TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 344.453 | Formula: C22H24N4
H donors: 1 H acceptors: 2 LogP: 5.23 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCc1nc2c(n1Cc1ccccc1)c1ccccc1nc2N
InChi: 1S/C22H24N4/c1-2-3-5-14-19-25-20-21(26(19)15-16-10-6-4-7-11-16)17-12-8-9-13-18(17)24-22(20)23/h4,6-13H,2-3,5,14-15H2,1H3,(H2,23,24)
InChiKey: FKPYLOWKLOKNKU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	toll-like receptor 7	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.003	0.0061	0.0061
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0196	0.2109	0.2082
Toxoplasma gondii	alpha tubulin TUBA1	0.063	0.7445	0.7437
Loa Loa (eye worm)	alpha-tubulin	0.063	0.7445	0.7445
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0136	0.137	0.137
Trichomonas vaginalis	tubulin alpha chain, putative	0.0256	0.2841	0.2797
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0147	0.0147
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0099	0.0914	0.0914
Loa Loa (eye worm)	thyroid receptor interactor	0.0037	0.0147	0.0147
Echinococcus granulosus	endophilin A3	0.0037	0.0147	0.0147
Leishmania major	beta tubulin	0.0837	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0837	1	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0065	0.0065
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Schistosoma mansoni	cell polarity protein	0.0037	0.0147	0.0147
Echinococcus granulosus	Tubulin beta 2C chain	0.0837	1	1
Trichomonas vaginalis	neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative	0.0037	0.0147	0.0086
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0094	0.0094
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0256	0.2841	0.2797
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Brugia malayi	MH2 domain containing protein	0.0368	0.422	0.422
Echinococcus multilocularis	epidermal growth factor receptor	0.003	0.0061	0.0061
Trichomonas vaginalis	p67phox protein, putative	0.0037	0.0147	0.0086
Entamoeba histolytica	hypothetical protein	0.0037	0.0147	0.0086
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0461	0.536	0.536
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0037	0.0147	0.0147
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0094	0.0169
Trypanosoma cruzi	alpha tubulin, putative	0.063	0.7445	0.7437
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Giardia lamblia	Beta tubulin	0.0837	1	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0129	0.1284	0.1284
Echinococcus granulosus	tubulin alpha chain	0.063	0.7445	0.7445
Loa Loa (eye worm)	hypothetical protein	0.0434	0.5028	0.5028
Brugia malayi	Variant SH3 domain containing protein	0.0037	0.0147	0.0147
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.0037	0.0147	0.0147
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.003	0.0061	0.0061
Brugia malayi	SH2 domain containing protein	0.0099	0.0914	0.0914
Schistosoma mansoni	tensin-related	0.0099	0.0914	0.0914
Echinococcus multilocularis	tubulin alpha chain	0.063	0.7445	0.7445
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0874	0.0874
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	TK/FER protein kinase	0.003	0.0061	0.0061
Echinococcus multilocularis	beta tubulin	0.0837	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.1284	0.1284
Brugia malayi	Spectrin alpha chain	0.0037	0.0147	0.0147
Trypanosoma brucei	epsilon tubulin	0.0452	0.5259	0.5243
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0099	0.0914	0.0914
Echinococcus granulosus	ephrin type A receptor 4 A	0.003	0.0061	0.0061
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0374	0.4295	0.4295
Trypanosoma cruzi	epsilon tubulin, putative	0.0452	0.5259	0.5243
Leishmania major	beta tubulin	0.0837	1	1
Echinococcus multilocularis	pyruvate kinase	0.0026	0.0009	0.0009
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0136	0.137	0.137
Onchocerca volvulus		0.003	0.0061	0.0054
Echinococcus granulosus	tubulin alpha chain	0.063	0.7445	0.7445
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Brugia malayi	integrin-linked kinase	0.003	0.0061	0.0061
Schistosoma mansoni	formin binding protein and related proteins	0.0037	0.0147	0.0147
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0147	0.0114
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0461	0.536	0.536
Echinococcus multilocularis	tyrosine protein kinase	0.003	0.0061	0.0061
Echinococcus granulosus	protein kinase	0.003	0.0061	0.0061
Trichomonas vaginalis	tubulin, putative	0.0837	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.063	0.7445	0.7445
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.003	0.0061	0.0028
Entamoeba histolytica	protein kinase, putative	0.0324	0.3682	0.3643
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.003	0.0061	0.0061
Echinococcus multilocularis	c src tyrosine kinase	0.0166	0.174	0.174
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0094	0.0032
Onchocerca volvulus		0.0129	0.1284	0.4428
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0423	0.4905	0.4905
Leishmania major	beta tubulin	0.0837	1	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.003	0.0061	0.0061
Schistosoma mansoni	microtubule-associated protein tau	0.0675	0.8004	0.8004
Onchocerca volvulus		0.003	0.0061	0.0054
Echinococcus granulosus	pyruvate kinase	0.0033	0.0094	0.0094
Onchocerca volvulus		0.003	0.0061	0.0054
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Onchocerca volvulus		0.0037	0.0147	0.0361
Schistosoma mansoni	tubulin subunit alpha	0.063	0.7445	0.7445
Loa Loa (eye worm)	SH2 domain-containing protein	0.0099	0.0914	0.0914
Brugia malayi	Furin-like cysteine rich region family protein	0.003	0.0061	0.0061
Echinococcus multilocularis	tyrosine kinase	0.003	0.0061	0.0061
Echinococcus multilocularis		0.0099	0.0914	0.0914
Schistosoma mansoni	hypothetical protein	0.003	0.0061	0.0061
Onchocerca volvulus		0.003	0.0061	0.0054
Echinococcus granulosus	Tubulin beta 2C chain	0.0837	1	1
Echinococcus multilocularis	transfer RNA-Ala	0.0037	0.0147	0.0147
Schistosoma mansoni	tubulin subunit alpha	0.063	0.7445	0.7445
Loa Loa (eye worm)	tubulin alpha 2	0.0434	0.5028	0.5028
Echinococcus multilocularis	Tubulin beta 2C chain	0.0837	1	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.003	0.0061	0.0061
Echinococcus multilocularis	tubulin alpha chain	0.063	0.7445	0.7445
Brugia malayi	SH2 domain containing protein	0.0099	0.0914	0.0914
Echinococcus multilocularis	endophilin A3	0.0037	0.0147	0.0147
Onchocerca volvulus		0.0099	0.0914	0.3104
Brugia malayi	beta-tubulin, identical	0.0837	1	1
Giardia lamblia	Delta tubulin	0.0196	0.2109	0.206
Echinococcus granulosus	tubulin beta 1 chain	0.0837	1	1
Echinococcus multilocularis	tubulin alpha chain	0.063	0.7445	0.7445
Entamoeba histolytica	hypothetical protein	0.0037	0.0147	0.0086
Plasmodium vivax	tubulin gamma chain, putative	0.0452	0.5259	0.5243
Trypanosoma brucei	beta tubulin	0.0837	1	1
Onchocerca volvulus		0.0099	0.0914	0.3104
Trypanosoma cruzi	tubulin delta chain	0.0196	0.2109	0.2082
Brugia malayi	Tubulin alpha chain	0.063	0.7445	0.7445
Echinococcus multilocularis	Tubulin beta 2C chain	0.0837	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0461	0.536	0.536
Schistosoma mansoni	alpha tubulin	0.063	0.7445	0.7445
