Detailed information for compound 1401446

Basic information

Technical information
  • TDR Targets ID: 1401446
  • Name: 3-(1,3-benzodioxol-5-yl)-1-[(3-fluorophenyl)m ethyl]pyrazole
  • MW: 296.296 | Formula: C17H13FN2O2
  • H donors: 0 H acceptors: 1 LogP: 3.4 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)Cn1ccc(n1)c1ccc2c(c1)OCO2
  • InChi: 1S/C17H13FN2O2/c18-14-3-1-2-12(8-14)10-20-7-6-15(19-20)13-4-5-16-17(9-13)22-11-21-16/h1-9H,10-11H2
  • InChiKey: QMQFMDFYNGFSMN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(1,3-benzodioxol-5-yl)-1-(3-fluorobenzyl)pyrazole
  • ZINC01394868
  • 3-(1,3-benzodioxol-5-yl)-1-(3-fluorobenzyl)-1H-pyrazole
  • MLS000547349
  • SMR000180248
  • 6T-0214

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis pdz domain containing protein 0.0033 0.0031 0.0037
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0043 0.0072 0.4019
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0033 0.0031 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0085 0.0364
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0033 0.0031 0.0037
Trypanosoma cruzi hypothetical protein 0.0033 0.0031 0.1706
Echinococcus multilocularis myotubularin protein 13 0.0033 0.0031 0.0037
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0043 0.0072 0.4019
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0046 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0046 0.0088 0.0085
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0033 0.0031 0.0202
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0043 0.0072 0.4019
Entamoeba histolytica hypothetical protein 0.0033 0.0031 0.0202
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0046 0.0043
Brugia malayi hypothetical protein 0.0365 0.1521 0.1518
Entamoeba histolytica PH domain containing protein kinase, putative 0.0043 0.0072 0.0475
Schistosoma mansoni rho gtpase activating protein 0.0033 0.0031 0.0031
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0043 0.0072 0.4019
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0067 0.018 1
Brugia malayi hypothetical protein 0.0365 0.1521 0.1518
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0033 0.0031 0.0295
Brugia malayi PH domain containing protein 0.0033 0.0031 0.0028
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0046 0.0055
Brugia malayi Sema domain containing protein 0.0104 0.0348 0.0345
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0224 0.0221
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0033 0.0031 0.1706
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0365 0.1521 0.1518
Leishmania major hypothetical protein, conserved 0.0033 0.0031 0.1706
Schistosoma mansoni hypothetical protein 0.0046 0.0085 0.0085
Onchocerca volvulus 0.0104 0.0348 0.3674
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0033 0.0031 0.0037
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0033 0.0031 0.1706
Brugia malayi PH domain containing protein 0.0033 0.0031 0.0028
Loa Loa (eye worm) hypothetical protein 0.006 0.0149 0.0146
Loa Loa (eye worm) oxysterol binding protein 0.0033 0.0031 0.0028
Trypanosoma brucei PH domain containing protein, putative 0.0033 0.0031 0.1706
Onchocerca volvulus 0.0033 0.0031 0.0295
Echinococcus multilocularis beta 1 syntrophin 0.0033 0.0031 0.0037
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1884 0.8359 0.8359
Brugia malayi Syntrophin-1 0.0033 0.0031 0.0028
Brugia malayi PXA domain containing protein 0.0365 0.1521 0.1518
Trypanosoma cruzi PH domain containing protein, putative 0.0033 0.0031 0.1706
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0033 0.0031 0.0028
Echinococcus granulosus Oxysterol binding protein 11 0.0033 0.0031 0.0037
Echinococcus granulosus MAM 0.0027 0.0003 0.0004
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0033 0.0031 0.1706
Echinococcus multilocularis Immunoglobulin 0.0046 0.0088 0.0105
Loa Loa (eye worm) hypothetical protein 0.0365 0.1521 0.1518
Echinococcus multilocularis cytohesin 1 0.0033 0.0031 0.0037
Echinococcus multilocularis Pleckstrin y 0.0033 0.0031 0.0037
Schistosoma mansoni plexin 0.0132 0.0474 0.0474
Trypanosoma cruzi hypothetical protein 0.0033 0.0031 0.1706
