Detailed information for compound 1141890

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 298.724 | Formula: C16H11ClN2O2
  • H donors: 1 H acceptors: 3 LogP: 2.62 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCn1nc2c3c1cccc3c(=O)c1c2cccc1Cl
  • InChi: 1S/C16H11ClN2O2/c17-11-5-1-3-9-13(11)16(21)10-4-2-6-12-14(10)15(9)18-19(12)7-8-20/h1-6,20H,7-8H2
  • InChiKey: VJRHSPFNBGKMIJ-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0051 0.0338 0.0333
Onchocerca volvulus 0.0032 0.0158 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Schistosoma mansoni hypothetical protein 0.0258 0.2322 0.27
Onchocerca volvulus 0.0203 0.1794 0.2507
Schistosoma mansoni sugar transporter 0.0032 0.0158 0.0183
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0463 0.0538
Brugia malayi CHD4 protein 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0157
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.009 0.0715 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.0258 0.2322 0.27
Schistosoma mansoni cpg binding protein 0.0061 0.0434 0.0504
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0111
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0983 0.1142
Schistosoma mansoni glucose transport protein 0.0228 0.2036 0.2368
Leishmania major myo-inositol/proton symporter (MIT) 0.0032 0.0158 0.0493
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0017 0.0011 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0695 0.651 0.6508
Leishmania major hypothetical protein, conserved 0.0016 0.0005 0.0015
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0596 0.0591
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0019 0.0031
Trypanosoma brucei metacaspase MCA3 0.0168 0.1464 0.459
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.005 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0695 0.651 0.6508
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.3646 0.424
Echinococcus granulosus dna polymerase eta 0.0019 0.0036 0.0041
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0036 0.0111
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.058 0.1817
Echinococcus granulosus solute carrier family 22 0.0032 0.0158 0.0183
Echinococcus granulosus neutral alpha glucosidase AB 0.0078 0.0596 0.0693
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0083 0.0095
Loa Loa (eye worm) inositol-1 0.0036 0.0193 0.0192
Echinococcus granulosus lysosomal alpha glucosidase 0.0351 0.3211 0.3735
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0118 0.0983 0.1142
Mycobacterium ulcerans hypothetical protein 0.0183 0.1609 0.6551
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.007 0.0525 0.1644
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0413 0.0479
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.007 0.0525 0.087
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.007 0.0525 0.061
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0019 0.0238
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0076 0.058 0.058
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0497 0.0492
Plasmodium vivax hexose transporter 0.0228 0.2036 0.2229
Onchocerca volvulus 0.0032 0.0158 0.0045
Echinococcus multilocularis General substrate transporter 0.0196 0.1729 0.201
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.024 0.0169
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0111
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0063 0.0456 0.1426
Trichomonas vaginalis conserved hypothetical protein 0.0168 0.1464 0.146
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0063 0.0453 0.0527
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0983 0.1142
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0193 0.3168
Trichomonas vaginalis ran, putative 0.0063 0.0453 0.0448
Plasmodium falciparum transportin 0.0016 0.0005 0.0005
Trichomonas vaginalis myo-inositol transporter, putative 0.0032 0.0158 0.0152
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.009 0.0715 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0051 0.0338 0.0393
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0103 0.0839 0.0975
Trichomonas vaginalis glucosylceramidase, putative 0.0695 0.651 0.6508
Echinococcus multilocularis GPCR, family 2 0.0097 0.0784 0.0912
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0036 0.0111
Onchocerca volvulus 0.0056 0.0385 0.0387
Brugia malayi jmjC domain containing protein 0.0016 0.0001 0.0001
Onchocerca volvulus 0.0032 0.0158 0.0045
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0497 0.0496
Brugia malayi Glycosyl hydrolases family 31 protein 0.0351 0.3211 0.3211
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.0128 0.04
Echinococcus multilocularis snurportin 1 0.0912 0.8597 1
Onchocerca volvulus 0.0032 0.0158 0.0045
Entamoeba histolytica hypothetical protein 0.0069 0.0515 0.8622
Onchocerca volvulus 0.0032 0.0158 0.0045
Echinococcus multilocularis zinc finger protein 0.0026 0.0101 0.0117
Schistosoma mansoni hypothetical protein 0.0097 0.0784 0.0912
Brugia malayi Melibiase family protein 0.0079 0.0606 0.0606
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0413 0.0683
Echinococcus multilocularis chromobox protein 1 0.0067 0.0497 0.0577
Toxoplasma gondii transporter, major facilitator family protein 0.0032 0.0158 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0158 0.0152
Echinococcus granulosus translational activator gcn1 0.0016 0.0005 0.0005
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0048 0.0055
Brugia malayi Sugar transporter family protein 0.0228 0.2036 0.2036
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.005 0.0057
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0051 0.0338 0.1059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Plasmodium falciparum calcium-dependent protein kinase 3 0.007 0.0525 0.0574
Schistosoma mansoni protein kinase 0.007 0.0525 0.061
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0019 0.0059
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0036 0.0111
Echinococcus multilocularis translational activator gcn1 0.0016 0.0005 0.0005
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0463 0.0538
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0109 0.0896 0.1042
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Loa Loa (eye worm) hypothetical protein 0.0159 0.1373 0.1372
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0213 0.3514
Trichomonas vaginalis glucosylceramidase, putative 0.1059 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0128 0.0123
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0092 0.0733 0.1214
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0413 0.0479
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.007 0.0525 0.061
Leishmania major glucose transporter/membrane transporter D2, putative 0.0071 0.0528 0.1655
Trypanosoma brucei glucose transporter, putative 0.0071 0.0528 0.1655
Echinococcus granulosus caspase 3 0.0158 0.1364 0.1586
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0019 0.0059
Trypanosoma brucei unspecified product 0.0019 0.0036 0.0111
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0463 0.0462
