Detailed information for compound 1379126

Basic information

Technical information
  • TDR Targets ID: 1379126
  • Name: 1-[2-(4-methoxyphenoxy)ethylsulfanyl]-[1,2,4] triazolo[3,4-b][1,3]benzothiazole
  • MW: 357.45 | Formula: C17H15N3O2S2
  • H donors: 0 H acceptors: 2 LogP: 5.18 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)OCCSc1nnc2n1c1ccccc1s2
  • InChi: 1S/C17H15N3O2S2/c1-21-12-6-8-13(9-7-12)22-10-11-23-16-18-19-17-20(16)14-4-2-3-5-15(14)24-17/h2-9H,10-11H2,1H3
  • InChiKey: CFGZDYLHKGUMKS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-(4-methoxyphenoxy)ethylthio]-[1,2,4]triazolo[3,4-b][1,3]benzothiazole
  • ZINC03495532
  • T5422464
  • MLS000057941
  • SMR000065011

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Schistosoma mansoni neuropeptide receptor 0.0011 0.0015 0.0015
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.009 0.0087
Plasmodium vivax hypothetical protein, conserved 0.0036 0.009 0.6787
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0036 0.2544
Echinococcus granulosus neuropeptide s receptor 0.0011 0.0015 0.0012
Echinococcus multilocularis vesicular acetylcholine transporter 0.3392 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0015 0.0012
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.003 0.2001
Brugia malayi Melatonin receptor type 1A 0.0011 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0038 0.0038
Trichomonas vaginalis alpha-glucosidase, putative 0.0066 0.0177 0.2536
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0036 0.0502
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.003 0.0035
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0011 0.0015 0.0015
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.0666 0.0663
Entamoeba histolytica hypothetical protein, conserved 0.0155 0.044 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0036 0.0043
Echinococcus multilocularis G protein coupled receptor 139 0.0011 0.0015 0.0012
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0008 0.0263
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0067 0.0064
Schistosoma mansoni adenoreceptor 0.0011 0.0015 0.0015
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0011 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0038 0.0045
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.009 0.1302
Leishmania major trypanothione reductase 0.0047 0.0121 0.0153
Loa Loa (eye worm) hypothetical protein 0.0036 0.009 0.0087
Schistosoma mansoni hypothetical protein 0.0506 0.1477 0.1477
Onchocerca volvulus 0.0036 0.009 0.0075
Schistosoma mansoni hypothetical protein 0.0011 0.0015 0.0015
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0066 0.0177 0.9844
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0038 0.0524
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0295 0.0854 0.0852
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0035
Toxoplasma gondii ABC1 family protein 0.0036 0.009 0.4928
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.009 0.0087
Echinococcus granulosus g-protein coupled receptor 0.0011 0.0015 0.0012
Schistosoma mansoni ap endonuclease 0.0018 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0155 0.044 0.0437
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0596 0.0594
Echinococcus granulosus fmrfamide receptor 0.0011 0.0015 0.0012
Brugia malayi Pre-SET motif family protein 0.0208 0.0596 0.0594
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0121 0.0119
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.003 0.0627
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0015 0.0012
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.0015 0.0012
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.003 0.0666
Trypanosoma brucei unspecified product 0.0013 0.0021 0.0023
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0011 0.0015 0.0012
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0038 0.0524
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0072 0.0072
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.009 0.1302
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0036 0.0043
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0011 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0038 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0015 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0015 0.0015
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0299 0.4439
Leishmania major DNA polymerase kappa, putative 0.0019 0.0038 0.0045
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0095 0.1885
Schistosoma mansoni opsin-like receptor 0.0011 0.0015 0.0015
Echinococcus multilocularis serotonin receptor 0.0011 0.0015 0.0012
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0121 0.1771
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0015 0.0012
Plasmodium vivax glutathione reductase, putative 0.0047 0.0121 1
Echinococcus multilocularis neuropeptide receptor A26 0.0011 0.0015 0.0012
Schistosoma mansoni cpg binding protein 0.0037 0.009 0.009
Trypanosoma brucei glycosyl hydrolase-like protein 0.0038 0.0095 0.0119
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0036 0.0043
Mycobacterium leprae conserved hypothetical protein 0.0036 0.009 0.2621
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0015 0.0012
Onchocerca volvulus 0.0158 0.0448 0.0434
Toxoplasma gondii thioredoxin reductase 0.0047 0.0121 0.67
Loa Loa (eye worm) hypothetical protein 0.0036 0.009 0.0087
Brugia malayi Serotonin receptor 0.0011 0.0015 0.0012
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0038 0.0801
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0044 0.0041
Schistosoma mansoni sodium-dependent amino acid transporter 0.0027 0.0061 0.0061