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0033 0.0031 0.0028
Brugia malayi PH domain containing protein 0.0033 0.0031 0.0028
Entamoeba histolytica protein kinase, putative 0.0067 0.018 0.1183
Echinococcus granulosus aurora kinase A 0.0067 0.018 0.0215
Brugia malayi MAX-1A 0.0033 0.0031 0.0028
Brugia malayi PH domain containing protein 0.0033 0.0031 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0085 0.0364
Trypanosoma cruzi PH domain containing protein, putative 0.0033 0.0031 0.1706
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0064 0.0166 0.0163
Onchocerca volvulus 0.0033 0.0031 0.0295
Trypanosoma brucei rac serine-threonine kinase, putative 0.0043 0.0072 0.4019
Schistosoma mansoni myotubularin-related protein 0.0033 0.0031 0.0031
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0062 0.0062
Schistosoma mansoni goodpasture antigen-binding protein 0.0033 0.0031 0.0031
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0033 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Echinococcus multilocularis pleckstrin y domain containing family A 0.0033 0.0031 0.0037
Brugia malayi A-kinase anchor protein 10, precursor 0.0365 0.1521 0.1518
Echinococcus granulosus tar DNA binding protein 0.0076 0.0224 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0365 0.1521 1
Echinococcus multilocularis expressed protein 0.0365 0.1521 0.1819
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0365 0.1521 0.1819
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0067 0.018 0.0215
Schistosoma mansoni goodpasture antigen-binding protein 0.0033 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Echinococcus multilocularis G protein coupled receptor kinase 1 0.1359 0.5997 0.7174
Loa Loa (eye worm) Plekhf2 protein 0.0033 0.0031 0.0028
Schistosoma mansoni hypothetical protein 0.0104 0.0348 0.0348
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0043 0.0072 0.4019
Entamoeba histolytica protein kinase , putative 0.0067 0.018 0.1183
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0033 0.0031 0.0202
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0224 0.0221
Brugia malayi Protein kinase domain containing protein 0.0245 0.0984 0.0982
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.4286 0.5128
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Loa Loa (eye worm) AUR protein kinase 0.0067 0.018 0.0177
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0033 0.0031 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0085 0.0364
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0033 0.0031 0.0028
Echinococcus granulosus oxysterol binding protein 9 0.0033 0.0031 0.0037
Trypanosoma cruzi hypothetical protein 0.0033 0.0031 0.1706
Schistosoma mansoni hypothetical protein 0.0033 0.0031 0.0031
Brugia malayi PH domain containing protein 0.0033 0.0031 0.0028
Loa Loa (eye worm) hypothetical protein 0.0046 0.0088 0.0085
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0033 0.0031 0.0037
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0046 0.0088 0.0088
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Brugia malayi probable spectrin beta chain 0.0033 0.0031 0.0028
Loa Loa (eye worm) hypothetical protein 0.0046 0.0088 0.0085
Schistosoma mansoni hypothetical protein 0.0033 0.0031 0.0031
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0033 0.0031 0.0028
Toxoplasma gondii phosphatidylinositol transfer protein 0.0033 0.0031 0.1706
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0046 0.0085 0.0364
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0224 0.0268
Onchocerca volvulus Putative zinc finger protein 0.0033 0.0031 0.0295
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Brugia malayi Immunoglobulin I-set domain containing protein 0.0064 0.0166 0.0163
Echinococcus granulosus defective proboscis extension response 0.0046 0.0088 0.0105
Echinococcus multilocularis calcium dependent secretion activator 1 0.0033 0.0031 0.0037
Brugia malayi IPT/TIG domain containing protein 0.0046 0.0085 0.0082
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0033 0.0031 0.0202
Schistosoma mansoni serine/threonine-protein kinase 0.0043 0.0072 0.0072
