Detailed information for compound 1371292

Basic information

Technical information
  • TDR Targets ID: 1371292
  • Name: N-[(4-methylphenyl)methyl]-1-[(4-methylsulfan ylphenyl)methyl]piperidine-4-carboxamide; oxa lic acid
  • MW: 458.57 | Formula: C24H30N2O5S
  • H donors: 3 H acceptors: 5 LogP: 1.37 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(=O)O.CSc1ccc(cc1)CN1CCC(CC1)C(=O)NCc1ccc(cc1)C
  • InChi: 1S/C22H28N2OS.C2H2O4/c1-17-3-5-18(6-4-17)15-23-22(25)20-11-13-24(14-12-20)16-19-7-9-21(26-2)10-8-19;3-1(4)2(5)6/h3-10,20H,11-16H2,1-2H3,(H,23,25);(H,3,4)(H,5,6)
  • InChiKey: DFFYXUJRYUBYNM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(4-methylphenyl)methyl]-1-[[4-(methylthio)phenyl]methyl]-4-piperidinecarboxamide; oxalic acid
  • N-(4-methylbenzyl)-1-[4-(methylthio)benzyl]isonipecotamide; oxalic acid
  • ethanedioic acid; N-[(4-methylphenyl)methyl]-1-[(4-methylsulfanylphenyl)methyl]piperidine-4-carboxamide
  • MLS000718322
  • SMR000290590

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase, putative 0.0227 0.0319 0.1855
Schistosoma mansoni serine/threonine protein kinase 0.0576 0.1224 0.3522
Trichomonas vaginalis STE family protein kinase 0.0693 0.1526 1
Brugia malayi Guanylyl cyclase protein 23 0.0114 0.0027 0.0027
Trichomonas vaginalis CK1 family protein kinase 0.0271 0.0434 0.272
Schistosoma mansoni protein kinase 0.0416 0.081 0.233
Leishmania major protein kinase, putative 0.0425 0.0833 0.3485
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0134 0.0079 0.0089
Echinococcus granulosus casein kinase I alpha 0.0271 0.0434 0.0951
Entamoeba histolytica protein kinase domain containing protein 0.0144 0.0105 0.0495
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.1008 0.234 1
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.0145 0.0418
Brugia malayi Pre-SET motif family protein 0.0251 0.0383 0.0383
Echinococcus multilocularis tyrosine kinase 0.0114 0.0027 0.003
Brugia malayi hypothetical protein 0.0114 0.0027 0.0027
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0555 0.1169 0.2559
Trypanosoma cruzi casein kinase, putative 0.0271 0.0434 0.1763
Schistosoma mansoni serine/threonine protein kinase 0.0227 0.0319 0.0918
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0425 0.0833 0.5377
Echinococcus multilocularis PAK box P21 Rho binding 0.0134 0.0079 0.0089
Echinococcus multilocularis neuroglian 0.0393 0.075 0.0852
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0398 0.1603
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0114 0.0027 0.0027
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0322 0.0566 0.4504
Echinococcus granulosus fibroblast growth factor receptor 4 0.0532 0.1108 0.2425
Schistosoma mansoni serine/threonine protein kinase 0.0322 0.0566 0.1628
Echinococcus granulosus retinal guanylyl cyclase 2 0.0114 0.0027 0.0058
Trypanosoma brucei aurora B kinase 0.0425 0.0833 0.3485
Schistosoma mansoni titin 0.0139 0.0093 0.0268
Echinococcus multilocularis FL cytokine receptor 0.0114 0.0027 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0163 0.0154 0.0848
Echinococcus granulosus activated cdc42 kinase 1 0.0814 0.1838 0.4023
Loa Loa (eye worm) TK protein kinase 0.0268 0.0426 0.0426
Echinococcus granulosus tyrosine protein kinase shark 0.0201 0.0252 0.0552
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0753 0.168 0.3677
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0416 0.081 0.081
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0326 0.0575 0.0575
Echinococcus granulosus defective proboscis extension response 0.0305 0.0522 0.1143
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0227 0.0319 0.0362
Onchocerca volvulus 0.0201 0.0252 0.0252
Echinococcus multilocularis tyrosine protein kinase ABL1 0.1075 0.2515 0.2857
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.029 0.0833
Entamoeba histolytica cell division protein kinase 2, putative 0.0298 0.0505 0.3036
Loa Loa (eye worm) TK/ROR protein kinase 0.0201 0.0254 0.0254
Echinococcus multilocularis tyrosine protein kinase Blk 0.0355 0.0652 0.0741
Trichomonas vaginalis STE family protein kinase 0.0134 0.0079 0.0347
Loa Loa (eye worm) hypothetical protein 0.0149 0.0119 0.0119
Entamoeba histolytica protein kinase, putative 0.0175 0.0187 0.1015
Brugia malayi serine/threonine protein kinase 6 0.0425 0.0833 0.0833
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0646 0.413
Loa Loa (eye worm) hypothetical protein 0.0448 0.0892 0.0892
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1984 0.4865 0.4865
Onchocerca volvulus 0.0314 0.0545 0.0545
Echinococcus granulosus cyclin dependent kinase 9 0.0181 0.0201 0.044
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0027 0.0077
Schistosoma mansoni tyrosine kinase 0.0201 0.0252 0.0726
Echinococcus multilocularis dual specificity protein kinase clk2 0.0576 0.1224 0.1391
Schistosoma mansoni serine/threonine protein kinase 0.0569 0.1205 0.3468
Echinococcus granulosus dual specificity 0.0723 0.1602 0.3508
Echinococcus granulosus roundabout 2 0.0459 0.0921 0.2017
Schistosoma mansoni tyrosine kinase 0.0114 0.0027 0.0077
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0163 0.0154 0.055
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0422 0.0825 0.0825
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0114 0.0027 0.0077
Schistosoma mansoni tyrosine kinase 0.0664 0.1452 0.4176
Brugia malayi Immunoglobulin I-set domain containing protein 0.062 0.1336 0.1336
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0163 0.0154 0.055
Echinococcus multilocularis Immunoglobulin 0.0305 0.0522 0.0593
Onchocerca volvulus 0.0471 0.0952 0.0952
Brugia malayi Protein kinase domain containing protein 0.1463 0.3517 0.3517
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.1043 0.2431 0.2431
Echinococcus granulosus casein kinase I delta 0.0271 0.0434 0.0951
Brugia malayi plexin A 0.0142 0.01 0.01
Schistosoma mansoni protein kinase 0.0114 0.0027 0.0077
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0693 0.1526 0.6482
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.012 0.0044 0.005
Echinococcus granulosus protein kinase c iota type 0.0215 0.029 0.0634
Brugia malayi hypothetical protein 0.032 0.0561 0.0561
Schistosoma mansoni nck2/grb4 0.0152 0.0125 0.036
Echinococcus granulosus tyrosine protein kinase Fyn 0.042 0.0818 0.1791
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0114 0.0027 0.0077
Schistosoma mansoni growth factor receptor-bound protein 0.0158 0.0142 0.041
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0227 0.0319 0.0698
Brugia malayi Protein kinase domain containing protein 0.0326 0.0575 0.0575
Schistosoma mansoni tyrosine kinase 0.042 0.0818 0.2354
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0392 0.0747 0.0747
Echinococcus multilocularis activated cdc42 kinase 1 0.0814 0.1838 0.2088
Schistosoma mansoni serine/threonine protein kinase 0.0336 0.0602 0.1733
Loa Loa (eye worm) AUR protein kinase 0.0425 0.0833 0.0833
Schistosoma mansoni septate junction protein 0.0139 0.0093 0.0268
Schistosoma mansoni serine/threonine protein kinase 0.0163 0.0154 0.0443
Loa Loa (eye worm) hypothetical protein 0.0114 0.0027 0.0027
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0114 0.0027 0.003
Echinococcus granulosus activated cdc42 kinase 1 0.0814 0.1838 0.4023
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0775 0.1738 0.1738
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0723 0.1602 0.1602
Echinococcus multilocularis mitogen activated protein kinase 14 0.1008 0.234 0.2658
Loa Loa (eye worm) CAMK protein kinase 0.0171 0.0175 0.0175
Leishmania major protein kinase, putative 0.0576 0.1224 0.5176
Entamoeba histolytica protein kinase domain containing protein 0.0181 0.0201 0.1108
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0164 0.0157 0.0157
Brugia malayi Protein kinase domain containing protein 0.0201 0.0252 0.0252
Brugia malayi hypothetical protein 0.0258 0.0401 0.0401
Loa Loa (eye worm) TK/ABL protein kinase 0.1075 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0152 0.0125 0.0125
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Echinococcus granulosus twitchin 0.046 0.0924 0.2023
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0114 0.0027 0.0027
Loa Loa (eye worm) IKK protein kinase 0.3969 1 1
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Echinococcus multilocularis beta adrenergic receptor kinase 0.0122 0.0048 0.0054
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0466 0.0939 0.2056
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0646 0.393
Schistosoma mansoni hypothetical protein 0.0205 0.0262 0.0755
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0181 0.0201 0.1458
Schistosoma mansoni serine/threonine protein kinase 0.0164 0.0157 0.0453
Echinococcus multilocularis hemicentin 1 0.0139 0.0093 0.0106
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0134 0.0079 0.0089
Loa Loa (eye worm) hypothetical protein 0.032 0.0561 0.0561
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0425 0.0833 0.1823
Trichomonas vaginalis AGC family protein kinase 0.0425 0.0833 0.5377
