domain containing protein 0.0237 0.0685 0.0799
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0037 0.0237
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0195 0.0443
Leishmania major DNA polymerase eta, putative 0.0021 0.0037 0.1119
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0045 0.0053
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) oxidoreductase 0.0022 0.0039 0.0178
Schistosoma mansoni hypothetical protein 0.0699 0.2068 0.2413
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0024 0.0261
Loa Loa (eye worm) inositol-1 0.0077 0.0205 0.0941
Echinococcus multilocularis dna polymerase eta 0.0021 0.0037 0.0037
Brugia malayi nuclear hormone receptor 0.0009 0.0001 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0024 0.0155
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0015 0.0752
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0024 0.0776
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0037 0.1787
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0163 0.7939
Mycobacterium ulcerans TetR family transcriptional regulator 0.1371 0.4077 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0369 0.1694
Loa Loa (eye worm) hypothetical protein 0.0024 0.0045 0.0205
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0024 0.0468
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0039 0.1273
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0039 0.0169
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0024 0.0028
Leishmania major hypothetical protein, conserved 0.0063 0.0164 0.7824
Echinococcus multilocularis pyruvate kinase 0.0034 0.0076 0.0076
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0015 0.0068
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0045 0.0292
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0037 0.1787
Loa Loa (eye worm) hypothetical protein 0.0043 0.0103 0.047
Brugia malayi steroid hormone receptor 0.0009 0.0001 0.0003
Entamoeba histolytica protein kinase, putative 0.0021 0.0039 0.1256
Brugia malayi MAP kinase sur-1 0.0055 0.0139 0.064
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0045 0.1811
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0036 0.1104
Loa Loa (eye worm) hypothetical protein 0.0051 0.0126 0.0578
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0036 0.1773
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0118 0.0541
Echinococcus granulosus muscleblind protein 0.0487 0.1432 0.1671
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0195 0.0422
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0036 0.1104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0024 0.0155
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.0302 0.0686
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0149 0.0328
Loa Loa (eye worm) hypothetical protein 0.0487 0.1432 0.6584
Brugia malayi Calcitonin receptor-like protein seb-1 0.0207 0.0593 0.2725
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0045 0.0053
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.0309 0.036
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0147 0.7142
Loa Loa (eye worm) glutathione reductase 0.0048 0.0118 0.0541
Echinococcus multilocularis lysine specific demethylase 5A 0.0237 0.0685 0.0685
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0039 0.1258
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0103 0.0103
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0024 0.1185
Echinococcus granulosus calpain 5 0.0021 0.0036 0.0042
Brugia malayi Cathepsin L-like precursor 0.0011 0.0008 0.0035
Echinococcus multilocularis lamin 0.0029 0.006 0.006
Trypanosoma brucei trypanothione reductase 0.0048 0.0118 0.576
Loa Loa (eye worm) hypothetical protein 0.01 0.0274 0.1256
Loa Loa (eye worm) hypothetical protein 0.0053 0.0132 0.0603
Schistosoma mansoni jumonji/arid domain-containing protein 0.0237 0.0685 0.0799
Echinococcus multilocularis musashi 0.0029 0.006 0.006
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0024 0.1185
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0039 0.0037
Echinococcus granulosus pyruvate kinase 0.0017 0.0027 0.0031
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0319 0.0931 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0059 0.0268
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0024 0.1185
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0039 0.1258
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0045 0.1464
Loa Loa (eye worm) hypothetical protein 0.0063 0.0164 0.0751
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1371 0.4077 1
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0036 0.0042
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1371 0.4077 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0269 0.0314
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0024 0.0022
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.0195 0.0443
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0103 0.012
Loa Loa (eye worm) hypothetical protein 0.0065 0.017 0.078
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0339 0.0776
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0076 0.0346
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0039 0.1258
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0001 0.0001
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0077 0.0205 0.6645
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0163 0.7939
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0037 0.1787
Leishmania major cathepsin L-like protease 0.0017 0.0024 0.045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.013 0.0262
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.0172 0.0172
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0039 0.1916
Echinococcus multilocularis pyruvate kinase 0.0027 0.0055 0.0055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0037 0.1787
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0024 0.0155