Loa Loa (eye worm) rho-GTPase-activating 0.0033 0.0031 0.0028
Schistosoma mansoni axis inhibition protein axin 0.0365 0.1521 0.1521
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0088 0.0085
Brugia malayi Uncoordinated protein 104 0.0033 0.0031 0.0028
Onchocerca volvulus 0.006 0.0149 0.1555
Schistosoma mansoni hypothetical protein 0.0132 0.0474 0.0474
Echinococcus granulosus dynamin 1 0.0033 0.0031 0.0037
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0033 0.0031 0.0202
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0043 0.0072 0.4019
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0033 0.0031 0.0028
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0224 0.0224
Schistosoma mansoni zinc finger protein 0.0033 0.0031 0.0031
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0033 0.0031 0.0037
Echinococcus granulosus GRB2 associated binding protein 3 0.0033 0.0031 0.0037
Loa Loa (eye worm) AUR protein kinase 0.0067 0.018 0.0177
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0033 0.0031 0.0295
Entamoeba histolytica tyrosin kinase, putative 0.0063 0.0163 0.1073
Loa Loa (eye worm) hypothetical protein 0.0132 0.0474 0.0471
Echinococcus granulosus Pleckstrin y 0.0033 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0046 0.0085 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0365 0.1521 1
Entamoeba histolytica PH domain containing protein 0.0033 0.0031 0.0202
Echinococcus granulosus neuroglian 0.0046 0.0088 0.0105
Schistosoma mansoni syntrophin 0.0033 0.0031 0.0031
Echinococcus granulosus beta 1 syntrophin 0.0033 0.0031 0.0037
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0365 0.1521 0.1521
Trypanosoma brucei protein kinase, putative 0.0043 0.0072 0.4019
Echinococcus granulosus semaphorin 5B 0.0104 0.0348 0.0416
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0033 0.0031 0.0037
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0033 0.0031 0.0202
Echinococcus multilocularis DCC interacting protein 13 beta 0.0033 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0104 0.0348 0.0345
Schistosoma mansoni hypothetical protein 0.0033 0.0031 0.0031
Echinococcus multilocularis axis inhibition protein axin 0.0365 0.1521 0.1819
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0046 0.0055
Loa Loa (eye worm) hypothetical protein 0.0046 0.0088 0.0085
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0224 0.0224
Schistosoma mansoni regulator of G protein signaling 0.0365 0.1521 0.1521
Echinococcus multilocularis axis inhibition protein axin 0.0365 0.1521 0.1819
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0043 0.0072 0.0279
Loa Loa (eye worm) hypothetical protein 0.0104 0.0348 0.0345
Schistosoma mansoni regulator of G protein signaling 0.0365 0.1521 0.1521
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.1884 0.8359 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Plasmodium falciparum PH domain-containing protein, putative 0.0033 0.0031 0.1706
Leishmania major hypothetical protein, conserved 0.0033 0.0031 0.1706
Trichomonas vaginalis AGC family protein kinase 0.0067 0.018 0.1001
Entamoeba histolytica PH domain containing protein kinase, putative 0.0043 0.0072 0.0475
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1884 0.8359 0.8359
Brugia malayi PH domain containing protein 0.0033 0.0031 0.0028
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0046 0.0088 0.0105
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0033 0.0031 0.0202
Echinococcus granulosus Regulator of G protein signaling 20 0.0365 0.1521 0.1819
Entamoeba histolytica hypothetical protein 0.0046 0.0085 0.0559
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0067 0.018 0.0215
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0043 0.0072 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0085 0.0364
Onchocerca volvulus outspread protein homolog 0.0033 0.0031 0.0295
Entamoeba histolytica protein kinase domain containing protein 0.0067 0.018 0.1183
Entamoeba histolytica hypothetical protein 0.0033 0.0031 0.0202
Echinococcus granulosus tumor protein p63 0.0408 0.1716 0.2053
Loa Loa (eye worm) PH domain-containing protein 0.0033 0.0031 0.0028
Entamoeba histolytica hypothetical protein 0.0033 0.0031 0.0202