Trichomonas vaginalis CAMK family protein kinase 0.0163 0.0154 0.0848
Echinococcus multilocularis tyrosine protein kinase Abl 0.0599 0.1284 0.1458
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0646 0.413
Echinococcus multilocularis roundabout 2 0.0154 0.0132 0.015
Entamoeba histolytica tyrosin kinase, putative 0.0144 0.0105 0.0495
Entamoeba histolytica protein kinase , putative 0.0425 0.0833 0.5116
Schistosoma mansoni tyrosine kinase 0.0664 0.1452 0.4176
Trichomonas vaginalis CMGC family protein kinase 0.0298 0.0505 0.3191
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0723 0.1602 0.6813
Giardia lamblia Kinase, STE STE20 0.0693 0.1526 1
Schistosoma mansoni rap gtpase-activating protein 0.0213 0.0284 0.0816
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.1008 0.234 0.234
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.0646 0.413
Leishmania major protein kinase A catalytic subunit isoform 1 0.0322 0.0566 0.2331
Echinococcus granulosus hemicentin 1 0.0139 0.0093 0.0204
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Echinococcus granulosus Immunoglobulin 0.0305 0.0522 0.1143
Brugia malayi MH2 domain containing protein 0.0144 0.0106 0.0106
Echinococcus multilocularis casein kinase I alpha 0.0271 0.0434 0.0494
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0322 0.0566 0.4504
Loa Loa (eye worm) hypothetical protein 0.0307 0.0526 0.0526
Plasmodium falciparum glycogen synthase kinase 3 0.0471 0.0952 0.7725
Giardia lamblia Kinase, AGC AKT 0.0422 0.0825 0.5325
Schistosoma mansoni protein tyrosine kinase 0.0114 0.0027 0.0077
Brugia malayi cell division control protein 2 homolog 0.0298 0.0505 0.0505
Plasmodium vivax serine/threonine kinase-1, putative 0.0576 0.1224 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0093 0.0093
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0227 0.0319 0.2441
Schistosoma mansoni tyrosine kinase 0.0114 0.0027 0.0077
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0569 0.1205 0.2638
Echinococcus multilocularis heat shock protein 70 0.0114 0.0027 0.003
Schistosoma mansoni vav2 0.0159 0.0144 0.0415
Brugia malayi Tyrosine-protein kinase abl-1 0.0599 0.1284 0.1284
Loa Loa (eye worm) hypothetical protein 0.0655 0.1428 0.1428
Trypanosoma cruzi casein kinase, putative 0.0271 0.0434 0.1763
Trichomonas vaginalis CAMK family protein kinase 0.0163 0.0154 0.0848
Echinococcus granulosus plexin a4 0.0142 0.01 0.0218
Toxoplasma gondii casein kinase I 0.0271 0.0434 0.3406
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.018 0.0198 0.1428
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Schistosoma mansoni protein kinase 0.0114 0.0027 0.0077
Trichomonas vaginalis STE family protein kinase 0.0134 0.0079 0.0347
Loa Loa (eye worm) hypothetical protein 0.0139 0.0093 0.0093
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0154 0.0132 0.015
Trichomonas vaginalis CAMK family protein kinase 0.0163 0.0154 0.0848
Trichomonas vaginalis AGC family protein kinase 0.0175 0.0187 0.1067
Schistosoma mansoni protein kinase 0.0114 0.0027 0.0077
Loa Loa (eye worm) TK/Met protein kinase 0.0114 0.0027 0.0027
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0322 0.0566 0.2331
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.028 0.0458 0.1003
Schistosoma mansoni plexin 0.0112 0.0021 0.0062
Loa Loa (eye worm) AUR protein kinase 0.0425 0.0833 0.0833
Schistosoma mansoni protein kinase 0.037 0.0691 0.1987
Brugia malayi SRC-1 0.042 0.0818 0.0818
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0031 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0163 0.0154 0.0443
Leishmania major hypothetical protein, conserved 0.0257 0.0398 0.1603
Brugia malayi protein C17H12.11 0.0258 0.0401 0.0401
Giardia lamblia Kinase, CMGC CDK 0.0298 0.0505 0.3191
Loa Loa (eye worm) TK/CSK protein kinase 0.0114 0.0027 0.0027
Brugia malayi Protein kinase domain containing protein 0.0123 0.0052 0.0052
Echinococcus granulosus dual specificity protein kinase clk2 0.0576 0.1224 0.2679
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0152 0.0125 0.0125
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0134 0.0079 0.0172
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0227 0.0319 0.1264
Echinococcus granulosus tyrosine protein kinase Srms 0.0201 0.0252 0.0552
Brugia malayi Protein kinase domain containing protein 0.0201 0.0252 0.0252
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0227 0.0319 0.0362
Onchocerca volvulus 0.0182 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0489 0.0998 0.0998
Onchocerca volvulus 0.0213 0.0284 0.0284
Echinococcus granulosus tyrosine protein kinase csk 0.0114 0.0027 0.0058
Echinococcus multilocularis protein tyrosine kinase 0.1447 0.3476 0.3949
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0227 0.0319 0.0698
Schistosoma mansoni protein kinase 0.0534 0.1114 0.3204
Loa Loa (eye worm) hypothetical protein 0.0433 0.0854 0.0854
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0171 0.0175 0.0175
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0336 0.0602 0.0684
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0134 0.0079 0.0172
Brugia malayi Immunoglobulin I-set domain containing protein 0.0139 0.0093 0.0093
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0155 0.0133 0.0676
Echinococcus granulosus casein kinase i 0.0271 0.0434 0.0951
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0227 0.0319 0.0319
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0355 0.0652 0.0741
Loa Loa (eye worm) hypothetical protein 0.0213 0.0284 0.0284
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0213 0.0284 0.0816
Echinococcus granulosus TGF beta receptor type 1 0.037 0.0691 0.1512
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0139 0.0093 0.0093
Echinococcus multilocularis raf serine:threonine protein kinase 0.0169 0.0171 0.0194
Echinococcus multilocularis casein kinase i 0.0271 0.0434 0.0494
Entamoeba histolytica casein kinase 1, putative 0.0271 0.0434 0.2588
Trichomonas vaginalis CMGC family protein kinase 0.0298 0.0505 0.3191
Echinococcus multilocularis twitchin 0.0155 0.0135 0.0154
Trypanosoma cruzi cdc2-related kinase 3 0.0298 0.0505 0.2068
Schistosoma mansoni protein kinase 0.0134 0.0079 0.0226
Echinococcus granulosus casein kinase I delta 0.0271 0.0434 0.0951
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0646 0.413
Echinococcus multilocularis serine:threonine protein kinase 38 0.0159 0.0145 0.0165
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0322 0.0566 0.2331
Entamoeba histolytica hypothetical protein 0.0723 0.1602 1
Echinococcus granulosus protein kinase c epsilon type 0.0215 0.029 0.0634
Schistosoma mansoni serine/threonine protein kinase 0.0576 0.1224 0.3522
Trichomonas vaginalis AGC family protein kinase 0.0175 0.0187 0.1067
Onchocerca volvulus 0.0684 0.1501 0.1501
Echinococcus multilocularis casein kinase I delta 0.0271 0.0434 0.0494
Brugia malayi Cam kinase protein 1 0.0227 0.0319 0.0319
Echinococcus multilocularis mitogen activated protein kinase 11 0.1008 0.234 0.2658
Schistosoma mansoni serine/threonine protein kinase 0.0723 0.1602 0.4611
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0355 0.0652 0.1427
Entamoeba histolytica casein kinase, putative 0.0271 0.0434 0.2588
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0154 0.0132 0.0381
Brugia malayi Immunoglobulin I-set domain containing protein 0.0154 0.0132 0.0132
Echinococcus multilocularis 0.0509 0.1049 0.1192
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0209 0.0274 0.0274
Trichomonas vaginalis CAMK family protein kinase 0.0163 0.0154 0.0848
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0204 0.026 0.1008
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0569 0.1205 0.1205
Schistosoma mansoni tyrosine kinase 0.0114 0.0027 0.0077
Brugia malayi Immunoglobulin I-set domain containing protein 0.0171 0.0175 0.0175
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0271 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.027 0.043 0.043
Giardia lamblia Kinase, NEK 0.0503 0.1033 0.6713
Loa Loa (eye worm) TK/FER protein kinase 0.0114 0.0027 0.0027
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0576 0.1224 0.5176
Echinococcus multilocularis natriuretic peptide receptor 1 0.0114 0.0027 0.003
Loa Loa (eye worm) hypothetical protein 0.0444 0.0882 0.0882
Loa Loa (eye worm) TK/FER protein kinase 0.0201 0.0252 0.0252
Trichomonas vaginalis STE family protein kinase 0.0134 0.0079 0.0347
Schistosoma mansoni hypothetical protein 0.0149 0.0119 0.0343
Trichomonas vaginalis AGC family protein kinase 0.0175 0.0187 0.1067
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0298 0.0505 0.0505
Entamoeba histolytica protein kinase, putative 0.0114 0.0027 0.000000024785
Onchocerca volvulus 0.0201 0.0252 0.0252
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0383 0.0724 0.1585
Trichomonas vaginalis TKL family protein kinase 0.0114 0.0027 0.000000026049
Echinococcus granulosus MAM 0.0149 0.0119 0.0261
Echinococcus granulosus tyrosine kinase 0.0114 0.0027 0.0058
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0695 0.153 0.1738
