Detailed information for compound 1294614

Basic information

Technical information
  • TDR Targets ID: 1294614
  • Name: N-(1-phenylethyl)-2-pyridin-4-ylquinazolin-4- amine
  • MW: 326.394 | Formula: C21H18N4
  • H donors: 1 H acceptors: 3 LogP: 4.35 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1ccccc1)Nc1nc(nc2c1cccc2)c1ccncc1
  • InChi: 1S/C21H18N4/c1-15(16-7-3-2-4-8-16)23-21-18-9-5-6-10-19(18)24-20(25-21)17-11-13-22-14-12-17/h2-15H,1H3,(H,23,24,25)
  • InChiKey: YILNAATVQIJIAT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(1-phenylethyl)-2-(4-pyridyl)quinazolin-4-amine
  • N-(1-phenylethyl)-2-(4-pyridyl)-4-quinazolinamine
  • 1-phenylethyl-[2-(4-pyridyl)quinazolin-4-yl]amine
  • N-(1-phenylethyl)-2-pyridin-4-yl-quinazolin-4-amine
  • STOCK3S-76524

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi major facilitator superfamily protein 0.0029 0.0195 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0213 0.2226 0.2226
Loa Loa (eye worm) hypothetical protein 0.0029 0.0195 0.0195
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2181 0.2316
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.0578 0.0597
Brugia malayi Sugar transporter family protein 0.0209 0.2181 0.2181
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0213 0.2226 0.2364
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0057 0.0059
Entamoeba histolytica protein kinase, putative 0.0064 0.0577 0.5014
Brugia malayi nuclear receptor NHR-67 0.01 0.0981 0.0981
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0044 0.036 0.0372
Mycobacterium leprae Probable monophosphatase 0.0012 0.0004 0.0012
Trypanosoma brucei glucose transporter, putative 0.0065 0.0587 0.177
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.036 0.1087
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0678 0.2046
Trypanosoma brucei unspecified product 0.0014 0.003 0.0089
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0587 0.177
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.003 0.0089
Echinococcus multilocularis dna polymerase eta 0.0021 0.0101 0.0108
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0301 0.032
Brugia malayi Nuclear hormone receptor-like 1 0.0213 0.2226 0.2226
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0195 0.0588
Loa Loa (eye worm) hypothetical protein 0.0051 0.0433 0.0433
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2181 0.2316
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0213 0.2226 0.2364
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0044 0.036 0.0382
Plasmodium falciparum glutathione reductase 0.0044 0.036 0.0372
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0044 0.036 0.0372
Plasmodium vivax sugar transporter, putative 0.0029 0.0195 0.0201
Loa Loa (eye worm) hypothetical protein 0.0029 0.0195 0.0195
Brugia malayi photoreceptor-specific nuclear receptor 0.0213 0.2226 0.2226
Echinococcus granulosus solute carrier family 22 0.0029 0.0195 0.0207
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0386 0.6849
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0128 0.1284 0.1294
Brugia malayi Pre-SET motif family protein 0.0207 0.2163 0.2163
Loa Loa (eye worm) beta-lactamase 0.0142 0.1443 0.1443
Brugia malayi latrophilin 2 splice variant baaae 0.0206 0.2154 0.2154
Echinococcus multilocularis pyruvate kinase 0.0017 0.0057 0.006
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0577 0.0613
Schistosoma mansoni protein kinase 0.0064 0.0577 0.0613
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0142 0.1443 0.1455
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0213 0.2226 0.2226
Loa Loa (eye worm) hypothetical protein 0.01 0.0981 0.0981
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0195 0.0207
Brugia malayi Smad1 0.0016 0.0049 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0195 0.0586
Echinococcus granulosus solute carrier family 22 0.0029 0.0195 0.0207
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0386 0.2291
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0577 0.0613
Leishmania major hypothetical protein, conserved 0.0054 0.0466 0.1406
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0587 0.177
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.016 0.0166
Mycobacterium leprae POSSIBLE MONOPHOSPHATASE CYSQ 0.0012 0.0004 0.0012
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0678 0.2046
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.046 0.1388
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0324 0.0344
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0324 0.0344
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0291 0.3096 0.312
Echinococcus granulosus pyruvate kinase 0.0017 0.0057 0.006
Brugia malayi Nuclear hormone receptor E75 0.01 0.0981 0.0981
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Trypanosoma cruzi hexose transporter 0.0065 0.0587 0.177
Loa Loa (eye worm) hypothetical protein 0.0142 0.1443 0.1443
Loa Loa (eye worm) hypothetical protein 0.0112 0.1114 0.1114
Trichomonas vaginalis mercuric reductase, putative 0.0044 0.036 0.1083
Echinococcus granulosus pyruvate kinase 0.0017 0.0057 0.006
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0525 0.0557
Schistosoma mansoni myo inositol monophosphatase 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.01 0.0981 0.0981
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0282 0.3949
Loa Loa (eye worm) hypothetical protein 0.0112 0.1114 0.1114
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0101 0.088
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0713 0.4236
Trypanosoma cruzi hypothetical protein, conserved 0.0142 0.1443 0.4356
Loa Loa (eye worm) hypothetical protein 0.0213 0.2226 0.2226
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0306
Onchocerca volvulus 0.0029 0.0195 0.0786
Trypanosoma brucei glucose transporter, putative 0.0065 0.0587 0.177
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0577 0.0613
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0324 0.0975
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.01 0.0981 0.1042
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0195 0.1157
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0525 0.1584
Brugia malayi beta-lactamase family protein 0.0142 0.1443 0.1443
Echinococcus multilocularis thyroid hormone receptor alpha 0.0213 0.2226 0.2364
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0044 0.036 0.0363
Toxoplasma gondii sugar transporter ST3 0.0029 0.0195 0.0304
Trichomonas vaginalis set domain proteins, putative 0.0235 0.2478 0.7453
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0213 0.2226 0.2364
Loa Loa (eye worm) hypothetical protein 0.01 0.0981 0.0981
Mycobacterium tuberculosis Probable hydrolase 0.0142 0.1443 0.1455
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.036 0.1087
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0302 0.3212 0.3212
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.2181 0.2316
Schistosoma mansoni hypothetical protein 0.0206 0.2154 0.2288
Loa Loa (eye worm) hypothetical protein 0.0029 0.0195 0.0195
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0566 0.0601
Loa Loa (eye worm) hypothetical protein 0.0142 0.1443 0.1443
Echinococcus granulosus inositol monophosphatase 1 0.0116 0.1152 0.1223
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0525 0.3117
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2181 0.2316
Brugia malayi Inositol-1 0.0116 0.1152 0.1152
Echinococcus granulosus nuclear receptor 2DBD gamma 0.01 0.0981 0.1042
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.01 0.0981 0.1042
Loa Loa (eye worm) hypothetical protein 0.0142 0.1443 0.1443
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0587 0.177