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0039 0.0178
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0032
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0024 0.0024
Loa Loa (eye worm) CAMK/CAMKL/PASK protein kinase 0.0045 0.011 0.0503
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0032
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0008 0.0247
Brugia malayi jmjC domain containing protein 0.0237 0.0685 0.3149
Trypanosoma brucei unspecified product 0.0014 0.0017 0.0847
Schistosoma mansoni DNA polymerase eta 0.0021 0.0037 0.0043
Echinococcus granulosus neuropeptide receptor A26 0.0468 0.1374 0.1603
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0163 0.7939
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0039 0.0059
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0076 0.0573
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0037 0.1787
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0195 0.9471
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0024 0.0022
Brugia malayi Cathepsin L-like precursor 0.0017 0.0024 0.011
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0149 0.0174
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0147 0.0147
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0024 0.0151
Echinococcus multilocularis neuropeptide receptor A26 0.0468 0.1374 0.1374
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0024 0.0028
Schistosoma mansoni hypothetical protein 0.015 0.0423 0.0494
Echinococcus multilocularis geminin 0.0699 0.2068 0.2068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0024 0.0155
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0036 0.1773
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.017 0.017
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0039 0.0059
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0008 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0039 0.0181
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0001 0.0001
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0024 0.0776
Echinococcus multilocularis cysteine protease 0.0017 0.0024 0.0024
Echinococcus granulosus cathepsin l1 0.0017 0.0024 0.0028
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0037 0.0043
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0149 0.0328
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0139 0.6781
Plasmodium vivax glutathione reductase, putative 0.0048 0.0118 0.127
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0099 0.0271 0.1243
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.011 0.0304 0.3266
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0036 0.1104
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0024 0.1185
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0015 0.0068
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0045 0.0045
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0039 0.1916
Echinococcus granulosus geminin 0.0699 0.2068 0.2413
Plasmodium vivax JmjC domain containing protein 0.0063 0.0164 0.1762
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0319 0.0931 0.2207
Echinococcus multilocularis tumor protein p63 0.0676 0.1999 0.1999
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.0302 0.0686
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0001 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0039 0.0059
Plasmodium falciparum JmjC domain-containing protein, putative 0.0063 0.0164 0.1762
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0024 0.045
Echinococcus multilocularis hypothetical protein 0.0021 0.0036 0.0036
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0139 0.0901
Echinococcus granulosus lamin 0.0029 0.006 0.007
Echinococcus multilocularis jumonji domain containing 1A 0.0063 0.0164 0.0164
Schistosoma mansoni hypothetical protein 0.0699 0.2068 0.2413
Echinococcus multilocularis phd:f box containing protein 0.0063 0.0164 0.0164
Echinococcus multilocularis protein dispatched 1 0.0049 0.0121 0.0121
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0073 0.0193 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0001 0.0003
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0024 0.1168
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0024 0.0024
Echinococcus granulosus pyruvate kinase 0.0034 0.0076 0.0089
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0039 0.0039
Echinococcus granulosus lamin dm0 0.0029 0.006 0.007
Schistosoma mansoni survival motor neuron protein 0.015 0.0423 0.0494
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0024 0.0028
Schistosoma mansoni microtubule-associated protein tau 0.2871 0.8569 1
Brugia malayi Thioredoxin reductase 0.0048 0.0118 0.0544
Echinococcus granulosus lysine specific demethylase 5A 0.0237 0.0685 0.0799
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0027 0.0285
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0163 0.7939
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0159 0.149
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0039 0.1916
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0001 0.0003
Trypanosoma brucei antigen, putative 0.0021 0.0036 0.1773
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0036 0.1773
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0001 0.0001
Plasmodium falciparum pyruvate kinase 0.0034 0.0076 0.0816
Echinococcus multilocularis peptidase Clp (S14 family) 0.0209 0.0601 0.0601
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0024 0.0261
Schistosoma mansoni pyruvate kinase 0.0034 0.0076 0.0089
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0103 0.012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0024 0.0155
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0039 0.0181
Onchocerca volvulus 0.0022 0.0039 0.0251
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0024 0.0151
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0063 0.0164 0.1544
