Detailed information for compound 1167085

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 229.66 | Formula: C10H12ClNO3
  • H donors: 2 H acceptors: 2 LogP: 1.82 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1cc(Cl)c(c(c1)CN)O
  • InChi: 1S/C10H12ClNO3/c1-2-15-10(14)6-3-7(5-12)9(13)8(11)4-6/h3-4,13H,2,5,12H2,1H3
  • InChiKey: OPMLPYFQGFNFIX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0058 0.0137
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0053 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0058 0.0137
Echinococcus multilocularis traf and tnf receptor associated protein 0.0016 0.0024 0.0023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0053 0.0121
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0021 0.0055 0.0127
Loa Loa (eye worm) hypothetical protein 0.0079 0.0383 0.0567
Echinococcus multilocularis Smad4 0.0019 0.0039 0.0038
Schistosoma mansoni hypothetical protein 0.0064 0.0296 0.0327
Trichomonas vaginalis mercuric reductase, putative 0.0021 0.0053 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0058 0.0137
Entamoeba histolytica hypothetical protein 0.0051 0.0222 0.324
Loa Loa (eye worm) hypothetical protein 0.0039 0.0153 0.0227
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.002 0.0048 0.0959
Loa Loa (eye worm) oxidoreductase 0.0039 0.0153 0.0227
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0039 0.0153 0.0182
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0016 0.0024 0.0141
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0153 0.1592
Echinococcus granulosus thioredoxin glutathione reductase 0.0061 0.0279 0.0309
Trypanosoma brucei trypanothione reductase 0.0061 0.0279 0.1138
Brugia malayi AMP-binding enzyme family protein 0.0039 0.0153 0.0182
Loa Loa (eye worm) hypothetical protein 0.0132 0.0683 0.1011
Loa Loa (eye worm) hypothetical protein 0.0099 0.0493 0.073
Brugia malayi AMP-binding enzyme family protein 0.0132 0.0683 0.0812
Echinococcus granulosus histone lysine methyltransferase setb 0.0097 0.0482 0.0533
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0016 0.0024 0.0341
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0347 0.2106
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0058 0.0058
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0058 0.0064
Loa Loa (eye worm) hypothetical protein 0.0376 0.2067 0.3062
Loa Loa (eye worm) histone methyltransferase 0.0033 0.0123 0.0182
Brugia malayi F/Y-rich N-terminus family protein 0.0043 0.0178 0.0211
Loa Loa (eye worm) transcription factor SMAD2 0.0273 0.1484 0.2198
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0021 0.0053 0.1068
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0039 0.0153 0.1592
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0024 0.0472
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0016 0.0024 0.0056
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0039 0.0153 0.1592
Schistosoma mansoni smad1 5 8 and 0.0019 0.0039 0.0042
Brugia malayi MH1 domain containing protein 0.0019 0.0039 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0058 0.0137
Loa Loa (eye worm) acetyltransferase 0.0149 0.078 0.1155
Onchocerca volvulus 0.0039 0.0153 0.031
Loa Loa (eye worm) hypothetical protein 0.0064 0.03 0.0443
Echinococcus multilocularis thioredoxin glutathione reductase 0.0061 0.0279 0.0279
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0024 0.0341
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0132 0.0683 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0058 0.0064
Loa Loa (eye worm) hypothetical protein 0.0031 0.0108 0.0159
Brugia malayi Calcitonin receptor-like protein seb-1 0.0202 0.1078 0.1283
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0016 0.0024 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0153 0.1592
Schistosoma mansoni microtubule-associated protein tau 0.1602 0.9032 1
Echinococcus multilocularis peregrin 0.0034 0.0129 0.0128
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0024 0.0028
Echinococcus multilocularis synaptojanin 1 0.0016 0.0024 0.0023
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0033 0.0123 0.0343
Loa Loa (eye worm) hypothetical protein 0.0048 0.0207 0.0306
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0058 0.0058
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0024 0.0034
Schistosoma mansoni ap endonuclease 0.0064 0.0299 0.0331
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0399 0.1547
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0039 0.0153 0.0534
Trichomonas vaginalis set domain proteins, putative 0.0752 0.4206 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0064 0.0299 0.0331
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0099 0.0493 0.1628
Echinococcus multilocularis snurportin 1 0.0668 0.373 0.373
Plasmodium vivax importin-beta 2, putative 0.0063 0.0289 0.585
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0058 0.0064
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0058 0.0086
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0668 0.373 0.5526
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0058 0.0058
Loa Loa (eye worm) MH2 domain-containing protein 0.0273 0.1484 0.2198
Trichomonas vaginalis ap endonuclease, putative 0.0064 0.0299 0.0711
Plasmodium vivax SET domain protein, putative 0.0097 0.0482 0.9772
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0021 0.0053 0.0063
Brugia malayi jmjC domain containing protein 0.0101 0.0506 0.0601
Brugia malayi jmjC domain containing protein 0.0043 0.0176 0.0209
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0341
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0222 0.0527
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0039 0.0153 0.0534
Plasmodium vivax acetyl-CoA synthetase, putative 0.0039 0.0153 0.3101