Leishmania major	alpha tubulin	0.063	0.7445	0.7437
Echinococcus granulosus	integrin linked protein kinase	0.003	0.0061	0.0061
Echinococcus granulosus	kinase suppressor of Ras 1	0.003	0.0061	0.0061
Echinococcus multilocularis	Spectrin alpha actinin	0.0037	0.0147	0.0147
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.003	0.0061	0.0061
Trypanosoma brucei	beta tubulin	0.0452	0.5259	0.5243
Schistosoma mansoni	protein kinase	0.003	0.0061	0.0061
Echinococcus granulosus	tubulin alpha chain	0.063	0.7445	0.7445
Plasmodium falciparum	tubulin beta chain	0.0837	1	1
Echinococcus granulosus	hypothetical protein	0.0099	0.0914	0.0914
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0037	0.0147	0.0147
Leishmania major	beta tubulin	0.0837	1	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.003	0.0061	0.0061
Schistosoma mansoni	protein kinase	0.003	0.0061	0.0061
Onchocerca volvulus		0.0037	0.0147	0.0361
Schistosoma mansoni	hypothetical protein	0.0099	0.0914	0.0914
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.003	0.0061	0.000000015741
Loa Loa (eye worm)	TK/EGFR protein kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	SRC-1	0.0461	0.536	0.536
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.003	0.0061	0.0061
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0292	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0914	0.0914
Treponema pallidum	cell division protein FtsZ	0.0196	0.2109	0.5
Schistosoma mansoni	apoptosis stimulating of P53	0.0037	0.0147	0.0147
Brugia malayi	SH2 domain containing protein	0.0099	0.0914	0.0914
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0196	0.2109	0.2082
Loa Loa (eye worm)	alpha-tubulin	0.063	0.7445	0.7445
Echinococcus granulosus	tubulin subunit TubB	0.063	0.7445	0.7445
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0461	0.536	0.536
Echinococcus multilocularis	natriuretic peptide receptor 1	0.003	0.0061	0.0061
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0065	0.0065
Entamoeba histolytica	protein kinase, putative	0.003	0.0061	0.000000015741
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.003	0.0061	0.0061
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0517	0.0517
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.003	0.0061	0.0061
Giardia lamblia	Pyruvate kinase	0.0033	0.0094	0.0032
Echinococcus multilocularis	SH2 domain containing protein 7	0.0099	0.0914	0.0914
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0094	0.0169
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Echinococcus granulosus	microtubule associated protein 2	0.0675	0.8004	0.8004
Entamoeba histolytica	hypothetical protein	0.0037	0.0147	0.0086
Echinococcus multilocularis	tubulin subunit TubB	0.063	0.7445	0.7445
Entamoeba histolytica	protein kinase, putative	0.0037	0.0147	0.0086
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	TK/CSK protein kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	TK protein kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0099	0.0914	0.0914
Loa Loa (eye worm)	protein-tyrosine kinase	0.0037	0.0147	0.0147
Brugia malayi	protein-tyrosine kinase	0.0037	0.0147	0.0147
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0099	0.0914	0.0914
Giardia lamblia	Beta tubulin	0.0837	1	1
Echinococcus multilocularis	tubulin alpha chain	0.063	0.7445	0.7445
Leishmania major	epsilon tubulin, putative	0.0452	0.5259	0.5243
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.003	0.0061	0.0061
Echinococcus multilocularis	NCK adaptor protein	0.0136	0.137	0.137
Loa Loa (eye worm)	TK/FER protein kinase	0.003	0.0061	0.0061
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0874	0.0874
Schistosoma mansoni	SH2A	0.0099	0.0914	0.0914
Schistosoma mansoni	hypothetical protein	0.0033	0.0102	0.0102
Trichomonas vaginalis	tubulin gamma chain, putative	0.0452	0.5259	0.5229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.063	0.7445	0.7445
Leishmania major	hypothetical protein, conserved	0.003	0.0061	0.0028
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Brugia malayi	ephrin receptor 1 precursor	0.003	0.0061	0.0061
Echinococcus multilocularis	microtubule associated protein 2	0.0675	0.8004	0.8004
Mycobacterium leprae	cell division protein FtsZ	0.0196	0.2109	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0452	0.5259	0.5243
Trichomonas vaginalis	tubulin epsilon chain, putative	0.063	0.7445	0.743
Onchocerca volvulus		0.003	0.0061	0.0054
Leishmania major	gamma-tubulin	0.0452	0.5259	0.5243
Loa Loa (eye worm)	tubulin beta-2A chain	0.0837	1	1
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0037	0.0147	0.0086
Onchocerca volvulus		0.0037	0.0147	0.0361
Schistosoma mansoni	tubulin subunit beta	0.0837	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0256	0.2841	0.2797
Brugia malayi	Pre-SET motif family protein	0.003	0.0065	0.0065
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0037	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0136	0.137	0.137
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0461	0.536	0.536
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	BEN-1 protein	0.0837	1	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0096	0.0874	0.0874
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0099	0.0914	0.0914
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0423	0.4905	0.4905
Echinococcus multilocularis	integrin linked protein kinase	0.003	0.0061	0.0061
Leishmania major	alpha tubulin	0.063	0.7445	0.7437
Brugia malayi	Variant SH3 domain containing protein	0.0037	0.0147	0.0147
Entamoeba histolytica	protein kinase, putative	0.003	0.0061	0.000000015741
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0196	0.2109	0.5
Schistosoma mansoni	tensin	0.0099	0.0914	0.0914
Brugia malayi	tubulin alpha chain - mouse	0.063	0.7445	0.7445
Loa Loa (eye worm)	transcription factor SMAD2	0.0368	0.422	0.422
Echinococcus granulosus	peroxisome assembly protein 26	0.063	0.7445	0.7445
Echinococcus granulosus	expressed conserved protein	0.0099	0.0914	0.0914
Loa Loa (eye worm)	TK protein kinase	0.0324	0.3682	0.3682
Leishmania major	beta tubulin	0.0837	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.0874	0.0874
Loa Loa (eye worm)	hypothetical protein	0.003	0.0061	0.0061
Schistosoma mansoni	protein kinase	0.003	0.0061	0.0061
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Echinococcus granulosus	Tubulin beta 2C chain	0.0837	1	1
Schistosoma mansoni	dreadlocks/dock	0.0037	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0147	0.0147
Schistosoma mansoni	tubulin subunit delta	0.0196	0.2109	0.2109
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0037	0.0147	0.0147
Schistosoma mansoni	serine/threonine RGC	0.003	0.0061	0.0061
Onchocerca volvulus		0.0037	0.0147	0.0361
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0461	0.536	0.536
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.003	0.0061	0.0054
Entamoeba histolytica	tubulin alpha chain, putative	0.063	0.7445	0.743
Echinococcus granulosus	beta tubulin	0.0837	1	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0099	0.0914	0.0914
Schistosoma mansoni	tubulin subunit gamma	0.0452	0.5259	0.5259
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0037	0.0147	0.0147