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.0689 0.0801
Giardia lamblia Prolyl-tRNA synthetase 0.0068 0.0506 1
Echinococcus multilocularis solute carrier family 22 0.0032 0.0158 0.0183
Echinococcus multilocularis lysosomal alpha glucosidase 0.0351 0.3211 0.3735
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0228 0.2036 0.2368
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0036 0.0036
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Brugia malayi glutaminase DH11.1 0.027 0.2438 0.2438
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0036 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0107 0.0102
Trypanosoma brucei glucose transporter, putative 0.0071 0.0528 0.1655
Brugia malayi jmjC domain containing protein 0.0016 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0213 0.0208
Trichomonas vaginalis sugar transport protein, putative 0.0032 0.0158 0.0152
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0157
Onchocerca volvulus 0.0511 0.4747 0.6952
Loa Loa (eye worm) hypothetical protein 0.0258 0.2322 0.2322
Schistosoma mansoni protein kinase 0.007 0.0525 0.061
Trichomonas vaginalis conserved hypothetical protein 0.0168 0.1464 0.146
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0015 0.0017
Brugia malayi Glycosyl hydrolases family 31 protein 0.0078 0.0596 0.0596
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0799 0.7513 0.8739
Brugia malayi CXXC zinc finger family protein 0.0056 0.0385 0.0385
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0413 0.1571
Onchocerca volvulus 0.0032 0.0158 0.0045
Echinococcus granulosus solute carrier family 22 0.0032 0.0158 0.0183
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0097 0.0784 0.0784
Onchocerca volvulus 0.0032 0.0158 0.0045
Plasmodium falciparum calcium-dependent protein kinase 4 0.007 0.0525 0.0574
Trypanosoma cruzi hexose transporter, putative 0.0071 0.0528 0.1655
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0016 0.0005 0.0015
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0019 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0168 0.1464 0.146
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.007 0.0525 0.061
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0035 0.0509
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0168 0.1464 0.146
Echinococcus multilocularis importin 5 0.0016 0.0005 0.0005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0077 0.0072
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0078 0.0596 0.0591
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0043 0.0265 0.1457
Toxoplasma gondii lysine-tRNA ligase 0.0051 0.0338 0.056
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0634 0.5934 0.5934
Leishmania major DNA polymerase eta, putative 0.0019 0.0036 0.0111
Schistosoma mansoni ap endonuclease 0.0019 0.0035 0.004
Brugia malayi chromobox protein homolog 3 0.0038 0.0213 0.0213
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0036 0.0036
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0097 0.0784 0.0912
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0596 0.0591
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0035 0.0038
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0193 0.0187
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0021 0.0052 0.0162
Schistosoma mansoni chromobox protein 0.0067 0.0497 0.0577
Schistosoma mansoni glucose transport protein 0.0228 0.2036 0.2368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0168 0.1464 0.146
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0456 0.045
Echinococcus multilocularis solute carrier family 22 0.0032 0.0158 0.0183
Trypanosoma cruzi glucose transporter, putative 0.0032 0.0158 0.0493
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0077 0.0072
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.1431 0.4484
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0413 0.1292
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0036 0.0031
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0097 0.0784 0.0912
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0068 0.0506 0.8476
Onchocerca volvulus 0.0722 0.6773 1
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0048 0.0047
Trypanosoma cruzi metacaspase, putative 0.0168 0.1464 0.459
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0079 0.0606 0.0704
Toxoplasma gondii Alpha-galactosidase 0.0017 0.0011 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0036 0.0004
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0035 0.0109
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0308 0.2802 0.2802
Trichomonas vaginalis glucosylceramidase, putative 0.0695 0.651 0.6508
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0195 0.0226
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0128 0.1082 0.1258
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0157
Onchocerca volvulus Glucosylceramidase homolog 0.0695 0.651 0.9604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.0044 0.0274 0.0273
Trypanosoma brucei metacaspase MCA2 0.0168 0.1464 0.459
Trichomonas vaginalis sugar transporter, putative 0.0071 0.0528 0.0523
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0999 0.0998
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0148 0.0162
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0063 0.0453 0.0453
Schistosoma mansoni eyes absent homolog 0.0087 0.0685 0.0795
Echinococcus granulosus cpg binding protein 0.0061 0.0434 0.0504
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0221 0.0691
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0157
Loa Loa (eye worm) hypothetical protein 0.0511 0.4747 0.4747
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0097 0.0112
Onchocerca volvulus 0.0032 0.0158 0.0045
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0035 0.004
Loa Loa (eye worm) importin-beta domain-containing protein 0.0016 0.0005 0.0005
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.1059 1 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.007 0.0525 0.0574
Echinococcus multilocularis synaptic vesicle 2 protein 0.0032 0.0158 0.0183
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0035 0.004
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.032 0.1001
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0128 0.0123
Plasmodium vivax sugar transporter, putative 0.0032 0.0158 0.0172
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0158 0.0493
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0083 0.0095
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0015 0.0017
Trypanosoma brucei glucose transporter, putative 0.0071 0.0528 0.1655
Schistosoma mansoni inositol monophosphatase 0.0036 0.0193 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0051 0.0338 0.1059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0193 0.0602
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.1169 0.1168
Loa Loa (eye worm) hypothetical protein 0.0079 0.0606 0.0605
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0077 0.0072
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0015 0.0017