Toxoplasma gondii Oxysterol-binding protein 0.0033 0.0031 0.1706
Entamoeba histolytica hypothetical protein 0.0365 0.1521 1
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0043 0.0072 0.4019
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0046 0.0085 0.0364
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0043 0.0072 0.4019
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0365 0.1521 0.1819
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0033 0.0031 0.0202
Echinococcus multilocularis Regulator of G protein signaling 20 0.0365 0.1521 0.1819
Loa Loa (eye worm) hypothetical protein 0.0104 0.0348 0.0345
Brugia malayi Dynamin 0.0033 0.0031 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Echinococcus multilocularis Ras associated and pleckstrin y 0.0033 0.0031 0.0037
Entamoeba histolytica hypothetical protein 0.0046 0.0085 0.0559
Echinococcus granulosus myotubularin protein 13 0.0033 0.0031 0.0037
Brugia malayi DNA-binding protein LAG-1 0.0046 0.0085 0.0082
Loa Loa (eye worm) syntrophin-1 0.0033 0.0031 0.0028
Echinococcus multilocularis oxysterol binding protein 1 0.0033 0.0031 0.0037
Echinococcus granulosus DCC interacting protein 13 beta 0.0033 0.0031 0.0037
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0046 0.0088 0.0105
Plasmodium falciparum calcium-dependent protein kinase 7 0.0043 0.0072 0.4019
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Brugia malayi Pleckstrin Homology Domain 0.0033 0.0031 0.0028
Schistosoma mansoni regulator of G protein signaling 0.0365 0.1521 0.1521
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0046 0.0085 0.0364
Loa Loa (eye worm) PXA domain-containing protein 0.0365 0.1521 0.1518
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0043 0.0072 0.4019
Brugia malayi RNA binding protein 0.0076 0.0224 0.0221
Echinococcus multilocularis Pleckstrin y 0.0033 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Schistosoma mansoni zinc finger protein 0.0033 0.0031 0.0031
Entamoeba histolytica hypothetical protein 0.0033 0.0031 0.0202
Onchocerca volvulus 0.0033 0.0031 0.0295
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0033 0.0031 0.0031
Brugia malayi TBC domain containing protein 0.0033 0.0031 0.0028
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0031 0.0202
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0033 0.0031 0.0028
Echinococcus granulosus semaphorin 1A 0.0104 0.0348 0.0416
Echinococcus granulosus twitchin 0.0055 0.013 0.0155
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0033 0.0031 0.0202
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0067 0.018 0.1183
Schistosoma mansoni nephrin 0.0046 0.0088 0.0088
Schistosoma mansoni growth factor receptor-bound protein 0.0033 0.0031 0.0031
Entamoeba histolytica protein kinase, putative 0.0043 0.0072 0.0475
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Trypanosoma cruzi NIMA-related kinase, putative 0.0043 0.0072 0.4019
Toxoplasma gondii hypothetical protein 0.0033 0.0031 0.1706
Brugia malayi Plekhf2 protein 0.0033 0.0031 0.0028
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0043 0.0072 0.4019
Echinococcus multilocularis Oxysterol binding protein 11 0.0033 0.0031 0.0037
Echinococcus multilocularis regulator of G protein signaling 7 0.0365 0.1521 0.1819
Echinococcus multilocularis regulator of G protein signaling 3 0.0365 0.1521 0.1819
Trichomonas vaginalis AGC family protein kinase 0.0067 0.018 0.1001
Schistosoma mansoni vav2 0.0033 0.0031 0.0031
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0033 0.0031 0.0037
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0033 0.0031 0.1706
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Schistosoma mansoni cell adhesion molecule 0.0046 0.0088 0.0088
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0033 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0104 0.0348 0.0345
Toxoplasma gondii AtPH1 family protein 0.0033 0.0031 0.1706
Loa Loa (eye worm) plexin A 0.0281 0.1146 0.1143
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0033 0.0031 0.0037
Entamoeba histolytica PH domain containing protein 0.0033 0.0031 0.0202
Entamoeba histolytica hypothetical protein 0.0033 0.0031 0.0202