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.0874	0.0874
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.003	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0461	0.536	0.536
Brugia malayi	hypothetical protein	0.004	0.0179	0.0179
Brugia malayi	Protein kinase domain containing protein	0.0129	0.1284	0.1284
Echinococcus granulosus	tyrosine protein kinase csk	0.003	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0914	0.0914
Schistosoma mansoni	pyruvate kinase	0.0033	0.0094	0.0094
Brugia malayi	SH2 domain containing protein	0.0129	0.1284	0.1284
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0147	0.0086
Plasmodium falciparum	protein kinase, putative	0.003	0.0061	0.0028
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0099	0.0914	0.0914
Echinococcus multilocularis	epidermal growth factor receptor	0.003	0.0061	0.0061
Entamoeba histolytica	tubulin family protein	0.0837	1	1
Echinococcus multilocularis	transfer RNA-Thr	0.003	0.0061	0.0061
Plasmodium vivax	tubulin alpha chain, putative	0.063	0.7445	0.7437
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0099	0.0914	0.0914
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0147	0.0086
Trichomonas vaginalis	tubulin beta chain, putative	0.0256	0.2841	0.2797
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.1284	0.1284
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0147	0.0086
Brugia malayi	SH2 domain containing protein	0.0099	0.0914	0.0914
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	TK/FER protein kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	TK protein kinase	0.003	0.0061	0.0061
Trypanosoma brucei	pyruvate kinase 1, putative	0.0033	0.0094	0.0061
Loa Loa (eye worm)	tubulin gamma chain	0.0452	0.5259	0.5259
Schistosoma mansoni	protein kinase	0.003	0.0061	0.0061
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0037	0.0147	0.0147
Echinococcus granulosus	activated cdc42 kinase 1	0.003	0.0061	0.0061
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0037	0.0147	0.0147
Echinococcus granulosus	tubulin alpha chain	0.063	0.7445	0.7445
Brugia malayi	Raf kinase	0.003	0.0061	0.0061
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0837	1	1
Onchocerca volvulus		0.0129	0.1284	0.4428
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Brugia malayi	tubulin alpha-2 chain	0.063	0.7445	0.7445
Schistosoma mansoni	nck2/grb4	0.0136	0.137	0.137
Echinococcus granulosus	SH2 motif	0.0099	0.0914	0.0914
Giardia lamblia	Gamma tubulin	0.0452	0.5259	0.5229
Echinococcus granulosus	Tubulin beta 2C chain	0.0837	1	1
Echinococcus multilocularis	SH2 motif	0.0099	0.0914	0.0914
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Brugia malayi	SH2 domain containing protein	0.0099	0.0914	0.0914
Echinococcus granulosus	tubulin gamma 1 chain	0.0452	0.5259	0.5259
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0423	0.1637
Brugia malayi	Tubulin alpha chain	0.0196	0.2109	0.2109
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0037	0.0147	0.0147
Schistosoma mansoni	adapter molecule crk	0.0136	0.137	0.137
Echinococcus granulosus	tyrosine protein kinase pr2	0.003	0.0061	0.0061
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0461	0.536	0.536
Plasmodium falciparum	tyrosine kinase-like protein	0.003	0.0061	0.0028
Echinococcus granulosus	Spectrin alpha actinin	0.0037	0.0147	0.0147
Schistosoma mansoni	suppressor of cytokine signaling	0.0099	0.0914	0.0914
Entamoeba histolytica	hypothetical protein	0.004	0.0179	0.0118
Onchocerca volvulus		0.0099	0.0914	0.3104
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0914	0.0914
Echinococcus granulosus	Tubulin alpha 1 chain	0.063	0.7445	0.7445
Trichomonas vaginalis	tubulin epsilon chain, putative	0.063	0.7445	0.743
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.003	0.0061	0.0061
Echinococcus granulosus	tyrosine kinase	0.003	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Loa Loa (eye worm)	BEN-1 protein	0.0837	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.1284	0.1284
Trypanosoma brucei	alpha tubulin	0.063	0.7445	0.7437
Loa Loa (eye worm)	TK/FAK protein kinase	0.003	0.0061	0.0061
Echinococcus multilocularis	protein kinase	0.003	0.0061	0.0061
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0196	0.2109	1
Echinococcus granulosus	tubulin alpha	0.0452	0.5259	0.5259
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0292	0.0292
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Plasmodium vivax	tyrosine kinase-like protein, putative	0.003	0.0061	0.0028
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.063	0.7445	0.743
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.003	0.0061	0.0028
Onchocerca volvulus		0.003	0.0061	0.0054
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.003	0.0061	0.0061
Entamoeba histolytica	hypothetical protein, conserved	0.0037	0.0147	0.0086
Echinococcus multilocularis	SH2 motif	0.0099	0.0914	0.0914
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	TK protein kinase	0.003	0.0061	0.0061
Trypanosoma cruzi	tubulin gamma chain	0.0452	0.5259	0.5243
Loa Loa (eye worm)	RGC/RGC protein kinase	0.003	0.0061	0.0061
Brugia malayi	hypothetical protein	0.0099	0.0914	0.0914
Schistosoma mansoni	C-fyn	0.0037	0.0147	0.0147
Brugia malayi	Immunoglobulin I-set domain containing protein	0.003	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Entamoeba histolytica	tubulin alpha-1 chain	0.063	0.7445	0.743
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0837	1	1
Schistosoma mansoni	eps8-related protein	0.0037	0.0147	0.0147
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.003	0.0061	0.0028
Echinococcus granulosus	Tubulin beta 2C chain	0.0837	1	1
Entamoeba histolytica	protein kinase, putative	0.0099	0.0914	0.0858
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0099	0.0914	0.0914
Schistosoma mansoni	GTPase activating protein	0.0099	0.0914	0.0914
Trichomonas vaginalis	TKL family protein kinase	0.003	0.0061	0.000000015741
Echinococcus granulosus	tensin	0.0099	0.0914	0.0914
Echinococcus granulosus	tubulin delta chain	0.0196	0.2109	0.2109
Toxoplasma gondii	STE kinase	0.003	0.0061	0.0028
Leishmania major	alpha tubulin	0.063	0.7445	0.7437
Schistosoma mansoni	tensin	0.0099	0.0914	0.0914
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0166	0.174	0.174
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0099	0.0914	0.0914
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0099	0.0914	0.0914
Brugia malayi	Peripheral plasma membrane protein CASK	0.0037	0.0147	0.0147
Schistosoma mansoni	Dab2-interacting protein-like	0.0037	0.0147	0.0147
Toxoplasma gondii	beta tubulin	0.0837	1	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.003	0.0061	0.0061
Echinococcus granulosus	retinal guanylyl cyclase 2	0.003	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Onchocerca volvulus		0.003	0.0061	0.0054
Brugia malayi	Variant SH3 domain containing protein	0.0136	0.137	0.137
Trypanosoma brucei	alpha tubulin	0.063	0.7445	0.7437
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0212	0.2295	0.2295
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0099	0.0914	0.0914
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.1284	0.1284
