Detailed information for compound 1344687

Basic information

Technical information
  • TDR Targets ID: 1344687
  • Name: ZINC00148321
  • MW: 294.323 | Formula: C18H15FN2O
  • H donors: 1 H acceptors: 3 LogP: 3.87 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)Cc1cc(nnc1O)c1ccc(cc1)F
  • InChi: 1S/C18H15FN2O/c1-12-2-4-13(5-3-12)10-15-11-17(20-21-18(15)22)14-6-8-16(19)9-7-14/h2-9,11H,10H2,1H3,(H,21,22)
  • InChiKey: CPJXPVRFHXLPJV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_657781
  • 6-(4-fluorophenyl)-4-(4-methylbenzyl)-3(2H)-pyridazinone
  • MLS000850208
  • SMR000456226
  • HTS 04502

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0009 0 0.0001
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0135 0.0128
Brugia malayi MH2 domain containing protein 0.001 0.0003 0.0003
Brugia malayi Receptor family ligand binding region containing protein 0.0075 0.0218 0.0218
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0349 0.1126 0.166
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0349 0.1126 0.1126
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0348 1
Loa Loa (eye worm) Smad1 0.001 0.0003 0.0003
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0003 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0007 0.0059
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0007 0.001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0076 0.0112
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0007 0.0059
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0007 0.0059
Onchocerca volvulus 0.003 0.0069 0.0102
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0348 1
Onchocerca volvulus 0.0009 0 0.0001
Toxoplasma gondii hypothetical protein 0.0349 0.1126 1
Brugia malayi Smad1 0.001 0.0003 0.0003
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0349 0.1126 0.166
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0011 0.0007 0.0059
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0345 0.286
Onchocerca volvulus 0.0009 0 0.0001
Onchocerca volvulus 0.0009 0 0.0001
Plasmodium vivax glutathione reductase, putative 0.005 0.0135 0.0979
Loa Loa (eye worm) phosphofructokinase 0.0114 0.0348 0.0348
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0003 0.0003
Brugia malayi Guanylyl cyclase protein 23 0.0075 0.0218 0.0218
Schistosoma mansoni glutamate receptor AMPA 0.0146 0.0453 0.0668
Schistosoma mansoni hypothetical protein 0.0426 0.138 0.2036
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0554 0.6442
Leishmania major extracellular receptor, putative 0.0075 0.0218 0.0211
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0036 0.0077
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0348 0.4048
Trypanosoma cruzi extracellular receptor, putative 0.0075 0.0218 0.0211
Brugia malayi Pre-SET motif family protein 0.0219 0.0696 0.0696
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0007 0.001
Onchocerca volvulus 0.0009 0 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0072 0.084
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0349 0.1126 0.166
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0072 0.0383
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0027 0.0039
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0109 0.016
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0072 0.1175
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0036 0.0029
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0109 0.016
Loa Loa (eye worm) hypothetical protein 0.0075 0.0218 0.0218
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0146 0.0453 0.0668
Trichomonas vaginalis set domain proteins, putative 0.025 0.0796 0.9256
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0554 0.6442
Schistosoma mansoni sodium/chloride dependent transporter 0.2057 0.6778 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.0348 0.0476
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0586 0.6807
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0349 0.1126 0.166
Brugia malayi Receptor family ligand binding region containing protein 0.0075 0.0218 0.0218
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0135 0.0198
Onchocerca volvulus 0.0009 0 0.0001
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0072 0.0383
Brugia malayi MH1 domain containing protein 0.001 0.0003 0.0003
Schistosoma mansoni tyrosine kinase 0.0075 0.0218 0.0321
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0348 0.0513
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0007 0.0059
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0005 0.0006
Plasmodium vivax hypothetical protein, conserved 0.0349 0.1126 1
Schistosoma mansoni metabotropic glutamate receptor 0.0075 0.0218 0.0321
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0027 0.002
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0349 0.1126 0.166
Echinococcus granulosus cpg binding protein 0.0032 0.0075 0.011
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0349 0.1126 0.166
Schistosoma mansoni cpg binding protein 0.003 0.0069 0.0101
Brugia malayi hypothetical protein 0.0075 0.0218 0.0218
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0349 0.1126 0.1126
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0374 0.1208 1
Loa Loa (eye worm) hypothetical protein 0.2057 0.6778 0.6778
Onchocerca volvulus 0.0075 0.0218 0.0321
Onchocerca volvulus 0.0075 0.0218 0.0321
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.0348 0.0341
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0005 0.0006
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0011 0.0007 0.0059
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0072 0.084
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.086 1
Loa Loa (eye worm) hypothetical protein 0.0349 0.1126 0.1126
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0007 0.0059
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0349 0.1126 0.1126
Schistosoma mansoni cpg binding protein 0.0032 0.0075 0.011
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0076 0.0112
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0072 0.0411