Schistosoma mansoni peptidase Clp (S14 family) 0.0319 0.0931 0.1086
Leishmania major DNA polymerase kappa, putative 0.0021 0.0037 0.1119
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0139 0.0637
Loa Loa (eye worm) hypothetical protein 0.0029 0.006 0.0275
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0461 0.1354 0.6225
Mycobacterium tuberculosis Probable reductase 0.011 0.0302 0.0686
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0339 0.0776
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0341 0.1566
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0001 0.0003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0269 0.0314
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0126 0.0147
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0024 0.1185
Brugia malayi cathepsin L-like precursor 0.0011 0.0008 0.0035
Leishmania major trypanothione reductase 0.0048 0.0118 0.5416
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0024 0.0028
Schistosoma mansoni hypothetical protein 0.0041 0.0098 0.0115
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0147 0.0172
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0159 0.0159
Schistosoma mansoni patched 1 0.0043 0.0103 0.012
Brugia malayi ecdysteroid receptor 0.0009 0.0001 0.0003
Echinococcus granulosus pyruvate kinase 0.0034 0.0076 0.0089
Giardia lamblia DINP protein human, muc B family 0.0021 0.0037 0.1075
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0036 0.1773
Echinococcus multilocularis GPCR, family 2 0.0065 0.017 0.017
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0149 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0001 0.0003
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0037 0.0037
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0037 0.1787
Echinococcus granulosus JmjC domain containing protein 4 0.0063 0.0164 0.0191
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0036 0.1773
Leishmania major cathepsin L-like protease 0.0017 0.0024 0.045
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0039 0.0181
Entamoeba histolytica cysteine protease, putative 0.0017 0.0024 0.0776
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0037 0.0052
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0036 0.1773
Onchocerca volvulus 0.0017 0.0024 0.0151
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0037 0.0166
Onchocerca volvulus 0.0022 0.0039 0.0251
Schistosoma mansoni coup transcription factor 0.0009 0.0001 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0139 0.0901
Echinococcus granulosus neuropeptide s receptor 0.0468 0.1374 0.1603
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0024 0.011
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0024 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0037 0.1787
Echinococcus granulosus pyruvate kinase 0.0017 0.0027 0.0031
Echinococcus multilocularis JmjC domain containing protein 4 0.0063 0.0164 0.0164
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0005 0.0024
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0063 0.0164 0.7988
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0001 0.0001
Mycobacterium ulcerans transcriptional regulator 0.1371 0.4077 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0172 0.0201
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0039 0.0037
Leishmania major cathepsin L-like protease 0.0063 0.0163 0.7771
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0024 0.0468
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0159 0.0186
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.0165 0.0193
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0037 0.1787
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0269 0.0269
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0024 0.0155
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0045 0.0053
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0001 0.0001
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0139 0.127
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0024 0.0155
Echinococcus multilocularis lysine specific demethylase 6a 0.0063 0.0164 0.0164
Brugia malayi CHE-14 protein 0.0043 0.0103 0.0473
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0205 1
Echinococcus multilocularis protein patched 0.0043 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0487 0.1432 0.6584
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0039 0.0059
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.0036 0.1773
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0163 0.7939
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0302 0.0686
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0001 0.0001
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0147 0.0172
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0024 0.1185
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0037 0.003
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0118 0.0118
Brugia malayi Probable ClpP-like protease 0.0319 0.0931 0.4279
Echinococcus multilocularis pyruvate kinase 0.0017 0.0027 0.0027
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0076 0.3698
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0069 0.0181 0.0351
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.0402 0.0402
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0039 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0001 0.0003
Echinococcus granulosus microtubule associated protein 2 0.2871 0.8569 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0037 0.1187
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0076 0.0346
Loa Loa (eye worm) CYP4Cod1 0.0014 0.0015 0.0068
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.013 0.0262
Schistosoma mansoni hypothetical protein 0.0041 0.0098 0.0115
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0077 0.0205 0.1999
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0319 0.0931 0.2253