Echinococcus multilocularis	tensin	0.0099	0.0914	0.0914
Echinococcus multilocularis	tubulin beta 1 chain	0.0837	1	1
Leishmania major	alpha tubulin	0.063	0.7445	0.7437
Trypanosoma brucei	epsilon tubulin	0.0452	0.5259	0.5243
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0196	0.2109	0.206
Plasmodium vivax	tubulin beta chain, putative	0.0837	1	1
Brugia malayi	Guanylyl cyclase protein 23	0.003	0.0061	0.0061
Giardia lamblia	Alpha-tubulin	0.063	0.7445	0.743
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0434	0.5028	0.5028
Leishmania major	beta tubulin	0.0837	1	1
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	TK/FER protein kinase	0.003	0.0061	0.0061
Echinococcus multilocularis	protein kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0914	0.0914
Trichomonas vaginalis	tubulin alpha chain, putative	0.0452	0.5259	0.5229
Schistosoma mansoni	tubulin subunit beta	0.0837	1	1
Brugia malayi	Pre-SET motif family protein	0.0212	0.2295	0.2295
Loa Loa (eye worm)	hypothetical protein	0.003	0.0061	0.0061
Toxoplasma gondii	alpha-tubulin I, putative	0.063	0.7445	0.7437
Loa Loa (eye worm)	RGC/RGC protein kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.003	0.0061	0.0061
Echinococcus granulosus	SHC transforming protein 3	0.0099	0.0914	0.0914
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0094	0.0061
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0061	0.0061
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0423	0.0423
Brugia malayi	Immunoglobulin I-set domain containing protein	0.003	0.0061	0.0061
Brugia malayi	Variant SH3 domain containing protein	0.0136	0.137	0.137
Echinococcus multilocularis	Tubulin beta 2C chain	0.0837	1	1
Brugia malayi	Guanylate kinase family protein	0.0037	0.0147	0.0147
Trypanosoma brucei	zeta tubulin, putative	0.0196	0.2109	0.2082
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0461	0.536	0.536
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0147	0.0147
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0914	0.0914
Trichomonas vaginalis	tubulin beta chain, putative	0.063	0.7445	0.743
Echinococcus multilocularis	N chimaerin	0.0099	0.0914	0.0914
Echinococcus granulosus	tubulin beta 4A class IVa	0.0837	1	1
Schistosoma mansoni	tubulin subunit epsilon	0.0452	0.5259	0.5259
Echinococcus multilocularis	protein tyrosine kinase	0.003	0.0061	0.0061
Echinococcus granulosus	growth factor receptor bound protein 2	0.0136	0.137	0.137
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0147	0.0086
Echinococcus granulosus	tyrosine protein kinase	0.003	0.0061	0.0061
Onchocerca volvulus		0.0129	0.1284	0.4428
Echinococcus multilocularis	peroxisome assembly protein 26	0.063	0.7445	0.7445
Echinococcus multilocularis	heat shock protein 70	0.003	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.003	0.0061	0.000000015741
Schistosoma mansoni	tubulin subunit alpha	0.063	0.7445	0.7445
Entamoeba histolytica	hypothetical protein	0.003	0.0066	0.0004
Giardia lamblia	Alpha-tubulin	0.063	0.7445	0.743
Echinococcus granulosus	protein tyrosine kinase	0.003	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.003	0.0061	0.000000015741
Loa Loa (eye worm)	TK/FER protein kinase	0.003	0.0061	0.0061
Entamoeba histolytica	tubulin gamma chain	0.0452	0.5259	0.5229
Loa Loa (eye worm)	TK protein kinase	0.003	0.0061	0.0061
Echinococcus multilocularis	activin receptor type	0.003	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0914	0.0914
Leishmania major	alpha tubulin	0.063	0.7445	0.7437
Schistosoma mansoni	tubulin subunit beta	0.0837	1	1
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0065	0.0065
Brugia malayi	Tubulin gamma chain	0.0452	0.5259	0.5259
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0096	0.0874	0.0874
Echinococcus granulosus	tyrosine protein kinase HCK	0.0324	0.3682	0.3682
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.003	0.0061	0.0061
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.003	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0099	0.0914	0.0914
Brugia malayi	hypothetical protein	0.0028	0.0033	0.0033
Brugia malayi	Variant SH3 domain containing protein	0.0099	0.0914	0.0914
Echinococcus granulosus	beta tubulin	0.0837	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.003	0.0061	0.0061
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.003	0.0061	0.0028
Toxoplasma gondii	beta-tubulin, putative	0.0837	1	1
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Echinococcus multilocularis	tubulin subunit beta	0.0837	1	1
Schistosoma mansoni	tyrosine protein kinase	0.003	0.0061	0.0061
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0065	0.0065
Echinococcus multilocularis	tubulin alpha chain	0.063	0.7445	0.7445
Loa Loa (eye worm)	SH2 domain-containing protein	0.0099	0.0914	0.0914
Entamoeba histolytica	hypothetical protein	0.003	0.0066	0.0004
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0099	0.0914	0.0914
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0094	0.0094
Echinococcus multilocularis	signal transduction protein lnk realted	0.0099	0.0914	0.0914
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Echinococcus granulosus	tubulin subunit beta	0.0837	1	1
Schistosoma mansoni	ephrin receptor	0.003	0.0061	0.0061
Loa Loa (eye worm)	TK/Met protein kinase	0.003	0.0061	0.0061
Echinococcus granulosus	c src tyrosine kinase	0.0166	0.174	0.174
Giardia lamblia	Beta tubulin	0.0837	1	1
Plasmodium vivax	tubulin epsilon chain, putative	0.0452	0.5259	0.5243
Brugia malayi	protein-tyrosine kinase	0.0423	0.4905	0.4905
Echinococcus granulosus	tubulin alpha 3 chain	0.063	0.7445	0.7445
Toxoplasma gondii	pyruvate kinase PyK1	0.0033	0.0094	0.0061
Echinococcus granulosus	activated cdc42 kinase 1	0.003	0.0061	0.0061
Echinococcus multilocularis	tyrosine protein kinase pr2	0.003	0.0061	0.0061
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0094	0.0169
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0874	0.0874
Schistosoma mansoni	pyruvate kinase	0.0033	0.0094	0.0094
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0292	0.0292
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0099	0.0914	0.0914
Loa Loa (eye worm)	p53BP2	0.0037	0.0147	0.0147
Echinococcus granulosus	tyrosine kinase	0.0129	0.1284	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0914	0.0914
Brugia malayi	Tubulin beta chain	0.0256	0.2841	0.2841
Echinococcus granulosus	NCK adaptor protein	0.0136	0.137	0.137
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.1284	0.1284
Leishmania major	alpha tubulin	0.063	0.7445	0.7437
Schistosoma mansoni	protein kinase	0.003	0.0061	0.0061
Trypanosoma brucei	pyruvate kinase 1	0.0033	0.0094	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0147	0.0086
Echinococcus multilocularis	SHC transforming protein 3	0.0099	0.0914	0.0914
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.003	0.0061	0.0061
Echinococcus multilocularis	Tubulin beta 2C chain	0.0837	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0147	0.0114
Loa Loa (eye worm)	TK/FER protein kinase	0.003	0.0061	0.0061
Echinococcus multilocularis	receptor type guanylyl cyclase	0.003	0.0061	0.0061
Brugia malayi	Receptor family ligand binding region containing protein	0.003	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0129	0.1284	0.1284