Schistosoma mansoni serine/threonine protein kinase 0.1724 0.7637 0.7637
Leishmania major protein kinase, putative 0.0043 0.0072 0.4019
Echinococcus multilocularis actin binding protein anillin 0.0033 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0033 0.0031 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0365 0.1521 1
Echinococcus multilocularis oxysterol binding protein 9 0.0033 0.0031 0.0037
Loa Loa (eye worm) sema domain-containing protein 0.0104 0.0348 0.0345
Onchocerca volvulus 0.0033 0.0031 0.0295
Trypanosoma cruzi hypothetical protein 0.0033 0.0031 0.1706
Echinococcus multilocularis neuroglian 0.0046 0.0088 0.0105
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0033 0.0031 0.1706
Brugia malayi serine/threonine-protein kinase 6 0.0067 0.018 0.0177
Echinococcus granulosus regulator of G protein signaling 7 0.0365 0.1521 0.1819
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0033 0.0031 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0085 0.0364
Brugia malayi Oxysterol-binding protein 0.0033 0.0031 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0365 0.1521 1
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Loa Loa (eye worm) hypothetical protein 0.0365 0.1521 0.1518
Schistosoma mansoni dynamin 0.0033 0.0031 0.0031
Onchocerca volvulus 0.0236 0.0941 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.0043 0.0072 0.0069
Plasmodium falciparum oxysterol-binding protein, putative 0.0033 0.0031 0.1706
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0046 0.0085 0.0364
Schistosoma mansoni z-protein (S1r protein) 0.0365 0.1521 0.1521
Echinococcus multilocularis transcription factor collier 0.0046 0.0085 0.0102
Echinococcus granulosus expressed protein 0.0365 0.1521 0.1819
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0046 0.0043
Toxoplasma gondii aurora kinase 0.0067 0.018 1
Leishmania major serine/threonine-protein kinase a, putative 0.0043 0.0072 0.4019
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Loa Loa (eye worm) uncoordinated protein 104 0.0033 0.0031 0.0028
Echinococcus granulosus pdz domain containing protein 0.0033 0.0031 0.0037
Schistosoma mansoni dynamin 0.0033 0.0031 0.0031
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Echinococcus granulosus Immunoglobulin 0.0046 0.0088 0.0105
Loa Loa (eye worm) hypothetical protein 0.0046 0.0088 0.0085
Echinococcus multilocularis GRB2 associated binding protein 3 0.0033 0.0031 0.0037
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.1724 0.7637 0.7637
Entamoeba histolytica cell surface protease gp63, putative 0.0046 0.0085 0.0559
Entamoeba histolytica PH domain containing protein kinase, putative 0.0043 0.0072 0.0475
Echinococcus granulosus Rho GTPase activating protein 24 0.0033 0.0031 0.0037
Entamoeba histolytica hypothetical protein 0.0365 0.1521 1
Toxoplasma gondii protein kinase domain-containing protein 0.0043 0.0072 0.4019
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0035 0.0031
Echinococcus multilocularis Rho GTPase activating protein 24 0.0033 0.0031 0.0037
Leishmania major protein kinase, putative 0.0043 0.0072 0.4019
Schistosoma mansoni vesicular amine transporter 0.0049 0.0099 0.0099
Echinococcus granulosus beta-adrenergic receptor kinase 0.1724 0.7637 0.9136
Trypanosoma brucei aurora B kinase 0.0067 0.018 1
Brugia malayi Sema domain containing protein 0.0104 0.0348 0.0345
Brugia malayi Oxysterol binding protein 0.0033 0.0031 0.0028
Echinococcus multilocularis oxysterol binding protein 3 0.0033 0.0031 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.1724 0.7637 0.7637
Entamoeba histolytica p21-activated kinase 0.0043 0.0072 0.0475
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0046 0.0085 0.0364
Echinococcus multilocularis aurora kinase A 0.0067 0.018 0.0215
Loa Loa (eye worm) hypothetical protein 0.0365 0.1521 0.1518
Brugia malayi serine/threonine kinase 12 0.0067 0.018 0.0177
Brugia malayi PXA domain containing protein 0.0365 0.1521 0.1518
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Entamoeba histolytica protein kinase, putative 0.0067 0.018 0.1183
Brugia malayi Variant SH3 domain containing protein 0.0033 0.0031 0.0028