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.0302 0.0686
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0001 0.0001
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0147 0.0147
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0039 0.0059
Loa Loa (eye worm) hypothetical protein 0.0069 0.0182 0.0836
Schistosoma mansoni hypothetical protein 0.0065 0.017 0.0199
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0319 0.0931 0.1086
Loa Loa (eye worm) MBCTL1 0.0058 0.0147 0.0675
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0063 0.0164 0.0191
Schistosoma mansoni calpain (C02 family) 0.0021 0.0036 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0024 0.0155
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0269 0.1233
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0195 0.0897
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0037 0.0043
Loa Loa (eye worm) hypothetical protein 0.0141 0.0397 0.1824
Brugia malayi MH2 domain containing protein 0.0122 0.0341 0.1568
Echinococcus granulosus tumor protein p63 0.0676 0.1999 0.2333
Echinococcus multilocularis survival motor neuron protein 1 0.0735 0.2175 0.2175
Entamoeba histolytica hypothetical protein 0.0112 0.0309 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0024 0.0261
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0045 0.2198
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.017 0.017
Plasmodium falciparum thioredoxin reductase 0.0017 0.0024 0.0261
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0163 0.7939
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0001 0.0003
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0209 0.0601 0.1423
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0195 0.632
Loa Loa (eye worm) hypothetical protein 0.0055 0.0139 0.0638
Onchocerca volvulus 0.015 0.0423 0.2738
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0319 0.0931 0.4277
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0073 0.0193 0.0225
Echinococcus multilocularis calpain 5 0.0021 0.0036 0.0036
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0278 0.0325
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0039 0.1916
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0118 0.576
Echinococcus granulosus jumonji domain containing 1A 0.0063 0.0164 0.0191
Mycobacterium ulcerans hypothetical protein 0.0074 0.0195 0.0443
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0039 0.0181
Giardia lamblia Pyruvate kinase 0.0034 0.0076 0.4491
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.006 0.0275
Trypanosoma cruzi kinesin, putative 0.0021 0.0036 0.1773
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0045 0.0205
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0164 0.0751
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0126 0.0814
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0039 0.0422
Brugia malayi calpain family protein 1 0.0069 0.0182 0.0839
Schistosoma mansoni lamin 0.0029 0.006 0.007
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0011 0.0051
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0195 0.0443
Loa Loa (eye worm) hypothetical protein 0.0055 0.0139 0.0638
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0172 0.1637
Brugia malayi jmjC domain containing protein 0.0063 0.0164 0.0754
Onchocerca volvulus 0.0029 0.006 0.0387
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0163 0.7939
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0139 0.6781
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0024 0.0155
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0037 0.0169
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0118 0.0232
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0039 0.0059
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0016 0.0019
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0237 0.0685 0.0799
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0055 0.0139 0.0284
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0039 0.0181
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0036 0.1773
Brugia malayi jmjC domain containing protein 0.0063 0.0164 0.0754
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0149 0.0684
Loa Loa (eye worm) hypothetical protein 0.0058 0.0147 0.0675
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0163 0.7939
Loa Loa (eye worm) hypothetical protein 0.0055 0.0139 0.0638
Loa Loa (eye worm) hypothetical protein 0.0132 0.0369 0.1694
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0039 0.0255
Leishmania major pyruvate kinase 0.0034 0.0076 0.3186
Schistosoma mansoni pyruvate kinase 0.0034 0.0076 0.0089
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0024 0.1185
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0164 0.0191
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0274 0.1258
Toxoplasma gondii hypothetical protein 0.011 0.0304 0.3088
Echinococcus granulosus calpain A 0.0021 0.0036 0.0042
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0319 0.0931 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0269 0.0314
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0001 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0269 0.0314
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0076 0.0149
Brugia malayi jmjC domain containing protein 0.0237 0.0685 0.3149
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0319 0.0931 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0159 0.0332
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0039 0.0037
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0024 0.0004
Onchocerca volvulus 0.0011 0.0008 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0024 0.0155
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.0397 0.1826
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0024 0.1185
Loa Loa (eye worm) cysteine protease 0.0017 0.0024 0.0107