Loa Loa (eye worm) RNA binding protein 0.0063 0.0566 0.0566
Echinococcus multilocularis ferritin 0.0017 0.0053 0.0057
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0324 0.0344
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0234 0.0234
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0308 0.031
Entamoeba histolytica hypothetical protein 0.0047 0.0386 0.3349
Trichomonas vaginalis inositol monophosphatase, putative 0.0116 0.1152 0.3463
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0101 0.0306
Schistosoma mansoni pyruvate kinase 0.0017 0.0057 0.006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0213 0.2226 0.2226
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.036 0.1087
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0101 0.0306
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0012 0.0004 0.0037
Leishmania major DNA polymerase eta, putative 0.0021 0.0101 0.0306
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0306
Entamoeba histolytica hypothetical protein 0.0039 0.0301 0.2617
Echinococcus granulosus thyroid hormone receptor alpha 0.01 0.0981 0.1042
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0149 0.1517 0.1517
Schistosoma mansoni cpg binding protein 0.0028 0.0183 0.0195
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0587 0.1764
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0713 0.4236
Schistosoma mansoni hypothetical protein 0.0095 0.0927 0.0985
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0282 0.085
Plasmodium vivax proline--tRNA ligase, putative 0.0073 0.0678 0.0701
Toxoplasma gondii sugar transporter ST2 0.0029 0.0195 0.0304
Schistosoma mansoni steroid hormone receptor ad4bp 0.0213 0.2226 0.2364
Echinococcus multilocularis FTZ F1 alpha 0.0213 0.2226 0.2364
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0044 0.036 0.2138
Plasmodium falciparum mitogen-activated protein kinase 2 0.0337 0.3604 0.3724
Onchocerca volvulus 0.01 0.0981 0.3959
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.4332 0.4602
Schistosoma mansoni cpg binding protein 0.003 0.0201 0.0214
Echinococcus granulosus smad 0.0016 0.0049 0.0052
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0587 0.177
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0213 0.2226 0.2226
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0678 0.2046
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0044 0.036 0.1087
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0282 0.0291
Trypanosoma brucei glucose transporter 1E 0.0065 0.0587 0.177
Loa Loa (eye worm) hypothetical protein 0.0076 0.0713 0.0713
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0053 0.0749
Onchocerca volvulus 0.0142 0.1443 0.5824
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0525 0.3117
Trichomonas vaginalis penicillin-binding protein, putative 0.0142 0.1443 0.434
Schistosoma mansoni hypothetical protein 0.0095 0.0927 0.0985
Echinococcus granulosus nuclear receptor nhr 48 0.01 0.0981 0.1042
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0101 0.0602
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0195 0.0586
Trypanosoma brucei unspecified product 0.0014 0.003 0.0089
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0115 0.1609
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0386 0.0386
Brugia malayi hypothetical protein 0.0029 0.0195 0.0195
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0213 0.2226 0.2364
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0213 0.2226 0.2226
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0234 0.1389
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0282 0.1673
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0386 0.0399
Giardia lamblia DINP protein human, muc B family 0.0021 0.0101 0.18
Onchocerca volvulus Protein ultraspiracle homolog 0.0213 0.2226 0.898
Brugia malayi nuclear receptor NHR-88 0.01 0.0981 0.0981
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0306
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0577 0.0577
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0063 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0029 0.0195 0.0195
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0306
Mycobacterium leprae conserved hypothetical protein 0.0142 0.1443 0.4176
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.01 0.0981 0.1042
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0063 0.0563 0.0598
Echinococcus granulosus dnaJ subfamily B 0.0403 0.4332 0.4602
Brugia malayi hypothetical protein 0.0729 0.7946 0.7946
Loa Loa (eye worm) hypothetical protein 0.01 0.0981 0.0981
Loa Loa (eye worm) hypothetical protein 0.0213 0.2226 0.2226
Loa Loa (eye worm) hypothetical protein 0.0302 0.3212 0.3212
Schistosoma mansoni hypothetical protein 0.0095 0.0927 0.0985
Echinococcus multilocularis Nuclear hormone receptor HR96 0.01 0.0981 0.1042
Echinococcus multilocularis thioredoxin glutathione reductase 0.0129 0.1295 0.1376
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0195 0.0207
Loa Loa (eye worm) hypothetical protein 0.0083 0.0793 0.0793
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.3325 0.3325
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0044 0.036 0.1087
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0566 0.0601
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0577 0.0613
Mycobacterium tuberculosis Probable lipase LipD 0.0142 0.1443 0.1455
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0262 0.079
Brugia malayi hypothetical protein 0.0112 0.1114 0.1114
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0476 0.0743
Toxoplasma gondii protein kinase, putative 0.0589 0.6398 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.081 0.081
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0044 0.036 0.036
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Leishmania major myo-inositol-1 phosphatase, putative 0.0012 0.0004 0.0013
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0116 0.1152 1
Trypanosoma brucei glucose transporter, putative 0.0065 0.0587 0.177
Trypanosoma brucei glucose transporter, putative 0.0065 0.0587 0.177
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0116 0.1152 0.3476
Leishmania major glucose transporter, lmgt2 0.0065 0.0587 0.177
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0374 0.0374
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.0012 0.0004 0.0017
Giardia lamblia Hypothetical protein 0.0012 0.0004 0.0075
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0213 0.2226 0.2226
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0678 0.2046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0213 0.2226 0.2226
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0101 0.0306
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.036 0.1087
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0053 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0306
Trypanosoma brucei glucose transporter, putative 0.0065 0.0587 0.177
Schistosoma mansoni glucose transport protein 0.0209 0.2181 0.2316
Schistosoma mansoni hypothetical protein 0.0012 0.0004 0.0004
Echinococcus granulosus neuropeptide s receptor 0.046 0.4963 0.5272
Onchocerca volvulus Bile acid receptor homolog 0.0213 0.2226 0.898
Toxoplasma gondii thioredoxin reductase 0.0128 0.1284 0.2007
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0324 0.0979
Leishmania major glucose transporter, lmgt3 0.0065 0.0587 0.177
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.2137 0.8623
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0044 0.036 0.1087
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0205 0.0217
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0049 0.0052