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0038 0.0801
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0011 0.0015 0.0015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0005 0.00000000015537
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0299 0.8933
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0038 0.0095 0.0092
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.003 0.0035
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0036 0.0504
Schistosoma mansoni growth hormone secretagogue receptor 0.0011 0.0015 0.0015
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0027 0.0061 0.0058
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0035
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0036 0.0034
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0061 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0045
Trypanosoma brucei unspecified product 0.0019 0.0038 0.0045
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0299 0.4439
Brugia malayi Serotonin receptor 0.0011 0.0015 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0015 0.0012
Schistosoma mansoni hypothetical protein 0.0007 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0072 0.0072
Mycobacterium tuberculosis Conserved protein 0.0155 0.044 0.654
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0061 0.384
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0027 0.0061 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0011 0.0015 0.0012
Schistosoma mansoni vesicular acetylcholine transporter 0.3392 1 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.0061 0.0061
Schistosoma mansoni sodium/chloride dependent transporter 0.0158 0.0448 0.0448
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0038 0.0045
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0036 0.0034
Echinococcus granulosus lysosomal alpha glucosidase 0.0295 0.0854 0.0852
Echinococcus multilocularis synaptic vesicular amine transporter 0.0187 0.0534 0.0531
Echinococcus granulosus neuropeptide receptor 0.0011 0.0015 0.0012
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Echinococcus multilocularis lysosomal alpha glucosidase 0.0295 0.0854 0.0852
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0015 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.009 0.0112
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0335 0.4969
Mycobacterium ulcerans beta-lactamase 0.0036 0.009 0.1991
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0061 0.0061
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0038 0.0482
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0121 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0011 0.0015 0.0015
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.1441 0.1438
Leishmania major hypothetical protein, conserved 0.0036 0.009 0.0112
Brugia malayi hypothetical protein 0.0011 0.0015 0.0012
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0158 0.0448 0.0448
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0015 0.0012
Echinococcus granulosus somatostatin receptor 0.0011 0.0015 0.0012
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.0061 0.0061
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0011 0.0015 0.0012
Schistosoma mansoni hypothetical protein 0.0011 0.0015 0.0015
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0015 0.0012
Echinococcus multilocularis cpg binding protein 0.0037 0.009 0.0087
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.003 0.0666
Echinococcus granulosus hypothetical protein 0.0011 0.0015 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0045
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0095 0.1328
Onchocerca volvulus Huntingtin homolog 0.0148 0.0419 0.0405
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Loa Loa (eye worm) RNA binding protein 0.0076 0.0208 0.0205
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Onchocerca volvulus 0.0036 0.009 0.0075
Trichomonas vaginalis alpha-glucosidase, putative 0.0066 0.0177 0.2536
Schistosoma mansoni ap endonuclease 0.0018 0.0036 0.0036
Echinococcus granulosus neuropeptide receptor 0.0011 0.0015 0.0012
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0015 0.0012
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0015 0.0015
Brugia malayi hypothetical protein 0.0011 0.0015 0.0012
Echinococcus multilocularis neutral alpha glucosidase AB 0.0066 0.0177 0.0174
Onchocerca volvulus 0.0035 0.0085 0.007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.0015 0.0012
Brugia malayi RNA binding protein 0.0076 0.0208 0.0205
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.009 0.009
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0061 0.0058
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.0058
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0005
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0011 0.0015 0.0012
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.009 0.1302
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0015 0.0012
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0011 0.0015 0.0015
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0011 0.0015 0.0012
Echinococcus granulosus serotonin receptor 0.0011 0.0015 0.0012
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.003 0.0035
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.0061 0.0058
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0015 0.0015
Onchocerca volvulus 0.0027 0.0061 0.0046
Echinococcus multilocularis dro:myosuppressin receptor 0.0011 0.0015 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0072 0.0072
Plasmodium vivax SET domain protein, putative 0.003 0.0072 0.4964
Echinococcus granulosus neuropeptide FF receptor 2 0.0011 0.0015 0.0012