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0039 0.0153 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0058 0.0069
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0399 0.8085
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0296 0.0437
Loa Loa (eye worm) hypothetical protein 0.0099 0.0493 0.073
Mycobacterium ulcerans hypothetical protein 0.0082 0.0399 0.5492
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0058 0.0137
Loa Loa (eye worm) hypothetical protein 0.0138 0.0716 0.106
Leishmania major hypothetical protein, conserved 0.0301 0.1644 1
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.078 0.0927
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0296 0.0295
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0347 0.0383
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0229
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.0195 0.6216
Trichomonas vaginalis penicillin-binding protein, putative 0.0082 0.0399 0.0949
Echinococcus granulosus neutral sphingomyelinase 0.0016 0.0024 0.0026
Leishmania major 4-coumarate:coa ligase-like protein 0.0132 0.0683 0.4153
Loa Loa (eye worm) hypothetical protein 0.12 0.6749 1
Echinococcus granulosus snurportin 1 0.0668 0.373 0.4129
Loa Loa (eye worm) hypothetical protein 0.0132 0.0683 0.1011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0086
Onchocerca volvulus 0.0082 0.0399 0.0897
Onchocerca volvulus 0.0132 0.0683 0.1576
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.002 0.0048 0.0056
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0048 0.0207 0.0207
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0064 0.0299 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0347 0.466
Loa Loa (eye worm) hypothetical protein 0.0325 0.178 0.2637
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.0222 0.0816
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0399 0.0949
Schistosoma mansoni coup transcription factor 0.0022 0.0058 0.0064
Loa Loa (eye worm) CXXC zinc finger family protein 0.0097 0.0483 0.0715
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0021 0.0053 0.0058
Leishmania major RNA-editing complex protein MP100, putative 0.0016 0.0024 0.0141
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0161 0.5
Plasmodium vivax acyl-CoA synthetase, putative 0.0099 0.0493 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.178 0.2637
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0463 0.1522
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0039 0.0153 0.1592
Mycobacterium ulcerans hypothetical protein 0.0132 0.0683 1
Onchocerca volvulus 0.0022 0.0058 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0399 0.1547
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0035 0.0134 0.0148
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0024 0.0034
Onchocerca volvulus 0.0039 0.0153 0.031
Plasmodium falciparum glutathione reductase 0.0021 0.0053 0.1068
Echinococcus multilocularis microtubule associated protein 2 0.1602 0.9032 0.9032
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0053 0.0215
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0341
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0209 0.1119 0.1238
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0039 0.0153 0.0227
Echinococcus multilocularis mothers against decapentaplegic 5 0.0019 0.0039 0.0038
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0058 0.0064
Echinococcus granulosus geminin 0.0545 0.3027 0.3351
Toxoplasma gondii thioredoxin reductase 0.0061 0.0279 0.2747
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0099 0.0493 0.6991
Onchocerca volvulus 0.0064 0.03 0.0659
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0195 0.0706
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0039 0.0153 0.1592
Loa Loa (eye worm) beta-lactamase 0.0082 0.0399 0.0591
Leishmania major acetyl-CoA synthetase, putative 0.0039 0.0153 0.093
Schistosoma mansoni ap endonuclease 0.0064 0.0299 0.0331
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0053 0.0121
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0347 0.466
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0058 0.0069
Onchocerca volvulus 0.0097 0.0482 0.1096
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0034
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0058 0.0064
Mycobacterium tuberculosis Probable lipase LipD 0.0082 0.0399 0.1301
Leishmania major trypanothione reductase 0.0061 0.0279 0.1696
Schistosoma mansoni hypothetical protein 0.0064 0.0296 0.0327
Toxoplasma gondii HEAT repeat-containing protein 0.0063 0.0289 0.2843
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0053 0.0215
Schistosoma mansoni inositol 145-trisphosphate receptor 0.1342 0.7555 0.8365
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0064 0.0299 0.4377
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0058 0.0064
Echinococcus granulosus traf and tnf receptor associated protein 0.0016 0.0024 0.0026
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0443 0.245 1
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0016 0.0024 0.0474
Leishmania major GTP-binding protein, putative 0.0046 0.0195 0.1183
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0296 0.0327
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0021 0.0025
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0039 0.0153 0.3101
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0039 0.0153 0.1507
Brugia malayi MH2 domain containing protein 0.0019 0.0039 0.0046
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0024 0.007 0.0102
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0089 0.0089
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0132 0.0683 1