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.01 0.0981 0.3959
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0186 0.0197
Brugia malayi nuclear receptor RXR 0.01 0.0981 0.0981
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0049 0.0052
Toxoplasma gondii NADPH-glutathione reductase 0.0044 0.036 0.0563
Echinococcus granulosus neuropeptide receptor A26 0.046 0.4963 0.5272
Loa Loa (eye worm) hypothetical protein 0.0213 0.2226 0.2226
Plasmodium falciparum pyruvate kinase 0.0033 0.0234 0.0242
Brugia malayi hypothetical protein 0.0112 0.1114 0.1114
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0282 0.0847
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.1905 0.2024
Mycobacterium tuberculosis Probable esterase LipL 0.0142 0.1443 0.1455
Mycobacterium ulcerans monophosphatase 0.0012 0.0004 0.0025
Loa Loa (eye worm) hypothetical protein 0.0085 0.081 0.081
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0234 0.0943
Brugia malayi beta-lactamase 0.0142 0.1443 0.1443
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0195 0.1157
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0324 0.2816
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0577 0.0577
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0101 0.0102
Loa Loa (eye worm) hypothetical protein 0.0064 0.0577 0.0577
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0577 0.0613
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0213 0.2226 0.2364
Echinococcus granulosus beta LACTamase domain containing family member 0.0142 0.1443 0.1533
Mycobacterium ulcerans monophosphatase CysQ 0.0012 0.0004 0.0025
Loa Loa (eye worm) hypothetical protein 0.0029 0.0195 0.0195
Onchocerca volvulus 0.0029 0.0195 0.0786
Mycobacterium ulcerans sugar transporter 0.0029 0.0195 0.1157
Loa Loa (eye worm) hypothetical protein 0.0033 0.0234 0.0234
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0195 0.1157
Brugia malayi nuclear hormone receptor 0.0213 0.2226 0.2226
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0324 0.0344
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Echinococcus multilocularis nuclear receptor nhr 48 0.01 0.0981 0.1042
Treponema pallidum NADH oxidase 0.0044 0.036 0.5048
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1499 0.4526
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0234 0.0943
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0213 0.2226 0.2226
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0324 0.0979
Brugia malayi MH1 domain containing protein 0.0016 0.0049 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0306
Mycobacterium ulcerans hypothetical protein 0.0164 0.1684 1
Leishmania major hypothetical protein, conserved 0.0142 0.1443 0.4356
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0063 0.0563 0.489
Leishmania major DNA polymerase kappa, putative 0.0021 0.0101 0.0306
Toxoplasma gondii hypothetical protein 0.0026 0.016 0.0251
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0053 0.0317
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0282 0.2446
Mycobacterium tuberculosis Probable dehydrogenase 0.0291 0.3096 0.312
Echinococcus granulosus General substrate transporter 0.0179 0.1856 0.1971
Trichomonas vaginalis D-aminoacylase, putative 0.0142 0.1443 0.434
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2163 0.2163
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0142 0.1443 0.1455
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0306
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0713 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0308 0.0891
Onchocerca volvulus 0.0029 0.0195 0.0786
Plasmodium vivax glutathione reductase, putative 0.0128 0.1284 0.1327
Brugia malayi conserved hypotetical protein 0.01 0.0981 0.0981
Echinococcus multilocularis pyruvate kinase 0.0017 0.0057 0.006
Onchocerca volvulus 0.0029 0.0195 0.0786
Schistosoma mansoni hypothetical protein 0.0209 0.2181 0.2316
Schistosoma mansoni protein kinase 0.0064 0.0577 0.0613
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0587 0.1764
Schistosoma mansoni sugar transporter 0.0029 0.0195 0.0207
Brugia malayi Inositol monophosphatase family protein 0.0012 0.0004 0.0004
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.0927 0.0927
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0116 0.1152 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0112 0.1114 0.1114
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0116 0.1152 0.3476
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0282 0.085
Onchocerca volvulus 0.0085 0.081 0.327
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0324 0.0344
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0137 0.0146
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0053 0.0317
Schistosoma mansoni ferritin light chain 0.0017 0.0053 0.0057
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0213 0.2226 0.2364
Loa Loa (eye worm) hypothetical protein 0.0029 0.0195 0.0195
Trichomonas vaginalis ferritin, putative 0.0017 0.0053 0.0161
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0566 0.0566
Plasmodium falciparum protein kinase 7 0.0589 0.6398 0.6612
Leishmania major trypanothione reductase 0.0128 0.1284 0.3876
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0587 0.1764
Onchocerca volvulus 0.01 0.0981 0.3959
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0907 0.9922 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0525 0.0557
Onchocerca volvulus 0.0149 0.1517 0.6122
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Trypanosoma brucei glucose transporter, putative 0.0065 0.0587 0.177
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0324 0.0344
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0324 0.3456 1
Mycobacterium leprae Probable lipase LipE 0.0142 0.1443 0.4176
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0213 0.2226 0.2364
Schistosoma mansoni smad1 5 8 and 0.0016 0.0049 0.0052
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0012 0.0004 0.0013
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0195 0.0588
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0234 0.0943
Echinococcus multilocularis solute carrier family 22 0.0029 0.0195 0.0207
Echinococcus granulosus lamin 0.0085 0.081 0.0861
Schistosoma mansoni nuclear receptor nhr-48 0.01 0.0981 0.1042
Loa Loa (eye worm) nuclear receptor nhr-7B 0.01 0.0981 0.0981
Echinococcus multilocularis neuropeptide receptor A26 0.046 0.4963 0.5272
Brugia malayi hypothetical protein 0.0039 0.0301 0.0301
Onchocerca volvulus 0.0142 0.1443 0.5824
Brugia malayi glutathione reductase 0.0128 0.1284 0.1284
Toxoplasma gondii hypothetical protein 0.005 0.0425 0.0665
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0386 0.2291
Onchocerca volvulus 0.0029 0.0195 0.0786
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0101 0.0306
Echinococcus multilocularis lamin 0.0085 0.081 0.0861
Trichomonas vaginalis D-aminoacylase, putative 0.0142 0.1443 0.434
Plasmodium vivax thioredoxin reductase, putative 0.0128 0.1284 0.1327
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0577 0.0613
Schistosoma mansoni DNA polymerase eta 0.0021 0.0101 0.0108
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0184 0.1905 0.1905
Loa Loa (eye worm) hypothetical protein 0.01 0.0981 0.0981
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0195 0.0586
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.0012 0.0004 0.0013
Loa Loa (eye worm) Smad1 0.0016 0.0049 0.0049
Schistosoma mansoni sugar transporter 0.0029 0.0195 0.0207
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0234 0.0677
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2181 0.2316
Schistosoma mansoni protein kinase 0.0064 0.0577 0.0613