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0035 0.0035
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0078 0.0596 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0228 0.2036 0.2368
Echinococcus granulosus mitogen activated protein kinase 0.0063 0.0456 0.0529
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0035 0.0109
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.1158 0.1346
Trichomonas vaginalis chromobox protein, putative 0.0041 0.024 0.0235
Schistosoma mansoni lozenge 0.0064 0.0465 0.054
Leishmania major lysyl-tRNA synthetase, putative 0.0051 0.0338 0.1059
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0032 0.0158 0.0777
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0035 0.0109
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0077 0.0072
Plasmodium vivax SET domain protein, putative 0.0092 0.0733 0.0802
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0085 0.067 0.0669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Trypanosoma brucei THT1 - hexose transporter, putative 0.0071 0.0528 0.1655
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0063 0.0456 0.0754
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0158 0.0152
Trypanosoma brucei glucose transporter, putative 0.0071 0.0528 0.1655
Leishmania major DNA polymerase kappa, putative 0.0019 0.0036 0.0111
Trichomonas vaginalis importin beta-1, putative 0.0069 0.0515 0.051
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0193 0.0187
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Onchocerca volvulus 0.0032 0.0158 0.0045
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0035 0.0038
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0019 0.0059
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.008 0.0615 0.1926
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0228 0.2036 0.2368
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0118 0.0983 0.1142
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0014 0.0015
Brugia malayi major facilitator superfamily protein 0.0032 0.0158 0.0158
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0269 0.0444
Loa Loa (eye worm) hypothetical protein 0.0038 0.0213 0.0212
Schistosoma mansoni hypothetical protein 0.0097 0.0784 0.0912
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.1218 0.1416
Plasmodium vivax importin-beta 2, putative 0.0085 0.067 0.0733
Trypanosoma brucei glucose transporter, putative 0.0071 0.0528 0.1655
Echinococcus granulosus caspase 8 0.0168 0.1464 0.1703
Schistosoma mansoni importin beta-1 0.0085 0.067 0.0778
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0326 0.2978 0.3463
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0076 0.058 0.0674
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0019 0.0059
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0486 0.0564
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Echinococcus multilocularis geminin 0.0866 0.8156 0.9487
Loa Loa (eye worm) glutaminase 0.027 0.2438 0.2437
Toxoplasma gondii hypothetical protein 0.0056 0.0389 0.0644
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0036 0.0041
Trichomonas vaginalis maltase-glucoamylase, putative 0.0029 0.0128 0.0123
Mycobacterium ulcerans sugar transporter 0.0032 0.0158 0.0509
Loa Loa (eye worm) hypothetical protein 0.0159 0.1373 0.1372
Brugia malayi lysyl-tRNA synthetase 0.0051 0.0338 0.0338
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0116 0.0964 0.0963
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.032 0.1001
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0036 0.0041
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0308 0.2802 0.2802
Trichomonas vaginalis conserved hypothetical protein 0.0168 0.1464 0.146
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0036 0.0003
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.009 0.0715 0.2829
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0505 0.4693 0.4693
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0999 0.0998
Trichomonas vaginalis sugar transporter, putative 0.0071 0.0528 0.0523
Echinococcus granulosus importin subunit beta 1 0.0085 0.067 0.0778
Toxoplasma gondii protein kinase, putative 0.0645 0.6031 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0032 0.0158 0.0509
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0019 0.0022
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0028 0.012 0.0119
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0036 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0528 0.0523
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0168 0.1464 0.146
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0014 0.0015
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0168 0.1464 0.146
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0269 0.0263
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0005 0.0005
Trichomonas vaginalis sugar transporter, putative 0.0071 0.0528 0.0523
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0413 0.0479
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0014 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0036 0.0041
Plasmodium falciparum mitogen-activated protein kinase 2 0.0369 0.3388 0.3709
Plasmodium falciparum importin beta, putative 0.0085 0.067 0.0733
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0128 0.0123
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.1169 0.1169
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0596 0.1867
Schistosoma mansoni cpg binding protein 0.0056 0.0385 0.0447
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Brugia malayi Sugar transporter family protein 0.0032 0.0158 0.0158
Brugia malayi Bromodomain containing protein 0.0042 0.025 0.025
Entamoeba histolytica hypothetical protein 0.0051 0.0338 0.5635
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0111
Schistosoma mansoni sugar transporter 0.0032 0.0158 0.0183
Leishmania major alpha glucosidase II subunit, putative 0.0078 0.0596 0.1867
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1169 0.1358
Echinococcus multilocularis lysosomal alpha glucosidase 0.0351 0.3211 0.3735
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.009 0.0715 0.0782
Echinococcus multilocularis cpg binding protein 0.0061 0.0434 0.0504
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0148 0.1661
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0035 0.0109
Echinococcus granulosus dnaJ subfamily B 0.0396 0.3646 0.424
Schistosoma mansoni sugar transporter 0.0032 0.0158 0.0183
Leishmania major protein kinase, putative 0.007 0.0525 0.1644
Trichomonas vaginalis glucosylceramidase, putative 0.0695 0.651 0.6508
Loa Loa (eye worm) kap beta 3 protein 0.0016 0.0005 0.0005
Loa Loa (eye worm) glutaminase 2 0.027 0.2438 0.2437
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.009 0.0715 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.1218 0.1416
Echinococcus multilocularis caspase 3 0.0158 0.1364 0.1586
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0525 0.061
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.008 0.0615 0.1926