Echinococcus multilocularis dnaJ subfamily B 0.1378 0.7761 0.7761
Echinococcus granulosus importin subunit beta 1 0.0063 0.0289 0.0319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0058 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0058 0.0137
Leishmania major hypothetical protein, conserved 0.0016 0.0024 0.0141
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0229
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0058 0.0137
Trypanosoma cruzi trypanothione reductase, putative 0.0021 0.0053 0.0121
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0058 0.0064
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0024 0.0026
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0088 0.0431 0.0477
Onchocerca volvulus 0.0752 0.4206 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0058 0.0058
Trichomonas vaginalis esterase, putative 0.0082 0.0399 0.0949
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0053 0.032
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0021 0.0055 0.008
Brugia malayi RNA, U transporter 1 0.0178 0.0945 0.1123
Mycobacterium tuberculosis Probable hydrolase 0.0082 0.0399 0.1301
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.1038 0.1149
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0082 0.0399 0.0474
Entamoeba histolytica Ran family GTPase 0.0046 0.0195 0.2849
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0058 0.0137
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0039 0.0153 0.0534
Entamoeba histolytica hypothetical protein 0.0035 0.0132 0.1925
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0024 0.0028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0058 0.0137
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0058 0.0137
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0153 0.1592
Echinococcus granulosus beta LACTamase domain containing family member 0.0082 0.0399 0.0441
Schistosoma mansoni inositol 145-trisphosphate receptor 0.1116 0.6271 0.6943
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0039 0.0153 0.093
Loa Loa (eye worm) glutathione reductase 0.0061 0.0279 0.0413
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0039 0.0153 0.0449
Entamoeba histolytica acyl-CoA synthetase, putative 0.0132 0.0683 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0132 0.0683 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.0195 0.0794
Mycobacterium ulcerans acyl-CoA synthetase 0.0132 0.0683 1
Schistosoma mansoni hypothetical protein 0.0545 0.3027 0.3351
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0132 0.0683 1
Echinococcus granulosus ryanodine receptor 44f 0.0292 0.1589 0.1759
Brugia malayi CXXC zinc finger family protein 0.0097 0.0483 0.0574
Brugia malayi beta-lactamase family protein 0.0082 0.0399 0.0474
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0039 0.0153 0.0449
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0182 0.0433
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0482 0.0533
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0064 0.0299 0.1135
Schistosoma mansoni ran 0.0046 0.0195 0.0215
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0021 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0132 0.0683 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0082 0.0399 0.1301
Mycobacterium tuberculosis Conserved protein 0.0082 0.0399 0.1301
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0028 0.0089 0.0089
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0082 0.0399 0.5492
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0053 0.0121
Mycobacterium tuberculosis Probable lipase LipE 0.0082 0.0399 0.1301
Loa Loa (eye worm) Plcb4 protein 0.0047 0.02 0.0296
Brugia malayi MIR domain containing protein 0.0082 0.0401 0.0476
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0294 0.0435
Brugia malayi exodeoxyribonuclease III family protein 0.0064 0.0299 0.0355
Schistosoma mansoni synaptojanin 0.0016 0.0024 0.0026
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0021 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0099 0.0493 0.073
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0182 0.0201
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0024 0.0095
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0097 0.0482 0.0482
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0024 0.0474
Trichomonas vaginalis ran, putative 0.0046 0.0195 0.0463
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0016 0.0024 0.0056
Mycobacterium tuberculosis Probable esterase LipL 0.0082 0.0399 0.1301
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0132 0.0683 0.2285
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0506 0.056
Echinococcus granulosus smad 0.0019 0.0039 0.0042
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0016 0.0024 0.0095
Plasmodium falciparum importin beta, putative 0.0063 0.0289 0.585
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0034
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0016 0.0024 0.0056
Schistosoma mansoni hypothetical protein 0.0668 0.373 0.4129
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0058 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0058 0.0137
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0347 0.0346
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0021 0.0055 0.0534
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0341
Loa Loa (eye worm) hypothetical protein 0.0053 0.0233 0.0344
Onchocerca volvulus 0.0059 0.027 0.0589
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.0716 0.0851
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0524 0.2909 1
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0016 0.0024 0.0472
Echinococcus multilocularis beta LACTamase domain containing family member 0.0082 0.0399 0.0399