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0563 0.0598
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.0927 0.0985
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0234 0.0703
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0301 0.032
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0234 0.0234
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0195 0.0195
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0044 0.036 0.1087
Echinococcus multilocularis lamin dm0 0.0085 0.081 0.0861
Loa Loa (eye worm) hypothetical protein 0.0213 0.2226 0.2226
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0205 0.0217
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0104 0.1017 0.2944
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.0578 0.0597
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0534 0.0567
Echinococcus multilocularis Nuclear hormone receptor HR96 0.01 0.0981 0.1042
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.1684 0.1697
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0466 0.0482
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0213 0.2226 0.2226
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0713 0.1115
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0195 0.0195
Echinococcus multilocularis inositol monophosphatase 1 0.0116 0.1152 0.1223
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0354 0.1069
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0124 0.0124
Schistosoma mansoni glucose transport protein 0.0209 0.2181 0.2316
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0301 0.032
Loa Loa (eye worm) hypothetical protein 0.0142 0.1443 0.1443
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.036 0.1087
Schistosoma mansoni hypothetical protein 0.0024 0.0137 0.0146
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0101 0.0305
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0291 0.3096 0.312
Echinococcus granulosus geminin 0.0861 0.9415 1
Brugia malayi Sugar transporter family protein 0.0029 0.0195 0.0195
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.1905 0.2024
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0195 0.0207
Giardia lamblia Pyruvate kinase 0.0017 0.0057 0.1007
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0577 0.0613
Brugia malayi Probable ClpP-like protease 0.0076 0.0713 0.0713
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.1905 0.2024
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0101 0.0108
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3325 1
Brugia malayi nuclear receptor RXR 0.0112 0.1114 0.1114
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0044 0.036 0.5048
Brugia malayi intermediate filament protein 0.0085 0.081 0.081
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0282 0.5001
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0049 0.0052
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0466 0.0482
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0101 0.0306
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0213 0.2226 0.2226
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.0578 0.0903
Echinococcus granulosus inositol monophosphatase 0.0012 0.0004 0.0004
Leishmania major mitochondrial DNA polymerase beta 0.0311 0.3313 1
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0012 0.0004 0.0004
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0324 0.0324
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0205 0.032
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0213 0.2226 0.2364
Loa Loa (eye worm) hypothetical protein 0.0029 0.0195 0.0195
Mycobacterium tuberculosis Conserved protein 0.0142 0.1443 0.1455
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0213 0.2226 0.2226
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Schistosoma mansoni hypothetical protein 0.0861 0.9415 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.01 0.0981 0.0981
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0101 0.0602
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0306
Echinococcus granulosus survival motor neuron protein 1 0.0729 0.7946 0.8441
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.1905 0.2024
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0324 0.0979
Echinococcus granulosus solute carrier family 22 0.0029 0.0195 0.0207
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0587 0.177
Trichomonas vaginalis D-aminoacylase, putative 0.0142 0.1443 0.434
Loa Loa (eye worm) hypothetical protein 0.01 0.0981 0.0981
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.016 0.225
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.2181 0.2316
Trypanosoma brucei glucose transporter, putative 0.0065 0.0587 0.177
Giardia lamblia NADH oxidase lateral transfer candidate 0.0044 0.036 0.6393
Loa Loa (eye worm) hypothetical protein 0.01 0.0981 0.0981
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0142 0.1443 0.1533
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0713 0.0758
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0044 0.036 0.0382
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0386 0.041
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0713 0.0758
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0713 0.0737
Loa Loa (eye worm) hypothetical protein 0.0047 0.0386 0.0386
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.0012 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0029 0.0195 0.0195
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0324 0.0344
Plasmodium vivax SET domain protein, putative 0.003 0.0205 0.0211
Echinococcus granulosus GPCR family 2 0.0095 0.0927 0.0985
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0213 0.2226 0.2364
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0063 0.0563 0.1629
Onchocerca volvulus 0.0029 0.0195 0.0786
Chlamydia trachomatis 3'(2'),5'-bisphosphate nucleotidase CysQ 0.0012 0.0004 0.0059
Plasmodium falciparum proline--tRNA ligase 0.0073 0.0678 0.0701
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0205 0.0217
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0324 0.0979
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0195 0.0201
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0205 0.0217
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0386 0.1164
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0044 0.036 0.2138
Plasmodium falciparum hexose transporter 0.0209 0.2181 0.2253
Mycobacterium ulcerans inositol-monophosphatase ImpA 0.0012 0.0004 0.0025
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0063 0.0563 0.0563
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0012 0.0004 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.003 0.0089
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.0578 0.0597
Onchocerca volvulus 0.003 0.0205 0.0826
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0282 0.0299
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0566 0.0566
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.0927 0.0985
Echinococcus granulosus ecdysone induced protein 78C 0.0213 0.2226 0.2364
Echinococcus multilocularis solute carrier family 22 0.0029 0.0195 0.0207
Brugia malayi hypothetical protein 0.0029 0.0195 0.0195
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.0927 0.0985
Trichomonas vaginalis esterase, putative 0.0142 0.1443 0.434
Trichomonas vaginalis inositol monophosphatase, putative 0.0012 0.0004 0.0013
Loa Loa (eye worm) sugar transporter 0.0029 0.0195 0.0195
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0116 0.1152 0.18
Echinococcus multilocularis solute carrier family 22 0.0029 0.0195 0.0207
Loa Loa (eye worm) hypothetical protein 0.01 0.0981 0.0981
