TDR Targets

Basic information

Technical information

TDR Targets ID: 1295226
Name: 2-[methyl-[2-(2-naphthalen-1-yloxyethoxy)ethy l]amino]ethanol
MW: 289.369 | Formula: C17H23NO3
H donors: 1 H acceptors: 1 LogP: 2.35 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: OCCN(CCOCCOc1cccc2c1cccc2)C
InChi: 1S/C17H23NO3/c1-18(9-11-19)10-12-20-13-14-21-17-8-4-6-15-5-2-3-7-16(15)17/h2-8,19H,9-14H2,1H3
InChiKey: RTKIKFKAHJNQDP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[methyl-[2-[2-(1-naphthyloxy)ethoxy]ethyl]amino]ethanol
MLS000760300
SMR000373017

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lysine (K)-specific demethylase 4A	Starlite/ChEMBL	No references
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references
Giardia intestinalis	Putative fructose-1,6-bisphosphate aldolase	Starlite/ChEMBL	No references
Bacillus subtilis	4'-phosphopantetheinyl transferase ffp	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Echinococcus granulosus	L aminoadipate semialdehyde	Get druggable targets OG5_129301	All targets in OG5_129301
Echinococcus granulosus	Transcription factor JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Probable JmjC domain-containing histone demethylation protein 3B, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Onchocerca volvulus		Get druggable targets OG5_129301	All targets in OG5_129301
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Brugia malayi	jmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Giardia lamblia	Fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Cryptosporidium parvum	phosphopantetheinyl transferase	Get druggable targets OG5_129301	All targets in OG5_129301
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	JmjC domain-containing histone demethylation protein 3C, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	jmjC domain-containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Get druggable targets OG5_129301	All targets in OG5_129301
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Echinococcus multilocularis	L aminoadipate semialdehyde	Get druggable targets OG5_129301	All targets in OG5_129301
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	expressed protein	Get druggable targets OG5_129301	All targets in OG5_129301
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative	Get druggable targets OG5_129301	All targets in OG5_129301
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Cryptosporidium hominis	proteinx0005	Get druggable targets OG5_129301	All targets in OG5_129301
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	Get druggable targets OG5_129301	All targets in OG5_129301
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Treponema pallidum	fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129301	All targets in OG5_129301
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trichomonas vaginalis	conserved hypothetical protein	4'-phosphopantetheinyl transferase ffp	224 aa	197 aa	22.3 %
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %
Mycobacterium ulcerans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	26.9 %
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.8 %
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.5 %
Candida albicans	aminoadipate-semialdehyde dehydrogenase small subunit	4'-phosphopantetheinyl transferase ffp	224 aa	183 aa	27.3 %
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %
Onchocerca volvulus		4'-phosphopantetheinyl transferase ffp	224 aa	186 aa	26.3 %
Entamoeba histolytica	hypothetical protein	4'-phosphopantetheinyl transferase ffp	224 aa	198 aa	28.3 %
Candida albicans	aminoadipate-semialdehyde dehydrogenase small subunit	4'-phosphopantetheinyl transferase ffp	224 aa	183 aa	27.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	PH domain containing protein	0.0112	0.0098	0.0098
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0112	0.0098	0.0061
Schistosoma mansoni	sortingnexin-related	0.0279	0.0359	0.0324
Echinococcus granulosus	pleckstrin y domain containing family A	0.0112	0.0098	0.0061
Loa Loa (eye worm)	Plekhf2 protein	0.0112	0.0098	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Echinococcus granulosus	sorting nexin 4	0.0279	0.0359	0.0324