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0365 0.1521 1
Brugia malayi TAR-binding protein 0.0076 0.0224 0.0221
Trypanosoma cruzi NIMA-related kinase, putative 0.0043 0.0072 0.4019
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Entamoeba histolytica protein kinase, putative 0.0043 0.0072 0.0475
Schistosoma mansoni semaphorin 5-related 0.0104 0.0348 0.0348
Echinococcus granulosus Pleckstrin y 0.0033 0.0031 0.0037
Brugia malayi hypothetical protein 0.0046 0.0088 0.0085
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0033 0.0031 0.0037
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0043 0.0072 0.4019
Echinococcus granulosus exocyst complex component 2 0.0046 0.0085 0.0102
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Leishmania major folate/biopterin transporter, putative 0.0043 0.0072 0.4019
Entamoeba histolytica hypothetical protein 0.0365 0.1521 1
Loa Loa (eye worm) sema domain-containing protein 0.0104 0.0348 0.0345
Brugia malayi hypothetical protein 0.0033 0.0031 0.0028
Schistosoma mansoni regulator of G protein signaling 0.0365 0.1521 0.1521
Brugia malayi Plexin repeat family protein 0.0236 0.0941 0.0938
Trypanosoma cruzi PH domain containing protein, putative 0.0033 0.0031 0.1706
Schistosoma mansoni serine/threonine-protein kinase 0.0043 0.0072 0.0072
Echinococcus multilocularis beta adrenergic receptor kinase 0.1724 0.7637 0.9136
Brugia malayi PH domain containing protein 0.0033 0.0031 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Echinococcus multilocularis regulator of G protein signaling 3 0.0365 0.1521 0.1819
Echinococcus multilocularis regulator of G protein signaling 0.0365 0.1521 0.1819
Loa Loa (eye worm) hypothetical protein 0.0046 0.0088 0.0085
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0033 0.0031 0.0031
Brugia malayi Variant SH3 domain containing protein 0.0033 0.0031 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0365 0.1521 1
Trichomonas vaginalis AGC family protein kinase 0.0067 0.018 0.1001
Brugia malayi regulator of G-protein signaling rgs-7 0.0365 0.1521 0.1518
Echinococcus multilocularis MAM 0.0027 0.0003 0.0004
Entamoeba histolytica protein kinase domain containing protein 0.0063 0.0163 0.1073
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0043 0.0072 0.2788
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0149 0.0149
Schistosoma mansoni hypothetical protein 0.0027 0.0003 0.0003
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0043 0.0072 0.4019
Loa Loa (eye worm) RNA binding protein 0.0076 0.0224 0.0221
Echinococcus granulosus calcium dependent secretion activator 1 0.0033 0.0031 0.0037
Echinococcus multilocularis plexin a4 0.0281 0.1146 0.1371
Brugia malayi Probable exocyst complex component Sec5 0.0046 0.0085 0.0082
Brugia malayi Cadps2 protein 0.0033 0.0031 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.018 0.018
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0033 0.0031 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0224 0.0224
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0033 0.0031 0.0202
Schistosoma mansoni oxysterol-binding protein 1 0.0033 0.0031 0.0031
Entamoeba histolytica protein kinase, putative 0.0043 0.0072 0.0475
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0046 0.0088 0.0085
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0224 0.0224
Brugia malayi PH domain containing protein 0.0033 0.0031 0.0028
Onchocerca volvulus 0.0033 0.0031 0.0295
Entamoeba histolytica PH domain containing protein kinase, putative 0.0043 0.0072 0.0475
Loa Loa (eye worm) hypothetical protein 0.0365 0.1521 0.1518
Entamoeba histolytica PH domain containing protein kinase, putative 0.0043 0.0072 0.0475
Entamoeba histolytica PH domain containing protein 0.0033 0.0031 0.0202
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Echinococcus multilocularis regulator of G protein signaling 7 0.0365 0.1521 0.1819
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0085 0.0364
Loa Loa (eye worm) hypothetical protein 0.0236 0.0941 0.0938
Brugia malayi hypothetical protein 0.0104 0.0348 0.0345
Echinococcus granulosus G protein coupled receptor kinase 1 0.1359 0.5997 0.7174