Loa Loa (eye worm) hypothetical protein 0.0349 0.1126 0.1126
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0007 0.0059
Onchocerca volvulus 0.0009 0 0.0001
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0089 0.1034
Brugia malayi Glutamate receptor 2 precursor 0.0146 0.0453 0.0453
Trypanosoma cruzi C-8 sterol isomerase, putative 0.303 1 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.0348 0.8975
Echinococcus multilocularis receptor type guanylyl cyclase 0.0075 0.0218 0.0321
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0003 0.0003
Echinococcus granulosus receptor type guanylyl cyclase 0.0075 0.0218 0.0321
Echinococcus multilocularis Smad4 0.001 0.0003 0.0003
Echinococcus granulosus atrial natriuretic peptide receptor 0.0075 0.0218 0.0321
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0007 0.0059
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0348 0.0341
Brugia malayi CXXC zinc finger family protein 0.003 0.0069 0.0069
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0345 0.8899
Schistosoma mansoni smad1 5 8 and 0.001 0.0003 0.0003
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0027 0.0179
Loa Loa (eye worm) glutamate receptor 0.0075 0.0218 0.0218
Loa Loa (eye worm) solute carrier family 6 member 4 0.2057 0.6778 0.6778
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0027 0.0225
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0036 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0349 0.1126 0.166
Schistosoma mansoni hypothetical protein 0.0146 0.0453 0.0668
Onchocerca volvulus 0.0009 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0349 0.1126 0.1126
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0011 0.0007 0.0059
Echinococcus multilocularis glutamate receptor 2 0.0075 0.0218 0.0321
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0072 0.0411
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0072 0.0411
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.086 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0007 0.0059
Echinococcus multilocularis smad 0.001 0.0003 0.0003
Brugia malayi Glutamate receptor 1 precursor 0.0146 0.0453 0.0453
Schistosoma mansoni metabotropic glutamate receptor 0.0075 0.0218 0.0321
Schistosoma mansoni glutamate receptor NMDA 0.0146 0.0453 0.0668
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0349 0.1126 0.166
Plasmodium vivax SET domain protein, putative 0.0032 0.0076 0.0446
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0011 0.0007 0.0059
Loa Loa (eye worm) hypothetical protein 0.303 1 1
Echinococcus granulosus nmda type glutamate receptor 0.052 0.169 0.2494
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0348 1
Brugia malayi MH1 domain containing protein 0.001 0.0003 0.0003
Schistosoma mansoni sodium-dependent amino acid transporter 0.0349 0.1126 0.166
Echinococcus multilocularis glutamate receptor 2 0.0146 0.0453 0.0668
Echinococcus multilocularis neuropeptide receptor A26 0.0488 0.1586 0.234
Echinococcus multilocularis nmda type glutamate receptor 0.0075 0.0218 0.0321
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0349 0.1126 0.1126
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.2057 0.6778 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.0348 0.2884
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0076 0.0112
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0027 0.0315
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0554 0.6442
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0011 0.0007 0.0059
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0036 0.0295
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0036 0.0295
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0003 0.0003
Echinococcus granulosus sodium and chloride dependent glycine 0.0349 0.1126 0.166
Leishmania major cytochrome p450-like protein 0.002 0.0038 0.0031
Onchocerca volvulus 0.2057 0.6778 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Brugia malayi hypothetical protein 0.0128 0.0394 0.0394
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0007 0.001
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0027 0.3754
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0011 0.0007 0.0059
Echinococcus multilocularis tyrosine kinase 0.0075 0.0218 0.0321
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0038 0.0031
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0027 0.002
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0072 0.084
Treponema pallidum sodium- and chloride- dependent transporter 0.2057 0.6778 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0036 0.0413
Brugia malayi Cytochrome P450 family protein 0.0031 0.0073 0.0073
Brugia malayi Metabotropic glutamate receptor precursor. 0.0075 0.0218 0.0218
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0027 0.002
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0221 0.07 0.1033
Schistosoma mansoni ap endonuclease 0.002 0.0036 0.0052
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0007 0.0059
Brugia malayi Pre-SET motif family protein 0.0032 0.0076 0.0076
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0221 0.07 0.1033
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.2729 0.4026
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0072 0.084
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0011 0.0007 0.0059
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0097 0.0097
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.0348 0.0513
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0349 0.1126 0.9306
Brugia malayi Sodium:neurotransmitter symporter family protein 0.2057 0.6778 0.6778
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0011 0.0007 0.0059
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0349 0.1126 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0072 0.0583
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0011 0.0007 0.0059
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0374 0.1208 0.1749
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0348 0.0341