Onchocerca volvulus 0.0237 0.0681 0.0667
Echinococcus multilocularis dna polymerase eta 0.0019 0.0038 0.0035
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0008 0.0005
Brugia malayi G-protein coupled receptor 0.0011 0.0015 0.0012
Echinococcus multilocularis orexin receptor type 2 0.0011 0.0015 0.0012
Schistosoma mansoni hypothetical protein 0.0506 0.1477 0.1477
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0015 0.0016
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0038 0.0095 0.0119
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0038 0.0045
Brugia malayi Glycosyl hydrolases family 31 protein 0.0066 0.0177 0.0174
Plasmodium falciparum thioredoxin reductase 0.0016 0.003 0.2001
Brugia malayi hypothetical protein 0.0011 0.0015 0.0012
Mycobacterium tuberculosis Probable reductase 0.0107 0.0299 0.4439
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0038 0.0035
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0015 0.0012
Schistosoma mansoni DNA polymerase eta 0.0019 0.0038 0.0038
Brugia malayi ERG2 and Sigma1 receptor like protein 0.2628 0.7745 0.7744
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0066 0.0177 0.0174
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0015 0.0012
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0038 0.0482
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Brugia malayi Abnormal catecholamine distribution protein 1 0.0187 0.0534 0.0531
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0015 0.0015
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0036 0.0461
Echinococcus granulosus G protein coupled receptor 139 0.0011 0.0015 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0045
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0011 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0231 0.0666 0.0663
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0208 0.0208
Schistosoma mansoni biogenic amine receptor 0.0011 0.0015 0.0015
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.003 0.2001
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.0061 0.0058
Brugia malayi Dopamine receptor 0.0011 0.0015 0.0012
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0027 0.0061 0.0058
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0015 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0045
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Echinococcus granulosus tumor protein p63 0.0408 0.1187 0.1185
Schistosoma mansoni amine GPCR 0.0011 0.0015 0.0015
Leishmania major DNA polymerase eta, putative 0.0019 0.0038 0.0045
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0095 0.1328
Brugia malayi Glycosyl hydrolases family 31 protein 0.0295 0.0854 0.0852
Echinococcus multilocularis sphingosine kinase 1 0.0155 0.044 0.0437
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0072 0.0069
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Schistosoma mansoni cytochrome P450 0.0007 0.0003 0.0003
Brugia malayi GnHR receptor homolog 0.0011 0.0015 0.0012
Brugia malayi hypothetical protein 0.0011 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.0058
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.0015 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0045
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0158 0.0448 0.0445
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0035
Echinococcus granulosus dna polymerase kappa 0.0019 0.0038 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0045
Loa Loa (eye worm) solute carrier family 6 member 4 0.0158 0.0448 0.0445
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.0061 0.0061
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0038 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0005 0.00000000015537
Loa Loa (eye worm) hypothetical protein 0.006 0.0158 0.0156
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0038 0.0038
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0066 0.0177 0.3806
Schistosoma mansoni amine GPCR 0.0011 0.0015 0.0015
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.0015 0.0012
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0015 0.0012
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.003 0.0027
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.003 0.003
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0015 0.0015
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0015 0.0012
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.0015 0.0012
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0299 0.4439
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0179 1
Echinococcus granulosus dnaJ subfamily B 0.0494 0.1441 0.1438
Brugia malayi sulfakinin receptor protein 0.0011 0.0015 0.0012
Schistosoma mansoni cpg binding protein 0.0037 0.009 0.009
Trichomonas vaginalis alpha-glucosidase, putative 0.0066 0.0177 0.2536
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.009 0.1252
Mycobacterium ulcerans hypothetical protein 0.0155 0.044 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0011 0.0015 0.0015
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0095 0.1328
Brugia malayi neuropeptide F receptor 0.0011 0.0015 0.0012
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0095 0.0092
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0005 0.00000000015537
Echinococcus multilocularis geminin 0.0506 0.1477 0.1475
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0011 0.0011
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.009 0.1302
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0015 0.0012
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0072 0.0069
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0038 0.0045