Echinococcus granulosus	phospholipase D	0.5673	0.8824	0.882
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.0475	1
Loa Loa (eye worm)	hypothetical protein	0.4182	0.6485	0.7733
Loa Loa (eye worm)	hypothetical protein	0.0279	0.0359	0.0428
Schistosoma mansoni	hypothetical protein	0.0112	0.0098	0.0061
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0112	0.0098	0.0061
Onchocerca volvulus	Putative phospholipase D	0.1211	0.1823	1
Schistosoma mansoni	dynamin	0.0112	0.0098	0.0061
Echinococcus granulosus	oxysterol binding protein 9	0.0112	0.0098	0.0061
Echinococcus multilocularis	Oxysterol binding protein 11	0.0112	0.0098	0.0061
Brugia malayi	PH domain containing protein	0.0112	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Leishmania major	hypothetical protein, conserved	0.0279	0.0359	0.1806
Brugia malayi	Phospholipase D. Active site motif family protein	0.1211	0.1823	0.1823
Brugia malayi	PX domain containing protein	0.0279	0.0359	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Schistosoma mansoni	sorting nexin	0.0279	0.0359	0.0324
Loa Loa (eye worm)	phosphatidylinositol 3-kinase catalytic subunit gamma	0.0279	0.0359	0.0428
Brugia malayi	PH domain containing protein	0.0112	0.0098	0.0098
Plasmodium vivax	WD domain, G-beta repeat domain containing protein	0.0279	0.0359	0.1819
Leishmania major	phosphatidylglycerophosphate synthase, putative	0.1211	0.1823	1
Echinococcus granulosus	cytohesin 1	0.0112	0.0098	0.0061
Trypanosoma cruzi	zinc finger protein kinase, putative	0.0279	0.0359	0.0783
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.0475	0.0382
Brugia malayi	PH domain containing protein	0.0112	0.0098	0.0098
Brugia malayi	PX domain containing protein	0.0279	0.0359	0.0359
Trypanosoma brucei	PX domain containing protein, putative	0.0279	0.0359	0.0783
Trypanosoma cruzi	PX domain containing protein, putative	0.0279	0.0359	0.0783
Schistosoma mansoni	sorting nexin	0.0279	0.0359	0.0324
Loa Loa (eye worm)	hypothetical protein	0.006	0.0016	0.0019
Onchocerca volvulus		0.0112	0.0098	0.0106
Echinococcus granulosus	GRB2 associated binding protein 3	0.0112	0.0098	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0279	0.0359	0.6922
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Echinococcus multilocularis	L aminoadipate semialdehyde	0.01	0.0079	0.0043
Brugia malayi	Pleckstrin Homology Domain	0.0112	0.0098	0.0098
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0112	0.0098	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0279	0.0359	0.6922
Brugia malayi	Variant SH3 domain containing protein	0.0112	0.0098	0.0098
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.0475	1
Chlamydia trachomatis	phospholipase D superfamily protein	0.1028	0.1535	0.5
Echinococcus granulosus	Pleckstrin y	0.0112	0.0098	0.0061
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0112	0.0098	0.0061
Schistosoma mansoni	oxysterol-binding protein 1	0.0112	0.0098	0.0061
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0112	0.0098	0.0179
Trypanosoma brucei	phosphatidylglycerolphosphate synthase, mitochondrial	0.1028	0.1535	0.4306
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0112	0.0098	0.0061
Entamoeba histolytica	phospholipase D active site domain-containing protein	0.5394	0.8386	0.837
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0112	0.0098	0.0061
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0112	0.0098	0.0061
Echinococcus granulosus	DCC interacting protein 13 beta	0.0112	0.0098	0.0061
Schistosoma mansoni	sorting nexin	0.0279	0.0359	0.0324
Echinococcus granulosus	sorting nexin	0.0279	0.0359	0.0324
Trypanosoma cruzi	PX domain containing protein, putative	0.0279	0.0359	0.0783
Trichomonas vaginalis	conserved hypothetical protein	0.0279	0.0359	0.6922
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0112	0.0098	0.0061
Trypanosoma brucei	PX domain containing protein, putative	0.0279	0.0359	0.0783
Brugia malayi	PH domain containing protein	0.0112	0.0098	0.0098
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0279	0.0359	0.0428
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.0475	1