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0075 0.0218 0.0321
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0075 0.0218 0.0321
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0007 0.0059
Schistosoma mansoni cytochrome P450 0.0011 0.0007 0.001
Loa Loa (eye worm) RGC/RGC protein kinase 0.0075 0.0218 0.0218
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0349 0.1126 0.166
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0374 0.1208 1
Echinococcus multilocularis serotonin transporter 0.2057 0.6778 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0221 0.07 0.1033
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0027 0.002
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0036 0.0077
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0221 0.07 0.1033
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0027 0.002
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0135 0.1115
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0027 0.002
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0027 0.002
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0011 0.0007 0.0059
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0089 0.1034
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0072 0.0411
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0072 0.0583
Brugia malayi MH2 domain containing protein 0.0144 0.0447 0.0447
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0027 0.002
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0348 0.0348
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0221 0.07 0.1033
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0135 0.0135
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0036 0.0029
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0011 0.0007 0.0059
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0027 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0554 0.6442
Entamoeba histolytica hypothetical protein 0.0075 0.0218 0.5822
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0345 0.286
Schistosoma mansoni tyrosine kinase 0.0075 0.0218 0.0321
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0027 0.0027
Brugia malayi 6-phosphofructokinase 0.0114 0.0348 0.0348
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0009 0 0.0001
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0135 0.0979
Echinococcus granulosus smad 0.001 0.0003 0.0003
Brugia malayi phosphofructokinase 0.0114 0.0348 0.0348
Echinococcus granulosus microtubule associated protein 2 0.0833 0.2729 0.4026
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0027 0.0315
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0251 0.0801 0.0801
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0076 0.0618
Echinococcus multilocularis sodium and chloride dependent glycine 0.0349 0.1126 0.166
Echinococcus multilocularis cpg binding protein 0.0032 0.0075 0.011
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0345 0.286
Loa Loa (eye worm) hypothetical protein 0.0075 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.2057 0.6778 0.6778
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0221 0.07 0.1033
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0011 0.0007 0.0059
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0075 0.0218 0.0218
Echinococcus granulosus metabotropic glutamate receptor 5 0.0075 0.0218 0.0321
Onchocerca volvulus 0.0009 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0075 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0075 0.0218 0.0218
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0076 0.0112
Trypanosoma brucei C-8 sterol isomerase, putative 0.303 1 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0011 0.0007 0.0059
Toxoplasma gondii exonuclease III APE 0.002 0.0036 0.0255
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0146 0.0453 0.0668
Loa Loa (eye worm) hypothetical protein 0.0033 0.0081 0.0081
Schistosoma mansoni sodium/chloride dependent transporter 0.0349 0.1126 0.166
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0011 0.0007 0.0059
Echinococcus multilocularis 0.0011 0.0007 0.001
Onchocerca volvulus 0.0009 0 0.0001
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0146 0.0453 0.0668
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0012 0.0012
Schistosoma mansoni cpg binding protein 0.0032 0.0075 0.011
Brugia malayi hypothetical protein 0.0349 0.1126 0.1126
Echinococcus granulosus nmda type glutamate receptor 0.0075 0.0218 0.0321
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0027 0.002
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0075 0.0218 0.0218
Loa Loa (eye worm) RGC/RGC protein kinase 0.0075 0.0218 0.0218
Schistosoma mansoni protein kinase 0.0075 0.0218 0.0321
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0072 1
Leishmania major trypanothione reductase 0.005 0.0135 0.0128
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0003 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0007 0.0059
Plasmodium falciparum amino acid transporter, putative 0.0349 0.1126 1
Echinococcus multilocularis glutamate receptor 2 0.0221 0.07 0.1033
Loa Loa (eye worm) CYP4Cod1 0.002 0.0038 0.0038
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0075 0.0218 0.0321
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0349 0.1126 0.166
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0027 0.0039
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.0696 0.0696
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0038 0.0038
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0221 0.07 0.1033
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0007 0.001
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0075 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.2057 0.6778 0.6778
Echinococcus granulosus tyrosine kinase 0.0075 0.0218 0.0321
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0075 0.0218 0.0321
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0027 0.0225
Brugia malayi MH2 domain containing protein 0.001 0.0003 0.0003