Brugia malayi TAR-binding protein 0.0076 0.0208 0.0205
Echinococcus multilocularis g-protein coupled receptor 0.0011 0.0015 0.0012
Echinococcus granulosus vesicular acetylcholine transporter 0.3392 1 1
Onchocerca volvulus 0.0027 0.0061 0.0046
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0015 0.0015
Echinococcus granulosus synaptic vesicular amine transporter 0.0187 0.0534 0.0531
Schistosoma mansoni hypothetical protein 0.0047 0.0121 0.0121
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0015 0.0016
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0015 0.0144
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0027 0.0061 0.0058
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.0015 0.0012
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0187 0.0534 0.0531
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.0061 0.0058
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0015 0.0012
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0008 0.0005
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0044 0.0041
Echinococcus granulosus peptide allatostatin:somatostatin 0.0011 0.0015 0.0012
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.0058
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0015 0.0012
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0011 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.0058
Schistosoma mansoni amine GPCR 0.0011 0.0015 0.0015
Plasmodium falciparum glutathione reductase 0.0047 0.0121 1
Brugia malayi beta-lactamase family protein 0.0036 0.009 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0038 0.0045
Brugia malayi hypothetical protein 0.0011 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0015 0.0012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0017 0.0014
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0017 0.0015
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0015 0.0012
Leishmania major alpha glucosidase II subunit, putative 0.0066 0.0177 0.0224
Echinococcus multilocularis allatostatin A receptor 0.0011 0.0015 0.0012
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.0061 0.0058
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0005 0.00000000015537
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0177 0.0224
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.009 0.1302
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.0015 0.0012
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0038 0.0035
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.003 0.041
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0177 0.0224
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0095 0.1328
Loa Loa (eye worm) norepinephrine transporter 0.0158 0.0448 0.0445
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.0058
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.009 0.1302
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0038 0.0035
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0036 0.0461
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0035
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0015 0.0012
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.003 0.0027
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.003 0.0627
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0044 0.0569
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0015 0.0012
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0095 0.1328
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0021 0.0023
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0038 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0015 0.0015
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.0015 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0005 0.00000000015537
Mycobacterium tuberculosis Conserved protein 0.0036 0.009 0.1302
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0335 0.4969
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0061 0.0058
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0061 0.3302
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0015 0.0012
Brugia malayi Dopamine receptor protein 1 0.0011 0.0015 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0005 0.00000000015537
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.0061 0.0058
Echinococcus multilocularis lysosomal alpha glucosidase 0.0295 0.0854 0.0852
Brugia malayi putative neuropeptide receptor 0.0011 0.0015 0.0012
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0036 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0045
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0095 0.1328
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0017 0.0014
Schistosoma mansoni biogenic amine receptor 0.0011 0.0015 0.0015
Trichomonas vaginalis set domain proteins, putative 0.0237 0.0681 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0158 0.0448 0.0445
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0121 0.0118
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.009 0.1991
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0021 0.0023
Brugia malayi G-protein coupled receptor 0.0011 0.0015 0.0012
Brugia malayi beta-lactamase family protein 0.0036 0.009 0.0087
Mycobacterium tuberculosis Conserved protein 0.0036 0.009 0.1302
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0011 0.0015 0.0012
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0031 0.0031
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0335 0.4969
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0011 0.0015 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0015 0.0015
Onchocerca volvulus 0.0036 0.009 0.0075
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0121 0.0118