Chlamydia trachomatis	phospholipase D endonuclease family protein	0.1028	0.1535	0.5
Brugia malayi	Phospholipase D. Active site motif family protein	0.224	0.3436	0.3436
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0279	0.0359	0.0428
Echinococcus multilocularis	ribosomal protein S6 kinase delta 1	0.0279	0.0359	0.0324
Onchocerca volvulus		0.0279	0.0359	0.1606
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0112	0.0098	0.0061
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0112	0.0098	0.0061
Trypanosoma brucei	differentiation inhibitory kinase	0.0279	0.0359	0.0783
Entamoeba histolytica	hypothetical protein	0.0279	0.0359	0.0264
Brugia malayi	Oxysterol-binding protein	0.0112	0.0098	0.0098
Onchocerca volvulus		0.0112	0.0098	0.0106
Echinococcus multilocularis	phospholipase D	0.5673	0.8824	0.882
Giardia lamblia	Fructose-bisphosphate aldolase	0.0353	0.0475	1
Echinococcus multilocularis	Pleckstrin y	0.0112	0.0098	0.0061
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.0475	1
Echinococcus multilocularis	sorting nexin	0.0279	0.0359	0.0324
Wolbachia endosymbiont of Brugia malayi	cardiolipin synthase	0.1028	0.1535	0.5
Brugia malayi	Oxysterol binding protein	0.0112	0.0098	0.0098
Trypanosoma cruzi	Autophagy-related protein 24	0.0279	0.0359	0.0783
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0112	0.0098	0.0061
Brugia malayi	PXA domain containing protein	0.0279	0.0359	0.0359
Leishmania major	protein kinase, putative	0.0112	0.0098	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Schistosoma mansoni	serine/threonine-protein kinase	0.0112	0.0098	0.0061
Echinococcus multilocularis		0.0279	0.0359	0.0324
Brugia malayi	Uncoordinated protein 104	0.0112	0.0098	0.0098
Toxoplasma gondii	AtPH1 family protein	0.0112	0.0098	0.0179
Toxoplasma gondii	hypothetical protein	0.0112	0.0098	0.0179
Echinococcus multilocularis	rac serine:threonine kinase	0.0112	0.0098	0.0061
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0112	0.0098	0.0179
Trypanosoma brucei	Autophagy-related protein 24	0.0279	0.0359	0.0783
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Loa Loa (eye worm)	syntrophin-1	0.0112	0.0098	0.0116
Echinococcus multilocularis	nischarin	0.0279	0.0359	0.0324
Toxoplasma gondii	protein kinase domain-containing protein	0.0112	0.0098	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.01	0.0079	0.0079
Echinococcus granulosus	Oxysterol binding protein 11	0.0112	0.0098	0.0061
Schistosoma mansoni	zinc finger protein	0.0112	0.0098	0.0061
Brugia malayi	Dynamin	0.0112	0.0098	0.0098
Brugia malayi	Cadps2 protein	0.0112	0.0098	0.0098
Echinococcus granulosus	nischarin	0.0279	0.0359	0.0324
Trypanosoma brucei	cardiolipin synthetase	0.224	0.3436	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0353	0.0475	0.5
Schistosoma mansoni	centaurin alpha	0.0112	0.0098	0.0061
Schistosoma mansoni	syntrophin	0.0112	0.0098	0.0061
Plasmodium vivax	phosphatidylglycerophosphate synthase, putative	0.1028	0.1535	1
Brugia malayi	Variant SH3 domain containing protein	0.0279	0.0359	0.0359
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0112	0.0098	0.0116
Brugia malayi	Dynamin	0.0112	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Schistosoma mansoni	rho gtpase activating protein	0.0112	0.0098	0.0061
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0112	0.0098	0.0116
Echinococcus multilocularis	sorting nexin 2	0.0279	0.0359	0.0324
Brugia malayi	PH domain containing protein	0.0112	0.0098	0.0098
Loa Loa (eye worm)	sorting nexin 12	0.0279	0.0359	0.0428
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0172	0.0192	0.0971
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.0475	1
Echinococcus multilocularis	Phox	0.0279	0.0359	0.0324
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0112	0.0098	0.0341
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0112	0.0098	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Mycobacterium tuberculosis	Probable oxidoreductase	0.1094	0.1639	1
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0112	0.0098	0.0116
Echinococcus multilocularis	sorting nexin 6	0.0279	0.0359	0.0324
Schistosoma mansoni	goodpasture antigen-binding protein	0.0112	0.0098	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0279	0.0359	0.0428