Plasmodium vivax exodeoxyribonuclease III, putative 0.0016 0.0024 0.0472
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0058 0.0058
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0145 0.0144
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0058 0.0064
Loa Loa (eye worm) hypothetical protein 0.0202 0.1078 0.1597
Onchocerca volvulus 0.0039 0.0153 0.031
Loa Loa (eye worm) hypothetical protein 0.0063 0.0289 0.0427
Echinococcus granulosus tumor protein p63 0.0405 0.2234 0.2473
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0021 0.0053 0.0102
Trichomonas vaginalis Phospholipase C precursor, putative 0.0016 0.0024 0.0056
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0058 0.0069
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0053 0.0121
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0108 0.2182
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0016 0.0024 0.0472
Schistosoma mansoni hypothetical protein 0.0064 0.0296 0.0327
Loa Loa (eye worm) MIR domain-containing protein 0.0082 0.0401 0.0593
Echinococcus granulosus Smad4 0.0019 0.0039 0.0042
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0058 0.0058
Brugia malayi beta-lactamase 0.0082 0.0399 0.0474
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0161 0.3266
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0347 0.466
Onchocerca volvulus 0.0082 0.0399 0.0897
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0039 0.0153 0.1592
Brugia malayi Bromodomain containing protein 0.0034 0.0129 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0058 0.0086
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0132 0.0683 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0482 0.0533
Trichomonas vaginalis hypothetical protein 0.0012 0 0.0001
Schistosoma mansoni hypothetical protein 0.0064 0.0296 0.0327
Brugia malayi cation channel family protein 0.1491 0.8405 1
Brugia malayi ecdysteroid receptor 0.0022 0.0058 0.0069
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0058 0.0064
Mycobacterium tuberculosis Probable oxidoreductase 0.0021 0.0053 0.0102
Schistosoma mansoni hypothetical protein 0.1378 0.7761 0.8593
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0024 0.0028
Echinococcus granulosus peregrin 0.0034 0.0129 0.0142
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0034
Echinococcus multilocularis ryanodine receptor 44f 0.0376 0.2067 0.2067
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0108 0.0119
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0058 0.0082
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0108 0.106
Brugia malayi Smad1 0.0019 0.0039 0.0046
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0341
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.1038 0.1038
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0176 0.026
Onchocerca volvulus 0.0097 0.0483 0.1098
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0039 0.0153 0.0624
Echinococcus multilocularis cpg binding protein 0.0102 0.0514 0.0514
Onchocerca volvulus 0.0048 0.0207 0.0439
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0039 0.0153 0.1592
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.1038 0.1149
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0039 0.0153 0.1592
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0058 0.0064
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0024 0.0028
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.007
Mycobacterium ulcerans esterase/lipase LipP 0.0082 0.0399 0.5492
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0525 0.2917 0.3471
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0058 0.0069
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.0756 0.0837
Loa Loa (eye worm) hypothetical protein 0.0099 0.0493 0.073
Schistosoma mansoni hypothetical protein 0.0545 0.3027 0.3351
Schistosoma mansoni cellular tumor antigen P53 0.0059 0.027 0.0298
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0153 0.0449
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0016 0.0024 0.0341
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0039 0.0153 0.1592
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.002 0.0048 0.0288
Trichomonas vaginalis helicase, putative 0.0022 0.0058 0.0137
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0089 0.0099
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.0195 0.3945
Leishmania major 4-coumarate:coa ligase-like protein 0.0132 0.0683 0.4153
Schistosoma mansoni hypothetical protein 0.0031 0.0108 0.0119
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0021 0.0055 0.0064
Brugia malayi nuclear receptor NHR-88 0.0022 0.0058 0.0069
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0058 0.0064
Trichomonas vaginalis glutathione reductase, putative 0.0021 0.0053 0.0126
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0086
Giardia lamblia NADH oxidase lateral transfer candidate 0.0021 0.0053 0.1066
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0039 0.0153 0.0449
Toxoplasma gondii exonuclease III APE 0.0064 0.0299 0.2945
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0182 0.0433
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0132 0.0131
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0024 0.0472
Entamoeba histolytica acyl-CoA synthetase, putative 0.0132 0.0683 1
Plasmodium vivax glutathione reductase, putative 0.0061 0.0279 0.5654
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0202 0.1078 0.1597
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0061 0.0279 0.0885
Echinococcus granulosus muscleblind protein 0.0325 0.178 0.1971
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0296 0.0327
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.0195 0.0215
Brugia malayi glutathione reductase 0.0061 0.0279 0.0332