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0019 0.0019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0413 0.1571
Entamoeba histolytica Ran family GTPase 0.0063 0.0453 0.7584
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.009 0.0715 0.0831
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0079 0.0606 0.0601
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0158 0.0158
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0128 0.1082 0.4357
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0111
Brugia malayi Muscleblind-like protein 0.0159 0.1373 0.1373
Echinococcus multilocularis caspase 2 0.0426 0.3936 0.4578
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0168 0.1464 0.2427
Trypanosoma brucei THT1 - hexose transporter, putative 0.0071 0.0528 0.1655
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0021 0.0016
Trypanosoma brucei glucose transporter 2A 0.0071 0.0528 0.1655
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.058 0.1817
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0157
Echinococcus granulosus synaptic vesicle 2 protein 0.0032 0.0158 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0528 0.0523
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0036 0.0111
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0097 0.0112
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0269 0.0263
Plasmodium falciparum calcium-dependent protein kinase 2 0.007 0.0525 0.0574
Plasmodium vivax lysine--tRNA ligase, putative 0.0051 0.0338 0.037
Onchocerca volvulus Putative transporter 0.0032 0.0158 0.0045
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.007 0.0525 0.0524
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.002 0.006
Trichomonas vaginalis glucosylceramidase, putative 0.1059 1 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Onchocerca volvulus Cell death protein 3 homolog 0.0426 0.3936 0.5731
Brugia malayi hypothetical protein 0.0032 0.0158 0.0158
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0036 0.0003
Brugia malayi kap beta 3 protein 0.0016 0.0005 0.0005
Brugia malayi hypothetical protein 0.0087 0.0685 0.0685
Toxoplasma gondii sugar transporter ST3 0.0032 0.0158 0.026
Echinococcus granulosus solute carrier family 22 0.0032 0.0158 0.0183
Leishmania major GTP-binding protein, putative 0.0063 0.0453 0.142
Loa Loa (eye worm) hypothetical protein 0.0071 0.0528 0.0527
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0021 0.0016
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0348 0.319 1
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.6242 0.7261
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0168 0.1464 0.146
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0423 0.1323
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0157
Onchocerca volvulus 0.0032 0.0158 0.0045
Brugia malayi Sugar transporter family protein 0.0032 0.0158 0.0158
Plasmodium falciparum hexose transporter 0.0228 0.2036 0.2229
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0032 0.0158 0.0777
Giardia lamblia DINP protein human, muc B family 0.0019 0.0036 0.0342
Schistosoma mansoni DNA polymerase eta 0.0019 0.0036 0.0041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0077 0.0072
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0068 0.0506 0.0506
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0228 0.2036 0.2368
Toxoplasma gondii sugar transporter ST1 0.0032 0.0158 0.026
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.007 0.0525 0.061
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0157
Onchocerca volvulus 0.0258 0.2322 0.3302
Leishmania major glucose transporter, lmgt3 0.0071 0.0528 0.1655
Echinococcus multilocularis caspase 0.0326 0.2978 0.3463
Trichomonas vaginalis glucosylceramidase, putative 0.0695 0.651 0.6508
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.009 0.0715 1
Schistosoma mansoni ran 0.0063 0.0453 0.0527
Leishmania major metacaspase, putative 0.0168 0.1464 0.459
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.007 0.0525 0.087
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0005 0.0004
Echinococcus granulosus microtubule associated protein 2 0.0667 0.6242 0.7261
Onchocerca volvulus 0.0032 0.0158 0.0045
Trypanosoma brucei metacaspase 5, putative 0.0168 0.1464 0.459
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0019 0.0238
Trypanosoma brucei glucose transporter, putative 0.0071 0.0528 0.1655
Echinococcus granulosus transportin 1 0.0016 0.0005 0.0005
Schistosoma mansoni inositol monophosphatase 0.0036 0.0193 0.0223
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0051 0.0338 0.1261
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0083 0.0136
Loa Loa (eye worm) hypothetical protein 0.0056 0.0383 0.0383
Schistosoma mansoni hypothetical protein 0.021 0.1868 0.2172
Leishmania major mitochondrial DNA polymerase beta 0.0348 0.319 1
Echinococcus granulosus solute carrier family 22 0.0032 0.0158 0.0183
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0157
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0369 0.3388 0.5616
Echinococcus multilocularis peptidase Clp (S14 family) 0.0059 0.0417 0.0484
Brugia malayi Cell death protein 3 precursor 0.0426 0.3936 0.3936
Trichomonas vaginalis glucosylceramidase, putative 0.1059 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0077 0.0072
Plasmodium falciparum protein kinase 6 0.0968 0.9133 1
Schistosoma mansoni caspase-7 (C14 family) 0.0426 0.3936 0.4578
Trichomonas vaginalis glucose transporter, putative 0.0071 0.0528 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Loa Loa (eye worm) hypothetical protein 0.0109 0.0896 0.0896
Schistosoma mansoni importin-beta 2 0.0016 0.0005 0.0005
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0035 0.003
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0983 0.1142
Plasmodium vivax proline--tRNA ligase, putative 0.008 0.0615 0.0673
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0036 0.0111
Brugia malayi Pre-SET motif family protein 0.0634 0.5934 0.5934
Plasmodium falciparum proline--tRNA ligase 0.008 0.0615 0.0673
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0097 0.0112
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.007 0.0525 0.0574
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0005 0.0005
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.0128 0.04
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.1431 0.4484
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.009 0.0715 0.2829
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0019 0.0059
Loa Loa (eye worm) latrophilin receptor protein 2 0.0097 0.0784 0.0784
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0019 0.0019
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0043 0.0265 0.1457
Schistosoma mansoni alpha-glucosidase 0.0302 0.2743 0.319
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0269 0.0312
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0158 0.0158
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0063 0.0453 0.142
Schistosoma mansoni ran 0.0063 0.0453 0.0527
Loa Loa (eye worm) hypothetical protein 0.0308 0.2802 0.2802