Echinococcus multilocularis	pdz domain containing protein	0.0112	0.0098	0.0061
Brugia malayi	PH domain containing protein	0.0112	0.0098	0.0098
Toxoplasma gondii	hypothetical protein	0.0112	0.0098	0.0179
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0112	0.0098	0.0061
Trypanosoma brucei	cardiolipin synthetase, putative	0.224	0.3436	1
Echinococcus granulosus	phospholipase d3	0.1211	0.1823	0.1793
Echinococcus granulosus	sorting nexin	0.0279	0.0359	0.0324
Echinococcus granulosus	sorting nexin 2	0.0279	0.0359	0.0324
Loa Loa (eye worm)	rho-GTPase-activating	0.0112	0.0098	0.0116
Brugia malayi	PX domain containing protein	0.0279	0.0359	0.0359
Loa Loa (eye worm)	uncoordinated protein 104	0.0112	0.0098	0.0116
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0112	0.0098	0.0061
Entamoeba histolytica	PX domain protein	0.0279	0.0359	0.0264
Echinococcus multilocularis	cytohesin 1	0.0112	0.0098	0.0061
Echinococcus granulosus	Pleckstrin y	0.0112	0.0098	0.0061
Echinococcus granulosus	pdz domain containing protein	0.0112	0.0098	0.0061
Toxoplasma gondii	Oxysterol-binding protein	0.0112	0.0098	0.0179
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0112	0.0098	0.0061
Entamoeba histolytica	hypothetical protein	0.0391	0.0535	0.0442
Echinococcus multilocularis	myotubularin protein 13	0.0112	0.0098	0.0061
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0112	0.0098	0.0061
Plasmodium falciparum	phosphoinositide-binding protein, putative	0.0279	0.0359	0.1819
Plasmodium vivax	hypothetical protein, conserved	0.0279	0.0359	0.1819
Echinococcus multilocularis	phospholipase d3	0.1211	0.1823	0.1793
Trypanosoma cruzi	Autophagy-related protein 24	0.0279	0.0359	0.0783
Chlamydia trachomatis	phospholipase D endonuclease family protein	0.1028	0.1535	0.5
Trypanosoma cruzi	cardiolipin synthetase, putative	0.224	0.3436	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0279	0.0359	0.0324
Plasmodium falciparum	phosphatidylglycerophosphate synthase	0.1028	0.1535	1
Echinococcus granulosus	beta 1 syntrophin	0.0112	0.0098	0.0061
Onchocerca volvulus		0.0279	0.0359	0.1606
Echinococcus granulosus	serine/threonine protein kinase	0.0112	0.0098	0.0061
Loa Loa (eye worm)	TRAF4-associated factor 2	0.0279	0.0359	0.0428
Entamoeba histolytica	hypothetical protein	0.0279	0.0359	0.0264
Schistosoma mansoni	hypothetical protein	0.0112	0.0098	0.0061
Brugia malayi	Syntrophin-1	0.0112	0.0098	0.0098
Brugia malayi	PX domain containing protein	0.0279	0.0359	0.0359
Plasmodium falciparum	mitochondrial cardiolipin synthase, putative	0.1028	0.1535	1
Trypanosoma cruzi	hypothetical protein	0.0279	0.0359	0.0783
Echinococcus granulosus	sorting nexin 6	0.0279	0.0359	0.0324
Trichomonas vaginalis	conserved hypothetical protein	0.0279	0.0359	0.6922
Brugia malayi	hypothetical protein	0.1028	0.1535	0.1535
Leishmania major	phosphoinositide-binding protein, putative	0.0279	0.0359	0.1806
Echinococcus granulosus	Rho GTPase activating protein 24	0.0112	0.0098	0.0061
Echinococcus granulosus	oxysterol binding protein 3	0.0112	0.0098	0.0061
Schistosoma mansoni	goodpasture antigen-binding protein	0.0112	0.0098	0.0061
Echinococcus granulosus	sorting nexin 13	0.0279	0.0359	0.0324
Schistosoma mansoni	hypothetical protein	0.0112	0.0098	0.0061
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.0475	0.0382
Trichomonas vaginalis	conserved hypothetical protein	0.0279	0.0359	0.6922
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0112	0.0098	0.0116
Schistosoma mansoni	jumonji domain containing protein	0.0092	0.0065	0.0029
Brugia malayi	Sorting nexin 12	0.0279	0.0359	0.0359
Schistosoma mansoni	dynamin	0.0112	0.0098	0.0061
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.0475	1
Brugia malayi	PX domain containing protein	0.0279	0.0359	0.0359
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.0036	0.0042
Leishmania major	protein kinase, putative	0.0112	0.0098	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0112	0.0098	0.0341
Loa Loa (eye worm)	PXA domain-containing protein	0.0279	0.0359	0.0428
Onchocerca volvulus	Protein melted homolog	0.0112	0.0098	0.0106
Schistosoma mansoni	vav2	0.0112	0.0098	0.0061