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.1549 0.5097 0.5097
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0027 0.0179
Schistosoma mansoni smad 0.001 0.0003 0.0003
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0027 0.0039
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0072 0.084
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0012 0.0012
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0349 0.1126 0.166
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0554 0.6442
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0349 0.1126 1
Plasmodium falciparum glutathione reductase 0.005 0.0135 0.0979
Echinococcus granulosus serotonin transporter 0.2057 0.6778 1
Brugia malayi metabotropic glutamate receptor type 2 0.0075 0.0218 0.0218
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0007 0.001
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0003 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.086 1
Onchocerca volvulus 0.0009 0 0.0001
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.0387 0.3207
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0007 0.0059
Echinococcus multilocularis dnaJ subfamily B 0.0426 0.138 0.2036
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0269 0.086 0.086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0027 0.002
Loa Loa (eye worm) hypothetical protein 0.0349 0.1126 0.1126
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.086 1
Chlamydia trachomatis glutamine binding protein 0.0374 0.1208 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0097 0.0143
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0374 0.1208 0.1749
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0003 0.0003
Loa Loa (eye worm) cytochrome P450 0.0011 0.0007 0.0007
Onchocerca volvulus 0.0032 0.0076 0.0112
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0038 0.0311
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0011 0.0007 0.0059
Loa Loa (eye worm) hypothetical protein 0.0075 0.0218 0.0218
Echinococcus granulosus metabotropic glutamate receptor 2 0.0075 0.0218 0.0321
Echinococcus granulosus neuropeptide receptor A26 0.0488 0.1586 0.234
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.007 0.0103
Loa Loa (eye worm) hypothetical protein 0.0032 0.0076 0.0076
Leishmania major C-8 sterol isomerase-like protein 0.303 1 1
Schistosoma mansoni Smad4 0.001 0.0003 0.0003
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0036 0.0413
Onchocerca volvulus 0.0009 0 0.0001
Onchocerca volvulus Neuropeptide F receptor homolog 0.0009 0 0.0001
Loa Loa (eye worm) RGC/RGC protein kinase 0.0075 0.0218 0.0218
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0011 0.0007 0.0059
Loa Loa (eye worm) hypothetical protein 0.0349 0.1126 0.1126
Loa Loa (eye worm) glutamate receptor 2 0.0146 0.0453 0.0453
Loa Loa (eye worm) hypothetical protein 0.0349 0.1126 0.1126
Schistosoma mansoni ATP-binding cassette transporter 0.0146 0.0453 0.0668
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0007 0.0007
Brugia malayi Cytochrome P450 family protein 0.002 0.0038 0.0038
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0146 0.0453 0.0668
Echinococcus granulosus glutamate NMDA receptor subunit 0.0146 0.0453 0.0668
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0184 0.0271
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0348 0.4048
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0349 0.1126 0.1126
Echinococcus granulosus Smad4 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0075 0.0218 0.0218
Brugia malayi cytochrome P450 0.0011 0.0007 0.0007
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0007 0.0059
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0135 0.0198
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0349 0.1126 0.166
Echinococcus multilocularis sodium and chloride dependent glycine 0.0349 0.1126 0.166
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0036 0.4919
Echinococcus granulosus glutamate receptor 2 0.0221 0.07 0.1033
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0036 0.0012
Brugia malayi follicle stimulating hormone receptor 0.0251 0.0801 0.0801
Loa Loa (eye worm) glutamate receptor 1 0.0146 0.0453 0.0453
Loa Loa (eye worm) hypothetical protein 0.0075 0.0218 0.0218
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0038 0.0031
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.0387 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0036 0.0029
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0349 0.1126 0.166
Schistosoma mansoni sodium/chloride dependent transporter 0.0349 0.1126 0.166
Echinococcus granulosus glutamate receptor subunit protein glur 0.0146 0.0453 0.0668
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0069 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.086 1
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0348 0.4048
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0027 0.002
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0072 0.0583
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0072 0.084
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0075 0.0218 0.0218
Schistosoma mansoni smad1 5 8 and 0.001 0.0003 0.0003
Brugia malayi Cytochrome P450 family protein 0.0011 0.0007 0.0007
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0007 0.0059
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0027 0.0225
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0007 0.0059
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0011 0.0007 0.0059
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0027 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0554 0.6442
Schistosoma mansoni glutamate receptor NMDA 0.0221 0.07 0.1033
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0349 0.1126 0.1126
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0036 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0076 0.0112
Loa Loa (eye worm) histone methyltransferase 0.001 0.0005 0.0005
Onchocerca volvulus 0.0349 0.1126 0.1661
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0011 0.0007 0.0059