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0165 0.1431 0.4484
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0111
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0063 0.0453 0.8917
Echinococcus multilocularis lysyl tRNA synthetase 0.0051 0.0338 0.0393
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0168 0.1464 0.146
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0326 0.2978 0.3463
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.009 0.0715 0.1185
Toxoplasma gondii melibiase subfamily protein 0.0118 0.0983 0.1629
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0063 0.0453 0.0751
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0273 0.0317
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0059 0.0417 0.2425
Schistosoma mansoni zinc finger protein 0.0026 0.0101 0.0117
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0111
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0035 0.003
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0228 0.2036 0.2368
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0097 0.0784 0.0912
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0107 0.0102
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0024 0.0082 0.0194
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0157
Brugia malayi RNA, U transporter 1 0.0243 0.218 0.218
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0036 0.052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1169 0.1358
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0076 0.058 0.0674
Onchocerca volvulus 0.0032 0.0158 0.0045
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0078 0.0596 0.0591
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0128 0.1082 0.4357
Echinococcus granulosus Sugar transporter ERD6 protein 0.0032 0.0158 0.0183
Loa Loa (eye worm) acetyltransferase 0.0143 0.1218 0.1217
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0525 0.061
Onchocerca volvulus 0.003 0.0135 0.001
Loa Loa (eye worm) hypothetical protein 0.0097 0.0784 0.0784
Toxoplasma gondii sugar transporter ST2 0.0032 0.0158 0.026
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0063 0.0453 0.0496
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0157
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0036 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0456 0.0529
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0019 0.0059
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0063 0.0456 0.1426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Loa Loa (eye worm) hypothetical protein 0.0426 0.3936 0.3936
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.1169 0.1358
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0983 0.1142
Loa Loa (eye worm) hypothetical protein 0.0068 0.0506 0.0506
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0157
Brugia malayi MH2 domain containing protein 0.012 0.0999 0.0999
Plasmodium vivax hypothetical protein, conserved 0.0168 0.1464 0.1603
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0019 0.0059
Brugia malayi Probable ClpP-like protease 0.009 0.0715 0.0715
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0053 0.0052
Trypanosoma brucei glucose transporter 1E 0.0071 0.0528 0.1655
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0063 0.0456 0.1426
Echinococcus granulosus calcium dependent protein kinase 0.0065 0.0478 0.0556
Trypanosoma brucei Metacaspase-4 0.0168 0.1464 0.459
Loa Loa (eye worm) hypothetical protein 0.0029 0.0128 0.0127
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Schistosoma mansoni caspase-7 (C14 family) 0.0326 0.2978 0.3463
Leishmania major hypothetical protein, conserved 0.0032 0.0158 0.0493
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0059 0.0417 0.2425
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0092 0.0733 0.0852
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0015 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.1169 0.1358
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0063 0.0456 0.1426
Loa Loa (eye worm) hypothetical protein 0.009 0.0715 0.0714
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0912 0.8597 0.8597
Echinococcus multilocularis neutral alpha glucosidase AB 0.0078 0.0596 0.0693
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0036 0.0031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.1169 0.1358
Schistosoma mansoni lysyl-tRNA synthetase 0.0051 0.0338 0.0393
Trichomonas vaginalis glucosylceramidase, putative 0.1059 1 1
Echinococcus granulosus chromobox protein 1 0.0067 0.0497 0.0577
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0109 0.0896 0.1042
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0157
Trichomonas vaginalis glucosylceramidase, putative 0.0695 0.651 0.6508
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0036 0.0041
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.007 0.0525 0.087
Loa Loa (eye worm) hypothetical protein 0.0087 0.0685 0.0684
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0525 0.052
Loa Loa (eye worm) hypothetical protein 0.0087 0.0685 0.0684
Schistosoma mansoni sugar transporter 0.0032 0.0158 0.0183
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.008 0.0615 0.1926
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0414 0.0481
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Brugia malayi jmjC domain containing protein 0.0016 0.0001 0.0001
Schistosoma mansoni ap endonuclease 0.0019 0.0035 0.004
Echinococcus granulosus importin 5 0.0016 0.0005 0.0005
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0168 0.1464 0.146
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0414 0.0481
Brugia malayi Latrophilin receptor protein 2 0.0097 0.0784 0.0784
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.007 0.0525 0.0574
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0019 0.0059
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.009 0.0715 0.0782
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0019 0.0059
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0063 0.0453 0.0453
Trichomonas vaginalis glucose transporter, putative 0.0071 0.0528 0.0523
Echinococcus granulosus muscleblind protein 0.0159 0.1373 0.1596
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0035 0.0035
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0083 0.0257
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0063 0.0453 0.142
Onchocerca volvulus 0.0032 0.0158 0.0045
Echinococcus multilocularis caspase 8 0.0168 0.1464 0.1703
Echinococcus granulosus peptidase Clp S14 family 0.0059 0.0417 0.0484
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0083 0.0077
Schistosoma mansoni glutaminase 0.027 0.2438 0.2835
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0111
Echinococcus granulosus zinc finger protein 0.0026 0.0101 0.0117
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0596 0.0591
Loa Loa (eye worm) hypothetical protein 0.007 0.0525 0.0524
Echinococcus granulosus geminin 0.0866 0.8156 0.9487
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0032 0.0158 0.0183
Trypanosoma brucei glucose transporter, putative 0.0071 0.0528 0.1655