Echinococcus granulosus protein kinase 0.0321 0.0563 0.1233
Echinococcus multilocularis plexin a4 0.0142 0.01 0.0113
Echinococcus multilocularis death associated protein kinase 1 0.3506 0.8802 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0143 0.0103 0.0296
Entamoeba histolytica protein kinase, putative 0.015 0.012 0.0592
Brugia malayi Immunoglobulin I-set domain containing protein 0.0154 0.0132 0.0132
Brugia malayi Protein kinase domain containing protein 0.0159 0.0145 0.0145
Trypanosoma brucei cdc2-related kinase 1 0.0298 0.0505 0.2068
Echinococcus granulosus peroxidasin 0.0141 0.0097 0.0213
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0841 0.1909 0.1909
Onchocerca volvulus 0.0258 0.0401 0.0401
Schistosoma mansoni ephrin receptor 0.0129 0.0066 0.019
Giardia lamblia Kinase, CMGC GSK 0.0471 0.0952 0.6169
Entamoeba histolytica hypothetical protein 0.0115 0.0031 0.0026
Echinococcus multilocularis hemicentin 1 0.0139 0.0093 0.0106
Giardia lamblia Kinase, CMGC CLK 0.0576 0.1224 0.7986
Brugia malayi Tyrosine-protein kinase abl-1 0.054 0.113 0.113
Entamoeba histolytica protein kinase, putative 0.0723 0.1602 1
Loa Loa (eye worm) gastrulation defective protein 1 0.0844 0.1915 0.1915
Schistosoma mansoni protein kinase 0.1 0.232 0.6676
Echinococcus multilocularis protein kinase 0.0114 0.0027 0.003
Schistosoma mansoni protein kinase 0.0749 0.1669 0.4803
Entamoeba histolytica protein kinase, putative 0.0471 0.0952 0.587
Brugia malayi bone morphogenetic protein type 1 receptor 0.0416 0.081 0.081
Schistosoma mansoni protein kinase 0.0114 0.0027 0.0077
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.1008 0.234 1
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0305 0.0522 0.1502
Schistosoma mansoni serine/threonine protein kinase 0.0298 0.0505 0.1453
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1869 0.4568 1
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0255 0.0391 0.0857
Loa Loa (eye worm) hypothetical protein 0.0114 0.0027 0.0027
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0181 0.0201 0.0755
Brugia malayi Protein kinase domain containing protein 0.0749 0.1669 0.1669
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0159 0.0145 0.0145
Onchocerca volvulus 0.0112 0.0021 0.0021
Schistosoma mansoni tyrosine kinase 0.0248 0.0375 0.1079
Onchocerca volvulus 0.0616 0.1327 0.1327
Loa Loa (eye worm) hypothetical protein 0.0258 0.0401 0.0401
Echinococcus granulosus raf serine:threonine protein kinase 0.0169 0.0171 0.0374
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0201 0.0252 0.0552
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0159 0.0145 0.0145
Echinococcus multilocularis epidermal growth factor receptor 0.0362 0.0668 0.0759
Brugia malayi hypothetical protein 0.0182 0.0205 0.0205
Brugia malayi Protein kinase domain containing protein 0.0775 0.1738 0.1738
Brugia malayi serine/threonine-protein kinase 6 0.0425 0.0833 0.0833
Echinococcus multilocularis cyclin dependent kinase 7 0.0392 0.0747 0.0849
Echinococcus granulosus contactin 0.0154 0.0132 0.029
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0753 0.168 0.1908
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0555 0.1169 0.1169
Echinococcus granulosus tyrosine protein kinase csk 0.0114 0.0027 0.0058
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0222 0.0307 0.0307
Leishmania major protein kinase, putative 0.0181 0.0201 0.0755
Brugia malayi C1-like domain containing protein 0.0381 0.072 0.072
Giardia lamblia Kinase, CAMK CAMKL 0.018 0.0198 0.1141
Plasmodium falciparum NIMA related kinase 1 0.0503 0.1033 0.8406
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0298 0.0505 0.2068
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0114 0.0027 0.0027
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.0952 0.587
Schistosoma mansoni tyrosine kinase 0.0114 0.0027 0.0077
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0695 0.153 0.3349
Echinococcus granulosus receptor type guanylyl cyclase 0.0114 0.0027 0.0058
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0298 0.0505 0.0505
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0298 0.0505 0.0505
Loa Loa (eye worm) RGC/RGC protein kinase 0.0114 0.0027 0.0027
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0114 0.0027 0.0027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0646 0.413
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.029 0.0833
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0215 0.029 0.0329
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0114 0.0027 0.0027
Entamoeba histolytica protein kinase, putative 0.0155 0.0133 0.0676
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0027 0.0077
Brugia malayi Protein kinase domain containing protein 0.0201 0.0252 0.0252
Echinococcus multilocularis tyrosine protein kinase 0.0114 0.0027 0.003
Echinococcus multilocularis tyrosine protein kinase shark 0.0201 0.0252 0.0287
Schistosoma mansoni tyrosine kinase 0.0532 0.1108 0.3188
Loa Loa (eye worm) hypothetical protein 0.0433 0.0854 0.0854
Schistosoma mansoni tyrosine kinase 0.0253 0.0387 0.1112
Schistosoma mansoni serine/threonine protein kinase 0.1285 0.3057 0.8795
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0425 0.0833 0.5116
Echinococcus multilocularis cyclin dependent kinase 19 0.0911 0.209 0.2374
Brugia malayi protein kinase C II. 0.0215 0.029 0.029
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0227 0.0319 0.2441
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0609 0.1309 0.1309
Echinococcus multilocularis tyrosine protein kinase csk 0.0114 0.0027 0.003
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.042 0.0818 0.093
Trichomonas vaginalis TKL family protein kinase 0.0114 0.0027 0.000000026049
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0114 0.0027 0.0077
Echinococcus granulosus protein kinase 0.0114 0.0027 0.0058
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0646 0.393
Echinococcus multilocularis casein kinase I alpha 0.0271 0.0434 0.0494
Trichomonas vaginalis CAMK family protein kinase 0.0163 0.0154 0.0848
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0471 0.0952 0.3999
Brugia malayi Fibronectin type III domain containing protein 0.032 0.0561 0.0561
Brugia malayi Protein kinase domain containing protein 0.0416 0.081 0.081
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0514 0.1063 0.1063
Trichomonas vaginalis TKL family protein kinase 0.0114 0.0027 0.000000026049
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0114 0.0027 0.0027
Echinococcus multilocularis slit 2 protein 0.0121 0.0046 0.0052
Onchocerca volvulus 0.0433 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.07 0.1544 0.1544
Schistosoma mansoni tyrosine kinase 0.0114 0.0027 0.0077
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0468 0.0944 0.0944
Echinococcus granulosus growth factor receptor bound protein 2 0.0158 0.0142 0.0312
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0322 0.0566 0.2331
Brugia malayi Variant SH3 domain containing protein 0.0143 0.0103 0.0103
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0139 0.0093 0.0093
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0514 0.1063 0.2327
Brugia malayi Stress-activated protein kinase jnk-1 0.1043 0.2431 0.2431
Schistosoma mansoni protein kinase 0.0114 0.0027 0.0077
Schistosoma mansoni protein kinase C mu 0.0381 0.072 0.207
Echinococcus granulosus integrin linked protein kinase 0.0114 0.0027 0.0058
Trypanosoma cruzi casein kinase, putative 0.0271 0.0434 0.1763
Loa Loa (eye worm) TK protein kinase 0.0114 0.0027 0.0027
Entamoeba histolytica protein kinase domain containing protein 0.0425 0.0833 0.5116
Loa Loa (eye worm) hypothetical protein 0.0231 0.033 0.033
Echinococcus granulosus tyrosine protein kinase pr2 0.0114 0.0027 0.0058
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Loa Loa (eye worm) TK protein kinase 0.0114 0.0027 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0175 0.0187 0.1067
Brugia malayi hypothetical protein 0.0201 0.0252 0.0252
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0968 0.2236 0.2541
Brugia malayi intracellular kinase 0.0471 0.0952 0.0952
Loa Loa (eye worm) TK/FER protein kinase 0.0114 0.0027 0.0027
Schistosoma mansoni ephrin receptor 0.0114 0.0027 0.0077
Brugia malayi Protein kinase domain containing protein 0.0723 0.1602 0.1602
Loa Loa (eye worm) TK/EPH protein kinase 0.0114 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0112 0.0021 0.0021
Giardia lamblia Kinase, CMGC GSK 0.0471 0.0952 0.6169
Echinococcus granulosus tyrosine protein kinase Fyn 0.042 0.0818 0.1791
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0163 0.0154 0.0848
Echinococcus granulosus retinal guanylyl cyclase 2 0.0114 0.0027 0.0058
Loa Loa (eye worm) TK protein kinase 0.0114 0.0027 0.0027
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0201 0.0254 0.0556
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0114 0.0027 0.0027
Echinococcus multilocularis Immunoglobulin 0.0305 0.0522 0.0593
Brugia malayi protein kinase C3,putative 0.0123 0.0052 0.0052