Echinococcus multilocularis neuropeptide s receptor 0.0468 0.1374 0.1374
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0001 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0037 0.1787
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.0195 0.0422
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0037 0.1787
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0147 0.0678
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0045 0.0485
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0195 0.0897
Onchocerca volvulus 0.0017 0.0024 0.0151
Schistosoma mansoni lamin 0.0029 0.006 0.007
Brugia malayi Cytochrome P450 family protein 0.0014 0.0015 0.0071
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0126 0.0147
Chlamydia trachomatis pyruvate kinase 0.0034 0.0076 0.0569
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0024 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0024 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0001 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0269 0.0269
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.0309 0.0309
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0172 0.0201
Entamoeba histolytica hypothetical protein 0.0112 0.0309 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0024 0.0258
Brugia malayi intermediate filament protein 0.0029 0.006 0.0278
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0024 0.0028
Onchocerca volvulus 0.0017 0.0024 0.0151
Echinococcus multilocularis pyruvate kinase 0.0017 0.0027 0.0027
Brugia malayi glutathione reductase 0.0048 0.0118 0.0544
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0076 0.0091
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0076 0.0349
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0139 0.6781
Loa Loa (eye worm) ctsf protein 0.0017 0.0024 0.0107
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0024 0.0157
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0001 0.0003
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0076 0.0491
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0027 0.0029
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0139 0.6519
Schistosoma mansoni calpain C (C02 family) 0.0021 0.0036 0.0042
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0063 0.0164 0.7988
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.017 0.078
Echinococcus granulosus intermediate filament protein 0.0029 0.006 0.007
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0137 0.0628
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0037 0.1787
Echinococcus granulosus calpain A 0.0073 0.0193 0.0225
Onchocerca volvulus 0.0051 0.0126 0.0814
Echinococcus granulosus lysine specific demethylase 6a 0.0063 0.0164 0.0191
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0274 0.8862
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0076 0.3698
Entamoeba histolytica calpain large subunit domain III containing protein 0.0021 0.0036 0.1178
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0126 0.0126
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0036 0.1773
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.0172 0.0201
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0195 0.0443
Brugia malayi Cytochrome P450 family protein 0.0014 0.0015 0.0071
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0195 0.0443
Echinococcus granulosus pyruvate kinase 0.0017 0.0027 0.0031
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0039 0.0255
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0107
Onchocerca volvulus 0.0029 0.006 0.0387
Brugia malayi Pre-SET motif family protein 0.0461 0.1354 0.6226
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.0139 0.0305
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0037 0.003
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0037 0.0043
Leishmania major cathepsin L-like protease 0.0017 0.0024 0.045
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0001 0.0001
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0319 0.0931 0.2253
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0001 0.0001
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0126 0.0147
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0139 0.6519
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0076 0.3698
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0024 0.0261
Brugia malayi mbt repeat family protein 0.0051 0.0126 0.0581
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0163 0.7939
Echinococcus multilocularis calpain A 0.0073 0.0193 0.0193
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0195 0.632
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0016 0.0016
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0037 0.0169
Schistosoma mansoni inositol monophosphatase 0.0077 0.0205 0.024
Schistosoma mansoni hypothetical protein 0.0065 0.017 0.0199
Onchocerca volvulus 0.0022 0.0039 0.0251
Schistosoma mansoni hypothetical protein 0.0065 0.017 0.0199
Echinococcus granulosus dna polymerase eta 0.0021 0.0037 0.0043
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.011 0.0304 0.0655
Echinococcus granulosus calpain 0.0021 0.0036 0.0042
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0039 0.0059
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0036 0.1773
Onchocerca volvulus 0.0525 0.1545 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0024 0.1185
Loa Loa (eye worm) hypothetical protein 0.0063 0.0164 0.0751
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0024 0.0468
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0195 0.0386
Brugia malayi Cathepsin L-like precursor 0.0017 0.0024 0.011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0159 0.0354
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0001 0.0001
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0045 0.0053
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0036 0.1773
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0039 0.0059