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0128 0.1082 0.1258
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0213 0.0208
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0269 0.0293
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.009 0.0715 0.0831
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1169 0.1358
Loa Loa (eye worm) hypothetical protein 0.0049 0.0323 0.0322
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0111
Brugia malayi Calcitonin receptor-like protein seb-1 0.0308 0.2802 0.2802
Loa Loa (eye worm) hypothetical protein 0.0068 0.0506 0.0506
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0019 0.0022
Trypanosoma brucei importin beta-1 subunit, putative 0.0085 0.067 0.2098
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0193 0.0602
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0032 0.0158 0.18
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0168 0.1464 0.1464
Schistosoma mansoni hypothetical protein 0.0396 0.3646 0.424
Schistosoma mansoni hypothetical protein 0.0097 0.0784 0.0912
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0193 0.2312
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0019 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.1059 1 1
Entamoeba histolytica protein kinase, putative 0.007 0.0525 0.8792
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0157 0.077
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Entamoeba histolytica protein kinase, putative 0.007 0.0525 0.8792
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0193 0.0654
Trypanosoma brucei glycosyl hydrolase-like protein 0.0029 0.0128 0.04
Mycobacterium ulcerans glutaminase 0.027 0.2438 1
Echinococcus multilocularis dna polymerase eta 0.0019 0.0036 0.0041
Schistosoma mansoni glucose transporter 0.0032 0.0158 0.0183
Giardia lamblia Lysyl-tRNA synthetase 0.0051 0.0338 0.6551
Trypanosoma brucei glucosidase, putative 0.0078 0.0596 0.1867
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0596 0.0591
Echinococcus granulosus GTP binding nuclear protein Ran 0.0063 0.0453 0.0527
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.032 0.1001
Trichomonas vaginalis conserved hypothetical protein 0.0168 0.1464 0.146
Brugia malayi jmjC domain containing protein 0.0016 0.0001 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0456 0.045
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0032 0.0158 0.0183
Brugia malayi hypothetical protein 0.0511 0.4747 0.4747
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0148 0.0162
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0351 0.3211 0.3211
Echinococcus multilocularis muscleblind protein 0.0159 0.1373 0.1596
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0019 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0077 0.0072
Toxoplasma gondii HEAT repeat-containing protein 0.0016 0.0005 0.0008
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0069 0.0515 0.051
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.1218 0.1218
Giardia lamblia Kinase, CMGC MAPK 0.0063 0.0456 0.896
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.6242 0.7261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.008 0.0615 0.1926
Brugia malayi PHD-finger family protein 0.0032 0.0153 0.0153
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0158 0.0158
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.007 0.0525 0.0524
Onchocerca volvulus 0.0103 0.0839 0.1069
Echinococcus multilocularis chromobox protein 1 0.0067 0.0497 0.0577
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0076 0.058 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Trypanosoma cruzi metacaspase 5, putative 0.0168 0.1464 0.459
Loa Loa (eye worm) runx1 0.0064 0.0465 0.0464
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0076 0.058 0.0674
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0193 0.0602
Loa Loa (eye worm) sugar transporter 0.0032 0.0158 0.0157
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0069 0.0515 0.051
Echinococcus granulosus histone lysine methyltransferase setb 0.0109 0.0896 0.1042
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0525 0.061
Leishmania major importin beta-1 subunit, putative 0.0069 0.0515 0.1612
Trichomonas vaginalis chromobox protein, putative 0.0041 0.024 0.0235
Entamoeba histolytica hypothetical protein 0.0024 0.0083 0.1306
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0128 0.1082 0.1082
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0228 0.2036 0.2368
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0076 0.058 0.973
Trichomonas vaginalis glucosylceramidase, putative 0.1059 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0014 0.0015
Echinococcus granulosus snurportin 1 0.0912 0.8597 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0019 0.0019
Trypanosoma cruzi sugar transporter, putative 0.0032 0.0158 0.0493
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0083 0.0257
Echinococcus multilocularis muscleblind protein 1 0.0159 0.1373 0.1596
Brugia malayi hypothetical protein 0.0032 0.0158 0.0158
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0273 0.0317
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0385 0.0385
Plasmodium falciparum metacaspase 1 0.0168 0.1464 0.1603
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0158 0.0152
Echinococcus granulosus mitogen activated protein kinase 3 0.0063 0.0456 0.0529
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0157 0.0148
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0414 0.0481
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0035 0.0329
Schistosoma mansoni protein kinase 0.007 0.0525 0.061
Brugia malayi hypothetical protein 0.0258 0.2322 0.2322
Brugia malayi Glycosyl hydrolases family 31 protein 0.0029 0.0128 0.0128
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0525 0.061
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0029 0.0128 0.2079
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0213 0.0232
Loa Loa (eye worm) major facilitator superfamily transporter 0.0032 0.0158 0.0157
Toxoplasma gondii hypothetical protein 0.0031 0.0148 0.0245
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0036 0.0041
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0414 0.0481
Schistosoma mansoni alpha-glucosidase 0.0302 0.2743 0.319
Plasmodium falciparum calcium-dependent protein kinase 1 0.007 0.0525 0.0574
Echinococcus granulosus dna polymerase kappa 0.0019 0.0036 0.0041
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0032 0.0158 0.0509
Onchocerca volvulus 0.0032 0.0158 0.0045
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0068 0.0506 0.0588
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0158 0.0152
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0068 0.0506 0.6315
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Brugia malayi jmjC domain containing protein 0.0064 0.0463 0.0463
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0228 0.2036 0.2368
Trypanosoma brucei sugar transporter, putative 0.0032 0.0158 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0045 0.0278 0.0273