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.037 0.0691 0.0785
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0471 0.0952 0.2083
Echinococcus granulosus cyclin dependent kinase 19 0.0911 0.209 0.4574
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0753 0.168 0.168
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0749 0.1669 0.3654
Schistosoma mansoni serine/threonine protein kinase 0.0753 0.168 0.4833
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0213 0.0284 0.0322
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0134 0.0079 0.0172
Entamoeba histolytica p21-activated kinase 0.015 0.012 0.0592
Schistosoma mansoni protein kinase 0.0321 0.0563 0.162
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0139 0.0093 0.0093
Schistosoma mansoni cell adhesion molecule 0.0139 0.0093 0.0268
Loa Loa (eye worm) AGC/AKT protein kinase 0.0175 0.0187 0.0187
Loa Loa (eye worm) RGC/RGC protein kinase 0.0114 0.0027 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0514 0.1063 0.3058
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0143 0.0103 0.0225
Brugia malayi hypothetical protein 0.0149 0.0119 0.0119
Schistosoma mansoni protein kinase 0.0134 0.0079 0.0226
Loa Loa (eye worm) hypothetical protein 0.0305 0.0522 0.0522
Leishmania major protein kinase, putative 0.0576 0.1224 0.5176
Loa Loa (eye worm) hypothetical protein 0.0322 0.0566 0.0566
Trichomonas vaginalis CK1 family protein kinase 0.0271 0.0434 0.272
Echinococcus multilocularis protein kinase 0.0114 0.0027 0.003
Loa Loa (eye worm) hypothetical protein 0.0114 0.0027 0.0027
Schistosoma mansoni tyrosine kinase 0.0265 0.0419 0.1205
Brugia malayi Protein kinase domain containing protein 0.0315 0.0548 0.0548
Echinococcus multilocularis 0.0321 0.0563 0.064
Schistosoma mansoni tyrosine kinase 0.0383 0.0724 0.2083
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0139 0.0093 0.0268
Schistosoma mansoni titin 0.0171 0.0175 0.0502
Echinococcus multilocularis tyrosine protein kinase csk 0.0114 0.0027 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0163 0.0154 0.0848
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0315 0.0548 0.0548
Toxoplasma gondii AGC kinase 0.0322 0.0566 0.4504
Schistosoma mansoni roundabout 0.0139 0.0093 0.0268
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0749 0.1669 0.1669
Schistosoma mansoni vesicular amine transporter 0.0305 0.0522 0.1502
Entamoeba histolytica hypothetical protein 0.0115 0.0031 0.0026
Echinococcus granulosus protein kinase shaggy 0.0471 0.0952 0.2083
Brugia malayi Protein kinase domain containing protein 0.0159 0.0145 0.0145
Trichomonas vaginalis CAMK family protein kinase 0.0227 0.0319 0.195
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Brugia malayi Variant SH3 domain containing protein 0.0152 0.0125 0.0125
Onchocerca volvulus 0.0114 0.0027 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0322 0.0566 0.3597
Schistosoma mansoni hypothetical protein 0.0205 0.0262 0.0755
Trichomonas vaginalis AGC family protein kinase 0.0175 0.0187 0.1067
Trichomonas vaginalis CAMK family protein kinase 0.0163 0.0154 0.0848
Onchocerca volvulus 0.0114 0.0027 0.0027
Schistosoma mansoni tyrosine kinase 0.0114 0.0027 0.0077
Schistosoma mansoni tyrosine kinase 0.0114 0.0027 0.0077
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0145 0.0792
Loa Loa (eye worm) TK/DDR protein kinase 0.0114 0.0027 0.0027
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0154 0.0132 0.015
Schistosoma mansoni serine/threonine protein kinase 0.0684 0.1501 0.4319
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1635 0.3961 0.3961
Onchocerca volvulus 0.0114 0.0027 0.0027
Loa Loa (eye worm) AGC/PKN protein kinase 0.0159 0.0145 0.0145
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0753 0.168 0.168
Loa Loa (eye worm) AGC/PKA protein kinase 0.0322 0.0566 0.0566
Echinococcus multilocularis tyrosine protein kinase csk 0.0114 0.0027 0.003
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0114 0.0027 0.0077
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0532 0.1108 0.1259
Loa Loa (eye worm) RGC/RGC protein kinase 0.0114 0.0027 0.0027
Trypanosoma brucei protein kinase, putative 0.0471 0.0952 0.3999
Giardia lamblia Kinase, AGC PKA 0.0322 0.0566 0.3597
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0693 0.1526 0.6482
Loa Loa (eye worm) hypothetical protein 0.0305 0.0522 0.0522
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0305 0.0522 0.0593
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0775 0.1738 0.3804
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0471 0.0952 0.3999
Echinococcus multilocularis mitogen activated protein kinase 14 0.1008 0.234 0.2658
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0609 0.1309 0.1309
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0356 0.0654 0.1433
Echinococcus multilocularis tyrosine protein kinase HCK 0.0268 0.0426 0.0484
Echinococcus multilocularis N chimaerin 0.0143 0.0103 0.0117
Entamoeba histolytica ankyrin repeat protein 0.0114 0.0027 0.000000024785
Echinococcus granulosus tyrosine protein kinase Lyn 0.0487 0.0993 0.2173
Schistosoma mansoni serine/threonine protein kinase 0.0244 0.0364 0.1048
Loa Loa (eye worm) hypothetical protein 0.0114 0.0027 0.0027
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0114 0.0027 0.0027
Schistosoma mansoni serine/threonine RGC 0.0114 0.0027 0.0077
Schistosoma mansoni tyrosine kinase 0.0248 0.0375 0.1079
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0425 0.0833 0.5116
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0315 0.0549 0.1201
Schistosoma mansoni protein kinase 0.0695 0.153 0.4402
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.0646 0.5
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0114 0.0027 0.0027
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0383 0.0383
Entamoeba histolytica protein kinase, putative 0.0425 0.0833 0.5116
Loa Loa (eye worm) TK/FER protein kinase 0.0201 0.0252 0.0252
Giardia lamblia Kinase, CK1 Casein kinase 0.0271 0.0434 0.272
Trypanosoma cruzi casein kinase, putative 0.0271 0.0434 0.1763
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0201 0.0252 0.1432
Schistosoma mansoni serine/threonine kinase 0.0159 0.0145 0.0418
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0968 0.2236 0.4896
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0143 0.0103 0.0117
Onchocerca volvulus 0.0201 0.0252 0.0252
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0154 0.0132 0.015
Echinococcus multilocularis cyclin dependent kinase 1 0.0298 0.0505 0.0574
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0315 0.0548 0.0622
Onchocerca volvulus 0.0201 0.0252 0.0252
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0143 0.0103 0.0296
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0723 0.1602 0.6813
Loa Loa (eye worm) protein kinase domain-containing protein 0.0114 0.0027 0.0027
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0139 0.0093 0.0106
Schistosoma mansoni serine/threonine protein kinase 0.0775 0.1738 0.5001
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0163 0.0154 0.0154
Brugia malayi Sex muscle abnormal protein 5 0.0152 0.0125 0.0125
Schistosoma mansoni serine/threonine protein kinase 0.1043 0.2431 0.6994
Echinococcus granulosus slit 2 protein 0.0121 0.0046 0.0101
Brugia malayi serine/threonine kinase 12 0.0425 0.0833 0.0833
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0114 0.0027 0.0058
Loa Loa (eye worm) hypothetical protein 0.0314 0.0545 0.0545
Brugia malayi casein kinase I 0.0271 0.0434 0.0434
Entamoeba histolytica protein kinase, putative 0.0114 0.0027 0.000000024785
Echinococcus granulosus tyrosine protein kinase ABL1 0.1075 0.2515 0.5505
Trichomonas vaginalis CAMK family protein kinase 0.0163 0.0154 0.0848
Brugia malayi Immunoglobulin I-set domain containing protein 0.0139 0.0093 0.0093
Echinococcus granulosus neuroglian 0.0154 0.0132 0.029
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0114 0.0027 0.0077
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0576 0.1224 0.1224
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0143 0.0103 0.0103
Brugia malayi Raf kinase 0.0114 0.0027 0.0027
Echinococcus granulosus tyrosine protein kinase HCK 0.0268 0.0426 0.0933
Trypanosoma brucei casein kinase I, isoform 2 0.0271 0.0434 0.1763
Plasmodium falciparum calcium-dependent protein kinase 1 0.0227 0.0319 0.2441
Loa Loa (eye worm) hypothetical protein 0.0154 0.0132 0.0132
Trichomonas vaginalis CMGC family protein kinase 0.0576 0.1224 0.7986
Plasmodium falciparum casein kinase 1 0.0271 0.0434 0.3406
Echinococcus granulosus tyrosine protein kinase Fyn 0.042 0.0818 0.1791
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.029 0.0833
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1008 0.234 1
Plasmodium falciparum serine/threonine protein kinase, putative 0.0425 0.0833 0.6733
Echinococcus granulosus cyclin dependent kinase 0.0298 0.0505 0.1106
Echinococcus granulosus roundabout 2 0.0154 0.0132 0.029
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Trichomonas vaginalis CMGC family protein kinase 0.0298 0.0505 0.3191
