Detailed information for compound 1392991

Basic information

Technical information
  • TDR Targets ID: 1392991
  • Name: 5-(1,3-benzothiazol-2-ylmethylsulfanyl)-N-(2, 6-dimethylphenyl)-1,3,4-thiadiazol-2-amine
  • MW: 384.541 | Formula: C18H16N4S3
  • H donors: 1 H acceptors: 3 LogP: 5.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1Nc1nnc(s1)SCc1nc2c(s1)cccc2)C
  • InChi: 1S/C18H16N4S3/c1-11-6-5-7-12(2)16(11)20-17-21-22-18(25-17)23-10-15-19-13-8-3-4-9-14(13)24-15/h3-9H,10H2,1-2H3,(H,20,21)
  • InChiKey: RNEFBTWCZGFQEW-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 5-(1,3-benzothiazol-2-ylmethylthio)-N-(2,6-dimethylphenyl)-1,3,4-thiadiazol-2-amine
  • [5-(1,3-benzothiazol-2-ylmethylthio)-1,3,4-thiadiazol-2-yl]-(2,6-dimethylphenyl)amine
  • T0520-2016
  • MLS000389050
  • SMR000255224
  • ZINC03287089

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0014 0.0014
Schistosoma mansoni protein kinase 0.0138 0.0847 0.1595
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0196 0.0369
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0101 0.0607 0.0607
Entamoeba histolytica hypothetical protein 0.0133 0.0815 0.9621
Schistosoma mansoni cpg binding protein 0.0035 0.0182 0.0344
Onchocerca volvulus 0.006 0.0343 0.1843
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.0345 0.5578
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0038 0.0204 0.0204
Schistosoma mansoni hypothetical protein 0.0205 0.1274 0.2398
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0357 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0357 0.0391
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.0345 0.0345
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0097 0.151
Loa Loa (eye worm) hypothetical protein 0.0021 0.0097 0.0097
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0169 0.2769
Brugia malayi MAP kinase sur-1 0.006 0.0345 0.0345
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0325 0.373
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.0345 0.0377
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0144 0.0144
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0182 0.0182
Echinococcus granulosus cyclin dependent kinase 1 0.0101 0.0607 0.0664
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.1564 1 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0101 0.0607 0.7124
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.1431 0.9144 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0061 0.0066
Loa Loa (eye worm) hypothetical protein 0.0033 0.0173 0.0173
Giardia lamblia Kinase, CMGC GSK 0.0057 0.0325 0.1059
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.029 0.4773
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0144 0.2187
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0204 0.0385
Entamoeba histolytica protein kinase, putative 0.0138 0.0847 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0566 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0196 0.0369
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.029 0.0317
Toxoplasma gondii histone lysine methyltransferase SET1 0.0071 0.0418 0.6804
Giardia lamblia Kinase, CMGC MAPK 0.006 0.0345 0.1406
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.009 0.2376
Echinococcus granulosus PAK box P21 Rho binding 0.0133 0.0815 0.0892
Trichomonas vaginalis set domain proteins, putative 0.0287 0.1801 1
Trichomonas vaginalis STE family protein kinase 0.0138 0.0847 0.4673
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0566 0.9319
Brugia malayi P21-Rho-binding domain containing protein 0.0133 0.0815 0.0815
Echinococcus multilocularis cyclin dependent kinase 5 0.0101 0.0607 0.0664
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0057 0.0325 0.0355
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0057 0.0325 0.5236
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0183 0.02
Brugia malayi Kinase associated domain 1 family protein 0.0033 0.0173 0.0173
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0144 0.1558
Entamoeba histolytica protein kinase, putative 0.0138 0.0847 1
Entamoeba histolytica protein kinase, putative 0.0138 0.0847 1
Echinococcus multilocularis serine:threonine protein kinase 0.0049 0.0274 0.03
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0144 0.3914
Echinococcus multilocularis PAK box P21 Rho binding 0.0133 0.0815 0.0892
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0204 0.0385
Trypanosoma cruzi cdc2-related kinase 1 0.0101 0.0607 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0196 0.0369
Brugia malayi P21-Rho-binding domain containing protein 0.0133 0.0815 0.0815
Loa Loa (eye worm) hypothetical protein 0.0021 0.0097 0.0097
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0566 1
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0607 0.1144
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0607 0.3334
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0138 0.0847 0.0926
Plasmodium vivax protein kinase Crk2 0.0101 0.0607 1
Echinococcus granulosus cyclin dependent kinase 5 0.0101 0.0607 0.0664
Echinococcus multilocularis lamin 0.0033 0.0169 0.0185
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0101 0.0607 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.0169 0.0318
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0082 0.0487 0.0532
Loa Loa (eye worm) hypothetical protein 0.0016 0.0061 0.0061
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0082 0.0487 0.0532
Brugia malayi CXXC zinc finger family protein 0.0035 0.0182 0.0182
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0144 0.2351