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0072 0.0067
Echinococcus granulosus sodium and chloride dependent glycine 0.0349 0.1126 0.166
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.0387 0.3207
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0586 0.6807
Plasmodium falciparum thioredoxin reductase 0.005 0.0135 0.0979
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0027 0.002
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0146 0.0453 0.0668
Brugia malayi Thioredoxin reductase 0.005 0.0135 0.0135
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0036 0.0036
Toxoplasma gondii thioredoxin reductase 0.005 0.0135 0.114
Trypanosoma brucei cytochrome P450, putative 0.002 0.0038 0.0031
Toxoplasma gondii hypothetical protein 0.0349 0.1126 1
Loa Loa (eye worm) hypothetical protein 0.0333 0.1074 0.1074
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0349 0.1126 0.166
Echinococcus multilocularis NMDA receptor 0.0146 0.0453 0.0668
Loa Loa (eye worm) hypothetical protein 0.0349 0.1126 0.1126
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.0348 0.0513
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.052 0.169 0.2494
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0348 0.0348
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0146 0.0453 0.0668
Onchocerca volvulus 0.0009 0 0.0001
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0097 0.0143
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0349 0.1126 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0072 0.084
Schistosoma mansoni smad1 5 8 and 0.001 0.0003 0.0003
Schistosoma mansoni glutamate receptor AMPA 0.0146 0.0453 0.0668
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.0554 0.0818
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0447 0.0447
Brugia malayi Cytochrome P450 family protein 0.002 0.0038 0.0038
Onchocerca volvulus 0.0009 0 0.0001
Schistosoma mansoni ap endonuclease 0.002 0.0036 0.0052
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0007 0.0059
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0162 0.1381
Echinococcus granulosus neuropeptide s receptor 0.0488 0.1586 0.234
Schistosoma mansoni glutamate receptor kainate 0.0146 0.0453 0.0668
Echinococcus granulosus glutamate receptor 2 0.0075 0.0218 0.0321
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.2729 0.4026
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0027 0.002
Brugia malayi glutathione reductase 0.005 0.0135 0.0135
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0007 0.0059
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0269 0.086 0.086
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0027 0.0225
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0007 0.0059
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0345 0.286
Onchocerca volvulus 0.0349 0.1126 0.1661
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0374 0.1208 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0007 0.0059
Schistosoma mansoni glutamate receptor kainate 0.0146 0.0453 0.0668
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0447 0.0447
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0073 0.0073
Plasmodium falciparum transporter, putative 0.0349 0.1126 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0027 0.002
Onchocerca volvulus 0.0009 0 0.0001
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0036 0.0036
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0007 0.001
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0348 0.4048
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0554 0.6442
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.0348 0.2884
Onchocerca volvulus 0.0009 0 0.0001
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.001
Loa Loa (eye worm) glutathione reductase 0.005 0.0135 0.0135
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0011 0.0007 0.0059
Mycobacterium tuberculosis Probable reductase 0.0113 0.0345 0.286
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0075 0.0218 0.0218
Brugia malayi 6-phosphofructokinase 0.0114 0.0348 0.0348
Trypanosoma brucei trypanothione reductase 0.005 0.0135 0.0128
Echinococcus multilocularis neuropeptide s receptor 0.0488 0.1586 0.234
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0038 0.0038
Echinococcus multilocularis nmda type glutamate receptor 0.052 0.169 0.2494
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0027 0.002
Onchocerca volvulus 0.025 0.0796 0.1175
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.0387 0.3207
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0345 0.286
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0076 0.0112
Loa Loa (eye worm) hypothetical protein 0.0075 0.0218 0.0218
Schistosoma mansoni glutamate receptor kainate 0.0146 0.0453 0.0668
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0076 0.0112
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0348 0.0513
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0146 0.0453 0.0668
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0011 0.0007 0.0059
Onchocerca volvulus 0.0009 0 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0007 0.0059
Onchocerca volvulus 0.0349 0.1126 0.1661
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0221 0.07 0.1033
Echinococcus granulosus dnaJ subfamily B 0.0426 0.138 0.2036
Loa Loa (eye worm) norepinephrine transporter 0.2057 0.6778 0.6778
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.086 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0349 0.1126 0.166
Loa Loa (eye worm) serotonin transporter b 0.2057 0.6778 0.6778
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0004 0.0004
Plasmodium vivax amine transporter, putative 0.0349 0.1126 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0036 0.0052
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0036 0.0029

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.4125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Saccharomyces cerevisiae ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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