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0024 0.0095
Echinococcus granulosus ryanodine receptor 44f 0.0376 0.2067 0.2288
Echinococcus granulosus microtubule associated protein 2 0.1602 0.9032 1
Leishmania major inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0079 0.0383 0.2329
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0194 0.1038 0.1234
Mycobacterium tuberculosis Conserved protein 0.0082 0.0399 0.1301
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0058 0.0064
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0058 0.0064
Schistosoma mansoni Smad4 0.0019 0.0039 0.0042
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.078 0.078
Loa Loa (eye worm) hypothetical protein 0.1116 0.6271 0.9292
Onchocerca volvulus Alhambra homolog 0.0031 0.0108 0.0202
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0176 0.0195
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0058 0.0069
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0039 0.0153 0.0169
Loa Loa (eye worm) hypothetical protein 0.0079 0.0383 0.0567
Brugia malayi AMP-binding enzyme family protein 0.0132 0.0683 0.0812
Leishmania major hypothetical protein, conserved 0.0016 0.0024 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0058 0.0069
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0161 0.2359
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0132 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0058 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0058 0.0069
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0058 0.0082
Leishmania major importin beta-1 subunit, putative 0.0051 0.0222 0.1345
Schistosoma mansoni hypothetical protein 0.0138 0.0716 0.0792
Loa Loa (eye worm) hypothetical protein 0.0079 0.0383 0.0567
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0399 0.0949
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0341
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0024 0.0095
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0031
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0024 0.0028
Echinococcus granulosus dnaJ subfamily B 0.1378 0.7761 0.8593
Toxoplasma gondii propionate-CoA ligase 0.0039 0.0153 0.1507
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0053 0.0121
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0176 0.0195
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0053 0.0121
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0021 0.0053 0.032
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0064 0.0299 0.606
Entamoeba histolytica acyl-coA synthetase, putative 0.0132 0.0683 1
Entamoeba histolytica hypothetical protein 0.0035 0.0132 0.1925
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0021 0.0053 0.1068
Trichomonas vaginalis importin beta-1, putative 0.0051 0.0222 0.0527
Brugia malayi beta-lactamase family protein 0.0082 0.0399 0.0474
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0229
Echinococcus multilocularis deoxyribonuclease 1 2 0.0016 0.0024 0.0023
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0341
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0099 0.0493 1
Echinococcus multilocularis neutral sphingomyelinase 0.0016 0.0024 0.0023
Trypanosoma brucei RNA editing exonuclease 2 0.0016 0.0024 0.0095
Onchocerca volvulus 0.0039 0.0153 0.031
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.0082 0.0401 0.0443
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.1038 0.1149
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.1038 0.1149
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0058 0.0058
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.0195 0.0231
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0016 0.0024 0.0023
Echinococcus granulosus cytohesin 1 0.0088 0.0431 0.0477
Schistosoma mansoni cpg binding protein 0.0102 0.0514 0.0569
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0463 0.1522
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0024 0.0056
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0108 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0058 0.0137
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0399 0.0949
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0024 0.0472
Toxoplasma gondii histone lysine methyltransferase SET1 0.019 0.1015 1
Leishmania major endonuclease/exonuclease protein-like protein 0.0016 0.0024 0.0141
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0021 0.0053 0.1068
Brugia malayi CCR4 0.0016 0.0024 0.0028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0058 0.0058
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0021 0.0053 0.0519
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0082 0.0399 0.1301
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0058 0.0137
Entamoeba histolytica hypothetical protein 0.0035 0.0132 0.1925
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0019 0.0039 0.0038
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0296 0.0351
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0058 0.0069
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0058 0.0064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0086
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0296 0.0351
Loa Loa (eye worm) ryanodine receptor 0.0142 0.0739 0.1094
Echinococcus multilocularis cytohesin 1 0.0088 0.0431 0.0431
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0058 0.0069
Echinococcus multilocularis geminin 0.0545 0.3027 0.3027
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0058 0.0069
Mycobacterium leprae conserved hypothetical protein 0.0082 0.0399 0.5492
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0039 0.0153 0.0534
Loa Loa (eye worm) hypothetical protein 0.0082 0.0399 0.0591