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.0578 0.0597
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0282 0.2446
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0195 0.0195
Schistosoma mansoni nuclear hormone receptor 0.01 0.0981 0.1042
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0195 0.0586
Entamoeba histolytica hypothetical protein 0.0039 0.0301 0.2617
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0354 0.1069
Loa Loa (eye worm) hypothetical protein 0.0041 0.0324 0.0324
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0713 1
Brugia malayi MH1 domain containing protein 0.0016 0.0049 0.0049
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0234 0.0703
Echinococcus multilocularis Smad4 0.0016 0.0049 0.0052
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0101 0.0306
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Echinococcus granulosus dna polymerase kappa 0.0021 0.0101 0.0108
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.0578 0.0903
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0213 0.2226 0.2364
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.01 0.0981 0.3959
Onchocerca volvulus Putative transporter 0.0029 0.0195 0.0786
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0386 0.1116
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1499 0.4526
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0466 0.0482
Trypanosoma brucei glucose transporter, putative 0.0065 0.0587 0.177
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Schistosoma mansoni ap endonuclease 0.0037 0.0282 0.0299
Leishmania major glucose transporter, lmgt1 0.0065 0.0587 0.177
Loa Loa (eye worm) hypothetical protein 0.01 0.0981 0.0981
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0101 0.0108
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0213 0.2226 0.2364
Loa Loa (eye worm) hypothetical protein 0.0063 0.0563 0.0563
Echinococcus multilocularis neuropeptide s receptor 0.046 0.4963 0.5272
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Brugia malayi CXXC zinc finger family protein 0.0028 0.0183 0.0183
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.1905 0.2024
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0195 0.0588
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0322 0.0969
Mycobacterium ulcerans lipase LipD 0.0142 0.1443 0.8573
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0525 0.0557
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0195 0.0586
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0466 0.0728
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0112 0.1114 0.1184
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0213 0.2226 0.2226
Mycobacterium ulcerans beta-lactamase 0.0142 0.1443 0.8573
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0386 0.1164
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0142 0.1443 0.1533
Loa Loa (eye worm) hypothetical protein 0.0041 0.0324 0.0324
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0423 0.0426
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0306
Echinococcus multilocularis General substrate transporter 0.0179 0.1856 0.1971
Loa Loa (eye worm) inositol-1 0.0116 0.1152 0.1152
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2137 0.6427
Brugia malayi nuclear hormone receptor 0.01 0.0981 0.0981
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0213 0.2226 0.2364
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0116 0.1152 0.3463
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3325 1
Mycobacterium tuberculosis Monophosphatase CysQ 0.0012 0.0004 0.0004
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0324 0.0344
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0183 0.0183
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0213 0.2226 0.2364
Brugia malayi orphan nuclear receptor NR2E1 0.01 0.0981 0.0981
Onchocerca volvulus 0.0029 0.0195 0.0786
Giardia lamblia Hexose transporter 0.0029 0.0195 0.3459
Echinococcus granulosus dna polymerase eta 0.0021 0.0101 0.0108
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0423 0.0449
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0213 0.2226 0.2364
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0057 0.0089
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0566 0.0601
Loa Loa (eye worm) DR-78 0.01 0.0981 0.0981
Brugia malayi steroid hormone receptor 0.0213 0.2226 0.2226
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0213 0.2226 0.2364
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0195 0.0586
Plasmodium falciparum thioredoxin reductase 0.0128 0.1284 0.1327
Onchocerca volvulus 0.0142 0.1443 0.5824
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0302 0.3212 0.3212
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0116 0.1152 0.3476
Brugia malayi ecdysone receptor 0.01 0.0981 0.0981
Onchocerca volvulus 0.0029 0.0195 0.0786
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.2492 0.2492
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0324 0.3456 0.3483
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0234 0.0365
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0049 0.0052
Schistosoma mansoni lamin 0.0085 0.081 0.0861
Echinococcus multilocularis expressed protein 0.0017 0.0053 0.0057
Echinococcus granulosus thioredoxin glutathione reductase 0.0129 0.1295 0.1376
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0213 0.2226 0.2226
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0112 0.1114 0.1184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.1905 0.2024
Brugia malayi Latrophilin receptor protein 2 0.0095 0.0927 0.0927
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0184 0.1905 0.1905
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0195 0.0588
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0063 0.0563 0.0598
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0124 0.1074
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0101 0.0306
Schistosoma mansoni inositol monophosphatase 0.0116 0.1152 0.1223
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.2492 0.2492
Schistosoma mansoni pyruvate kinase 0.0033 0.0234 0.0248
Brugia malayi TAR-binding protein 0.0063 0.0566 0.0566
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.1499 0.4526
Loa Loa (eye worm) hypothetical protein 0.0112 0.1114 0.1114
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0386 0.041
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0044 0.036 0.2138
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Brugia malayi hypothetical protein 0.0054 0.0466 0.0466
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0104 0.1017 0.1025
Schistosoma mansoni pyruvate kinase 0.0033 0.0234 0.0248
Echinococcus granulosus Smad4 0.0016 0.0049 0.0052
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0137 0.0146
Schistosoma mansoni smad1 5 8 and 0.0016 0.0049 0.0052
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0205 0.0217
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2259 0.6794
Entamoeba histolytica protein kinase, putative 0.0064 0.0577 0.5014
Loa Loa (eye worm) thioredoxin reductase 0.0128 0.1284 0.1284
Schistosoma mansoni hypothetical protein 0.0149 0.1517 0.1612
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0423 0.1223
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0195 0.0207
Toxoplasma gondii hypothetical protein 0.0012 0.0004 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0101 0.0306
Echinococcus multilocularis pyruvate kinase 0.0033 0.0234 0.0248
Echinococcus granulosus intermediate filament protein 0.0085 0.081 0.0861
Schistosoma mansoni intermediate filament proteins 0.0085 0.081 0.0861
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0466 0.1406