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.1285 0.3057 0.3057
Loa Loa (eye worm) TK/FAK protein kinase 0.1463 0.3517 0.3517
Schistosoma mansoni nephrin 0.0154 0.0132 0.0381
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0471 0.0952 0.0952
Echinococcus granulosus insulin growth factor 1 receptor beta 0.068 0.1491 0.3264
Schistosoma mansoni tyrosine kinase 0.0362 0.0668 0.1923
Trichomonas vaginalis AGC family protein kinase 0.0425 0.0833 0.5377
Schistosoma mansoni serine/threonine protein kinase 0.0609 0.1309 0.3767
Echinococcus granulosus natriuretic peptide receptor 1 0.0114 0.0027 0.0058
Schistosoma mansoni tyrosine kinase 0.0362 0.0668 0.1923
Brugia malayi Immunoglobulin I-set domain containing protein 0.0139 0.0093 0.0093
Echinococcus multilocularis casein kinase I alpha 0.0271 0.0434 0.0494
Toxoplasma gondii histone kinase SNF1, putative 0.0163 0.0154 0.1062
Onchocerca volvulus 0.0171 0.0175 0.0175
Entamoeba histolytica protein kinase, putative 0.0425 0.0833 0.5116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0646 0.413
Brugia malayi Tyrosine-protein kinase PR2 0.0114 0.0027 0.0027
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0215 0.029 0.029
Echinococcus multilocularis NCK adaptor protein 0.0158 0.0142 0.0162
Echinococcus multilocularis ephrin type A receptor 4 A 0.0114 0.0027 0.003
Loa Loa (eye worm) TK protein kinase 0.0114 0.0027 0.0027
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.042 0.0818 0.1791
Onchocerca volvulus 0.0114 0.0027 0.0027
Brugia malayi Immunoglobulin I-set domain containing protein 0.0139 0.0093 0.0093
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.042 0.0818 0.093
Brugia malayi Serine/threonine-protein kinase SULU 0.1285 0.3057 0.3057
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0532 0.1108 0.2425
Echinococcus multilocularis serine threonine protein kinase 0.0159 0.0145 0.0165
Echinococcus multilocularis tyrosine protein kinase Fgr 0.042 0.0818 0.093
Schistosoma mansoni tyrosine kinase 0.0114 0.0027 0.0077
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0693 0.1526 0.6482
Echinococcus granulosus cyclin dependent kinase 1 0.0298 0.0505 0.1106
Trichomonas vaginalis CMGC family protein kinase 0.0471 0.0952 0.6169
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0693 0.1526 0.1526
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Brugia malayi Immunoglobulin I-set domain containing protein 0.0139 0.0093 0.0093
Trichomonas vaginalis CAMK family protein kinase 0.0163 0.0154 0.0848
Echinococcus granulosus aurora kinase A 0.0425 0.0833 0.1823
Loa Loa (eye worm) hypothetical protein 0.032 0.0561 0.0561
Onchocerca volvulus 0.0286 0.0473 0.0473
Schistosoma mansoni serine/threonine protein kinase 0.0322 0.0566 0.1628
Echinococcus multilocularis dual specificity testis specific protein kinase 0.1 0.232 0.2636
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Schistosoma mansoni protein kinase 0.0134 0.0079 0.0226
Entamoeba histolytica protein kinase domain containing protein 0.0164 0.0157 0.083
Trypanosoma cruzi aurora B kinase, putative 0.0425 0.0833 0.3485
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0322 0.0566 0.0566
Trichomonas vaginalis AGC family protein kinase 0.0425 0.0833 0.5377
Loa Loa (eye worm) TK/FER protein kinase 0.0201 0.0252 0.0252
Echinococcus granulosus ephrin type A receptor 4 A 0.0114 0.0027 0.0058
Giardia lamblia Protein 21.1 0.0114 0.0027 0.000000026049
Echinococcus multilocularis growth factor receptor bound protein 2 0.0152 0.0125 0.0142
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0322 0.0566 0.0643
Trypanosoma brucei protein kinase, putative 0.0181 0.0201 0.0755
Loa Loa (eye worm) TK/FER protein kinase 0.0201 0.0252 0.0252
Loa Loa (eye worm) TK/EGFR protein kinase 0.0362 0.0668 0.0668
Loa Loa (eye worm) hypothetical protein 0.2267 0.5598 0.5598
Echinococcus granulosus protein kinase C gamma type 0.0159 0.0145 0.0318
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0576 0.1224 0.5176
Echinococcus granulosus tyrosine kinase 0.0355 0.0652 0.1427
Schistosoma mansoni adapter molecule crk 0.0152 0.0125 0.036
Loa Loa (eye worm) TK protein kinase 0.062 0.1336 0.1336
Loa Loa (eye worm) hypothetical protein 0.0433 0.0854 0.0854
Brugia malayi Protein kinase domain containing protein 0.1984 0.4865 0.4865
Echinococcus multilocularis dual specificity mitogen activated protein 0.0693 0.1526 0.1734
Echinococcus granulosus N chimaerin 0.0143 0.0103 0.0225
Schistosoma mansoni serine/threonine protein kinase 0.0392 0.0747 0.215
Plasmodium falciparum protein kinase, putative 0.0181 0.0201 0.1458
Loa Loa (eye worm) TK/FER protein kinase 0.0201 0.0252 0.0252
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0576 0.1224 0.5176
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0322 0.0566 0.1239
Brugia malayi Protein kinase domain containing protein 0.0814 0.1838 0.1838
Loa Loa (eye worm) hypothetical protein 0.0201 0.0252 0.0252
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0503 0.1033 0.8406
Loa Loa (eye worm) TK protein kinase 0.0355 0.0652 0.0652
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0555 0.1169 0.1328
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0532 0.1108 0.1259
Trichomonas vaginalis CAMK family protein kinase 0.0163 0.0154 0.0848
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0227 0.0319 0.2441
Echinococcus multilocularis serine:threonine protein kinase N2 0.0159 0.0145 0.0165
Toxoplasma gondii AGC kinase 0.0159 0.0145 0.0992
Trichomonas vaginalis TKL family protein kinase 0.0116 0.0032 0.0035
Brugia malayi Immunoglobulin I-set domain containing protein 0.0209 0.0274 0.0274
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0381 0.072 0.072
Echinococcus granulosus tyrosine protein kinase Blk 0.0355 0.0652 0.1427
Entamoeba histolytica hypothetical protein 0.0115 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.0121 0.0046 0.0046
Trichomonas vaginalis AGC family protein kinase 0.0175 0.0187 0.1067
Loa Loa (eye worm) hypothetical protein 0.0466 0.0939 0.0939
Schistosoma mansoni tyrosine kinase 0.042 0.0818 0.2354
Brugia malayi Temporarily assigned gene name protein 59 0.0213 0.0284 0.0284
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0322 0.0566 0.2331
Echinococcus multilocularis receptor type guanylyl cyclase 0.0114 0.0027 0.003
Schistosoma mansoni tyrosine kinase 0.0114 0.0027 0.0077
Echinococcus granulosus retinal guanylyl cyclase 2 0.0114 0.0027 0.0058
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0179 0.5
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0031 0.0068
Brugia malayi SH2 domain containing protein 0.0201 0.0252 0.0252
Echinococcus multilocularis tyrosine protein kinase csk 0.0114 0.0027 0.003
Giardia lamblia Kinase, CMGC CDK 0.0298 0.0505 0.3191
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.0398 0.1603
Echinococcus granulosus casein kinase I alpha 0.0271 0.0434 0.0951
Loa Loa (eye worm) hypothetical protein 0.0149 0.0119 0.0119
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.068 0.1491 0.1694
Schistosoma mansoni tyrosine kinase 0.0114 0.0027 0.0077
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0227 0.0319 0.0319
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0471 0.0952 0.1081
Loa Loa (eye worm) hypothetical protein 0.0258 0.0401 0.0401
Loa Loa (eye worm) hypothetical protein 0.0114 0.0027 0.0027
Giardia lamblia Kinase, NEK 0.0503 0.1033 0.6713
Brugia malayi P38 map kinase family protein 2 0.1008 0.234 0.234
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0152 0.0125 0.0125
Schistosoma mansoni protein kinase 0.0695 0.153 0.4402
Loa Loa (eye worm) TK/FER protein kinase 0.0201 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0163 0.0154 0.0154
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0213 0.0284 0.0816
Echinococcus multilocularis titin 0.0171 0.0175 0.0198
Onchocerca volvulus Tyrosine kinase homolog 0.1366 0.3267 0.3267
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0114 0.0027 0.0077
Echinococcus granulosus insulin receptor 0.0664 0.1452 0.3177
Trichomonas vaginalis AGC family protein kinase 0.0175 0.0187 0.1067
Brugia malayi C-terminal src kinase protein 1 0.0114 0.0027 0.0027
Brugia malayi Peroxidasin 0.0141 0.0097 0.0097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0646 0.413
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0114 0.0027 0.003
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0271 0.0434 0.0434
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0106 0.0106
Brugia malayi SH2 domain containing protein 0.0201 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0114 0.0027 0.0027
Onchocerca volvulus 0.3969 1 1
Schistosoma mansoni nephrin 0.0408 0.0789 0.227
Loa Loa (eye worm) hypothetical protein 0.0258 0.0401 0.0401
Toxoplasma gondii aurora kinase 0.0425 0.0833 0.6733
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0227 0.0319 0.0319
Brugia malayi probable protein kinase 0.0534 0.1114 0.1114
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0179 0.5
Trypanosoma cruzi cdc2-related kinase 1 0.0298 0.0505 0.2068