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0128 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Trypanosoma brucei metacaspase 0.0168 0.1464 0.459
Echinococcus granulosus General substrate transporter 0.0196 0.1729 0.201
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0048 0.0047
Schistosoma mansoni glucose transport protein 0.0228 0.2036 0.2368
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0036 0.0111
Plasmodium falciparum metacaspase-like protein 0.0168 0.1464 0.1603
Trypanosoma cruzi metacaspase 5, putative 0.0168 0.1464 0.459
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0168 0.1464 0.2427
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0063 0.0456 0.1426
Echinococcus multilocularis transportin 1 0.0016 0.0005 0.0005
Brugia malayi major facilitator superfamily protein 0.0032 0.0158 0.0158
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0063 0.0456 0.1426
Leishmania major glucose transporter, lmgt1 0.0071 0.0528 0.1655
Schistosoma mansoni chromobox protein 0.0067 0.0497 0.0577
Brugia malayi MAP kinase sur-1 0.0063 0.0456 0.0456
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0213 0.0127
Loa Loa (eye worm) hypothetical protein 0.003 0.0135 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Echinococcus multilocularis mitogen activated protein kinase 0.0063 0.0456 0.0529
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0051 0.0338 0.1261
Loa Loa (eye worm) major facilitator superfamily transporter 0.0032 0.0158 0.0157
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0068 0.0506 0.0588
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0157
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.032 0.1001
Echinococcus granulosus caspase 2 0.0426 0.3936 0.4578
Trypanosoma cruzi hexose transporter, putative 0.0071 0.0528 0.1655
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0063 0.0456 0.0455
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0193 0.0318
Schistosoma mansoni hypothetical protein 0.0021 0.0048 0.0055
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0032 0.0158 0.0493
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0083 0.0095
Echinococcus granulosus apoptotic protease activating factor 1 0.0258 0.2322 0.27
Schistosoma mansoni peptidase Clp (S14 family) 0.009 0.0715 0.0831
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0128 0.0123
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0269 0.0444
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0168 0.1464 0.2427
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0733 0.0852
Trypanosoma cruzi metacaspase, putative 0.0168 0.1464 0.459
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.1017 0.1182
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0063 0.0453 0.142
Schistosoma mansoni cpg binding protein 0.0061 0.0434 0.0504
Plasmodium vivax transportin, putative 0.0016 0.0005 0.0005
Treponema pallidum prolyl-tRNA synthetase 0.0024 0.0082 0.0686
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0076 0.058 0.1817
Loa Loa (eye worm) sugar transporter 0.0228 0.2036 0.2036
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0111
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0118 0.0983 0.1142
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.319 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0015 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0111
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0063 0.0453 0.0496
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0497 0.0492
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0157
Chlamydia trachomatis lysine--tRNA ligase 0.0051 0.0338 0.4048
Leishmania major glycosyl hydrolase-like protein 0.0029 0.0128 0.04
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0078 0.0596 1
Loa Loa (eye worm) hypothetical protein 0.0168 0.1464 0.1464
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0951 0.1577
Brugia malayi Inositol-1 0.0036 0.0193 0.0193
Brugia malayi Pre-SET motif family protein 0.0092 0.0733 0.0733
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.008 0.0615 0.1926
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Plasmodium falciparum lysine--tRNA ligase 0.0051 0.0338 0.037
Giardia lamblia Sugar-proton symporter 0.0032 0.0158 0.2842
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0078 0.0596 0.0596
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0079 0.0606 0.0704
Trypanosoma cruzi importin beta-1 subunit, putative 0.0069 0.0515 0.1612
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0019 0.0019
Echinococcus multilocularis importin subunit beta 1 0.0085 0.067 0.0778
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0051 0.0338 0.3353
Toxoplasma gondii HEAT repeat-containing protein 0.0085 0.067 0.1109
Trypanosoma cruzi metacaspase, putative 0.0168 0.1464 0.459
Schistosoma mansoni hypothetical protein 0.0097 0.0784 0.0912
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.058 0.1817
Trichomonas vaginalis sucrase-isomaltase, putative 0.0078 0.0596 0.0591
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0413 0.0479
Trypanosoma brucei protein kinase, putative 0.0063 0.0456 0.1426
Brugia malayi hypothetical protein 0.0032 0.0158 0.0158
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0032 0.0158 0.0172
Echinococcus multilocularis solute carrier family 22 0.0032 0.0158 0.0183
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0043 0.0265 0.2055
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0036 0.0004
Trypanosoma brucei THT1 - hexose transporter, putative 0.0071 0.0528 0.1655
Mycobacterium tuberculosis Conserved hypothetical protein 0.0183 0.1609 1
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0064 0.0064
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0369 0.3388 0.3709
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0128 0.1082 0.3392
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0036 0.0111
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Brugia malayi follicle stimulating hormone receptor 0.0505 0.4693 0.4693
Plasmodium vivax metacaspase 1, putative 0.0168 0.1464 0.1603
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0168 0.1464 0.146
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0059 0.0417 0.4744
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.005 0.0155
Echinococcus granulosus GPCR family 2 0.0097 0.0784 0.0912
Onchocerca volvulus 0.0032 0.0158 0.0045
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0068 0.0506 0.0588
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0068 0.0506 0.0501
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.007 0.0525 0.0525
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0168 0.1464 0.146
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0077 0.0072
Mycobacterium ulcerans integral membrane transport protein 0.0032 0.0158 0.0509
Brugia malayi latrophilin 2 splice variant baaae 0.021 0.1868 0.1868
Trichomonas vaginalis maltase-glucoamylase, putative 0.0078 0.0596 0.0591
Trichomonas vaginalis set domain proteins, putative 0.0722 0.6773 0.6771