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0085 0.0364
Echinococcus granulosus regulator of G protein signaling 7 0.0365 0.1521 0.1819
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0043 0.0072 0.4019
Entamoeba histolytica hypothetical protein 0.0046 0.0085 0.0559
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0033 0.0031 0.0028
Schistosoma mansoni hypothetical protein 0.0046 0.0085 0.0085
Schistosoma mansoni centaurin alpha 0.0033 0.0031 0.0031
Schistosoma mansoni axis inhibition protein axin 0.0365 0.1521 0.1521
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Entamoeba histolytica protein kinase, putative 0.0043 0.0072 0.0475
Brugia malayi Cytohesin 3 0.0033 0.0031 0.0028
Echinococcus granulosus axis inhibition protein axin 0.0365 0.1521 0.1819
Brugia malayi PH domain containing protein 0.0033 0.0031 0.0028
Schistosoma mansoni plexin 0.0236 0.0941 0.0941
Schistosoma mansoni regulator of G protein signaling 0.0365 0.1521 0.1521
Echinococcus multilocularis roundabout 2 0.0046 0.0088 0.0105
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0067 0.018 0.1183
Brugia malayi serine/threonine protein kinase 6 0.0067 0.018 0.0177
Trypanosoma cruzi PH domain containing protein, putative 0.0033 0.0031 0.1706
Giardia lamblia Aurora kinase 0.0067 0.018 0.5
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0033 0.0031 0.0037
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0033 0.0031 0.0202
Brugia malayi Dynamin 0.0033 0.0031 0.0028
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0033 0.0031 0.0037
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0067 0.018 0.1183
Echinococcus multilocularis exocyst complex component 2 0.0046 0.0085 0.0102
Trypanosoma cruzi Protein kinase B 0.0043 0.0072 0.4019
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Entamoeba histolytica protein kinase, putative 0.0043 0.0072 0.0475
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0033 0.0031 0.0031
Echinococcus granulosus oxysterol binding protein 3 0.0033 0.0031 0.0037
Trypanosoma cruzi hypothetical protein 0.0033 0.0031 0.1706
Leishmania major protein kinase, putative 0.0067 0.018 1
Schistosoma mansoni protein kinase 0.0067 0.018 0.018
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0033 0.0031 0.0037
Echinococcus granulosus serine/threonine protein kinase 0.0043 0.0072 0.0086
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0033 0.0031 0.0202
Plasmodium falciparum serine/threonine protein kinase, putative 0.0067 0.018 1
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0033 0.0031 0.0037
Echinococcus multilocularis G protein coupled receptor kinase 6 0.1884 0.8359 1
Toxoplasma gondii hypothetical protein 0.0033 0.0031 0.1706
Echinococcus multilocularis Pleckstrin y 0.0033 0.0031 0.0037
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Loa Loa (eye worm) hypothetical protein 0.0032 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0201 0.0783 0.078
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.1884 0.8359 0.8359
Brugia malayi plexin A 0.0281 0.1146 0.1143
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0043 0.0072 0.4019
Loa Loa (eye worm) hypothetical protein 0.0046 0.0088 0.0085
Echinococcus granulosus roundabout 2 0.0046 0.0088 0.0105
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0033 0.0031 0.0202
Trypanosoma cruzi hypothetical protein 0.0033 0.0031 0.1706
Entamoeba histolytica protein kinase, putative 0.0043 0.0072 0.0475
Trypanosoma cruzi aurora B kinase, putative 0.0067 0.018 1
Trichomonas vaginalis AGC family protein kinase 0.0067 0.018 0.1001
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Schistosoma mansoni hypothetical protein 0.0033 0.0031 0.0031
Entamoeba histolytica hypothetical protein 0.0046 0.0085 0.0559
Entamoeba histolytica hypothetical protein 0.0043 0.0072 0.0475
Trypanosoma cruzi hypothetical protein 0.0033 0.0031 0.1706
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0365 0.1521 0.1521
Onchocerca volvulus Protein melted homolog 0.0033 0.0031 0.0295
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0224 0.0224
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Brugia malayi Fibronectin type III domain containing protein 0.0046 0.0088 0.0085