Loa Loa (eye worm) hypothetical protein 0.0037 0.0196 0.0196
Trichomonas vaginalis STE family protein kinase 0.0138 0.0847 0.4673
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.029 0.1564
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0144 0.2351
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0014 0.0214
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0037 0.0037
Echinococcus granulosus lamin dm0 0.0033 0.0169 0.0185
Trypanosoma cruzi cdc2-related kinase 3 0.0101 0.0607 1
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0014 0.0014
Schistosoma mansoni tyrosine kinase 0.0133 0.0815 0.1536
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.531 1
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0072 0.0072
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0566 1
Trypanosoma cruzi cdc2-related kinase 1 0.0101 0.0607 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0014 0.0214
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.0345 0.0377
Brugia malayi Protein kinase domain 0.0138 0.0847 0.0847
Onchocerca volvulus 0.0037 0.0196 0.102
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0014 0.0014
Entamoeba histolytica cell division protein kinase 2, putative 0.0101 0.0607 0.7124
Brugia malayi cell division control protein 2 homolog 0.0101 0.0607 0.0607
Schistosoma mansoni lamin 0.0033 0.0169 0.0318
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0101 0.0607 0.0607
Plasmodium vivax glycogen synthase kinase 3, putative 0.0057 0.0325 0.5339
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.0815 0.1536
Toxoplasma gondii hypothetical protein 0.0033 0.0169 0.261
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0144 0.2187
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.0345 0.5578
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0133 0.0815 0.0892
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0024 0.0026
Echinococcus granulosus geminin 0.0205 0.1274 0.1393
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0196 0.0369
Brugia malayi intermediate filament protein 0.0033 0.0169 0.0169
Echinococcus granulosus serine:threonine protein kinase 0.0049 0.0274 0.03
Schistosoma mansoni hypothetical protein 0.0033 0.0173 0.0325
Entamoeba histolytica hypothetical protein 0.0133 0.0815 0.9621
Schistosoma mansoni hypothetical protein 0.0494 0.3131 0.5896
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.029 0.4658
Loa Loa (eye worm) hypothetical protein 0.0033 0.0169 0.0169
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0014 0.002
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0049 0.0274 0.0274
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0169 0.261
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0057 0.0325 0.0611
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0014 0.0014
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.3131 0.3424
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0345 0.1869
Trypanosoma brucei cdc2-related kinase 1 0.0101 0.0607 1
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0097 0.1405
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0325 0.373
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0014 0.0214
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0014 0.0214
Loa Loa (eye worm) hypothetical protein 0.0133 0.0815 0.0815
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0345 0.1869
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0345 0.065
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0325 0.1755
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.531 0.5807
Echinococcus multilocularis lamin dm0 0.0033 0.0169 0.0185
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0169 0.0169
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0036 0.0036
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0566 0.0619
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0014 0.0014
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0343 0.0646
Echinococcus multilocularis musashi 0.0033 0.0169 0.0185
Schistosoma mansoni protein kinase 0.0133 0.0815 0.1536
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1083 0.204
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0607 0.3334
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0101 0.0607 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.0133 0.0815 0.1536
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0057 0.0325 0.5236
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.0169 0.2805
Schistosoma mansoni hypothetical protein 0.0133 0.0815 0.1536
Brugia malayi Pre-SET motif family protein 0.0037 0.0196 0.0196
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0566 0.0619
Trichomonas vaginalis STE family protein kinase 0.0138 0.0847 0.4673
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.009 0.2376
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0138 0.0847 0.0926
Echinococcus granulosus dnaJ subfamily B 0.0494 0.3131 0.3424
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0144 0.1558
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.1578 0.1578
Loa Loa (eye worm) hypothetical protein 0.006 0.0343 0.0343
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0133 0.0815 0.0892
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0357 1
Schistosoma mansoni cpg binding protein 0.0037 0.0195 0.0367
Loa Loa (eye worm) hypothetical protein 0.0094 0.0566 0.0566
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0072 0.0072
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0325 0.1755
Onchocerca volvulus 0.0029 0.0144 0.0726