Echinococcus granulosus mixed lineage leukemia protein mll 0.0028 0.0089 0.0099
Brugia malayi AMP-binding enzyme family protein 0.0039 0.0153 0.0182
Echinococcus multilocularis GPCR, family 2 0.0064 0.0296 0.0295
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0347 0.1119
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0296 0.0295
Brugia malayi PHD-finger family protein 0.0016 0.0022 0.0025
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0016 0.0024 0.0095
Leishmania major 4-coumarate:coa ligase-like protein 0.0132 0.0683 0.4153
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0024 0.0034
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0058 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0058 0.0086
Schistosoma mansoni jumonji domain containing protein 0.008 0.0388 0.0429
Leishmania major hypothetical protein, conserved 0.0082 0.0399 0.2425
Loa Loa (eye worm) hypothetical protein 0.0113 0.0574 0.0849
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0021 0.0053 0.0058
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0153 0.1592
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0024 0.0141
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0016 0.0024 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0153 0.1592
Schistosoma mansoni smad1 5 8 and 0.0019 0.0039 0.0042
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0024 0.0034
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0176 0.0176
Mycobacterium ulcerans beta-lactamase 0.0082 0.0399 0.5492
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0082 0.0399 0.0591
Brugia malayi hypothetical protein 0.0035 0.0132 0.0156
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0058 0.0082
Brugia malayi Pre-SET motif family protein 0.0661 0.3689 0.4389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0058 0.0086
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0039 0.0153 0.1592
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0039 0.0153 0.1507
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0153 0.1592
Schistosoma mansoni cpg binding protein 0.0097 0.0483 0.0534
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0399 0.0441
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0021 0.0054 0.0126
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0097 0.0482 0.0533
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0202 0.1078 0.1283
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0064 0.0299 1
Onchocerca volvulus 0.0082 0.0399 0.0897
Schistosoma mansoni smad1 5 8 and 0.0019 0.0039 0.0042
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0347 0.0383
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0039 0.0057
Toxoplasma gondii NADPH-glutathione reductase 0.0021 0.0053 0.0519
Schistosoma mansoni hypothetical protein 0.0016 0.0024 0.0026
Brugia malayi phospholipase C homolog 0.0035 0.0134 0.0159
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0506 0.0505
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0058 0.0137
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0095 0.0474 0.1932
Brugia malayi Importin beta-1 subunit 0.0063 0.0289 0.0343
Schistosoma mansoni smad 0.0019 0.0039 0.0042
Trypanosoma cruzi inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0079 0.0383 0.1482
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0064 0.0299 0.0955
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0058 0.0058
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0091 0.045 0.0498
Schistosoma mansoni nocturnin 0.0016 0.0024 0.0026
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0064 0.0299 0.3907
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0058 0.0064
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0153 0.0449
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0039 0.0057
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0086
Plasmodium falciparum acyl-CoA synthetase 0.0099 0.0493 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.027 0.0399
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0229
Echinococcus multilocularis stromal cell derived factor 2 0.0082 0.0401 0.04
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0182 0.3686
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0016 0.0024 0.0472
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0086
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0024 0.0028
Plasmodium falciparum thioredoxin reductase 0.0061 0.0279 0.5654
Echinococcus multilocularis ryanodine receptor 44f 0.0292 0.1589 0.1589
Brugia malayi AMP-binding enzyme family protein 0.0039 0.0153 0.0182
Schistosoma mansoni carbon catabolite repressor protein 0.0016 0.0024 0.0026
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0053 0.0121
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0132 0.0683 0.2285
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0058 0.0064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0463 0.1522
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0047 0.02 0.0238
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0058 0.0086
Leishmania major hypothetical protein, conserved 0.0016 0.0024 0.0141
Trichomonas vaginalis mannosyltransferase 1, putative 0.0082 0.0401 0.0953
Onchocerca volvulus 0.0082 0.0401 0.0901
Echinococcus multilocularis tumor protein p63 0.0405 0.2234 0.2233
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0108 0.0159
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0039 0.0153 0.0182
Plasmodium vivax phospholipase C-like, putative 0.002 0.0048 0.0959
Leishmania major phosphoinositide-specific phospholipase C, putative 0.002 0.0048 0.0288
Echinococcus multilocularis importin subunit beta 1 0.0063 0.0289 0.0288
Entamoeba histolytica hypothetical protein 0.0035 0.0132 0.1925