Echinococcus multilocularis	tubulin alpha	0.0452	0.5259	0.5259
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0461	0.536	0.536
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0393	0.4535	0.4535
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.003	0.0061	0.0054
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0461	0.536	0.536
Echinococcus multilocularis	geminin	0.0349	0.3989	0.3989
Brugia malayi	hypothetical protein	0.0129	0.1284	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0094	0.0094
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.003	0.0061	0.0061
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.003	0.0061	0.0061
Trypanosoma brucei	beta tubulin	0.0837	1	1
Echinococcus multilocularis	SH2 motif	0.0099	0.0914	0.0914
Schistosoma mansoni	alpha tubulin	0.063	0.7445	0.7445
Plasmodium vivax	protein kinase, putative	0.003	0.0061	0.0028
Loa Loa (eye worm)	TK/ABL protein kinase	0.0129	0.1284	0.1284
Leishmania major	alpha tubulin	0.063	0.7445	0.7437
Giardia lamblia	Protein 21.1	0.003	0.0061	0.000000015741
Schistosoma mansoni	tyrosine kinase	0.0166	0.174	0.174
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0094	0.0094
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.003	0.0061	0.0061
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0374	0.4295	0.426
Leishmania major	beta tubulin	0.0837	1	1
Schistosoma mansoni	protein kinase	0.003	0.0061	0.0061
Schistosoma mansoni	alpha tubulin	0.063	0.7445	0.7445
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0914	0.0914
Onchocerca volvulus		0.0129	0.1284	0.4428
Brugia malayi	Variant SH3 domain containing protein	0.0037	0.0147	0.0147
Leishmania major	pyruvate kinase	0.0033	0.0094	0.0061
Brugia malayi	SH2 domain containing protein	0.0099	0.0914	0.0914
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0037	0.0147	0.0147
Echinococcus multilocularis	ephrin type A receptor 4 A	0.003	0.0061	0.0061
Entamoeba histolytica	tubulin family protein	0.0837	1	1
Leishmania major	pyruvate kinase	0.0033	0.0094	0.0061
Echinococcus granulosus	Tubulin alpha 1 chain	0.063	0.7445	0.7445
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0033	0.0094	0.0094
Onchocerca volvulus		0.0129	0.1284	0.4428
Plasmodium falciparum	protein kinase, putative	0.003	0.0061	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0914	0.0914
Brugia malayi	alpha-tubulin	0.063	0.7445	0.7445
Leishmania major	beta tubulin	0.0837	1	1
Entamoeba histolytica	SH2 domain containing protein	0.0099	0.0914	0.0858
Trichomonas vaginalis	tubulin, putative	0.0196	0.2109	0.206
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0102	0.0102
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0033	0.0094	0.0094
Loa Loa (eye worm)	TK/FER protein kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	tubulin beta chain	0.0837	1	1
Onchocerca volvulus		0.0037	0.0147	0.0361
Schistosoma mansoni	hypothetical protein	0.0349	0.3989	0.3989
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0099	0.0914	0.0914
Echinococcus multilocularis	tubulin delta chain	0.0196	0.2109	0.2109
Schistosoma mansoni	tubulin subunit beta	0.0837	1	1
Brugia malayi	Tensin	0.0099	0.0914	0.0914
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0914	0.0914
Leishmania major	protein kinase, putative	0.003	0.0061	0.0028
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.003	0.0061	0.0061
Schistosoma mansoni	protein kinase	0.003	0.0061	0.0061
Onchocerca volvulus		0.0256	0.2841	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.003	0.0061	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0914	0.0914
Echinococcus granulosus	retinal guanylyl cyclase 2	0.003	0.0061	0.0061
Echinococcus multilocularis	tubulin alpha 1C chain	0.063	0.7445	0.7445
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0099	0.0914	0.0914
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0461	0.536	0.536
Echinococcus granulosus	geminin	0.0349	0.3989	0.3989
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.003	0.0066	0.0004
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0166	0.174	0.174
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0037	0.0147	0.0147
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0099	0.0914	0.3104
Trypanosoma brucei	tubulin gamma chain	0.0452	0.5259	0.5243
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0099	0.0914	0.0914
Plasmodium falciparum	tubulin delta chain, putative	0.0196	0.2109	0.2082
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Trichomonas vaginalis	tubulin beta chain, putative	0.063	0.7445	0.743
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.003	0.0061	0.0061
Schistosoma mansoni	tubulin subunit beta	0.0196	0.2109	0.2109
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0461	0.536	0.536
Trichomonas vaginalis	conserved hypothetical protein	0.0196	0.2109	0.206
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0914	0.0914
Loa Loa (eye worm)	RGC/RGC protein kinase	0.003	0.0061	0.0061
Schistosoma mansoni	sorting nexin	0.0037	0.0147	0.0147
Trichomonas vaginalis	tubulin alpha chain, putative	0.0837	1	1
Echinococcus granulosus	epidermal growth factor receptor	0.003	0.0061	0.0061
Loa Loa (eye worm)	TK/ROR protein kinase	0.003	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0461	0.536	0.536
Schistosoma mansoni	tubulin subunit alpha	0.0196	0.2109	0.2109
Echinococcus multilocularis	expressed protein	0.0037	0.0147	0.0147
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Loa Loa (eye worm)	tubulin beta-4 chain	0.0837	1	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0061	0.0061
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0423	0.0423
Echinococcus multilocularis	kinase suppressor of Ras 1	0.003	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.003	0.0061	0.000000015741
Schistosoma mansoni	sorbin	0.0037	0.0147	0.0147
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0129	0.1284	0.1284
Schistosoma mansoni	hypothetical protein	0.0349	0.3989	0.3989
Onchocerca volvulus		0.0241	0.2655	0.9333
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0196	0.2109	0.206
Trichomonas vaginalis	tubulin beta chain, putative	0.063	0.7445	0.743
Echinococcus multilocularis	insulin receptor	0.003	0.0061	0.0061
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0292	0.0292
Onchocerca volvulus		0.003	0.0061	0.0054
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0179	0.0179
Echinococcus granulosus	tubulin alpha 3 chain	0.063	0.7445	0.7445
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0147	0.0114
Trypanosoma brucei	zeta tubulin	0.0196	0.2109	0.2082
Echinococcus granulosus	alpha tubulin	0.063	0.7445	0.7445
Onchocerca volvulus	Tyrosine kinase homolog	0.003	0.0061	0.0054
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0065	0.0065
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.1284	0.1284
Loa Loa (eye worm)	tubulin alpha chain	0.063	0.7445	0.7445
Echinococcus multilocularis	tyrosine protein kinase csk	0.003	0.0061	0.0061
Trichomonas vaginalis	tubulin, putative	0.0256	0.2841	0.2797
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0179	0.0179
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0099	0.0914	0.0914