Echinococcus granulosus tm gpcr rhodopsin 0.0536 0.1564 0.1562
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.0666 0.0663
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0017 0.0014
Echinococcus granulosus neuropeptide receptor A26 0.0011 0.0015 0.0012
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0011 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0208 0.0208
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0015 0.0015
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0015 0.0012
Plasmodium falciparum glutathione reductase 0.0016 0.003 0.2001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0015 0.0012
Leishmania major glycosyl hydrolase-like protein 0.0038 0.0095 0.0119
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0061 0.0061
Mycobacterium ulcerans lipase LipD 0.0036 0.009 0.1991
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.009 0.1252
Loa Loa (eye worm) serotonin transporter b 0.0158 0.0448 0.0445
Loa Loa (eye worm) RecQ helicase 0.0021 0.0044 0.0041
Schistosoma mansoni opsin-like receptor 0.0011 0.0015 0.0015
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0036 0.9531
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.003 0.0035
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.003 0.0035
Mycobacterium leprae Probable lipase LipE 0.0036 0.009 0.2621
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0208 0.0205
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Brugia malayi glutathione reductase 0.0047 0.0121 0.0118
Schistosoma mansoni hypothetical protein 0.0494 0.1441 0.1441
Echinococcus granulosus geminin 0.0506 0.1477 0.1475
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0066 0.0177 0.2536
Loa Loa (eye worm) hypothetical protein 0.0158 0.0448 0.0445
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0027 0.0061 0.0058
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0036 0.0148
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0038 0.0045
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0023 0.1155
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0044 0.0569
Brugia malayi hypothetical protein 0.0011 0.0015 0.0012
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0038 0.0538
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.009 0.1991
Echinococcus granulosus serotonin transporter 0.0158 0.0448 0.0445
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0208 0.0205
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0015 0.0012
Brugia malayi hypothetical protein 0.0148 0.0419 0.0416
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0015 0.0015
Echinococcus granulosus tar DNA binding protein 0.0076 0.0208 0.0205
Plasmodium falciparum transporter, putative 0.0027 0.0061 0.4721
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0038 0.0045
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0015 0.0012
Echinococcus granulosus orexin receptor type 2 0.0011 0.0015 0.0012
Schistosoma mansoni amine GPCR 0.0011 0.0015 0.0015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0015 0.0012
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.3392 1 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.009 0.1991
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.0061 0.0058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0005 0.00000000015537
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0061 0.3302
Brugia malayi Thioredoxin reductase 0.0047 0.0121 0.0118
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Schistosoma mansoni biogenic amine receptor 0.0011 0.0015 0.0015
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.003 0.037
Brugia malayi hypothetical protein 0.0011 0.0015 0.0012
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.003 0.7497
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0036 0.0768
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0121 0.0118
Brugia malayi Pre-SET motif family protein 0.003 0.0072 0.0069
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0027 0.0061 0.0058
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.009 0.1302
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0008 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0015 0.0012
Echinococcus granulosus g protein coupled receptor 0.0011 0.0015 0.0012
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0036 0.009 0.0087
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0008 0.0005
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.009 0.1252
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0045
Trichomonas vaginalis maltase-glucoamylase, putative 0.0066 0.0177 0.2536
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0017 0.0014
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0011 0.0015 0.0012
Brugia malayi hypothetical protein 0.0011 0.0015 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0015 0.0015
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0015 0.0012
Echinococcus granulosus dna polymerase eta 0.0019 0.0038 0.0035
Schistosoma mansoni histamine h1 receptor 0.0011 0.0015 0.0015
Onchocerca volvulus Huntingtin homolog 0.0148 0.0419 0.0405
Brugia malayi neuropeptide F receptor 0.0011 0.0015 0.0012
Brugia malayi larval opioid receptor 0.0011 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.009 0.0087
Trichomonas vaginalis alpha-glucosidase, putative 0.0066 0.0177 0.2536
Loa Loa (eye worm) hypothetical protein 0.0148 0.0419 0.0416
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.003 0.0627
Loa Loa (eye worm) hypothetical protein 0.003 0.0072 0.0069
Plasmodium falciparum thioredoxin reductase 0.0047 0.0121 1
Toxoplasma gondii exonuclease III APE 0.0018 0.0036 0.1901
Brugia malayi beta-lactamase 0.0036 0.009 0.0087