Loa Loa (eye worm) hypothetical protein 0.0097 0.0482 0.0714
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0039 0.0153 0.0624
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0021 0.0053 0.032
Loa Loa (eye worm) hypothetical protein 0.0082 0.0399 0.0591
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0399 0.0441
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0064 0.0299 0.122
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0176 0.0195
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0347 0.3412
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0033 0.0123 0.0136
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0016 0.0024 0.0026
Echinococcus multilocularis smad 0.0019 0.0039 0.0038
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.0195 0.0288
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0039 0.0153 0.0153
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0182 0.1791
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0153 0.1592
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0039 0.0153 0.224
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0016 0.0024 0.0034
Plasmodium falciparum DNase I-like protein, putative 0.0016 0.0024 0.0472
Leishmania major acetyl-CoA synthetase, putative 0.0039 0.0153 0.093
Schistosoma mansoni synaptojanin 0.0016 0.0024 0.0026
Echinococcus granulosus cpg binding protein 0.0102 0.0514 0.0569
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0108 0.0108
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0016 0.0024 0.0023
Brugia malayi Pre-SET motif family protein 0.0097 0.0482 0.0573
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0024 0.0028
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0024 0.0095
Schistosoma mansoni hypothetical protein 0.0035 0.0132 0.0145
Loa Loa (eye worm) hypothetical protein 0.0039 0.0153 0.0227
Brugia malayi PHD-finger family protein 0.0031 0.0108 0.0128
Brugia malayi AMP-binding enzyme family protein 0.0132 0.0683 0.0812
Trichomonas vaginalis penicillin-binding protein, putative 0.0082 0.0399 0.0949
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0016 0.0024 0.0056
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0443 0.245 1
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0016 0.0024 0.0341
Loa Loa (eye worm) hypothetical protein 0.0082 0.0399 0.0591
Leishmania major pantothenate kinase subunit, putative 0.0021 0.0054 0.0328
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0058 0.0069
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0222 0.0527
Mycobacterium leprae Probable lipase LipE 0.0082 0.0399 0.5492
Echinococcus granulosus mothers against decapentaplegic 5 0.0019 0.0039 0.0042
Schistosoma mansoni cript-related 0.0016 0.0024 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0058 0.0069
Trypanosoma cruzi trypanothione reductase, putative 0.0061 0.0279 0.1053
Echinococcus multilocularis muscleblind protein 1 0.0325 0.178 0.178
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.1038 0.1038
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0097 0.0482 0.0482
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0153 0.1592
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0024 0.0028
Loa Loa (eye worm) hypothetical protein 0.0132 0.0683 0.1011
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0229
Echinococcus multilocularis muscleblind protein 0.0325 0.178 0.178
Treponema pallidum NADH oxidase 0.0021 0.0053 0.1066
Schistosoma mansoni cpg binding protein 0.0102 0.0514 0.0569
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0097 0.0482 0.4749
Treponema pallidum exodeoxyribonuclease (exoA) 0.0064 0.0299 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0482 0.0533
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0058 0.0064
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0132 0.0683 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.0195 0.1917
Trichomonas vaginalis ap endonuclease, putative 0.0064 0.0299 0.0711
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0048 0.0207 0.0229
Onchocerca volvulus 0.0048 0.0207 0.0439
Brugia malayi phospholipase C homolog 0.0013 0.0006 0.0007
Trichomonas vaginalis antibiotic synthetase, putative 0.0039 0.0153 0.0365
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.0147 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0058 0.0069
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0182 0.1791
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.1038 0.1149
Loa Loa (eye worm) hypothetical protein 0.0064 0.0296 0.0437
Plasmodium falciparum thioredoxin reductase 0.0021 0.0053 0.1068
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0058 0.0064
Schistosoma mansoni phospholipase C beta 0.0047 0.02 0.0221
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0039 0.0153 0.0449
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0021 0.0053 0.0215
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0024 0.0056
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0289 0.1177
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0033 0.0123 0.0123
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0064 0.0299 0.1818
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0086
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0039 0.0153 0.0449
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0108 0.106
Brugia malayi MH2 domain containing protein 0.0019 0.0039 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0058 0.0086
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0039 0.0153 0.1592
Toxoplasma gondii ABC1 family protein 0.0082 0.0399 0.3929
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0064 0.0299 0.0299
Entamoeba histolytica MIR domain protein 0.0082 0.0401 0.5865