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.003	0.0061	0.0061
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Onchocerca volvulus		0.0099	0.0914	0.3104
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0461	0.536	0.536
Loa Loa (eye worm)	hypothetical protein	0.003	0.0061	0.0061
Trypanosoma cruzi	paraflagellar rod protein 5, putative	0.0037	0.0147	0.0114
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0324	0.3682	0.3682
Plasmodium vivax	tyrosine kinase-like protein, putative	0.003	0.0061	0.0028
Echinococcus granulosus	nostrin	0.0037	0.0147	0.0147
Loa Loa (eye worm)	tubulin alpha 2	0.0178	0.1878	0.1878
Brugia malayi	Protein kinase domain containing protein	0.0129	0.1284	0.1284
Leishmania major	beta tubulin	0.0837	1	1
Onchocerca volvulus	LIM and SH3 domain protein homolog	0.0037	0.0147	0.0361
Leishmania major	beta tubulin	0.0837	1	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.003	0.0061	0.0061
Loa Loa (eye worm)	TK protein kinase	0.0423	0.4905	0.4905
Entamoeba histolytica	hypothetical protein	0.0037	0.0147	0.0086
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.003	0.0061	0.0061
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0423	0.4905	0.4905
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0051	0.0051
Entamoeba histolytica	ankyrin repeat protein	0.003	0.0061	0.000000015741
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.003	0.0061	0.0061
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0129	0.1284	0.123
Schistosoma mansoni	hypothetical protein	0.004	0.0179	0.0179
Echinococcus granulosus	tyrosine protein kinase csk	0.003	0.0061	0.0061
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.003	0.0061	0.0061
Trichomonas vaginalis	tubulin gamma chain, putative	0.0837	1	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0147	0.0147
Trypanosoma brucei	alpha tubulin	0.063	0.7445	0.7437
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0065	0.0032
Entamoeba histolytica	protein kinase, putative	0.003	0.0066	0.0004
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.003	0.0061	0.0061
Entamoeba histolytica	unconventional myosin IB	0.0037	0.0147	0.0086
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Brugia malayi	hypothetical protein	0.003	0.0061	0.0061
Leishmania major	beta tubulin	0.0837	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0037	0.0147	0.0147
Echinococcus granulosus	tubulin alpha 1C chain	0.063	0.7445	0.7445
Leishmania major	beta tubulin	0.0837	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.063	0.7445	0.743
Plasmodium vivax	pyruvate kinase, putative	0.0033	0.0094	0.0061
Brugia malayi	bone morphogenetic protein type 1 receptor	0.003	0.0061	0.0061
Schistosoma mansoni	tubulin subunit beta	0.0837	1	1
Trypanosoma cruzi	protein kinase, putative	0.003	0.0061	0.0028
Echinococcus multilocularis	tubulin alpha 3 chain	0.063	0.7445	0.7445
Leishmania major	beta tubulin	0.0837	1	1
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Schistosoma mansoni	ephrin receptor	0.003	0.0061	0.0061
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0452	0.5259	0.5243
Leishmania major	delta tubulin, putative	0.0196	0.2109	0.2082
Echinococcus multilocularis	beta tubulin	0.0837	1	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.003	0.0061	0.0061
Leishmania major	beta tubulin	0.0837	1	1
Onchocerca volvulus	Putative cortactin	0.0037	0.0147	0.0361
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0166	0.174	0.174
Echinococcus multilocularis	tyrosine kinase	0.0129	0.1284	0.1284
Mycobacterium ulcerans	cell division protein FtsZ	0.0196	0.2109	1
Trichomonas vaginalis	conserved hypothetical protein	0.0196	0.2109	0.206
Brugia malayi	Protein kinase domain containing protein	0.0129	0.1284	0.1284
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0434	0.5028	0.4997
Schistosoma mansoni	hypothetical protein	0.0037	0.0147	0.0147
Brugia malayi	C-terminal src kinase protein 1	0.003	0.0061	0.0061
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0037	0.0147	0.0147
Schistosoma mansoni	run and tbc1 domain containing	0.0037	0.0147	0.0147
Leishmania major	alpha tubulin	0.063	0.7445	0.7437
Loa Loa (eye worm)	TK/INSR protein kinase	0.003	0.0061	0.0061
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.003	0.0061	0.0061
Loa Loa (eye worm)	SH2 domain-containing protein	0.0099	0.0914	0.0914
Loa Loa (eye worm)	hypothetical protein	0.003	0.0061	0.0061
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0423	0.1637
Leishmania major	hypothetical protein, conserved	0.0037	0.0147	0.0114
Echinococcus granulosus	raf serine:threonine protein kinase	0.003	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0147	0.0147
Onchocerca volvulus		0.0099	0.0914	0.3104
Echinococcus multilocularis	tubulin alpha 3 chain	0.063	0.7445	0.7445
Loa Loa (eye worm)	beta-tubulin	0.0837	1	1
Leishmania major	beta tubulin	0.0837	1	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0423	0.0423
Echinococcus multilocularis	protein KINase family member (kin 25)	0.003	0.0061	0.0061
Plasmodium falciparum	alpha tubulin 1	0.063	0.7445	0.7437
Loa Loa (eye worm)	tubulin alpha chain	0.063	0.7445	0.7445
Loa Loa (eye worm)	TK/EPH protein kinase	0.003	0.0061	0.0061
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0423	0.4905	0.4905
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0099	0.0914	0.0914
Trypanosoma brucei	Pseudokinase, putative	0.003	0.0061	0.0028
Echinococcus granulosus	SH2 domain containing protein 7	0.0099	0.0914	0.0914
Trypanosoma cruzi	tubulin delta chain	0.0196	0.2109	0.2082
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.0037	0.0147	0.0147
Trypanosoma cruzi	zeta tubulin, putative	0.0196	0.2109	0.2082
Toxoplasma gondii	protein kinase	0.003	0.0061	0.0028
Echinococcus granulosus	tyrosine kinase	0.0423	0.4905	0.4905
Echinococcus granulosus	tyrosine protein kinase Blk	0.0423	0.4905	0.4905
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0461	0.536	0.536
Brugia malayi	Tubulin alpha-2 chain	0.063	0.7445	0.7445
Loa Loa (eye worm)	TK/RYK protein kinase	0.003	0.0061	0.0061
Brugia malayi	SH2 domain containing protein	0.0099	0.0914	0.0914
Echinococcus granulosus	tyrosine protein kinase shark	0.0129	0.1284	0.1284
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0094	0.0094
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0037	0.0147	0.0147
Loa Loa (eye worm)	TK protein kinase	0.003	0.0061	0.0061
Brugia malayi	Variant SH3 domain containing protein	0.0037	0.0147	0.0147
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0129	0.1284	0.1284
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0129	0.1284	0.1284
Schistosoma mansoni	protein kinase	0.003	0.0061	0.0061
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0094	0.0061
Echinococcus granulosus	tubulin alpha 1C chain	0.063	0.7445	0.7445
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.003	0.0061	0.0061
Schistosoma mansoni	signal transduction protein lnk-related	0.0099	0.0914	0.0914
Echinococcus granulosus	fibroblast growth factor receptor 4	0.003	0.0061	0.0061
Echinococcus granulosus	SH2 motif	0.0099	0.0914	0.0914
Schistosoma mansoni	tubulin subunit beta	0.0837	1	1
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0094	0.0094