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0566 0.9304
Loa Loa (eye worm) hypothetical protein 0.0021 0.0097 0.0097
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0345 0.1869
Echinococcus multilocularis cpg binding protein 0.0037 0.0195 0.0213
Echinococcus multilocularis cyclin dependent kinase 1 0.0101 0.0607 0.0664
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0057
Echinococcus granulosus intermediate filament protein 0.0033 0.0169 0.0185
Brugia malayi Protein kinase domain containing protein 0.0101 0.0607 0.0607
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0169 0.0169
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0057 0.0325 0.0355
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0566 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0014 0.0214
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0037 0.0041
Echinococcus granulosus lamin 0.0033 0.0169 0.0185
Entamoeba histolytica protein kinase, putative 0.0057 0.0325 0.373
Echinococcus granulosus tumor protein p63 0.0408 0.2579 0.2821
Echinococcus multilocularis cyclin dependent kinase 1 0.0101 0.0607 0.0664
Loa Loa (eye worm) acetyltransferase 0.0175 0.1083 0.1083
Echinococcus granulosus cyclin dependent kinase 0.0101 0.0607 0.0664
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0196 0.3072
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.009 0.2376
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0057 0.0325 0.5236
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0133 0.0815 0.0815
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0144 0.0144
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0325 0.0325
Onchocerca volvulus 0.0057 0.0325 0.1739
Loa Loa (eye worm) hypothetical protein 0.0029 0.0144 0.0144
Entamoeba histolytica protein kinase, putative 0.0138 0.0847 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0014
Echinococcus multilocularis protein kinase shaggy 0.0057 0.0325 0.0355
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0566 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0057
Echinococcus multilocularis cyclin dependent kinase 0.0101 0.0607 0.0664
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0144 0.2351
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0101 0.0607 1
Echinococcus granulosus mitogen activated protein kinase 0.006 0.0345 0.0377
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0487 0.0917
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0014 0.0015
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0014 0.0014
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0144 0.1558
Trypanosoma cruzi cdc2-related kinase 3 0.0101 0.0607 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0014
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0138 0.0847 0.0926
Brugia malayi Protein kinase domain containing protein 0.0049 0.0274 0.0274
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0274 0.1472
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0133 0.0815 0.0892
Entamoeba histolytica p21-activated kinase 0.0138 0.0847 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0144 0.2351
Trichomonas vaginalis STE family protein kinase 0.0138 0.0847 0.4673
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0138 0.0847 0.0926
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0101 0.0607 0.0664
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0024 0.0026
Echinococcus multilocularis serine:threonine protein kinase 0.0049 0.0274 0.03
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0566 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0566 0.5
Schistosoma mansoni hypothetical protein 0.0205 0.1274 0.2398
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0014 0.0015
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0144 0.2351
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.1431 0.9144 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.0345 0.5578
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0014 0.002
Echinococcus granulosus microtubule associated protein 2 0.0833 0.531 0.5807
Schistosoma mansoni lamin 0.0033 0.0169 0.0318
Loa Loa (eye worm) hypothetical protein 0.0021 0.0097 0.0097
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0345 0.5578
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0263 0.2988
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1083 0.1083
Schistosoma mansoni cpg binding protein 0.0037 0.0195 0.0367
Brugia malayi Pre-SET motif family protein 0.0252 0.1578 0.1578
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0082 0.0487 0.0532
Plasmodium vivax SET domain protein, putative 0.0037 0.0196 0.3221
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0037 0.0041
Trypanosoma brucei protein kinase, putative 0.0057 0.0325 0.5236
Echinococcus multilocularis hypothetical protein 0.0033 0.0173 0.0189
Schistosoma mansoni hypothetical protein 0.0133 0.0815 0.1536
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0014 0.0214
Plasmodium falciparum protein kinase 5 0.0101 0.0607 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0144 0.2187
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0138 0.0847 0.0926
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0101 0.0607 0.0607
Loa Loa (eye worm) hypothetical protein 0.0032 0.0165 0.0165
Giardia lamblia Kinase, CMGC GSK 0.0057 0.0325 0.1059
Loa Loa (eye worm) hypothetical protein 0.0049 0.0274 0.0274
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0204 0.1083
Onchocerca volvulus 0.0035 0.0182 0.0944
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0487 0.0917