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0112	0.0098	0.0061
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0112	0.0098	0.0061
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0112	0.0098	0.0106
Schistosoma mansoni	hypothetical protein	0.0112	0.0098	0.0061
Schistosoma mansoni	myotubularin-related protein	0.0112	0.0098	0.0061
Schistosoma mansoni	growth factor receptor-bound protein	0.0112	0.0098	0.0061
Toxoplasma gondii	hypothetical protein	0.0279	0.0359	0.0949
Schistosoma mansoni	serine/threonine-protein kinase	0.0112	0.0098	0.0061
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0112	0.0098	0.0098
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0279	0.0359	0.0359
Loa Loa (eye worm)	hypothetical protein	0.01	0.0079	0.0094
Leishmania major	hypothetical protein, conserved	0.0112	0.0098	0.0341
Trichomonas vaginalis	conserved hypothetical protein	0.0279	0.0359	0.6922
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0112	0.0098	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Trypanosoma cruzi	hypothetical protein	0.0279	0.0359	0.0783
Echinococcus multilocularis	dynamin 1	0.0112	0.0098	0.0061
Brugia malayi	hypothetical protein	0.0112	0.0098	0.0098
Brugia malayi	PH domain containing protein	0.0112	0.0098	0.0098
Echinococcus multilocularis	oxysterol binding protein 3	0.0112	0.0098	0.0061
Loa Loa (eye worm)	cytohesin 3	0.0112	0.0098	0.0116
Onchocerca volvulus		0.0112	0.0098	0.0106
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0112	0.0098	0.0061
Chlamydia trachomatis	phospholipase D superfamily protein	0.1028	0.1535	0.5
Brugia malayi	PX domain containing protein	0.0279	0.0359	0.0359
Brugia malayi	probable spectrin beta chain	0.0112	0.0098	0.0098
Brugia malayi	Protein kinase domain containing protein	0.0112	0.0098	0.0098
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0112	0.0098	0.0061
Entamoeba histolytica	hypothetical protein	0.0279	0.0359	0.0264
Loa Loa (eye worm)	hypothetical protein	0.5394	0.8386	1
Echinococcus multilocularis	actin binding protein anillin	0.0112	0.0098	0.0061
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0112	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Schistosoma mansoni	hypothetical protein	0.0112	0.0098	0.0061
Trypanosoma cruzi	cardiolipin synthetase, putative	0.224	0.3436	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0172	0.0192	0.0971
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.01	0.0079	0.0043
Onchocerca volvulus		0.0112	0.0098	0.0106
Trypanosoma cruzi	hypothetical protein	0.0279	0.0359	0.0783
Echinococcus multilocularis	sorting nexin	0.0279	0.0359	0.0324
Echinococcus granulosus	sorting nexin 14	0.0279	0.0359	0.0324
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0115	0.0102	0.0066
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0112	0.0098	0.0106
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0279	0.0359	0.0949
Echinococcus granulosus	L aminoadipate semialdehyde	0.01	0.0079	0.0043
Loa Loa (eye worm)	PH domain-containing protein	0.0112	0.0098	0.0116
Trichomonas vaginalis	conserved hypothetical protein	0.0279	0.0359	0.6922
Brugia malayi	Protein K4	0.1028	0.1535	0.1535
Onchocerca volvulus		0.0112	0.0098	0.0106
Echinococcus granulosus	Pleckstrin y	0.0112	0.0098	0.0061
Echinococcus multilocularis	oxysterol binding protein 9	0.0112	0.0098	0.0061
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0112	0.0098	0.0061
Toxoplasma gondii	phospholipase D active site domain-containing protein	0.224	0.3436	1
Plasmodium falciparum	phosphoinositide-binding protein, putative	0.0279	0.0359	0.1819
Echinococcus multilocularis	sorting nexin 14	0.0279	0.0359	0.0324
Brugia malayi	Variant SH3 domain containing protein	0.0112	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.5394	0.8386	1
Loa Loa (eye worm)	hypothetical protein	0.4182	0.6485	0.7733
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0112	0.0098	0.0061
Brugia malayi	PH domain containing protein	0.0112	0.0098	0.0098
Chlamydia trachomatis	phospholipase D endonuclease family protein	0.1028	0.1535	0.5
Echinococcus granulosus	dynamin 1	0.0112	0.0098	0.0061
Onchocerca volvulus		0.0112	0.0098	0.0106
Brugia malayi	PXA domain containing protein	0.0279	0.0359	0.0359