Onchocerca volvulus 0.006 0.0158 0.0144
Schistosoma mansoni hypothetical protein 0.0011 0.0015 0.0015
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0208 0.0205
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0061 0.0061
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0036 0.2528
Schistosoma mansoni sphingosine kinase A B 0.0155 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Trichomonas vaginalis alpha-glucosidase, putative 0.0066 0.0177 0.2536
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0061 0.0058
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Trypanosoma brucei glucosidase, putative 0.0066 0.0177 0.0224
Echinococcus granulosus 7tm_1 domain containing protein 0.0011 0.0015 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0045
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Schistosoma mansoni sphingoid long chain base kinase 0.0155 0.044 0.044
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0208 0.0208
Schistosoma mansoni alpha-glucosidase 0.0268 0.0773 0.0773
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0095 0.1328
Trypanosoma brucei unspecified product 0.0013 0.0021 0.0023
Schistosoma mansoni vesicular amine transporter 0.0187 0.0534 0.0534
Schistosoma mansoni neuropeptide receptor 0.0011 0.0015 0.0015
Echinococcus granulosus g protein coupled receptor 0.0011 0.0015 0.0012
Toxoplasma gondii hypothetical protein 0.0027 0.0061 0.3302
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0066 0.0177 0.2536
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0066 0.0177 0.3806
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0038 0.0045
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0008 0.0005
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0299 0.4439
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0008 0.0263
Schistosoma mansoni DNA helicase recq1 0.0009 0.0008 0.0008
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Echinococcus granulosus allatostatin A receptor 0.0011 0.0015 0.0012
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0015 0.0012
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0015 0.0012
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0038 0.0045
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0036 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0005 0.00000000015537
Brugia malayi RE15519p 0.0011 0.0015 0.0012
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0299 0.4439
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.3392 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0011 0.0015 0.0012
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0027 0.0061 0.0058
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0061 0.0061
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0011 0.0015 0.0012
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0072 0.0069
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.003 0.1551
Toxoplasma gondii hypothetical protein 0.0027 0.0061 0.3302
Onchocerca volvulus 0.0027 0.0061 0.0046
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.0015 0.0012
Loa Loa (eye worm) glutathione reductase 0.0047 0.0121 0.0118
Onchocerca volvulus 0.003 0.0072 0.0057
Loa Loa (eye worm) hypothetical protein 0.0036 0.009 0.0087
Echinococcus granulosus 7TM GPCR rhodopsin 0.0011 0.0015 0.0012
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.003 0.037
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0035
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0035
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0011 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.009 0.0087
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0061 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0045
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.009 0.009
Onchocerca volvulus 0.0047 0.0121 0.0107
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0015 0.0016
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0335 1
Trichomonas vaginalis esterase, putative 0.0036 0.009 0.1252
Loa Loa (eye worm) hypothetical protein 0.0036 0.009 0.0087
Brugia malayi Dopamine receptor protein 2 0.0011 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.0058
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.009 0.0112
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0015 0.0012
Trichomonas vaginalis sucrase-isomaltase, putative 0.0066 0.0177 0.2536
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.0015 0.0012
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.0061 0.0058
Schistosoma mansoni hypothetical protein 0.0011 0.0015 0.0015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0035
Echinococcus granulosus sex peptide receptor 0.0011 0.0015 0.0012
Echinococcus multilocularis tumor protein p63 0.0408 0.1187 0.1185
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0061 0.3302
Brugia malayi ORL1-like opioid receptor 0.0011 0.0015 0.0012
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0011 0.0015 0.0015
Leishmania major C-8 sterol isomerase-like protein 0.2628 0.7745 1
Schistosoma mansoni amine GPCR 0.0011 0.0015 0.0015
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.003 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.009 0.1252
Loa Loa (eye worm) hypothetical protein 0.2628 0.7745 0.7744
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.009 0.1252
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0036 0.13
Schistosoma mansoni alpha-glucosidase 0.0268 0.0773 0.0773
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.003 0.0035
Plasmodium vivax amine transporter, putative 0.0027 0.0061 0.384
Echinococcus multilocularis serotonin receptor 0.0011 0.0015 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0015 0.0012