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0014 0.0215
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0263 0.4194
Echinococcus multilocularis geminin 0.0205 0.1274 0.1393
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0133 0.0815 0.1536
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0014
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0196 0.0214
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0357 0.0391
Brugia malayi intracellular kinase 0.0057 0.0325 0.0325
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0607 0.1144
Trichomonas vaginalis STE family protein kinase 0.0138 0.0847 0.4673
Schistosoma mansoni hypothetical protein 0.0033 0.0173 0.0325
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.009 0.2376
Onchocerca volvulus 0.0033 0.0169 0.0868
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0196 0.0214
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0014 0.0214
Echinococcus multilocularis PAK box P21 Rho binding 0.0138 0.0847 0.0926
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0441 0.083
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0204 0.0385
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0144 0.2351
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0144 0.3914
Echinococcus multilocularis calcium activated potassium channel 0.0038 0.0204 0.0223
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0144 0.2351
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0014 0.0014
Mycobacterium ulcerans hypothetical protein 0.0029 0.0144 0.2351
Schistosoma mansoni protein kinase 0.0138 0.0847 0.1595
Loa Loa (eye worm) hypothetical protein 0.0021 0.0097 0.0097
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0024 0.0026
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0061 0.0066
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0097 0.2589
Schistosoma mansoni serine/threonine kinase 0.0038 0.0204 0.0385
Trypanosoma brucei cdc2-related kinase 3 0.0101 0.0607 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0566 0.1066
Brugia malayi Protein kinase domain containing protein 0.0038 0.0204 0.0204
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0024 0.0044
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0566 0.9304
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0014 0.0214
Trypanosoma brucei protein kinase, putative 0.006 0.0345 0.5578
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0138 0.0847 0.0926
Plasmodium falciparum glycogen synthase kinase 3 0.0057 0.0325 0.5236
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0014 0.0214
Loa Loa (eye worm) hypothetical protein 0.0096 0.0576 0.0576
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6247 0.6831
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0014 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0144 0.2351
Schistosoma mansoni protein kinase 0.0138 0.0847 0.1595
Giardia lamblia Kinase, CMGC CDK 0.0101 0.0607 0.5898
Brugia malayi WH1 domain containing protein 0.0133 0.0815 0.0815
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0196 0.0214
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0345 0.1869
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.0345 0.5578
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1083 0.1185
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0014 0.0214
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0024 0.0026
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.0345 0.5578
Loa Loa (eye worm) hypothetical protein 0.0029 0.0144 0.0144
Echinococcus granulosus cpg binding protein 0.0037 0.0195 0.0213
Echinococcus multilocularis tumor protein p63 0.0408 0.2579 0.2821
Giardia lamblia Kinase, CMGC CDK 0.0101 0.0607 0.5898
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1052 0.115
Onchocerca volvulus 0.0033 0.0169 0.0868
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0357 0.6218
Loa Loa (eye worm) hypothetical protein 0.0029 0.0144 0.0144
Giardia lamblia Kinase, STE STE20 0.0138 0.0847 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0566 0.9304
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.0815 0.4496
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.0345 0.0377
Onchocerca volvulus 0.0287 0.1801 1
Brugia malayi Probable ClpP-like protease 0.0094 0.0566 0.0566
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0607 0.3334
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0169 0.0169
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.0345 0.5578
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.029 0.4658
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0014 0.0214
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.029 0.1564
Echinococcus granulosus calcium activated potassium channel 0.0038 0.0204 0.0223
Echinococcus granulosus serine:threonine protein kinase 0.0049 0.0274 0.03
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0144 0.2351
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0097 0.159
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0345 0.5578
Echinococcus granulosus protein kinase shaggy 0.0057 0.0325 0.0355
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.0014
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0325 0.0325
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0082 0.0487 0.0532

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.4716 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 4.1095 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.012 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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