Loa Loa (eye worm)	PX domain-containing protein	0.0279	0.0359	0.0428
Loa Loa (eye worm)	hypothetical protein	0.1211	0.1823	0.2173
Echinococcus multilocularis	sorting nexin 4	0.0279	0.0359	0.0324
Echinococcus granulosus	myotubularin protein 13	0.0112	0.0098	0.0061
Schistosoma mansoni	sorting nexin	0.0279	0.0359	0.0324
Leishmania major	folate/biopterin transporter, putative	0.0112	0.0098	0.0341
Echinococcus multilocularis	Pleckstrin y	0.0112	0.0098	0.0061
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0172	0.0192	0.5
Plasmodium vivax	cardiolipin synthetase, putative	0.1028	0.1535	1
Echinococcus multilocularis	Pleckstrin y	0.0112	0.0098	0.0061
Trypanosoma cruzi	PX domain containing protein, putative	0.0279	0.0359	0.0783
Mycobacterium ulcerans	short chain dehydrogenase	0.1094	0.1639	1
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Brugia malayi	TRAF4-associated factor 2	0.0279	0.0359	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Loa Loa (eye worm)	PX domain-containing protein	0.0279	0.0359	0.0428
Echinococcus granulosus	calcium dependent secretion activator 1	0.0112	0.0098	0.0061
Brugia malayi	Cytohesin 3	0.0112	0.0098	0.0098
Onchocerca volvulus	outspread protein homolog	0.0112	0.0098	0.0106
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0112	0.0098	0.0061
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0112	0.0098	0.0061
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0112	0.0098	0.0061
Chlamydia trachomatis	phospholipase D endonuclease family protein	0.1028	0.1535	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0279	0.0359	0.6922
Loa Loa (eye worm)	oxysterol binding protein	0.0112	0.0098	0.0116
Loa Loa (eye worm)	phospholipase D	0.1211	0.1823	0.2173
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Leishmania major	serine/threonine-protein kinase a, putative	0.0112	0.0098	0.0341
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0112	0.0098	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Loa Loa (eye worm)	hypothetical protein	0.1028	0.1535	0.1831
Echinococcus granulosus	oxysterol binding protein 1	0.0112	0.0098	0.0061
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0112	0.0098	0.0098
Schistosoma mansoni	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	0.1028	0.1535	0.1504
Loa Loa (eye worm)	hypothetical protein	0.0279	0.0359	0.0428
Echinococcus multilocularis	oxysterol binding protein 1	0.0112	0.0098	0.0061
Leishmania major	zinc finger protein kinase-like	0.0279	0.0359	0.1806
Trichomonas vaginalis	conserved hypothetical protein	0.0279	0.0359	0.6922
Echinococcus granulosus	Phox	0.0279	0.0359	0.0324
Leishmania major	hypothetical protein, conserved	0.0112	0.0098	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.0475	1
Leishmania major	cardiolipin synthetase, putative	0.1028	0.1535	0.839
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0115	0.0102	0.0066
Brugia malayi	Plekhf2 protein	0.0112	0.0098	0.0098
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.0475	1
Schistosoma mansoni	zinc finger protein	0.0112	0.0098	0.0061
Brugia malayi	jmjC domain containing protein	0.0115	0.0102	0.0102
Brugia malayi	MAX-1A	0.0112	0.0098	0.0098
Brugia malayi	TBC domain containing protein	0.0112	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Schistosoma mansoni	oxysterol-binding protein 1	0.0112	0.0098	0.0061
Echinococcus multilocularis	beta 1 syntrophin	0.0112	0.0098	0.0061
Loa Loa (eye worm)	PX domain-containing protein	0.0279	0.0359	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0098	0.0116
Onchocerca volvulus		0.0112	0.0098	0.0106
Echinococcus granulosus	ribosomal protein S6 kinase delta 1	0.0279	0.0359	0.0324
Onchocerca volvulus	Putative zinc finger protein	0.0112	0.0098	0.0106

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.7943 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	4.6535 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	10 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 15.8114 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ]	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1405873

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1295226