Schistosoma mansoni hypothetical protein 0.0033 0.0031 0.0031
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0033 0.0031 0.1706
Brugia malayi hypothetical protein 0.0104 0.0348 0.0345
Loa Loa (eye worm) RGS-3 protein 0.0365 0.1521 0.1518
Schistosoma mansoni hypothetical protein 0.0027 0.0003 0.0003
Echinococcus granulosus cytohesin 1 0.0033 0.0031 0.0037
Echinococcus multilocularis tumor protein p63 0.0408 0.1716 0.2053
Brugia malayi Regulator of G protein signaling domain containing protein 0.0365 0.1521 0.1518
Echinococcus granulosus oxysterol binding protein 1 0.0033 0.0031 0.0037
Echinococcus granulosus Pleckstrin y 0.0033 0.0031 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0365 0.1521 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0085 0.0082
Loa Loa (eye worm) hypothetical protein 0.0046 0.0085 0.0082
Loa Loa (eye worm) cytohesin 3 0.0033 0.0031 0.0028
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0033 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0104 0.0348 0.0345
Onchocerca volvulus 0.0033 0.0031 0.0295
Echinococcus multilocularis rac serine:threonine kinase 0.0043 0.0072 0.0086
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Entamoeba histolytica PH domain containing protein kinase, putative 0.0043 0.0072 0.0475
Entamoeba histolytica protein kinase, putative 0.0043 0.0072 0.0475
Schistosoma mansoni fibrocystin l 0.0046 0.0085 0.0085
Echinococcus multilocularis hypothetical protein 0.0104 0.0348 0.0416
Echinococcus granulosus transcription factor collier 0.0046 0.0085 0.0102
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0365 0.1521 0.1521
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Echinococcus granulosus regulator of G protein signaling 3 0.0365 0.1521 0.1819
Brugia malayi Regulator of G protein signaling domain containing protein 0.0365 0.1521 0.1518
Echinococcus granulosus axis inhibition protein axin 0.0365 0.1521 0.1819
Echinococcus multilocularis semaphorin 5B 0.0104 0.0348 0.0416
Loa Loa (eye worm) hypothetical protein 0.0365 0.1521 0.1518
Echinococcus granulosus plexin a4 0.0281 0.1146 0.1371
Loa Loa (eye worm) hypothetical protein 0.0104 0.0348 0.0345
Echinococcus multilocularis Immunoglobulin 0.0046 0.0088 0.0105
Brugia malayi Protein kinase domain containing protein 0.0043 0.0072 0.0069
Brugia malayi regulator of G-protein signaling egl-10 0.0365 0.1521 0.1518
Echinococcus multilocularis dynamin 1 0.0033 0.0031 0.0037
Entamoeba histolytica hypothetical protein 0.0043 0.0072 0.0475
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0033 0.0031 0.1706
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Loa Loa (eye worm) AUR protein kinase 0.0067 0.018 0.0177
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0224 0.0221
Schistosoma mansoni oxysterol-binding protein 1 0.0033 0.0031 0.0031
Entamoeba histolytica ARF GTPase activating protein, putative 0.0033 0.0031 0.0202
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Loa Loa (eye worm) TK/ALK protein kinase 0.0245 0.0984 0.0981
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0043 0.0072 0.4019
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Schistosoma mansoni hypothetical protein 0.0104 0.0348 0.0348
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Loa Loa (eye worm) hypothetical protein 0.0365 0.1521 0.1518
Echinococcus granulosus pleckstrin y domain containing family A 0.0033 0.0031 0.0037
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0043 0.0072 0.4019
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Echinococcus granulosus regulator of G protein signaling 3 0.0365 0.1521 0.1819
Loa Loa (eye worm) hypothetical protein 0.0046 0.0085 0.0082
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0035 0.0031
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0028
Onchocerca volvulus 0.0033 0.0031 0.0295
Loa Loa (eye worm) hypothetical protein 0.0046 0.0088 0.0085
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0072 0.0279

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 9.1962 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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