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0271 0.0434 0.0434
Entamoeba histolytica protein kinase, putative 0.0175 0.0187 0.1015
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0576 0.1224 0.5176
Entamoeba histolytica protein kinase, putative 0.0134 0.0079 0.033
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0114 0.0027 0.003
Loa Loa (eye worm) hypothetical protein 0.0139 0.0093 0.0093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0646 0.413
Brugia malayi hypothetical protein 0.0114 0.0027 0.0027
Echinococcus multilocularis epidermal growth factor receptor 0.0362 0.0668 0.0759
Echinococcus granulosus serine:threonine protein kinase TAO1 0.1285 0.3057 0.6691
Echinococcus multilocularis protein kinase shaggy 0.0471 0.0952 0.1081
Brugia malayi Plexin repeat family protein 0.0112 0.0021 0.0021
Echinococcus granulosus tyrosine protein kinase Src42A 0.042 0.0818 0.1791
Brugia malayi jmjC domain containing protein 0.0115 0.0031 0.0031
Echinococcus multilocularis activin receptor type 0.1727 0.42 0.4772
Brugia malayi Prion-like- 0.0139 0.0093 0.0093
Brugia malayi p70 ribosomal S6 kinase beta 0.0159 0.0145 0.0145
Loa Loa (eye worm) TK/FER protein kinase 0.0201 0.0252 0.0252
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0114 0.0027 0.0027
Plasmodium falciparum calcium-dependent protein kinase 2 0.0227 0.0319 0.2441
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0322 0.0566 0.2331
Loa Loa (eye worm) hypothetical protein 0.0213 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0814 0.1838 0.1838
Schistosoma mansoni serine/threonine protein kinase 0.0169 0.0171 0.0492
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0213 0.0284 0.111
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0322 0.0566 0.0643
Trichomonas vaginalis CAMK family protein kinase 0.0163 0.0154 0.0848
Leishmania major protein kinase, putative 0.0227 0.0319 0.1264
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0322 0.0566 0.1239
Loa Loa (eye worm) hypothetical protein 0.0593 0.1266 0.1266
Giardia lamblia Kinase, STE STE20 0.0134 0.0079 0.0347
Plasmodium falciparum calcium-dependent protein kinase 4 0.0227 0.0319 0.2441
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0514 0.1063 0.1208
Echinococcus granulosus NDR protein kinase 0.0159 0.0145 0.0318
Echinococcus granulosus epidermal growth factor receptor 0.0362 0.0668 0.1463
Schistosoma mansoni serine/threonine protein kinase 0.0536 0.1119 0.3219
Trichomonas vaginalis CAMK family protein kinase 0.0163 0.0154 0.0848
Loa Loa (eye worm) hypothetical protein 0.0444 0.0882 0.0882
Leishmania major casein kinase, putative 0.0271 0.0434 0.1763
Schistosoma mansoni tyrosine kinase 0.0362 0.0668 0.1923
Schistosoma mansoni cell adhesion molecule 0.0154 0.0132 0.0381
Loa Loa (eye worm) SRC-1 0.042 0.0818 0.0818
Schistosoma mansoni protein kinase 0.1 0.232 0.6676
Giardia lamblia Kinase, NEK 0.0114 0.0027 0.000000026049
Echinococcus granulosus neuroglian 0.0393 0.075 0.1641
Echinococcus granulosus kinase suppressor of Ras 1 0.0114 0.0027 0.0058
Entamoeba histolytica cell division protein kinase 2, putative 0.0315 0.0549 0.3314
Giardia lamblia Aurora kinase 0.0425 0.0833 0.5377
Echinococcus granulosus casein kinase I alpha 0.0271 0.0434 0.0951
Echinococcus multilocularis lachesin 0.0139 0.0093 0.0106
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0181 0.0201 0.0755
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0163 0.0154 0.055
Echinococcus granulosus dual specificity mitogen activated protein 0.0693 0.1526 0.334
Schistosoma mansoni tyrosine kinase 0.0114 0.0027 0.0077
Brugia malayi Variant SH3 domain containing protein 0.0152 0.0125 0.0125
Schistosoma mansoni atypical protein kinase C 0.0215 0.029 0.0833
Loa Loa (eye worm) TK/FER protein kinase 0.0114 0.0027 0.0027
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0471 0.0952 0.7725
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0154 0.0132 0.0132
Trichomonas vaginalis CAMK family protein kinase 0.0163 0.0154 0.0848
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0305 0.0522 0.1502
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0425 0.0833 0.5116
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0114 0.0027 0.003
Entamoeba histolytica protein kinase, putative 0.0159 0.0145 0.0754
Echinococcus granulosus titin 0.0171 0.0175 0.0382
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0163 0.0154 0.0175
Loa Loa (eye worm) serine/threonine protein kinase 0.0114 0.0027 0.0027
Onchocerca volvulus 0.0204 0.026 0.026
Echinococcus multilocularis c Jun NH2 terminal kinase 0.1043 0.2431 0.2761
Echinococcus multilocularis neuroglian 0.0154 0.0132 0.015
Loa Loa (eye worm) TK/FER protein kinase 0.0201 0.0252 0.0252
Echinococcus multilocularis tyrosine protein kinase Srms 0.0355 0.0652 0.0741
Onchocerca volvulus 0.0114 0.0027 0.0027
Trypanosoma cruzi cdc2-related kinase 3 0.0298 0.0505 0.2068
Onchocerca volvulus 0.0201 0.0252 0.0252
Onchocerca volvulus 0.0114 0.0027 0.0027
Echinococcus granulosus Protein kinase C brain isozyme 0.0215 0.029 0.0634
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0646 0.413
Brugia malayi EGF-like domain containing protein 0.0121 0.0046 0.0046
Entamoeba histolytica PH domain containing protein kinase, putative 0.0338 0.0607 0.3684
Plasmodium falciparum protein kinase 5 0.0298 0.0505 0.3996
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0569 0.1205 0.1205
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Giardia lamblia Kinase, NEK 0.0503 0.1033 0.6713
Schistosoma mansoni growth factor receptor-bound protein 0.0152 0.0125 0.036
Brugia malayi Protein kinase domain containing protein 0.0201 0.0252 0.0252
Trichomonas vaginalis AGC family protein kinase 0.0175 0.0187 0.1067
Echinococcus multilocularis TGF beta receptor type 1 0.037 0.0691 0.0785
Loa Loa (eye worm) TK/RYK protein kinase 0.0114 0.0027 0.0027
Trypanosoma brucei SNF1-related protein kinases, putative 0.0163 0.0154 0.055
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0159 0.0145 0.0318
Plasmodium falciparum serine/threonine protein kinase KIN 0.0163 0.0154 0.1062
Echinococcus granulosus serine:threonine kinase SAD 1 0.0163 0.0154 0.0337
Loa Loa (eye worm) TK protein kinase 0.0114 0.0027 0.0027
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0114 0.0027 0.003
Loa Loa (eye worm) hypothetical protein 0.0227 0.0319 0.0319
Echinococcus granulosus Vam6:Vps39 protein 0.0213 0.0284 0.0621
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0425 0.0833 0.0946
Brugia malayi protein-tyrosine kinase 0.0355 0.0652 0.0652
Schistosoma mansoni serine/threonine protein kinase 0.0425 0.0833 0.2396
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0154 0.0132 0.029
Brugia malayi ephrin receptor 1 precursor 0.0114 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.032 0.0561 0.0561
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0213 0.0284 0.0621
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0336 0.0602 0.1318
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.042 0.0818 0.093
Leishmania major protein kinase A catalytic subunit 0.0322 0.0566 0.2331
Loa Loa (eye worm) hypothetical protein 0.0213 0.0284 0.0284
Brugia malayi Protein kinase domain containing protein 0.0201 0.0252 0.0252
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0381 0.072 0.072
Onchocerca volvulus 0.0271 0.0434 0.0434
Onchocerca volvulus 0.0114 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0114 0.0027 0.0027
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.028 0.0458 0.052
Loa Loa (eye worm) hypothetical protein 0.0182 0.0205 0.0205
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0114 0.0027 0.0058
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0265 0.0419 0.1205
Echinococcus granulosus tyrosine protein kinase Src64B 0.042 0.0818 0.1791
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0159 0.0145 0.0165
Onchocerca volvulus 0.033 0.0586 0.0586
Schistosoma mansoni protein kinase 0.0693 0.1526 0.4391
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0163 0.0154 0.055
Echinococcus multilocularis cyclin dependent kinase 0.0298 0.0505 0.0574
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0123 0.0052 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0392 0.0747 0.215
Echinococcus multilocularis tyrosine protein kinase Src64B 0.042 0.0818 0.093
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0227 0.0319 0.0698
Loa Loa (eye worm) TK/FER protein kinase 0.0201 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.033 0.0586 0.0586
Schistosoma mansoni neuroglian 0.0154 0.0132 0.0381
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0213 0.0284 0.111
Echinococcus multilocularis kinase suppressor of Ras 1 0.0114 0.0027 0.003
Echinococcus multilocularis mitogen activated protein kinase 11 0.1008 0.234 0.2658
Entamoeba histolytica protein kinase domain containing protein 0.0723 0.1602 1
Onchocerca volvulus 0.1165 0.2746 0.2746
Schistosoma mansoni tyrosine protein kinase 0.0114 0.0027 0.0077
Trypanosoma brucei rac serine-threonine kinase, putative 0.0175 0.0187 0.0692
Loa Loa (eye worm) hypothetical protein 0.0149 0.0119 0.0119