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0291 0.3096 0.8958
Leishmania major pyruvate kinase 0.0033 0.0234 0.0706
Echinococcus multilocularis geminin 0.0861 0.9415 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0234 0.0706
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0053 0.0054
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0116 0.1152 0.3476
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0282 0.0299
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0205 0.0217
Plasmodium falciparum glutathione reductase 0.0128 0.1284 0.1327
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0577 0.0577
Schistosoma mansoni hypothetical protein 0.0012 0.0004 0.0004
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0032 0.023 0.023
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0142 0.1443 0.1455
Brugia malayi Nuclear hormone receptor-like 1 0.0112 0.1114 0.1114
Onchocerca volvulus 0.0029 0.0195 0.0786
Loa Loa (eye worm) hypothetical protein 0.0213 0.2226 0.2226
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2137 0.6427
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0291 0.3096 0.312
Loa Loa (eye worm) nuclear hormone receptor 0.01 0.0981 0.0981
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0101 0.0102
Schistosoma mansoni hypothetical protein 0.0039 0.0301 0.032
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0044 0.036 0.0563
Loa Loa (eye worm) hypothetical protein 0.01 0.0981 0.0981
Schistosoma mansoni nuclear receptor 0.01 0.0981 0.1042
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Brugia malayi hypothetical protein 0.01 0.0981 0.0981
Loa Loa (eye worm) hypothetical protein 0.0095 0.0927 0.0927
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0213 0.2226 0.2226
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0324 0.0975
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0012 0.0004 0.0013
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0337 0.3604 0.5632
Brugia malayi nuclear hormone receptor family member odr-7 0.01 0.0981 0.0981
Schistosoma mansoni retinoic acid receptor RXR 0.0213 0.2226 0.2364
Trypanosoma cruzi trypanothione reductase, putative 0.0128 0.1284 0.3876
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0577 0.1737
Toxoplasma gondii facilitative glucose transporter GT1 0.0209 0.2181 0.3408
Onchocerca volvulus 0.0085 0.081 0.327
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3325 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.003 0.0089
Schistosoma mansoni apoferritin-2 0.0017 0.0053 0.0057
Brugia malayi Inositol monophosphatase family protein 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.01 0.0981 0.0981
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.0578 0.0903
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3325 1
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0115 0.1609
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0213 0.2226 0.2364
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0324 0.0344
Schistosoma mansoni thyroid hormone receptor 0.0213 0.2226 0.2364
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.0578 0.0597
Echinococcus granulosus cpg binding protein 0.003 0.0201 0.0214
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Chlamydia trachomatis pyruvate kinase 0.0033 0.0234 0.3279
Onchocerca volvulus 0.0029 0.0195 0.0786
Brugia malayi ecdysteroid receptor 0.0213 0.2226 0.2226
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0044 0.036 0.3126
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0713 0.0758
Loa Loa (eye worm) hypothetical protein 0.0213 0.2226 0.2226
Leishmania major hypothetical protein, conserved 0.0029 0.0195 0.0588
Brugia malayi hypothetical protein 0.0035 0.0255 0.0255
Mycobacterium tuberculosis Probable reductase 0.0291 0.3096 0.312
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0063 0.0563 0.1694
Onchocerca volvulus 0.0235 0.2478 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0291 0.3096 0.312
Plasmodium falciparum protein kinase 6 0.0885 0.9677 1
Loa Loa (eye worm) hypothetical protein 0.0729 0.7946 0.7946
Echinococcus granulosus solute carrier family 22 0.0029 0.0195 0.0207
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0154 0.0154
Trypanosoma cruzi hypothetical protein, conserved 0.0142 0.1443 0.4356
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.01 0.0981 0.0981
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0057 0.0059
Mycobacterium tuberculosis Probable monophosphatase 0.0012 0.0004 0.0004
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0195 0.0195
Trypanosoma brucei sugar transporter, putative 0.0029 0.0195 0.0588
Mycobacterium tuberculosis Conserved protein 0.0142 0.1443 0.1455
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0311 0.3313 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0112 0.1114 0.1184
Mycobacterium ulcerans monophosphatase CysQ 0.0012 0.0004 0.0025
Loa Loa (eye worm) intermediate filament protein 0.0085 0.081 0.081
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0195 0.0196
Loa Loa (eye worm) hypothetical protein 0.0112 0.1114 0.1114
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0101 0.0108
Echinococcus granulosus pyruvate kinase 0.0033 0.0234 0.0248
Loa Loa (eye worm) hypothetical protein 0.0029 0.0195 0.0195
Plasmodium vivax hexose transporter 0.0209 0.2181 0.2253
Brugia malayi tailless protein 0.01 0.0981 0.0981
Schistosoma mansoni ferritin 0.0017 0.0053 0.0057
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.036 0.1087
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0525 0.0557
Trichomonas vaginalis inositol monophosphatase, putative 0.0012 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0213 0.2226 0.2226
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0566 0.0566
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0195 0.0588
Loa Loa (eye worm) steroid hormone receptor 0.0213 0.2226 0.2226
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0234 0.0706
Loa Loa (eye worm) hypothetical protein 0.0039 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.003 0.0205 0.0205
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2137 0.6427
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0577 0.1743
Plasmodium vivax hypothetical protein, conserved 0.0142 0.1443 0.1491
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0213 0.2226 0.2364
Brugia malayi Thioredoxin reductase 0.0128 0.1284 0.1284
Loa Loa (eye worm) hypothetical protein 0.0029 0.0195 0.0195
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0466 0.1406
Schistosoma mansoni glucose transport protein 0.0209 0.2181 0.2316
Giardia lamblia Prolyl-tRNA synthetase 0.0063 0.0563 1
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0386 0.041
Brugia malayi Cam kinase protein 1 0.0064 0.0577 0.0577
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0044 0.036 0.1087
Brugia malayi hypothetical protein 0.0029 0.0195 0.0195
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0195 0.0195
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0101 0.0108
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0101 0.0101
Trypanosoma brucei trypanothione reductase 0.0128 0.1284 0.3876
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2137 0.6427
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0386 0.0603
Brugia malayi beta-lactamase family protein 0.0142 0.1443 0.1443
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0101
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0423 0.0449
Schistosoma mansoni coup transcription factor 0.0213 0.2226 0.2364
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0587 0.1764
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0044 0.036 0.1087