Plasmodium falciparum phd finger protein, putative 0.0031 0.0108 0.2182
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0176 0.0195
Mycobacterium ulcerans lipase LipD 0.0082 0.0399 0.5492
Brugia malayi steroid hormone receptor 0.0022 0.0058 0.0069
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0132 0.0683 1
Echinococcus granulosus synaptojanin 1 0.0016 0.0024 0.0026
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0229
Mycobacterium tuberculosis Conserved protein 0.0082 0.0399 0.1301
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0058 0.0064
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0064 0.0299 0.1135
Schistosoma mansoni ryanodine receptor related 0.0525 0.2917 0.323
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0021 0.0021
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0064 0.0299 0.0443
Plasmodium falciparum glutathione reductase 0.0061 0.0279 0.5654
Loa Loa (eye worm) cytohesin 3 0.0088 0.0431 0.0638
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0086
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0021 0.0055 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0058 0.0069
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.078 0.0863
Loa Loa (eye worm) hypothetical protein 0.0082 0.0399 0.0591
Brugia malayi Thioredoxin reductase 0.0061 0.0279 0.0332
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0194 0.1038 0.1537
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0195 0.0706
Brugia malayi MH2 domain containing protein 0.0273 0.1484 0.1765
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0053 0.0121
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0082 0.0399 0.1301
Brugia malayi nuclear hormone receptor 0.0022 0.0058 0.0069
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0024 0.0028
Trichomonas vaginalis antibiotic synthetase, putative 0.0039 0.0153 0.0365
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0289 0.1177
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0021 0.0023
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0347 0.0383
Schistosoma mansoni ryanodine receptor 1 skeletal muscle 0.0142 0.0739 0.0818
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0039 0.0153 0.0449
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0024 0.0034
Schistosoma mansoni neutral sphingomyelinase 0.0016 0.0024 0.0026
Plasmodium vivax thioredoxin reductase, putative 0.0061 0.0279 0.5654
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0058 0.0137
Loa Loa (eye worm) Smad1 0.0019 0.0039 0.0057
Loa Loa (eye worm) hypothetical protein 0.0082 0.0399 0.0591
Brugia malayi Variant SH3 domain containing protein 0.0024 0.007 0.0082
Loa Loa (eye worm) hypothetical protein 0.119 0.6694 0.9919
Brugia malayi MH1 domain containing protein 0.0019 0.0039 0.0046
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0463 0.1522
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0153 0.0449
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0039 0.0153 0.0449
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0021 0.0053 0.1068
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0132 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0058 0.0137
Giardia lamblia PHD finger protein 15 0.0031 0.0108 0.306
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0021 0.0053 0.0102
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0024 0.0056
Echinococcus granulosus GPCR family 2 0.0064 0.0296 0.0327
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0153 0.0449
Brugia malayi AMP-binding enzyme family protein 0.0039 0.0153 0.0182
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.0195 0.0195
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0021 0.0053 0.0215
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0016 0.0024 0.0472
Loa Loa (eye worm) thioredoxin reductase 0.0061 0.0279 0.0413
Echinococcus granulosus stromal cell derived factor 2 0.0082 0.0401 0.0443
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0058 0.0069
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0661 0.3689 0.5466
Echinococcus granulosus TGF beta signal transducer SmadC 0.0019 0.0039 0.0042
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0064 0.0299 0.606
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0058 0.0069
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0077 0.0373 0.0412
Brugia malayi Cytohesin 3 0.0088 0.0431 0.0512
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0019 0.0039 0.0042
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0058 0.0137
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0021 0.0053 0.0102
Loa Loa (eye worm) hypothetical protein 0.0099 0.0493 0.073
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0024 0.0341
Trypanosoma cruzi inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0079 0.0383 0.1482
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0016 0.0024 0.0026
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.0195 0.3945
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0039 0.0153 0.1592
Trypanosoma brucei hypothetical protein, conserved 0.0082 0.0399 0.1627
Loa Loa (eye worm) hypothetical protein 0.0082 0.0399 0.0591
Schistosoma mansoni importin beta-1 0.0063 0.0289 0.0319
Schistosoma mansoni acetyl-CoA synthetase 0.0039 0.0153 0.0169
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0024 0.0023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0032 0.0035
Leishmania major phospholipase c-like protein 0.0021 0.0055 0.033
Schistosoma mansoni ran 0.0046 0.0195 0.0215
Brugia malayi Muscleblind-like protein 0.0325 0.178 0.2118
Mycobacterium ulcerans acetyl-CoA synthetase 0.0039 0.0153 0.1592

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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