Loa Loa (eye worm) RGC/RGC protein kinase 0.0114 0.0027 0.0027
Echinococcus granulosus cyclin dependent kinase 5 0.0298 0.0505 0.1106
Echinococcus multilocularis tyrosine protein kinase pr2 0.0114 0.0027 0.003
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0322 0.0566 0.1239
Loa Loa (eye worm) TK/INSR protein kinase 0.0664 0.1452 0.1452
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0159 0.0145 0.0165
Schistosoma mansoni tyrosine kinase 0.1447 0.3476 1
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0114 0.0027 0.0027
Brugia malayi Immunoglobulin I-set domain containing protein 0.0139 0.0093 0.0093
Echinococcus granulosus roundabout 2 0.0154 0.0132 0.029
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0398 0.1603
Echinococcus multilocularis aurora kinase A 0.0425 0.0833 0.0946
Schistosoma mansoni serine/threonine protein kinase 0.0298 0.0505 0.1453
Schistosoma mansoni protein kinase 0.0695 0.153 0.4402
Loa Loa (eye worm) hypothetical protein 0.027 0.043 0.043
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0723 0.1602 0.6813
Brugia malayi Immunoglobulin I-set domain containing protein 0.1635 0.3961 0.3961
Trichomonas vaginalis CMGC family protein kinase 0.0471 0.0952 0.6169
Echinococcus granulosus dual specificity testis-specific protein kinase 0.1 0.232 0.5079
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0114 0.0027 0.0027
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0152 0.0125 0.036
Trichomonas vaginalis CAMK family protein kinase 0.0163 0.0154 0.0848
Loa Loa (eye worm) hypothetical protein 0.0139 0.0093 0.0093
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0473 0.2976
Schistosoma mansoni serine/threonine protein kinase 0.0163 0.0154 0.0443
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0114 0.0027 0.003
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0321 0.0563 0.0563
Brugia malayi Protein kinase domain containing protein 0.0753 0.168 0.168
Loa Loa (eye worm) plexin A 0.0142 0.01 0.01
Loa Loa (eye worm) TK/FER protein kinase 0.0114 0.0027 0.0027
Echinococcus multilocularis roundabout 2 0.0459 0.0921 0.1047
Schistosoma mansoni serine/threonine protein kinase 0.0171 0.0175 0.0502
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.0135 0.0389
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0775 0.1738 0.1974
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0227 0.0319 0.2441
Trichomonas vaginalis CAMK family protein kinase 0.0163 0.0154 0.0848
Plasmodium falciparum protein serine/threonine kinase-1 0.0576 0.1224 1
Brugia malayi Hr1 repeat family protein 0.0159 0.0145 0.0145
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0438 0.0866 0.363
Brugia malayi Immunoglobulin I-set domain containing protein 0.0154 0.0132 0.0132
Brugia malayi Receptor family ligand binding region containing protein 0.0114 0.0027 0.0027
Echinococcus granulosus protein tyrosine kinase 0.1447 0.3476 0.7608
Loa Loa (eye worm) hypothetical protein 0.0356 0.0654 0.0654
Brugia malayi hypothetical protein 0.0213 0.0284 0.0284
Schistosoma mansoni serine/threonine protein kinase 0.0911 0.209 0.6012
Onchocerca volvulus 0.0119 0.0042 0.0042
Trypanosoma cruzi casein kinase, putative 0.0271 0.0434 0.1763
Trichomonas vaginalis AGC family protein kinase 0.0176 0.0189 0.1084
Schistosoma mansoni tyrosine kinase 0.0114 0.0027 0.0077
Entamoeba histolytica protein kinase, putative 0.0723 0.1602 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0471 0.0952 0.0952
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0576 0.1224 0.5176
Schistosoma mansoni tyrosine kinase 0.091 0.2088 0.6006
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.0145 0.0418
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0248 0.0376 0.0427
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0255 0.0391 0.0445
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.0145 0.0418
Echinococcus granulosus tyrosine kinase 0.0201 0.0252 0.0552
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0114 0.0027 0.0027
Echinococcus granulosus tyrosine protein kinase otk 0.0139 0.0093 0.0204
Schistosoma mansoni septate junction protein 0.0139 0.0093 0.0268
Plasmodium falciparum calcium-dependent protein kinase 3 0.0227 0.0319 0.2441
Toxoplasma gondii AGC kinase 0.0322 0.0566 0.4504
Schistosoma mansoni protein kinase 0.0425 0.0833 0.2396
Echinococcus granulosus activin receptor type 0.1727 0.42 0.9194
Entamoeba histolytica protein kinase, putative 0.0268 0.0426 0.2536
Echinococcus multilocularis dual specificity 0.0723 0.1602 0.1821
Schistosoma mansoni cell adhesion molecule 0.0371 0.0694 0.1996
Loa Loa (eye worm) hypothetical protein 0.0139 0.0093 0.0093
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0322 0.0566 0.4504
Schistosoma mansoni hypothetical protein 0.0149 0.0119 0.0343
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0114 0.0027 0.0077
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0555 0.1169 0.1169
Entamoeba histolytica serine/threonine protein kinase, putative 0.0163 0.0154 0.0807
Echinococcus multilocularis geminin 0.0205 0.0262 0.0298
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0271 0.0434 0.1763
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0114 0.0027 0.000000026049
Trichomonas vaginalis STE family protein kinase 0.0693 0.1526 1
Echinococcus granulosus mitogen activated protein kinase 11 0.1008 0.234 0.5122
Loa Loa (eye worm) TK/FER protein kinase 0.0114 0.0027 0.0027
Echinococcus granulosus tyrosine protein kinase Src42A 0.0248 0.0376 0.0822
Trichomonas vaginalis STE family protein kinase 0.0134 0.0079 0.0347
Echinococcus granulosus c src tyrosine kinase 0.0265 0.0419 0.0916
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0134 0.0079 0.0089
Entamoeba histolytica protein kinase, putative 0.015 0.012 0.0592
Echinococcus multilocularis c src tyrosine kinase 0.0265 0.0419 0.0476
Schistosoma mansoni vam6/vps39 related 0.0213 0.0284 0.0816
Schistosoma mansoni kinase 0.0164 0.0157 0.0453
Brugia malayi Protein kinase domain containing protein 0.0911 0.209 0.209
Brugia malayi casein kinase 1, delta 0.0271 0.0434 0.0434
Echinococcus multilocularis transfer RNA-Thr 0.0814 0.1838 0.2088
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0753 0.168 0.168
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0326 0.0575 0.0575
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0425 0.0833 0.6733
Trypanosoma brucei cdc2-related kinase 3 0.0298 0.0505 0.2068
Brugia malayi cyclin-dependent kinase 7 homolog 0.0409 0.0791 0.0791
Echinococcus multilocularis rho associated protein kinase 0.0684 0.1501 0.1705
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0213 0.0284 0.111
Onchocerca volvulus 0.0114 0.0027 0.0027
Schistosoma mansoni tyrosine kinase 0.0114 0.0027 0.0077
Echinococcus granulosus mitogen activated protein kinase 14 0.1008 0.234 0.5122
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0227 0.0319 0.2441
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0159 0.0145 0.0318
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0753 0.168 0.168
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Brugia malayi cyclin-dependent kinase 9 0.0164 0.0157 0.0157
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0114 0.0027 0.0058
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0163 0.0154 0.055
Trichomonas vaginalis STE family protein kinase 0.0503 0.1033 0.6713
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0576 0.1224 0.5176
Plasmodium vivax casein kinase 1, putative 0.0271 0.0434 0.3406
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0114 0.0027 0.003
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0115 0.0031 0.0026
Trypanosoma cruzi cdc2-related kinase 1 0.0298 0.0505 0.2068
Plasmodium falciparum calcium-dependent protein kinase 5 0.0227 0.0319 0.2441
Plasmodium vivax calcium-dependent protein kinase, putative 0.0227 0.0319 0.2441
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.0048 0.0137
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0322 0.0566 0.0643
Echinococcus granulosus geminin 0.0205 0.0262 0.0574
Loa Loa (eye worm) TK/FER protein kinase 0.0201 0.0252 0.0252
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0201 0.0252 0.0287
Schistosoma mansoni serine/threonine protein kinase 0.0271 0.0434 0.125
Trichomonas vaginalis TKL family protein kinase 0.0114 0.0027 0.000000026049
Echinococcus multilocularis tyrosine protein kinase Fyn 0.042 0.0818 0.093
Echinococcus multilocularis protein kinase c iota type 0.0215 0.029 0.0329
Echinococcus granulosus serine:threonine protein kinase N2 0.0159 0.0145 0.0318
Loa Loa (eye worm) hypothetical protein 0.0655 0.1428 0.1428
Schistosoma mansoni cell adhesion molecule 0.0154 0.0132 0.0381
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0569 0.1205 0.1369
Echinococcus multilocularis tyrosine protein kinase Fyn 0.042 0.0818 0.093
Echinococcus granulosus NCK adaptor protein 0.0152 0.0125 0.0274
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.012 0.0044 0.0096
Onchocerca volvulus 0.0149 0.0119 0.0119
Echinococcus multilocularis cyclin dependent kinase 5 0.0298 0.0505 0.0574