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Trichomonas vaginalis glucosylceramidase, putative 0.0732 0.6868 0.6867
Brugia malayi Bromodomain containing protein 0.0082 0.0633 0.0633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0193 0.0187
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0228 0.2036 0.2368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0019 0.0059
Schistosoma mansoni alpha glucosidase 0.0078 0.0596 0.0693
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0019 0.0022
Echinococcus multilocularis solute carrier family 22 0.0032 0.0158 0.0183
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.1169 0.1358
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0456 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.002 0.006
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0019 0.0059
Loa Loa (eye worm) hypothetical protein 0.0038 0.0218 0.0217
Toxoplasma gondii facilitative glucose transporter GT1 0.0228 0.2036 0.3375
Trichomonas vaginalis glutaminase, putative 0.027 0.2438 0.2434
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0158 0.0152
Onchocerca volvulus 0.0032 0.0158 0.0045
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0213 0.3976
Loa Loa (eye worm) hypothetical protein 0.021 0.1868 0.1868
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0012 0.0007
Echinococcus multilocularis mitogen activated protein kinase 3 0.0063 0.0456 0.0529
Schistosoma mansoni hypothetical protein 0.0228 0.2036 0.2368
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0068 0.0506 0.0506
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0193 0.0602
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0463 0.0538
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0158 0.0152
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0525 0.061
Toxoplasma gondii HEAT repeat-containing protein 0.0016 0.0005 0.0008
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0128 0.1082 0.6652
Echinococcus granulosus lysyl tRNA synthetase 0.0051 0.0338 0.0393
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0078 0.0596 0.0987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Schistosoma mansoni bromodomain containing protein 0.007 0.052 0.0604
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0097 0.0784 0.0912
Toxoplasma gondii exonuclease III APE 0.0019 0.0035 0.0058
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0128 0.0123
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.009 0.0715 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0596 0.0591
Brugia malayi jmjC domain containing protein 0.0059 0.0414 0.0414
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Plasmodium falciparum protein kinase 7 0.0645 0.6031 0.6604
Brugia malayi Cam kinase protein 1 0.007 0.0525 0.0525
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.008 0.0615 0.1018
Giardia lamblia Hexose transporter 0.0032 0.0158 0.2842
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0063 0.0456 0.1426
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0128 0.1082 0.1258
Loa Loa (eye worm) hypothetical protein 0.0051 0.0338 0.0338
Schistosoma mansoni hypothetical protein 0.0912 0.8597 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.007 0.0525 0.0574
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0036 0.0111
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0048 0.0055
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Trypanosoma brucei importin beta-1 subunit, putative 0.0085 0.067 0.2098
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0486 0.0564
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0456 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Trypanosoma brucei glucose transporter, putative 0.0071 0.0528 0.1655
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0413 0.2398
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0019 0.0059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0109 0.0896 0.1042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0413 0.1571
Trypanosoma cruzi hexose transporter 0.0071 0.0528 0.1655
Echinococcus granulosus caspase 0.0326 0.2978 0.3463
Loa Loa (eye worm) hypothetical protein 0.0511 0.4747 0.4747
Leishmania major glucose transporter, lmgt2 0.0071 0.0528 0.1655
Plasmodium vivax CDK-related protein kinase 6, putative 0.0968 0.9133 1
Trichomonas vaginalis glucosylceramidase, putative 0.0732 0.6868 0.6867
Plasmodium falciparum calcium-dependent protein kinase 5 0.007 0.0525 0.0574
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0168 0.1464 0.146
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0157
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.009 0.0715 0.1185
Trypanosoma cruzi metacaspase, putative 0.0168 0.1464 0.459
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Echinococcus multilocularis Protein lozenge 0.0064 0.0465 0.054
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0596 0.1867
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0158 0.0152
Trypanosoma cruzi hexose transporter, putative 0.0071 0.0528 0.1655
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0128 0.0123
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0195 0.0226
Schistosoma mansoni hypothetical protein 0.0866 0.8156 0.9487
Schistosoma mansoni caspase-3 (C14 family) 0.0326 0.2978 0.3463
Echinococcus multilocularis calcium dependent protein kinase 0.0065 0.0478 0.0556
Brugia malayi Importin beta-1 subunit 0.0085 0.067 0.067
Echinococcus granulosus chromobox protein 1 0.0067 0.0497 0.0577
Trichomonas vaginalis conserved hypothetical protein 0.0228 0.2036 0.2032
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0193 0.0223
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0005 0.0005
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0068 0.0506 0.0588
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0019 0.0059
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0193 0.0223
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.319 1
Brugia malayi Heterochromatin protein 1 0.0067 0.0497 0.0497
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0019 0.0022
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0168 0.1464 0.1703
Schistosoma mansoni hypothetical protein 0.0866 0.8156 0.9487

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 14.3 uM Cytotoxicity against human K562 cells after 72 hrs by MTS assay ChEMBL. 20471276
Inhibition (binding) = 14 % Inhibition of human recombinant topoisomerase 2 alpha assessed as stabilization of enzyme-PBR322 DNA complex at 100 uM relative to control ChEMBL. 20471276
Inhibition (binding) = 56 % Inhibition of human recombinant topoisomerase 2 alpha-mediated Crithidia fasciculate kDNA decatenation at 20 uM relative to control ChEMBL. 20471276
Inhibition (binding) = 70 % Inhibition of topoisomerase 1-mediated relaxation of supercoiled pBR322 DNA at 20 uM after 20 mins using ethidium bromide staining by electrophoresis relative to control ChEMBL. 20471276

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 20471276

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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