Echinococcus granulosus cpg binding protein 0.0037 0.009 0.0087
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.0061 0.0061
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0031 0.0028
Loa Loa (eye worm) hypothetical protein 0.1343 0.395 0.3948
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0015 0.0015
Brugia malayi hypothetical protein 0.0231 0.0666 0.0663
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0036 0.0034
Brugia malayi AKH receptor 0.0011 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0158 0.0448 0.0445
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0095 0.1328
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0011 0.0008
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0072 0.3922
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.068 0.0677
Plasmodium falciparum amino acid transporter, putative 0.0027 0.0061 0.4721
Brugia malayi hypothetical protein 0.0027 0.0061 0.0058
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.0015 0.0012
Schistosoma mansoni opsin-like receptor 0.0011 0.0015 0.0015
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0015 0.0012
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.009 0.0087
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.0058
Loa Loa (eye worm) hypothetical protein 0.0148 0.0419 0.0416
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0072 0.0072
Trypanosoma brucei C-8 sterol isomerase, putative 0.2628 0.7745 1
Trypanosoma brucei trypanothione reductase 0.0047 0.0121 0.0153
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0015 0.0012
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.0015 0.0012
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0015 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0015 0.0012
Schistosoma mansoni DNA helicase recq5 0.0009 0.0008 0.0008
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0536 0.1564 0.1562
Brugia malayi CXXC zinc finger family protein 0.0035 0.0085 0.0082
Echinococcus granulosus neutral alpha glucosidase AB 0.0066 0.0177 0.0174
Schistosoma mansoni neuropeptide receptor 0.0011 0.0015 0.0015
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0008 0.0005
Echinococcus granulosus dro:myosuppressin receptor 0.0011 0.0015 0.0012
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0121 0.0153
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.003 0.0035
Brugia malayi follicle stimulating hormone receptor 0.0236 0.068 0.0677
Mycobacterium tuberculosis Conserved protein 0.0036 0.009 0.1302
Treponema pallidum sodium- and chloride- dependent transporter 0.0158 0.0448 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0011 0.0015 0.0012
Echinococcus granulosus sphingosine kinase 1 0.0155 0.044 0.0437
Echinococcus granulosus tachykinin peptides receptor 99D 0.0011 0.0015 0.0012
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0015 0.0015
Loa Loa (eye worm) beta-lactamase 0.0036 0.009 0.0087
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0015 0.0012
Brugia malayi hypothetical protein 0.0011 0.0015 0.0012
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0038 0.0035
Echinococcus granulosus g protein coupled receptor 0.0011 0.0015 0.0012
Echinococcus granulosus bloom syndrome protein 0.0021 0.0044 0.0041
Schistosoma mansoni alpha glucosidase 0.0066 0.0177 0.0177
Schistosoma mansoni survival motor neuron protein 0.0047 0.0121 0.0121
Echinococcus multilocularis sex peptide receptor 0.0011 0.0015 0.0012
Giardia lamblia DINP protein human, muc B family 0.0019 0.0038 1
Schistosoma mansoni myosin xvIII 0.0011 0.0015 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0208 0.0208
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0021 0.0023
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.0061 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.009 0.0112
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0038 0.0095 0.008
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0035
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0015 0.0012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0203 0.0203
Echinococcus multilocularis neuropeptide s receptor 0.0011 0.0015 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0015 0.0012
Schistosoma mansoni cpg binding protein 0.0035 0.0085 0.0085
Onchocerca volvulus 0.0268 0.0773 0.0759
Echinococcus granulosus alpha 1A adrenergic receptor 0.0011 0.0015 0.0012
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0015 0.0015
Echinococcus multilocularis somatostatin receptor 0.0011 0.0015 0.0012
Echinococcus multilocularis serotonin transporter 0.0158 0.0448 0.0445
Schistosoma mansoni neuropeptide receptor 0.0011 0.0015 0.0015
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0158 0.0158
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0038 0.0095 0.0119
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0011 0.0015 0.0015
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0085 0.0082
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.003 0.1551
Brugia malayi hypothetical protein 0.0011 0.0015 0.0012
Trypanosoma cruzi C-8 sterol isomerase, putative 0.2628 0.7745 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0011 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.0671 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0036 0.0043
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0208 0.0205
Brugia malayi G protein-coupled receptor 0.0011 0.0015 0.0012
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.0015 0.0012

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 33.8078 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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