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.006 0.0278
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0024 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0103 0.0666
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0139 0.0162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0163 0.7939
Loa Loa (eye worm) hypothetical protein 0.0049 0.0121 0.0552
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0036 0.1773
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0001 0.0003
Echinococcus granulosus inositol monophosphatase 1 0.0077 0.0205 0.024
Echinococcus multilocularis calpain family protein 1, d 0.0049 0.0121 0.0121
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0126 0.0147
Trypanosoma brucei unspecified product 0.0021 0.0037 0.1787
Leishmania major cathepsin L-like protease 0.0017 0.0024 0.045
Brugia malayi hypothetical protein 0.0735 0.2175 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0001 0.0001
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0045 0.0233
Echinococcus multilocularis calpain 7 (C02 family) 0.0021 0.0036 0.0036
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0076 0.0349
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0045 0.1461
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0001 0.0001
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0036 0.1773
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0205 1
Plasmodium falciparum glutathione reductase 0.0017 0.0024 0.0261
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0163 0.7939
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0159 0.0186
Brugia malayi Cathepsin L-like precursor 0.0017 0.0024 0.011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0024 0.1185
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0207 0.0593 0.2725
Plasmodium falciparum thioredoxin reductase 0.0048 0.0118 0.127
Brugia malayi Latrophilin receptor protein 2 0.0065 0.017 0.0782
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0076 0.0346
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0024 0.0024
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0045 0.2198
Schistosoma mansoni jumonji/arid domain-containing protein 0.0237 0.0685 0.0799
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0063 0.0164 0.7988
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0001 0.0001
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0195 0.0386
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0037 0.1787
Brugia malayi Inositol-1 0.0077 0.0205 0.0944
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0045 0.0485
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0139 0.0162
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0319 0.0931 1
Echinococcus granulosus dna polymerase kappa 0.0021 0.0037 0.0043
Trichomonas vaginalis chaperonin, putative 0.0024 0.0045 0.0292
Schistosoma mansoni inositol monophosphatase 0.0077 0.0205 0.024
Loa Loa (eye worm) hypothetical protein 0.0207 0.0593 0.2723
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0045 0.0207
Brugia malayi Cathepsin L-like precursor 0.0011 0.0008 0.0035
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0063
Echinococcus multilocularis muscleblind protein 1 0.0487 0.1432 0.1432
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0159 0.0186
Echinococcus granulosus phd:f box containing protein 0.0063 0.0164 0.0191
Leishmania major cathepsin L-like protease 0.0017 0.0024 0.045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0008 0.0049
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0039 0.0059
Loa Loa (eye worm) hypothetical protein 0.0074 0.0195 0.0895
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0163 0.7939
Schistosoma mansoni hypothetical protein 0.0141 0.0397 0.0463
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0024 0.0155
Onchocerca volvulus 0.0017 0.0024 0.0151
Echinococcus granulosus peptidase Clp S14 family 0.0209 0.0601 0.0702
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0024 0.0155
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0195 0.0897
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0036 0.0042
Loa Loa (eye worm) hypothetical protein 0.0022 0.0039 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0024 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0024 0.0155
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0024 0.0155
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0205 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0037 0.0037
Loa Loa (eye worm) intermediate filament protein 0.0029 0.006 0.0275
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0027 0.0285
Echinococcus multilocularis inositol monophosphatase 1 0.0077 0.0205 0.0205
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0001 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0139 0.0901
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0039 0.1916
Onchocerca volvulus 0.0017 0.0024 0.0151
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.0302 0.0651
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0024 0.0258
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0024 0.0107
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0274 0.0319
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0024 0.0155
Loa Loa (eye worm) jmjC domain-containing protein 0.0237 0.0685 0.3147
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0237 0.0685 0.0685
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0172 0.0172
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0118 0.0138
Echinococcus granulosus cathepsin l1 0.0011 0.0008 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0037 0.1787
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0024 0.0024
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.003 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0024 0.0155
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0147 0.0172