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0577 0.0613
Schistosoma mansoni thyroid hormone receptor 0.0213 0.2226 0.2364
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0116 0.1152 0.3463
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0213 0.2226 0.2226
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.0578 0.0597
Trypanosoma brucei hypothetical protein, conserved 0.0142 0.1443 0.4356
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0213 0.2226 0.2226
Onchocerca volvulus 0.0029 0.0195 0.0786
Schistosoma mansoni ferritin 0.0017 0.0053 0.0057
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.01 0.0981 0.1042
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0324 0.5759
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0101 0.0306
Mycobacterium tuberculosis Probable oxidoreductase 0.0324 0.3456 0.3483
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.016 0.0166
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.2181 0.6558
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0012 0.0004 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3325 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0234 0.0706
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0282 0.085
Loa Loa (eye worm) hypothetical protein 0.0054 0.0466 0.0466
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0324 0.0344
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0213 0.2226 0.2226
Onchocerca volvulus 0.0213 0.2226 0.898
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0587 0.1764
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0234 0.0234
Schistosoma mansoni apoferritin-2 0.0017 0.0053 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0324 0.0975
Schistosoma mansoni nuclear receptor 0.01 0.0981 0.1042
Trypanosoma brucei glucose transporter 2A 0.0065 0.0587 0.177
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0213 0.2226 0.898
Brugia malayi nuclear receptor NHR-88 0.0213 0.2226 0.2226
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0032 0.023 0.023
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0386 0.0399
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.0578 0.0597
Schistosoma mansoni RAR-like nuclear receptor 0.0213 0.2226 0.2364
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.0578 0.0597
Mycobacterium ulcerans hypothetical protein 0.0142 0.1443 0.8573
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0044 0.036 0.1087
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0587 0.1764
Brugia malayi MH2 domain containing protein 0.0237 0.2492 0.2492
Brugia malayi Sugar transporter family protein 0.0029 0.0195 0.0195
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0234 0.0234
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.01 0.0981 0.1042
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0044 0.036 0.1087
Schistosoma mansoni nuclear hormone receptor 0.01 0.0981 0.1042
Schistosoma mansoni glucose transporter 0.0029 0.0195 0.0207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0213 0.2226 0.2226
Schistosoma mansoni smad 0.0016 0.0049 0.0052
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.0927 0.0927
Schistosoma mansoni nuclear hormone receptor 0.0213 0.2226 0.2364
Loa Loa (eye worm) hypothetical protein 0.0142 0.1443 0.1443
Giardia lamblia Pyruvate kinase 0.0033 0.0234 0.4152
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0713 0.2064
Echinococcus multilocularis musashi 0.0085 0.081 0.0861
Echinococcus granulosus tar DNA binding protein 0.0063 0.0566 0.0601
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0115 0.0682
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0049 0.0049
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0012 0.0004 0.0013
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0282 0.0282
Echinococcus multilocularis survival motor neuron protein 1 0.0729 0.7946 0.8441
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0713 0.0737
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.0012 0.0004 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0205 0.0217
Loa Loa (eye worm) hypothetical protein 0.0142 0.1443 0.1443
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0112 0.1114 0.1184
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0234 0.0236
Loa Loa (eye worm) hypothetical protein 0.0029 0.0195 0.0195
Leishmania major pyruvate kinase 0.0033 0.0234 0.0706
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0073 0.0678 0.106
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0566 0.0601
Schistosoma mansoni smad1 5 8 and 0.0016 0.0049 0.0052
Echinococcus granulosus ferritin 0.0017 0.0053 0.0057
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0044 0.036 0.3126
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0044 0.036 0.0382
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0534 0.0567
Echinococcus multilocularis pyruvate kinase 0.0026 0.0157 0.0167
Echinococcus multilocularis inositol monophosphatase 0.0012 0.0004 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0213 0.2226 0.2364
Echinococcus granulosus pyruvate kinase 0.0033 0.0234 0.0248
Loa Loa (eye worm) glutathione reductase 0.0128 0.1284 0.1284
Echinococcus multilocularis pyruvate kinase 0.0017 0.0057 0.006
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0525 0.3117
Toxoplasma gondii ABC1 family protein 0.0142 0.1443 0.2256
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3325 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0142 0.1443 0.1443
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0049 0.0049
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0566 0.0601
Echinococcus multilocularis pyruvate kinase 0.0033 0.0234 0.0248
Echinococcus granulosus expressed protein 0.0017 0.0053 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2259 0.6794
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0587 0.1764
Loa Loa (eye worm) hypothetical protein 0.0029 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.01 0.0981 0.0981
Schistosoma mansoni zinc finger protein 0.01 0.0981 0.1042
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0195 0.1692
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.1905 0.2024
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0101 0.0101
Brugia malayi Steroid receptor seven-up type 2 0.0213 0.2226 0.2226
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0116 0.1152 0.684
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0354 0.1069
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0713 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0587 0.177
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0213 0.2226 0.2226
Onchocerca volvulus 0.0029 0.0195 0.0786
Entamoeba histolytica hypothetical protein 0.0039 0.0301 0.2617
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Loa Loa (eye worm) hypothetical protein 0.0213 0.2226 0.2226
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0195 0.0196
Brugia malayi nuclear hormone receptor family member nhr-6 0.01 0.0981 0.0981
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0053 0.0054
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0374 0.0374
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.0927 0.0985
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Echinococcus granulosus lamin dm0 0.0085 0.081 0.0861
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0306
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0587 0.177
Schistosoma mansoni ferritin 0.0017 0.0053 0.0057
Schistosoma mansoni sugar transporter 0.0029 0.0195 0.0207
Mycobacterium ulcerans esterase/lipase LipP 0.0142 0.1443 0.8573
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2137 0.6427