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0037	0.0147	0.0147
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0147	0.0086
Echinococcus multilocularis	intersectin 2	0.0037	0.0147	0.0147
Loa Loa (eye worm)	TK protein kinase	0.003	0.0061	0.0061
Trypanosoma brucei	protein kinase, putative	0.003	0.0061	0.0028
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Schistosoma mansoni	growth factor receptor-bound protein	0.0136	0.137	0.137
Trypanosoma cruzi	zeta tubulin, putative	0.0196	0.2109	0.2082
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Trypanosoma brucei	tubulin delta chain	0.0196	0.2109	0.2082
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.003	0.0061	0.0061
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0099	0.0914	0.0858
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0099	0.0914	0.0914
Trichomonas vaginalis	tubulin, putative	0.0256	0.2841	0.2797
Onchocerca volvulus		0.003	0.0065	0.0067
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Echinococcus multilocularis	tubulin gamma 1 chain	0.0452	0.5259	0.5259
Loa Loa (eye worm)	RGC/RGC protein kinase	0.003	0.0061	0.0061
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0099	0.0914	0.0914
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Onchocerca volvulus		0.003	0.0061	0.0054
Loa Loa (eye worm)	TK protein kinase	0.003	0.0061	0.0061
Schistosoma mansoni	hypothetical protein	0.0037	0.0147	0.0147
Schistosoma mansoni	protein kinase	0.003	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.003	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.003	0.0065	0.0065
Schistosoma mansoni	protein kinase	0.003	0.0061	0.0061
Echinococcus granulosus	tubulin alpha chain	0.063	0.7445	0.7445
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0423	0.0392
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0099	0.0914	0.0914
Schistosoma mansoni	tyrosine kinase	0.0166	0.174	0.174
Loa Loa (eye worm)	tubulin beta chain	0.0196	0.2109	0.2109
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Trypanosoma brucei	beta tubulin	0.0837	1	1
Echinococcus granulosus	insulin receptor	0.003	0.0061	0.0061
Trichomonas vaginalis	set domain proteins, putative	0.0241	0.2655	0.261
Loa Loa (eye worm)	TK/ALK protein kinase	0.003	0.0061	0.0061
Echinococcus granulosus	retinal guanylyl cyclase 2	0.003	0.0061	0.0061
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.0874	0.0874
Schistosoma mansoni	growth factor receptor-bound protein	0.0136	0.137	0.137
Schistosoma mansoni	vav2	0.0099	0.0914	0.0914
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.003	0.0061	0.0028
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.0874	0.0874
Plasmodium falciparum	alpha tubulin 2	0.063	0.7445	0.7437
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0393	0.4535	0.4535
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Trypanosoma brucei	alpha tubulin	0.063	0.7445	0.7437
Brugia malayi	Tyrosine-protein kinase PR2	0.003	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0147	0.0147
Loa Loa (eye worm)	serine/threonine protein kinase	0.003	0.0061	0.0061
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0461	0.536	0.536
Echinococcus granulosus	tyrosine protein kinase Srms	0.0129	0.1284	0.1284
Leishmania major	alpha tubulin	0.063	0.7445	0.7437
Brugia malayi	SRC-1	0.0461	0.536	0.536
Leishmania major	zeta tubulin, putative	0.0196	0.2109	0.2082
Plasmodium falciparum	tubulin gamma chain	0.0452	0.5259	0.5243
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0099	0.0914	0.0914
Plasmodium falciparum	tubulin epsilon chain, putative	0.0452	0.5259	0.5243
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0147	0.0147
Brugia malayi	Variant SH3 domain containing protein	0.0099	0.0914	0.0914
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0099	0.0914	0.0914
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.003	0.0061	0.0061
Entamoeba histolytica	hypothetical protein	0.004	0.0179	0.0118
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0147	0.0086
Echinococcus granulosus	signal transduction protein lnk realted	0.0099	0.0914	0.0914
Leishmania major	alpha tubulin	0.063	0.7445	0.7437
Trypanosoma brucei	Flagellum attachment zone protein 20	0.003	0.0061	0.0028
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0099	0.0914	0.0914
Leishmania major	beta tubulin	0.0837	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0037	0.0147	0.0147
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.003	0.0061	0.0061
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.003	0.0061	0.0061
Schistosoma mansoni	protein kinase	0.003	0.0061	0.0061
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0129	0.1284	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0914	0.0914
Echinococcus granulosus	src region	0.0037	0.0147	0.0147
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0099	0.0914	0.0914
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0037	0.0147	0.0147
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0099	0.0914	0.0914
Echinococcus multilocularis	tubulin alpha 1C chain	0.063	0.7445	0.7445
Loa Loa (eye worm)	tubulin beta-1 chain	0.0837	1	1
Brugia malayi	Protein kinase domain containing protein	0.003	0.0061	0.0061
Chlamydia trachomatis	pyruvate kinase	0.0033	0.0094	0.5
Echinococcus granulosus	receptor type guanylyl cyclase	0.003	0.0061	0.0061
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.0037	0.0147	0.0147
Brugia malayi	Tubulin beta chain	0.0196	0.2109	0.2109
Loa Loa (eye worm)	tubulin alpha-2 chain	0.063	0.7445	0.7445
Trypanosoma brucei	alpha tubulin, putative	0.0256	0.2841	0.2818
Leishmania major	beta tubulin	0.0837	1	1
Echinococcus multilocularis	hypothetical protein	0.063	0.7445	0.7445
Onchocerca volvulus		0.0099	0.0914	0.3104
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	tubulin alpha 2	0.0434	0.5028	0.5028
Trypanosoma cruzi	beta tubulin, putative	0.0837	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.1284	0.1284
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.003	0.0061	0.0061
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.1284	0.1284
Loa Loa (eye worm)	hypothetical protein	0.003	0.0061	0.0061
Loa Loa (eye worm)	TK/DDR protein kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.003	0.0061	0.0061
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.003	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0914	0.0914
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.003	0.0061	0.0061
Echinococcus multilocularis	Tubulin beta 2C chain	0.0837	1	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.003	0.0061	0.0061
Schistosoma mansoni	shc transforming protein	0.0099	0.0914	0.0914
Giardia lamblia	Kinase, NEK	0.003	0.0061	0.000000015741
Plasmodium vivax	SET domain protein, putative	0.003	0.0065	0.0032
Echinococcus granulosus	tyrosine protein kinase csk	0.003	0.0061	0.0061
Entamoeba histolytica	hypothetical protein	0.003	0.0066	0.0004
Brugia malayi	RhoGAP domain containing protein	0.0099	0.0914	0.0914
Echinococcus multilocularis	Tubulin alpha 1 chain	0.063	0.7445	0.7445
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0166	0.174	0.174
Brugia malayi	SH3 domain containing protein	0.0037	0.0147	0.0147