Onchocerca volvulus 0.0074 0.0195 0.126
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0139 1
Leishmania major kinesin, putative 0.0021 0.0036 0.1104
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1371 0.4077 1
Schistosoma mansoni pyruvate kinase 0.0017 0.0027 0.0031
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0123 0.5974
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0076 0.0487
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0008 0.0035
Schistosoma mansoni phosphatidylserine receptor 0.0063 0.0164 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0037 0.1787
Entamoeba histolytica hypothetical protein 0.0112 0.0309 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0037 0.1787
Loa Loa (eye worm) hypothetical protein 0.0066 0.0172 0.079
Plasmodium vivax SET domain protein, putative 0.0066 0.0172 0.1853
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0024 0.0155
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0024 0.0157
Plasmodium vivax vivapain-2 0.0017 0.0024 0.0258
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0039 0.0059
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0149 0.703
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0001 0.0001
Echinococcus granulosus endonuclease exonuclease phosphatase 0.02 0.0573 0.0669
Loa Loa (eye worm) hypothetical protein 0.0022 0.0039 0.0178
Brugia malayi Cytochrome P450 family protein 0.0023 0.0042 0.0194
Echinococcus multilocularis pyruvate kinase 0.0034 0.0076 0.0076
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.013 0.0262
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0039 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.0041 0.0098 0.0115
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0039 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0024 0.0155
Brugia malayi hypothetical protein 0.0112 0.0309 0.142
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.017 0.0199
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0207 0.0593 0.2723
Schistosoma mansoni intermediate filament proteins 0.0029 0.006 0.007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.013 0.0262
Loa Loa (eye worm) hypothetical protein 0.0735 0.2175 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0001 0.0001
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0021 0.0094
Trichomonas vaginalis inositol monophosphatase, putative 0.0077 0.0205 0.1329
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0039 0.0059
Trypanosoma brucei cytochrome P450, putative 0.0014 0.0015 0.0752
Brugia malayi calpain 5 0.0021 0.0036 0.0167
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0039 0.0059
Schistosoma mansoni hypothetical protein 0.0065 0.017 0.0199
Echinococcus multilocularis microtubule associated protein 2 0.2871 0.8569 0.8569
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0319 0.0931 1
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0024 0.0151
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0017 0.0847
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0159 0.0354
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0209 0.0601 0.1423
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0319 0.0931 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0149 0.0149
Schistosoma mansoni hypothetical protein 0.0308 0.0898 0.1048
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0159 0.0354
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0139 0.6781
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0164 0.0751
Plasmodium vivax acyl-CoA synthetase, putative 0.0055 0.0139 0.1498
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0001 0.0003
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0063 0.0164 0.0164
Loa Loa (eye worm) calpain family protein 1 0.0049 0.0121 0.0552
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0341 0.1566
Trypanosoma cruzi kinesin, putative 0.0021 0.0036 0.1773
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0076 0.3698
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0037 0.1787
Echinococcus multilocularis lamin dm0 0.0029 0.006 0.006
Schistosoma mansoni hypothetical protein 0.0112 0.0309 0.036
Echinococcus multilocularis calpain 0.0021 0.0036 0.0036
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0039 0.0059
Brugia malayi nuclear receptor NHR-88 0.0009 0.0001 0.0003
Loa Loa (eye worm) calpain 5 0.0021 0.0036 0.0164
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0039 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0039 0.0059
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0039 0.0059
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0077 0.0205 0.0467
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0139 0.6781
Leishmania major cathepsin L-like protease 0.0063 0.0163 0.7771
Echinococcus multilocularis cysteine protease 0.0017 0.0024 0.0024
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0045 0.1564
Plasmodium vivax vivapain-2 0.0017 0.0024 0.0258
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0037 0.1787
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0339 0.0742
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0126 0.0147
Loa Loa (eye worm) fibroinase 0.0017 0.0024 0.0107
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0319 0.0931 0.0931
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0001 0.0001
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.0302 0.0686
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0149 0.0307
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0001 0.0001
Trypanosoma brucei protein kinase, putative 0.0055 0.0139 0.6781
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0024 0.0024
Onchocerca volvulus 0.0066 0.0172 0.1112
Onchocerca volvulus 0.0017 0.0024 0.0151
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0039 0.1916
Onchocerca volvulus 0.0049 0.0121 0.0777
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0039 0.0037