Entamoeba histolytica hypothetical protein 0.0039 0.0301 0.2617
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0195 0.0207
Schistosoma mansoni hypothetical protein 0.0861 0.9415 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0142 0.1443 0.1443
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0386 0.1164
Schistosoma mansoni Smad4 0.0016 0.0049 0.0052
Schistosoma mansoni lamin 0.0085 0.081 0.0861
Brugia malayi RNA binding protein 0.0063 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0206 0.2154 0.2154
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0101 0.0306
Schistosoma mansoni hypothetical protein 0.0403 0.4332 0.4602
Echinococcus multilocularis smad 0.0016 0.0049 0.0052
Echinococcus granulosus Nuclear hormone receptor HR96 0.01 0.0981 0.1042
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0547 0.0581
Schistosoma mansoni ap endonuclease 0.0037 0.0282 0.0299
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0563 0.0598
Brugia malayi MH2 domain containing protein 0.0016 0.0049 0.0049
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0142 0.1443 0.8573
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0282 0.0282
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0282 0.085
Schistosoma mansoni hypothetical protein 0.0095 0.0927 0.0985
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0044 0.036 0.0372
Loa Loa (eye worm) hypothetical protein 0.0039 0.0307 0.0307
Echinococcus granulosus FTZ F1 alpha 0.0213 0.2226 0.2364
Brugia malayi Calcitonin receptor-like protein seb-1 0.0302 0.3212 0.3212
Echinococcus multilocularis GPCR, family 2 0.0095 0.0927 0.0985
Onchocerca volvulus 0.0029 0.0195 0.0786
Onchocerca volvulus 0.0029 0.0195 0.0786
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0386 0.116
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Echinococcus multilocularis beta LACTamase domain containing family member 0.0142 0.1443 0.1533
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.01 0.0981 0.1042
Trichomonas vaginalis glutathione reductase, putative 0.0044 0.036 0.1083
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0195 0.0586
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0678 0.2046
Onchocerca volvulus 0.0029 0.0195 0.0786
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0308 0.031
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0213 0.2226 0.2364
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0012 0.0004 0.0013
Brugia malayi Nuclear hormone receptor E75 0.01 0.0981 0.0981
Schistosoma mansoni ferritin 0.0017 0.0053 0.0057
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.2181 0.2316
Loa Loa (eye worm) hypothetical protein 0.0029 0.0195 0.0195
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0713 0.1115
Schistosoma mansoni sugar transporter 0.0029 0.0195 0.0207
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0053 0.0464
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0209 0.2181 0.2316
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0386 0.5408
Echinococcus granulosus Nuclear hormone receptor HR96 0.01 0.0981 0.1042
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.3313 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0525 0.0529
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0112 0.1114 0.1114
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0101 0.0108
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0195 0.0586
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0234 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0213 0.2226 0.2226
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.3325 0.3325
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.036 0.1087
Mycobacterium tuberculosis Probable lipase LipE 0.0142 0.1443 0.1455
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0324 0.3456 0.3483
Onchocerca volvulus 0.0028 0.0183 0.0739
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0101 0.0305
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0044 0.036 0.0372
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0423 0.0426
Brugia malayi hypothetical protein 0.01 0.0981 0.0981
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2137 0.6427
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0577 0.0613
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.016 0.0464
Echinococcus multilocularis ecdysone induced protein 78C 0.0213 0.2226 0.2364
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0195 0.0304
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0354 0.1069
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0282 0.0847
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2137 0.6427
Toxoplasma gondii exonuclease III APE 0.0037 0.0282 0.044
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0566 0.0601
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0049 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0195 0.0586
Mycobacterium tuberculosis Conserved protein 0.0142 0.1443 0.1455
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0713 0.6193
Schistosoma mansoni pap-inositol-14-phosphatase 0.0012 0.0004 0.0004
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0337 0.3604 0.3724
Onchocerca volvulus 0.0029 0.0195 0.0786
Brugia malayi MH2 domain containing protein 0.0016 0.0049 0.0049
Loa Loa (eye worm) sugar transporter 0.0209 0.2181 0.2181
Brugia malayi major facilitator superfamily protein 0.0029 0.0195 0.0195
Echinococcus multilocularis cpg binding protein 0.003 0.0201 0.0214
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.081 0.081
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0234 0.0706
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0282 0.0291
Giardia lamblia Sugar-proton symporter 0.0029 0.0195 0.3459
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0466 0.1406
Trypanosoma brucei unspecified product 0.0021 0.0101 0.0306
Plasmodium falciparum thioredoxin reductase 0.0044 0.036 0.0372
Loa Loa (eye worm) hypothetical protein 0.01 0.0981 0.0981
Loa Loa (eye worm) hypothetical protein 0.0029 0.0195 0.0195
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0101 0.0101
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0234 0.0242
Loa Loa (eye worm) hypothetical protein 0.0023 0.0124 0.0124
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0525 0.082
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0282 0.0284
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0044 0.036 0.1087
Schistosoma mansoni survival motor neuron protein 0.0149 0.1517 0.1612
Brugia malayi Nuclear hormone receptor-like 1 0.0112 0.1114 0.1114
Toxoplasma gondii sugar transporter ST1 0.0029 0.0195 0.0304
Trichomonas vaginalis penicillin-binding protein, putative 0.0142 0.1443 0.434
Schistosoma mansoni ferritin light chain 0.0017 0.0053 0.0057
Schistosoma mansoni inositol monophosphatase 0.0116 0.1152 0.1223
Brugia malayi Pre-SET motif family protein 0.003 0.0205 0.0205
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.0578 0.0597
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0044 0.036 0.1087
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.3313 1
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0386 0.041
Leishmania major protein kinase, putative 0.0064 0.0577 0.1743
Echinococcus multilocularis solute carrier family 22 0.0029 0.0195 0.0207
Schistosoma mansoni cpg binding protein 0.003 0.0201 0.0214
Echinococcus granulosus pyruvate kinase 0.0017 0.0057 0.006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0195 0.0195
Plasmodium vivax CDK-related protein kinase 6, putative 0.0885 0.9677 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 9.4662 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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