Leishmania major	beta tubulin	0.0837	1	1
Plasmodium vivax	tubulin alpha chain, putative	0.063	0.7445	0.7437
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0837	1	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.003	0.0061	0.0028
Echinococcus granulosus	activin receptor type	0.003	0.0061	0.0061
Onchocerca volvulus		0.0129	0.1284	0.4428
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0094	0.0032
Echinococcus multilocularis	tensin	0.0099	0.0914	0.0914
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Echinococcus granulosus	epidermal growth factor receptor	0.003	0.0061	0.0061
Echinococcus granulosus	pyruvate kinase	0.0033	0.0094	0.0094
Brugia malayi	Src substrate cortactin	0.0037	0.0147	0.0147
Trichomonas vaginalis	tubulin beta chain, putative	0.063	0.7445	0.743
Echinococcus multilocularis	tubulin epsilon chain	0.0452	0.5259	0.5259
Plasmodium vivax	delta tubulin, putative	0.0196	0.2109	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0374	0.4295	0.4295
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0147	0.0147
Schistosoma mansoni	suppressor of cytokine signaling	0.0099	0.0914	0.0914
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.003	0.0061	0.0061
Brugia malayi	Tyrosine-protein kinase abl-1	0.0166	0.174	0.174
Echinococcus multilocularis	tyrosine protein kinase csk	0.003	0.0061	0.0061
Echinococcus multilocularis	Tubulin alpha 1 chain	0.063	0.7445	0.7445
Brugia malayi	hypothetical protein	0.003	0.0061	0.0061
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0179	0.0179
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0461	0.536	0.536
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.1284	0.1284
Echinococcus multilocularis	tyrosine protein kinase csk	0.003	0.0061	0.0061
Entamoeba histolytica	hypothetical protein, conserved	0.0037	0.0147	0.0086
Trypanosoma cruzi	protein kinase, putative	0.003	0.0061	0.0028
Trypanosoma brucei	conserved protein	0.0037	0.0147	0.0114
Loa Loa (eye worm)	TK protein kinase	0.003	0.0061	0.0061
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0423	0.1637
Trichomonas vaginalis	tubulin gamma chain, putative	0.0452	0.5259	0.5229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0061	0.0061
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0037	0.0147	0.0147
Trypanosoma brucei	beta tubulin	0.0837	1	1
Entamoeba histolytica	hypothetical protein	0.004	0.0179	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0147	0.0147
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.1284	0.1284
Trichomonas vaginalis	tubulin gamma chain, putative	0.0196	0.2109	0.206
Brugia malayi	Tubulin alpha-2 chain	0.063	0.7445	0.7445
Plasmodium falciparum	tyrosine kinase-like protein	0.003	0.0061	0.0028
Leishmania major	alpha tubulin	0.063	0.7445	0.7437
Trichomonas vaginalis	tubulin beta chain, putative	0.063	0.7445	0.743
Echinococcus granulosus	Tubulin alpha 1 chain	0.063	0.7445	0.7445
Echinococcus granulosus	N chimaerin	0.0099	0.0914	0.0914
Brugia malayi	Myosin tail family protein	0.0037	0.0147	0.0147
Schistosoma mansoni	hypothetical protein	0.0099	0.0914	0.0914
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.003	0.0061	0.0061
Plasmodium falciparum	protein kinase, putative	0.003	0.0061	0.0028
Echinococcus multilocularis	tyrosine protein kinase shark	0.0129	0.1284	0.1284
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0136	0.137	0.137
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0099	0.0914	0.3104
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0423	0.0423
Loa Loa (eye worm)	protein kinase domain-containing protein	0.003	0.0061	0.0061
Schistosoma mansoni	tensin-related	0.0099	0.0914	0.0914
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.003	0.0061	0.0061
Echinococcus multilocularis	nostrin	0.0037	0.0147	0.0147
Echinococcus multilocularis	tyrosine protein kinase csk	0.003	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0423	0.0392
Entamoeba histolytica	hypothetical protein	0.004	0.0179	0.0118
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0136	0.137	0.137
Echinococcus granulosus	expressed protein	0.0037	0.0147	0.0147
Entamoeba histolytica	hypothetical protein	0.0037	0.0147	0.0086
Loa Loa (eye worm)	STAT protein	0.0099	0.0914	0.0914
Schistosoma mansoni	dynamin-associated protein	0.0037	0.0147	0.0147
Schistosoma mansoni	tensin	0.0099	0.0914	0.0914
Brugia malayi	Cell division protein ftsZ	0.0196	0.2109	0.2109
Schistosoma mansoni	tyrosine kinase	0.0129	0.1284	0.1284
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0037	0.0147	0.0147
Trichomonas vaginalis	tubulin alpha chain, putative	0.0256	0.2841	0.2797
Entamoeba histolytica	hypothetical protein	0.0037	0.0147	0.0086
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0065	0.0065
Brugia malayi	Protein kinase domain containing protein	0.0129	0.1284	0.1284
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0423	0.1637
Loa Loa (eye worm)	guanylate kinase	0.0037	0.0147	0.0147
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Entamoeba histolytica	hypothetical protein	0.0037	0.0147	0.0086
Giardia lamblia	Epsilon tubulin	0.0196	0.2109	0.206
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1284	0.1284
Loa Loa (eye worm)	TK/ACK protein kinase	0.003	0.0061	0.0061
Echinococcus multilocularis	FL cytokine receptor	0.003	0.0061	0.0061
Toxoplasma gondii	protein kinase domain-containing protein	0.003	0.0061	0.0028
Brugia malayi	SH2 domain containing protein	0.0129	0.1284	0.1284
Schistosoma mansoni	protein tyrosine kinase	0.003	0.0061	0.0061
Echinococcus granulosus	intersectin 2	0.0037	0.0147	0.0147
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.003	0.0061	0.0061
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0065	0.0065
Echinococcus multilocularis	raf serine:threonine protein kinase	0.003	0.0061	0.0061
Loa Loa (eye worm)	MH2 domain-containing protein	0.0368	0.422	0.422
Leishmania major	protein kinase, putative	0.003	0.0061	0.0028
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0461	0.536	0.536
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0037	0.0147	0.0147
Toxoplasma gondii	beta-1 tubulin, putative	0.0837	1	1
Brugia malayi	Sex muscle abnormal protein 5	0.0136	0.137	0.137
Plasmodium falciparum	pyruvate kinase	0.0033	0.0094	0.0061
Echinococcus multilocularis	activated cdc42 kinase 1	0.003	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.003	0.0061	0.0061
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.003	0.0061	0.0061
Trypanosoma brucei	epsilon tubulin	0.0452	0.5259	0.5243
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0037	0.0147	0.0086
Echinococcus granulosus	tubulin epsilon chain	0.0452	0.5259	0.5259
Entamoeba histolytica	hypothetical protein	0.0037	0.0147	0.0086
Leishmania major	alpha tubulin	0.063	0.7445	0.7437
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0037	0.0147	0.0147

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 0.0915 uM	Agonist activity at human TLR7 expressed in NF-kappaB-stimulated HEK293 cells assessed as induction of secreted alkaline phosphatase expression by reporter gene assay	ChEMBL.	20481492

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1086474

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1126434