Loa Loa (eye worm) calpain 0.0021 0.0036 0.0164
Echinococcus granulosus GPCR family 2 0.0065 0.017 0.0199
Echinococcus granulosus calpain 7 C02 family 0.0021 0.0036 0.0042
Leishmania major cathepsin L-like protease 0.0063 0.0163 0.7771
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0024 0.0468
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0077 0.0205 0.1996
Echinococcus multilocularis pyruvate kinase 0.0017 0.0027 0.0027
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0039 0.0046
Brugia malayi jmjC domain containing protein 0.0063 0.0164 0.0754
Loa Loa (eye worm) hypothetical protein 0.0063 0.0164 0.0751
Echinococcus granulosus expressed conserved protein 0.0094 0.0256 0.0298
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0039 0.0037
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.011 0.0304 0.3085
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0011 0.0051
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0037 0.0052
Plasmodium vivax calpain, putative 0.0021 0.0036 0.0391
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.017 0.0782
Loa Loa (eye worm) hypothetical protein 0.0034 0.0076 0.0346
Onchocerca volvulus 0.0017 0.0024 0.0151
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0021 0.0091
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0166
Echinococcus multilocularis expressed conserved protein 0.0094 0.0256 0.0256
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0269 0.1236
Brugia malayi Pre-SET motif family protein 0.0066 0.0172 0.0793
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0076 0.0127
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0036 0.0042
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0195 0.9471
Brugia malayi jmjC domain containing protein 0.0063 0.0164 0.0754
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0319 0.0931 1
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0076 0.0487
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0103 0.047
Onchocerca volvulus 0.0045 0.011 0.0708
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0042 0.0191
Trichomonas vaginalis set domain proteins, putative 0.0525 0.1545 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0039 0.0422
Loa Loa (eye worm) hypothetical protein 0.0055 0.0139 0.0638
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0024 0.1185
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0036 0.1773
Loa Loa (eye worm) calpain family protein 1 0.0069 0.0182 0.0836
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0069 0.0182 0.0213
Brugia malayi Cathepsin L-like precursor 0.0017 0.0024 0.011
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0076 0.0816
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0076 0.0491
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0024 0.0155
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0001 0.0001
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0024 0.0112
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0001 0.0003
Trypanosoma brucei kinesin, putative 0.0021 0.0036 0.1773
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0073 0.0193 0.0225
Entamoeba histolytica hypothetical protein 0.0112 0.0309 1
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0045 0.0205
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0039 0.0037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0172 0.0201
Brugia malayi calpain family protein 1 0.0069 0.0182 0.0839
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0045 0.0207
Plasmodium falciparum glutathione reductase 0.0048 0.0118 0.127
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0001 0.0001
Brugia malayi Muscleblind-like protein 0.0487 0.1432 0.6585
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0039 0.0059
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.0195 0.0443
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0017 0.0847
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.0309 0.036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0163 0.7939
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0024 0.0155
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0037 0.0237
Brugia malayi mbt repeat family protein 0.0051 0.0126 0.0581
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0164 0.0751
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.017 0.0199
Schistosoma mansoni protein phosphatase 2C 0.0063 0.0164 0.0191
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0039 0.0178
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.0205 0.1329
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.02 0.0573 0.0573
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0039 0.0181
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0063 0.0164 0.1544
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0039 0.0059
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0039 0.0046
Leishmania major pyruvate kinase 0.0034 0.0076 0.3186
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0037 0.1787
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0008 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0017 0.0847
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0024 0.1185
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0073 0.0193 0.0193
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0001 0.0003
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0021 0.0036 0.1773
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0039 0.0169

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 32 uM Antiviral activity against towne strain HCMV was determined by plaque reduction assay in duplicate wells using HFF cells ChEMBL. 10882370
IC50 (functional) = 45 uM Visual cytotoxicity against stationary human foreskin fibroblasts (HFF) cells at the time of HCMV plaque enumeration ChEMBL. 10882370

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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