Leishmania major protein kinase A catalytic subunit isoform 2 0.0322 0.0566 0.2331
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0298 0.0505 0.1106
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0576 0.1224 1
Loa Loa (eye worm) AUR protein kinase 0.0425 0.0833 0.0833
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0326 0.0575 0.0575
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.1285 0.3057 0.3473
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0114 0.0027 0.0058
Schistosoma mansoni tyrosine kinase 0.0988 0.2289 0.6586
Loa Loa (eye worm) TK/FER protein kinase 0.0114 0.0027 0.0027
Echinococcus granulosus tyrosine protein kinase csk 0.0114 0.0027 0.0058
Schistosoma mansoni hypothetical protein 0.0213 0.0284 0.0816
Onchocerca volvulus 0.0114 0.0027 0.0027
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0114 0.0027 0.0027
Brugia malayi Protein kinase domain containing protein 0.0576 0.1224 0.1224
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Echinococcus multilocularis cyclin dependent kinase 9 0.0181 0.0201 0.0229
Loa Loa (eye worm) AGC/NDR protein kinase 0.0159 0.0145 0.0145
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0503 0.1033 0.8406
Trichomonas vaginalis CK1 family protein kinase 0.0271 0.0434 0.272
Echinococcus granulosus tyrosine protein kinase 0.0114 0.0027 0.0058
Echinococcus multilocularis tyrosine protein kinase Fyn 0.042 0.0818 0.093
Schistosoma mansoni serine/threonine protein kinase 0.0336 0.0602 0.1733
Brugia malayi integrin-linked kinase 0.0114 0.0027 0.0027
Schistosoma mansoni tyrosine kinase 0.0114 0.0027 0.0077
Echinococcus multilocularis MAM 0.0149 0.0119 0.0135
Trichomonas vaginalis STE family protein kinase 0.0693 0.1526 1
Trichomonas vaginalis AGC family protein kinase 0.0159 0.0145 0.0792
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0227 0.0319 0.0362
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0298 0.0505 0.2068
Echinococcus multilocularis casein kinase I delta 0.0271 0.0434 0.0494
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0298 0.0505 0.3996
Echinococcus granulosus calcium dependent protein kinase 0.0159 0.0144 0.0316
Loa Loa (eye worm) hypothetical protein 0.0383 0.0724 0.0724
Onchocerca volvulus 0.0142 0.0102 0.0102
Entamoeba histolytica protein kinase, putative 0.0227 0.0319 0.1855
Echinococcus multilocularis tyrosine protein kinase Src42A 0.042 0.0818 0.093
Schistosoma mansoni protein kinase 0.0271 0.0434 0.125
Echinococcus multilocularis protein KINase family member (kin 25) 0.0383 0.0724 0.0822
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0154 0.0132 0.015
Loa Loa (eye worm) TK/ACK protein kinase 0.0114 0.0027 0.0027
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0179 0.5
Schistosoma mansoni tyrosine kinase 0.018 0.0198 0.0569
Echinococcus granulosus beta-adrenergic receptor kinase 0.0122 0.0048 0.0105
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0114 0.0027 0.0027
Brugia malayi Protein kinase c protein 2 0.0123 0.0052 0.0052
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0201 0.0254 0.0289
Echinococcus multilocularis integrin linked protein kinase 0.0114 0.0027 0.003
Echinococcus granulosus lachesin 0.0139 0.0093 0.0204
Loa Loa (eye worm) AGC/PKA protein kinase 0.0322 0.0566 0.0566
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0362 0.0668 0.1463
Schistosoma mansoni tyrosine kinase 0.0248 0.0375 0.1079
Entamoeba histolytica protein kinase, putative 0.0159 0.0145 0.0754
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0159 0.0145 0.0145
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0322 0.0566 0.2331
Schistosoma mansoni protein kinase 0.0181 0.0201 0.0579
Brugia malayi Protein kinase domain containing protein 0.2531 0.628 0.628
Onchocerca volvulus 0.0201 0.0252 0.0252
Loa Loa (eye worm) TK protein kinase 0.0114 0.0027 0.0027
Echinococcus multilocularis calcium dependent protein kinase 0.0159 0.0144 0.0164
Schistosoma mansoni tyrosine kinase 0.0265 0.0419 0.1205
Loa Loa (eye worm) hypothetical protein 0.0114 0.0027 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0322 0.0566 0.1628
Entamoeba histolytica PH domain containing protein kinase, putative 0.0338 0.0607 0.3684
Loa Loa (eye worm) TK protein kinase 0.0114 0.0027 0.0027
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0322 0.0566 0.2331
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0114 0.0027 0.0058
Onchocerca volvulus 0.0164 0.0159 0.0159
Trichomonas vaginalis AGC family protein kinase 0.0503 0.1033 0.6713
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0468 0.0944 0.0944
Echinococcus granulosus rho-associated protein kinase 1 0.0684 0.1501 0.3286
Loa Loa (eye worm) hypothetical protein 0.0139 0.0093 0.0093
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0911 0.209 0.209
Echinococcus granulosus cyclin dependent kinase 7 0.0392 0.0747 0.1636
Entamoeba histolytica hypothetical protein 0.0116 0.0032 0.0033
Brugia malayi Protein kinase domain containing protein 0.0298 0.0505 0.0505
Schistosoma mansoni protein kinase 0.0114 0.0027 0.0077
Echinococcus multilocularis cyclin dependent kinase 9 0.0164 0.0157 0.0179
Loa Loa (eye worm) TK/FER protein kinase 0.0114 0.0027 0.0027
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0322 0.0566 0.0643
Echinococcus granulosus c-Jun N-terminal kinases 0.1043 0.2431 0.5321
Entamoeba histolytica protein kinase, putative 0.0134 0.0079 0.033
Giardia lamblia Kinase, CAMK CAMKL 0.018 0.0198 0.1141
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.0048 0.0137
Brugia malayi Protein kinase domain containing protein 0.0114 0.0027 0.0027
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0471 0.0952 0.2738
Brugia malayi Protein kinase domain containing protein 0.0664 0.1452 0.1452
Onchocerca volvulus Slit protein homolog 0.0121 0.0046 0.0046
Brugia malayi putative serine/threonine kinase SADA gamma 0.0163 0.0154 0.0154
Trichomonas vaginalis STE family protein kinase 0.0134 0.0079 0.0347
Brugia malayi Immunoglobulin I-set domain containing protein 0.032 0.0561 0.0561
Echinococcus multilocularis insulin receptor 0.0664 0.1452 0.1649
Plasmodium vivax glycogen synthase kinase 3, putative 0.0471 0.0952 0.7725
Echinococcus multilocularis tyrosine protein kinase otk 0.0139 0.0093 0.0106
Schistosoma mansoni protein kinase 0.0114 0.0027 0.0077
Brugia malayi RhoGAP domain containing protein 0.0143 0.0103 0.0103
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0723 0.1602 0.6813
Brugia malayi protein unc-22 0.0171 0.0175 0.0175
Brugia malayi Furin-like cysteine rich region family protein 0.0362 0.0668 0.0668
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0181 0.0201 0.0755
Echinococcus granulosus epidermal growth factor receptor 0.0362 0.0668 0.1463
Echinococcus multilocularis peroxidasin 0.0141 0.0097 0.011
Loa Loa (eye worm) hypothetical protein 0.0509 0.1049 0.1049
Brugia malayi serine/threonine-protein kinase PAK 7 0.0841 0.1909 0.1909
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0555 0.1169 0.1169
Plasmodium vivax protein kinase Crk2 0.0298 0.0505 0.3996
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0114 0.0027 0.003
Echinococcus granulosus TGF-beta receptor type-1 0.037 0.0691 0.1512
Echinococcus multilocularis serine:threonine protein kinase N2 0.0159 0.0145 0.0165
Entamoeba histolytica protein kinase, putative 0.0115 0.0031 0.0026
Echinococcus multilocularis tyrosine kinase 0.0201 0.0252 0.0287
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0122 0.0048 0.0048
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0749 0.1669 0.1896
Echinococcus multilocularis roundabout 2 0.0154 0.0132 0.015
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.0952 0.587
Echinococcus granulosus titin 0.0171 0.0175 0.0382
Brugia malayi Protein kinase domain 0.0134 0.0079 0.0079
Echinococcus granulosus hypothetical protein 0.0509 0.1049 0.2297
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0693 0.1526 0.1526
Brugia malayi Protein kinase domain containing protein 0.0175 0.0187 0.0187
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1008 0.234 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.042 0.0818 0.1791
Echinococcus multilocularis cyclin dependent kinase 1 0.0298 0.0505 0.0574
Brugia malayi hypothetical protein 0.1285 0.3057 0.3057
Loa Loa (eye worm) hypothetical protein 0.0303 0.0516 0.0516
Loa Loa (eye worm) TK/ALK protein kinase 0.253 0.6278 0.6278
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0227 0.0319 0.2441
Echinococcus multilocularis protein kinase c epsilon type 0.0215 0.029 0.0329
Loa Loa (eye worm) hypothetical protein 0.0141 0.0097 0.0097
Schistosoma mansoni serine/threonine protein kinase 0.0163 0.0154 0.0443
Echinococcus granulosus cyclin dependent kinase 9 0.0164 0.0157 0.0345

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 107.99 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7407 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Saccharomyces cerevisiae ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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